WO2022099437A1 - Functional material automation platform based on robot and material interface genetic engineering - Google Patents

Abstract

A functional material automation platform based on a robot and material interface genetic engineering. The platform comprises: a first operation area, a second operation area, a third operation area, a first manipulator, a second manipulator and a third manipulator, wherein the first manipulator transfers materials between the three operation areas; the second manipulator is used for extracting, transferring and mixing materials in the second operation area; and the third manipulator is used for extracting, transferring and mixing materials in the third operation area.

Description

Functional material automation platform based on genetic engineering of robot and material interface technical field

The invention relates to the fields of high-end equipment manufacturing, new materials, intelligent manufacturing, new generation information technology and biotechnology, and in particular, to a new type of high-performance energy and environmental protection, biomedicine and electronic information related fields that combine robots and digital manufacturing. Functional material structure design , Prepare and evaluate "islands" of different functional divisions and their overall platforms.

Background technique

At present, the biochemical synthesis and preparation of high-performance materials in the fields of energy and environmental protection, biomedicine and electronic information are still labor-intensive, and some preparation methods and steps have errors or ambiguities. Therefore, it is necessary to develop new materials by "scientific intuition" The traditional mode of "trial and error" is transformed to a new mode of "theoretical prediction combined with experimental verification", which comprehensively improves the speed of functional materials from discovery to application and reduces costs.

In addition, the traditional research and development process of functional materials is costly and time-consuming, and has high requirements for the efficiency and repeatability of experiments. The inefficiency and waste of experiments will be a great consumption of research costs and talents. If only relying on manual manual operation will not only consume time and physical strength, but also more prone to errors, which will greatly affect the repeatability of experimental results. On the other hand, traditional methods have obvious deficiencies in predicting the relationship between material properties, composition, and processing conditions. In addition, some toxic solid reagents have great risks in the process of extraction and weighing, which may not only cause harm to experimenters, but also cause uncontrollable pollution to the environment.

With the vigorous development of information science in the 21st century, data-intensive scientific discovery (Data-intensive Scientific Discovery) is becoming the "fourth research paradigm". Exploring the intersection of Fourth Paradigm and high-end equipment manufacturing, new materials, intelligent manufacturing, next-generation information technology, and biological technology fields will help solve key scientific problems in the fields of biomedicine and electronic information, as well as the development of "stuck neck" technology. Breakthrough provides a whole new methodology. The research and development of functional materials in the fields of traditional biomedicine and electronic information requires the synthesis and testing of massive molecules, which is one of the key bottlenecks in research and development.

Therefore, combined with the most cutting-edge technologies in current discipline development, a functional material automation platform based on "human-artificial intelligence-robot" collaboration based on genetic engineering of the robot and material interface; a digital automation multi-functional platform for robotic chemists; digital biochemical functional material preparation The smart island is of great significance. It will open up the rapid development of new functional materials in energy and environmental protection, electronic information, and biomedical technology, as well as their intersections, and provide a solid foundation for the development of strategic emerging industries such as energy, information, high-end equipment manufacturing, and human health. The theoretical basis and technical support of biochemical materials will promote the establishment of a cloud-based, IT-based, data-based, AI-based, automated, and high-performance material data element market for biochemical material synthesis.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a functional material automation platform based on the genetic engineering of the interface between robots and materials, which solves the labor-intensive biochemical synthesis and preparation of high-performance materials in the prior art, and the errors or ambiguities in the methods and steps. , the lack of digital normative problems, realize the iterative innovation of new functional materials of digital "design-test-representation-learning-redesign".

The technical solution of the present invention to solve the above problems is: an automatic platform for structural design, preparation and evaluation of functional materials in the fields of digital high-performance energy and environmental protection, biomedicine and electronic information, and its special features are:

Including a first operation area, a second operation area, a third operation area, and a first manipulator;

The first operation area includes a storage area, a temperature control area, an analysis area, and a centrifugal area;

The second operation area includes a second manipulator, an illumination area, a preparation area, a reaction area, a vibration area, a pipette head collection area, a pipette head placement area, a raw material box and a substrate box;

The third operation area includes the interaction area and the third manipulator;

The first manipulator is used to transfer materials between the first operation area, the second operation area and the third operation area;

The second manipulator is used for extracting, transferring and mixing the materials in the second operation area;

The third manipulator is used to extract and transfer materials in the third operation area.

