ZA9810499B - Granules comprising clavulanate and excipients - Google Patents

Granules comprising clavulanate and excipients

Info

Publication number
ZA9810499B
ZA9810499B ZA9810499A ZA9810499A ZA9810499B ZA 9810499 B ZA9810499 B ZA 9810499B ZA 9810499 A ZA9810499 A ZA 9810499A ZA 9810499 A ZA9810499 A ZA 9810499A ZA 9810499 B ZA9810499 B ZA 9810499B
Authority
ZA
South Africa
Prior art keywords
clavulanate
excipients
granules
Prior art date
Application number
ZA9810499A
Inventor
Jan Willem Groedendaal
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of ZA9810499B publication Critical patent/ZA9810499B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ZA9810499A 1997-11-17 1998-11-17 Granules comprising clavulanate and excipients ZA9810499B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97203576 1997-11-17

Publications (1)

Publication Number Publication Date
ZA9810499B true ZA9810499B (en) 1999-05-24

Family

ID=8228930

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9810499A ZA9810499B (en) 1997-11-17 1998-11-17 Granules comprising clavulanate and excipients

Country Status (13)

Country Link
EP (1) EP0973520A1 (en)
JP (1) JP2001516365A (en)
CN (1) CN1242705A (en)
AU (1) AU1337999A (en)
BR (1) BR9806280A (en)
CA (1) CA2272402A1 (en)
CO (1) CO4980893A1 (en)
JO (1) JO2082B1 (en)
NO (1) NO993467D0 (en)
PL (1) PL334517A1 (en)
TR (1) TR199901584T1 (en)
WO (1) WO1999025343A1 (en)
ZA (1) ZA9810499B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294199B1 (en) 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
US7250176B1 (en) 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
EP1330236A2 (en) 2000-10-12 2003-07-30 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
GB0031267D0 (en) * 2000-12-21 2001-01-31 Smithkline Beecham Plc Novel compositions
AT413983B (en) * 2001-04-12 2006-08-15 Sandoz Ag Pharmaceutical composition useful for reducing rapid degradation of the active ingredient comprises clavulanate, in the form of granulated and hydrophobised particles, and an active ingredient
AT412344B (en) * 2001-04-12 2005-01-25 Sandoz Ag Pharmaceutical composition useful for reducing rapid degradation of the active ingredient comprises clavulanate, in the form of granulated and hydrophobised particles, and an active ingredient
CA2523079C (en) * 2003-05-02 2012-08-14 Globopharm Pharmazeutische Produktions-Und Handelsgesellschaft M.B.H. Solid pharmaceutical preparation containing levothyroxine and/or liothyronine salts
US8293272B2 (en) * 2003-05-02 2012-10-23 Globopharm Pharmazeutische Produktions-Und Handelsgesellschaft M.B.H. Solid pharmaceutical preparation containing levothyroxine and/or liothyronine salts
FI20080346A0 (en) * 2008-05-09 2008-05-09 Atacama Labs Oy Process for making a tablet containing additives
US8951562B2 (en) 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
FI20080353A0 (en) * 2008-05-09 2008-05-09 Atacama Labs Oy Process for preparing a tablet with extra high drug content
FI20080351A0 (en) * 2008-05-09 2008-05-09 Atacama Labs Oy Process for preparing a tablet with low drug content
FI20080355A0 (en) * 2008-05-09 2008-05-09 Atacama Labs Oy Process for making tablets containing metformin
FI20070521L (en) 2006-11-10 2008-05-11 Atacama Labs Oy Grains, tablets and granulation process
FI20080352A0 (en) * 2008-05-09 2008-05-09 Atacama Labs Oy Process for preparing a tablet with high drug content
WO2009135946A1 (en) 2008-05-09 2009-11-12 Atacama Labs Oy Method and apparatus for dry granulation
EP2890366A1 (en) * 2012-08-28 2015-07-08 DSM Sinochem Pharmaceuticals Netherlands B.V. Composition comprising an antibiotic and a beta-lactamase inhibitor, wherein at least one of them is in the form of mini-tablets
JP2014062064A (en) * 2012-09-21 2014-04-10 Ohara Yakuhin Kogyo Kk Method of producing tablets containing valsartan
JP6141472B2 (en) * 2016-03-02 2017-06-07 大原薬品工業株式会社 Method for producing valsartan-containing tablets
AU2018297656B2 (en) 2017-07-05 2021-09-16 Novartis Ag Novel pharmaceutical composition
CN110051637A (en) * 2019-05-21 2019-07-26 葵花药业集团北京药物研究院有限公司 Amoxicillin and clavulanate potassium preparation and preparation method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2251250C3 (en) * 1972-10-19 1981-06-25 Hoechst Ag, 6230 Frankfurt Process for the production of high-dose antibiotic tablets
NZ187013A (en) * 1977-04-27 1985-04-30 Beecham Group Ltd 9-amino-9-deoxy-clavulanic acid derivatives and pharmaceutical compositions
NZ189022A (en) * 1977-12-08 1981-11-19 Beecham Group Ltd Pharmaceutically acceptable particles of clavulanates dispersed in a polymeric binder
EP0281200B1 (en) * 1987-03-02 1994-01-19 Yamanouchi Europe B.V. Pharmaceutical composition, pharmaceutical granulate and process for their preparation
IL109770A0 (en) * 1993-05-29 1994-11-28 Smithkline Beecham Corp Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby

Also Published As

Publication number Publication date
BR9806280A (en) 2000-02-15
AU1337999A (en) 1999-06-07
NO993467L (en) 1999-07-14
WO1999025343A1 (en) 1999-05-27
TR199901584T1 (en) 2000-01-21
EP0973520A1 (en) 2000-01-26
CO4980893A1 (en) 2000-11-27
NO993467D0 (en) 1999-07-14
CA2272402A1 (en) 1999-05-27
CN1242705A (en) 2000-01-26
JO2082B1 (en) 2000-05-21
JP2001516365A (en) 2001-09-25
PL334517A1 (en) 2000-02-28

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