YU39503A - Derivati pirimidina - Google Patents
Derivati pirimidinaInfo
- Publication number
- YU39503A YU39503A YU39503A YUP39503A YU39503A YU 39503 A YU39503 A YU 39503A YU 39503 A YU39503 A YU 39503A YU P39503 A YUP39503 A YU P39503A YU 39503 A YU39503 A YU 39503A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- lower alkyl
- trifluoromethyl
- receptor
- halogen
- hydrogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ovaj izum se odnosi na jedinjenja opste formule u kojoj R1 je nizi alkil, nizi alkoksi, piridinil, pirimidinil, fenil, S-nizi alkil, -S(O)2-nizi alkil, -N(R)-(CH2)n-N(R)2 -O-(CH2)n-N(R)2, -N(R)2, ili ciklicni tercijarni amin iz grupe koji moze da sadrzi dodatni heteroatom izabran od N, O ili S, i u kome ova grupa moze biti povezana sa prstenom pirimidina preko veze -O(CH2)n-; R2 je vodonik, nizi alkil, nizi alkoksi, halogen ili trifluorometil; R3/R3 je, nezavisno od drugih, vodonik ili nizi alkil; R4 je nezavisno od drugih halogen, trifluorometil ili nizi alkoksi; R5 je vodonik ili nizi alkil; R je, nezavisno od drugih, vodonik ili nizi alkil; X je -C(O)N(R)- ili -N(R)C(O)-; Y je -O-, -S-, -SO2-, ili -N(R)-; n je 1, 2 3 ili 4; i m je 0, 1 ili 2; i na njihove farmaceutski prihvatljive adicione soli kiselina. Ova jedinjenja imaju dobar afinitet prema NK1 receptoru i stoga su podesna za lecenje vrsta bolesti povezanih sa ovim receptorom.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00125529 | 2000-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU39503A true YU39503A (sh) | 2006-05-25 |
Family
ID=8170446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU39503A YU39503A (sh) | 2000-11-22 | 2000-11-13 | Derivati pirimidina |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6787539B2 (sh) |
| EP (1) | EP1339698A2 (sh) |
| JP (1) | JP3993100B2 (sh) |
| KR (1) | KR100571337B1 (sh) |
| CN (1) | CN1309710C (sh) |
| AR (1) | AR031486A1 (sh) |
| AU (2) | AU2792102A (sh) |
| BG (1) | BG107840A (sh) |
| BR (1) | BR0115480A (sh) |
| CA (1) | CA2429570A1 (sh) |
| CZ (1) | CZ20031666A3 (sh) |
| EC (1) | ECSP034619A (sh) |
| GT (1) | GT200100232A (sh) |
| HK (1) | HK1078079A1 (sh) |
| HR (1) | HRP20030362A2 (sh) |
| HU (1) | HUP0303045A3 (sh) |
| IL (2) | IL155705A0 (sh) |
| JO (1) | JO2307B1 (sh) |
| MA (1) | MA26967A1 (sh) |
| MX (1) | MXPA03004453A (sh) |
| NO (1) | NO324865B1 (sh) |
| NZ (1) | NZ525555A (sh) |
| PA (1) | PA8533501A1 (sh) |
| PE (1) | PE20020760A1 (sh) |
| PL (1) | PL366394A1 (sh) |
| RU (1) | RU2284997C2 (sh) |
| SK (1) | SK7612003A3 (sh) |
| UY (1) | UY27034A1 (sh) |
| WO (1) | WO2002042280A2 (sh) |
| YU (1) | YU39503A (sh) |
| ZA (1) | ZA200303517B (sh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20022413A3 (cs) * | 2000-01-31 | 2003-08-13 | Pfizer Products Inc. | Pyrimidinkarboxamidy užitečné jako inhibitory isozymů PDE4 |
| US8455489B2 (en) * | 2003-11-10 | 2013-06-04 | Exelixis, Inc. | Substituted pyrimidine compositions and methods of use |
| JP4501015B2 (ja) | 2004-03-17 | 2010-07-14 | 味の素株式会社 | アミノピリミジン化合物の製造方法 |
| JP4613501B2 (ja) | 2004-03-17 | 2011-01-19 | 味の素株式会社 | ５−保護アミノピリミジン化合物の製造方法 |
| US7280224B2 (en) * | 2004-04-22 | 2007-10-09 | Zygo Corporation | Interferometry systems and methods of using interferometry systems |
| US7482350B2 (en) | 2004-05-08 | 2009-01-27 | Neurogen Corporation | 4,5-disubstituted-2-aryl pyrimidines |
| WO2006089674A2 (en) | 2005-02-25 | 2006-08-31 | F.Hoffmann-La Roche Ag | Tablets with improved drug substance dispersibility |
| DE102005027150A1 (de) * | 2005-03-12 | 2006-09-28 | Bayer Healthcare Ag | Pyrimidincarbonsäure-Derivate und ihre Verwendung |
| KR20090112722A (ko) | 2007-01-24 | 2009-10-28 | 글락소 그룹 리미티드 | 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물 |
