ZA922535B - Amidinophenylalanine derivatives,process for their preparation,their use and compositions containing them - Google Patents

Amidinophenylalanine derivatives,process for their preparation,their use and compositions containing them

Info

Publication number: ZA922535B
Authority: ZA; South Africa
Prior art keywords: preparation; compositions containing; amidinophenylalanine derivatives; amidinophenylalanine; derivatives
Prior art date: 1991-04-09

Application number

ZA922535A

Other languages

English (en)

Inventor

Werner Stueber

Stueber Werner

Gerhard Dickeite

Dickeite Gerhard

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-09

Filing date

1992-04-08

Publication date

1992-11-25

1992-04-08 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1992-11-25 Publication of ZA922535B publication Critical patent/ZA922535B/xx

Links

MVTHUEOHHHQQKY-QMMMGPOBSA-N (2s)-2-(diaminomethylideneamino)-3-phenylpropanoic acid Chemical class NC(N)=N[C@H](C(O)=O)CC1=CC=CC=C1 MVTHUEOHHHQQKY-QMMMGPOBSA-N 0.000 title abstract 2
239000000203 mixture Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Plant Substances (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Pyrrole Compounds (AREA)

ZA922535A 1991-04-09 1992-04-08 Amidinophenylalanine derivatives,process for their preparation,their use and compositions containing them ZA922535B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4111394A DE4111394A1 (de)	1991-04-09	1991-04-09	Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel

Publications (1)

Publication Number	Publication Date
ZA922535B true ZA922535B (en)	1992-11-25

Family

ID=6429103

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA922535A ZA922535B (en)	1991-04-09	1992-04-08	Amidinophenylalanine derivatives,process for their preparation,their use and compositions containing them

Country Status (28)

Country	Link
US (1)	US5274098A (zh)
EP (1)	EP0508220B1 (zh)
JP (1)	JPH0597793A (zh)
KR (1)	KR920019738A (zh)
CN (1)	CN1067431A (zh)
AT (1)	ATE125549T1 (zh)
AU (1)	AU650526B2 (zh)
BG (1)	BG60683B1 (zh)
BR (1)	BR9201253A (zh)
CA (1)	CA2065585A1 (zh)
CS (1)	CS106492A3 (zh)
DE (2)	DE4111394A1 (zh)
DK (1)	DK0508220T3 (zh)
ES (1)	ES2076595T3 (zh)
FI (1)	FI921525A (zh)
GR (1)	GR3017107T3 (zh)
HU (1)	HUT65359A (zh)
IE (1)	IE67347B1 (zh)
IL (1)	IL101529A (zh)
MA (1)	MA22495A1 (zh)
MX (1)	MX9201642A (zh)
NO (1)	NO921382L (zh)
NZ (1)	NZ242246A (zh)
PL (1)	PL294148A1 (zh)
RO (1)	RO109197B1 (zh)
TW (1)	TW214542B (zh)
UY (1)	UY23395A1 (zh)
ZA (1)	ZA922535B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4115468A1 (de) *	1991-05-11	1992-11-12	Behringwerke Ag	Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE4242655A1 (de) *	1992-12-17	1994-06-23	Behringwerke Ag	Verwendung von Thrombin-Inhibitoren zur Inhibition okularer Fibrinbildung
DE4342154A1 (de) *	1993-12-10	1995-06-14	Behringwerke Ag	Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
AU3107795A (en) *	1994-08-09	1996-03-07	Pentapharm Ag	Inhibitors of the benzamidine type
US5525617A (en) *	1994-08-24	1996-06-11	Merck & Co., Inc.	Fibrinogen receptor antagonists
DE19517198C1 (de) *	1995-05-11	1996-10-10	Samson Ag	Verfahren zur Führung der Hubstellung eines Stellgliedes
US5766932A (en) *	1995-12-20	1998-06-16	Hoechst Marion Roussel, Inc.	Process for preparing N-acetyl(L)-4-cyanophenylalanine from a mixture of the corresponding D,L ethyl esters using subtilisin
US5840733A (en) *	1996-07-01	1998-11-24	Redcell, Canada, Inc.	Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
KR19990074598A (ko) *	1998-03-12	1999-10-05	성재갑	고체상 반응을 이용한 벤즈아미딘 유도체의 신규한 제조방법
SK287781B6 (sk)	2000-08-18	2011-09-05	Ajinomoto Co., Inc.	Fenylalanínové deriváty, farmaceutický prípravok s ich obsahom a ich použitie
SI21137A (sl) *	2002-01-24	2003-08-31	LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d.	Derivati azafenilalanina
DE10330900B4 (de) *	2003-07-01	2006-09-14	Leibniz-Institut Für Polymerforschung Dresden E.V.	Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt
CN1917881B (zh) *	2003-12-22	2014-11-26	味之素株式会社	新型苯基丙氨酸衍生物
AU2005314252B2 (en)	2004-12-06	2012-09-27	Siga Technologies, Inc.	Compounds and methods for treating hemorrhagic fever viruses
US7994221B2 (en)	2004-12-06	2011-08-09	Siga Technologies, Inc.	Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US8410149B2 (en)	2004-12-06	2013-04-02	Siga Technologies Inc.	Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
CN101034257B (zh) *	2007-04-06	2010-09-08	上海复旦天臣新技术有限公司	用于全息记录的感光薄膜及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4028380A (en) *	1974-06-01	1977-06-07	Akzona Incorporated	Hydrazino-imidazole derivatives
DD155954B1 (de) *	1981-02-03	1988-11-09	Wagner Guenter	Verfahren zur herstellung von n tief alpha arly-bzw. n tief alpha heteroarylsulfonylaminoacylierten amidinophenylalaninamiden
DD235866B1 (de) *	1985-03-29	1988-12-28	Univ Leipzig	Verfahren zur herstellung von n alpha (2-naphthyl)-sulfonylaminoacylierten amidinophenylalanisamiden
PT84170B (pt) *	1986-01-24	1989-03-30	Sanofi Sa	Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
PT84171B (pt) *	1986-01-24	1989-03-30	Sanofi Sa	Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem

