WO2007081630A2 - Substituted pyrimidinyl kinase inhibitors - Google Patents

Substituted pyrimidinyl kinase inhibitors Download PDF

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Publication number
WO2007081630A2
WO2007081630A2 PCT/US2006/061890 US2006061890W WO2007081630A2 WO 2007081630 A2 WO2007081630 A2 WO 2007081630A2 US 2006061890 W US2006061890 W US 2006061890W WO 2007081630 A2 WO2007081630 A2 WO 2007081630A2
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WIPO (PCT)
Prior art keywords
amino
galkyl
pyrimidine
carbaldehyde
oxime
Prior art date
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PCT/US2006/061890
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French (fr)
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WO2007081630A3 (en
Inventor
Guozhang Xu
Lily Lee
Peter J. Connolly
Steven A. Middleton
Stuart L. Emanuel
Terry V. Hughes
Marta C. Abad
Prabha S. Karnachi
Steven K. Wetter
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Janssen Pharmaceutica, N.V.
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Publication of WO2007081630A2 publication Critical patent/WO2007081630A2/en
Publication of WO2007081630A3 publication Critical patent/WO2007081630A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • the present invention is in the area of substituted pyrimidine compounds and forms thereof and methods of preparation and use thereof as kinase inhibitors.
  • protein kinases are the largest set of structurally related phosphoryl transferases, have highly conserved structures and catalytic functions and may be categorized into families by the substrates they phosphorylate (e.g., protein-tyrosine, protein-serine/threonine, histidine and the like) and are responsible for the control of a wide variety of cellular signal transduction processes.
  • phosphorylate e.g., protein-tyrosine, protein-serine/threonine, histidine and the like
  • protein-tyrosine kinases examples include, but are not limited to, Irk,
  • IGFR-I Zap-70, Bmx, Btk, CHK (Csk homologous kinase), CSK (C-terminal Src Kinase), Itk-1, Src (c-Src, Lyn, Fyn, Lck, Syk, Hck, Yes, BIk, Fgr and Frk), Tec, Txk/Rlk, AbI, EGFR (EGFR- 1/ErbB-l, ErbB-2/NEU/HER-2, ErbB-3 and ErbB-4), FAK, FGFlR (also FGFRl or FGR-I), FGF2R (also FGR-2), MET (also Met-1 or c- MET), PDGFR ( ⁇ and ⁇ ), Tie-1, Tie-2 (also Tek-1 or Tek), VEGFRI (also FLT-I),
  • VEGFR2 (also KDR), FLT-3, FLT- 4, c-KIT, JAKl, JAK2, JAK3, TYK2, LOK, RET, TRKA, PYK2, ALK (Anaplastic Lymphoma Kinase), EPHA (1-8), EPHB (1-6), RON, Fes, Fer or EPHB4 (also EPHB4-1).
  • protein-serine/threonine kinases include, but are not limited to, Ark, ATM (1-3), CamK (I-IV), CamKK, Chkl and 2 (Checkpoint kinases), CKI, CK2, Erk, IKK- 1 (also IKK-ALPHA or CHUK), IKK-2 (also IKK-BETA), Ilk, Jnk (1-3), LimK (1 and 2), MLK3Raf (A, B, and C), CDK (1-10), PKC (including all PKC subtypes), PIk (1-3), NIK, Pak (1-3), PDKl, PKR, RhoK, RIP, RIP-2, GSK3 ( ⁇ and ⁇ ), PKA, P38, Erk (1-3), PKB (including all PKB subtypes) (also AKT-I, AKT-2, AKT-3 or AKT3-1), IRAKI, FRK, SGK, TAKl or Tpl-2 (also COT).
  • Protein kinases play very important roles in the normal regulation of cell growth. However, as a result of dysregulation of the tyrosine kinases (receptor or non- receptor) or the ligands of the receptor tyrosine kinases, signaling can become deregulated, resulting in uncontrolled cell proliferation leading to cancer or a related disease, disorder or syndrome.
  • tyrosine kinases receptor or non- receptor
  • ligands of the receptor tyrosine kinases signaling can become deregulated, resulting in uncontrolled cell proliferation leading to cancer or a related disease, disorder or syndrome.
  • Protein kinases catalyze and regulate the process of phosphorylation, whereby the kinases covalently attach phosphate groups to proteins or lipid targets in response to a variety of extracellular signals: hormones, neurotransmitters, growth and differentiation factors, cell cycle events, environmental stresses, nutritional stresses and the like.
  • Phosphorylation modulates or regulates a variety of cellular processes such as proliferation, growth, differentiation, metabolism, apoptosis, motility, transcription, translation and other signaling processes.
  • Defective control of protein phosphorylation due to unregulated cellular mitosis, unregulated cell proliferation and upregulated kinase activity has been implicated in a number of diseases and disease conditions, such as osteoarthritis, rheumatoid arthritis, synovial pannus invasion in arthritis, multiple sclerosis, myasthenia gravis, diabetes mellitus, diabetic angiopathy, diabetic retinopathy, retinal vessel proliferation, inflammatory bowel disease, Crohn's disease, ulcerative colitis, bone diseases, transplant or bone marrow transplant rejection, lupus, chronic pancreatitis, cachexia, septic shock, f ⁇ broproliferative and differentiative skin diseases or disorders, central nervous system diseases, neurodegenerative diseases, disorders or conditions related to nerve damage and axon degeneration subsequent to
  • myasthenia gravis means a disease having the characteristic feature of easy fatigue of certain voluntary muscle groups on repeated use. Muscles of the face or upper trunk are especially likely to be affected. In most and perhaps all cases, the disease is due to the development of autoantibodies against the acetylcholine receptor in neuromuscular junctions. Immunization of animals with this receptor protein leads to a disease with the features of myasthenia gravis.
  • pannus means a disease whereby vascularised granulation tissue rich in fibroblasts, lymphocytes and macrophages, derived from synovial tissue, overgrows the bearing surface of the joint in rheumatoid arthritis and is associated with the breakdown of the articular surface.
  • the tyrosine kinases can further be categorized by whether they are receptor tyrosine kinases or non-receptor tyrosine kinases.
  • the receptor tyrosine kinases span the cell membrane with a ligand interacting domain protruding from the cell, with a hydrophobic trans-membrane domain, and a cytoplasmic domain that contains the catalytic kinase domain and other regulatory sequences.
  • Non-receptor tyrosine kinases are often myristylated or modified by the addition of other hydrophobic moieties that allow them to be anchored to the cell membrane.
  • the epidermal growth factor receptor (EGFR) tyrosine-kinase family includes the receptors EGFR (also referred to as EGFR-I or Erb-Bl), HER-2 (or neu), EGFR3 and EGFR4.
  • EGFR epidermal Growth Factor
  • TGF- ⁇ Transforming Growth Factor- ⁇
  • HER-2 ligand heregulin are three of the ligands that bind to the EGFR receptors.
  • EGFR overexpression or mutation of one or more EGFR kinase family members has been commonly involved in cancer and other diseases characterized by uncontrolled or abnormal cell growth.
  • Deregulation of EGFR has also been associated with epidermoid tumors, head and neck tumors, breast tumors and tumors involving other major organs, such as the lungs and gastrointestinal tract.
  • the clinically prevalent cancers related to EGFR include lung, gastric and head and neck cancer (Klijn JG, Berns PM, Schmitz PI and Foekens JA;
  • Diseases associated with increased EGFR expression include proliferative glomerulonephritis, diabetes-induced renal disease and chronic pancreatitis.
  • EGFR inhibitors tested in neurite outgrowth assays have activity in promoting neurite outgrowth in both cerebellar granule cells and dorsal root ganglion neurons, likely by acting directly on neurons to block neuronal inhibitory responses to myelin inhibitors, and thus an EGFR inhibitor may have potential use for promoting axon regeneration after brain and spinal cord injury (V. Koprivica, et al, EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans, Science, 2005, 310, 106).
  • HERl and HER2 overexpression has been implicated in a variety of cancers, such as bladder, breast, colorectal, endometrial, esophageal, gastric(stomach), glioma head and neck, lung (non-small cell lung cancer), ovarian, pancreatic, renal and prostate cancer.
  • HERl overexpression is found in breast, renal cell, lung, colorectal, head and neck, ovarian, pancreatic, glioma, bladder, esophageal, gastric, endometrial and cervical cancer tumors; in contrast, HER2 overexpression is found in esophageal, head and neck, lung, gastric, renal cell, breast, bladder, ovarian and colorectal, prostate and endometrial cancer tumors (Horizons in Cancer Therapeutics: From Bench to Bedside, Signal Transduction Inhibitors, 2001, 2(2), ISSN 1532-3048).
  • HER2 has been found to be responsible for these clinically prevalent cancers (Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A and McGuire WL; Human breast cancer: Correlation of relapse and survival with amplification of HER-2/neu oncogene, Science, 1987, 235, 177-82; Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, et al; Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer, Science, 1989, 244, 707-712; Hetzel DJ, Wilson TO, Keeney GL, Roche PC, Cha SS and Podrantz KC; HER-2/neu expression: A major prognostic factor in endometrial cancer, Gynecol. Oncol, 1992, 47, 179-85).
  • CMV Human cytomegalovirus
  • EGFR Human cytomegalovirus
  • the human CMV uses the EGFR receptor to enter cells during infection, EGFR is autophosphorylated and the downstream signal transduction pathway components are activated; however, the EGFR specific inhibitor tyrphostin AG 1478 has been shown to reduce the viral load in cells that were infected in the presence of the tyrphostin (Wang X, et al., Nature, 24 July 2003, Vol. 424, 456-461).
  • potent EGFR selective inhibitors may be useful in anti-CMV therapy.
  • Certain oxime substituted pyrimidines are registered by the Chemical Abstracts Society (CAS) such as 4,6-diamino-5-pyrimidinecarboxaldehyde oxime (CAS Registry No. : 109831 -69-8) and N,N'-dimethyl-5-[(methylimino)methyl]-4,6-pyrimidinediamine (CAS Registry No.: 14160-97-5) and described in Heterocycles, 1987, 25(1), 343-5.
  • Certain references describe substituted pyrimidine compounds such as United States Patents: US 6,080,750, US 6,107,301 and US 6,833,378.
  • potent small-molecule kinase inhibitors of one or more of the EGFR, HER-I, HER-2 kinase proteins and the like possessing anti-tumor cell proliferation activity are useful for treating or ameliorating a EGFR, HER- 1 or HER-2 kinase receptor mediated, angiogenesis-mediated or hyperproliferative disorder.
  • the present invention is directed to a compound of formula (I):
  • An example of the present invention includes a compound of formula (I) and forms thereof as a protein kinase inhibitor.
  • An example of the present invention includes a prodrug form of a compound of formula (I) and forms thereof as a protein kinase inhibitor.
  • An example of the present invention includes a metabolite form of a compound of formula (I) and forms thereof as a protein kinase inhibitor.
  • An example of the present invention includes use of a compound of formula (I) and forms thereof as an inhibitor of a protein kinase such as EGFR, HER-I, HER-2 and the like comprising contacting the protein kinase domain or receptor with the compound.
  • a protein kinase such as EGFR, HER-I, HER-2 and the like
  • An example of the present invention includes the use of a compound of formula (I) and forms thereof as a pharmaceutical composition, medicine or medicament for treating, preventing or ameliorating a kinase mediated disease, disorder or condition.
  • An example of the present invention includes the use of a compound of formula (I) and forms thereof as a medicament.
  • An example of the present invention includes the use of a prodrug of a compound of formula (I) and forms thereof as a pharmaceutical composition, medicine or medicament for treating, preventing or ameliorating a kinase mediated disease, disorder or condition.
  • An example of the present invention includes the use of a prodrug of a compound of formula (I) and forms thereof as a medicament.
  • the present invention is further directed to a method for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I) and forms thereof.
  • An example of the present invention includes a method for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition in a subject in need thereof comprising administering to the subject an effective amount of a prodrug of a compound of formula (I) and forms thereof.
  • the present invention is directed to a compound of formula (I):
  • L is selected from a bond, Ci_ 6 alkyl or halo-Ci_ 6 alkyl;
  • Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-
  • Ci_8alkyl-amino or Ci_galkoxycarbonyl and wherein heterocyclyl-Ci.galkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl;
  • R 2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy
  • R3, R 4 , R5, Re and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl,
  • Ci.galkyl-amino-Ci.galkyl-amino-carbonyl Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C 3 _i 2 cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substitu
  • the present invention is directed to a compound of formula (II):
  • L is selected from a bond, Ci_ 6 alkyl or halo-Ci_ 6 alkyl;
  • Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-
  • Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl, Ci_galkyl-sulfonyl-Ci_galkyl, Ci_galkyl-sulfonyloxy-Ci_galkyl, aryl, aryl-Ci_ 8 alkyl, aryloxy-Ci_ 8 alkyl, heterocyclyl-Ci_ 8 alkyl, heterocyclyl-carbonyl-Ci_galkyl or heteroaryl-Ci_galkyl, wherein aryl-Ci_galkyl is optionally substitute
  • R 2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy
  • R3, R 4 , R5, R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl,
  • An example of a compound of formula (I) and forms thereof includes a compound wherein R A is cyano.
  • An example of a compound of formula (I) and forms thereof includes a compound wherein R A is an Ri substituted oxadiazole.
  • An example of a compound of formula (I) and forms thereof includes a compound wherein Ri is selected from hydrogen, Ci_ 8 alkyl, Ci_galkenyl, Ci_galkoxy, Ci_ 8 alkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl,
  • Ci_galkyl-amino or Ci_galkoxycarbonyl are examples of Ci_galkyl-amino or Ci_galkoxycarbonyl.
  • An example of a compound of formula (I) and forms thereof includes a compound wherein Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci_galkoxy-Ci_galkyl-amino-Ci_galkyl, Ci_galkyl-sulfonyl-Ci_galkyl, Ci_galkyl-sulfonyloxy-Ci_galkyl, aryl, aryl-Ci_galkyl, aryloxy-Ci_galkyl, heterocyclyl-Ci.galkyl, heterocyclyl-carbonyl-Ci_galkyl, benzofused- heterocyclyl-Ci_galkyl or heteroaryl-Ci_galkyl, wherein
  • An example of a compound of formula (I) and forms thereof includes a compound wherein Ri is selected from hydrogen, Ci_ 8 alkyl, Ci-salkenyl, Ci_ 8 alkoxy-Ci_ 8 alkyl, hydroxy-Ci-salkyl, hydroxy-Ci-salkoxy, Ci_ 8 alkyl-amino-Ci_ 8 alkyl, Ci-salkoxy-Ci-salkyl-amino-Ci-galkyl, Ci.galkyl-sulfonyloxy-Ci.galkyl, aryl, aryl-Ci_galkyl, aryloxy-Ci_galkyl, heterocyclyl-Ci.galkyl, heterocyclyl-carbonyl-Ci.galkyl, benzofused- heterocyclyl-Ci.galkyl or heteroaryl-Ci_galkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with Ci_galkoxy
  • An example of a compound of formula (I) and forms thereof includes a compound wherein R 2 is selected from hydrogen.
  • An example of a compound of formula (I) and forms thereof includes a compound wherein R 2 is selected from Ci_galkyl.
  • An example of a compound of formula (I) and forms thereof includes a compound wherein R 2 is selected from Ci_galkoxy.
  • An example of a compound of formula (I) and forms thereof includes a compound wherein R 3 , R 4 , R 5 , R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci-galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_ 8 acyl-amino, Ci_ 8 alk
  • An example of a compound of formula (I) and forms thereof includes a compound wherein R 3 , R 4 , R 5 , R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci-galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbon
  • An example of a compound of formula (I) and forms thereof includes a compound wherein R 3 , R 4 , R 5 , R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, halo-Ci_galkyl, halo-Ci_galkoxy, cyano-Ci_galkyl, Ci_galkyl-amino, Ci-galkyl-amino-Ci-galkyl-amino-carbonyl, Ci_ 8 alkoxy-imino-Ci_ 8 alkyl, Ci_ 8 alkoxy-imino-(aryl)Ci_ 8 alkyl, C 1-8 acyl, Ci_ 8 acyl-amino, Ci_ 8 alkoxycarbonyl, thio-Ci_ 8 alkyl, substituted phosphonic acid, C 3 _i 2 cycloalkyl, aryl, aryloxy, aryl-amino, aryl-C
  • An example of a compound of formula (I) and forms thereof includes a compound wherein
  • L is selected from a bond, Ci_ 6 alkyl or halo-Ci_ 6 alkyl;
  • Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-
  • Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_ 8 alkoxy-Ci_ 8 alkyl, hydroxy-Ci_ 8 alkyl, hydroxy-Ci_ 8 alkoxy, Ci_ 8 alkyl-amino-Ci_ 8 alkyl, Ci-salkoxy-Ci-salkyl-amino-Ci-salkyl, Ci_ 8 alkyl-sulfonyloxy-Ci_ 8 alkyl, aryl, aryl-Ci.galkyl, aryloxy-Ci_galkyl, heterocyclyl-Ci.galkyl, heterocyclyl-carbonyl-Ci.galkyl, benzofused-heterocyclyl-Ci.galkyl or heteroaryl-Ci_galkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with Ci_galkoxy, and wherein heterocyclyl-Ci_galkyl is optional
  • R 3 , R 4 , R 5 , R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl,
  • An example of a compound of formula (I) and forms thereof includes a compound wherein
  • L is selected from a bond, Ci_ 6 alkyl or halo-Ci_ 6 alkyl
  • Ar is selected from phenyl, naphthalenyl, 1,2,3,4-tetrahydro-naphthalenyl, 5,6,7,8- tetrahydro-naphthalenyl, pyridinyl, pyridiminyl, indazolyl, indolyl, benzofuranyl, benzoimidazolyl, benzothiazolyl, benzo[l,3]dioxolyl, 2,3- dihydro-indolyl, 1,2,3,4-tetrahydro-phthalazinyl or indanyl;
  • Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, Ci_galkyl-amino-Ci_galkyl,
  • R3, R 4 , R5, R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl,
  • An example of a compound of formula (I) and forms thereof includes a compound wherein
  • L is a bond
  • Ar is selected from phenyl, 1,2,3,4-tetrahydro-naphthalenyl, pyridinyl, indazolyl or indolyl;
  • Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, hydroxy-Ci_galkyl, morpholin-4- yl-Ci_ 8 alkyl or piperidinyl-Ci_ 8 alkyl;
  • R 2 is hydrogen
  • R3, R 4 , R5, R 6 and R 7 is each selected from hydrogen, halogen, phenoxy, phenyl-Ci_8alkyl or phenyl-Ci-salkoxy, wherein phenyl-Ci_galkyl is optionally substituted on phenyl with halogen.
  • the present invention is further directed to a compound of formula (Ia):
  • L is selected from a bond, Ci_ 6 alkyl or halo-Ci_ 6 alkyl
  • Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl,
  • Ci.galkyl-amino-Ci.galkyl Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl,
  • Ci.galkyl-amino or Ci_galkoxycarbonyl and wherein heterocyclyl-Ci-salkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_galkyl, Ci.galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl;
  • R 2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and
  • R3, R 4 , R5, R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl,
  • the present invention is further directed to a compound of formula (Ib):
  • Ri is selected from hydrogen, Ci_ 8 alkyl, Ci_ 8 alkenyl, Ci_ 8 alkoxy, Ci_ 8 alkoxy-Ci_ 8 alkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl, Ci_ 8 alkyl-sulfonyl-Ci_ 8 alkyl, Ci_ 8 alkyl-sulfonyloxy-Ci_ 8 alkyl, aryl, aryl-Ci_ 8 alkyl, aryloxy-Ci_ 8 alkyl, heterocyclyl-Ci-salkyl, heterocyclyl-carbonyl-Ci_ 8 alkyl, benzofused-heterocyclyl-Ci-salkyl or heteroaryl-Ci_ 8 alkyl, wherein aryl
  • the present invention is further directed to a compound of formula (Ic):
  • L is selected from a bond, Ci_ 6 alkyl or halo-Ci_ 6 alkyl
  • Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused- C 3 -i 2 cycloalkyl;
  • R 2 is selected from hydrogen, Ci.galkyl or Ci_galkoxy
  • R3, R 4 , R5, R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci_ 8 alkoxy, Ci_ 8 alkoxy-Ci_salkyl, hydroxy-Ci_ 8 alkyl, halo-Ci_salkyl, hydroxy-Ci_8alkoxy, halo-Ci_salkoxy, cyano-Ci_8alkyl, amino, Ci_8alkyl-amino, amino-Ci_ 8 alkyl, Ci_ 8 alkyl-amino-Ci_ 8 alkyl,
  • Ci.galkyl-amino-Ci.galkyl-amino-carbonyl Ci_ 8 alkoxy-imino-Ci_ 8 alkyl, Ci_ 8 alkoxy-imino-(aryl)Ci_ 8 alkyl, carboxy, Ci_sacyl, Ci_gacyl-amino, Ci.galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C 3 -i 2 cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_ 8 alkyl, aryl-Ci_ 8 alkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the
  • An example of a compound of formula (Ic) and forms thereof includes a compound wherein R 2 is selected from hydrogen.
  • An example of a compound of formula (Ic) and forms thereof includes a compound wherein R 3 , R 4 , R 5 , R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_ 8 alkyl, Ci_galkoxy, Ci_ 8 alkoxy-Ci_ 8 alkyl, hydroxy-Ci_ 8 alkyl, halo-Ci_ 8 alkyl, hydroxy-Ci_ 8 alkoxy, halo-Ci_ 8 alkoxy, cyano-Ci_ 8 alkyl, amino, Ci_ 8 alkyl-amino, amino-Ci_ 8 alkyl, Ci_ 8 alkyl-amino-Ci_ 8 alkyl, Ci-galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_ 8 alkoxy-imino-Ci_ 8 alkyl, Ci_ 8 alkoxy-imino-(aryl)Ci_ 8 alkyl, carboxy, Ci_ 8 acy
  • An example of a compound of formula (Ic) and forms thereof includes a compound wherein R 3 , R 4 , R 5 , R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci.galkyl, Ci.galkoxy, Ci.galkoxy-Ci.galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci-galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxy
  • An example of a compound of formula (Ic) and forms thereof includes a compound wherein R 3 , R 4 , R 5 , R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_ 8 alkyl, Ci.galkoxy, halo-Ci_ 8 alkyl, halo-Ci_ 8 alkoxy, cyano-Ci_ 8 alkyl, Ci_ 8 alkyl-amino, Ci-salkyl-amino-Ci-salkyl-amino-carbonyl, Ci_ 8 alkoxy-imino-Ci_ 8 alkyl, Ci_ 8 alkoxy-imino-(aryl)Ci_ 8 alkyl, Ci_sacyl, Ci_ 8 acyl-amino, Ci_ 8 alkoxycarbonyl, thio-Ci_salkyl, substituted phosphonic acid, C 3 _i 2 cycloalkyl, aryl, aryloxy, aryl-amin
  • An example of a compound of formula (Ic) and forms thereof includes a compound wherein L is selected from a bond, Ci_ 6 alkyl or halo-Ci_ 6 alkyl;
  • Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-
  • R 2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy
  • R3, R 4 , R5, R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, halo-Ci_galkyl, halo-Ci_galkoxy, cyano-Ci_galkyl, Ci_galkyl-amino,
  • Ci.galkyl-amino-Ci.galkyl-amino-carbonyl Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C 3 _i 2 cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused- heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_galkoxy substituents, where
  • the present invention is further directed to a compound of formula (Id):
  • L is selected from a bond, Ci_ 6 alkyl or halo-Ci_ 6 alkyl;
  • R 2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy;
  • R3, R 4 , R5, R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci_ 8 alkoxy, Ci_ 8 alkoxy-Ci_ 8 alkyl, hydroxy-Ci_salkyl, halo-Ci_ 8 alkyl, hydroxy-Ci_8alkoxy, halo-Ci_salkoxy, cyano-Ci_8alkyl, amino, Ci_8alkyl-amino, amino-Ci_ 8 alkyl, Ci_ 8 alkyl-amino-Ci_ 8 alkyl,
  • Ci.galkyl-amino-Ci.galkyl-amino-carbonyl Ci_ 8 alkoxy-imino-Ci_ 8 alkyl
  • the present invention is further directed to a compound of formula (Ie):
  • L is selected from a bond, Ci_ 6 alkyl or halo-Ci_ 6 alkyl
  • R 2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy
  • R 3 is selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy,
  • Ci.gacyl or Ci_galkoxycarbonyl are Ci.gacyl or Ci_galkoxycarbonyl.
  • the present invention is further directed to a compound of formula (If):
  • Xi and X 2 is each selected from -C(Re)- or -N-, wherein Xi and X 2 are not the same;
  • L is selected from a bond, C ⁇ alkyl or halo-Ci_ 6 alkyl;
  • Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl, Ci_ 8 alkyl-sulfonyl-Ci_ 8 alkyl, Ci_ 8 alkyl-sulfonyloxy-Ci_ 8 alkyl, aryl, aryl-Ci_ 8 alkyl, aryloxy-Ci_ 8 alkyl, heterocyclyl-Ci_ 8 alkyl, heterocyclyl-carbonyl-Ci_ 8 alkyl, benzofused-heterocyclyl-Ci-salkyl or heteroaryl-Ci_ 8 alkyl, wherein aryl-Ci_gal
  • Ci_ 8 alkyl-amino or Ci-salkoxycarbonyl and wherein heterocyclyl-Ci-salkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_ 8 alkyl, Ci.galkoxy, amino, Ci_8alkyl-amino or Ci-salkoxycarbonyl;
  • R 2 is selected from hydrogen, Ci-salkyl or Ci-salkoxy
  • R3, R 4 , and R5 is each selected from hydrogen, halogen, hydroxy, Ci-salkyl, Ci-salkoxy,
  • Ci_galkoxy-imino-Ci_galkyl Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl,
  • Ci_galkyl-amino-Ci_galkyl Ci_galkyl-amino-Ci_galkyl.
