WO2012046199A1 - Surveillance de dosage de liquide - Google Patents

Surveillance de dosage de liquide Download PDF

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Publication number
WO2012046199A1
WO2012046199A1 PCT/IB2011/054392 IB2011054392W WO2012046199A1 WO 2012046199 A1 WO2012046199 A1 WO 2012046199A1 IB 2011054392 W IB2011054392 W IB 2011054392W WO 2012046199 A1 WO2012046199 A1 WO 2012046199A1
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WO
WIPO (PCT)
Prior art keywords
dosage
monitoring device
dosage monitoring
liquid dispenser
memory
Prior art date
Application number
PCT/IB2011/054392
Other languages
English (en)
Inventor
Hendrik Meiring
Original Assignee
Hendrik Meiring
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hendrik Meiring filed Critical Hendrik Meiring
Publication of WO2012046199A1 publication Critical patent/WO2012046199A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/332—Force measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3584—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using modem, internet or bluetooth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6036—General characteristics of the apparatus with identification means characterised by physical shape, e.g. array of activating switches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31546—Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons

Definitions

  • This invention relates monitoring the dispensing of liquids.
  • the invention relates to monitoring doses of liquids injected into mammalian subjects.
  • Various devices are available for dispensing multiple doses of liquids to subjects and these devices typically include means for setting the quantity of the liquid to be dispensed in a single dose and means for dispensing the liquid.
  • a typical example is an injection device for subcutaneous injection of insulin, in which successive doses of insulin are dispensed from a reservoir and are injected into the subject. The user can typically adjust the quantity of each dose.
  • Insulin (like many other liquids) needs to be dispensed regularly in order to maintain desired levels of insulin in the subject's body and accordingly, it is essential that subsequent dosages are administered, taking into account the quantities and time of recent dosages. Individual dosages are often administered at predetermined intervals during an otherwise normal life of the subject and circumstances often make accurate record-keeping difficult, so that insulin is administered, based on the subject's recollection of recent dosages. The subject's recollection is obviously prone to inaccuracy with a resulting risk of administering incorrect dosages. Insulin is typically supplied in multi-dose dispensers, referred to as "pens", which are either disposable or which are re-usable and can be loaded with cartridges of insulin. Attempts have been made to record the quantities and time of dosages with re- usable insulin pens, as described in US Patent Application No. 12/442,168
  • the record keeping apparatus in these pens is costly and accordingly, it has not been applied to disposable insulin pens.
  • the present invention seeks to provide means for keeping record of the quantities and times of liquid dosages dispensed to subjects, in a manner that is cost effective and that can preferably be used in conjunction with different commercially available dispensing apparatus.
  • a dosage monitoring device for use in conjunction with a liquid dispenser, said dosage monitoring device
  • a quantity sensor configured to determine the quantity of an individual dosage, when dispensed from the liquid dispenser and to record said quantity in the memory
  • a dispensing sensor configured to sense when said individual dosage is
  • feedback means configured to make the quantity of said individual dosage available for display
  • said dosage monitoring device is releasably attachable to said liquid dispenser.
  • the dosage monitoring device may include a clock and the dispensing sensor may be configured to record the time of the event of dispensing said dosage, according to the clock, in the memory.
  • the feedback means may be configured to make the time of said individual dosage available for display.
  • the dosage monitoring device may be configured to receive input in the form of a set dosage, to store said set dosage in the memory and the feedback means may be configured to make said set dosage available for display.
  • the feedback means may include a display on the dosage monitoring device, on which the quantity and/or time of said individual dosage, and/or said set dose is displayed and/or the feedback means may include means for transmitting a signal containing said data of each individual dosage to a remote device, external to the dosage monitoring device.
  • the liquid dispenser may include a rotatable dose setting element (e.g. a helically moving scale drum) and the quantity sensor of the dosage monitoring device may include means for determining the rotation of the dose setting element.
  • the liquid dispenser may include a linearly displaceable dosing element such as a push button or the like and the dosage monitoring device may include means for determining the linear displacement of the dosing element.
  • the dosage monitoring device may include a click mechanism, configured to emit a sound upon incremental changes in the quantity of the dosage.
  • the dosage monitoring device may include a switch such as a button and may be configured to dispense a set quantity of said liquid, when said button is pressed.
