WO2018052181A1

WO2018052181A1 - Microneedle patch applicator

Info

Publication number: WO2018052181A1
Application number: PCT/KR2017/006349
Authority: WO
Inventors: 김홍기; 이부용; 김태형; 김정동; 정도현
Original assignee: 주식회사 라파스
Priority date: 2016-09-13
Filing date: 2017-06-16
Publication date: 2018-03-22
Also published as: KR101746048B1

Abstract

A microneedle patch applicator (20) according to the present invention comprises: a main body (21); a band (30) attached to the main body (21) so as to connect the main body (21) to the body of a user; a slot (22) formed on the side surface of the main body (21); and a cylinder (23) for downwardly pressing a microneedle patch (10) inserted into the slot (22). The microneedle patch (10) is attached to an insertion support (11) by passing through coupling points formed along the outer periphery thereof, such that the insertion support (11) encompasses the microneedle patch (10) in a coupled state. In addition, the microneedle patch (10) is inserted into the slot (22) while being attached to the insertion support (11), and the coupling points are broken when the patch is downwardly pressed by the cylinder (23), such that the microneedle patch (10) is pressed to the skin of the user in a state in which coupling with the insertion support (11) is released. The pressed state is maintained until a separate releasing operation is performed. The microneedle patch (10) is made from a flexible material applicable to curved skin of the user, and the insertion support (11) is made from a material capable of maintaining the shape for insertion into the slot (22) in a state in which the microneedle patch (10) is coupled thereto.

Description

Microneedle Patch Applicator

The present invention relates to a microneedle patch applicator.

The skin covers the outside of the living body and protects the muscles and organs in the body. It is composed of three layers of epidermis, dermis and subcutaneous fat layer from the outside. It has a function.

The epidermis is mainly composed of keratinocytes, but also melanocytes, Langerhans cells, atypical cells, and Merkel cells. Of these, the stratum corneum is the first human body to perform barrier function (selective permeation barrier, physical barrier, ultraviolet barrier, harmful substance barrier, microbial barrier), moisturizing function, immune function, antioxidant function, anti-inflammatory function, antibacterial function, regenerative function, etc. It is a shield.

Under the stratum corneum and granule layer, there is a waterproof membrane, but most of the active substance does not pass through the waterproof membrane. To overcome this, 1) reduce the particle size of the active material or pass it through the addition of nanocarriers together, 2) pass through the waterproof membrane using physical, chemical and mechanical methods, or 3) form the liposome, nanoemulsion, nano It was configured in the form of particles to allow passage through the stratum corneum. The products that maintain the intercellular lipid layer, which is the most important for the stratum corneum and moisturizing function of the stratum corneum, and infiltrate the active substances, the material itself should be amphiphilic (nano-oil water type), the size of 100nm or less, molecular weight 500 Dalton or less Can pass through the lipid layer.

As such, the delivery of the drug through the skin to the body is very difficult to deliver the desired substance unless it passes through the stratum corneum, the primary barrier. Ointments and creams developed for the treatment of dermatological diseases are designed to deliver drugs through these stratum corneum and to have the proper effect on the target area. However, as described above, even if the molecular weight of the drug exceeds 500 Daltons or its structure is difficult to pass through the stratum corneum, even if it is well designed, it is not easy to expect the desired purpose and efficacy because it is actually delivered to the skin.

Therefore, microneedle technology has been commercialized and used to form artificial channels in the stratum corneum of the skin to more efficiently deliver the desired drug.

1 shows a prior art applicator (hereinafter referred to as a "microneedle patch applicator") for applying a microneedle-formed patch to the skin. The microneedle patch applicator shown in FIG. 1 is disclosed by US2008 / 0009811A1 of 3M Innovative Properties Company.

First, the microneedle patch is prepared as shown in the left figure.

This circular patch is a circular patch is disposed on the pillar portion 34, as shown in the center figure, the pillar portion 34 in the left to right direction in the separated state of the pillar portion 34 that can be removed from the applicator body As it is inserted into the locking step 50 is indicated by the reference numeral 50 in the picture on the right. In this state, when the pillar portion 34 is assembled to the applicator, the microneedle patch applicator is ready for use.