  • An example of a compound of Formula (I) includes a compound and forms thereof, wherein (*)-RA, R 2 , R3, R4, R5, Re, R7, L and Ar are dependently selected from (wherein * represents the configuration of the oxime portion in relationship to the double bond; further, when one or more of R 3 , R 4 , R 5 , R 6 or R 7 is hydrogen, the hydrogen is omitted from the following table): Cpd (*)-R A R 2 L (R 3 -R 4 -R 5 -Re-R 7 )Ar
  • Examples of a compound of Formula (I) include compounds selected from the group consisting of:
  • Bond lines drawn into a ring system from a substituent variable indicate that the substituent may be attached to any of the substitutable ring atoms.
  • Ci-salkyl means a saturated aliphatic branched or straight-chain hydrocarbon radical or linking group having from 1 up to 8 carbon atoms in a linear or branched arrangement, wherein the radical is derived by the removal of one hydrogen atom from a carbon atom and the linking group is derived by the removal of one hydrogen atom from each of two carbon atoms in the chain.
  • Ci-salkyl also includes a "Ci_ 6 alkyl” and “Ci_ 4 alkyl” radical or linking group having from 1 up to 6 carbon atoms and 1 up to 4 carbon atoms respectively, such as methyl, ethyl, 1 -propyl, 2-propyl, 1 -butyl, 2-butyl, tert-butyi, 1-pentyl, 2-pentyl, 3-pentyl, 1-hexyl, 2-hexyl, 3- hexyl, 1-heptyl, 2-heptyl, 3-heptyl, 1-octyl, 2-octyl, 3-octyl and the like.
  • Alkyl radicals may be attached to a core molecule via a terminal carbon atom or via a carbon atom within the chain.
  • substituent variables may be attached to an alkyl linking group when allowed by available valences.
  • C 2 -salkenyl means an alkyl radical or linking group having from 2 up to 8 carbon atoms in a linear or branched arrangement having at least one carbon- carbon double bond.
  • C 2 -salkenyl also includes a "C 2 - 4 alkenyl” radical or linking group having from 2 up to 4 carbon atoms, such as ethenyl (also referred to as vinyl), ⁇ o-propenyl, allyl (also referred to as propenyl), propylidene and the like.
  • Ci-salkoxy means an alkyl radical or linking group having from 1 up to 8 carbon atoms in a linear or branched arrangement, wherein the radical or linking group is attached through an oxygen linking atom, as in the formula: -O-Ci_ 8 alkyl.
  • the term "Ci-salkoxy” also includes a "Ci_6alkoxy” and “Ci_4alkoxy” radical or linking group having from 1 up to 6 carbon atoms and from 1 up to 4 carbon atoms respectively, such as methoxy, ethoxy, propoxy, butoxy and the like.
  • An alkoxy radical may be attached to a core molecule and further substituted as a linking group where indicated.
  • C3_i2cycloalkyl means a saturated or partially unsaturated cyclic hydrocarbon ring system radical.
  • Cs. ⁇ cycloalkyl also includes a C 3 - 8 cycloalkyl, Cs-iocycloalkyl, Cs- ⁇ cycloalkyl, Cs-scycloalkyl, Cs- ⁇ cycloalkyl, C 9 _i 3 Cycloalkyl or benzofused-Cs. ⁇ cycloalkyl ring system radical and the like, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, lH-indenyl, indanyl, 9 ⁇ -fluorenyl, 1,2,3,4-tetrahydro-naphthalenyl, acenaphthenyl, adamantanyl and the like.
  • benzofused-Cs. ⁇ cycloalkyl means a C 3 _i 2 cycloalkyl ring system radical having a benzene ring fused on the ring system on adjacent carbons.
  • Examples of benzofused-Cs- ⁇ cycloalkyl in compounds representative of the present invention include a benzofused-Cs- ⁇ cycloalkyl ring system radical and the like, such as lH-indenyl, indanyl and the like.
  • aryl means an unsaturated aromatic hydrocarbon ring system radical.
  • Aryl ring systems include phenyl, naphthalenyl, azulenyl, anthracenyl and the like.
  • aryl in compounds representative of the present invention include phenyl or naphthalenyl.
  • hetero when used as a prefix for a ring system, refers to the replacement of at least one carbon atom member in the ring system with a heteroatom selected from N, O, S, S(O), or SO 2 .
  • a hetero ring may have 1, 2, 3 or 4 carbon atom members replaced by a nitrogen atom.
  • a ring may have 1 , 2 or 3 nitrogen atom members and 1 oxygen or sulfur atom member.
  • a ring may have 1 oxygen or sulfur atom member.
  • up to two adjacent ring members may be heteroatoms, wherein one heteroatom is nitrogen and the other heteroatom is selected from N, S or O.
  • heterocyclyl means a saturated or partially unsaturated “hetero” ring system radical.
  • Heterocyclyl ring systems include azetidinyl, 2H-pyrrole, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolidinyl, 1,3-dioxolanyl, 2-imidazolinyl (also referred to as 4,5- dihydro-lH-imidazolyl), imidazolidinyl, 2-pyrazolinyl, pyrazolidinyl, tetrazolyl, tetrazolidinyl, piperidinyl, 1 ,4-dioxanyl, morpholinyl, 1 ,4-dithianyl, thiomorpholinyl, piperazinyl, azepanyl, hexahydro-l,4-diazepinyl, hexahydro-l,4-oxazepanyl,
  • heterocyclyl also includes a benzofused-heterocyclyl ring system radical and the like, such as indolinyl (also referred to as 2,3-dihydro-indolyl), benzo[l,3]dioxolyl, 2,3-dihydro-l,4-benzodioxinyl, 2,3-dihydro-benzofuranyl, 1,2- dihydro-phthalazinyl and the like.
  • indolinyl also referred to as 2,3-dihydro-indolyl
  • benzo[l,3]dioxolyl 2,3-dihydro-l,4-benzodioxinyl
  • 2,3-dihydro-benzofuranyl 1,2- dihydro-phthalazinyl and the like.
  • benzofused-heterocyclyl means a heterocyclyl ring system radical having a benzene ring fused on the ring system on adjacent carbons.
  • examples of benzofused-heterocyclyl in compounds representative of the present invention include benzo[l,3]dioxolyl and 2,3-dihydro-indolyl.
  • heteroaryl means a monovalent, unsaturated aromatic "hetero" ring system radical.
  • Heteroaryl ring systems include furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and the like.
  • heteroaryl also includes a benzofused-heteroaryl ring system radical and the like, such as indolizinyl, indolyl, azaindolyl, isoindolyl, benzofuranyl, benzothienyl, indazolyl, azaindazolyl, benzoimidazolyl, benzothiazolyl, benzoxazolyl, benzoisoxazolyl, benzothiadiazolyl, benzotriazolyl, purinyl, 4H-quinolizinyl, quinolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, 1,8- naphthyridinyl, pteridinyl and the like.
  • benzofused-heteroaryl means a heteroaryl ring system radical having a benzene ring fused on the ring system on adjacent carbons.
  • examples of benzofused-heteroaryl in compounds representative of the present invention include indazolyl, indolyl, benzofuranyl and benzoimidazolyl.
  • Ci_gacyl means a radical of the formula: -C(O)H or -C(O)-C i_galkyl, or a linking group of the formula: -C(O)-Ci_ 8 alkyl-terminal group.
  • Ci.gacyl-amino means a radical of the formula: -NH-C(O)H or -NH-C(O)-Ci_ 8 alkyl, or a linking group of the formula: -NH-C(O)-Ci_ 8 alkyl-terminal group.
  • Ci_ 8 alkoxy-Ci_ 8 alkyl means a radical of the formula: -Ci_ 8 alkyl-O-Ci_ 8 alkyl, or a linking group of the formula: -Ci-salkyl-O-Ci-salkyl-terminal group.
  • Ci.galkoxy-Ci.galkyl-amino-Ci.galkyl means a radical of the formula: -Ci_ 8 alkyl-NH-Ci_ 8 alkyl-O-Ci_ 8 alkyl,
  • Ci-salkoxycarbonyl means a radical of the formula: -C(O)-O-Ci_ 8 alkyl, or a linking group of the formula: -C(O)-O-Ci_ 8 alkyl-terminal group.
  • Ci_ 8 alkyl-amino means a radical of the formula: -NH-Ci_salkyl or -N(Ci_ 8 alkyl) 2 .
  • Ci_ 8 alkyl-amino-Ci_ 8 alkyl means a radical of the formula: -Ci.galkyl-NH-Ci.galkyl or -Ci_ 8 alkyl-N(Ci_ 8 alkyl) 2 , or a linking group of the formula: -Ci.galkyl-NH-Ci.galkyl-terminal group or -Ci_ 8 alkyl-N(Ci_ 8 alkyl)-Ci_ 8 alkyl-terminal group.
  • Ci-salkyl-amino-Ci-salkyl-amino-carbonyl means a radical of the formula: -C(O)-NH-Ci. 8 alkyl-NH-Ci. 8 alkyl or -C(O)-NH-Ci_8alkyl-N(Ci_8alkyl) 2 .
  • Ci.salkyl-sulfonyl-Ci.salkyl means a radical of the formula: -Ci_ 8 alkyl-SO 2 -Ci_ 8 alkyl, or a linking group of the formula: -Ci_ 8 alkyl-SO 2 -Ci_ 8 alkyl-terminal group.
  • Ci.galkyl-sulfonyloxy-Ci.galkyl means a radical of the formula:
  • -Ci_ 8 alkyl-O-SO 2 -Ci_galkyl or a linking group of the formula: -Ci_ 8 alkyl-O-SO 2 -Ci_ 8 alkyl-terminal group.
  • amino means a radical of the formula: -NH 2 .
  • amino-Ci_ 8 alkyl means a radical of the formula: -Ci_salkyl-NH 2 , or a linking group of the formula: -Ci_ 8 alkyl-NH-terminal group or -Ci_ 8 alkyl-N(terminal group) 2 .
  • aryl-amido means a radical of the formula: -NHC(O)-aryl.
  • aryl-amino means a radical of the formula: -NH-aryl.
  • aryl-Ci_ 8 alkyl means a radical of the formula: -Ci_ 8 alkyl-aryl.
  • aryl-carbonyl-Ci_ 8 alkyl means a radical of the formula:
  • aryl-Ci_ 8 alkoxy means a radical of the formula: -O-Ci_ 8 alkyl-aryl.
  • aryloxy means a radical of the formula: -O-aryl.
  • aryloxy-Ci-salkyl means a radical of the formula: -Ci_ 8 alkyl-O-aryl.
  • carboxy means a radical of the formula: -C(O)OH.
  • cyano-Ci-salkyl means a radical of the formula: -Ci_ 8 alkyl-C ⁇ N.
  • halogen or halo means the group chloro, bromo, fluoro or iodo.
  • halo-Ci_8alkoxy means a radical of the formula: -Ci_8alkoxy(halo)i_i7, wherein one or more halogen atoms may be substituted on Ci_galkoxy when allowed by available valences and includes monofluoromethoxy, difluoromethoxy, trifluoromethoxy, trifluoroethoxy and the like.
  • halo-Ci_6alkoxy means a radical of the formula: -Ci_6alkoxy(halo)i_i3, wherein one or more halogen atoms may be substituted on Ci_6alkoxy when allowed by available valences.
  • halo-Ci_ 8 alkyl means a radical of the formula: -Ci_ 8 alkyl(halo)i_i 7 , wherein one or more halogen atoms may be substituted on Ci_8alkyl when allowed by available valences and includes monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl and the like.
  • halo-Ci_6alkyl means a radical of the formula: -Ci_6alkyl(halo)i_i3, wherein one or more halogen atoms may be substituted on Ci_6alkyl when allowed by available valences.
  • heterocyclyl-Ci-salkyl means a radical of the formula: -Ci_8alkyl-heterocyclyl.
  • heterocyclyl-carbonyl-Ci-salkyl means a radical of the formula:
  • heteroaryl-Ci_galkoxy means a radical of the formula: -O-Ci_ 8 alkyl-heteroaryl.
  • heteroaryl-Ci.galkyl means a radical of the formula: -Ci_ 8 alkyl-heteroaryl.
  • heteroaryl-amino-sulfonyl means a radical of the formula: -SO 2 -NH-heteroaryl.
  • heteroaryloxy means a radical of the formula: -O-heteroaryl.
  • hydroxy-Ci-salkoxy means a radical wherein Ci_8alkoxy is substituted on an available carbon chain atom with one or more hydroxy radicals.
  • hydroxy-Ci.galkyl means a radical wherein Ci_galkyl is substituted on an available carbon chain atom with one or more hydroxy radicals.
  • thio-Ci_ 8 alkyl means a radical of the formula: -S-Ci_ 8 alkyl.
  • substituted means the independent replacement of one or more hydrogen atoms within a radical with that amount of substituents allowed by available valences.
  • dependency selected means that the structure variables are specified in an indicated combination.
  • terminal group means a moiety attached to a linking group substituent at a position other than the point of attachment of the linking group to the core molecule.
  • the moiety functions to terminate the structure variable.
  • IUPAC nomenclature rules are used herein.
  • form means, in reference to compounds of the present invention, such may exist as, without limitation, a salt, stereoisomer, tautomer, crystalline, polymorph, amorphous, solvate, hydrate, ester, prodrug or metabolite form.
  • the present invention encompasses all such compound forms and mixtures thereof.
  • isolated form means, in reference to compounds of the present invention, such may exist in an essentially pure state such as, without limitation, an enantiomer, a racemic mixture, a geometric isomer (such as a cis or trans stereoisomer), a mixture of geometric isomers, and the like.
  • the present invention encompasses all such compound forms and mixtures thereof.
  • the compounds of the invention may be present in the form of pharmaceutically acceptable salts.
  • the "pharmaceutically acceptable salts" of the compounds of this invention refer to non-toxic acidic/anionic or basic/cationic salt forms.
  • Suitable salt forms include acid addition salts which may, for example, be formed by mixing a solution of the compound according to the invention with a solution of an acid such as acetic acid, adipic acid, benzoic acid, carbonic acid, citric acid, fumaric acid, glycolic acid, hydrochloric acid, maleic acid, malonic acid, phosphoric acid, saccharinic acid, succinic acid, sulphuric acid, tartaric acid, trifluoroacetic acid and the like.
  • an acid such as acetic acid, adipic acid, benzoic acid, carbonic acid, citric acid, fumaric acid, glycolic acid, hydrochloric acid, maleic acid, malonic acid, phosphoric acid, saccharinic acid, succinic acid, sulphuric
  • suitable salts thereof may include alkali metal salts, e.g. sodium or potassium salts; alkaline earth metal salts, e.g. calcium or magnesium salts; and salts formed with suitable organic ligands, e.g. quaternary ammonium salts.
  • alkali metal salts e.g. sodium or potassium salts
  • alkaline earth metal salts e.g. calcium or magnesium salts
  • suitable organic ligands e.g. quaternary ammonium salts.
  • representative salts include the following: acetate, adipate, benzenesulfonate, benzoate, bicarbonate, bisulfate, bitartrate, borate, bromide, calcium, camsylate (or camphosulphonate), carbonate, chloride, clavulanate, citrate, dihydrochloride, edetate, fumarate, gluconate, glutamate, glyconate, hydrabamine, hydrobromine, hydrochloride, iodide, isothionate, lactate, malate, maleate, malonate, mandelate, mesylate, nitrate, oleate, pamoate, palmitate, phosphate/diphosphate, saccharinate, salicylate, stearate, sulfate, succinate, tartrate, tosylate, trichloroacetate, trifluoroacetate and the like.
  • Examples of salt forms of compounds representative of the present invention include the monohydrochloride salt.
  • any of the processes for preparation of the compounds of the present invention it may be necessary and/or desirable to protect sensitive or reactive groups on any of the molecules concerned. This may be achieved by means of conventional protecting groups, such as those described in Protective Groups in Organic Chemistry, ed. J.F.W. McOmie, Plenum Press, 1973; and T.W. Greene & P.G.M. Wuts, Protective Groups in Organic Synthesis, 3 rd Edition, John Wiley & Sons, 1999.
  • the protecting groups may be removed at a convenient subsequent stage using methods known in the art.
  • the scope of the present invention encompasses all such protected compound forms and mixtures thereof.
  • the invention includes compounds of various isomers and mixtures thereof.
  • the term “isomer” refers to compounds that have the same composition and molecular weight but differ in physical and/or chemical properties. Such substances have the same number and kind of atoms but differ in structure. The structural difference may be in constitution (geometric isomers) or in an ability to rotate the plane of polarized light (optical isomers).
  • the term “optical isomer” means isomers of identical constitution that differ only in the spatial arrangement of their groups. Optical isomers rotate the plane of polarized light in different directions.
  • optical activity means the degree to which an optical isomer rotates the plane of polarized light.
  • racemate or “racemic mixture” means an equimolar mixture of two enantiomeric species, wherein each of isolated specie rotates the plane of polarized light in the opposite direction such that the mixture is devoid of optical activity.
  • enantiomer means an isomer having a nonsuperimposable mirror image.
  • diastereomer means stereoisomers that are not enantiomers.
  • chiral means a molecule which, in a given configuration, cannot be superimposed on its mirror image. This is in contrast to achiral molecules which can be superimposed on their mirror images.
  • the two distinct mirror image versions of the chiral molecule are also known as levo (left-handed), abbreviated L, or dextro (right handed), abbreviated D, depending on which way they rotate polarized light.
  • L left-handed
  • D dextro
  • R and S represent the configuration of groups around a stereogenic carbon atom(s).
  • An example of an isolated form of an achiral mixture includes a dextrorotatory enantiomer, wherein the mixture is substantially free of the levorotatory isomer.
  • substantially free means the levorotatory isomer may, in a range, comprise less than 25% of the mixture, less than 10 %, less than 5 %, less than 2 % or less than 1 % of the mixture according to the formula: n / , (mass levorotatory) ⁇ nn
  • an example of an isolated form of an achiral mixture includes a levorotatory enantiomer, wherein the mixture is substantially free of the dextrorotatory isomer.
  • substantially free means the dextrorotatory isomer may, in a range, comprise less than 25% of the mixture, less than 10 %, less than 5 %, less than 2 % or less than 1 % of the mixture according to the formula: n / , (mass dextrorotatory) ⁇ nn
  • geometric isomer means isomers that differ in the orientation of substituent atoms in relationship to a carbon-carbon double bond, to a cycloalkyl ring, or to a bridged bicyclic system.
  • Substituent atoms (other than hydrogen) on each side of a carbon-carbon double bond may be in an E or Z configuration. In the “E” configuration, the substituents are on opposite sides in relationship to the carbon- carbon double bond. In the "Z” configuration, the substituents are oriented on the same side in relationship to the carbon-carbon double bond.
  • Substituent atoms (other than hydrogen) attached to a ring system may be in a cis or trans configuration.
  • the compounds of the invention may be prepared as individual isomers by either isomer-specific synthesis or resolved from an isomeric mixture.
  • Conventional resolution techniques include combining the free base (or free acid) of each isomer of an isomeric pair using an optically active acid (or base) to form an optically active salt (followed by fractional crystallization and regeneration of the free base), forming an ester or amide of each of the isomers of an isomeric pair by reaction with an appropriate chiral auxiliary (followed by fractional crystallization or chromatographic separation and removal of the chiral auxiliary), or separating an isomeric mixture of either an intermediate or a final product using various well known chromatographic methods.
  • compounds of the present invention may have one or more polymorph or amorphous crystalline forms and, as such, are intended to be included in the scope of the invention.
  • some of the compounds may form solvates with water (i.e., hydrates) or common organic solvents (e.g., organic esters such as ethanolate and the like) and, as such, are also intended to be encompassed within the scope of this invention..
  • the compounds of formula (I) are inhibitors of a protein kinase such as EGFR, HER-I, HER-2 and the like, having an IC 50 (50% inhibition concentration) or an EC 50 (50% effective concentration) in a range of about 50 ⁇ M or less, of about 25 ⁇ M or less, of about 15 ⁇ M or less, of about 10 ⁇ M or less, of about 5 ⁇ M or less, of about 1 ⁇ M or less, of about 0.5 ⁇ M or less, of about 0.25 ⁇ M or less or of about 0.1 ⁇ M or less.
  • the present invention includes a compound of formula (I) and forms thereof as a protein kinase inhibitor, wherein the protein kinase is selected from EGFR, HER-I or HER-2.
  • the present invention includes a prodrug form of a compound of formula (I) and forms thereof as a protein kinase inhibitor.
  • the present invention includes a metabolite form of a compound of formula (I) and forms thereof as a protein kinase inhibitor.
  • the present invention includes an isolated form of a compound of formula (I) and forms thereof as a protein kinase inhibitor.
  • the present invention includes a compound of formula (I) or a form thereof, wherein the compound is labeled with a ligand for use as a marker, and wherein the ligand is a radioligand selected from deuterium, tritium and the like.
  • the present invention includes use of a compound of formula (I) and forms thereof as an inhibitor of a protein kinase such as EGFR, HER-I, HER-2 and the like comprising contacting the protein kinase domain or receptor with the compound.
  • the present invention includes the use of a compound of formula (I) and forms thereof as a pharmaceutical composition, medicine or medicament for treating, preventing or ameliorating a kinase mediated disease, disorder or condition.
  • the present invention includes the use of a compound of formula (I) and forms thereof as a medicament.
  • the present invention includes the use of a prodrug of a compound of formula (I) and forms thereof as a pharmaceutical composition, medicine or medicament for treating, preventing or ameliorating a kinase mediated disease, disorder or condition.
  • the present invention includes the use of a prodrug of a compound of formula (I) and forms thereof as a medicament.
  • the present invention is directed to a method for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I) and forms thereof.
  • the method of the present invention further comprises administering to the subject an effective amount of a prodrug of a compound of formula (I) and forms thereof.
  • the method of the present invention further comprises treating, preventing or ameliorating a chronic or acute EGFR, HER-I or HER-2 mediated disease, disorder or condition.
  • the method of the present invention wherein the disease, disorder or condition is associated with increased or unregulated protein kinase activity, expression or signaling and the like in the subject.
  • the method of the present invention further comprises administering to the subject an effective amount of a compound of formula (I) as a pharmaceutical composition, medicine or medicament thereof.
  • the method of the present invention wherein the disease, disorder or condition is an EGFR kinase mediated head or brain cancer in the subject, and wherein the compound penetrates the blood brain barrier.
  • the method of the present invention further comprises treating or ameliorating nerve damage and promoting axon regeneration subsequent to a brain or spinal cord injury in the subject, wherein the compound is an EGFR inhibitor.
  • the method of the present invention further comprises treating, preventing or ameliorating viral infection by an EGFR kinase mediated cytomegalovirus in the subject.
  • chronic or acute protein kinase mediated disease, disorder or condition includes, and is not limited to diseases, disorders or conditions associated with unregulated kinase activity and conditions that accompany such activity.
  • unregulated protein kinase activity, expression or signaling refers to
  • unregulated cell proliferation refers to cell proliferation of one or more subset of cells in a multicellular organism resulting in harm (such as discomfort or decreased life expectancy) to the multicellular organism.
  • Tumor cells which result from unregulated cell proliferation use many mechanisms to enhance their survival and spread and often have high rates of proliferation because growth control signals that keep normal cells in check are defective. Many tumor cells secrete autocrine growth factors that increase proliferation rates or they induce other cells to secrete growth factors that they utilize.
  • a kinase inhibitor may affect one or more aspects of tumor survival mechanisms and thus be therapeutically useful.
  • a kinase inhibitor may not affect one particular tumor survival mechanism but may still be therapeutically useful by affecting tumor survival by an unknown or as yet unelucidated mechanism of action.
  • a compound of formula (I) or a form thereof is useful for treating, preventing or ameliorating diseases, disorders or conditions such as, without limitation, osteoarthritis, rheumatoid arthritis, synovial pannus invasion in arthritis, multiple sclerosis, myasthenia gravis, diabetes mellitus, diabetic angiopathy, diabetic retinopathy, retinal vessel proliferation, inflammatory bowel disease, Crohn's disease, ulcerative colitis, bone diseases, transplant or bone marrow transplant rejection, lupus, chronic pancreatitis, cachexia, septic shock, fibroproliferative and differentiative skin diseases or disorders, central nervous system diseases, neurodegenerative diseases, disorders or conditions related to nerve damage and axon degeneration subsequent to a brain or spinal cord injury, acute or chronic cancer, ocular diseases, viral infections, heart disease, lung or pulmonary diseases or kidney or renal diseases.
  • diseases, disorders or conditions such as, without limitation, osteoarthritis, rheumatoid arthritis, synovial pan
  • Certain diseases, disorders or conditions further include, without limitation, acute or chronic cancer selected from bladder cancer, brain, head or neck cancer, breast cancer, colorectal cancer, endometrial cancer, epidermoid cancer, esophageal cancer, gastric cancer, glioma cancer, lung cancer, ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer, Kaposi's sarcoma, leukemia, lymphoma or papillocarcinoma; and, cancer-associated pathologies selected from abnormal cell proliferation, unregulated cell proliferation, tumor growth, tumor angiopathy, tumor angiogenesis, tumor vascularization or metastatic cancer cell invasion and migration.
  • acute or chronic cancer selected from bladder cancer, brain, head or neck cancer, breast cancer, colorectal cancer, endometrial cancer, epidermoid cancer, esophageal cancer, gastric cancer, glioma cancer, lung cancer, ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer, Kaposi's sarcoma, leukemia,
  • Certain diseases, disorders or conditions further include, without limitation, fibroproliferative and differentiative skin diseases or disorders selected from papilloma formation, psoriasis, dermatitis, eczema, seborrhea or chemotherapy-induced alopecia; central nervous system diseases selected from Alzheimer's disease, Parkinson's disease or depression; ocular diseases selected from macular degeneration, diseases of the cornea or glaucoma; viral infections selected from mycotic infection, autoimmune disease or cytomegalovirus; heart disease selected from atherosclerosis, neointima formation or transplantation-induced vasculopathies such as arterial restenosis; lung or pulmonary diseases selected from allergic-asthma, lung fibrosis, pulmonary fibrosis or chronic obstructive pulmonary disorder; and, kidney or renal diseases selected from acute, subacute or chronic forms of glomerulonephritis or membranoproliferative glomerulonephritis, glomerulosclerosis, congen
  • Certain HERl kinase mediated cancer includes, without limitation, bladder cancer, brain, head or neck cancer, breast cancer, cervical cancer, colorectal cancer, gastric cancer, glioma cancer, endometrial cancer, esophageal cancer, lung cancer, ovarian cancer, pancreatic cancer or renal cell cancer.