  • the liquid dispenser may be actuated to dispense said liquid using stored energy, upon pressing the button of the dosage monitoring device.
  • the dosage monitoring device may include at least one sensor that is configured to identify a feature of a liquid dispenser to which the device is attached, in order to identify the liquid dispenser.
  • Figure 1 is a side elevation of a liquid dispenser in the form of a typical disposable insulin pen in accordance with the prior art
  • Figure 2 is a detail end view of a helical dial of the insulin pen of Figure 1 ;
  • Figure 3A is a side elevation of a dose setting mechanism of the insulin pen of Figure 1 ;
  • Figures 3B to 3D are sectional views of the dose setting mechanism of Figure 3A in different dose setting positions;
  • Figure 3E is an end view of the dose setting mechanism of Figure 3A;
  • FIG. 4 is a schematic diagram of a dosage monitoring device in accordance with the present invention.
  • Figure 5 is a three dimensional view of an end of the insulin pen of Figure 1 , with its push button removed;
  • Figure 6 is an end view of the end of the insulin pen of Figure 5;
  • Figure 7 is a three-dimensional view of a dosage monitoring device in accordance with a first embodiment of the present invention.
  • Figure 8 is an end view of the dosage monitoring device of Figure 7.
  • Figure 9 is three-dimensional view of parts of a dosage monitoring device in
  • a disposable insulin pen in accordance with the prior art is described and is generally identified by reference numeral 10.
  • the present invention relates to a dosage monitoring device that is intended to be used in conjunction with a liquid dispensing device and a disposable insulin pen is merely an example of such a liquid dispensing device.
  • the pen 10 includes three detachable parts, being a pen body 12, a cap 14 and a needle (not shown) that screws onto an end of the pen body and seals against a rubber membrane 16.
  • the body 12 can conveniently be described as housing an insulin cartridge 18 and a dosing mechanism 20.
  • the insulin cartridge serves as a reservoir of insulin to be dispensed through the needle and includes an internal dispensing mechanism that is actuated by rotation.
  • the dosing mechanism includes a rotatable dosage selector 22, a dosing element in the form of a push button 24 and dose indicator 26.
  • a dose setting mechanism 28 which forms part of the dosing mechanism 20.
  • the dose setting mechanism 28 includes a hollow, cylindrical rear part 30 of the pen body 12, with the dosage selector 22 at its one end and a key 32 protruding from its opposite end.
  • the dosage selector 20 is integrally formed with a hollow, cylindrical outer dosage dial 34 that extends inside the body 30, with a helical ridge-and-groove engagement which allows the dial to be displaced helically relative to the body, when the dosage selector is rotated.
  • the clockwise and counter-clockwise rotation thus slides the outer dosage dial 34 in and out of the body 30 and this is done in set increments, which are displayed on the dose indicator 26, which is merely a window in the body's wall, through which a calibration on the outer dosage dial 34 is visible.
  • the key 32 has a rectangular profile at an end that engages the insulin cartridge 18, so that when the key 32 is rotated, it drives a plunger of the internal dispensing mechanism inside the insulin cartridge 18, which dispenses insulin through the needle.
  • the quantity of insulin dispensed is directly proportional to the rotation of the key 32 (and the plunger) and the key and plunger can only rotate counter- clockwise.
  • a dosage stop ring 36 is provided inside the outer dosage dial 34 and around a cylindrical extension of the key 32 and the stop ring is configured to interact with inward ridge of the outer dosage dial, to prevent the dosage dial from being displaced out of the body 30 beyond a certain position, which corresponds to a maximum insulin dosage - as will be described below.
  • the body 30, key 32 and stop ring 36 are not displaceable relative to each other in an axial direction.
  • the key 32 is rotatable relative to the body 30 in the clockwise direction only and the dosage selector 22 and outer dosage dial 34 are displaceable axially relative to the body 30 and can be rotated in both directions.
  • An inner dosage dial 38 extends inside the outer dosage dial 34, with an annular space between the dosage dials 34,38 and the inner dosage dial 38 interacts helically with the stop ring 36 and includes a protuberance that extends into a longitudinal grove in the key 32.
  • the inner dosage dial 38 has an external shoulder inside the dosage selector 22, which is held in position inside the selector 22 by the push button 24 (which is not shown in Figures 3A to 3E).
