WO2013093931A3 - Novel prodrugs of phenolic drugs - Google Patents

Novel prodrugs of phenolic drugs Download PDF

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Publication number
WO2013093931A3
WO2013093931A3 PCT/IN2012/000590 IN2012000590W WO2013093931A3 WO 2013093931 A3 WO2013093931 A3 WO 2013093931A3 IN 2012000590 W IN2012000590 W IN 2012000590W WO 2013093931 A3 WO2013093931 A3 WO 2013093931A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel prodrugs
phenolic drugs
phenolic
drugs
novel
Prior art date
Application number
PCT/IN2012/000590
Other languages
French (fr)
Other versions
WO2013093931A2 (en
Inventor
Jiten Ranchhodbhai Patel
Gopalkumar Chimanlal Patel
Gaurav Sanjivkumar Sheth
Sanjay Nandlalji MANDHANE
Trinadha Rao Chitturi
Rajamannar Thennati
Original Assignee
Sun Pharma Advanced Research Company Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharma Advanced Research Company Ltd. filed Critical Sun Pharma Advanced Research Company Ltd.
Publication of WO2013093931A2 publication Critical patent/WO2013093931A2/en
Publication of WO2013093931A3 publication Critical patent/WO2013093931A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to novel hydrazide group containing carbamate prodrugs of phenolic drugs of formula (I) or pharmaceutically acceptable salt thereof, and process for the preparation thereof.
PCT/IN2012/000590 2011-09-19 2012-09-06 Novel prodrugs of phenolic drugs WO2013093931A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2647/MUM/2011 2011-09-19
IN2647MU2011 2011-09-19

Publications (2)

Publication Number Publication Date
WO2013093931A2 WO2013093931A2 (en) 2013-06-27
WO2013093931A3 true WO2013093931A3 (en) 2013-08-08

Family

ID=48050873

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000590 WO2013093931A2 (en) 2011-09-19 2012-09-06 Novel prodrugs of phenolic drugs

Country Status (1)

Country Link
WO (1) WO2013093931A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015099863A1 (en) * 2013-12-27 2015-07-02 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
CN104262352B (en) * 2014-09-01 2018-06-15 中国人民解放军军事医学科学院毒物药物研究所 Camptothecin derivative and its medical usage
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods
US11478490B1 (en) 2021-03-30 2022-10-25 Epalex Corporation Fospropofol formulations
US11439653B1 (en) 2021-03-30 2022-09-13 Epalex Corporation Fospropofol formulations
US11628178B2 (en) 2019-03-26 2023-04-18 Epalex Corporation Fospropofol methods and compositions
US11547714B2 (en) 2020-02-05 2023-01-10 Epalex Corporation Fospropofol salts, methods and compositions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604463A (en) * 1983-07-14 1986-08-05 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US20090005352A1 (en) * 2004-07-12 2009-01-01 Xenoport, Inc. Prodrugs of Propofol, Compositions and Uses Thereof
WO2010112942A1 (en) * 2009-04-02 2010-10-07 Shire Llc Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7230A (en) 1850-04-02 Machine for hoisting
US4551452A (en) 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
AU5108596A (en) 1995-03-14 1996-10-02 Mundipharma Gmbh Morphine-3-esters
US6225321B1 (en) 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
BRPI0712819B8 (en) 2006-05-26 2021-05-25 Pharmacofore Inc compound for controlled release of phenolic opioids, process for the preparation of said compound and pharmaceutical composition
US7511054B2 (en) 2006-09-22 2009-03-31 Alltranz Inc. Transdermally deliverable opioid prodrugs, abuse-resistant compositions and methods of using opioid prodrugs
US20090192095A1 (en) 2008-01-18 2009-07-30 Shire Llc Amino acid and peptide prodrugs of opioid analgesics with reduced gi side-effects

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604463A (en) * 1983-07-14 1986-08-05 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US20090005352A1 (en) * 2004-07-12 2009-01-01 Xenoport, Inc. Prodrugs of Propofol, Compositions and Uses Thereof
WO2010112942A1 (en) * 2009-04-02 2010-10-07 Shire Llc Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. YOON, ET AL.: "Solution and soluble polymer synthesis of 3-aminoimidazoline-2,4-diones", CHEMICAL COMMUNICATIONS, no. 24, December 1998 (1998-12-01), Royal Society of Chemistry, Cambridge, GB, pages 2703 - 2704, XP002162268, ISSN: 0022-4936, DOI: 10.1039/a807067i *
M. SABURI, ET AL.: "Stereochemical studies of metal chelates. VII. The preparation, stereochemistry and circular dichloism of dinitrocobalt(III) complexes with (3S, 8S)-dimethyltriethylenetetramine and related tetramines", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 45, no. 4, 1972, pages 1086 - 1093, XP055067195, ISSN: 0009-2673, DOI: 10.1246/bcsj.45.1086 *
W. ELGER, ET AL.: "Sulfamates of various estrogens are prodrugs with increased systemic and reduced hepatic estrogenicity at oral application", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY., vol. 55, no. 3-4, December 1995 (1995-12-01), Elsevier Science, Oxford, GB, pages 395 - 403, XP005348960, ISSN: 0960-0760, DOI: 10.1016/0960-0760(95)00214-6 *

Also Published As

Publication number Publication date
WO2013093931A2 (en) 2013-06-27

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