Although the elastic force of the spring 44 presses the piston 42 to the right in the state of the middle figure, the switch 36 connected to the piston 42 prevents the advance of the piston 42 in the locking position. At this time, when the user releases the lock by pressing the switch 36 downward, as shown in the right figure, the piston 42 moves forward by the elastic force of the spring 44 and catches the microneedle patch 50. Pushed away from the body and pressed into the skin of the user. The microneedle formed on the microneedle patch is penetrated into the skin of the user by the uniform pressing force by the elastic force of the spring 44, and the penetration state of the microneedle into the skin is that the adhesive face 24 formed on the patch is applied to the microneedle patch. It can be retained by attaching to it.

If the drug must be delivered through the microneedle into the body, the microneedle patch needs to adhere to the skin at a uniform pressure over time.

However, in the prior art as described above, once the microneedle patch is attached to the user's skin by the applicator, the maintenance of adhesion depends only on the adhesive having only limited adhesive force formed on the patch itself. Some microneedles that penetrate the skin may escape. In this case, the desired drug delivery amount is not achieved, and the medicinal effect to be achieved by absorption of the drug may not be achieved.

2 conceptually illustrates this phenomenon.

The left figure of FIG. 2 shows the penetration of the ideal microneedle into the skin. Drugs formed as microneedles are intended to be applied to the user's skin for a period of time in the infiltrating state as shown in the left figure of FIG. However, if the microneedle of the microneedle patch is partially detached from the user's skin due to the decrease in adhesive force or external force during application of the user's skin of the microneedle patch, and reaches the infiltration state as shown in the right figure of FIG. Even after elapse of time, the amount of drug absorbed into the user's body during the time may be less than when the state shown in the left figure of FIG. 2 is maintained, which may lead to failure of achieving a desirable medicinal effect.

Furthermore, in the prior art as shown in FIG. 1, the microneedle patch inserted into the applicator is made of a flexible material for close contact with the user's skin, and for this reason, the microneedle patch can be easily bent during insertion into the applicator. It was difficult to insert into the exact position and position desired, and the microneedle was frequently damaged during the insertion process.

The present invention is to solve the above-mentioned problems of the prior art, and aims to:

First, it is an object of the present invention to provide a microneedle patch applicator that can stably maintain an optimal skin penetration state for a desired time while a microneedle patch is applied to a user's skin.

Second, an object of the present invention is to provide a microneedle patch applicator capable of maximally suppressing contamination and damage of the microneedle in the process of mounting the microneedle patch on the applicator.

The microneedle patch applicator 20 according to the present invention includes a main body 21, a band 30 attached to the main body 21 to connect the main body 21 to a user's body, and the main body 21 of the main body 21. Slot 22 formed on the side, and the cylinder 23 for pressing down the microneedle patch 10 inserted into the slot 22.

The microneedle patch 10 is attached to the insertion support 11 via a coupling point formed at its outer circumference, so that the insertion support 11 surrounds the microneedle patch 10 in a bonded state. In addition, the microneedle patch 10 is inserted into the slot 22 while being attached to the insertion support 11, and when the microneedle patch 10 is pressed downward by the cylinder 23, the bonding point is broken so that the microneedle patch ( 10) is pressed to the user's skin in a state in which the coupling with the insertion support 11 is released. The pressurized state is maintained until there is a separate release operation. The microneedle patch 10 is made of a flexible material that can be applied to the curved skin of the user, and the insertion support 11 is inserted into the slot 22 in a state in which the microneedle patch 10 is coupled. It is made of a material that can maintain shape for.

The microneedle patch applicator 20 according to the first embodiment of the present invention includes a cam switch 24 rotatably connected to the main body 21. As the cam switch 24 rotates, the cylinder 23 is pressed downward, and the cylinder 23 compresses the spring 25 while being pressed downward. When the cam switch 24 is returned to its original position, the cylinder 23 is raised to its original position by the pressure of the spring 25.

In the microneedle patch applicator 20 according to the second embodiment of the present invention, the upper end of the cylinder 23 is exposed to the outside of the main body 21 so that the user can apply downward pressing force. The cylinder 23 has a locking portion 26 is formed. The cylinder 23 is fixed to the locking portion 26 by the inner structure of the main body 21 while compressing the spring 25 when the downward pressure. The main body 21 is provided with a button 27 that can release the locking portion 26 from the internal structure of the main body 21. When the button 27 is operated, the cylinder 23 is raised to its original position by the pressure of the spring 25.

