ZA958604B - A pharmaceutical formulation - Google Patents

A pharmaceutical formulation

Info

Publication number: ZA958604B
Authority: ZA; South Africa
Prior art keywords: pharmaceutical formulation; dissolved; formulation; isoleucine; shipment
Prior art date: 1994-10-13

Application number

ZA958604A

Other languages

English (en)

Inventor

Hans Holmegaard Sorensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-13

Filing date

1995-10-12

Publication date

1996-05-14

1995-10-12 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1996-05-14 Publication of ZA958604B publication Critical patent/ZA958604B/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
102000018997 Growth Hormone Human genes 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
239000006172 buffering agent Substances 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
230000006240 deamidation Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
229960000310 isoleucine Drugs 0.000 abstract 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA958604A 1994-10-13 1995-10-12 A pharmaceutical formulation ZA958604B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/322,837 US5631225A (en)	1994-10-13	1994-10-13	Pharmaceutical formulation

Publications (1)

Publication Number	Publication Date
ZA958604B true ZA958604B (en)	1996-05-14

Family

ID=23256650

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA958604A ZA958604B (en)	1994-10-13	1995-10-12	A pharmaceutical formulation

Country Status (11)

Country	Link
US (1)	US5631225A (xx)
EP (1)	EP0785796B1 (xx)
JP (1)	JP4064454B2 (xx)
KR (1)	KR970706839A (xx)
AT (1)	ATE214614T1 (xx)
AU (1)	AU699345B2 (xx)
DE (1)	DE69525955T2 (xx)
ES (1)	ES2173197T3 (xx)
IL (1)	IL115590A (xx)
WO (1)	WO1996011703A1 (xx)
ZA (1)	ZA958604B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6022858A (en) *	1991-12-20	2000-02-08	Novo Nordisk A/S	Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
US6582728B1 (en) *	1992-07-08	2003-06-24	Inhale Therapeutic Systems, Inc.	Spray drying of macromolecules to produce inhaleable dry powders
US6673335B1 (en)	1992-07-08	2004-01-06	Nektar Therapeutics	Compositions and methods for the pulmonary delivery of aerosolized medicaments
WO1994007514A1 (en) *	1992-09-29	1994-04-14	Inhale Therapeutic Systems	Pulmonary delivery of active fragments of parathyroid hormone
US20030113273A1 (en) *	1996-06-17	2003-06-19	Patton John S.	Methods and compositions for pulmonary delivery of insulin
KR100384353B1 (ko) *	1994-05-18	2003-10-04	네크타르 테라퓨틱스	인터페론의건조분말제형을제조하기위한방법및조성물
US6290991B1 (en) *	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
US20030035778A1 (en) *	1997-07-14	2003-02-20	Robert Platz	Methods and compositions for the dry powder formulation of interferon
US6565885B1 (en)	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6309623B1 (en) *	1997-09-29	2001-10-30	Inhale Therapeutic Systems, Inc.	Stabilized preparations for use in metered dose inhalers
PL357471A1 (en) *	1999-11-09	2004-07-26	Rappold-Hoerbrand Gudrun	Methods of treating short stature disorders related to the short stature homeobox-containing (shox) gene
CA2382133C (en)	2000-05-10	2010-11-23	Alliance Pharmaceutical Corporation	Phospholipid-based powders for drug delivery
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en)	2000-05-10	2013-03-26	Novartis Ag	Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
MXPA03001092A (es) *	2000-08-07	2003-09-25	Nektar Therapeutics Al Corp	Polvos de proteina de haz de 4 helices secados por rocio, inhalables, que tienen agregacion minimizada.
US7368102B2 (en)	2001-12-19	2008-05-06	Nektar Therapeutics	Pulmonary delivery of aminoglycosides
WO2009002521A2 (en) *	2007-06-25	2008-12-31	Amgen Inc.	Compositions of specific binding agents to hepatocyte growth factor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4056520A (en) *	1972-03-31	1977-11-01	Research Corporation	Clinically active bovine growth hormone fraction
US4563352A (en) *	1982-10-04	1986-01-07	The Salk Institute For Biological Studies	Human pancreatic GRF
JPS5967228A (ja) *	1982-10-07	1984-04-16	Green Cross Corp:The	寒冷不溶性グロブリンの凍結乾燥方法
US4917685A (en) *	1986-05-16	1990-04-17	International Minerals & Chem. Corp.	Delivery device for the administration of stabilized growth promoting hormones
EP0303746B2 (en) *	1987-08-21	1998-12-02	Mallinckrodt Group Inc.	Stabilization of growth promoting hormones
US5096885A (en) *	1988-04-15	1992-03-17	Genentech, Inc.	Human growth hormone formulation
EP0374120A3 (en) *	1988-12-13	1991-07-31	Monsanto Company	Comosition for controlled release of polypeptides
US5137872A (en) *	1989-09-18	1992-08-11	Pitman-Moore, Inc.	Growth hormone-releasing factor analogs
DK204791D0 (da) *	1991-12-20	1991-12-20	Novo Nordisk As	Hidtil ukendt farmaceutisk praeparat
ES2291264T3 (es) *	1991-12-20	2008-03-01	Novo Nordisk A/S	Formulacion farmaceutica estabilizada comprendiendo una hormona de crecimiento e histidina.
SE9201073D0 (sv) *	1992-04-03	1992-04-03	Kabi Pharmacia Ab	Protein formulation
DE69329651T3 (de) *	1992-07-31	2008-10-30	Genentech, Inc., South San Francisco	Wässrige arzneizusammensetzung, welche das menschliche wachstumshormon enthält