1991
- 1991-04-09 DE DE4111394A patent/DE4111394A1/de not_active Withdrawn
1992
- 1992-03-25 ES ES92105138T patent/ES2076595T3/es not_active Expired - Lifetime
- 1992-03-25 EP EP92105138A patent/EP0508220B1/de not_active Expired - Lifetime
- 1992-03-25 DK DK92105138.9T patent/DK0508220T3/da active
- 1992-03-25 DE DE59203006T patent/DE59203006D1/de not_active Expired - Fee Related
- 1992-03-25 AT AT92105138T patent/ATE125549T1/de not_active IP Right Cessation
- 1992-04-02 BG BG96171A patent/BG60683B1/bg unknown
- 1992-04-06 NZ NZ242246A patent/NZ242246A/en unknown
- 1992-04-06 UY UY23395A patent/UY23395A1/es unknown
- 1992-04-07 TW TW081102613A patent/TW214542B/zh active
- 1992-04-07 FI FI921525A patent/FI921525A/fi not_active Application Discontinuation
- 1992-04-07 MA MA22776A patent/MA22495A1/fr unknown
- 1992-04-07 RO RO92-200477A patent/RO109197B1/ro unknown
- 1992-04-07 US US07/864,547 patent/US5274098A/en not_active Expired - Fee Related
- 1992-04-07 CN CN92102446A patent/CN1067431A/zh active Pending
- 1992-04-08 KR KR1019920005804A patent/KR920019738A/ko not_active Application Discontinuation
- 1992-04-08 HU HU9201189A patent/HUT65359A/hu unknown
- 1992-04-08 NO NO92921382A patent/NO921382L/no unknown
- 1992-04-08 ZA ZA922535A patent/ZA922535B/xx unknown
- 1992-04-08 IL IL10152992A patent/IL101529A/en not_active IP Right Cessation
- 1992-04-08 CS CS921064A patent/CS106492A3/cs unknown
- 1992-04-08 CA CA002065585A patent/CA2065585A1/en not_active Abandoned
- 1992-04-08 PL PL29414892A patent/PL294148A1/xx unknown
- 1992-04-08 BR BR929201253A patent/BR9201253A/pt not_active Application Discontinuation
- 1992-04-08 IE IE921123A patent/IE67347B1/en not_active IP Right Cessation
- 1992-04-08 JP JP4085807A patent/JPH0597793A/ja active Pending
- 1992-04-08 AU AU14703/92A patent/AU650526B2/en not_active Ceased
- 1992-04-09 MX MX9201642A patent/MX9201642A/es not_active IP Right Cessation
1995
- 1995-08-11 GR GR950402218T patent/GR3017107T3/el unknown

Also Published As

Publication number	Publication date
GR3017107T3 (en)	1995-11-30
CS106492A3 (en)	1992-10-14
IE921123A1 (en)	1992-10-21
NO921382D0 (no)	1992-04-08
AU1470392A (en)	1992-10-15
ATE125549T1 (de)	1995-08-15
MA22495A1 (fr)	1992-12-31
EP0508220B1 (de)	1995-07-26
AU650526B2 (en)	1994-06-23
MX9201642A (es)	1992-10-01
ES2076595T3 (es)	1995-11-01
CN1067431A (zh)	1992-12-30
PL294148A1 (zh)	1993-02-08
BG96171A (bg)	1993-12-24
US5274098A (en)	1993-12-28
BR9201253A (pt)	1992-12-01
KR920019738A (ko)	1992-11-19
FI921525A (fi)	1992-10-10
RO109197B1 (ro)	1994-12-30
NZ242246A (en)	1993-12-23
HU9201189D0 (en)	1992-07-28
DE4111394A1 (de)	1992-10-15
TW214542B (zh)	1993-10-11
EP0508220A1 (de)	1992-10-14
HUT65359A (en)	1994-05-02
DE59203006D1 (de)	1995-08-31
BG60683B1 (bg)	1995-12-29
FI921525A0 (fi)	1992-04-07
IL101529A0 (en)	1992-12-30
IE67347B1 (en)	1996-03-20
NO921382L (no)	1992-10-12
IL101529A (en)	1996-05-14
UY23395A1 (es)	1992-04-21
JPH0597793A (ja)	1993-04-20
CA2065585A1 (en)	1992-10-10
DK0508220T3 (da)	1995-11-27

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DE3366141D1 (en)	1986-10-16	1-phenylisoquinoline derivatives, process for their preparation, pharmaceutical compositions containing these compounds and their use
HK1006717A1 (en)	1999-03-12	Derivatives of amidinophenylalanine procedure for their preparation their utilisation and anticoagulant compositions comprising them
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ZA914046B (en)	1992-03-25	New berbane derivatives,pharmaceutical compositions containing these compounds and process for the preparation of same
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