  • Certain HER2 kinase mediated cancer includes, without limitation, bladder cancer, brain, head or neck cancer, breast cancer, colorectal cancer, gastric cancer, endometrial cancer, esophageal cancer, lung cancer, ovarian cancer, prostate cancer or renal cell cancer.
  • administering refers to a means for treating, ameliorating or preventing a disease, disorder or syndrome as described herein with a compound of formula (I) or a form thereof, which would obviously be included within the scope of the invention albeit not specifically disclosed for certain of said compounds.
  • Such methods include therapeutically or prophylactically administering an effective amount of compound of formula (I) or a form thereof at different times during the course of a therapy or concurrently in a combination form. Such methods further include administering an effective amount of said compound with one or more agents at different times during the course of a therapy or concurrently in a combination form.
  • prodrug means a compound of formula (I) or a form thereof that is converted in vivo into a functional derivative form that may contribute to therapeutic biological activity, wherein the converted form may be: 1) a relatively active form; 2) a relatively inactive form; 3) a relatively less active form; or, 4) any form which results, directly or indirectly, from such in vivo conversions.
  • Prodrugs are useful when said compound may be either too toxic to administer systemically, absorbed poorly by the digestive tract or broken down by the body before it reaches its target. Conventional procedures for the selection and preparation of suitable prodrug derivatives are described in, for example, "Design of Prodrugs", ed. H. Bundgaard, Elsevier, 1985.
  • metabolite means a prodrug form of a compound of formula (I) or a form thereof converted by in vivo metabolism or a metabolic process to a relatively less active functional derivative of said compound.
  • subject refers to a patient, such as an animal, a mammal or a human, who has been the object of treatment, observation or experiment and is at risk of (or susceptible to) developing a disease or disorder or having a disease or disorder related to unregulated kinase activity.
  • an effective amount refers to that amount of a compound of formula (I) or a form, pharmaceutical composition, medicine or medicament thereof that elicits the biological or medicinal response (such as inhibiting activation of unregulated kinase activity) in a tissue system, animal or human, that is being sought by a researcher, veterinarian, medical doctor, or other clinician, which includes alleviation of the symptoms of the disease or disorder being treated.
  • the effective amount of said compound is from about 0.001 mg/kg/day to about 300 mg/kg/day.
  • composition refers to a product containing a compound of formula (I) or a form thereof, such as a product comprising the specified ingredients in the specified amounts, as well as any product which results, directly or indirectly, from such combinations of the specified ingredients in the specified amounts.
  • the term “medicament” or “medicine” refers to a product containing a compound of formula (I) or a form thereof.
  • the present invention includes use of such a medicament for treating, preventing or ameliorating a chronic or acute kinase mediated disease, disorder or condition.
  • pharmaceutically acceptable refers to molecular entities and compositions that are of sufficient purity and quality for use in the formulation of a pharmaceutical composition, medicine or medicament of the present invention and that, when appropriately administered to an animal or a human, do not produce an adverse, allergic or other untoward reaction. Since both human use (clinical and over-the- counter) and veterinary use are equally included within the scope of the present invention, a pharmaceutically acceptable formulation would include a pharmaceutical composition, medicine or medicament for either human or veterinary use.
  • combination form refers to the use of a combination product comprising a compound of formula (I) or a form, pharmaceutical composition, medicine or medicament thereof and at least one therapeutic agent for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
  • the effective amount of a combination product for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition may be a reduced amount of either or both the compound or therapeutic agent compared to the effective amount of the compound or therapeutic agent otherwise recommended for treating, preventing or ameliorating the disease, disorder or condition. Therefore, it is contemplated that the compound is administered to the subject before, during or after the time the agent is administered.
  • chemotherapeutic agent refers to chemotherapeutic agents used to treat a kinase mediated cancer or antiviral agents used to treat cytomegalovirus.
  • Chemotherapeutic agents include and are not limited to anti-angiogenic agents, antitumor agents, cytotoxic agents, inhibitors of cell proliferation, radiation therapy and the like or a combination thereof.
  • treating, preventing or ameliorating refers, without limitation, to facilitating the eradication of, inhibiting the progression of or promoting stasis of a chronic or acute kinase mediated disease, disorder or condition.
  • the term "radiation therapy” refers to a therapy that comprises exposing the subject in need thereof to radiation.
  • the present invention includes a method for administering a compound of formula (I) or a form, pharmaceutical composition, medicine or medicament thereof in combination with radiation therapy. Procedures for administering such therapy are known to those skilled in the art. The appropriate scheme of radiation therapy will be similar to those already employed in clinical therapies wherein the radiation therapy is used alone or in combination with other chemotherapeutic agents.
  • the present invention includes a pharmaceutical composition comprising an admixture of a compound of formula (I) or a form thereof and one or more pharmaceutically acceptable excipients.
  • the present invention includes a process for making a pharmaceutical composition, medicine or medicament comprising mixing a compound of formula (I) or a form thereof and an optional pharmaceutically acceptable carrier.
  • the present invention includes a pharmaceutical composition, medicine or medicament resulting from the process of mixing a compound of formula (I) or a form thereof and an optional pharmaceutically acceptable carrier.
  • Contemplated processes include both conventional and unconventional pharmaceutical techniques.
  • Said pharmaceutical composition, medicine or medicament may take a wide variety of forms to effectuate mode of administration, wherein the mode includes, and is not limited to, intravenous (both bolus and infusion), oral, nasal, transdermal, topical with or without occlusion, and via injection intraperitoneally, subcutaneously, intramuscularly, intratumorally, intracerebrally or intracranially.
  • the composition, medicine or medicament may be in a dosage unit such as a tablet, pill, capsule, powder, granule, sterile parenteral solution or suspension, metered aerosol or liquid spray, drop, ampoule, auto-injector device or suppository for such administration modes.
  • compositions, medicines or medicaments suitable for oral administration include solid forms such as pills, tablets, caplets, capsules (each including immediate release, timed release and sustained release formulations), granules and powders; and, liquid forms such as solutions, syrups, elixirs, emulsions and suspensions.
  • forms useful for parenteral administration include sterile solutions, emulsions and suspensions.
  • the pharmaceutical composition, medicine or medicament may be presented in a form suitable for once-weekly or once-monthly administration; for example, an insoluble salt of the active compound, such as the decanoate salt, may be adapted to provide a depot preparation for intramuscular injection.
  • the dosage form (tablet, capsule, powder, injection, suppository, teaspoonful and the like) containing the pharmaceutical composition, medicine or medicament contains an effective amount of the active ingredient necessary to be therapeutically or prophylactically effective as described above.
  • the pharmaceutical composition, medicine or medicament may contain from about 0.001 mg to about 5000 mg (preferably, from about 0.001 to about 500 mg) of a compound of formula (I) or a form thereof and may be constituted into any form suitable for the mode of administration selected for a subject in need.
  • An example of a contemplated effective amount for a pharmaceutical composition, medicine or medicament of the present invention may range from about 0.001 mg to about 300 mg/kg of body weight per day. In another example, the range is from about 0.003 to about 100 mg/kg of body weight per day. In another example, the range is from about 0.005 to about 15 mg/kg of body weight per day.
  • the pharmaceutical composition, medicine or medicament may be administered according to a dosage regimen of from about 1 to about 5 times per day.
  • the pharmaceutical composition, medicine or medicament is preferably in the form of a tablet containing, e.g., 0.01, 0.05, 0.1, 0.5, 1.0, 2.5, 5.0, 10.0, 15.0, 25.0, 50.0, 100, 150, 200, 250 and 500 milligrams of a compound of formula (I) or a form thereof for the symptomatic adjustment of the dosage to the patient to be treated.
  • Optimal dosages will vary depending on factors associated with the particular patient being treated (e.g., age, weight, diet and time of administration), the severity of the condition being treated, the particular compound being used, the mode of administration and the strength of the preparation. The use of either daily administration or post-periodic dosing may be employed.
  • a representative compound of formula (I) includes a compound selected from:
  • a representative compound of formula (I) includes a compound selected from:
  • a representative compound of formula (I) includes a compound selected from:
  • a representative compound of formula (I) includes a compound selected from:
  • Representative compounds of the present invention can be synthesized in accordance with the general synthetic schemes described below and are illustrated more particularly in the specific synthetic examples that follow.
  • the general schemes and specific examples are offered by way of illustration; the invention should not be construed as being limited by the chemical reactions and conditions expressed.
  • Compounds of the present invention can also be useful as intermediates for conversion to other compounds representative of the present invention via functional group transformations.
  • DSC analysis was were conducted on a TA Instruments QlOO.
  • the calibration standard was indium.
  • a sample (approximately 2 mg) was placed into a TA DSC pan and weight was recorded.
  • Crimped pans were used for analysis and the samples were heated under nitrogen (50cc/min) at a rate of 10°C/min, up to a final temperature of 25O 0 C.
  • the data were processed using a thermal analyzer (Universal Analyzer 2000, TA Instruments).
  • a mixture of Compound A2 (in a suitable solvent such as DMSO and the like) and a reagent (such as triethylamine and the like) is reacted with a Compound A3 to provide a Compound A4.
  • a mixture of Compound A4 (in a suitable solvent such as DMSO and the like) is reacted with NH 2 OH hydrochloride to provide a Compound A5, representative of a compound of formula (I).
  • a mixture of Compound A5 (in a suitable solvent such as DMF and the like) and a basic reagent (such as cesium carbonate and the like) is reacted with a Compound A6 (wherein Qi is a leaving group such as a halogen atom and the like) to provide a Compound A7, representative of a compound of formula (I).
  • a solution of Compound A7 (in a suitable solvent such as DMF and the like) is reacted with a Compound A8 (wherein Q 2 is a leaving group such as a halogen atom and the like) to provide a Compound A9, representative of a compound of formula (I).
  • the Compound A9 is metabolized to provide a Compound AlO, representative of a compound of formula (I).
  • a solution of Compound Al (in a suitable solvent such as toluene and the like) is reacted with a Compound A12 in a suitable solvent such as THF under suitable conditions to provide a Compound A13.
  • a mixture of Compound A13 (in a suitable solvent such as DMSO and the like) and a reagent (such as triethylamine and the like) is reacted with a Compound A3 to provide a Compound A14.
  • a mixture of Compound Bl (in a suitable solvent such as THF and the like) and a reagent (such as triethylamine and the like) is reacted with a Compound A3 to provide a Compound B2.
  • a mixture of Compound A14 (in a suitable solvent such as a mixture of THF and MeOH and the like) is reacted with a reagent mixture (such as a mixture OfMnO 2 , NaCN, AcOH and the like) to provide a Compound Cl.
  • a suitable solvent such as a mixture of THF and MeOH and the like
  • a reagent mixture such as a mixture OfMnO 2 , NaCN, AcOH and the like
  • a mixture of Compound C2 is reacted with a Compound C3 and a reagent mixture (such as EDCI in DMF and the like) to provide a Compound C4.
  • a reagent mixture such as EDCI in DMF and the like
  • a solution of Compound C4 (in a solvent such as DCM and the like) is reacted with a reagent mixture (such as Et 3 N and toluene sulfonyl chloride and the like) to provide a Compound C5, representative of a compound of formula (I).
  • a reagent mixture such as Et 3 N and toluene sulfonyl chloride and the like
  • NH 3 (g) was blown through a solution of 4,6-dichloro-pyrimidine-5- carbaldehyde Compound Ia (50 g, 282.5 mmol) in toluene (565 mL, 0.5M) for 3 mins using a 12C glass frit, then the mixture was warmed at 60 0 C with stirring for 30 min.
  • NH 3 (g) was blown through the reaction mixture a second time for 3 min and the reaction was heated for 30 mins.
  • NH 3 (g) was blown through the reaction mixture a third time for 3 min and the reaction was heated for a final 20 mins.

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Abstract

The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.

Description

SUBSTITUTED PYRIMIDINE KINASE INHIBITORS
CROSS REFERENCE TO RELATED APPLICATIONS
This present application claims benefit of U.S. Provisional Patent Application Serial No. 60/752633, filed December 21, 2005, which is incorporated herein by reference in its entirety and for all purposes.
FIELD OF THE INVENTION
The present invention is in the area of substituted pyrimidine compounds and forms thereof and methods of preparation and use thereof as kinase inhibitors.
BACKGROUND OF THE INVENTION
In general, protein kinases are the largest set of structurally related phosphoryl transferases, have highly conserved structures and catalytic functions and may be categorized into families by the substrates they phosphorylate (e.g., protein-tyrosine, protein-serine/threonine, histidine and the like) and are responsible for the control of a wide variety of cellular signal transduction processes.
Examples of protein-tyrosine kinases include, but are not limited to, Irk,
IGFR-I, Zap-70, Bmx, Btk, CHK (Csk homologous kinase), CSK (C-terminal Src Kinase), Itk-1, Src (c-Src, Lyn, Fyn, Lck, Syk, Hck, Yes, BIk, Fgr and Frk), Tec, Txk/Rlk, AbI, EGFR (EGFR- 1/ErbB-l, ErbB-2/NEU/HER-2, ErbB-3 and ErbB-4), FAK, FGFlR (also FGFRl or FGR-I), FGF2R (also FGR-2), MET (also Met-1 or c- MET), PDGFR (α and β), Tie-1, Tie-2 (also Tek-1 or Tek), VEGFRI (also FLT-I),
VEGFR2 (also KDR), FLT-3, FLT- 4, c-KIT, JAKl, JAK2, JAK3, TYK2, LOK, RET, TRKA, PYK2, ALK (Anaplastic Lymphoma Kinase), EPHA (1-8), EPHB (1-6), RON, Fes, Fer or EPHB4 (also EPHB4-1).
Examples of protein-serine/threonine kinases include, but are not limited to, Ark, ATM (1-3), CamK (I-IV), CamKK, Chkl and 2 (Checkpoint kinases), CKI, CK2, Erk, IKK- 1 (also IKK-ALPHA or CHUK), IKK-2 (also IKK-BETA), Ilk, Jnk (1-3), LimK (1 and 2), MLK3Raf (A, B, and C), CDK (1-10), PKC (including all PKC subtypes), PIk (1-3), NIK, Pak (1-3), PDKl, PKR, RhoK, RIP, RIP-2, GSK3 (α and β), PKA, P38, Erk (1-3), PKB (including all PKB subtypes) (also AKT-I, AKT-2, AKT-3 or AKT3-1), IRAKI, FRK, SGK, TAKl or Tpl-2 (also COT).
Protein kinases play very important roles in the normal regulation of cell growth. However, as a result of dysregulation of the tyrosine kinases (receptor or non- receptor) or the ligands of the receptor tyrosine kinases, signaling can become deregulated, resulting in uncontrolled cell proliferation leading to cancer or a related disease, disorder or syndrome.
Protein kinases catalyze and regulate the process of phosphorylation, whereby the kinases covalently attach phosphate groups to proteins or lipid targets in response to a variety of extracellular signals: hormones, neurotransmitters, growth and differentiation factors, cell cycle events, environmental stresses, nutritional stresses and the like.
Phosphorylation modulates or regulates a variety of cellular processes such as proliferation, growth, differentiation, metabolism, apoptosis, motility, transcription, translation and other signaling processes. Defective control of protein phosphorylation due to unregulated cellular mitosis, unregulated cell proliferation and upregulated kinase activity has been implicated in a number of diseases and disease conditions, such as osteoarthritis, rheumatoid arthritis, synovial pannus invasion in arthritis, multiple sclerosis, myasthenia gravis, diabetes mellitus, diabetic angiopathy, diabetic retinopathy, retinal vessel proliferation, inflammatory bowel disease, Crohn's disease, ulcerative colitis, bone diseases, transplant or bone marrow transplant rejection, lupus, chronic pancreatitis, cachexia, septic shock, fϊbroproliferative and differentiative skin diseases or disorders, central nervous system diseases, neurodegenerative diseases, disorders or conditions related to nerve damage and axon degeneration subsequent to a brain or spinal cord injury, acute or chronic cancer, ocular diseases, viral infections, heart disease, lung or pulmonary diseases or kidney or renal diseases. Therefore, kinase inhibitors have potential use as therapeutic agents.
The term "myasthenia gravis" means a disease having the characteristic feature of easy fatigue of certain voluntary muscle groups on repeated use. Muscles of the face or upper trunk are especially likely to be affected. In most and perhaps all cases, the disease is due to the development of autoantibodies against the acetylcholine receptor in neuromuscular junctions. Immunization of animals with this receptor protein leads to a disease with the features of myasthenia gravis.
In reference to "synovial pannus invasion in arthritis," the term "pannus" means a disease whereby vascularised granulation tissue rich in fibroblasts, lymphocytes and macrophages, derived from synovial tissue, overgrows the bearing surface of the joint in rheumatoid arthritis and is associated with the breakdown of the articular surface.
The tyrosine kinases can further be categorized by whether they are receptor tyrosine kinases or non-receptor tyrosine kinases. The receptor tyrosine kinases span the cell membrane with a ligand interacting domain protruding from the cell, with a hydrophobic trans-membrane domain, and a cytoplasmic domain that contains the catalytic kinase domain and other regulatory sequences. Non-receptor tyrosine kinases are often myristylated or modified by the addition of other hydrophobic moieties that allow them to be anchored to the cell membrane.
The epidermal growth factor receptor (EGFR) tyrosine-kinase family includes the receptors EGFR (also referred to as EGFR-I or Erb-Bl), HER-2 (or neu), EGFR3 and EGFR4. Epidermal Growth Factor (EGF), Transforming Growth Factor-α (TGF- α) and the HER-2 ligand heregulin are three of the ligands that bind to the EGFR receptors.
For example, EGFR overexpression or mutation of one or more EGFR kinase family members has been commonly involved in cancer and other diseases characterized by uncontrolled or abnormal cell growth. Deregulation of EGFR has also been associated with epidermoid tumors, head and neck tumors, breast tumors and tumors involving other major organs, such as the lungs and gastrointestinal tract. The clinically prevalent cancers related to EGFR include lung, gastric and head and neck cancer (Klijn JG, Berns PM, Schmitz PI and Foekens JA; The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients, Endocr. Rev., 1992, 13, 3-17; Salomon D and Gullick W; The erbB family of receptors and their ligands: Multiple targets for therapy, Signal, 2001, 2, 4-11). In treating cancers of the head such as brain cancers and the like, the ability of small molecule EGFR inhibitors to penetrate the blood brain barrier could have therapeutic advantages since EGFR is often overexpressed in primary brain tumors and also in breast and non-small cell lung carcinomas that frequently metastasize to the brain (Eckstrand AJ, Sugawa N, James CD and Collins VP; Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N-and/or C-terminal tails, Proc. Acad. Natl. Sci. USA, 1992, 89, 4309-4313; and, Wickstrand CJ, Hale LP, Batra SK, Hill ML, Humphrey PA, Kurpad SN, McLendon RE, Moscatello D, Pegram CN, Reist CJ, Traweek ST, Wong AJ, Zalutsky MR and Bigner, DD; Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas, Cancer Res., 1995, 55, 3140-3148).
Diseases associated with increased EGFR expression include proliferative glomerulonephritis, diabetes-induced renal disease and chronic pancreatitis.
EGFR inhibitors tested in neurite outgrowth assays have activity in promoting neurite outgrowth in both cerebellar granule cells and dorsal root ganglion neurons, likely by acting directly on neurons to block neuronal inhibitory responses to myelin inhibitors, and thus an EGFR inhibitor may have potential use for promoting axon regeneration after brain and spinal cord injury (V. Koprivica, et al, EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans, Science, 2005, 310, 106).
HERl and HER2 overexpression has been implicated in a variety of cancers, such as bladder, breast, colorectal, endometrial, esophageal, gastric(stomach), glioma head and neck, lung (non-small cell lung cancer), ovarian, pancreatic, renal and prostate cancer.
Comparing the overexpression of HERl and HER2 in tumors, according to order of prevalence, HERl overexpression is found in breast, renal cell, lung, colorectal, head and neck, ovarian, pancreatic, glioma, bladder, esophageal, gastric, endometrial and cervical cancer tumors; in contrast, HER2 overexpression is found in esophageal, head and neck, lung, gastric, renal cell, breast, bladder, ovarian and colorectal, prostate and endometrial cancer tumors (Horizons in Cancer Therapeutics: From Bench to Bedside, Signal Transduction Inhibitors, 2001, 2(2), ISSN 1532-3048).
While the degree of HER2 overexpression in breast and ovarian cancer is not as great as in some other cancers, HER2 has been found to be responsible for these clinically prevalent cancers (Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A and McGuire WL; Human breast cancer: Correlation of relapse and survival with amplification of HER-2/neu oncogene, Science, 1987, 235, 177-82; Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, et al; Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer, Science, 1989, 244, 707-712; Hetzel DJ, Wilson TO, Keeney GL, Roche PC, Cha SS and Podrantz KC; HER-2/neu expression: A major prognostic factor in endometrial cancer, Gynecol. Oncol, 1992, 47, 179-85).
Furthermore, patients with HER-2 overexpressing breast cancer frequently experience metastases to the brain (Kirsch DG and Hochberg FH; Targeting HER-2 in brain metastases from breast cancer, Clin. Can. Res., 2003, 9, 5435-5436). These patients have an extremely poor prognosis and intracerebral tumors are often the cause of death. Autopsy revealed that 20-30% of patients who die of breast cancer have brain metastases (Grossi PM, Ochiai H, Archer GE, McLendon RE, Zalutsky MR, Friedman AH, Friedman HS, Bigner DD and Sampson JH; Efficacy of intracerebral microinfusion of trastuzumab in an athymic rat model of intracerebral metastatic breast cancer, Clin. Can. Res., 2003, 9, 5514-5520).
Human cytomegalovirus (CMV) is a widespread opportunistic human herpes virus that causes severe and fatal diseases in those who are immune compromised and in transplant recipients. CMV is also a leading cause of atherosclerosis and virally mediated birth defects. The human CMV uses the EGFR receptor to enter cells during infection, EGFR is autophosphorylated and the downstream signal transduction pathway components are activated; however, the EGFR specific inhibitor tyrphostin AG 1478 has been shown to reduce the viral load in cells that were infected in the presence of the tyrphostin (Wang X, et al., Nature, 24 July 2003, Vol. 424, 456-461). Accordingly, potent EGFR selective inhibitors may be useful in anti-CMV therapy. Certain oxime substituted pyrimidines are registered by the Chemical Abstracts Society (CAS) such as 4,6-diamino-5-pyrimidinecarboxaldehyde oxime (CAS Registry No. : 109831 -69-8) and N,N'-dimethyl-5-[(methylimino)methyl]-4,6-pyrimidinediamine (CAS Registry No.: 14160-97-5) and described in Heterocycles, 1987, 25(1), 343-5. Certain references describe substituted pyrimidine compounds such as United States Patents: US 6,080,750, US 6,107,301 and US 6,833,378.
There is a need for potent small-molecule kinase inhibitors of one or more of the EGFR, HER-I, HER-2 kinase proteins and the like possessing anti-tumor cell proliferation activity, and as such are useful for treating or ameliorating a EGFR, HER- 1 or HER-2 kinase receptor mediated, angiogenesis-mediated or hyperproliferative disorder.
SUMMARY OF THE INVENTION
The present invention is directed to a compound of formula (I):
Figure imgf000007_0001
and forms thereof, wherein RA, R2, R3, R4, R5, Re, R7, L and Ar are as defined herein. An example of the present invention includes a compound of formula (I) and forms thereof as a protein kinase inhibitor.
An example of the present invention includes a prodrug form of a compound of formula (I) and forms thereof as a protein kinase inhibitor.
An example of the present invention includes a metabolite form of a compound of formula (I) and forms thereof as a protein kinase inhibitor.
An example of the present invention includes use of a compound of formula (I) and forms thereof as an inhibitor of a protein kinase such as EGFR, HER-I, HER-2 and the like comprising contacting the protein kinase domain or receptor with the compound.
An example of the present invention includes the use of a compound of formula (I) and forms thereof as a pharmaceutical composition, medicine or medicament for treating, preventing or ameliorating a kinase mediated disease, disorder or condition.
An example of the present invention includes the use of a compound of formula (I) and forms thereof as a medicament.
An example of the present invention includes the use of a prodrug of a compound of formula (I) and forms thereof as a pharmaceutical composition, medicine or medicament for treating, preventing or ameliorating a kinase mediated disease, disorder or condition.
An example of the present invention includes the use of a prodrug of a compound of formula (I) and forms thereof as a medicament.
The present invention is further directed to a method for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I) and forms thereof.
An example of the present invention includes a method for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition in a subject in need thereof comprising administering to the subject an effective amount of a prodrug of a compound of formula (I) and forms thereof.
These and other aspects and advantages of the invention, which will become apparent in light of the detailed description below, are achieved through use of the compounds of this invention.
DETAILED DESCRIPTION OF THE INVENTION
The present invention is directed to a compound of formula (I):
Figure imgf000009_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl; Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-
C3-12cycloalkyl;
RA is selected from C=N-O-Ri, cyano or an Ri substituted oxadiazole; Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl,
Ci_galkyl-sulfonyl-Ci_galkyl, Ci_galkyl-sulfonyloxy-Ci_galkyl, aryl, aryl-Ci_8alkyl, aryloxy-Ci_8alkyl, heterocyclyl-Ci_8alkyl, heterocyclyl-carbonyl-Ci_8alkyl, benzofused-heterocyclyl-Ci.galkyl or heteroaryl-Ci_8alkyl, wherein aryl-Ci_8alkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino,
Ci_8alkyl-amino or Ci_galkoxycarbonyl, and wherein heterocyclyl-Ci.galkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl;
R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and
R3, R4, R5, Re and R7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl,
Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_8alkyl, Ci_galkyl-amino-Ci_galkyl,
Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_galkoxy, wherein aryl, aryloxy, aryl-amino, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_galkyl, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, carboxy, Ci_gacyl or Ci_galkoxycarbonyl.