Further, a monitoring device is also included. The monitoring device is arranged at the lower part of the first operation area and the second operation area. The monitoring device includes a camera and a motion device, and the motion device drives the camera to move.

Further, it also includes a host computer, the host computer controls the first manipulator, the second manipulator, and the third manipulator to perform actions, and the host computer is connected to the monitoring device for acquiring image information collected by the monitoring device.

Further, the above-mentioned storage area includes a pipette head storage area, a substrate storage area and a waste storage area.

Further, the above-mentioned temperature control zone includes a constant temperature zone and a room temperature zone, the constant temperature zone includes a constant temperature box, the constant temperature box includes a constant temperature box, and the constant temperature box uses a first cylinder to control opening and closing.

Further, the above-mentioned first manipulator includes a moving base, a rotating mechanism, a vertical motion mechanism, a telescopic mechanism and a clamping jaw;

The rotation mechanism is fixed on the moving base, the vertical movement mechanism is arranged on the rotation mechanism, the telescopic mechanism is arranged on the vertical movement mechanism, and the clamping claw is fixed at the end of the telescopic mechanism.

The moving base drives the rotating mechanism to move, the rotating mechanism drives the vertical motion mechanism and the telescopic mechanism set on it to adjust the angle, the vertical motion mechanism drives the telescopic mechanism to move up and down to reach the preset height, and the telescopic mechanism drives the gripper to grab the material , and then transfer.

Further, the structure of the above-mentioned third manipulator is the same as that of the first manipulator.

Further, the second manipulator includes a three-axis mechanism and a material extraction device arranged on the three-axis mechanism, and the material extraction device is used for extracting and transferring materials in the second operation area;

The three-axis mechanism includes an x-direction motion mechanism, a y-direction motion mechanism and a z-direction motion mechanism, the z-direction motion mechanism includes a fixed plate, and the material extraction device is arranged on the fixed plate.

Further, there are at least two material extraction devices, and the material extraction device includes a moving rod, a moving cylinder and a pipetting gun, the moving rod and the moving cylinder are fixed on the fixed plate, and the moving cylinder drives the moving rod to move up and down, pipetting liquid. The gun is set at the end of the moving rod.

Further, the illumination area includes a UV lamp, and the upper part of the preparation area and the reaction area is provided with a shadowless lamp.

Further, a vibration motor is provided at the bottom of the above-mentioned vibration area.

Further, a plurality of transparent porous reaction plates are arranged on the above-mentioned illumination area, preparation area, reaction area, and vibration area, and a plurality of reaction holes are arranged on the porous reaction plate.

Further, the above-mentioned raw material box is used for placing different stock solutions and/or raw materials, the raw material box is in the shape of a transparent cuboid, and the upper end of the raw material box is open.

Further, the above-mentioned waste storage area includes a waste collection area slot, and the waste collection slot is rectangular.

Advantages of the present invention:

The invention adopts the manipulator to replace the operator for material extraction and sample preparation, which greatly reduces the labor intensity of the operator, saves time, and can improve the accuracy of the experiment;

In the present invention, the upper computer can be used to control each movement mechanism and monitoring mechanism, so as to avoid injury to the operator during the experiment;

The present invention conducts high-throughput (that is, a large number of repeated operations in a short period of time) tests through the device, thereby saving cost and time, and shortening the research and development of functional materials that originally took years or even decades to complete to several months;

The invention can also realize the research and development of not only biomedicine, but also electronic information, energy and environmental protection materials through the free combination of each partition module, and provide guidance data.

