WO2007129184A3 - An improved process for the preparation of phenytoin sodium - Google Patents

An improved process for the preparation of phenytoin sodium Download PDF

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Publication number
WO2007129184A3
WO2007129184A3 PCT/IB2007/001130 IB2007001130W WO2007129184A3 WO 2007129184 A3 WO2007129184 A3 WO 2007129184A3 IB 2007001130 W IB2007001130 W IB 2007001130W WO 2007129184 A3 WO2007129184 A3 WO 2007129184A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
phenytoin sodium
phenytoin
sodium
Prior art date
Application number
PCT/IB2007/001130
Other languages
French (fr)
Other versions
WO2007129184A2 (en
Inventor
Siripragada Mahender Rao
Padmanabhan Ramar
Original Assignee
Orchid Chemicals & Pharm Ltd
Siripragada Mahender Rao
Padmanabhan Ramar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd, Siripragada Mahender Rao, Padmanabhan Ramar filed Critical Orchid Chemicals & Pharm Ltd
Publication of WO2007129184A2 publication Critical patent/WO2007129184A2/en
Publication of WO2007129184A3 publication Critical patent/WO2007129184A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of Phenytoin Sodium of formula (I) by reacting Phenytoin with aqueous solution of Sodium hydroxide in presence of aqueous Sodium chloride.
PCT/IB2007/001130 2006-05-04 2007-05-02 An improved process for the preparation of phenytoin sodium WO2007129184A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN806CH2006 2006-05-04
IN806/CHE/2006 2006-05-04

Publications (2)

Publication Number Publication Date
WO2007129184A2 WO2007129184A2 (en) 2007-11-15
WO2007129184A3 true WO2007129184A3 (en) 2009-06-04

Family

ID=38668137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/001130 WO2007129184A2 (en) 2006-05-04 2007-05-02 An improved process for the preparation of phenytoin sodium

Country Status (1)

Country Link
WO (1) WO2007129184A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111978258B (en) * 2020-08-13 2021-05-25 山西新宝源制药有限公司 Method for preparing phenytoin sodium

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109456271B (en) * 2018-11-20 2022-06-21 宁波职业技术学院 Synthesis method of phenytoin sodium

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245917B1 (en) * 1998-03-20 2001-06-12 Warner-Lambert Company Crystalline sodium phenytoin monohydrate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245917B1 (en) * 1998-03-20 2001-06-12 Warner-Lambert Company Crystalline sodium phenytoin monohydrate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NI, N. ET AL.: "Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 89, no. ISS.12, 17 October 2000 (2000-10-17), pages 1620 - 1625 *
SWABRICK, J ET AL., ENCYCLOPEDIA OF PHARMACEUTICAL TECHNOLOGY, vol. 20, no. SUPPLE, 2001, pages 500, ISBN: 082472819X, Retrieved from the Internet <URL:https://books.google.com/books?id=gJYv8mdG0iEC8&pg=PP1&dq=Encyclopedia+of+Pharmaceutical+Technology:+Volume+20+-+Supplement+3&client=firefox-a> *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111978258B (en) * 2020-08-13 2021-05-25 山西新宝源制药有限公司 Method for preparing phenytoin sodium

Also Published As

Publication number Publication date
WO2007129184A2 (en) 2007-11-15

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