The present invention is directed to a compound of formula (II):
Figure imgf000010_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl; Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-
C3_i2cycloalkyl, wherein the benzene ring portion of the benzo fused ring system is attached to the L variable;
RA is selected from C=N-O-Ri or cyano; Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl, Ci_galkyl-sulfonyl-Ci_galkyl, Ci_galkyl-sulfonyloxy-Ci_galkyl, aryl, aryl-Ci_8alkyl, aryloxy-Ci_8alkyl, heterocyclyl-Ci_8alkyl, heterocyclyl-carbonyl-Ci_galkyl or heteroaryl-Ci_galkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl, and wherein heterocyclyl-Ci_galkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl;
R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and
R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl,
Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, amino, Ci_galkyl-amino, amino-Ci_galkyl,
Ci_galkyl-amino-Ci_galkyl, carboxy, Ci_gacyl, Ci_galkoxycarbonyl, C3-i2cycloalkyl, aryl, aryloxy, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy or heterocyclyl, wherein aryl, aryloxy, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl or Ci_galkoxycarbonyl, and wherein heteroaryl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_galkyl, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, carboxy, Ci_gacyl or
Ci-galkoxycarbonyl. An example of a compound of formula (I) and forms thereof includes a compound wherein RA is C=N-O-Ri.
An example of a compound of formula (I) and forms thereof includes a compound wherein RA is cyano.
An example of a compound of formula (I) and forms thereof includes a compound wherein RA is an Ri substituted oxadiazole.
An example of a compound of formula (I) and forms thereof includes a compound wherein Ri is selected from hydrogen, Ci_8alkyl, Ci_galkenyl, Ci_galkoxy, Ci_8alkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl,
Ci_galkyl-sulfonyl-Ci_galkyl, Ci_galkyl-sulfonyloxy-Ci_galkyl, aryl, aryl-Ci_galkyl, aryloxy-Ci.galkyl, heterocyclyl-Ci_galkyl, heterocyclyl-carbonyl-Ci-galkyl, benzofused- heterocyclyl-Ci_8alkyl or heteroaryl-Ci_8alkyl, wherein aryl-Ci_8alkyl is optionally substituted on aryl with a substituent selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_8alkyl-amino or Ci_galkoxycarbonyl, and wherein heterocyclyl-Ci_galkyl is optionally substituted on heterocyclyl with a substituent selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino,
Ci_galkyl-amino or Ci_galkoxycarbonyl.
An example of a compound of formula (I) and forms thereof includes a compound wherein Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci_galkoxy-Ci_galkyl-amino-Ci_galkyl, Ci_galkyl-sulfonyl-Ci_galkyl, Ci_galkyl-sulfonyloxy-Ci_galkyl, aryl, aryl-Ci_galkyl, aryloxy-Ci_galkyl, heterocyclyl-Ci.galkyl, heterocyclyl-carbonyl-Ci_galkyl, benzofused- heterocyclyl-Ci_galkyl or heteroaryl-Ci_galkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with Ci_galkoxy, and wherein heterocyclyl-Ci_galkyl is optionally substituted on heterocyclyl with hydroxy or Ci_galkoxycarbonyl. An example of a compound of formula (I) and forms thereof includes a compound wherein Ri is selected from hydrogen, Ci_8alkyl, Ci-salkenyl, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci-salkyl, hydroxy-Ci-salkoxy, Ci_8alkyl-amino-Ci_8alkyl, Ci-salkoxy-Ci-salkyl-amino-Ci-galkyl, Ci.galkyl-sulfonyloxy-Ci.galkyl, aryl, aryl-Ci_galkyl, aryloxy-Ci_galkyl, heterocyclyl-Ci.galkyl, heterocyclyl-carbonyl-Ci.galkyl, benzofused- heterocyclyl-Ci.galkyl or heteroaryl-Ci_galkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with Ci_galkoxy, and wherein heterocyclyl-Ci_galkyl is optionally substituted on heterocyclyl with hydroxy or Ci_galkoxycarbonyl.
An example of a compound of formula (I) and forms thereof includes a compound wherein R2 is selected from hydrogen.
An example of a compound of formula (I) and forms thereof includes a compound wherein R2 is selected from Ci_galkyl.
An example of a compound of formula (I) and forms thereof includes a compound wherein R2 is selected from Ci_galkoxy.
An example of a compound of formula (I) and forms thereof includes a compound wherein R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci-galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_8acyl-amino, Ci_8alkoxycarbonyl, thio-Ci_8alkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl, aryl-Ci_8alkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci-salkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_galkoxy substituents, wherein aryl, aryl-amino, aryl-Ci_8alkyl and aryl-Ci_8alkoxy is each optionally substituted on aryl with one or two substituents each selected from cyano, halogen, hydroxy, Ci_8alkyl, Ci_galkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with two oxo substituents, and wherein heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one or two substituents each selected from Ci_8alkyl, amino-Ci-galkyl, Ci_galkyl-amino-Ci_galkyl, carboxy, Ci_gacyl or Ci-galkoxycarbonyl.
An example of a compound of formula (I) and forms thereof includes a compound wherein R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci-galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3-i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_galkoxy substituents, wherein aryl, aryl-amino, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one or two substituents each selected from cyano, halogen, Ci_galkoxy or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with two oxo substituents, and wherein heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one or two Ci_galkyl substituents.
An example of a compound of formula (I) and forms thereof includes a compound wherein R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, halo-Ci_galkyl, halo-Ci_galkoxy, cyano-Ci_galkyl, Ci_galkyl-amino, Ci-galkyl-amino-Ci-galkyl-amino-carbonyl, Ci_8alkoxy-imino-Ci_8alkyl, Ci_8alkoxy-imino-(aryl)Ci_8alkyl, C1-8acyl, Ci_8acyl-amino, Ci_8alkoxycarbonyl, thio-Ci_8alkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl, aryl-Ci_salkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_salkoxy substituents, wherein aryl, aryl-amino, aryl-Ci_8alkyl and aryl-Ci_salkoxy is each optionally substituted on aryl with one or two substituents each selected from cyano, halogen, Ci_8alkoxy or Ci_salkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with two oxo substituents, and wherein heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one or two Ci_galkyl substituents.
An example of a compound of formula (I) and forms thereof includes a compound wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl; Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-
C3-12cycloalkyl; RA is selected from C=N-O-Ri, cyano or an Ri substituted oxadiazole;
Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_8alkyl, hydroxy-Ci_8alkoxy, Ci_8alkyl-amino-Ci_8alkyl, Ci-salkoxy-Ci-salkyl-amino-Ci-salkyl, Ci_8alkyl-sulfonyloxy-Ci_8alkyl, aryl, aryl-Ci.galkyl, aryloxy-Ci_galkyl, heterocyclyl-Ci.galkyl, heterocyclyl-carbonyl-Ci.galkyl, benzofused-heterocyclyl-Ci.galkyl or heteroaryl-Ci_galkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with Ci_galkoxy, and wherein heterocyclyl-Ci_galkyl is optionally substituted on heterocyclyl with hydroxy or Ci_galkoxycarbonyl; R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and
R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl,
Ci.galkoxy, halo-Ci_galkyl, halo-Ci_galkoxy, cyano-Ci_galkyl, Ci_galkyl-amino, Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci.galkoxy-imino-Ci.galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused- heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_galkoxy substituents, wherein aryl, aryl-amino, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one or two substituents each selected from cyano, halogen, Ci_galkoxy or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with two oxo substituents, and wherein heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one or two Ci_galkyl substituents.
An example of a compound of formula (I) and forms thereof includes a compound wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl;
Ar is selected from phenyl, naphthalenyl, 1,2,3,4-tetrahydro-naphthalenyl, 5,6,7,8- tetrahydro-naphthalenyl, pyridinyl, pyridiminyl, indazolyl, indolyl, benzofuranyl, benzoimidazolyl, benzothiazolyl, benzo[l,3]dioxolyl, 2,3- dihydro-indolyl, 1,2,3,4-tetrahydro-phthalazinyl or indanyl;
RA is selected from C=N-O-Ri, cyano or an Ri substituted oxadiazole;
Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, Ci_galkyl-amino-Ci_galkyl,
Ci-galkoxy-Ci-galkyl-amino-Ci-galkyl, Ci_galkyl-sulfonyloxy-Ci_galkyl, aryl, phenyl-Ci_8alkyl, phenoxy-Ci_8alkyl, morpholin-4-yl-Ci_8alkyl, piperidinyl-Ci_8alkyl, morpholin-4-yl-carbonyl-Ci_8alkyl, benzofused- heterocyclyl-Ci_8alkyl or pyridinyl-Ci_8alkyl, wherein phenyl-Ci_salkyl is optionally substituted on phenyl with Ci_8alkoxy, and wherein piperidinyl-Ci.galkyl is optionally substituted on piperidinyl with hydroxy or Ci.galkoxycarbonyl; R2 is selected from hydrogen, Ci.galkyl or Ci.galkoxy; and
R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl,
Ci_8alkoxy, halo-Ci_8alkyl, halo-Ci_8alkoxy, cyano-Ci_salkyl, Ci_8alkyl-amino, Ci-salkyl-amino-Ci-salkyl-amino-carbonyl, Ci_8alkoxy-imino-Ci_8alkyl, Ci_8alkoxy-imino-(aryl)Ci_8alkyl, Ci_sacyl, Ci.gacyl-amino, Ci_galkoxycarbonyl, thio-Ci.galkyl, substituted phosphonic acid, cyclohexyl, phenyl, phenoxy, phenyl-amino, phenyl-Ci_galkyl, phenyl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, phenyl-amido, pyridinyloxy, heteroaryl-Ci_galkoxy, pyridimin-2- yl-amino-sulfonyl, pyrazin-2-yl-amino-sulfonyl, benzofused-heterocyclyl or morpholin-4-yl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_galkoxy substituents, wherein phenyl, phenyl-amino, phenyl-Ci_galkyl and phenyl-Ci_galkoxy is each optionally substituted on aryl with one or two substituents each selected from cyano, halogen, Ci_galkoxy or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with two oxo substituents, and wherein pyridimin-2-yl-amino-sulfonyl, pyrazin-2-yl-amino-sulfonyl and pyridinyloxy is each optionally substituted with one or two Ci_galkyl substituents.
An example of a compound of formula (I) and forms thereof includes a compound wherein
L is a bond;
Ar is selected from phenyl, 1,2,3,4-tetrahydro-naphthalenyl, pyridinyl, indazolyl or indolyl; RA is selected from C=N-O-Ri or cyano;
Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, hydroxy-Ci_galkyl, morpholin-4- yl-Ci_8alkyl or piperidinyl-Ci_8alkyl;
R2 is hydrogen; and
R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, phenoxy, phenyl-Ci_8alkyl or phenyl-Ci-salkoxy, wherein phenyl-Ci_galkyl is optionally substituted on phenyl with halogen. The present invention is further directed to a compound of formula (Ia):
Figure imgf000018_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl;
Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl,
Ci.galkyl-amino-Ci.galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl,
Ci_galkyl-sulfonyl-Ci_galkyl, Ci_galkyl-sulfonyloxy-Ci_galkyl, aryl, aryl-Ci_galkyl, aryloxy-Ci_galkyl, heterocyclyl-Ci_galkyl, heterocyclyl-carbonyl-Ci_8alkyl, benzofused-heterocyclyl-Ci_8alkyl or heteroaryl-Ci_8alkyl, wherein aryl-Ci_8alkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci_galkyl, Ci-salkoxy, amino,
Ci.galkyl-amino or Ci_galkoxycarbonyl, and wherein heterocyclyl-Ci-salkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_galkyl, Ci.galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl; R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl,
Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl,
Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_8alkoxy-imino-(aryl)Ci_8alkyl, carboxy, C1-8acyl, Ci_8acyl-amino, Ci_8alkoxycarbonyl, thio-Ci_8alkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl, aryl-Ci_salkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_salkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci-salkyl, Ci-salkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_salkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from C1-8alkyl, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, carboxy, Ci_8acyl or Ci-salkoxycarbonyl.
The present invention is further directed to a compound of formula (Ib):
Figure imgf000019_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl; -X-Y-Z- is a moiety selected from -N(R3)-N=C(R3)-, =N-N(R3)-C(R3)=,
-N(R3)-C(R3)=C(R3)-, -C(R3)2-C(R3)2-C(R3)2-, -O-C(R3)2-O-, -N(R3)-C(R3)=N-, -O-C(R3)=C(R3)-, -N(R3)-C(R3)2-C(R3)2- or -S-C(R3)=N-; wherein the dashed lines in formula (Ib) represent the locations for one or two double bonds when present in the moiety;
Ri is selected from hydrogen, Ci_8alkyl, Ci_8alkenyl, Ci_8alkoxy, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl, Ci_8alkyl-sulfonyl-Ci_8alkyl, Ci_8alkyl-sulfonyloxy-Ci_8alkyl, aryl, aryl-Ci_8alkyl, aryloxy-Ci_8alkyl, heterocyclyl-Ci-salkyl, heterocyclyl-carbonyl-Ci_8alkyl, benzofused-heterocyclyl-Ci-salkyl or heteroaryl-Ci_8alkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci.galkyl, Ci.galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl, and wherein heterocyclyl-Ci_galkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_8alkyl, Ci.galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl; R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and R3 is selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy,
Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_8acyl-amino, Ci_8alkoxycarbonyl, thio-Ci_8alkyl, substituted phosphonic acid,
C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl, aryl-Ci_8alkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_8alkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci-salkyl, Ci-salkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci-salkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci.galkyl, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, carboxy, Ci_8acyl or Ci_8alkoxycarbonyl.
The present invention is further directed to a compound of formula (Ic):
Figure imgf000021_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl;
Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused- C3-i2cycloalkyl;
R2 is selected from hydrogen, Ci.galkyl or Ci_galkoxy; and
R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci_8alkoxy, Ci_8alkoxy-Ci_salkyl, hydroxy-Ci_8alkyl, halo-Ci_salkyl, hydroxy-Ci_8alkoxy, halo-Ci_salkoxy, cyano-Ci_8alkyl, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl,
Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_8alkoxy-imino-Ci_8alkyl, Ci_8alkoxy-imino-(aryl)Ci_8alkyl, carboxy, Ci_sacyl, Ci_gacyl-amino, Ci.galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3-i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl, aryl-Ci_8alkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_galkoxy, wherein aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl and aryl-Ci_8alkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_galkyl, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, carboxy, Ci.gacyl or Ci-galkoxycarbonyl.
An example of a compound of formula (Ic) and forms thereof includes a compound wherein R2 is selected from hydrogen.
An example of a compound of formula (Ic) and forms thereof includes a compound wherein R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci_galkoxy, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_8alkyl, halo-Ci_8alkyl, hydroxy-Ci_8alkoxy, halo-Ci_8alkoxy, cyano-Ci_8alkyl, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, Ci-galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_8alkoxy-imino-Ci_8alkyl, Ci_8alkoxy-imino-(aryl)Ci_8alkyl, carboxy, Ci_8acyl, Ci.sacyl-amino, Ci_salkoxycarbonyl, thio-Ci_salkyl, substituted phosphonic acid, C3-i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_galkoxy substituents, wherein aryl, aryl-amino, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one or two substituents each selected from cyano, halogen, hydroxy, Ci_8alkyl, Ci.galkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci-salkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with two oxo substituents, and wherein heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one or two Ci-salkyl substituents.
An example of a compound of formula (Ic) and forms thereof includes a compound wherein R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci.galkyl, Ci.galkoxy, Ci.galkoxy-Ci.galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci-galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_galkoxy substituents, wherein aryl, aryl-amino, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one or two substituents each selected from cyano, halogen, Ci_galkoxy or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with two oxo substituents, and wherein heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one or two Ci_galkyl substituents.
An example of a compound of formula (Ic) and forms thereof includes a compound wherein R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci.galkoxy, halo-Ci_8alkyl, halo-Ci_8alkoxy, cyano-Ci_8alkyl, Ci_8alkyl-amino, Ci-salkyl-amino-Ci-salkyl-amino-carbonyl, Ci_8alkoxy-imino-Ci_8alkyl, Ci_8alkoxy-imino-(aryl)Ci_8alkyl, Ci_sacyl, Ci_8acyl-amino, Ci_8alkoxycarbonyl, thio-Ci_salkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_galkoxy substituents, wherein aryl, aryl-amino, aryl-Ci_8alkyl and aryl-Ci_8alkoxy is each optionally substituted on aryl with one or two substituents each selected from cyano, halogen, Ci_galkoxy or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with two oxo substituents, and wherein heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one or two Ci_galkyl substituents.
An example of a compound of formula (Ic) and forms thereof includes a compound wherein L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl;
Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-
C3-i2cycloalkyl;
R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and
R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, halo-Ci_galkyl, halo-Ci_galkoxy, cyano-Ci_galkyl, Ci_galkyl-amino,
Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused- heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two Ci_galkoxy substituents, wherein aryl, aryl-amino, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one or two substituents each selected from cyano, halogen, Ci_galkoxy or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with two oxo substituents, and wherein heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one or two Ci_galkyl substituents.
The present invention is further directed to a compound of formula (Id):
Figure imgf000025_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl; R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and
R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci_8alkoxy, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_salkyl, halo-Ci_8alkyl, hydroxy-Ci_8alkoxy, halo-Ci_salkoxy, cyano-Ci_8alkyl, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl,
Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_8alkoxy-imino-Ci_8alkyl,
Ci_8alkoxy-imino-(aryl)Ci_8alkyl, carboxy, Ci_sacyl, Ci_gacyl-amino, Ci.galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3-i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_galkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_8alkyl, Ci_galkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_galkyl, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, carboxy, Ci.gacyl or Ci_galkoxycarbonyl.
The present invention is further directed to a compound of formula (Ie):
Figure imgf000026_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl;
-X-Y-Z- is a moiety selected from -N(R3)-N=C(R3)-, =N-N(R3)-C(R3)=,
-N(R3)-C(R3)=C(R3)-, -C(R3)2-C(R3)2-C(R3)2-, -O-C(R3)2-O-, -N(R3)-C(R3)=N-, -O-C(R3)=C(R3)-, -N(R3)-C(R3)2-C(R3)2- or -S-C(R3)=N-; wherein the dashed lines in formula (Ie) represent the locations for one or two double bonds when present in the moiety;
R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and
R3 is selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy,
Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl,
Ci_galkyl-amino-Ci_galkyl, Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3-12cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl, aryl-Ci_8alkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_galkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_8alkyl and aryl-Ci_8alkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_8alkyl, Ci_galkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_8alkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_salkyl, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, carboxy,
Ci.gacyl or Ci_galkoxycarbonyl.
The present invention is further directed to a compound of formula (If):
Figure imgf000027_0001
and forms thereof, wherein
Xi and X2 is each selected from -C(Re)- or -N-, wherein Xi and X2 are not the same; L is selected from a bond, C^alkyl or halo-Ci_6alkyl;
Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl, Ci_8alkyl-sulfonyl-Ci_8alkyl, Ci_8alkyl-sulfonyloxy-Ci_8alkyl, aryl, aryl-Ci_8alkyl, aryloxy-Ci_8alkyl, heterocyclyl-Ci_8alkyl, heterocyclyl-carbonyl-Ci_8alkyl, benzofused-heterocyclyl-Ci-salkyl or heteroaryl-Ci_8alkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci.galkyl, Ci.galkoxy, amino,
Ci_8alkyl-amino or Ci-salkoxycarbonyl, and wherein heterocyclyl-Ci-salkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_8alkyl, Ci.galkoxy, amino, Ci_8alkyl-amino or Ci-salkoxycarbonyl;
R2 is selected from hydrogen, Ci-salkyl or Ci-salkoxy; and
R3, R4, and R5 is each selected from hydrogen, halogen, hydroxy, Ci-salkyl, Ci-salkoxy,
Ci_8alkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkyl-amino-Ci.galkyl-amino-carbonyl,
Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl,
Ci_8acyl-amino, Ci_8alkoxycarbonyl, thio-Ci_8alkyl, substituted phosphonic acid,
C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl, aryl-Ci_8alkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_salkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_8alkyl and aryl-Ci_salkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci-salkyl, Ci-salkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_salkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_galkyl, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, carboxy, Ci_8acyl or Ci_galkoxycarbonyl; and R6 is selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy,
Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_galkyl, halo-Ci_8alkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl or
Ci_galkyl-amino-Ci_galkyl.