Description of drawings

Fig. 1 is the overall structure diagram of the functional material automation platform based on the genetic engineering of robot and material interface of the present invention;

Fig. 2 is another direction view of Fig. 1;

Fig. 3 is the operation flow chart of the present invention;

Fig. 4 is the structure diagram of the second operation area in Fig. 1;

Fig. 5 is another direction view of Fig. 4;

Fig. 6 is the structure diagram of the material extraction device in Fig. 1;

Fig. 7 is a structural diagram of the monitoring device in Fig. 1;

Fig. 8 is the structure diagram of the first manipulator in Fig. 1;

Fig. 9 is the structure diagram of illumination area in Fig. 1;

FIG. 10 is a structural diagram of the constant temperature zone in FIG. 1 .

1. The first operation area, 2. The second operation area, 3. The third operation area, 4. The first manipulator, 5, the analysis area, 6, the centrifugal area, 7, the second manipulator, 8, the illumination area, 9, Preparation area, 10, reaction area, 11, vibration area, 12, pipette head collection area, 13, pipette head placement area, 14, raw material box, 15, substrate box, 16, interaction area, 17, third manipulator , 18, camera, 19, motion device, 20, pipette head storage area, 21, substrate storage area, 22, waste storage area, 23, constant temperature area, 24, room temperature area, 25, mobile base, 26, rotation Mechanism, 27, vertical motion mechanism, 28, telescopic mechanism, 29, gripper, 30, x-direction motion mechanism, 31, y-direction motion mechanism, 32, z-direction motion mechanism, 33, fixed plate, 34, moving rod, 35, mobile cylinder, 36, pipette gun, 37, vibration motor, 38, porous reaction plate, 39, incubator cover, 40, first cylinder, 41, UV lamp, 42, timing belt, 43, motor, 44, The second cylinder, 45, U-shaped track, 46, refrigerator.

Detailed ways

In order to make the purposes, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments These are some embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention. Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention.

Referring to Fig. 1-Fig. 3, a functional material automation platform based on genetic engineering of the interface between robots and materials, including a desktop platform, on which a first operation area 1, a second operation area 2, a third operation area 3, and a first operation area are arranged. A manipulator 4, a monitoring device. The first operation area 1 includes a storage area, a temperature control area, an analysis area 5, and a centrifugal area 6; the second operation area 2 includes a second manipulator 7, an illumination area 8, a preparation area 9, a reaction area 10, a vibration area 11, The pipette head collection area 12 , the pipette head placement area 13 , the raw material box 14 and the substrate box 15 ; the third operation area 3 includes an interaction area 16 and a third manipulator 17 . The first manipulator 4 is used to transfer materials between the first operation area 1 , the second operation area 2 and the third operation area 3 ; the second manipulator 7 is used to extract the materials in the second operation area 2 , transfer and mixing; the third manipulator 17 is used to extract, transfer and mix the materials in the third operation area 3 .

The bottom of the tabletop platform has wheels for easy movement.

As a preferred embodiment of the present invention, it also includes a host computer, the host computer controls the first manipulator 4, the second manipulator 7, and the third manipulator 17 to perform actions, the host computer is connected with the monitoring device, and is used to obtain the data collected by the monitoring device. image information. The upper computer can be a computer that acquires, stores and displays the information it acquires. The upper computer includes an intelligent control and analysis center, uploads the data collected by the monitoring device and the analysis area 5 to the database therein, performs calculation, analysis and machine learning through the software, and outputs the calculation results according to the preset model in the software to achieve high-pass quantity test.

As a preferred embodiment of the present invention, referring to FIGS. 1-3 and 10 , the storage area includes a pipette head storage area 20 , a substrate storage area 21 and a waste storage area 22 .

The temperature control zone includes a constant temperature zone 23 and a room temperature zone 24 . The constant temperature zone 23 includes three constant temperature boxes, which can test samples at different temperatures at the same time. A temperature adjustment device and a temperature sensor are arranged in the incubator. The temperature sensor acquires the temperature parameters of the incubator and transmits it to the upper computer, and the upper computer adjusts the temperature of the incubator through the temperature adjustment device. The incubator cover 39 of the incubator is controlled by an air cylinder, which opens or closes it.