  • the shoulder 40 allows the inner and outer dosage dials 38,34 to move together in the axial direction and to rotate relative to each other.
  • the engagement of the inner dosage dial 38 with the longitudinal groove in the key 32 ensures that the inner dosage dial 38 and key 32 always rotate together (only in the clockwise direction, as mentioned above), but the inner dosage dial 38 can slide axially relative to the key 32, when the outer dosage dial 34 is rotated and slides in and out of the body 30.
  • a user rotates the dosage selector 22 clockwise to increase the dosage and if necessary, counter-clockwise to reduce the dosage.
  • This rotation does not dispense insulin yet, but causes the outer and inner dosage dials 34,38 to slide axially out of the body 30 (and partly inwards again, if rotated counter-clockwise) and to show a dosage corresponding to the axial displacement, on the dose indicator 26.
  • the inner dosage dial 38 moves axially, but does not rotate relative to the body 30 and the key 30 remains stationary relative to the body 30.
  • the button 24 When the user is satisfied with the insulin dosage selected by rotation of the dosage selector 22, he pushes the button 24 in an axial direction and the initial axial movement of the button causes the inner and outer dosage dials 38,34 to be locked against rotation relative to each other. The user then continues to push the button 24 axially towards the body 30, which urges both the inner and outer dosage dials 38,34 to slide into the body 30 and at the same time, the helical engagement between the outer dial 34 and the body 30, causes both dosage dials 34,38 to rotate counter-clockwise.
  • the counter-clockwise rotation of the inner dosage dial 28 causes the key 32 to rotate counter-clockwise and thus causes insulin to be dispensed from the cartridge 18 and to be injected subcutaneously into a subject, such as a human.
  • the clockwise rotation of the dosage selector 22, the axial displacement of the dosage dials 34,38, the helical rotation of the dosage dials and of the key 32, are all directly proportional to the quantity of insulin that is dispensed. This proportionality explains why limiting axial displacement of the outer dosage dial 34 with the dosage stop ring 36, prevents a predetermined maximum dosage quantity from being exceeded.
  • FIGS 7 and 8 show an example of a dosage monitoring device in accordance with the present invention, which is generally indicated by reference numeral 46.
  • the device 46 is intended to be re-usable and is releasably attachable to the end of the insulin pen 10, by removing the push button 24 from the pen and partly inserting the device 46 into the hollow end of the dosage selector 22.
  • the device 46 can thus be removed from the pen 10 and can be re-used on another pen and it is thus suitable for use on disposable insulin pens.
  • the device 46 includes outwardly facing hook formations 48 and 50 that are configured to interact in ratchet-fashion with the castellated ridges 42 and ramped protuberances 44, respectively.
  • the device 46 houses electronic circuitry, represented by the diagram of Figure 4.
  • This circuitry includes a power source 52 providing electrical power to the system, a system controller 54, memory 56 for data storage, a display device 58 such as a display screen, a signal transmitter 60, host identification means 62 and dosage monitoring means 66.
  • the device 46 monitors the quantity of each dosage by measuring the actual dosage that is dispensed and/or by receiving a set quantity through user input or pre-programmed input. If the actual dosage quantity needs to be monitored, this can be done by implementing a wide variety of technology options or combinations and these include: optical measurement using LEDs, relying on either reflection or interruption; magnetic speed measurement; strain gauge measurement; mechanical switching; capacitance measurement; inductive rotation measurement; or the like. A wide variety of measurements are possible and as described above, these can measure any one of a number of mechanical parameters in the dose setting mechanism 28, each of which is directly proportional to the selected dosage.
  • the device 46 can be set up to sense relative rotation between the outer dosage dial 34 and the inner dosage dial 38, by monitoring deflection of the hook formations 42,44. This monitoring can also be used to emit a sound with each deflection of the hook formations, which would serve as an audible aid to the user, indicating of each incremental rotation.
  • the dosage monitoring means 66 measures the quantity of each dosage and preferably also records the time (and date) of the dosage, using a clock (not shown).
  • the dosage quantity and time is stored in the memory 56, which could implement any suitable technology, e.g. flash memory, EEPROM, RAM, or the like.