An example of a compound of Formula (I) includes a compound and forms thereof, wherein (*)-RA, R2, R3, R4, R5, Re, R7, L and Ar are dependently selected from (wherein * represents the configuration of the oxime portion in relationship to the double bond; further, when one or more of R3, R4, R5, R6 or R7 is hydrogen, the hydrogen is omitted from the following table): Cpd (*)-RA R2 L (R3-R4-R5-Re-R7)Ar
1 (£>CH=N-OCH3 H bond (3-Cl-4-F)phenyl
2 (£>CH=N-OCH3 H bond 1 -(3-F-benzyl)indazol-5-yl
3 (£>CH=N-OCH3 H bond (3-Cl-4-F)benzyl
4 (£>CH=N-OCH3 H bond [3-Cl-4-(3-F-benzyloxy)]phenyl
5 (£>CH=N-OCH3 H bond 2-(3-F-benzyl)indazol-5-yl
6 (£)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl OCH2C(O)- morpholin-4-yl
7 (£)-CH=N-OCH3 H bond (3-OCH3-4-phenoxy)phenyl
8 (E)-CH=N- H bond (3-OCH3-4-phenoxy)phenyl OCH2C(O)- morpholin-4-yl
9 (£)-CH=N-OCH3 H bond (3-Cl-4-benzyloxy)phenyl
10 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl OCH2CH3
11 (£)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl OCH2CH=CH2
12 (£)-CH=N-0- H bond 1 -(3-F-benzyl)indazol-5-yl C(CH3)3
13 (£)-CH=N-0CH3 H bond (3-CH3-4-pyridin-3- yloxy)phenyl
14 (E)-CH=N- H -CH(R- phenyl OCH2CH3 CH3)-
15 (Z)-CH=N-OH H bond 1 -(3-F-benzyl)indazol-5-yl Cpd (*)-RA R2 L (R3-R4-R5-R6-R7)Ar
16 (E)-CH=N- H -CH(S- phenyl OCH2CH3 CH3)-
17 (E)-CH=N- H bond indol-5-yl OCH2CH3
18 (E)-CH=N- H bond [3-Cl-4-(3-F-benzyloxy)]phenyl OCH2CH3
19 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl O(CH2)2- morpholin-4-yl
20 (E)-CH=N-OCH3 H bond indan-5-yl
21 (E)-CH=N-OCH3 H bond 4-OCHF2-phenyl
22 (E)-CH=N-OCH3 H bond indazol-5-yl
23 (E)-CH=N-OCH3 H bond benzo[l,3]dioxol-5-yl
24 (E)-CH=N-OCH3 H bond (4-phenoxy)phenyl
25 (E)-CH=N-OCH3 H bond (4-benzyloxy)phenyl
26 (E)-CH=N-OCH3 H bond 4-CH(CH3)CH2CH3-phenyl
27 (E)-CH=N-OCH3 H bond 4-C(CH3)3-phenyl
28 (E)-CH=N-OCH3 H bond (3 -benzyloxy)phenyl
29 (E)-CH=N-OCH3 H bond [3-CH3-4-(6-CH3-pyridin-3- yloxy)]phenyl
30 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl OCH2CH(CH3)2
31 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl O(CH2)2-phenoxy
32 (E)-CH=N-OCH3 H bond (3-Cl-4-pyridin-2-yloxy)phenyl
33 (E)-CH=N- H bond l-(3-F-benzyl)indol-5-yl OCH2CH3
34 (E)-CH=N-OCH3 H bond l-(3-F-benzyl)indol-5-yl
35 (E)-CH=N-OCH3 H -CH2CF2- 6-CH3-pyridin-2-yl
36 (E)-CH=N-OCH3 H bond 3-Br-phenyl
37 (E)-CH=N- H bond (3-Cl-4-benzyloxy)phenyl OCH2CH3
38 (E)-CH=N-OCH3 H bond (3-Cl-4-pyridin-3-yloxy)phenyl
39 (E)-CH=N-OCH3 CH3 bond [3-Cl-4-(3-F-benzyloxy)]phenyl
40 (E)-CH=N-OCH3 CH2CH3 bond 1 -(3-F-benzyl)indazol-5-yl
41 (E)-CH=N- CH2CH3 bond 1 -(3-F-benzyl)indazol-5-yl OCH2CH3
42 (E)-CH=N-OCH3 CH2CH3 bond [3-Cl-4-(3-F-benzyloxy)]phenyl Cpd (*)-RA R2 L (R3-R4-R5-R6-R7)Ar
43 (E)-CH=N- CH2CH3 bond [3-Cl-4-(3-F-benzyloxy)]phenyl OCH2CH3
44 (E)-CH=N-(4- H bond 1 -(3-F-benzyl)indazol-5-yl OCH3-benzyloxy)
45 (£)-CH=N-(2- H bond 1 -(3-F-benzyl)indazol-5-yl OCH3-benzyloxy)
46 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl benzyloxy
47 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl OCH(CH3)2
48 (E)-CH=N-OCH3 H bond 1 -benzyl- indazol-5-yl
49 (E)-CH=N- H bond 1 -benzyl- indazol-5-yl OCH2CH3
50 (E)-CH=N-OCH3 H bond 1 -(3-CN-benzyl)indazol-5-yl
51 (E)-CH=N- H bond 1 -(3-CN-benzyl)indazol-5-yl OCH2CH3
52 (E)-CH=N- H bond 2-benzyl- indazol-5-yl OCH2CH3
53 (E)-CH=N-OCH3 CH3 bond 1 -(3-F-benzyl)indazol-5-yl
54 (E)-CH=N-OCH3 H bond l-(3-Cl-benzyl)indazol-5-yl
55 (E)-CH=N- H bond l-(3-Cl-benzyl)indazol-5-yl OCH2CH3
56 (E)-CH=N-OCH3 H bond l-(3-OCH3-benzyl)indazol-5-yl
57 (E)-CH=N- H bond l-(3-OCH3-benzyl)indazol-5-yl OCH2CH3
58 (E)-CH=N- H bond 2-(3-F-benzyl)benzoimidazol-5- OCH2CH3 yi
59 (E)-CH=N-OCH3 H bond 3-Cl-phenyl
60 (E)-CH=N-OCH3 H bond 2-(3-F-benzyl)benzoimidazol-5- yl
61 (E)-CH=N-OCH3 H bond [3-OCH3-4-(3-F- benzyloxy)]phenyl
62 (E)-CH=N- H bond [3-OCH3-4-(3-F- OCH2CH3 benzyloxy)]phenyl
63 (E)-CH=N-OCH3 H bond (3-Cl-4-OCH3)phenyl
64 (E)-CH=N-OCH3 H bond (3-Cl-4-morpholin-4-yl)phenyl
65 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl phenoxy
66 (E)-CH=N-OCH3 H bond 1 -(4-F-benzyl)indazol-5-yl Cpd (*)-RA R2 L (R3-R4-R5-R6-R7)Ar
67 (E)-CH=N- H bond 1 -(4-F-benzyl)indazol-5-yl OCH2CH3
68 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl O(CH2)2OCH3
69 (Z)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl O(CH2)3OH
70 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl O(CH2)3N(CH3)2
71 (E)-CH=N- H bond (3-Cl-4-benzyloxy)phenyl O(CH2)2OCH3
72 (E)-CH=N-OCH3 H bond 2-(3-F-phenyl)benzofuran-5-yl
73 (E)-CH=N-OCH3 H bond 2-benzyl-benzofuran-5-yl
74 (E)-CH=N-OCH3 H bond l-(3-F-benzyl)-2,3-dihydro- indol-5-yl
75 (E)-CH=N- H bond [3-Cl-4-(3-F-benzyloxy)]phenyl O(CH2)3OH
76 (E)-CH=N- H bond (3-Cl-4-benzyloxy)phenyl O(CH2)3OH
77 (E)-CH=N-OH H bond (3-Cl-4-benzyloxy)phenyl
78 (E)-CH=N- H bond (3-Cl-4-benzyloxy)phenyl O(CH2)2- morpholin-4-yl
79 (E)-CH=N-OH H bond [3-Cl-4-(3-F-benzyloxy)]phenyl
80 (E)-CH=N-OCH3 H bond (2-F-4-Cl)phenyl
81 (Z)-CH=N-OCH3 H bond (2-F-4-Cl)phenyl
82 (E)-CH=N-OCH3 H bond (2-F-4-Br)phenyl
83 (Z)-CH=N-OCH3 H bond (2-F-4-Br)phenyl
84 (E)-CH=N-OH H bond 1 -(3-F-benzyl)indazol-5-yl
85 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl O(CH2)3OH
86 (E)-CH=N-OCH3 CH3 bond (2-F-4-Br)phenyl
87 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl O(CH2)3- morpholin-4-yl
88 (E)-CH=N-OH H bond l-(3-F-benzyl)indol-5-yl
89 (E)-CH=N-OCH3 H bond (4-Cl-2-F-5-OH)phenyl
90 (Z)-CH=N-OCH3 H bond (4-Cl-2-F-5-OH)phenyl
91 (E)-CH=N- H bond l-(3-F-benzyl)indol-5-yl O(CH2)3OH Cpd (*)-RA R2 L (R3-R4-R5-R6-R7)Ar
92 (E)-CH=N- H bond 1 -(3-F-benzyl)indazol-5-yl O(CH2)3- piperidin- 1 -yl
93 (E)-CH=N- H bond [3-Cl-4-(3-F-benzyloxy)]phenyl O(CH2)2- morpholin-4-yl
94 (E)-CH=N- H bond [3-Cl-4-(3-F-benzyloxy)]phenyl O(CH2)2- piperidin-1-yl
95 (E)-CH=N- H bond (3-Cl-4-benzyloxy)phenyl O(CH2)2- piperidin- 1 -yl
96 (E)-CH=N- H bond [l-(3-F-benzyl)]indazol-5-yl O(CH2)2- piperidin-1-yl
97 (E)-CH=N-OCH3 H bond [3-Cl-4-(3,5-F2- benzyloxy)]phenyl
98 (E)-CH=N-OH H bond [3-Cl-4-(3,5-F2- benzyloxy)]phenyl
99 (E)-CH=N- H bond [3-Cl-4-(3,5-F2- O(CH2)2- benzyloxy)]phenyl morpholin-4-yl
100 (E)-CH=N-OH H -CH(S- phenyl CH3)-
101 (E)-CH=N- H bond l-(3-F-benzyl)indol-5-yl O(CH2)2- morpholin-4-yl
102 (E)-CH=N- H bond l-(3-F-benzyl)indol-5-yl O(CH2)2- piperidin-1-yl
103 (E)-CH=N- H -CH(S- phenyl O(CH2)2- CH3)- morpholin-4-yl
104 (E)-CH=N-OCH3 H bond [4-NHC(O)-phenyl]phenyl
105 (E)-CH=N-OH H bond [4-NHC(O)-phenyl]phenyl
106 (E)-CH=N- H -CH(S- phenyl O(CH2)2- CH3)- piperidin-1-yl
107 (E)-CH=N- H bond [4-NHC(O)-phenyl]phenyl O(CH2)2- morpholin-4-yl Cpd (*)-RA R2 L (R3-R4-R5-R6-R7)Ar
108 (E)-CH=N- H bond (3-Cl-4-F)phenyl O(CH2)2- morpholin-4-yl
109 (E)-CH=N- H bond (4-phenoxy)phenyl O(CH2)2- morpholin-4-yl
110 (E)-CH=N-OCH3 H bond [2-NHC(O)-phenyl]pyrimidin-5- yi
111 (E)-CH=N-OH H bond (4-phenoxy)phenyl
112 (E)-CH=N- H bond (3-Cl-4-benzyloxy)phenyl O(CH2)3- morpholin-4-yl
113 (E)-CH=N- H bond (3-Cl-4-benzyloxy)phenyl O(CH2)3O- SO2CH3
114 (E)-CH=N-OCH2- H bond (3-Cl-4-benzyloxy)phenyl pyridin-2-yl
115 (E)-CH=N- H bond (3-Cl-4-benzyloxy)phenyl O(CH2)3- NH(CH2)2-OCH3
116 (E)-CH=N- H bond (3-Cl-4-benzyloxy)phenyl O(CH2)3-(4-OH- piperidin- 1 -yl)
117 (E)-CH=N-OCH2- H bond (3-Cl-4-benzyloxy)phenyl (1 -C(O)O- C(CH3),- piperidin-4-yl)
118 CN H bond (3-Cl-4-benzyloxy)phenyl
119 (E)-CH=N-CH2- H -CH2- benzo[l,3]dioxol-5-yl benzo[l,3]dioxol- 5-yl
120 (E)-CH=N-OCH3 H bond (4-OCH3)phenyl
121 (E)-CH=N-OCH3 H -CH2- benzo[l,3]dioxol-5-yl
122 (E)-CH=N-OCH3 H bond [3,4-OCH3)2]benzyl
123 (E)-CH=N-OCH3 H bond (4-phenoxy)benzyl
124 (E)-CH=N-OCH3 H bond (lR)-indan-l-yl
125 (E)-CH=N-OCH3 H bond 1 ,2,3,4-tetrahydro-naphthalen- 1 - yi
126 (E)-CH=N-OCH3 H -CH(CH3)- (4-Cl)phenyl
127 (E)-CH=N-OCH3 H -CH[(5)- (4-OCH3)phenyl CH3)]- Cpd (*)-RA R? L (R3-R4-R5-Re-R7)Ar
128 (^)-CH=N-OCH3 H bond (2-phenoxy)pyridin-5-yl
129 (^)-CH=N-OCH3 H bond (2-morpholin-4-yl)pyridin-5-yl
130 (^)-CH=N-OCH3 H bond 1 ,4-dioxo- 1 ,2,3,4-tetrahydro- phthalazin-5-yl
131 (£>CH=N-OCH3 H bond (2-F-5-CH3)phenyl
132 (£>CH=N-OCH3 H bond [2,4,6-(CH3)3]phenyl
133 (£>CH=N-OCH3 H bond (2-CH3-3-Cl)phenyl
134 (£>CH=N-OCH3 H bond (3-SCH3)phenyl
135 (£>CH=N-OCH3 H bond [3-C(CH3)=N(OCH3)]phenyl
136 (£>CH=N-OCH3 H bond [3,5-(CH3)2]phenyl
137 (£>CH=N-OCH3 H bond [4-NHC(O)CH3]phenyl
138 (£>CH=N-OCH3 H bond phenyl
139 (£>CH=N-OCH3 H bond (4-morpholin-4-yl)phenyl
140 (£>CH=N-OCH3 H bond (2-CH3)phenyl
141 (£>CH=N-OCH3 H bond (3,4-F2)phenyl
142 (£>CH=N-OCH3 H bond (3-F-4-CH3)phenyl
143 (£>CH=N-OCH3 H bond (3,4-Cl2)phenyl
144 (£>CH=N-OCH3 H bond (3-Cl-4-CH3)phenyl
145 (£>CH=N-OCH3 H bond {2-CH3-4-[CH2C(O)-phenyl]-5- Cl} phenyl
146 (£>CH=N-OCH3 H bond (3-CH2CH3)phenyl
147 (£>CH=N-OCH3 H bond [4-CH(CH3)2]phenyl
148 (£)-CH=N-OCH3 H bond indazol-5-yl
149 (£)-CH=N-OCH3 H bond (3-CF3)phenyl
150 (£)-CH=N-OCH3 H bond (3-CH3)phenyl
151 (£>CH=N-OCH3 H bond (4-Cl)phenyl
152 (£)-CH=N-OCH3 H bond (2-CH3-4-Cl)phenyl
153 (£)-CH=N-OCH3 H bond (4-NH-phenyl)phenyl
154 (£)-CH=N-OCH3 H bond [4-N(CH2CH3)2]phenyl
155 (£)-CH=N-OCH3 H bond [4-C(O)OCH3]phenyl
156 (£>CH=N-OCH3 H bond [4-C(phenyl)=N(OCH3)]phenyl
157 (£)-CH=N-OCH3 H bond [4-C(O)CH3]phenyl
158 (£)-CH=N-OCH3 H bond [4-C(CH3)=N(OCH3)]phenyl
159 (£)-CH=N-OCH3 H bond (4-CH2CN)phenyl
160 (^-CH=N-OCH3 H bond [2-OCH3-4-(NH-phenyl)]phenyl Cpd (*)-RA R? L (R3-R4-R5-Re-R7)Ar
161 (^)-CH=N-OCH3 H bond [2-OCH3-4-NHC(O)CH3]phenyl
162 (^)-CH=N-OCH3 H bond (4-cyclohexyl)phenyl
163 (£>CH=N-OCH3 H bond naphthalen-1-yl
164 (£>CH=N-OCH3 H bond (4-Cl)naphthalen- 1 -yl
165 (£>CH=N-OCH3 H bond (2,4-F2)phenyl
166 (£>CH=N-OCH3 H bond (2-SCH3)phenyl
167 (£>CH=N-OCH3 H bond (3-F)phenyl
168 (£>CH=N-OCH3 H bond (2-CH3-5-F)phenyl
169 (£>CH=N-OCH3 H bond (3,5-Cl2)phenyl
170 (£>CH=N-OCH3 H bond (2-OCH3-5-Cl)phenyl
171 (£>CH=N-OCH3 H bond (2-CH3-5-Cl)phenyl
172 (£>CH=N-OCH3 H bond (4-F)phenyl
173 (£>CH=N-OCH3 H bond biphenyl
174 (£>CH=N-OCH3 H bond (4-SCH3)phenyl
175 (£>CH=N-OCH3 H bond [3,5-(OCH3)2]phenyl
176 (£>CH=N-OCH3 H bond [3,4,5-(OCH3)3]phenyl
177 (£>CH=N-OCH3 H bond [3,4-(OCH3)2]phenyl
178 (^)-CH=N-OCH3 H bond 5,6,7,8-tetrahydro-naphthalen- 1 - yi
179 (£>CH=N-OCH3 H bond (4-SO2NH-pyrimidin-2- yl)phenyl
180 (£>CH=N-OCH3 H bond [3-C(O)OCH2CH3]phenyl
181 (£>CH=N-OCH3 H bond [4-CH2P(=O)- (OCH2CH3)2]phenyl
182 (£>CH=N-OCH3 H bond (4-CH2CH3)phenyl
183 (£>CH=N-OCH3 H bond (4-{SO2NH-[3,5-(CH3)2- pyrazin-2-yl] } )phenyl
184 (£>CH=N-OCH3 H bond (2-CH3)benzothiazol-5-yl
185 (£>CH=N-OCH3 H bond [4-NH-(4-OCH3-phenyl)]phenyl
186 (£>CH=N-OCH3 H bond [4-N(CH3)2]phenyl
187 (^)-CH=N-OCH3 H bond [4-C(O)NH(CH2)2- N(CH2CH3)2]phenyl
188 (£)-CH=N-OCH3 H bond [4-C(O)O(CH2)3CH3]phenyl
189 (£)-CH=N-OCH3 H bond indan-4-yl
190 (£)-CH=N-OCH3 H bond (4'-Cl)biphenyl
191 (£)-CH=N-OCH3 H bond [2-(4-F-phenoxy)]pyridin-5-yl Cpd (*)-RA R2 L (R3-R4-R5-Re-R7)Ar
192 (^)-CH=N-OCH3 H bond [4'-C(O)OCH3]biphenyl
193 [5-(CH2)2- H bond (3-Cl-4-benzyloxy)phenyl morpholin-4-yl]- [l,3,4]oxadiazol- 2-yl
Examples of a compound of Formula (I) include compounds selected from the group consisting of:
Figure imgf000037_0001
Figure imgf000037_0002
Cpd l Cpd 2 Cpd 3 Cpd 4
Figure imgf000037_0003
Figure imgf000037_0004
Cpd
Figure imgf000038_0001
Cpd9 CpdlO Cpdll
Figure imgf000038_0002
Figure imgf000038_0003
Cpdl3 Cpdl4 Cpdl5 Cpdlό
Figure imgf000039_0001
Cpdl7 Cpdl8 Cpdl9 Cpd20
Figure imgf000039_0002
Figure imgf000039_0003
Cpd21 Cpd22 Cpd23 Cpd24
Figure imgf000039_0004
Figure imgf000039_0005
Cpd25 Cpd26 Cpd27 Cpd28
Figure imgf000040_0001
Figure imgf000040_0002
Figure imgf000040_0003
Cpd35 Cpd36
Figure imgf000041_0001
Cpd37 Cpd38 Cpd39
Figure imgf000041_0002
Figure imgf000042_0001
Figure imgf000042_0003
Cpd52
Figure imgf000043_0001
Cpd53 Cpd54 Cpd55 Cpd56
Figure imgf000043_0002
Cpdόl Cpd62 Cpd63 Cpd64
Figure imgf000044_0001
Cpd65 Cpd66 Cpd67
Figure imgf000044_0002
Cpd69 Cpd70 Cpd71 Cpd72
Figure imgf000045_0001
Cpd73 Cpd74 Cpd75 Cpd76
Figure imgf000045_0002
Cpd77 Cpd78 Cpd79 Cpd80
Figure imgf000046_0001
Cpd81 Cpd82 Cpd83 Cpd84
Figure imgf000046_0002
Figure imgf000047_0001
Cpd89 Cpd90 Cpd91 Cpd92
Figure imgf000047_0002
Cpd93 Cpd94 Cpd95 Cpd96
Figure imgf000048_0001
Cpd 97 Cpd 98 Cpd 99 Cpd 100
Figure imgf000048_0002
Cpd 101 Cpd 102 Cpd 103 Cpd 104
Figure imgf000049_0001
Cpd 105 Cpd 106 Cpd 107 Cpd 108
Figure imgf000049_0002
Cpd 109 Cpd 110 Cpd 111 Cpd 112
Figure imgf000050_0001
Cpd 113 Cpd 1 14 Cpd 115 Cpd 116
Figure imgf000050_0002
Cpd 117 Cpd 118 Cpd 119 Cpd 120
Figure imgf000051_0001
Cpd 121 Cpd 122 Cpd 123 Cpd 124
Figure imgf000051_0002
Cpd 125 Cpd 126 Cpd 127 Cpd 128
Figure imgf000051_0003
Cpd 129 Cpd 130 Cpd 131 Cpd 132
Figure imgf000052_0001
Cpd 133 Cpd 134 Cpd 135 Cpd 136
Figure imgf000052_0002
Cpd 137 Cpd 138 Cpd 139 Cpd 140
Figure imgf000052_0003
Cpd 141 Cpd 142 Cpd 143 Cpd 144
Figure imgf000053_0001
Cpd 145 Cpd 146 Cpd 147 Cpd 148
Figure imgf000053_0002
Cpd 149 Cpd 150 Cpd 151 Cpd 152
Figure imgf000053_0003
Cpd 153 Cpd 154 Cpd 155 Cpd 156
Figure imgf000054_0001
Cpd 157 Cpd 159 Cpd 160
Figure imgf000054_0002
Cpd 161 Cpd 162 Cpd 163 Cpd 164
Figure imgf000054_0003
Cpd 165 Cpd 166 Cpd 167 Cpd 168
Figure imgf000055_0001
Cpd 169 Cpd 170 Cpd 171 Cpd 172
Figure imgf000055_0002
Cpd 173 Cpd 174 Cpd 175 Cpd 176
Figure imgf000055_0003
Cpd 177 Cpd 178 Cpd 179 Cpd 180
Figure imgf000056_0001
Cpd 181 Cpd 182 Cpd 183 Cpd 184
Figure imgf000056_0002
Cpd 185 Cpd 186 Cpd 188
Figure imgf000056_0003
Cpd 189 Cpd 190 Cpd 191 Cpd 192
Figure imgf000057_0001
Cpd 193 Chemical Definitions & Nomenclature
Bond lines drawn into a ring system from a substituent variable indicate that the substituent may be attached to any of the substitutable ring atoms.
As used herein, the following terms are intended to have the following definitions. The definitions herein may specify that a chemical term has an indicated formula. The particular formula provided is not intended to limit the scope of the invention, but is provided as an illustration of the term. The scope of the per se definition of the term is intended to include the plurality of variations expected to be included by one of ordinary skill in the art. Chemical terms are to be read from right to left, wherein the right-most group is attached to the core molecule and the left-most group is the terminal group. The formula(s) illustrating a term are to be read from left to right, wherein the left-most group is attached to the core molecule, as indicated by the dash, and the right-most group is the terminal group.
The term "Ci-salkyl" means a saturated aliphatic branched or straight-chain hydrocarbon radical or linking group having from 1 up to 8 carbon atoms in a linear or branched arrangement, wherein the radical is derived by the removal of one hydrogen atom from a carbon atom and the linking group is derived by the removal of one hydrogen atom from each of two carbon atoms in the chain. The term "Ci-salkyl" also includes a "Ci_6alkyl" and "Ci_4alkyl" radical or linking group having from 1 up to 6 carbon atoms and 1 up to 4 carbon atoms respectively, such as methyl, ethyl, 1 -propyl, 2-propyl, 1 -butyl, 2-butyl, tert-butyi, 1-pentyl, 2-pentyl, 3-pentyl, 1-hexyl, 2-hexyl, 3- hexyl, 1-heptyl, 2-heptyl, 3-heptyl, 1-octyl, 2-octyl, 3-octyl and the like. Alkyl radicals may be attached to a core molecule via a terminal carbon atom or via a carbon atom within the chain. Similarly, substituent variables may be attached to an alkyl linking group when allowed by available valences.
The term "C2-salkenyl" means an alkyl radical or linking group having from 2 up to 8 carbon atoms in a linear or branched arrangement having at least one carbon- carbon double bond. The term "C2-salkenyl" also includes a "C2-4alkenyl" radical or linking group having from 2 up to 4 carbon atoms, such as ethenyl (also referred to as vinyl), ώo-propenyl, allyl (also referred to as propenyl), propylidene and the like.
The term "Ci-salkoxy" means an alkyl radical or linking group having from 1 up to 8 carbon atoms in a linear or branched arrangement, wherein the radical or linking group is attached through an oxygen linking atom, as in the formula: -O-Ci_8alkyl. The term "Ci-salkoxy" also includes a "Ci_6alkoxy" and "Ci_4alkoxy" radical or linking group having from 1 up to 6 carbon atoms and from 1 up to 4 carbon atoms respectively, such as methoxy, ethoxy, propoxy, butoxy and the like. An alkoxy radical may be attached to a core molecule and further substituted as a linking group where indicated. The term "C3_i2cycloalkyl" means a saturated or partially unsaturated cyclic hydrocarbon ring system radical. The term "Cs.^cycloalkyl" also includes a C3-8cycloalkyl, Cs-iocycloalkyl, Cs-βcycloalkyl, Cs-scycloalkyl, Cs-^cycloalkyl, C9_i3Cycloalkyl or benzofused-Cs.^cycloalkyl ring system radical and the like, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, lH-indenyl, indanyl, 9Η-fluorenyl, 1,2,3,4-tetrahydro-naphthalenyl, acenaphthenyl, adamantanyl and the like.
The term "benzofused-Cs.^cycloalkyl" means a C3_i2cycloalkyl ring system radical having a benzene ring fused on the ring system on adjacent carbons. Examples of benzofused-Cs-^cycloalkyl in compounds representative of the present invention include a benzofused-Cs-βcycloalkyl ring system radical and the like, such as lH-indenyl, indanyl and the like. The term "aryl" means an unsaturated aromatic hydrocarbon ring system radical. Aryl ring systems include phenyl, naphthalenyl, azulenyl, anthracenyl and the like. Examples of aryl in compounds representative of the present invention include phenyl or naphthalenyl. The term "hetero", when used as a prefix for a ring system, refers to the replacement of at least one carbon atom member in the ring system with a heteroatom selected from N, O, S, S(O), or SO2. A hetero ring may have 1, 2, 3 or 4 carbon atom members replaced by a nitrogen atom. Alternatively, a ring may have 1 , 2 or 3 nitrogen atom members and 1 oxygen or sulfur atom member. Alternatively, a ring may have 1 oxygen or sulfur atom member. Alternatively, up to two adjacent ring members may be heteroatoms, wherein one heteroatom is nitrogen and the other heteroatom is selected from N, S or O.
The term "heterocyclyl" means a saturated or partially unsaturated "hetero" ring system radical. Heterocyclyl ring systems include azetidinyl, 2H-pyrrole, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolidinyl, 1,3-dioxolanyl, 2-imidazolinyl (also referred to as 4,5- dihydro-lH-imidazolyl), imidazolidinyl, 2-pyrazolinyl, pyrazolidinyl, tetrazolyl, tetrazolidinyl, piperidinyl, 1 ,4-dioxanyl, morpholinyl, 1 ,4-dithianyl, thiomorpholinyl, piperazinyl, azepanyl, hexahydro-l,4-diazepinyl, hexahydro-l,4-oxazepanyl, tetrahydro-furanyl, tetrahydro-thienyl, tetrahydro-pyranyl, tetrahydro-pyridazinyl and the like. The term "heterocyclyl" also includes a benzofused-heterocyclyl ring system radical and the like, such as indolinyl (also referred to as 2,3-dihydro-indolyl), benzo[l,3]dioxolyl, 2,3-dihydro-l,4-benzodioxinyl, 2,3-dihydro-benzofuranyl, 1,2- dihydro-phthalazinyl and the like.
The term "benzofused-heterocyclyl" means a heterocyclyl ring system radical having a benzene ring fused on the ring system on adjacent carbons. Examples of benzofused-heterocyclyl in compounds representative of the present invention include benzo[l,3]dioxolyl and 2,3-dihydro-indolyl.
The term "heteroaryl" means a monovalent, unsaturated aromatic "hetero" ring system radical. Heteroaryl ring systems include furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and the like. The term "heteroaryl" also includes a benzofused-heteroaryl ring system radical and the like, such as indolizinyl, indolyl, azaindolyl, isoindolyl, benzofuranyl, benzothienyl, indazolyl, azaindazolyl, benzoimidazolyl, benzothiazolyl, benzoxazolyl, benzoisoxazolyl, benzothiadiazolyl, benzotriazolyl, purinyl, 4H-quinolizinyl, quinolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, 1,8- naphthyridinyl, pteridinyl and the like.
The term "benzofused-heteroaryl" means a heteroaryl ring system radical having a benzene ring fused on the ring system on adjacent carbons. Examples of benzofused-heteroaryl in compounds representative of the present invention include indazolyl, indolyl, benzofuranyl and benzoimidazolyl.
The term "Ci_gacyl" means a radical of the formula: -C(O)H or -C(O)-C i_galkyl, or a linking group of the formula: -C(O)-Ci_8alkyl-terminal group.
The term "Ci.gacyl-amino" means a radical of the formula: -NH-C(O)H or -NH-C(O)-Ci_8alkyl, or a linking group of the formula: -NH-C(O)-Ci_8alkyl-terminal group.
The term "Ci_8alkoxy-Ci_8alkyl" means a radical of the formula: -Ci_8alkyl-O-Ci_8alkyl, or a linking group of the formula: -Ci-salkyl-O-Ci-salkyl-terminal group.