The illumination area 8, the preparation area 9, the reaction area 10, and the vibration area 11 are provided with a number of transparent porous reaction plates 38, the porous reaction plate 38 is provided with a number of reaction holes, and the hole reaction plate 38 can use 96 holes. plate. The raw material box 14 is used for placing different stock solutions and/or raw materials, the raw material box 14 is in the shape of a transparent cuboid, and the upper end of the raw material box 14 is open; the waste storage area 22 includes a waste collection area slot, the waste collection The slot is rectangular. Analysis zone 5 includes a microplate reader.

Referring to FIG. 8 , as a preferred embodiment of the present invention, the first manipulator 4 includes a moving base 25 , a rotating mechanism 26 , a vertical motion mechanism 27 , a telescopic mechanism 28 and a gripper 29 . The rotating mechanism 26 is fixed on the moving base 25 , the vertical motion mechanism 27 is provided on the rotating mechanism 26 , the telescopic mechanism 28 is provided on the vertical motion mechanism 27 , and the clamping jaw 29 is fixed on the end of the telescopic mechanism 28 .

The power device and the transmission device of the moving base 25 can be realized in the form of a motor driven roller; the rotating mechanism 26 adopts a stepping motor to realize precise control of the rotation angle; the vertical motion mechanism 27 adopts a linear motor to realize, and its stator is vertically arranged on the rotating mechanism 26, the mover base is connected with the telescopic mechanism 28; the telescopic mechanism 28 includes three rotating arms, and the adjacent two rotating arms are connected by a stepping motor to control the rotation accuracy, and the clamping jaw 29 is connected with the last rotating arm .

The first manipulator 4 is used to transfer the pipetting heads, substrates, raw materials, samples, etc. in the first operation area, the second operation area 2, and the third operation area 3. For example, the first manipulator 4 uses the air gripper 29 to transfer the sample in the preparation area 9 in the second operation area 2 to the interaction area of the third operation area 3 .

Referring to FIGS. 1 and 2 , the structure of the third manipulator 17 is similar to that of the first manipulator 4 . The difference is that its moving base moves on a preset U-shaped track 45 , and a film is also provided on the third operation area 3 machine or refrigerator 46 and other equipment, the third manipulator 17 is used to transfer the items in the interaction area 16, and has been sent to the film laminating machine or the refrigerator 46 for storage.

As an embodiment of the present invention, referring to FIG. 4 and FIG. 5 , the second manipulator 7 includes a three-axis mechanism and a material extraction device arranged on the three-axis mechanism, and the material extraction device is used to remove the second operation area 2 The material inside is extracted and transferred. The three-axis mechanism includes an x-direction motion mechanism 30 , a y-direction motion mechanism 31 and a z-direction motion mechanism 32 . The z-direction motion mechanism 32 includes a fixed plate 33 on which the material extraction device is arranged.

The three-axis mechanism is arranged on a frame, and the frame is located at the upper part of the second operation area 2. The x-direction motion mechanism 30, the y-direction motion mechanism 31 and the z-direction motion mechanism 32 all use linear motors, and the stator guide rail of the x-direction motion mechanism 30 is set on the On the frame, the mover seat is provided with a y-direction motion mechanism 31. In order to increase stability, a guide rail parallel to the stator guide rail is also provided on the frame. The stator guide rail of the y-direction motion mechanism 31 is perpendicular to the stator guide rail of the x-direction motion mechanism 30. The stator guide rail of the z-direction motion mechanism 32 is fixed on the mover seat of the y-direction motion mechanism 31 , and the material extraction device is fixed on the mover seat of the z-direction motion mechanism 32 through the fixing plate 33 .