In the microneedle patch applicator 20 according to the third embodiment of the present invention, the main body 21 includes an upper housing 21-1 and a lower housing 21-2. The upper housing 21-1 is coupled to the lower housing 21-2 in a state capable of vertically moving and rotating with respect to the lower housing 21-2. As the user presses the upper housing 21-1 downward, the upper housing 21-1 presses downward and presses the cylinder 23 downward. When the spring 25 is compressed when the upper housing 21-1 is pressed downward, the engaging portion 28 formed in the upper housing 21-1 is caught and fixed to the inner structure of the lower housing 21-2. As the upper housing 21-1 is rotated with respect to the lower housing 21-2, the locking portion 28 of the upper housing 21-1 detaches from the internal structure of the lower housing 21-2. The fixing is released and the upper housing 21-1 and the cylinder 23 are raised to their original positions by the pressure of the spring 25.

According to the present invention, a microneedle patch applicator may be provided to stably maintain an optimal skin penetration state for a desired time while the microneedle patch is applied to a user's skin.

Further, according to the present invention, a microneedle patch applicator capable of maximally suppressing contamination and damage of the microneedle patch in the process of mounting the microneedle patch on the applicator may be provided. In addition, user convenience may also be increased in the process of mounting the microneedle patch on the applicator.

1 illustrates a prior art microneedle patch applicator.

2 is a conceptual diagram contrasting a preferred intradermal penetration state and a non-dermal state of the microneedle patch.

3 is a view showing the overall appearance of a microneedle patch applicator according to a first embodiment of the present invention.

4 is a diagram illustrating a microneedle patch applicator and a microneedle patch applied thereto according to a first embodiment of the present invention.

FIG. 5 is a view illustrating a microneedle patch inserted into a slot of a microneedle patch applicator according to a first embodiment of the present invention.

FIG. 6 is a view illustrating a state in which the cam switch is rotated in a downward pressure state of a cylinder while a microneedle patch is inserted into a slot of a microneedle patch applicator according to a first embodiment of the present invention.

FIG. 7 is a view illustrating the state of FIG. 6 viewed from below. FIG.

8 is a diagram illustrating an internal structure of a microneedle patch applicator according to a first embodiment of the present invention.

9 is a view showing the overall appearance of a microneedle patch applicator according to a second embodiment of the present invention.

10 is a view showing the internal structure of a microneedle patch applicator according to a second embodiment of the present invention.

Fig. 11 is a view showing the overall appearance of a microneedle patch applicator according to a third embodiment of the present invention.

12 is a view showing the internal structure of a microneedle patch applicator according to a third embodiment of the present invention.

10: microneedle patch

11: insertion support

20: Microneedle Patch Applicator

21: main body

21-1: Upper housing

21-2: Lower housing

22: slot

23: cylinder

24: cam switch

25: spring

26: engaging portion

27: button

28: catch

30: band

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings so that the present invention may be easily implemented by those skilled in the art.

In order to clearly describe the present invention, parts irrelevant to the present invention are omitted, and like reference numerals designate like elements throughout the specification. In addition, the size and the like of each configuration shown in the drawings are arbitrarily shown for convenience of description, the present invention is not necessarily limited to the illustrated.

That is, the specific shapes, structures, and characteristics described in the specification may be embodied by changing from one embodiment to another without departing from the spirit and scope of the present invention. It is to be understood that changes may be made without departing from the scope. Accordingly, the following detailed description is not to be taken in a limiting sense, and the scope of the present invention should be taken as encompassing the scope of the claims of the claims and all equivalents thereto.

In the microneedle patch applicator 20 shown in FIG. 3, as shown, a band 50 is connected to the main body 21. The band 50 is provided for fixing the microneedle patch applicator 20 to the user's body, the length can be adjusted according to the position to be attached in the user's body. When the microneedle patch applicator 20 is applied to the user's arm, the length of the band 50 can be adjusted relatively short, and when the applicator 20 is applied to the user's abdomen, the length of the band 50 is relatively It can be adjusted long.

Because the band 50 is connected to the body 21 of the microneedle patch applicator 20 and the band 50 keeps the body 21 of the microneedle patch applicator 20 attached to the user's body, the microneedle patch Even after the adhesive is attached to the user's skin, the pressure to the skin may be maintained at a uniform pressure.

