YU46559B - Postupak za dobivanje novih derivata difenilpropilamina - Google Patents

Postupak za dobivanje novih derivata difenilpropilamina

Info

Publication number
YU46559B
YU46559B YU129987A YU129987A YU46559B YU 46559 B YU46559 B YU 46559B YU 129987 A YU129987 A YU 129987A YU 129987 A YU129987 A YU 129987A YU 46559 B YU46559 B YU 46559B
Authority
YU
Yugoslavia
Prior art keywords
denotes
denotes hydrogen
hydrogen
preparation
benzyloxy
Prior art date
Application number
YU129987A
Other languages
English (en)
Other versions
YU129987A (en
Inventor
D. Korbonits
P. Kiss
L. Szekeres
G. Papp
G. Kovacs
Cusutor A. Santane
S. Virag
E. Udvari
I. Bata
Kellner K. Marmarosi
L. Tardos
P. Kormoszy
V. Gergely
Z. Vargai
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority to SI8711299A priority Critical patent/SI8711299A8/sl
Publication of YU129987A publication Critical patent/YU129987A/xx
Priority to HR930508A priority patent/HRP930508A2/hr
Publication of YU46559B publication Critical patent/YU46559B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

POSTUPAK ZA DOBIVANJE NOVIH DERIVATA DIFENILPROPILAMINA, opšte formule I: gde R1 je vodonik ili metil grupa, R2 je vodonik, metil ili n-decil grupa, Z je fenil grupa supstituisana sa R3, R4 i R5, gde R3 je vodonik, fluor, hlor ili brom ili nitro, C1-12alkil, C1-4alkoksi, fenoksi ili benziloksi grupa, R4 i R5 predstavljaju vodonik, hlor ili hidroksi, alkoksi, benziloksi grupu, ili R4 i R5 zajedno grade metilendioksi grupu ili Z može biti 4-metoksinafdtil ili 4-etoksinaftil grupa, i R6 je vodonik ili fluor, uz ograničenje da svaki od R1, R2, R3, R4, R5 i R6, be nigz ustivremeno biti vodonik kada R2 je metil, kao i njihovih fiziološki prihvatljivih adicionih soli, naznačen time, što se defenilpropilaminski derivat opšte formule II gde je A je vodonik, i R6 je kao što je definisano napred podvrgava reduktivnoj kondenzacionoj reakciji sa ketonom opšte formule II gde je R2 i Z su kao što je definisano napred, u jednom stupnju ili, ako se želi, u dva stupnja, u organskom rastvaraču ili sredini bez rastvarača na temperaturi od 20-90В°C pod pritiskom od 100 do 1 000 000 Pa i ako se želi jedinjenje opšte formule I, gde je R1 je vodonik i R2, R3, R4, R5, R6 i Z su kao što je definisano napred se prevodi u tercijerni amin metilovanjem na azotu i ako se želi tako dobiveno jedinjenje opšte formule I se prevodi u adicionu so kiseline sa neorganskom ili organskom kiselinom.
YU129987A 1986-07-11 1987-07-10 Postupak za dobivanje novih derivata difenilpropilamina YU46559B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8711299A SI8711299A8 (en) 1986-07-11 1987-07-10 Process for preparing new diphenylpropylamine derivatives
HR930508A HRP930508A2 (en) 1986-07-11 1993-03-24 Difenilpropilamina process for the preparation of the novel enylpropylamine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862873A HU200591B (en) 1986-07-11 1986-07-11 Process for producing new diphenyl propylamine derivatives and pharmaceutical compositions comprising such compounds

Publications (2)

Publication Number Publication Date
YU129987A YU129987A (en) 1988-06-30
YU46559B true YU46559B (sh) 1993-11-16

Family

ID=55982790

Family Applications (1)

Application Number Title Priority Date Filing Date
YU129987A YU46559B (sh) 1986-07-11 1987-07-10 Postupak za dobivanje novih derivata difenilpropilamina

Country Status (28)

