YU174490A - Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja - Google Patents

Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja

Info

Publication number
YU174490A
YU174490A YU174490A YU174490A YU174490A YU 174490 A YU174490 A YU 174490A YU 174490 A YU174490 A YU 174490A YU 174490 A YU174490 A YU 174490A YU 174490 A YU174490 A YU 174490A
Authority
YU
Yugoslavia
Prior art keywords
compounds
quateral
preparation
well
carboxylic acid
Prior art date
Application number
YU174490A
Other languages
English (en)
Other versions
YU47800B (sr
Inventor
R. Banholzer
R. Bauer
R. Reichl
Original Assignee
Boehringer Ingelheim Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6389619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU174490(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Kg. filed Critical Boehringer Ingelheim Kg.
Priority to SI9011744A priority Critical patent/SI9011744B/sl
Publication of YU174490A publication Critical patent/YU174490A/sh
Priority to HRP-1744/90A priority patent/HRP940723B1/xx
Publication of YU47800B publication Critical patent/YU47800B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Disintegrating Or Milling (AREA)
  • Glass Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Novi estri tienil-karboksilne kisline z aminoalkoholi, njihovi kvaternirni produkti kot tudi priprava in uporaba teh spojin Opisane so nove spojine s formulo I v kateri A stoji za skupino v kateri m in n neodvisno drug od drugega pomenita 1 ali 2, Q eno izmed dvoveznih skupin in Q' predstavlja skupino = NR ali skupino = NRR', pri čemer R pomeni H ali v danem primeru s halogenom ali hidroksi substituiran C1-C4 alkilni ostanek, R' pa C1-C1-alkilni ostanek in R in R' lahko skupaj tvorita tudi C4-C6-alkilenski ostanek in pri čemer pri kvarternih spojinah stoji nasproti pozitivnega naboja N-atoma ekvivalent aniona (X-), R1 stoji za tienilni, fenilni, furilni, ciklopentilni ali cikloheksilni ostanek, pri čemer so ti ostanki lahko tudi substituirani z metilom, tienil in fenil pa tudi s fluorom ali klorom, R2 stoji za vodik, OH, C1C4-alkoksi ali C1-C4-alkil, Ra stoji za H, F, Cl ali CH3, in v kolikor = NR pomeni sekundarno ali terciarno amino skupino, tudi njihove kislinske adicijske soli, ki se dajo pripraviti po samih po sebi znanih metodah in so uporabne kot učinkovine za zdravila.
YU174490A 1989-09-16 1990-09-13 Estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje tih jedinjenja YU47800B (sr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9011744A SI9011744B (sl) 1989-09-16 1990-09-13 Novi estri karboksilne kisline z amino-alkoholi, njihovi kvarternirni produkti kot tudi priprava in uporaba teh spojin
HRP-1744/90A HRP940723B1 (en) 1989-09-16 1994-10-21 New thienylcarboxylic acid esters of aminoalcohols, their quarternary products, their preparation and use of the compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3931041A DE3931041C2 (de) 1989-09-16 1989-09-16 Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
YU174490A true YU174490A (sh) 1993-10-20
YU47800B YU47800B (sr) 1996-01-09

Family

ID=6389619

Family Applications (1)

Application Number Title Priority Date Filing Date
YU174490A YU47800B (sr) 1989-09-16 1990-09-13 Estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje tih jedinjenja

Country Status (33)

Country Link
US (1) USRE39820E1 (sh)
EP (1) EP0418716B1 (sh)
JP (1) JPH0730074B2 (sh)
KR (1) KR0168432B1 (sh)
AT (1) ATE103914T1 (sh)
AU (1) AU642913B2 (sh)
BG (1) BG61295B2 (sh)
CA (1) CA2066248C (sh)
CZ (1) CZ284589B6 (sh)
DD (1) DD297647A5 (sh)
DE (3) DE3931041C2 (sh)
DK (1) DK0418716T3 (sh)
ES (1) ES2052125T3 (sh)
FI (1) FI114395B (sh)
HR (1) HRP940723B1 (sh)
HU (2) HU208823B (sh)
IE (1) IE65528B1 (sh)
IL (1) IL95691A (sh)
LU (1) LU90949I2 (sh)
MX (1) MX9203150A (sh)
NL (1) NL300084I2 (sh)
NO (2) NO301478B1 (sh)
NZ (1) NZ235306A (sh)
PH (1) PH31617A (sh)
PL (1) PL168468B1 (sh)
PT (1) PT95312B (sh)
RU (1) RU2073677C1 (sh)
SI (1) SI9011744B (sh)
SK (1) SK279453B6 (sh)
UA (1) UA41272C2 (sh)
WO (1) WO1991004252A1 (sh)
YU (1) YU47800B (sh)
ZA (1) ZA907338B (sh)

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