  • the stored dosage-related data and/or other data (such as the type of host pen 10, a set dosage, insulin type, user name, etc.) stored in the memory 56 can be displayed on the display device 58, which could implement any suitable technology, e.g. OLED, LCD, TFT, ELD, bi-stable e-link, character display, or the like.
  • the device 46 is configured to transmit data stored on the memory 56 to a remote device via the transmitter 60, e.g. for diagnostic analysis. Suitable technologies for the transmission include: infrared; wireless options such as RF, Zigbee, Bluetooth, wifi, etc.; cable connection such as USB, firewire, Ethernet, etc.
  • the device 46 can identify the insulin pen 10 or "host" on which it is fitted, by sensing physical attributes of the pen through its host identification means 62, by receiving input from a user, or the like. This information could be used to identify the type of insulin being dispensed.
  • the power source 52 can be a battery, photovoltaic cell, or the like.
  • the system controller 54 needs to implement logic to integrate the functional features described above with one another and a microcontroller will be suitable for this purpose.
  • FIG. 9 parts of another embodiment of a dosage monitoring device are shown and are identified collectively by reference numeral 70
  • the monitoring device 70 shares many features with the device 46 described above with reference to Figures 4, 7 and 8.
  • the device 70 is intended to be used in conjunction with the insulin pen 10 of Figures 1 to 3, but it does not require removal of the push button 24 or modification of the dosage selector 22 and inner dosage dial 38 as shown in Figures 5 and 6. Instead, the device 70 is releaseably attached to the insulin pen 10, without any modification.
  • Figure 9 also shows part of the pen body 30, the outer dosage dial 34, and the dosage selector 22. These parts of the insulin pen are identified collectively by reference numeral 10 and are shown alongside the device 70.
  • the device 70 is slid onto the pen 10 from the dosage selector's 22 end and a monitor body 72 of the device is removably received on the outside of the pen body 30.
  • the engagement between the pen body 30 and monitor body 72 includes a compressible filler, inwardly protuberances, or the like, so that the monitor body fits on the pen body with some interference and does not move relative to the pen body, once installed, unless a relatively strong force is applied to remove the device 70 from the pen 10.
  • a dial monitor 74 of the device 70 is received on the outside of the dosage selector 22 with some interference and does not move relative to the dosage selector until the device 70 is eventually removed from the pen 10, for re-use.
  • a monitor slider 76 extends between the monitor body 72 and the dial monitor 74. All three these components are cylindrically shaped and the dial monitor is attached to the monitor slider with a radial groove and ridge, so that the dial monitor can rotate relative to the monitor slider, but these two parts cannot move relative to each other in an axial direction.
  • the monitor slider 76 is fitted inside the monitor body 72 with a longitudinal key and groove arrangement (or the like), so that the monitor slider and monitor body can slide longitudinally relative to each other, but cannot rotate relative to each other.
  • the monitor body 72 can follow all movements of the pen body 30 and the dial monitor can follow all movements of the outer dosage dial 34 and the dosage selector 22, during normal use of the pen 10.
  • the device 70 includes circuitry similar to that shown in the diagram of Figure 4, but instead of dosage monitoring means 66 that measures angular displacement of rotation, as in the case of the device 46, the monitoring means 66 of the device 70 measures relative linear displacement between the monitor body 72 and the monitor slider 76 in the longitudinal direction.
  • One of many sensors that can be used to measure this relative linear displacement is a capacitive sensor using patterned electrodes with different patterns on the monitor body 72 and monitor slider 76 and detecting capacitive coupling between the two electrodes to determine direction and distance of the linear displacement.
  • the device 70 can also measure relative angular displacement between the dial monitor 74 and the monitor slider 76, using any one of a wide variety of sensing techniques, as mentioned above.
  • the monitor body 72 defines windows 78, one of which is in register with the dosage indicator, to ensure that the calibration on the outer dosage dial 34, which shows the dosage increments, are visible.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif de surveillance de dosage (46, 70) pour utilisation conjointe avec un distributeur de liquide (10) qui comprend une mémoire (56), un détecteur de quantité (66) configuré pour déterminer la quantité d'une dose individuelle distribuée et enregistrer la quantité dans la mémoire, un capteur de distribution (66) configuré pour détecter à quel moment ladite dose individuelle est distribuée et pour enregistrer l'événement de distribution dans la mémoire, et des moyens de rétroaction (58, 60) qui sont configurés pour rendre la quantité de la dose individuelle disponible pour affichage. Le dispositif de surveillance de dosage (46, 70) peut être attaché de façon réversible au distributeur de liquide (10) et peut être réutilisé.
