WO2008088030A1 - 血栓もしくは塞栓に関連する疾患の予防又は治療用組成物 - Google Patents

血栓もしくは塞栓に関連する疾患の予防又は治療用組成物 Download PDF

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Publication number
WO2008088030A1
WO2008088030A1 PCT/JP2008/050554 JP2008050554W WO2008088030A1 WO 2008088030 A1 WO2008088030 A1 WO 2008088030A1 JP 2008050554 W JP2008050554 W JP 2008050554W WO 2008088030 A1 WO2008088030 A1 WO 2008088030A1
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Prior art keywords
embolus
thrombus
prevention
treatment
composition
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PCT/JP2008/050554
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English (en)
French (fr)
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Hiroyuki Kawano
Ryo Saito
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Mochida Pharmaceutical Co., Ltd.
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Application filed by Mochida Pharmaceutical Co., Ltd. filed Critical Mochida Pharmaceutical Co., Ltd.
Priority to ES08703408.8T priority Critical patent/ES2524320T3/es
Priority to EP08703408.8A priority patent/EP2119443B1/en
Priority to CA2675836A priority patent/CA2675836C/en
Priority to JP2008554086A priority patent/JP5345402B2/ja
Priority to US12/523,407 priority patent/US20100113506A1/en
Publication of WO2008088030A1 publication Critical patent/WO2008088030A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　クロピドグレル、及びその製薬学上許容しうる塩からなる群から選ばれる少なくとも１つ、並びに、イコサペント酸、その製薬学上許容しうる塩およびエステルからなる群から選ばれる少なくとも１つを有効成分として併用する、血栓もしくは塞栓に関連する疾患の予防または治療用組成物を提供する。
PCT/JP2008/050554 2007-01-17 2008-01-17 血栓もしくは塞栓に関連する疾患の予防又は治療用組成物 WO2008088030A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES08703408.8T ES2524320T3 (es) 2007-01-17 2008-01-17 Composición para la prevención o el tratamiento de enfermedad asociada con trombo o émbolo
EP08703408.8A EP2119443B1 (en) 2007-01-17 2008-01-17 Composition for prevention or treatment of disease associated with thrombus or embolus
CA2675836A CA2675836C (en) 2007-01-17 2008-01-17 Composition for preventing or treating thrombus- or embolus-associated disease
JP2008554086A JP5345402B2 (ja) 2007-01-17 2008-01-17 血栓もしくは塞栓に関連する疾患の予防又は治療用組成物
US12/523,407 US20100113506A1 (en) 2007-01-17 2008-01-17 Composition for preventing or treating thrombus- or embolus- associated disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007008590 2007-01-17
JP2007-008590 2007-01-17

Publications (1)

Publication Number Publication Date
WO2008088030A1 true WO2008088030A1 (ja) 2008-07-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050554 WO2008088030A1 (ja) 2007-01-17 2008-01-17 血栓もしくは塞栓に関連する疾患の予防又は治療用組成物

Country Status (6)

Country Link
US (1) US20100113506A1 (ja)
EP (1) EP2119443B1 (ja)
JP (1) JP5345402B2 (ja)
CA (1) CA2675836C (ja)
ES (1) ES2524320T3 (ja)
WO (1) WO2008088030A1 (ja)

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WO2009087938A1 (ja) * 2008-01-10 2009-07-16 Takeda Pharmaceutical Company Limited カプセル製剤
WO2010021385A1 (ja) * 2008-08-22 2010-02-25 持田製薬株式会社 Ａｎｃａ関連血管炎治療薬
JP2012500385A (ja) * 2008-08-06 2012-01-05 インビトロックス，インコーポレイテッド 生物学的応用における集束光散乱技術の使用
WO2012067152A1 (ja) * 2010-11-16 2012-05-24 三菱化学株式会社 Endothelial Protein C Receptor蛋白質による脳梗塞の検査方法
JPWO2011065444A1 (ja) * 2009-11-27 2013-04-18 学校法人東海大学 抗血栓剤
WO2014003454A1 (en) * 2012-06-28 2014-01-03 Lg Life Sciences Ltd. Oral dosage form product of clopidogrel hydrogen sulfate with improved stability
JP2014531444A (ja) * 2011-09-15 2014-11-27 オムセラ・ファーマシューティカルズ・インコーポレイテッド 抗血小板療法に対する耐性を治療するか、逆転させるか、阻害するかまたは防止するための方法および組成物
JP2018521018A (ja) * 2015-06-03 2018-08-02 ウィスコンシン アラムニ リサーチ ファンデーション 虚血性疾患または虚血性損傷を処置するための心臓線維芽細胞由来細胞外マトリックスおよびその注射可能製剤
JP2020537696A (ja) * 2017-10-18 2020-12-24 高麗製薬株式会社Ｋｏｒｅａｎ Ｄｒｕｇ Ｃｏ．，Ｌｔｄ． 野せり抽出物および抗血栓剤を含む抗血栓用組成物