The term "Ci.galkoxy-Ci.galkyl-amino-Ci.galkyl" means a radical of the formula: -Ci_8alkyl-NH-Ci_8alkyl-O-Ci_8alkyl,
-Ci.8alkyl-N[(Ci.8alkyl)(Ci.8alkyl-O-Ci.8alkyl)] or -Ci.8alkyl-N(Ci.8alkyl-O-Ci.8alkyl)2, or a linking group of the formula: -Ci-salkyl-NH-Ci-salkyl-O-Ci-salkyl-terminal group, -Ci_8alkyl-N[(Ci_8alkyl)(Ci_8alkyl-O-Ci_8alkyl-terminal group)], -Ci_8alkyl-N[(Ci_8alkyl-terminal group)(Ci_8alkyl-O-Ci_8alkyl)] or -Ci.8alkyl-N[(Ci.8alkyl)(Ci.8alkyl-O-Ci.8alkyl-terminal group)].
The term "Ci-salkoxycarbonyl" means a radical of the formula: -C(O)-O-Ci_8alkyl, or a linking group of the formula: -C(O)-O-Ci_8alkyl-terminal group.
The term "Ci_8alkoxy-imino-Ci_8alkyl" means a radical of the formula: -Ci_8alkyl=N(Ci_8alkoxy). The term "Ci_8alkoxy-imino-(aryl)Ci_8alkyl" means a radical of the formula: -Ci_8alkyl(aryl)=N(Ci_8alkoxy); wherein the aryl and imino portion is substituted on the same or different Ci_salkyl carbon atom.
The term "Ci_8alkyl-amino" means a radical of the formula: -NH-Ci_salkyl or -N(Ci_8alkyl)2.
The term "Ci_8alkyl-amino-Ci_8alkyl" means a radical of the formula: -Ci.galkyl-NH-Ci.galkyl or -Ci_8alkyl-N(Ci_8alkyl)2, or a linking group of the formula: -Ci.galkyl-NH-Ci.galkyl-terminal group or -Ci_8alkyl-N(Ci_8alkyl)-Ci_8alkyl-terminal group. The term "Ci-salkyl-amino-Ci-salkyl-amino-carbonyl" means a radical of the formula: -C(O)-NH-Ci.8alkyl-NH-Ci.8alkyl or -C(O)-NH-Ci_8alkyl-N(Ci_8alkyl)2.
The term "Ci.salkyl-sulfonyl-Ci.salkyl" means a radical of the formula: -Ci_8alkyl-SO2-Ci_8alkyl, or a linking group of the formula: -Ci_8alkyl-SO2-Ci_8alkyl-terminal group. The term "Ci.galkyl-sulfonyloxy-Ci.galkyl" means a radical of the formula:
-Ci_8alkyl-O-SO2-Ci_galkyl, or a linking group of the formula: -Ci_8alkyl-O-SO2-Ci_8alkyl-terminal group.
The term "amino" means a radical of the formula: -NH2.
The term "amino-Ci_8alkyl" means a radical of the formula: -Ci_salkyl-NH2, or a linking group of the formula: -Ci_8alkyl-NH-terminal group or -Ci_8alkyl-N(terminal group)2.
The term "aryl-amido" means a radical of the formula: -NHC(O)-aryl.
The term "aryl-amino" means a radical of the formula: -NH-aryl.
The term "aryl-Ci_8alkyl" means a radical of the formula: -Ci_8alkyl-aryl. The term "aryl-carbonyl-Ci_8alkyl" means a radical of the formula:
-Ci_8alkyl-C(O)-aryl.
The term "aryl-Ci_8alkoxy" means a radical of the formula: -O-Ci_8alkyl-aryl.
The term "aryloxy" means a radical of the formula: -O-aryl.
The term "aryloxy-Ci-salkyl" means a radical of the formula: -Ci_8alkyl-O-aryl. The term "carboxy" means a radical of the formula: -C(O)OH.
The term "cyano-Ci-salkyl" means a radical of the formula: -Ci_8alkyl-C≡N.
The term "halogen" or "halo" means the group chloro, bromo, fluoro or iodo.
The term "halo-Ci_8alkoxy" means a radical of the formula: -Ci_8alkoxy(halo)i_i7, wherein one or more halogen atoms may be substituted on Ci_galkoxy when allowed by available valences and includes monofluoromethoxy, difluoromethoxy, trifluoromethoxy, trifluoroethoxy and the like.
The term "halo-Ci_6alkoxy" means a radical of the formula: -Ci_6alkoxy(halo)i_i3, wherein one or more halogen atoms may be substituted on Ci_6alkoxy when allowed by available valences.
The term "halo-Ci_8alkyl" means a radical of the formula: -Ci_8alkyl(halo)i_i7, wherein one or more halogen atoms may be substituted on Ci_8alkyl when allowed by available valences and includes monofluoromethyl, difluoromethyl, trifluoromethyl, trifluoroethyl and the like. The term "halo-Ci_6alkyl" means a radical of the formula: -Ci_6alkyl(halo)i_i3, wherein one or more halogen atoms may be substituted on Ci_6alkyl when allowed by available valences.
The term "heterocyclyl-Ci-salkyl" means a radical of the formula: -Ci_8alkyl-heterocyclyl. The term "heterocyclyl-carbonyl-Ci-salkyl" means a radical of the formula:
-Ci_8alkyl-C(O)-heterocyclyl.
The term "heteroaryl-Ci_galkoxy" means a radical of the formula: -O-Ci_8alkyl-heteroaryl.
The term "heteroaryl-Ci.galkyl" means a radical of the formula: -Ci_8alkyl-heteroaryl.
The term "heteroaryl-amino-sulfonyl" means a radical of the formula: -SO2-NH-heteroaryl.
The term "heteroaryloxy" means a radical of the formula: -O-heteroaryl. The term "hydroxy-Ci-salkoxy" means a radical wherein Ci_8alkoxy is substituted on an available carbon chain atom with one or more hydroxy radicals.
The term "hydroxy-Ci.galkyl" means a radical wherein Ci_galkyl is substituted on an available carbon chain atom with one or more hydroxy radicals.
The term "substituted phosphonic acid" means a radical of the formula: -P(=O)-(O-Ci_8alkyl)2, -P(=O)-(OH)2 or -P(=O)(OH)-O-C1-8alkyl.
The term "thio-Ci_8alkyl" means a radical of the formula: -S-Ci_8alkyl.
The term "substituted" means the independent replacement of one or more hydrogen atoms within a radical with that amount of substituents allowed by available valences. The term "dependency selected" means that the structure variables are specified in an indicated combination.
The term "terminal group" means a moiety attached to a linking group substituent at a position other than the point of attachment of the linking group to the core molecule. The moiety functions to terminate the structure variable. In general, IUPAC nomenclature rules are used herein.
Compound Forms
The term "form" means, in reference to compounds of the present invention, such may exist as, without limitation, a salt, stereoisomer, tautomer, crystalline, polymorph, amorphous, solvate, hydrate, ester, prodrug or metabolite form. The present invention encompasses all such compound forms and mixtures thereof.
The term "isolated form" means, in reference to compounds of the present invention, such may exist in an essentially pure state such as, without limitation, an enantiomer, a racemic mixture, a geometric isomer (such as a cis or trans stereoisomer), a mixture of geometric isomers, and the like. The present invention encompasses all such compound forms and mixtures thereof.
The compounds of the invention may be present in the form of pharmaceutically acceptable salts. For use in medicines, the "pharmaceutically acceptable salts" of the compounds of this invention refer to non-toxic acidic/anionic or basic/cationic salt forms. Suitable salt forms include acid addition salts which may, for example, be formed by mixing a solution of the compound according to the invention with a solution of an acid such as acetic acid, adipic acid, benzoic acid, carbonic acid, citric acid, fumaric acid, glycolic acid, hydrochloric acid, maleic acid, malonic acid, phosphoric acid, saccharinic acid, succinic acid, sulphuric acid, tartaric acid, trifluoroacetic acid and the like.
Furthermore when the compounds of the present invention carry an acidic moiety, suitable salts thereof may include alkali metal salts, e.g. sodium or potassium salts; alkaline earth metal salts, e.g. calcium or magnesium salts; and salts formed with suitable organic ligands, e.g. quaternary ammonium salts.
Thus, representative salts include the following: acetate, adipate, benzenesulfonate, benzoate, bicarbonate, bisulfate, bitartrate, borate, bromide, calcium, camsylate (or camphosulphonate), carbonate, chloride, clavulanate, citrate, dihydrochloride, edetate, fumarate, gluconate, glutamate, glyconate, hydrabamine, hydrobromine, hydrochloride, iodide, isothionate, lactate, malate, maleate, malonate, mandelate, mesylate, nitrate, oleate, pamoate, palmitate, phosphate/diphosphate, saccharinate, salicylate, stearate, sulfate, succinate, tartrate, tosylate, trichloroacetate, trifluoroacetate and the like.
Examples of salt forms of compounds representative of the present invention include the monohydrochloride salt.
During any of the processes for preparation of the compounds of the present invention, it may be necessary and/or desirable to protect sensitive or reactive groups on any of the molecules concerned. This may be achieved by means of conventional protecting groups, such as those described in Protective Groups in Organic Chemistry, ed. J.F.W. McOmie, Plenum Press, 1973; and T.W. Greene & P.G.M. Wuts, Protective Groups in Organic Synthesis, 3rd Edition, John Wiley & Sons, 1999. The protecting groups may be removed at a convenient subsequent stage using methods known in the art. The scope of the present invention encompasses all such protected compound forms and mixtures thereof. The invention includes compounds of various isomers and mixtures thereof.
The term "isomer" refers to compounds that have the same composition and molecular weight but differ in physical and/or chemical properties. Such substances have the same number and kind of atoms but differ in structure. The structural difference may be in constitution (geometric isomers) or in an ability to rotate the plane of polarized light (optical isomers). The term "optical isomer" means isomers of identical constitution that differ only in the spatial arrangement of their groups. Optical isomers rotate the plane of polarized light in different directions. The term "optical activity" means the degree to which an optical isomer rotates the plane of polarized light.
The term "racemate" or "racemic mixture" means an equimolar mixture of two enantiomeric species, wherein each of isolated specie rotates the plane of polarized light in the opposite direction such that the mixture is devoid of optical activity.
The term "enantiomer" means an isomer having a nonsuperimposable mirror image. The term "diastereomer" means stereoisomers that are not enantiomers.
The term "chiral" means a molecule which, in a given configuration, cannot be superimposed on its mirror image. This is in contrast to achiral molecules which can be superimposed on their mirror images.
The two distinct mirror image versions of the chiral molecule are also known as levo (left-handed), abbreviated L, or dextro (right handed), abbreviated D, depending on which way they rotate polarized light. The symbols "R" and "S" represent the configuration of groups around a stereogenic carbon atom(s).
An example of an isolated form of an achiral mixture includes a dextrorotatory enantiomer, wherein the mixture is substantially free of the levorotatory isomer. In this context, substantially free means the levorotatory isomer may, in a range, comprise less than 25% of the mixture, less than 10 %, less than 5 %, less than 2 % or less than 1 % of the mixture according to the formula: n / , (mass levorotatory) Λ nn
% levorotatory = — x 100
(mass dextrorotatory) + (mass levorotatory)
Similarly, an example of an isolated form of an achiral mixture includes a levorotatory enantiomer, wherein the mixture is substantially free of the dextrorotatory isomer. In this context, substantially free means the dextrorotatory isomer may, in a range, comprise less than 25% of the mixture, less than 10 %, less than 5 %, less than 2 % or less than 1 % of the mixture according to the formula: n / , (mass dextrorotatory) Λ nn
% dextrorotatory = — x 100
(mass dextrorotatory) + (mass levorotatory)
The term "geometric isomer" means isomers that differ in the orientation of substituent atoms in relationship to a carbon-carbon double bond, to a cycloalkyl ring, or to a bridged bicyclic system. Substituent atoms (other than hydrogen) on each side of a carbon-carbon double bond may be in an E or Z configuration. In the "E" configuration, the substituents are on opposite sides in relationship to the carbon- carbon double bond. In the "Z" configuration, the substituents are oriented on the same side in relationship to the carbon-carbon double bond. Substituent atoms (other than hydrogen) attached to a ring system may be in a cis or trans configuration. In the "cis" configuration, the substituents are on the same side in relationship to the plane of the ring; in the "trans" configuration, the substituents are on opposite sides in relationship to the plane of the ring. Compounds having a mixture of "cis" and "trans" species are designated "cis/trans". The isomeric descriptors ("R," "S," "E," and "Z") indicate atom configurations and are intended to be used as defined in the literature.
The compounds of the invention may be prepared as individual isomers by either isomer-specific synthesis or resolved from an isomeric mixture. Conventional resolution techniques include combining the free base (or free acid) of each isomer of an isomeric pair using an optically active acid (or base) to form an optically active salt (followed by fractional crystallization and regeneration of the free base), forming an ester or amide of each of the isomers of an isomeric pair by reaction with an appropriate chiral auxiliary (followed by fractional crystallization or chromatographic separation and removal of the chiral auxiliary), or separating an isomeric mixture of either an intermediate or a final product using various well known chromatographic methods.
Furthermore, compounds of the present invention may have one or more polymorph or amorphous crystalline forms and, as such, are intended to be included in the scope of the invention. In addition, some of the compounds may form solvates with water (i.e., hydrates) or common organic solvents (e.g., organic esters such as ethanolate and the like) and, as such, are also intended to be encompassed within the scope of this invention..
Methods of Use
The compounds of formula (I) are inhibitors of a protein kinase such as EGFR, HER-I, HER-2 and the like, having an IC50 (50% inhibition concentration) or an EC50 (50% effective concentration) in a range of about 50 μM or less, of about 25 μM or less, of about 15 μM or less, of about 10 μM or less, of about 5 μM or less, of about 1 μM or less, of about 0.5 μM or less, of about 0.25 μM or less or of about 0.1 μM or less. The present invention includes a compound of formula (I) and forms thereof as a protein kinase inhibitor, wherein the protein kinase is selected from EGFR, HER-I or HER-2.
The present invention includes a prodrug form of a compound of formula (I) and forms thereof as a protein kinase inhibitor. The present invention includes a metabolite form of a compound of formula (I) and forms thereof as a protein kinase inhibitor.
The present invention includes an isolated form of a compound of formula (I) and forms thereof as a protein kinase inhibitor.
The present invention includes a compound of formula (I) or a form thereof, wherein the compound is labeled with a ligand for use as a marker, and wherein the ligand is a radioligand selected from deuterium, tritium and the like.
The present invention includes use of a compound of formula (I) and forms thereof as an inhibitor of a protein kinase such as EGFR, HER-I, HER-2 and the like comprising contacting the protein kinase domain or receptor with the compound. The present invention includes the use of a compound of formula (I) and forms thereof as a pharmaceutical composition, medicine or medicament for treating, preventing or ameliorating a kinase mediated disease, disorder or condition.
The present invention includes the use of a compound of formula (I) and forms thereof as a medicament. The present invention includes the use of a prodrug of a compound of formula (I) and forms thereof as a pharmaceutical composition, medicine or medicament for treating, preventing or ameliorating a kinase mediated disease, disorder or condition.
The present invention includes the use of a prodrug of a compound of formula (I) and forms thereof as a medicament.
The present invention is directed to a method for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I) and forms thereof. The method of the present invention further comprises administering to the subject an effective amount of a prodrug of a compound of formula (I) and forms thereof.
The method of the present invention further comprises treating, preventing or ameliorating a chronic or acute EGFR, HER-I or HER-2 mediated disease, disorder or condition.
The method of the present invention wherein the disease, disorder or condition is associated with increased or unregulated protein kinase activity, expression or signaling and the like in the subject.
The method of the present invention further comprises administering to the subject an effective amount of a compound of formula (I) as a pharmaceutical composition, medicine or medicament thereof.
The method of the present invention wherein the disease, disorder or condition is an EGFR kinase mediated head or brain cancer in the subject, and wherein the compound penetrates the blood brain barrier. The method of the present invention further comprises treating or ameliorating nerve damage and promoting axon regeneration subsequent to a brain or spinal cord injury in the subject, wherein the compound is an EGFR inhibitor.
The method of the present invention further comprises treating, preventing or ameliorating viral infection by an EGFR kinase mediated cytomegalovirus in the subject. The term "chronic or acute protein kinase mediated disease, disorder or condition" as used herein, includes, and is not limited to diseases, disorders or conditions associated with unregulated kinase activity and conditions that accompany such activity. The term "unregulated protein kinase activity, expression or signaling" refers to
1) increased or unregulated kinase expression or signaling, 2) increased kinase expression leading to unregulated cell proliferation, 3) increased kinase signaling leading to unregulated cell proliferation, or 4) mutations leading to constitutive kinase activation. The existence of unregulated kinase activity may be determined by procedures well known in the art.
The term "unregulated cell proliferation" refers to cell proliferation of one or more subset of cells in a multicellular organism resulting in harm (such as discomfort or decreased life expectancy) to the multicellular organism.
Tumor cells which result from unregulated cell proliferation use many mechanisms to enhance their survival and spread and often have high rates of proliferation because growth control signals that keep normal cells in check are defective. Many tumor cells secrete autocrine growth factors that increase proliferation rates or they induce other cells to secrete growth factors that they utilize.
Tumor cells grow and spread by dislodging from a primary tumor site, using proteases to digest the extracellular matrix, spreading in response to migration cues, allowing them to migrate to certain tissues preferentially where overexpressed adhesion molecules allow attachment and growth at the new site. The totality of these and other biological processes are responsible for the lethal effects of a tumor. A kinase inhibitor may affect one or more aspects of tumor survival mechanisms and thus be therapeutically useful. Alternatively, a kinase inhibitor may not affect one particular tumor survival mechanism but may still be therapeutically useful by affecting tumor survival by an unknown or as yet unelucidated mechanism of action.
The foregoing methods contemplate that a compound of formula (I) or a form thereof is useful for treating, preventing or ameliorating diseases, disorders or conditions such as, without limitation, osteoarthritis, rheumatoid arthritis, synovial pannus invasion in arthritis, multiple sclerosis, myasthenia gravis, diabetes mellitus, diabetic angiopathy, diabetic retinopathy, retinal vessel proliferation, inflammatory bowel disease, Crohn's disease, ulcerative colitis, bone diseases, transplant or bone marrow transplant rejection, lupus, chronic pancreatitis, cachexia, septic shock, fibroproliferative and differentiative skin diseases or disorders, central nervous system diseases, neurodegenerative diseases, disorders or conditions related to nerve damage and axon degeneration subsequent to a brain or spinal cord injury, acute or chronic cancer, ocular diseases, viral infections, heart disease, lung or pulmonary diseases or kidney or renal diseases.
Certain diseases, disorders or conditions further include, without limitation, acute or chronic cancer selected from bladder cancer, brain, head or neck cancer, breast cancer, colorectal cancer, endometrial cancer, epidermoid cancer, esophageal cancer, gastric cancer, glioma cancer, lung cancer, ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer, Kaposi's sarcoma, leukemia, lymphoma or papillocarcinoma; and, cancer-associated pathologies selected from abnormal cell proliferation, unregulated cell proliferation, tumor growth, tumor angiopathy, tumor angiogenesis, tumor vascularization or metastatic cancer cell invasion and migration.
Certain diseases, disorders or conditions further include, without limitation, fibroproliferative and differentiative skin diseases or disorders selected from papilloma formation, psoriasis, dermatitis, eczema, seborrhea or chemotherapy-induced alopecia; central nervous system diseases selected from Alzheimer's disease, Parkinson's disease or depression; ocular diseases selected from macular degeneration, diseases of the cornea or glaucoma; viral infections selected from mycotic infection, autoimmune disease or cytomegalovirus; heart disease selected from atherosclerosis, neointima formation or transplantation-induced vasculopathies such as arterial restenosis; lung or pulmonary diseases selected from allergic-asthma, lung fibrosis, pulmonary fibrosis or chronic obstructive pulmonary disorder; and, kidney or renal diseases selected from acute, subacute or chronic forms of glomerulonephritis or membranoproliferative glomerulonephritis, glomerulosclerosis, congenital multicystic renal dysplasia or kidney fibrosis. Certain HERl kinase mediated cancer includes, without limitation, bladder cancer, brain, head or neck cancer, breast cancer, cervical cancer, colorectal cancer, gastric cancer, glioma cancer, endometrial cancer, esophageal cancer, lung cancer, ovarian cancer, pancreatic cancer or renal cell cancer.
Certain HER2 kinase mediated cancer includes, without limitation, bladder cancer, brain, head or neck cancer, breast cancer, colorectal cancer, gastric cancer, endometrial cancer, esophageal cancer, lung cancer, ovarian cancer, prostate cancer or renal cell cancer.
The term "administering," with respect to the methods of the present invention, refers to a means for treating, ameliorating or preventing a disease, disorder or syndrome as described herein with a compound of formula (I) or a form thereof, which would obviously be included within the scope of the invention albeit not specifically disclosed for certain of said compounds.
Such methods include therapeutically or prophylactically administering an effective amount of compound of formula (I) or a form thereof at different times during the course of a therapy or concurrently in a combination form. Such methods further include administering an effective amount of said compound with one or more agents at different times during the course of a therapy or concurrently in a combination form.
The term "prodrug" means a compound of formula (I) or a form thereof that is converted in vivo into a functional derivative form that may contribute to therapeutic biological activity, wherein the converted form may be: 1) a relatively active form; 2) a relatively inactive form; 3) a relatively less active form; or, 4) any form which results, directly or indirectly, from such in vivo conversions.
Prodrugs are useful when said compound may be either too toxic to administer systemically, absorbed poorly by the digestive tract or broken down by the body before it reaches its target. Conventional procedures for the selection and preparation of suitable prodrug derivatives are described in, for example, "Design of Prodrugs", ed. H. Bundgaard, Elsevier, 1985.
The term "metabolite" means a prodrug form of a compound of formula (I) or a form thereof converted by in vivo metabolism or a metabolic process to a relatively less active functional derivative of said compound. The term "subject" as used herein, refers to a patient, such as an animal, a mammal or a human, who has been the object of treatment, observation or experiment and is at risk of (or susceptible to) developing a disease or disorder or having a disease or disorder related to unregulated kinase activity.
The term "effective amount" refers to that amount of a compound of formula (I) or a form, pharmaceutical composition, medicine or medicament thereof that elicits the biological or medicinal response (such as inhibiting activation of unregulated kinase activity) in a tissue system, animal or human, that is being sought by a researcher, veterinarian, medical doctor, or other clinician, which includes alleviation of the symptoms of the disease or disorder being treated.
The effective amount of said compound is from about 0.001 mg/kg/day to about 300 mg/kg/day.
The term "pharmaceutical composition" refers to a product containing a compound of formula (I) or a form thereof, such as a product comprising the specified ingredients in the specified amounts, as well as any product which results, directly or indirectly, from such combinations of the specified ingredients in the specified amounts.
The term "medicament" or "medicine" refers to a product containing a compound of formula (I) or a form thereof. The present invention includes use of such a medicament for treating, preventing or ameliorating a chronic or acute kinase mediated disease, disorder or condition. The term "pharmaceutically acceptable" refers to molecular entities and compositions that are of sufficient purity and quality for use in the formulation of a pharmaceutical composition, medicine or medicament of the present invention and that, when appropriately administered to an animal or a human, do not produce an adverse, allergic or other untoward reaction. Since both human use (clinical and over-the- counter) and veterinary use are equally included within the scope of the present invention, a pharmaceutically acceptable formulation would include a pharmaceutical composition, medicine or medicament for either human or veterinary use.
The term "combination form" refers to the use of a combination product comprising a compound of formula (I) or a form, pharmaceutical composition, medicine or medicament thereof and at least one therapeutic agent for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
Advantageously, the effective amount of a combination product for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition may be a reduced amount of either or both the compound or therapeutic agent compared to the effective amount of the compound or therapeutic agent otherwise recommended for treating, preventing or ameliorating the disease, disorder or condition. Therefore, it is contemplated that the compound is administered to the subject before, during or after the time the agent is administered.
The term "therapeutic agent" refers to chemotherapeutic agents used to treat a kinase mediated cancer or antiviral agents used to treat cytomegalovirus.
Chemotherapeutic agents include and are not limited to anti-angiogenic agents, antitumor agents, cytotoxic agents, inhibitors of cell proliferation, radiation therapy and the like or a combination thereof.
The term "treating, preventing or ameliorating" refers, without limitation, to facilitating the eradication of, inhibiting the progression of or promoting stasis of a chronic or acute kinase mediated disease, disorder or condition.
The term "radiation therapy" refers to a therapy that comprises exposing the subject in need thereof to radiation. The present invention includes a method for administering a compound of formula (I) or a form, pharmaceutical composition, medicine or medicament thereof in combination with radiation therapy. Procedures for administering such therapy are known to those skilled in the art. The appropriate scheme of radiation therapy will be similar to those already employed in clinical therapies wherein the radiation therapy is used alone or in combination with other chemotherapeutic agents. The present invention includes a pharmaceutical composition comprising an admixture of a compound of formula (I) or a form thereof and one or more pharmaceutically acceptable excipients.
The present invention includes a process for making a pharmaceutical composition, medicine or medicament comprising mixing a compound of formula (I) or a form thereof and an optional pharmaceutically acceptable carrier. The present invention includes a pharmaceutical composition, medicine or medicament resulting from the process of mixing a compound of formula (I) or a form thereof and an optional pharmaceutically acceptable carrier. Contemplated processes include both conventional and unconventional pharmaceutical techniques.
Said pharmaceutical composition, medicine or medicament may take a wide variety of forms to effectuate mode of administration, wherein the mode includes, and is not limited to, intravenous (both bolus and infusion), oral, nasal, transdermal, topical with or without occlusion, and via injection intraperitoneally, subcutaneously, intramuscularly, intratumorally, intracerebrally or intracranially. The composition, medicine or medicament may be in a dosage unit such as a tablet, pill, capsule, powder, granule, sterile parenteral solution or suspension, metered aerosol or liquid spray, drop, ampoule, auto-injector device or suppository for such administration modes.