4 and 6, as a preferred embodiment of the present invention, in order to improve the efficiency of pipetting and shorten the experiment time, there are at least two material extraction devices, and the material extraction device includes a moving rod 34, a moving cylinder 35 and a moving cylinder 35. Liquid Gun 36. The moving rod 34 and the moving cylinder 35 are fixed on the fixed plate 33 , the moving cylinder 35 drives the moving rod 34 to move up and down, and the pipetting gun 36 is arranged at the end of the moving rod 34 .

If necessary, the unused pipette can be moved up by moving the cylinder 35, so as to avoid the unused pipette from interfering with the experiment when the pipette moves left and right. When multiple pipettes are required, the pipette 36 is moved down by moving the cylinder 35 .

Referring to FIG. 9 , as a preferred embodiment of the present invention, the illumination area 8 includes a UV lamp 41 of 365 nm and a porous reaction plate, the UV lamp 41 is located on the porous reaction plate, and the UV lamp 41 and the first cylinder 40 are telescopic The rod is connected, and the telescopic rod drives the UV lamp 41 to move back and forth on its corresponding porous reaction plate, so as to provide UV light.

As a preferred embodiment of the present invention, the vibrating zone 11 includes a porous reaction plate, and a vibrating motor 37 is provided at the bottom of the vibrating zone 11 . The vibrating motor 37 vibrates to accelerate the liquid mixing and shorten the time required for the test.

Referring to FIGS. 4 and 7 , as a preferred embodiment of the present invention, the monitoring device is arranged at the lower part of the first operating area 1 and the second operating area 2 , and the monitoring device includes a camera 18 and a motion device 19 , and the motion device 19 drives the Camera 18 moves. The upper parts of the first operation area 1 and the second operation area 2 are provided with shadowless lamps. The shadowless lamp can prevent the reaction wells of the multi-hole reaction plate from interacting with each other due to the difference in light when taking pictures, resulting in more shadows in the photo imaging, and the original shadows are covered by the shadowless lamp. This makes the photos taken in real time clearer, and at the same time, it is more convenient for the intelligent control analysis center in the background to distinguish the color reactions generated in the multi-hole reaction plate, so as to facilitate machine learning.

Taking the monitoring device in the lower part of the second operation area 2 as an example, the movement device 19 includes a lateral movement mechanism and a longitudinal movement mechanism. The longitudinal movement mechanism includes a second cylinder 44, the lateral movement mechanism includes a motor 43, the motor 43 drives the synchronous belt 42 to rotate, the synchronous belt drives the camera 18 to move, and the second cylinder 44 drives the lateral movement mechanism to move forward and backward. The camera 18 adopts a 500w color camera, and the lens is a fixed-focus lens, which will not change the focal length with the change of image brightness, so as to ensure the comparability between images, and is equipped with an anti-distortion lens.

Example 1:

Use of the present invention for the preparation of MOFs proteins

Step 1: Use the first manipulator 4 to add 1000 μl each of ligand A, B and C solutions, 1000 μl each of five metal ions (Cu ²⁺ , Zn ²⁺ , Co ²⁺ , Ni ²⁺ and Cd ²⁺ ), enzyme 500 μl of the solution was transferred to a 96-well deep-well plate in the storage area of the raw material box 14 as the raw material area stock solution.

The second step: use the second manipulator 7 to suck and transfer the five metal ions (Cu ²⁺ , Zn ²⁺ , Co ²⁺ , Ni ²⁺ and Cd ²⁺ ) in the raw material box 14 and place them in the 96-well plate of the preparation area 9 , repeat 3 times.

The third step: use the second manipulator 7 to suck and transfer 50 μl of the enzyme solution and place it in the same well position as in the preparation area of the second step.

Step 4: Use the second manipulator 7 to suck and transfer 50 μl of each of the ligands A, B and C solutions into a 96-well plate in the preparation area 9, mix with metal ions, and ensure that the three ligands and each metal ion are fully Mix and react, and oscillate by moving the robotic arm to the vibration zone.

Step 5: The motor 43 is started, and the camera 18 is driven to take pictures to observe the color change of the solution in the 96-well plate in different preparation areas 9.