1994
- 1994-10-13 US US08/322,837 patent/US5631225A/en not_active Expired - Lifetime
1995
- 1995-10-12 ZA ZA958604A patent/ZA958604B/xx unknown
- 1995-10-12 IL IL11559095A patent/IL115590A/xx not_active IP Right Cessation
- 1995-10-13 JP JP51286296A patent/JP4064454B2/ja not_active Expired - Fee Related
- 1995-10-13 ES ES95933346T patent/ES2173197T3/es not_active Expired - Lifetime
- 1995-10-13 AT AT95933346T patent/ATE214614T1/de not_active IP Right Cessation
- 1995-10-13 EP EP95933346A patent/EP0785796B1/en not_active Expired - Lifetime
- 1995-10-13 WO PCT/DK1995/000409 patent/WO1996011703A1/en active IP Right Grant
- 1995-10-13 KR KR1019970702430A patent/KR970706839A/ko active IP Right Grant
- 1995-10-13 AU AU36053/95A patent/AU699345B2/en not_active Ceased
- 1995-10-13 DE DE69525955T patent/DE69525955T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL115590A (en)	2000-02-29
EP0785796A1 (en)	1997-07-30
KR970706839A (ko)	1997-12-01
AU3605395A (en)	1996-05-06
ATE214614T1 (de)	2002-04-15
AU699345B2 (en)	1998-12-03
IL115590A0 (en)	1996-01-19
DE69525955D1 (de)	2002-04-25
JP4064454B2 (ja)	2008-03-19
DE69525955T2 (de)	2002-11-07
US5631225A (en)	1997-05-20
JPH10507182A (ja)	1998-07-14
EP0785796B1 (en)	2002-03-20
ES2173197T3 (es)	2002-10-16
WO1996011703A1 (en)	1996-04-25

Publication	Publication Date	Title
IL115590A0 (en)	1996-01-19	Pharmaceutical formulation comprising a growth hormone and isoleucine
HU9401831D0 (en)	1994-09-28	Stabilized pharmaceutical formulations comprising growth hormone and asparagine
IL115591A0 (en)	1996-01-19	Pharmaceutical formulation comprising a growth hormone and valine
CA2125855A1 (en)	1993-07-08	A stabilized pharmaceutical formulation comprising growth hormone and histidine
AU610636B2 (en)	1991-05-23	Stabilised human protein preparations
BG106046A (en)	2002-05-31	Pharmaceutical compositions of ertythropoietin
IL115592A0 (en)	1996-01-19	Pharmaceutical formulation comprising a growth hormone and leucine
MX9800309A (es)	1998-07-31	Formulacion farmaceutica estabilizada que comprende una hormona del crecimiento y un peptido que comprende al menos un residuo de aminoacido basico y al menos un residuo de aminoacido acido.
MX9800358A (es)	1998-07-31	Formulacion farmaceutica estabilizada que comprende una hormona del crecimiento pretratada con zinc y opcionalmente lisina o iones calcio.
AU1879097A (en)	1997-09-16	Fragments of cr1 and their use