ZA84670B - Thiorphan analogs as enkephalinase and angiotensin converting enzyme inhibitors - Google Patents

Thiorphan analogs as enkephalinase and angiotensin converting enzyme inhibitors

Info

Publication number
ZA84670B
ZA84670B ZA84670A ZA84670A ZA84670B ZA 84670 B ZA84670 B ZA 84670B ZA 84670 A ZA84670 A ZA 84670A ZA 84670 A ZA84670 A ZA 84670A ZA 84670 B ZA84670 B ZA 84670B
Authority
ZA
South Africa
Prior art keywords
thiorphan
enkephalinase
analogs
converting enzyme
enzyme inhibitors
Prior art date
Application number
ZA84670A
Inventor
David Taub
Jan Ten Broeke
Morris Zimmerman
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA84670B publication Critical patent/ZA84670B/en

Links

ZA84670A 1983-01-31 1984-01-30 Thiorphan analogs as enkephalinase and angiotensin converting enzyme inhibitors ZA84670B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46272983A 1983-01-31 1983-01-31

Publications (1)

Publication Number Publication Date
ZA84670B true ZA84670B (en) 1985-09-25

Family

ID=23837551

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA84670A ZA84670B (en) 1983-01-31 1984-01-30 Thiorphan analogs as enkephalinase and angiotensin converting enzyme inhibitors

Country Status (1)

Country Link
ZA (1) ZA84670B (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012003A1 (en) * 1989-04-10 1990-10-18 Schering Corporation Mercapto-acylamino acids
US5179125A (en) * 1987-12-03 1993-01-12 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US5356925A (en) * 1990-08-16 1994-10-18 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
US5414017A (en) * 1990-03-22 1995-05-09 E. R. Squibb & Sons, Inc. Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
EP2340828A1 (en) 2005-11-09 2011-07-06 Novartis AG Pharmaceutical combinations of an angiotensin receptor antagonist and an nep inhibitor
WO2017033128A1 (en) 2015-08-25 2017-03-02 Novartis Ag Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
WO2017072636A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical synergistic combination
EP3943084A1 (en) 2012-08-24 2022-01-26 Novartis AG Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179125A (en) * 1987-12-03 1993-01-12 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
WO1990012003A1 (en) * 1989-04-10 1990-10-18 Schering Corporation Mercapto-acylamino acids
US5219886A (en) * 1989-04-10 1993-06-15 Schering Corporation Mercapto-acylamino acids
US5414013A (en) * 1990-03-22 1995-05-09 E. R. Squibb & Sons, Inc. Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
US5414017A (en) * 1990-03-22 1995-05-09 E. R. Squibb & Sons, Inc. Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
US5356925A (en) * 1990-08-16 1994-10-18 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
EP2340828A1 (en) 2005-11-09 2011-07-06 Novartis AG Pharmaceutical combinations of an angiotensin receptor antagonist and an nep inhibitor
US11096918B2 (en) 2005-11-09 2021-08-24 Novartis Pharmaceuticals Corporation Amorphous solid form of compounds containing S—N-valeryl-N-{[2′-(1H-tetrazole-5-yl)-biphenyl-4-yl]-methyl}-valine and (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester moieties and sodium cations
US11642329B2 (en) 2005-11-09 2023-05-09 Novartis Pharmaceuticals Corporation Amorphous solid form of compounds containing S—N-valeryl-N- {[2′-( 1 H-tetrazole-5-yl)-biphenyl-4-yl]-methyl}-valine and (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester moieties and sodium cations
EP3943084A1 (en) 2012-08-24 2022-01-26 Novartis AG Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling
WO2017033128A1 (en) 2015-08-25 2017-03-02 Novartis Ag Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
WO2017072636A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical synergistic combination

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