Step 6: Using the second manipulator 7, transfer 50ul of syringaldazine and 10ul of buffer to the same well of the 96-well plate in reaction zone 10 at a time, and repeat 15 times.

The seventh step: using the second manipulator 7 to suck and transfer the 15 kinds of reaction solutions generated in the fourth step to the 15 wells of the sixth step reaction zone 10 and mix them thoroughly.

Step 8: Use the first manipulator 4 to transfer the 96-well plate in Step 7 to the microplate reader in the analysis area 5 for data analysis and kinetic monitoring.

Step 9: Export data from the microplate reader for enzyme activity analysis.

The tenth step: use the first manipulator 4 to transfer the remaining reaction solution of the 96-well plate to the centrifugation zone 6 for centrifugation, and then evaluate and analyze the solid.

The above steps will move to the pipette head storage area 20 to replace the pipette tips after sucking different liquids through the pipette gun 36 as needed.

Example 2:

1. The second manipulator 7 operates the pipette 36 to suck up 1-10ml of the saturated DMF solution (X=F, Cl or Br) of PbX ₂ and CsX in the substrate box 15, respectively, and add them to the precursor liquid sample tank in the raw material box 14. .

2. The second manipulator 7 operates the pipette 36 to absorb long carbon chain organic acids (10-20 carbon content) and long carbon chain small molecular amines (10-20 carbon content) in the substrate box 15, and the suction volume is 0.1 Between -2ml, add it to the precursor liquid sample tank in the raw material box 14.

3. The second manipulator 7 operates the pipette gun 36 to repeatedly suck-release the precursor liquid sample in the raw material box 15 to make it evenly mixed.

4. The second manipulator 7 operates the pipetting gun 36 to absorb the solvent (including but not limited to toluene, chloroform, n-hexane, ethyl acetate, etc.) and add it to the 96-well plate of the vibration zone 11, and the feeding volume is between 1-20ml, It is used as a poor solvent for the subsequent preparation of perovskite quantum dots.

5. The vibration motor 37 turns on the vibration mode, and the second manipulator 7 operates the pipette gun to absorb 0.1-1 ml of the precursor liquid in the raw material box, and add it to the poor solvent at a preset speed to rapidly synthesize perovskite quantum dots.

6. Every one minute, stop the vibration times, use the camera 18 to photograph the material under visible light, and then place the 96-well plate in the lighted area of the UV lamp 41 by the first manipulator 4, and use the camera 18 in the wavelength range of 365-395nm. material to shoot.

7. After each shooting, the first manipulator 4 puts the 96-well plate back into the vibration area to continue the vibration reaction, and the total reaction time is 30 minutes.

8. After the reaction, the first manipulator 4 puts the 96-well plate into the microplate reader to test the light absorption properties of the material.

9. After all the tests are completed, the first manipulator 4 will transfer the 96-well plate to the interactive area 16 , and the third manipulator 17 will film and seal the 96-well plate, and store the samples in the refrigerator 46 .

10. Then, the intelligent computing system in the host computer will digitally analyze the photos taken, convert all the information captured into data and process them graphically, and obtain the curve of the luminescence and absorption properties of the sample over time, as well as the relationship between different materials. performance difference.

11. At the same time, the intelligent image processing system in the host computer will cut and splicing the pictures, summarize and horizontally arrange the pictures of the same sample at different times, and vertically arrange the summary charts of different samples to form a material luminescence change with time. The color matrix is convenient to summarize and analyze the change law of the sample more intuitively.

Note: The entire operation process is automatically completed by the upper computer controlled manipulator according to the set program. Every time a different liquid is sucked by the pipette, it will be moved to the pipette head storage area 20 to replace the pipette head.