Country Link
US (1) US4988730A (sh)
EP (1) EP0253327B1 (sh)
JP (1) JP2637737B2 (sh)
KR (1) KR910000864B1 (sh)
CN (1) CN1019571B (sh)
AT (1) ATE75722T1 (sh)
AU (1) AU599117B2 (sh)
CA (1) CA1335104C (sh)
CS (1) CS271343B2 (sh)
DD (1) DD263980A5 (sh)
DE (1) DE3778770D1 (sh)
DK (1) DK360187A (sh)
ES (1) ES2032778T3 (sh)
FI (1) FI95128C (sh)
GR (1) GR3004518T3 (sh)
HR (1) HRP930508A2 (sh)
HU (1) HU200591B (sh)
IE (1) IE60028B1 (sh)
IL (1) IL83044A (sh)
NO (1) NO167658C (sh)
NZ (1) NZ221036A (sh)
PH (1) PH24514A (sh)
PL (1) PL150887B1 (sh)
PT (1) PT85304B (sh)
SI (1) SI8711299A8 (sh)
SU (2) SU1597096A3 (sh)
YU (1) YU46559B (sh)
ZA (1) ZA874812B (sh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1205124B (it) * 1987-06-05 1989-03-15 Simens Soteta Italiana Medicin Composto attivo nella terapia carciovascolare
GB8823203D0 (en) * 1988-10-04 1988-11-09 Pfizer Ltd Therapeutic agents
JPH04329415A (ja) * 1991-04-30 1992-11-18 Fujitsu Ltd カード型入出力インタフェース装置及びシステム
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
DK1281702T3 (da) * 1991-08-23 2006-04-18 Nps Pharma Inc Calciumreceptoraktive molekyler
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5198548A (en) * 1992-01-30 1993-03-30 Warner-Lambert Company Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
ATE267009T1 (de) * 1993-02-23 2004-06-15 Brigham & Womens Hospital Calciumrezeptoraktive moleküle
US5492933A (en) * 1993-10-08 1996-02-20 Sepracor, Inc. Methods and compositions for treating urinary incontinence and other disorders using optically pure R-terodiline and hydroxylated derivatives thereof
PL183499B1 (pl) 1994-10-21 2002-06-28 Nps Pharma Inc Związki do modulowania receptorów wapniowych i kompozycje farmaceutyczne
EP0907631B1 (en) * 1996-05-01 2003-06-18 Nps Pharmaceuticals, Inc. Inorganic ion receptor-active compounds
SE9701144D0 (sv) * 1997-03-27 1997-03-27 Pharmacia & Upjohn Ab Novel compounds, their use and preparation
US6124507A (en) 1997-12-10 2000-09-26 Union Carbide Chemicals & Plastics Technology Corporation Electron donors
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1171930B (de) * 1961-08-10 1964-06-11 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von koronardilatent wirksamen substituierten Propylaminderivaten
CH462189A (de) * 1961-08-10 1968-09-15 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von substituierten Propylaminderivaten
GB1032650A (en) * 1962-05-24 1966-06-15 Chinoin Gyogyszer Es Vegyeszet Improvements in or relating to diphenyl-propylamine derivatives
DD122967A1 (de) * 1975-07-10 1976-11-12 Lothar Luecke Hylamin-derivate

Also Published As

Publication number Publication date
NO167658C (no) 1991-11-27
CS511987A2 (en) 1989-08-14
DK360187D0 (da) 1987-07-10
IL83044A (en) 1991-09-16
PT85304B (pt) 1990-03-30
PH24514A (en) 1990-07-18
PL266759A1 (en) 1988-09-01
ZA874812B (en) 1988-10-26
EP0253327A2 (de) 1988-01-20
AU7552687A (en) 1988-01-14
HUT46651A (en) 1988-11-28
SI8711299A8 (en) 1996-08-31
SU1597096A3 (ru) 1990-09-30
CA1335104C (en) 1995-04-04
GR3004518T3 (sh) 1993-04-28
IE60028B1 (en) 1994-05-18
NO872880L (no) 1988-01-12
JPS6372657A (ja) 1988-04-02
PL150887B1 (en) 1990-07-31
NO872880D0 (no) 1987-07-10
EP0253327B1 (de) 1992-05-06
FI95128B (fi) 1995-09-15
YU129987A (en) 1988-06-30
ES2032778T3 (es) 1993-03-01
EP0253327A3 (en) 1988-11-30
ATE75722T1 (de) 1992-05-15
DD263980A5 (de) 1989-01-18
CN87104753A (zh) 1988-06-15
JP2637737B2 (ja) 1997-08-06
SU1588740A1 (ru) 1990-08-30
KR880001573A (ko) 1988-04-25
KR910000864B1 (ko) 1991-02-11
CN1019571B (zh) 1992-12-23
DE3778770D1 (de) 1992-06-11
US4988730A (en) 1991-01-29
NZ221036A (en) 1990-05-28
FI95128C (fi) 1995-12-27
FI873069A0 (fi) 1987-07-10
HRP930508A2 (en) 1995-02-28
HU200591B (en) 1990-07-28
NO167658B (no) 1991-08-19
AU599117B2 (en) 1990-07-12
CS271343B2 (en) 1990-09-12
IL83044A0 (en) 1987-12-31
FI873069A (fi) 1988-01-12
DK360187A (da) 1988-01-12
PT85304A (en) 1987-08-01
IE871866L (en) 1988-01-11

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