Pharmaceutical compositions, medicines or medicaments suitable for oral administration include solid forms such as pills, tablets, caplets, capsules (each including immediate release, timed release and sustained release formulations), granules and powders; and, liquid forms such as solutions, syrups, elixirs, emulsions and suspensions. Forms useful for parenteral administration include sterile solutions, emulsions and suspensions. Alternatively, the pharmaceutical composition, medicine or medicament may be presented in a form suitable for once-weekly or once-monthly administration; for example, an insoluble salt of the active compound, such as the decanoate salt, may be adapted to provide a depot preparation for intramuscular injection.
The dosage form (tablet, capsule, powder, injection, suppository, teaspoonful and the like) containing the pharmaceutical composition, medicine or medicament contains an effective amount of the active ingredient necessary to be therapeutically or prophylactically effective as described above. The pharmaceutical composition, medicine or medicament may contain from about 0.001 mg to about 5000 mg (preferably, from about 0.001 to about 500 mg) of a compound of formula (I) or a form thereof and may be constituted into any form suitable for the mode of administration selected for a subject in need. An example of a contemplated effective amount for a pharmaceutical composition, medicine or medicament of the present invention may range from about 0.001 mg to about 300 mg/kg of body weight per day. In another example, the range is from about 0.003 to about 100 mg/kg of body weight per day. In another example, the range is from about 0.005 to about 15 mg/kg of body weight per day. The pharmaceutical composition, medicine or medicament may be administered according to a dosage regimen of from about 1 to about 5 times per day.
For oral administration, the pharmaceutical composition, medicine or medicament is preferably in the form of a tablet containing, e.g., 0.01, 0.05, 0.1, 0.5, 1.0, 2.5, 5.0, 10.0, 15.0, 25.0, 50.0, 100, 150, 200, 250 and 500 milligrams of a compound of formula (I) or a form thereof for the symptomatic adjustment of the dosage to the patient to be treated. Optimal dosages will vary depending on factors associated with the particular patient being treated (e.g., age, weight, diet and time of administration), the severity of the condition being treated, the particular compound being used, the mode of administration and the strength of the preparation. The use of either daily administration or post-periodic dosing may be employed.
A representative compound of formula (I) includes a compound selected from:
Cpd Names
1 (5£)-4-amino-6-(3-chloro-4-fluoro-phenylamino)-pyrimidine-5- carbaldehyde 0-methyl-oxime,
2 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde 0-methyl-oxime,
4 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino)- pyrimidine-5 -carbaldehyde 0-methyl-oxime,
6 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-2-oxo-ethyl)-oxime,
7 (5£)-4-amino-6-(3 -methoxy-4-phenoxy-phenylamino)-pyrimidine-5 - carbaldehyde 0-methyl-oxime,
8 (5£)-4-amino-6-(3 -methoxy-4-phenoxy-phenylamino)-pyrimidine-5 - carbaldehyde O-(2-morpholin-4-yl-2-oxo-ethyl)-oxime,
9 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde 0-methyl-oxime,
10 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime,
11 (5£)-4-amino-6-[ 1 -(3-fluoro-benzyl)- lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-allyl-oxime, Cpd Names
12 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-tert-butyl-oxime,
13 (5£)-4-amino-6-[3-methyl-4-(pyridin-3-yloxy)-phenylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
16 (5£)-4-amino-6-[(lS)-l-phenyl-ethylamino]-pyrimidine-5-carbaldehyde O- ethyl-oxime,
17 (5£)-4-amino-6-(lH-indol-5-ylamino)-pyrimidine-5-carbaldehyde 0-ethyl- oxime,
18 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino)- pyrimidine-5 -carbaldehyde O-ethyl-oxime,
19 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
24 (5£)-4-amino-6-(4-phenoxy-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
25 (5£)-4-amino-6-(4-benzyloxy-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
29 (5£)-4-amino-6-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
30 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-isobutyl-oxime,
31 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-phenoxy-ethyl)-oxime,
32 (5£)-4-amino-6-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
33 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime,
34 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
36 (5£)-4-amino-6-(3-bromo-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
37 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-ethyl-oxime,
38 (5£)-4-amino-6-[3-chloro-4-(pyridin-3-yloxy)-phenylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
44 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(4-methoxy-benzyl)-oxime,
45 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-methoxy-benzyl)-oxime, Cpd Names
46 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-benzyl-oxime,
47 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde 0-isopropyl-oxime,
48 (5£)-4-amino-6-(l -benzyl- lH-indazol-5 -ylamino)-pyrimidine-5- carbaldehyde 0-methyl-oxime,
49 (5£)-4-amino-6-(l -benzyl- lH-indazol-5 -ylamino)-pyrimidine-5- carbaldehyde 0-ethyl-oxime,
50 3-{5-[6-amino-(5£)-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]- indazol- 1 -ylmethyl} -benzonitrile,
51 3-{5-[6-amino-(5£)-5-(ethoxyimino-methyl)-pyrimidin-4-ylamino]-indazol- 1 -ylmethyl} -benzonitrile,
54 (5£)-4-amino-6-[l-(3-chloro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
55 (5£)-4-amino-6-[l-(3-chloro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime,
58 (5£)-4-amino-6-[2-(3-fluoro-benzyl)-lH-benzoimidazol-5-ylamino]- pyrimidine-5 -carbaldehyde O-ethyl-oxime,
59 (5£)-4-amino-6-(3-chloro-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
60 (5£)-4-amino-6-[2-(3-fluoro-benzyl)-lH-benzoimidazol-5-ylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
65 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-phenyl-oxime,
66 (5£)-4-amino-6-[l-(4-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
67 (5£)-4-amino-6-[l-(4-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime,
68 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-methoxy-ethyl)-oxime,
69 (5Z)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
70 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -dimethylamino-propyl)-oxime,
71 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2-methoxy-ethyl)-oxime,
74 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-2,3-dihydro-lH-indol-5-ylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime, Cpd Names
75 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5-carbaldehyde 0-(3-hydroxy-propyl)-oxime,
76 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
77 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde oxime,
78 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde 0-(2-morpholin-4-yl-ethyl)-oxime,
78* (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde 0-(2-morpholin-4-yl-ethyl)-oxime monohydrochloride salt,
79 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5-carbaldehyde oxime,
84 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde oxime,
85 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
87 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3-morpholin-4-yl-propyl)-oxime,
88 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde oxime,
91 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
92 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -piperidin- 1 -yl-propyl)-oxime,
93 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
94 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2 -piperidin- 1 -yl-ethyl)-oxime,
95 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2 -piperidin- 1 -yl-ethyl)-oxime,
96 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2 -piperidin- 1 -yl-ethyl)-oxime,
97 (5£)-4-amino-6-[3-chloro-4-(3,5-difluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde 0-methyl-oxime,
98 (5£)-4-amino-6-[3-chloro-4-(3,5-difluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde oxime,
99 (5£)-4-amino-6-[3-chloro-4-(3,5-difluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime, Cpd Names
100 (5£)-4-amino-6-[(15)-l-phenyl-ethylamino]-pyrimidine-5-carbaldehyde oxime,
101 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde 0-(2-morpholin-4-yl-ethyl)-oxime,
102 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde 0-(2-piperidin- 1 -yl-ethyl)-oxime,
111 (5£)-4-amino-6-(4-phenoxy-phenylamino)-pyrimidine-5-carbaldehyde oxime,
112 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(3-morpholin-4-yl-propyl)-oxime,
114 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-pyridin-2-ylmethyl-oxime,
115 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O- [3 -(2-methoxy-ethylamino)-propyl] -oxime,
118 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbonitrile,
119 Λ/-benzo[ 1 ,3]dioxol-5-ylmethyl-5-[(benzo[ 1 ,3]dioxol-5-ylmethylimino)- methyl]-pyrimidine-4,6-diamine,
120 4-amino-6-(4-methoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
121 4-amino-6-[(benzo[l,3]dioxol-5-ylmethyl)-amino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
122 4-amino-6-(3,4-dimethoxy-benzylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
123 4-amino-6-(4-phenoxy-benzylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
124 4-amino-6-(indan-l-ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime,
125 4-amino-6-(l,2,3,4-tetrahydro-naphthalen-l-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
126 4-amino-6-[l-(4-chloro-phenyl)-ethylamino]-pyrimidine-5-carbaldehyde O- methyl-oxime,
127 4-amino-6-[l-(4-methoxy-phenyl)-ethylamino]-pyrimidine-5-carbaldehyde O-methyl-oxime,
128 4-amino-6-(6-phenoxy-pyridin-3-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
129 4-amino-6-(6-morpholin-4-yl-pyridin-3-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime, Cpd Names
130 4-amino-6-(l,4-dioxo-l,2,3,4-tetrahydro-phthalazin-5-ylamino)-pyrimidine- 5-carbaldehyde 0-methyl-oxime,
131 4-amino-6-(2-fluoro-5-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
132 4-amino-6-(2,4,6-trimethyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
133 4-amino-6-(3-chloro-2-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
134 4-amino-6-(3-methylsulfanyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
135 4-amino-6-[3-(l-methoxyimino-ethyl)-phenylamino]-pyrimidine-5- carbaldehyde 0-methyl-oxime,
136 4-amino-6-(3,5-dimethyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
137 N- {4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-phenyl} - acetamide,
138 4-amino-6-phenylamino-pyrimidine-5 -carbaldehyde 0-methyl-oxime,
139 4-amino-6-(4-morpholin-4-yl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
140 4-amino-6-o-tolylamino-pyrimidine-5-carbaldehyde O-methyl-oxime,
141 4-amino-6-(3,4-difluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
142 4-amino-6-(3-fluoro-4-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
143 4-amino-6-(3,4-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
144 4-amino-6-(3-chloro-4-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
145 4-amino-6-[5-chloro-2-methyl-4-(2-oxo-2-phenyl-ethyl)-phenylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
146 4-amino-6-(3-ethyl-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
147 4-amino-6-(4-isopropyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
148 4-amino-6-(lH-indol-5-ylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
149 4-amino-6-(3-trifluoromethyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime, Cpd Names
150 4-amino-6-m-tolylamino-pyrimidine-5 -carbaldehyde O-methyl-oxime,
151 4-amino-6-(4-chloro-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
152 4-amino-6-(4-chloro-2-methyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
153 4-amino-6-(4-phenylamino-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
154 4-amino-6-(4-diethylamino-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
155 4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzoic acid methyl ester,
156 4-amino-6- [4-(methoxyimino-phenyl-methyl)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
157 4-(4-acetyl-phenylamino)-6-amino-pyrimidine-5 -carbaldehyde O-methyl- oxime,
158 4-amino-6- [4-( 1 -methoxyimino-ethyl)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
159 {4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-phenyl}- acetonitrile,
160 4-amino-6-(2-methoxy-4-phenylamino-phenylamino)-pyrimidine-5 - carbaldehyde O-methyl-oxime,
161 N-{4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-3- methoxy-phenyl} -acetamide,
162 4-amino-6-(4-cyclohexyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
163 4-amino-6-(naphthalen- 1 -ylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
164 4-amino-6-(4-chloro-naphthalen- 1 -ylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
165 4-amino-6-(2,4-difluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
166 4-amino-6-(2-methylsulfanyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
167 4-amino-6-(3 -fluoro-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
168 4-amino-6-(3,5-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime, Cpd Names
169 4-amino-6-(3,5-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
170 4-amino-6-(5 -chloro-2-methoxy-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl-oxime,
171 4-amino-6-(5-chloro-2-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
172 4-amino-6-(4-fluoro-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
173 4-amino-6-(biphenyl-4-ylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
174 4-amino-6-(4-methylsulfanyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
175 4-amino-6-(3,5-dimethoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
176 4-amino-6-(3,4,5-trimethoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
177 4-amino-6-(3 ,4-dimethoxy-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
178 4-amino-6-(5,6,7,8-tetrahydro-naphthalen-l-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
179 4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-pyrimidin- 2-yl-benzenesulfonamide,
180 3 - [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzoic acid ethyl ester,
181 {4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzyl} - phosphonic acid diethyl ester,
182 4-amino-6-(4-ethyl-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
183 4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-(3 ,5 - dimethyl-pyrazin-2-yl)-benzenesulfonamide,
184 4-amino-6-(2-methyl-benzothiazol-5-ylamino)-pyrimidine-5 -carbaldehyde O-methyl-oxime,
185 4-amino-6- [4-(4-methoxy-phenylamino)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
186 4-amino-6-(4-dimethylamino-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
187 4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-(2- diethylamino-ethyl)-benzamide, Cpd Names
188 4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzoic acid butyl ester,
189 4-amino-6-(indan-4-ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime,
190 4-amino-6-(4'-chloro-biphenyl-4-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
191 4-amino-6- [6-(4-fluoro-phenoxy)-pyridin-3 -ylamino]-pyrimidine-5 - carbaldehyde O-methyl-oxime,
192 4'-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-biphenyl-4- carboxylic acid methyl ester, and
193 N-(4-benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)- [l,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine.
A representative compound of formula (I) includes a compound selected from:
Cpd Names
1 (5£)-4-amino-6-(3-chloro-4-fluoro-phenylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
2 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
4 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino)- pyrimidine-5 -carbaldehyde O-methyl-oxime,
7 (5£)-4-amino-6-(3 -methoxy-4-phenoxy-phenylamino)-pyrimidine-5 - carbaldehyde O-methyl-oxime,
9 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
10 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime,
11 (5£)-4-amino-6-[ 1 -(3-fluoro-benzyl)- lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-allyl-oxime,
12 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-tert-butyl-oxime,
16 (5£)-4-amino-6-[(lS)-l-phenyl-ethylamino]-pyrimidine-5-carbaldehyde O- ethyl-oxime,
17 (5£)-4-amino-6-(lH-indol-5-ylamino)-pyrimidine-5 -carbaldehyde O-ethyl- oxime,
18 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino)- pyrimidine-5 -carbaldehyde O-ethyl-oxime, Cpd Names
19 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde 0-(2-morpholin-4-yl-ethyl)-oxime,
24 (5£)-4-amino-6-(4-phenoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
25 (5£)-4-amino-6-(4-benzyloxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
30 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde 0-isobutyl-oxime,
31 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde 0-(2-phenoxy-ethyl)-oxime,
32 (5£)-4-amino-6-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
33 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime,
34 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
36 (5£)-4-amino-6-(3-bromo-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
37 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-ethyl-oxime,
44 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(4-methoxy-benzyl)-oxime,
45 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-methoxy-benzyl)-oxime,
46 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-benzyl-oxime,
47 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-isopropyl-oxime,
48 (5£)-4-amino-6-(l -benzyl- lH-indazol-5 -ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
49 (5£)-4-amino-6-(l -benzyl- lH-indazol-5 -ylamino)-pyrimidine-5- carbaldehyde O-ethyl-oxime,
50 3-{5-[6-amino-(5£)-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]- indazol- 1 -ylmethyl} -benzonitrile,
51 3-{5-[6-amino-(5£)-5-(ethoxyimino-methyl)-pyrimidin-4-ylamino]-indazol- 1 -ylmethyl} -benzonitrile,
54 (5£)-4-amino-6-[l-(3-chloro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime, Cpd Names
55 (5£)-4-amino-6-[l-(3-chloro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde 0-ethyl-oxime,
60 (5£)-4-amino-6-[2-(3-fluoro-benzyl)-lH-benzoimidazol-5-ylamino]- pyrimidine-5 -carbaldehyde 0-methyl-oxime,
70 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -dimethylamino-propyl)-oxime,
71 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde 0-(2-methoxy-ethyl)-oxime,
75 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(3-hydroxy-propyl)-oxime,
76 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
78 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
78* (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime monohydrochloride salt,
79 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde oxime,
84 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde oxime,
85 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
87 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3-morpholin-4-yl-propyl)-oxime,
88 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde oxime,
91 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
92 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -piperidin- 1 -yl-propyl)-oxime,
93 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
94 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2 -piperidin- 1 -yl-ethyl)-oxime,
101 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
102 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2 -piperidin- 1 -yl-ethyl)-oxime, Cpd Names
118 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbonitrile,
120 4-amino-6-(4-methoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
124 4-amino-6-(indan-l-ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime,
125 4-amino-6-(l,2,3,4-tetrahydro-naphthalen-l-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
126 4-amino-6-[l-(4-chloro-phenyl)-ethylamino]-pyrimidine-5-carbaldehyde O- methyl-oxime, and
128 4-amino-6-(6-phenoxy-pyridin-3-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime.
A representative compound of formula (I) includes a compound selected from:
Cpd Names
2 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde 0-methyl-oxime,
10 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime,
11 (5£)-4-amino-6-[ 1 -(3-fluoro-benzyl)- lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-allyl-oxime,
75 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5-carbaldehyde O-(3-hydroxy-propyl)-oxime,
78 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
78* (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime monohydrochloride salt,
79 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5-carbaldehyde oxime,
88 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde oxime,
91 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
93 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
94 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2-piperidin- 1 -yl-ethyl)-oxime,
101 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime, Cpd Names
102 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde 0-(2-piperidin- 1 -yl-ethyl)-oxime,
118 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbonitrile,
125 4-amino-6-(l,2,3,4-tetrahydro-naphthalen-l-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime, and
128 4-amino-6-(6-phenoxy-pyridin-3-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime.
A representative compound of formula (I) includes a compound selected from:
Cpd Names
127 4-amino-6-[l-(4-methoxy-phenyl)-ethylamino]-pyrimidine-5-carbaldehyde 0-methyl-oxime,
130 4-amino-6-(l,4-dioxo-l,2,3,4-tetrahydro-phthalazin-5-ylamino)-pyrimidine- 5-carbaldehyde O-methyl-oxime,
131 4-amino-6-(2-fluoro-5-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
132 4-amino-6-(2,4,6-trimethyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
133 4-amino-6-(3-chloro-2-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
134 4-amino-6-(3-methylsulfanyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
135 4-amino-6-[3-(l-methoxyimino-ethyl)-phenylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
136 4-amino-6-(3,5-dimethyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
137 N- {4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-phenyl} - acetamide,
138 4-amino-6-phenylamino-pyrimidine-5 -carbaldehyde 0-methyl-oxime,
139 4-amino-6-(4-morpholin-4-yl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
140 4-amino-6-o-tolylamino-pyrimidine-5-carbaldehyde O-methyl-oxime,
141 4-amino-6-(3,4-difluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
142 4-amino-6-(3-fluoro-4-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime, Cpd Names
143 4-amino-6-(3,4-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
144 4-amino-6-(3-chloro-4-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
145 4-amino-6-[5-chloro-2-methyl-4-(2-oxo-2-phenyl-ethyl)-phenylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
146 4-amino-6-(3-ethyl-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
147 4-amino-6-(4-isopropyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
148 4-amino-6-(lH-indol-5-ylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
149 4-amino-6-(3-trifluoromethyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
150 4-amino-6-m-tolylamino-pyrimidine-5 -carbaldehyde O-methyl-oxime,
151 4-amino-6-(4-chloro-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
152 4-amino-6-(4-chloro-2-methyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
153 4-amino-6-(4-phenylamino-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
154 4-amino-6-(4-diethylamino-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
155 4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzoic acid methyl ester,
156 4-amino-6- [4-(methoxyimino-phenyl-methyl)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
157 4-(4-acetyl-phenylamino)-6-amino-pyrimidine-5 -carbaldehyde O-methyl- oxime,
158 4-amino-6- [4-( 1 -methoxyimino-ethyl)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
159 {4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-phenyl}- acetonitrile,
160 4-amino-6-(2-methoxy-4-phenylamino-phenylamino)-pyrimidine-5 - carbaldehyde O-methyl-oxime,
161 N-{4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-3- methoxy-phenyl} -acetamide, Cpd Names
162 4-amino-6-(4-cyclohexyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
163 4-amino-6-(naphthalen- 1 -ylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
164 4-amino-6-(4-chloro-naphthalen- 1 -ylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
165 4-amino-6-(2,4-difluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
166 4-amino-6-(2-methylsulfanyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
167 4-amino-6-(3 -fluoro-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
168 4-amino-6-(3,5-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
169 4-amino-6-(3,5-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
170 4-amino-6-(5 -chloro-2-methoxy-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl-oxime,
171 4-amino-6-(5-chloro-2-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
172 4-amino-6-(4-fluoro-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
173 4-amino-6-(biphenyl-4-ylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
174 4-amino-6-(4-methylsulfanyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
175 4-amino-6-(3,5-dimethoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
176 4-amino-6-(3,4,5-trimethoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
177 4-amino-6-(3 ,4-dimethoxy-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
178 4-amino-6-(5,6,7,8-tetrahydro-naphthalen-l-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
179 4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-pyrimidin- 2-yl-benzenesulfonamide,
180 3 - [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzoic acid ethyl ester, Cpd Names
181 {4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzyl} - phosphonic acid diethyl ester,
182 4-amino-6-(4-ethyl-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
183 4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-(3 ,5 - dimethyl-pyrazin-2-yl)-benzenesulfonamide,
184 4-amino-6-(2-methyl-benzothiazol-5-ylamino)-pyrimidine-5 -carbaldehyde O-methyl-oxime,
185 4-amino-6- [4-(4-methoxy-phenylamino)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
186 4-amino-6-(4-dimethylamino-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
187 4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-(2- diethylamino-ethyl)-benzamide,
188 4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzoic acid butyl ester,
189 4-amino-6-(indan-4-ylamino)-pyrimidine-5 -carbaldehyde O-methyl-oxime,
190 4-amino-6-(4'-chloro-biphenyl-4-ylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
191 4-amino-6- [6-(4-fluoro-phenoxy)-pyridin-3 -ylamino]-pyrimidine-5 - carbaldehyde O-methyl-oxime,
192 4'-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-biphenyl-4- carboxylic acid methyl ester, and
193 N-(4-benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)- [l,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine.
Synthetic Methods
Representative compounds of the present invention can be synthesized in accordance with the general synthetic schemes described below and are illustrated more particularly in the specific synthetic examples that follow. The general schemes and specific examples are offered by way of illustration; the invention should not be construed as being limited by the chemical reactions and conditions expressed.
Except where indicated, starting materials and intermediates used in the schemes and examples are prepared by known methodologies well within the ordinary skill of persons versed in the art. No attempt has been made to optimize the yields obtained in any of the example reactions. One skilled in the art would also know how to increase such yields through routine variations in materials, solvents, reagents, reaction conditions and the like.
Compounds of the present invention can also be useful as intermediates for conversion to other compounds representative of the present invention via functional group transformations.
DSC analysis was were conducted on a TA Instruments QlOO. The calibration standard was indium. A sample (approximately 2 mg) was placed into a TA DSC pan and weight was recorded. Crimped pans were used for analysis and the samples were heated under nitrogen (50cc/min) at a rate of 10°C/min, up to a final temperature of 25O0C. The data were processed using a thermal analyzer (Universal Analyzer 2000, TA Instruments).
The terms used in describing the invention are commonly used and known to those skilled in the art. When used herein, the following abbreviations have the indicated meanings:
Abbreviation Meaning
AcOH acetic acid
Cpd compound
DCM dichloromethane
DMF N,N-dimethylformamide
DMSO dimethyl sulfoxide
EDCI l-(3-dimethylaminopropyl)-3-ethyl- carbodiimide hydrochloride
EtOAc ethyl acetate
EtOH ethanol h/hr(s)/min(s) hour(s)/min(s)
LCMS Rt High Pressure Liquid Chromatography Mass Spectrum Retention Time
MeOH methanol
RT/rt/r.t. room temperature
TEA or Et3N triethylamine
THF tetrahydrofuran Scheme A
Figure imgf000092_0001
A solution of Compound Al (in a suitable solvent such as toluene and the like) is reacted with a volume of NH3 gas under suitable conditions to provide a Compound
A2.
Figure imgf000092_0002
A mixture of Compound A2 (in a suitable solvent such as DMSO and the like) and a reagent (such as triethylamine and the like) is reacted with a Compound A3 to provide a Compound A4.
Alternatively, a mixture of Compound A2 (in a suitable solvent such as 2- methoxy-ethanol and the like) is reacted with Compound A3 in the presence of a catalytic amount of acid (such as aqueous HCl) to provide Compound A4.
Figure imgf000092_0003
A mixture of Compound A4 (in a suitable solvent such as DMSO and the like) is reacted with NH2OH hydrochloride to provide a Compound A5, representative of a compound of formula (I).
Figure imgf000093_0001
A mixture of Compound A5 (in a suitable solvent such as DMF and the like) and a basic reagent (such as cesium carbonate and the like) is reacted with a Compound A6 (wherein Qi is a leaving group such as a halogen atom and the like) to provide a Compound A7, representative of a compound of formula (I).
Figure imgf000093_0002
A solution of Compound A7 (in a suitable solvent such as DMF and the like) is reacted with a Compound A8 (wherein Q2 is a leaving group such as a halogen atom and the like) to provide a Compound A9, representative of a compound of formula (I).
Figure imgf000093_0003
The Compound A9 is metabolized to provide a Compound AlO, representative of a compound of formula (I).
Figure imgf000094_0001
A mixture of Compound A4 (in a suitable solvent such as DMSO and the like) is reacted with Compound All to provide a Compound A7, representative of a compound of formula (I).
Alternatively, a mixture of Compound A4 (in a suitable solvent such as 2- methoxy-ethanol and the like) is reacted with a dihydrochloride salt of Compound All in the presence of a base (such as NaOH) to provide Compound A7.
R7
NH2
Figure imgf000094_0002
A solution of Compound Al (in a suitable solvent such as toluene and the like) is reacted with a Compound A12 in a suitable solvent such as THF under suitable conditions to provide a Compound A13.
Figure imgf000095_0001
A mixture of Compound A13 (in a suitable solvent such as DMSO and the like) and a reagent (such as triethylamine and the like) is reacted with a Compound A3 to provide a Compound A14.