This application focuses on the automatic preparation technology and device of functional materials realized by the upper computer control automation platform. Through the top-level design and interactive linkage of the two, the cooperation similar to the "body" and "brain" is initially realized, enabling the automatic preparation technology of functional materials and The specific research content and technical route are as follows:

Using the host computer as the "brain", effectively using the existing large databases of materials (for example, Materials Project and CCDC, etc.) and developing targeted data mining programs, applying machine learning to achieve preliminary screening of data-driven materials; using quantum chemical calculations such as VASP and CP2K Program and develop high-throughput calculation programs, select descriptors (Descriptors) suitable for the catalytic system, realize high-throughput calculation screening and build a database; build a mathematical model for crystal phase prediction (such as inverse Wulff model, etc.), realize simulation prediction SEM Build a database with TEM diffraction spot patterns; design effective in-situ rapid characterization experiments of material interfaces (such as in-situ Raman, etc.) to realize the study of functional material interface characteristics and build a database; further expand high-throughput theoretical calculations - high-throughput original Bit Characterization Experiment-Functional Materials Interface Genome Proprietary Database and Machine Learning Analysis Platform.

Taking the functional material automatic preparation platform of this application as the "body", under the guidance of the functional material interface genome engineering, expand the innovative application of the Industry 4.0 method in the functional material preparation technology, and integrate mechanical, electronic and mechanical under the background of "new infrastructure" construction. , information and other technical achievements, through the design of desktop robotic arms/robots, and the initial construction of automation modules such as pipetting, stirring, vibration, heating, calcination, video monitoring, etc., to achieve high-throughput, high-precision, high-output automation of different functional materials Preparation, build a desktop robot automatic preparation device for functional materials modularized with different process lines.

Through the cooperation of "body" and "brain", the automatic preparation technology and device ("digital body") of functional materials is realized. Based on intelligent, automatic and high-throughput devices, combined with the in-depth research and development of design software and machine learning, the integration of functional materials Interface the genome and empower the automated preparation platform, the "body" carries out high-throughput experimental data to supplement the "brain", and completes the closed loop of "design-characterization-test-learn-redesign" quickly, at low cost, and in multiple cycles, realizing functional materials. Rational design, controllable synthesis and iterative innovation of specific functional materials for automated preparation of modular device "digital bodies".

In the present invention, the manipulator is used instead of the operator to perform material extraction and sample preparation, which greatly reduces the labor intensity of the operator, saves time, and can improve the accuracy of the experiment; control to avoid injury to the operator during the experiment; the present invention conducts high-throughput (that is, a large number of repeated operations in a short period of time) experiment through the device, thereby saving cost and time, making the original need for several years or even decades. The research and development of functional materials that can only be completed can be shortened to several months; the present invention can also realize the research and development of not only biomedicine, but also electronic information, energy and environmental protection materials through the free combination of each partition module, and provide guidance data.

The above descriptions are only the embodiments of the present invention, and are not intended to limit the protection scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the description and drawings of the present invention, or directly or indirectly applied to other related The system field is similarly included in the protection scope of the present invention.

Claims (12)

1. A functional material automation platform based on genetic engineering of robot and material interface, characterized in that:

   comprising a first operation area (1), a second operation area (2), a third operation area (3), and a first manipulator (4);

   The first operation area (1) includes a storage area, a temperature control area, an analysis area (5), and a centrifugal area (6); the second operation area (2) includes a second manipulator (7), an illumination area (8), Preparation area (9), reaction area (10), vibration area (11), pipette head collection area (12), pipette head placement area (13), raw material box (14) and substrate box (15); The three operation areas (3) include an interaction area (16) and a third manipulator (17);

   The first manipulator (4) is used to transfer materials between the first operation area (1), the second operation area (2) and the third operation area (3);

   The second manipulator (7) is used to extract, transfer and mix the materials in the second operation area (2);

   The third manipulator (17) is used to extract, transfer and mix the materials in the third operation area (3).
2. A kind of functional material automation platform based on the genetic engineering of robot and material interface according to claim 1, is characterized in that:

   Also includes a monitoring device, the monitoring device is arranged at the lower part of the first operation area (1) and the second operation area (2), the monitoring device includes a camera (18) and a motion device (19), the motion device (19) drives the camera (18) MOVE.
3. A kind of functional material automation platform based on genetic engineering of robot and material interface according to claim 2, is characterized in that:

   It also includes a host computer, the host computer controls the first manipulator (4), the second manipulator (7), and the third manipulator (17) to perform actions, and the host computer is connected with the monitoring device for acquiring image information collected by the monitoring device.
4. A kind of functional material automation platform based on the genetic engineering of robot and material interface according to any one of claims 1-3, it is characterized in that:

   The storage area includes a pipette head storage area (20), a substrate storage area (21) and a waste storage area (22).
5. A kind of functional material automation platform based on the genetic engineering of robot and material interface according to any one of claims 1-3, it is characterized in that:

   The temperature control zone includes a constant temperature zone (23) and a room temperature zone (24), the constant temperature zone (23) includes a constant temperature box, the constant temperature box includes a constant temperature box 39, and the constant temperature box 39 uses a first cylinder (40) to control opening and closing.
6. A kind of functional material automation platform based on the genetic engineering of robot and material interface according to any one of claims 1-3, it is characterized in that:

   The first manipulator (4) comprises a moving base (25), a rotating mechanism (26), a vertical motion mechanism (27), a telescopic mechanism (28) and a clamping jaw (29);

   The rotation mechanism (26) is fixed on the moving base (25), the vertical movement mechanism (27) is arranged on the rotation mechanism (26), the telescopic mechanism (28) is arranged on the vertical movement mechanism (27), and the clamping jaws ( 29) is fixed at the end of the telescopic mechanism (28).
7. A kind of functional material automation platform based on the genetic engineering of robot and material interface according to any one of claims 1-3, it is characterized in that:

   The second manipulator (7) includes a three-axis mechanism and a material extraction device arranged on the three-axis mechanism, and the material extraction device is used for extracting and transferring materials in the second operation area (2);

   The three-axis mechanism includes an x-direction motion mechanism (30), a y-direction motion mechanism (31), and a z-direction motion mechanism (32). The z-direction motion mechanism (32) includes a fixed plate (33), and the material extraction device is arranged on the fixed plate ( 33) on.
8. A kind of functional material automation platform based on genetic engineering of robot and material interface according to claim 7, is characterized in that:

   There are at least two material extraction devices, and the material extraction device includes a moving rod (34), a moving cylinder (35) and a pipetting gun (36),

   The moving rod (34) and the moving cylinder (35) are fixed on the fixed plate (33), the moving cylinder (35) drives the moving rod (34) to move up and down, and the pipetting gun (36) is arranged on the side of the moving rod (34). end.
9. A kind of functional material automation platform based on the genetic engineering of robot and material interface according to any one of claims 1-3, it is characterized in that:

   The illumination area (8) includes a UV lamp (41), a shadowless lamp is provided on the upper part of the preparation area (9) and the reaction area (10), and the UV lamp (41) is connected with the telescopic rod of the first air cylinder (40), and the telescopic rod drives the The UV lamp (41) moves back and forth to provide UV light.
10. A kind of functional material automation platform based on the genetic engineering of robot and material interface according to any one of claims 1-3, it is characterized in that:

    A vibration motor (37) is provided at the bottom of the vibration area (11).
11. A kind of functional material automation platform based on the genetic engineering of robot and material interface according to any one of claims 1-3, it is characterized in that:

    A plurality of transparent porous reaction plates (38) are arranged on the illumination area (8), the preparation area (9), the reaction area (10), and the vibration area (11), and the porous reaction plates (38) are provided with a plurality of transparent porous reaction plates (38). several reaction wells.
12. A kind of functional material automation platform based on the genetic engineering of robot and material interface according to any one of claims 1-3, it is characterized in that:

    The raw material box (14) is used for placing different stock solutions and/or raw materials, the raw material box (14) is in the shape of a transparent cuboid, and the upper end of the raw material box (14) is open;

    The waste storage area (22) includes a waste collection area slot which is rectangular in shape.

Images