Therefore, the problem that the microneedle of the microneedle patch is separated from the user's skin by external force or the adhesive force of the adhesive applied to the patch during application of the user's skin of the microneedle patch can be solved. It can be controlled so that the desired medicinal effect can be achieved well.

However, in order to continue to pressurize the skin at a uniform pressure even after the microneedle patch is attached to the user's skin, only the presence of the band 50 is insufficient. Technical means for pressing the microneedle patch 10 into the skin from the microneedle patch applicator 20 is necessary to maintain the pressurization for a certain time. Technical means for pressing and sustaining the microneedle patch 10 into the skin of the user in the microneedle patch applicator 20 are described below.

The slot 22 is provided on the side of the main body 21 of FIG. 3. The function of the slot 22 will be described in more detail with reference to FIG. 4.

In order to understand exactly the function of the slot 22 provided on the side of the main body 21 of the microneedle patch applicator 20 according to the present invention, the structure of the microneedle patch 10 provided in the slot 22 is described. Understanding must be preceded.

In the present invention, the microneedle patch 10 is not inserted into the slot 22 provided on the side of the main body 21 of the microneedle patch applicator 20 in the final form applied to the user's skin.

As shown in FIG. 4, the microneedle patch 10 is inserted into the slot 22 while attached to the insertion support 11. The insertion support 11 and the microneedle patch 10 are coupled in a state where the microneedle patch 10 can be easily separated from the insertion support 11 when downward pressing force is provided to the patch portion by the operation of the applicator in the future. It is. In the embodiment of Fig. 4, the bonding is maintained by a total of three bonding points, which are broken down when the microneedle patch 10 is applied to the user's skin in the future.

The material of the insertion support 11 is not particularly limited, but as shown in FIG. 4, the shape of the insertion support 11 is maintained in a state in which the microneedle patch 10 is coupled so that there is no problem of being inserted into the slot 22 having a predetermined shape. The stiffness to the extent possible should be retained.

As such, the microneedle patch 10 is not applied to the applicator in a final shape that is applied to the user's skin, that is, a shape that is flexible enough to be applied smoothly to the curved skin, and is not applied to the applicator body 21 of the applicator. Since it is applied to the applicator in a state coupled to the insertion support 11 to be easily inserted into the slot 22 formed on the side, not only contamination and damage of the microneedle in the application process to the applicator can be prevented as much as possible, User convenience can also be increased.

The above-mentioned effects, i) the effect of preventing the microneedle from contamination and damage as much as possible in the application process of the microneedle patch to the applicator and ii) the effect of increasing the user convenience are unique to the slot structure and insertion support peculiar to the present invention. It is to be understood that this is achieved by means of a structure that allows the patch to be inserted into the slot in a coupled state.

4 shows a cam switch 24 which produces the characteristic downward pressing force of the first embodiment of the present invention. The function of the cam switch 24 will be described in more detail with reference to FIGS. 5 and 6.

FIG. 5 is a view illustrating a microneedle patch inserted into a slot of the microneedle patch applicator 20 according to the first embodiment of the present invention.

FIG. 6 is a view showing the cam switch 24 being rotated in a cylinder downward pressure state with the microneedle patch inserted into the slot 21 of the microneedle patch applicator 20 according to the first embodiment of the present invention. Drawing.

5 and 6, the state before the downward pressurization of the microneedle patch 10 is illustrated in FIG. 5, and the state of the downward pressurization of the microneedle patch 10 is illustrated in FIG. 6. That is, in the embodiment shown in Figs. 5 and 6, the cam switch 24 is in a state in which the vertical position as shown in Fig. 5 is before the downward pressurization, that is, the cylinder 23 whose upper surface is shown in Fig. 5. ) Before pressing down. In this state, the cam surface of the cam switch 24 has a minimum thickness.

When the cam switch 24 is laid horizontally as shown in FIG. 6, the cam surface is changed according to the rotation of the cam switch 24 so that the cam surface having the maximum thickness contacts the cylinder 23. As a result, the cylinder 23 is pressed downward. The microneedle patch 10 inserted into the slot 22 according to the downward pressure of the cylinder 23 is separated from the insertion support 11 and applied to the skin of the user. The state in which the cylinder 23 is pressed downward and the microneedle patch 10 is applied to the user's skin will be described in more detail with reference to FIG. 7.