PCT/IB2011/054392 2010-10-05 2011-10-05 Surveillance de dosage de liquide WO2012046199A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA201007145 2010-10-05
ZA2010/07145 2010-10-05

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Cited By (48)

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WO2014180745A1 (fr) * 2013-05-07 2014-11-13 Sanofi-Aventis Deutschland Gmbh Dispositif accessoire destiné à être fixé à un dispositif d'injection
WO2015082303A1 (fr) * 2013-12-05 2015-06-11 Novo Nordisk A/S Boîtier pour un dispositif d'injection médical
EP3058970A1 (fr) * 2015-02-19 2016-08-24 Sanofi-Aventis Deutschland GmbH Dispositif de collecte de données destiné à être fixé à un dispositif d'injection
WO2017050781A1 (fr) * 2015-09-23 2017-03-30 Sanofi-Aventis Deutschland Gmbh Dispositif pour fixation à un dispositif d'injection
WO2017132577A1 (fr) * 2016-01-29 2017-08-03 Companion Medical, Inc. Suivi automatique d'administration de médicament
EP3188061A3 (fr) * 2015-12-29 2017-11-01 InsuLog Ltd. Dispositif auxiliaire et système pour un injecteur permettant de surveiller des quantités injectées
CN107660156A (zh) * 2015-06-01 2018-02-02 诺和诺德股份有限公司 用于医疗注射装置的壳体
WO2018046680A1 (fr) * 2016-09-09 2018-03-15 Sanofi-Aventis Deutschland Gmbh Appareil de collecte de données destiné à être fixé sur un dispositif d'injection
WO2018104289A1 (fr) * 2016-12-07 2018-06-14 Sanofi Dispositif de collecte de données destiné à être fixé à un dispositif d'injection
EP3381494A1 (fr) * 2017-03-30 2018-10-03 Tecpharma Licensing AG Surveillance d'un processus d'injection
WO2019018791A1 (fr) * 2017-07-21 2019-01-24 Verily Life Sciences Llc Mesure de dosage basée sur une contrainte
WO2019046436A1 (fr) 2017-08-31 2019-03-07 Becton, Dickinson And Company Système et procédé permettant de détecter une force appliquée lors d'une injection
WO2019057911A1 (fr) * 2017-09-22 2019-03-28 Novo Nordisk A/S Dispositif accessoire pour dispositif d'administration de médicament
WO2019121448A1 (fr) * 2017-12-18 2019-06-27 Sanofi Capteur de rotation pour un dispositif d'injection
WO2019121617A1 (fr) * 2017-12-22 2019-06-27 Sanofi Dispositif d'administration de médicament
WO2019121452A1 (fr) * 2017-12-20 2019-06-27 Sanofi Dispositif pour fixation à un dispositif d'injection
WO2019129623A1 (fr) 2017-12-28 2019-07-04 Sanofi Appareil de collecte de données destiné à être fixé sur un dispositif d'injection
WO2019209491A1 (fr) * 2018-04-24 2019-10-31 Verily Life Sciences Llc Appareil de suivi de dose, système de suivi de dose et procédés d'utilisation associés
US10483000B2 (en) 2014-07-10 2019-11-19 Companion Medical, Inc. Medicine administering system including injection pen and companion device
US10704944B2 (en) 2014-09-14 2020-07-07 Becton, Dickinson And Company System and method for capturing dose information
USD892819S1 (en) 2018-06-20 2020-08-11 Companion Medical, Inc. Display screen with graphical user interface
USD893020S1 (en) 2018-05-11 2020-08-11 Companion Medical, Inc. Injection pen
WO2020225038A1 (fr) * 2019-05-03 2020-11-12 Sanofi Agencement de capture de rotation destiné à un dispositif d'injection
US20200368442A1 (en) * 2017-12-28 2020-11-26 Sanofi A sensor device for attachment to an injection device
US10874802B2 (en) 2015-06-09 2020-12-29 Sanofi-Aventis Deustschland Gmbh Data collection apparatus for attachment to an injection device
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