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AU2013207368A1 (en) 2012-01-06 2014-07-24 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-CRP) in a subject
CN111840269A (zh) 2012-06-29 2020-10-30 阿玛林制药爱尔兰有限公司 在接受抑制素治疗的受试者中降低心血管事件风险的方法
US20150265566A1 (en) 2012-11-06 2015-09-24 Amarin Pharmaceuticals Ireland Limited Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
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US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
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US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009087938A1 (ja) * 2008-01-10 2009-07-16 Takeda Pharmaceutical Company Limited カプセル製剤
JP2012500385A (ja) * 2008-08-06 2012-01-05 インビトロックス，インコーポレイテッド 生物学的応用における集束光散乱技術の使用
WO2010021385A1 (ja) * 2008-08-22 2010-02-25 持田製薬株式会社 Ａｎｃａ関連血管炎治療薬
EP2324827A1 (en) * 2008-08-22 2011-05-25 Mochida Pharmaceutical Co., Ltd. Therapeutic agent for anca-related vasculitis
JPWO2010021385A1 (ja) * 2008-08-22 2012-01-26 持田製薬株式会社 Ａｎｃａ関連血管炎治療薬
EP2324827A4 (en) * 2008-08-22 2012-04-25 Mochida Pharm Co Ltd THERAPEUTIC ACTIVE FOR ANCA-ASSOCIATED VASCULITIDES
JPWO2011065444A1 (ja) * 2009-11-27 2013-04-18 学校法人東海大学 抗血栓剤
WO2012067152A1 (ja) * 2010-11-16 2012-05-24 三菱化学株式会社 Endothelial Protein C Receptor蛋白質による脳梗塞の検査方法
JP2014531444A (ja) * 2011-09-15 2014-11-27 オムセラ・ファーマシューティカルズ・インコーポレイテッド 抗血小板療法に対する耐性を治療するか、逆転させるか、阻害するかまたは防止するための方法および組成物
WO2014003454A1 (en) * 2012-06-28 2014-01-03 Lg Life Sciences Ltd. Oral dosage form product of clopidogrel hydrogen sulfate with improved stability
JP2018521018A (ja) * 2015-06-03 2018-08-02 ウィスコンシン アラムニ リサーチ ファンデーション 虚血性疾患または虚血性損傷を処置するための心臓線維芽細胞由来細胞外マトリックスおよびその注射可能製剤
JP2022066207A (ja) * 2015-06-03 2022-04-28 ウィスコンシン アラムニ リサーチ ファンデーション 虚血性疾患または虚血性損傷を処置するための心臓線維芽細胞由来細胞外マトリックスおよびその注射可能製剤
JP7468983B2 (ja) 2015-06-03 2024-04-16 ウィスコンシン アラムニ リサーチ ファンデーション 虚血性疾患または虚血性損傷を処置するための心臓線維芽細胞由来細胞外マトリックスおよびその注射可能製剤
JP7535070B2 (ja) 2015-06-03 2024-08-15 ウィスコンシン アラムニ リサーチ ファンデーション 虚血性疾患または虚血性損傷を処置するための心臓線維芽細胞由来細胞外マトリックスおよびその注射可能製剤
JP2020537696A (ja) * 2017-10-18 2020-12-24 高麗製薬株式会社Ｋｏｒｅａｎ Ｄｒｕｇ Ｃｏ．，Ｌｔｄ． 野せり抽出物および抗血栓剤を含む抗血栓用組成物
JP2022062186A (ja) * 2017-10-18 2022-04-19 高麗製薬株式会社 野せり抽出物および抗血栓剤を含む抗血栓用組成物
JP7339698B2 (ja) 2017-10-18 2023-09-06 高麗製薬株式会社 野せり抽出物および抗血栓剤を含む抗血栓用組成物

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JPWO2008088030A1 (ja) 2010-05-13
EP2119443A1 (en) 2009-11-18
EP2119443A4 (en) 2010-03-03
CA2675836A1 (en) 2008-07-24
ES2524320T3 (es) 2014-12-05
JP5345402B2 (ja) 2013-11-20
EP2119443B1 (en) 2014-08-20
CA2675836C (en) 2016-10-11
US20100113506A1 (en) 2010-05-06

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