FIG. 7 is a view illustrating the state of FIG. 6 viewed from below. FIG.

The upper surface of the cylinder 23 is formed in a wide rectangle to easily accommodate the cam operation by the rotation of the cam switch 24 as shown in Figure 5, the lower surface of the microneedle to press the user's skin It is preferable to have a shape corresponding to the shape of the patch 10. The lower surface of the body 21 of the microneedle patch applicator 20 corresponds to the shape of the lower surface of the cylinder 23 as described above.

When the cam switch 24 is operated in the first embodiment of the present invention, the cylinder 23 moves downward by receiving the change of the cam surface, and thus the cylinder 23 having a shape corresponding to the microneedle patch 10. The lower surface of the microneedle patch 10 is pressed downward, so that the microneedle patch 10 is inserted into the slot 21 to be separated from the insertion support 11 which is restricted downward movement and is applied to the user's skin. 7 clearly shows a state in which the microneedle patch 10 is separated from the insertion support 11 and applied to the user's skin.

Referring to FIG. 8, it can be seen that a spring 25 is provided between the upper surface of the cylinder 23 and the main body. This spring 25 is compressed when the cylinder 23 moves downward by the rotational operation of the cam switch 24 and is spaced between the cam surface and the upper surface of the cylinder 23 when the cam switch 24 returns to its original position. The upper surface of the cylinder 23 is pressed upward so that the cylinder 23 does not exist, and the cylinder 23 is returned to its original position. Interaction relationship between the cam switch 24, the cylinder 23, the microneedle patch 10 according to the first embodiment of the present invention described with reference to Figures 3 to 7 with reference to the internal structure shown in FIG. It will be more clearly understood.

The first embodiment of the present invention has been described above with reference to FIGS. 3 to 8. Although the cylinder 23 is described as being pressurized downward when the cam switch 24 is changed from the upright position to the horizontally laid down state, the operation can be reversed as much as the cam surface is changed. It should be understood. That is, the first embodiment of the present invention may be implemented such that the cylinder 23 is pressurized downward when the cam switch 24 is changed from the horizontally laid down state to the vertically held state without departing from the scope of the present invention. .

In the second embodiment of the present invention shown in FIG. 9, the upper end of the cylinder 23 is exposed to the outside of the main body 21 so that the user can apply downward pressing force. In the state shown in FIG. 9, the cylinder 23 exposed to the outside of the main body 21 is pressed downward by the user. The microneedle patch inserted into the slot 22 by the downward pressure of the cylinder 23 is applied to the skin of the user. In the present invention, it is necessary to maintain the state after the cylinder 23 is pressed downward, that is, the state applied to the skin of the user for a certain time. Technical means for this can be understood in detail from FIG.

As shown in FIG. 10, the engaging portion 26 is formed in the cylinder 23. Although not shown in FIG. 10, a spring is located between the cylinder 23 and the body 21. Therefore, the spring is compressed when the cylinder 23 is pressed downward. At the same time, the engaging portion 26 formed in the cylinder 23 is caught and fixed to the internal structure of the main body. As a result, the cylinder 23 is pressed downward to maintain the state in which the microneedle patch is pressed against the skin of the user (not shown in FIG. 10). This state corresponds to the right figure of FIG.

On the other hand, the main body 21 of the microneedle patch applicator 20 is provided with a button 27 to release the fixing from the internal structure of the main body 21 of the locking portion 26 to the main body 21. When the button 27 is pressed into the main body in the state as shown in the right figure of FIG. 10, that is, the downward pressure of the cylinder 23 is maintained, the locking portion 26 moves inward to the inner structure of the main body 21. The fixed state is released, and at this time, the spring presses the cylinder 23 upwards so that the cylinder 23 rises to its original state. Since the pressurization of the microneedle patch 10 to the user's skin is released as the cylinder 23 rises to its original state, the operation of the button 27 needs to press the microneedle patch 10 to the user's skin. It is done when there is no state.