| KR101032186B1 (ko) * | 2008-12-31 | 2011-05-02 | 엘에스산전 주식회사 | 정격 미세 조정이 가능한 과전류 계전기 |
| EP2493863B1 (en) * | 2009-10-30 | 2015-02-25 | Janssen Pharmaceutica NV | Phenoxy-substituted pyrimidines as opioid receptor modulators |
| CA2779107C (en) * | 2009-10-30 | 2017-05-30 | Steven J. Coats | Pyrimidine compounds as delta opioid receptor modulators |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57131771A (en) * | 1981-02-10 | 1982-08-14 | Mitsubishi Yuka Yakuhin Kk | Novel pyrimidine derivative |
| FR2536071B1 (fr) * | 1982-11-12 | 1986-07-11 | Sanofi Sa | Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant |
| EP0799617A3 (en) | 1986-02-24 | 1997-11-12 | Mitsui Petrochemical Industries, Ltd. | Therapeutic agent for neurological diseases |
| IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| ATE207917T1 (de) | 1993-12-29 | 2001-11-15 | Merck Sharp & Dohme | Substituierte morpholinderivate und ihre verwendung als arzneimittel |
| IL112778A0 (en) | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
| US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| CZ20022413A3 (cs) * | 2000-01-31 | 2003-08-13 | Pfizer Products Inc. | Pyrimidinkarboxamidy užitečné jako inhibitory isozymů PDE4 |
-
2000
- 2000-11-13 YU YU39503A patent/YU39503A/sh unknown
-
2001
- 2001-10-15 US US09/977,586 patent/US6787539B2/en not_active Expired - Fee Related
- 2001-11-13 MX MXPA03004453A patent/MXPA03004453A/es active IP Right Grant
- 2001-11-13 HU HU0303045A patent/HUP0303045A3/hu unknown
- 2001-11-13 JP JP2002544415A patent/JP3993100B2/ja not_active Expired - Fee Related
- 2001-11-13 AU AU2792102A patent/AU2792102A/xx active Pending
- 2001-11-13 PL PL01366394A patent/PL366394A1/xx not_active Application Discontinuation
- 2001-11-13 NZ NZ525555A patent/NZ525555A/en unknown
- 2001-11-13 EP EP01989463A patent/EP1339698A2/en not_active Withdrawn
- 2001-11-13 AU AU2002227921A patent/AU2002227921B2/en not_active Ceased
- 2001-11-13 BR BR0115480-0A patent/BR0115480A/pt not_active Application Discontinuation
- 2001-11-13 IL IL15570501A patent/IL155705A0/xx active IP Right Grant
- 2001-11-13 WO PCT/EP2001/013084 patent/WO2002042280A2/en active IP Right Grant
- 2001-11-13 RU RU2003117481/04A patent/RU2284997C2/ru not_active IP Right Cessation
- 2001-11-13 CZ CZ20031666A patent/CZ20031666A3/cs unknown
- 2001-11-13 SK SK761-2003A patent/SK7612003A3/sk unknown
- 2001-11-13 CN CNB018191169A patent/CN1309710C/zh not_active Expired - Fee Related
- 2001-11-13 CA CA002429570A patent/CA2429570A1/en not_active Abandoned
- 2001-11-13 KR KR1020037006777A patent/KR100571337B1/ko not_active IP Right Cessation
- 2001-11-15 JO JO2001188A patent/JO2307B1/en active
- 2001-11-19 PE PE2001001154A patent/PE20020760A1/es not_active Application Discontinuation
- 2001-11-21 PA PA20018533501A patent/PA8533501A1/es unknown
- 2001-11-21 GT GT200100232A patent/GT200100232A/es unknown
- 2001-11-21 AR ARP010105423A patent/AR031486A1/es not_active Application Discontinuation
- 2001-11-21 UY UY27034A patent/UY27034A1/es not_active Application Discontinuation
-
2003
- 2003-05-01 IL IL155705A patent/IL155705A/en not_active IP Right Cessation
- 2003-05-07 ZA ZA200303517A patent/ZA200303517B/en unknown
- 2003-05-08 HR HR20030362A patent/HRP20030362A2/xx not_active Application Discontinuation
- 2003-05-21 NO NO20032291A patent/NO324865B1/no unknown
- 2003-05-21 EC EC2003004619A patent/ECSP034619A/es unknown
- 2003-05-22 MA MA27173A patent/MA26967A1/fr unknown
- 2003-05-22 BG BG107840A patent/BG107840A/bg unknown
-
2005
- 2005-11-11 HK HK05110085A patent/HK1078079A1/xx not_active IP Right Cessation
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