In the third embodiment of the present invention shown in FIG. 11, the main body 21 includes an upper housing 21-1 and a lower housing 21-2. The upper housing 21-1 is coupled to the lower housing 21-2 in a state capable of vertically moving and rotating with respect to the lower housing 21-2. In the state shown in FIG. 11, the upper housing 21-1 is not pressed downward with respect to the lower housing 21-2, and therefore, before the microneedle patch inserted in the slot 22 is applied to the user's skin. to be. The manner in which the upper housing 21-1 is pressed downward with respect to the lower housing 21-2, and the method of applying the microneedle patch to the skin of the user and maintaining the downward pressure state will be described with reference to FIG. 12.

Although not shown in FIG. 12, when the upper housing 21-1 is pressed downward, the spring is compressed to accumulate a force for pressing the upper housing 21-1 upward. In addition, the upper housing 21-1 and the cylinder 23 are operatively connected in the up-down direction, as shown in FIG. That is, the cylinder 23 moves downward together when the upper housing 21-1 moves downward, and the cylinder 23 moves upward together when the upper housing 21-1 moves upward.

When the upper housing 21-1 is pressed downward, the internal structure of the lower housing 21-2 has a locking portion 28 formed in the upper housing 21-1 while the spring is compressed as described above. The part marked with #).

On the other hand, a characteristic part of this third embodiment is that the upper housing 21-1 is rotatable with respect to the lower housing 21-2, and the above-mentioned fixing is released by this rotation. In the embodiment shown in FIG. 12, when the upper housing 21-1 rotates clockwise with respect to the lower housing 21-2, the engaging portion 28 of the upper housing 21-1 is lowered in the lower housing 21. The fixing is released from the internal structure of -2), and the upper housing 21-1 and the cylinder 23 are raised to their original positions by the upward pressing force provided by the spring.

Claims

With the body 21,

A band 30 attached to the main body 21 and connecting the main body 21 to a user's body;

Slot 22 formed on the side of the main body 21,

It includes a cylinder 23 for pressing down the microneedle patch 10 inserted into the slot 22,

The microneedle patch 10 is attached to the insertion support 11 via a coupling point formed at its outer circumference, so that the insertion support 11 surrounds the microneedle patch 10 in a coupled state.

The microneedle patch 10 is inserted into the slot 22 while attached to the insertion support 11,

When the pressure is downwardly pressed by the cylinder 23, the bonding point is broken so that the microneedle patch 10 is pressed against the user's skin in a state in which the coupling with the insertion support 11 is released.

The pressurized state is maintained until there is a separate release operation,

The microneedle patch 10 is made of a flexible material that can be applied to the curved skin of the user,

The insertion support 11 is made of a material capable of maintaining a shape for insertion into the slot 22 in a state in which the microneedle patch 10 is coupled,

Microneedle Patch Applicator 20.
The method of claim 1,

A cam switch 24 connected to the main body 21 and rotatable;

The cylinder 23 is pressed downward in accordance with the rotation of the cam switch 24,

The cylinder 23 compresses the spring 25 while pressing downward,

When the cam switch 24 is returned to its original position, the cylinder 23 is raised to its original position by the pressure of the spring 25.

Microneedle Patch Applicator 20.
The method of claim 1,

The upper end of the cylinder 23 is exposed to the outside of the main body 21 so that the user can apply a downward pressing force,

The cylinder 23 has a locking portion 26 is formed,

When the cylinder 23 is pressed downward, the locking portion 26 is fixed to the inner structure of the main body 21 while compressing the spring 25.

The main body 21 is provided with a button 27 that can release the locking portion 26 from the internal structure of the main body 21,

When the button 27 is operated, the cylinder 23 is raised to its original position by the spring 25 pressure.

Microneedle Patch Applicator 20.
The method of claim 1,

The main body 21 includes an upper housing 21-1 and a lower housing 21-2,

The upper housing 21-1 is coupled to the lower housing 21-2 in a state capable of vertically moving and rotating with respect to the lower housing 21-2.

As the user presses the upper housing 21-1 downward, the upper housing 21-1 presses downward and presses the cylinder 23 downward,

When the spring 25 is compressed when the upper housing 21-1 is pressed downward, the engaging portion 28 formed on the upper housing 21-1 is fixed to the inner structure of the lower housing 21-2.

As the upper housing 21-1 is rotated with respect to the lower housing 21-2, the locking portion 28 of the upper housing 21-1 detaches from the internal structure of the lower housing 21-2. The fixing is released and the upper housing 21-1 and the cylinder 23 are raised to their original positions by the pressure of the spring 25,

Microneedle Patch Applicator 20.