Figure imgf000095_0002
A mixture of Compound A14 (in a suitable solvent such as DMSO and the like) is reacted with Compound All to provide a Compound A9, representative of a compound of formula (I).
Scheme B
Figure imgf000095_0003
A mixture of Compound Bl (in a suitable solvent such as THF and the like) and a reagent (such as triethylamine and the like) is reacted with a Compound A3 to provide a Compound B2.
Figure imgf000096_0001
A suspension of Compound B2 in N(R2)H2 (in a suitable solvent such as MeOH and the like) is reacted to provide a Compound B3, representative of a compound of formula (I).
Scheme C
Figure imgf000096_0002
A mixture of Compound A14 (in a suitable solvent such as a mixture of THF and MeOH and the like) is reacted with a reagent mixture (such as a mixture OfMnO2, NaCN, AcOH and the like) to provide a Compound Cl.
Figure imgf000096_0003
A suspension of Compound Cl (in a solvent such as 100% EtOH and the like) was treated with hydrazine to provide a Compound C2.
Figure imgf000097_0001
A mixture of Compound C2 is reacted with a Compound C3 and a reagent mixture (such as EDCI in DMF and the like) to provide a Compound C4.
Figure imgf000097_0002
A solution of Compound C4 (in a solvent such as DCM and the like) is reacted with a reagent mixture (such as Et3N and toluene sulfonyl chloride and the like) to provide a Compound C5, representative of a compound of formula (I).
Example 1
(5E)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)- pyrimidine-5 -carbaldehyde 0-(2-morpholin-4-yl-ethyl)-oxime
(Cpd 78)
Figure imgf000097_0003
NH3 (g) was blown through a solution of 4,6-dichloro-pyrimidine-5- carbaldehyde Compound Ia (50 g, 282.5 mmol) in toluene (565 mL, 0.5M) for 3 mins using a 12C glass frit, then the mixture was warmed at 60 0C with stirring for 30 min. NH3 (g) was blown through the reaction mixture a second time for 3 min and the reaction was heated for 30 mins. NH3 (g) was blown through the reaction mixture a third time for 3 min and the reaction was heated for a final 20 mins. The reaction mixture was diluted with H2O (1 L), and extracted with EtOAc (1 x 750 mL, 3 x 500 mL). The organic extracts were washed with brine (4 x) and dried (Na2SO4), then concentrated to afford 4-amino-6-chloro-pyrimidine-5-carbaldehyde Compound Ib (38.5 g, 87%) as a yellow solid. 1H NMR (300 MHz, DMSO-J6) δ 10.27 (s, IH), 8.74 (br s, IH), 8.58 (br s, IH), 8.42 (s, IH).
Figure imgf000098_0001
4-benzyloxy-3-chloro-phenylamine Compound Ic (8.9 g, 38 mmol) was added to a solution of Compound Ib (6.Og, 38 mmol) and Et3N (10.6 mL, 76 mmol) in DMSO (38 mL, IM). The mixture was warmed at 100 0C for 3 hrs. The reaction mixture was cooled, then diluted with H2O and extracted with EtOAc (3 x). The organic extract was washed with H2O (4 x), concentrated onto SiO2 (30 g) and purified via column chromatography (Horizon, 65+, 60 to 100% EtOAc / hexanes) to afford 4- amino-6-(4-benzyloxy-3 -chloro-phenylamino)-pyrimidine-5 -carbaldehyde Compound Id (8.29 g, 61%) as a yellow solid. 1H NMR (400 MHz, CD3OD, warm) δ 10.15 (s, IH), 8.05 (s, IH), 7.77 (d, J = 2.4 Hz, IH), 7.48 (d, J = 7.6 Hz, 2H), 7.38 (m, 4H), 7.11 (d, J = 8.8 Hz, IH), 5.18, (s, 2H).
A solution of Compound Id (3.88 g, 10.9 mmol) and NH2OH hydrochloride (3.02 g, 43.6 mmol) was warmed in DSMO at 90 0C for 4 hours. The reaction mixture was cooled, diluted with H2O and extracted with EtOAc (3 x). The combined organic extracts were washed with H2O (4 x), then dried (Na2SO4) and concentrated onto SiO2 (12 g). The residue was purified via column chromatography (Horizon 65 +, 70 to 100 % EtOAc / hexanes) to provide 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)- pyrimidine-5-carbaldehyde oxime Compound Ie (2.65 g (66 %) as a yellow solid. 1H NMR (300 MHz, DMSO-J6) δ 11.26 (s, IH), 9.82 (s, IH), 8.64 (s, IH), 8.03 (s, IH), 7.81 (d, J = 2.4 Hz, IH), 7.45 (m, 6H), 7.23 (m, 3H), 5.20 (s, 2H).
Figure imgf000099_0002
4-(2-chloro-ethyl)-morpholine hydrochloride (1.6 g, 8.9 mmol) was added to a suspension of Compound Ie (3.3 g, 8.9 mmol) and cesium carbonate (8.6 g, 26.7 g) in DMF (90 niL, 0.1 M). The mixture was warmed at 50 0C for 6 hrs. The reaction mixture was cooled, then diluted with H2O and extracted with EtOAc (3 x). The combined organic extracts were washed with H2O (4 x), then dried (Na2SO4) and concentrated onto SiO2 (12 g). The residue was purified via column chromatography (Horizon 40+M, 0-6% MeOH/DCM) to provide Compound 78 (3.58 g, 83%) as a yellow solid. 1H NMR (300 MHz, DMSO-J6) δ 9.60 (s, IH), 8.72 (s, IH), 8.03 (s, IH), 7.83 (d, J = 2.7 Hz, IH), 7.49-7.39 (m, 6H), 7.28 (s, 2H), 7.18 (d, J = 9.0 Hz, IH), 5.20 (s, 2H), 4.30 (t, J = 5.6 Hz, 2H), 3.58 (m, 4H), 2.66 (t, J = 5.6 Hz, 2H), 2.47 (m, 4H); MS (ESI) m/z 383 (MH+); DSC Thermogram: single endothermic peak at 175 0C due to melting with onset and peak temperatures of 174.66 0C and 176.28 0C, respectively, and an enthalpy of 142.9 J/g.
Compound 78 was further conjugated with monohydrochloride HCl to provide Compound 78 as a monohydrochloride salt. 1H NMR (300 MHz, DMSO-J6) δ 10.78 (br s, IH), 9.52 (s, IH), 8.79 (s, IH), 8.06 (s, IH), 7.84 (d, J = 2.7 Hz, 1 H), 7.51-7.19 (m, 9 H), 7.20 (d, J = 9 Hz, IH), 5.22 (s, 2H), 4.56 (br s, 2 H), 4.03-3.82 (m, 4H), 3.58- 3.18 (m, 13H); Anal. Calcd for C24H28Cl2N6O3: C, 55.50; H, 5.43; N, 16.18; Cl, 13.65; Found: C, 55.08; H, 5.41; N, 15.94; Cl, 13.17.
Using the procedure of Example 1, other compounds representative of the present invention were prepared:
Cpd Name and Data
1 (5£)-4-amino-6-(3-chloro-4-fluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime
1H NMR (OMSO-d6) δ 9.68 (br, IH), 8.71 (br, IH), 8.06 (s, IH), 7.99 (dd, J = 6.78 and 2.80 Hz, IH), 7.49 (m, IH), 7.35 (br, 2H), 7.34 (m, IH), 3.96 (s, 3H). LC-MS Rt = 1.08 min, m/z 296.3 (MH+)
2 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (OMSO-d6) δ 9.75 (s, IH), 8.73 (s, IH), 8.09 (t, J = 0.86 Hz, IH), 8.06 (d, J = 1.86 Hz, IH), 8.00 (s, IH), 7.64 (d, J = 9.07 Hz, IH), 7.44 (dd, J = 8.88 and 1.93 Hz, IH), 7.34 (m, IH), 7.21 (s, 2H), 7.09 (m, IH), 7.04 (m, 2H), 5.67 (s, 2H), 3.95 (s, 3H). LC-MS Rt = 1.19 min, m/z 392.4 (MH+)
3 (5£)-4-amino-6-(3-chloro-4-fluoro-benzylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 310.1 (MH+) Cpd Name and Data
4 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (CD3OD) δ 8.56 (s, IH), 7.96 (s, IH), 7.68 (d, J = 2.50 Hz, IH), 7.39 (td, J = 7.98 and 5.58 Hz, IH), 7.28 (dd, J = 8.85 and 2.61 Hz, 2 H), 7.23 (m, IH), 7.08 (d, J = 8.92 Hz, IH), 7.02 (m, IH), 5.18 (s, 2H), 3.98 (s, 3H). LC-MS Rt = 1.41 min, m/z 402.1 (MH+)
5 (5£)-4-amino-6-[2-(3-fluoro-benzyl)-2H-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (CDCl3) δ 9.60 (s, IH), 8.34 (d, J = 0.50 Hz, IH), 8.18 (s, IH), 8.03 (dd, J = 1.83 and 0.45 Hz, IH), 7.91 (br, IH), 7.71 (dd, J = 9.20 and 0.65 Hz, IH), 7.31 (m, IH), 7.23 (m, IH), 7.02 (dd, J = 7.88 and 1.96 Hz, 2H), 6.96 (m, IH), 5.72 (br, 2H), 5.58 (s, 2H), 4.03 (s, 3H). LC-MS Rt = 1.12 min, m/z 392.2 (MH+)
6 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-2-oxo-ethyl)-oxime
1H NMR (CD3OD) δ 8.73 (s, IH), 8.13 (d, J = 0.92 Hz, IH), 8.12 (s, IH), 7.94 (dd, J = 1.91 and 0.66 Hz, IH), 7.63 (d, J = 9.0 Hz, IH), 7.44 (dd, J = 8.92 and 1.97 Hz, IH), 7.32 (dt, J = 7.98 and 5.75 Hz, IH), 7.02 (m, 2H), 6.89 (dt, J = 9.66 and 1.79 Hz, IH), 5.69 (s, 2H), 5.00 (s, 2H), 3.67 (t, J = 4.52 Hz, 2H), 3.60 (m, 4H), 3.53 (t, J = 4.85 Hz, 2H). LC-MS Rt = 1.00 min, m/z 505.1 (MH+)
7 (5£)-4-amino-6-(3-methoxy-4-phenoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime
1H NMR (CDCl3) δ 9.40 (s, IH), 8.30 (s, IH), 8.22 (s, IH), 7.51 (t, J = 1.24 Hz, IH), 7.29 (m, 2H), 7.03 (tt, J = 7.31 and 1.11 Hz, IH), 6.96 (m, 4H), 5.36 (s, 2H), 4.03 (s, 3H), 3.86 (s, 3H). LC-MS Rt = 1.27 min, m/z 366.1 (MH+)
8 (5£)-4-amino-6-(3-methoxy-4-phenoxy-phenylamino)-pyrimidine-5-carbaldehyde O-(2-morpholin-4-yl-2-oxo-ethyl)-oxime
1H NMR (CDCl3) δ 9.33 (br, IH), 8.46 (s, IH), 8.22 (s, IH), 7.49 (d, J = 2.49 Hz, IH), 7.28 (td, J = 7.44 and 1.23 Hz, 2H), 7.13 (dd, J = 8.68 and 2.46 Hz, IH), 7.03 (tt, J = 7.34 and 1.07 Hz, IH), 6.95 (m, 3H), 5.50 (br, 2H), 4.84 (s, 2H), 3.88 (s, 3H), 3.68 (t, J = 4.80 Hz, 2H), 3.64 (4H), 3.53 (t, J = 4.80 Hz, 2H). LC-MS Rt = 1.06 min, m/z 379.2 (MH+)
9 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime
1H NMR (CDCl3) δ 9.34 (s, IH), 8.27 (s, IH), 8.18 (s, IH), 7.66 (d, J = 2.60 Hz, IH), 7.46 (m, 2H), 7.32-7.42 (4H), 6.94 (d, J = 8.87 Hz, 1 H), 5.33 (br, 2H), 5.16 (s, 2H), 4.01 (s, 3H). LC-MS Rt = 1.40 min, m/z 384.1 (MH+)
10 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime
1H NMR (CDCl3) δ 10.39 (s, IH), 8.42 (s, IH), 8.10 (m, IH), 8.08 (s, IH), 7.89 (s, IH), 7.35 (d, J = 1.3 Hz, IH), 7.24-7.33 (4H), 6.83-7.01 (3H), 5.60 (s, 2H), 4.28 (q, J = 7.06 Hz, 2H), 1.37 (t, J = 7.04 Hz, 3H). LC-MS Rt = 1.27 min, m/z 406.1 (MH+) Cpd Name and Data
11 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-allyl-oxime
1H NMR (CDCl3) δ 9.52 (br, IH), 8.36 (s, IH), 8.17 (s, IH), 8.04 (d, J = 0.88 Hz, IH), 7.97 (m, IH), 7.41 (dd, J = 9.05 and 2.1 Hz, IH), 7.23-7.32 (2H), 6.83-6.98 (3H), 6.06 (m, IH), 5.58 (s, 2H), 5.45 (br, 2H), 5.39 (dq, J = 17.29 and 1.52 Hz, IH), 5.31 (m, IH), 4.69 (dt, J = 5.98 and 1.35 Hz, 2H). LC-MS Rt = 1.32 min, m/z 418.1 (MH+)
12 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-tert-butyl-oxime
1H NMR (CDCl3) δ 8.30 (s, IH), 8.18 (s, IH), 8.04 (m, IH), 8.00 (m, IH), 7.21- 7.36 (4H), 6.84-6.98 (3H), 5.58 (s, 2H), 1.41 (s, 9H). LC-MS Rt = 1.45 min, m/z 434.1 (MH+)
13 (5£)-4-amino-6-[3-methyl-4-(pyridin-3-yloxy)-phenylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (CDCl3) δ 9.42 (br, IH), 8.36 (dd, J = 2.81 and 0.60 Hz, IH), 8.31 (dd, J = 4.41 and 1.60 Hz, IH), 8.30 (s, IH), 8.20 (s, IH), 7.48 (d, J = 2.37 Hz, IH), 7.40 (dd, J = 8.64 and 2.74 Hz, IH), 7.23 (ddd, J = 8.39, 4.37, and 0.80 Hz, IH), 7.17 (ddd, J = 8.40, 2.75, and 1.65 Hz, IH), 6.93 (d, J = 8.68 Hz, IH), 5.45 (br, 2H), 4.00 (s, 3H), 2.24 (s, 3H). LC-MS Rt = 0.55 min, m/z 351.1 (MH+)
14 (5£)-4-amino-6-[(lR)-l-phenyl-ethylamino]-pyrimidine-5-carbaldehyde O-ethyl- oxime
1H NMR (CDCl3) δ 8.24 (s, IH), 8.09 (s, IH), 7.71 (d, J = 6.85 Hz, IH), 7.31-7.38 (3H), 7.22-7.28 (2H), 5.45 (m, IH), 5.29 (br, 2H), 4.18 (q, J = 7.10 Hz, 2H), 1.57 (d, J = 6.85 Hz, 3H), 1.31 (t, J = 7.05 Hz, 3H). LC-MS Rt = 1.19 min, m/z 286.0 (MH+)
15 (52)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde oxime
1H NMR (CD3OD) δ 8.54 (s, IH), 8.05 (d, J = 0.87 Hz, IH), 7.92 (dd, J = 1.90 and 0.72 Hz, IH), 7.90 (s, IH), 7.51 (dt, J = 8.89 and 0.81 Hz, IH), 7.41 (dd, J = 8.96 and 1.93 Hz, IH), 7.30 (td, J = 7.94 and 5.84 Hz, IH), 7.01 (m, IH), 6.97 (m, IH), 6.88 (dt, J = 9.79 and 2.27 Hz, IH), 5.65 (s, 2H). LC-MS Rt = 0.98 min, m/z 378.1 (MH+)
16 (5£)-4-amino-6-[(l S)- 1 -phenyl-ethylamino]-pyrimidine-5-carbaldehyde O-ethyl- oxime
1H NMR (CDCl3) δ 8.92 (d, J = 7.11 Hz, IH), 8.42 (s, IH), 8.02 (s, IH), 7.28-7.39 (5H), 7.23 (br, 2H), 5.47 (m, IH), 4.17 (q, J = 7.02 Hz, 2H), 1.61 (d, J = 6.87 Hz, 3H), 1.28 (t, J = 7.04 Hz, 3H). LC-MS Rt = 1.19 min, m/z 286.1 (MH+)
17 (5£)-4-amino-6-(lH-indol-5-ylamino)-pyrimidine-5-carbaldehyde O-ethyl-oxime
1H NMR (CDCl3) δ 9.42 (br, IH), 8.33 (s, IH), 8.15 (s, IH), 7.76 (d, J = 2.03 Hz, IH), 7.39 (d, J = 8.69 Hz, IH), 7.24 (m, 2H), 6.55 (m, IH), 5.65 (br, 2H), 4.26 (q, J = 7.05 Hz, 2H), 1.37 (t, J = 7.08 Hz, 3H). LC-MS Rt = 0.96 min, m/z 297.0 (MH+) Cpd Name and Data
18 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino)-pyrimidine-5- carbaldehyde O-ethyl-oxime
1H NMR (CDCl3) δ 9.56 (br, IH), 8.30 (s, IH), 8.17 (s, IH), 7.66 (d, J = 2.64 Hz, IH), 7.34 (m, 2H), 7.21 (m, 2H), 7.02 (td, J = 8.20 and 2.37 Hz, IH), 6.93 (d, J = 8.81 Hz, IH), 5.62 (br, 2H), 5.14 (s, 2H), 4.27 (q, J = 7.05 Hz, 2H), 1.37 (t, J = 7.07 Hz, 3H). LC-MS Rt = 1.56 min, m/z 416.1 (MH+)
19 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime
1H NMR (CD3OD) δ 8.63 (s, IH), 8.05 (d, J = 0.91 Hz, IH), 7.92 (m, 2H), 7.50 (m, IH), 7.42 (dd, J = 8.95 and 1.92 Hz, IH), 7.30 (m, IH), 7.00 (m, 2H), 6.87 (m, IH), 5.65 (s, 2H), 4.38 (t, J = 5.45 Hz, 2H), 3.71 (t, J = 4.65 Hz, 4H), 2.83 (t, J = 5.46 Hz, 2H), 2.64 (t, J = 4.54 Hz, 4H). LC-MS Rt = 0.84 min, m/z 491.2 (MH+)
20 (5£)-4-amino-6-(indan-5-ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime
1H NMR (CDCl3) δ 9.51 (br, IH), 8.33 (s, IH), 8.14 (s, IH), 7.40 (m, IH), 7.20 (m, 2H), 6.00 (br, 2H), 4.01 (s, 3H), 2.96 (t, J = 7.79 Hz, 2H), 2.90 (t, J = 7.35 Hz, 2H), 2.10 (m, 2H). LC-MS Rt = 1.15 min, m/z 284.1 (MH+)
21 (5£)-4-amino-6-(4-difluoromethoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime
1H NMR (CDCl3) δ 10.06 (br, IH), 8.40 (s, IH), 8.14 (s, IH), 7.52 (d, J = 8.93 Hz, 2H), 7.16 (d, J = 8.97 Hz, 2H), 6.74 (br, 2H), 6.38 (d, J = 73.68 Hz, IH), 4.04 (s, 3H). Rt = 1.03 min, m/z 310.1 (MH+)
22 (5£)-4-amino-6-(lH-indazol-5-ylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime
1H NMR (CDCl3) δ 8.61 (s, IH), 8.02 (d, J = 0.96 Hz, IH), 7.94 (s, IH), 7.92 (dd, J = 1.96 and 0.81 Hz, IH), 7.53 (dt, J = 8.94 and 0.81 Hz, IH), 7.42 (dd, J = 8.91 and 1.96 Hz, IH), 4.00 (s, 3H). LC-MS Rt = 0.60 min, m/z 284.0 (MH+)
23 (5£)-4-amino-6-(benzo[l,3]dioxol-5-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime
1H NMR (CDCl3) δ 10.20 (br, IH), 8.33 (s, IH), 8.10 (s, IH), 7.07 (m, IH), 6.92 (d, J = 3.14 Hz, IH), 6.82 (br, 2H), 6.81 (d, J = 1.85 Hz, IH), 6.03 (s, 2H), 4.04 (s, 3H). LC-MS Rt = 0.65 min (22.93%), m/z 288.1 (MH+); Rt = 0.85 min (77.07%), m/z 288.0 (MH+)
24 (5£)-4-amino-6-(4-phenoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime
1H NMR (CDCl3) δ 8.36 (s, IH), 8.12 (s, IH), 7.43 (m, 2H), 7.36 (m, 3H), 7.14 (m, IH), 7.04 (m, 3H), 4.05 (s, 3H). LC-MS Rt = 1.30 min, m/z 336.1 (MH+)
25 (5£)-4-amino-6-(4-benzyloxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime
1H NMR (CDCl3) δ 9.31 (br, IH), 8.31 (s, IH), 8.15 (s, IH), 7.28-7.46 (7H), 6.99 (m, 2H), 5.54 (br, 2H), 5.07 (s, 2H), 4.00 (s, 3H). LC-MS Rt = 1.29 min, m/z 350.2 (MH+) Cpd Name and Data
26 (5£)-4-amino-6-(4-sec-butyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime
1H NMR (CDCl3) δ 9.72 (s, IH), 8.33 (s, IH), 8.16 (s, IH), 7.43 (d, J = 8.42 Hz, 2H), 7.20 (d, J = 8.44 Hz, IH), 6.21 (br, 2H), 4.02 (s, 3H), 2.59 (m, IH), 1.58 (dq, J = 7.28 and 7.25 Hz, 2H), 1.23 (d, J = 6.94 Hz, 3H), 0.83 (t, J = 7.31 Hz, 3H). LC- MS Rt = 1.35 min, m/z 300.2 (MH+)
27 (5£)-4-amino-6-(4-tert-butyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime
1H NMR (CDCl3) δ 8.36 (s, IH), 8.14 (s, IH), 7.42 (s, 4H), 4.02 (s, 3H), 1.33 (s, 9H). LC-MS Rt = 1.32 min, m/z 300.1 (MH+)
28 (5£)-4-amino-6-(3-benzyloxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime
1H NMR (CDCl3) δ 9.73 (br, IH), 8.32 (s, IH), 8.16 (s, IH), 7.24-7.47 (7H), 7.06 (m, IH), 6.79 (ddd, J = 8.0, 2.33 and 0.65 Hz, IH), 6.12 (br, 2H), 5.09 (s, 2H), 4.02 (s, 3H). LC-MS Rt = 1.32 min, m/z 350.1 (MH+)
29 (5£)-4-amino-6-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-pyrimidine- 5-carbaldehyde O-methyl-oxime
1H NMR (CDCl3) δ 9.41 (s, IH), 8.31 (s, IH), 8.25 (dd, J = 2.59 and 0.75 Hz, IH), 8.19 (s, IH), 7.45 (d, J = 2.61 Hz, IH), 7.35 (dd, J = 8.59 and 2.71 Hz, IH), 7.12 (dd, J = 8.52 and 2.67 Hz, IH), 7.09 (t, J = 8.43 Hz, IH), 6.87 (d, J = 8.62 Hz, IH), 5.53 (br, 2H), 4.02 (s, 3H), 2.50 (s, 3H), 2.26 (s, 3H). LC-MS Rt = 0.58 min, m/z 365.1 (MH+)
30 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde 0-isobutyl-oxime
1H NMR (CD3OD) δ 8.62 (s, IH), 8.05 (d, J = 0.97 Hz, IH), 7.92 (dd, J = 1.91 and 0.78 Hz, IH), 7.91 (s, IH), 7.52 (dt, J = 9.01 and 0.83 Hz, IH), 7.41 (dd, J = 8.98 and 1.95 Hz, IH), 7.30 (m, IH), 6.99 (m, 2H), 6.87 (m, IH), 5.66 (s, 2H), 3.97 (d, J = 6.72 Hz, 2H), 2.05 (m, IH), 0.99 (d, J = 6.73 Hz, 6H). LC-MS Rt = 1.67 min, m/z 485.1 (MH+)
31 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-phenoxy-ethyl)-oxime
1H NMR (CDCl3) δ 8.47 (s, IH), 8.10 (m, IH), 8.05 (s, IH), 7.85 (m, IH), 7.21- 7.36 (5H), 6.84-7.01 (6H), 5.59 (s, 2H), 4.58 (t, J = 4.42 Hz, 2H), 4.28 (t, J = 4.30 Hz, 2H). LC-MS Rt = 1.47 min, m/z 498.2 (MH+)
32 (5£)-4-amino-6-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (OMSO-d6) δ 9.58 (s, IH), 8.69 (s, IH), 8.58 (m, IH), 8.02 (s, IH), 7.87 (td, J = 8.21 and 1.72 Hz, 2H), 7.56 (d, J = 7.89 Hz, IH), 7.37 (m, 2H), 7.27 (br, 2H), 7.17 (d, J = 9.08 Hz, IH), 5.25 (s, 2H), 3.94 (s, 3H). LC-MS Rt = 0.73 min, m/z 385.1 (MH+) Cpd Name and Data
33 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime
1H NMR (CDCl3) δ 9.68 (br, IH), 8.34 (s, IH), 8.12 (s, IH), 7.76 (br, IH), 7.28 (m, IH), 7.22 (m, 2H), 7.16 (d, J = 3.19 Hz, IH), 6.96 (dt, J = 8.74 and 2.75 Hz, IH), 6.89 (m, IH), 6.77 (dt, J = 9.55 and 2.27 Hz, IH), 6.56 (d, J = 3.13 Hz, IH), 6.11 (br, 2H), 5.32 (s, 2H), 4.26 (q, J = 7.09 Hz, 2H), 1.36 (t, J = 7.06 Hz, 3H). LC-MS Rt = 1.44 min, m/z 405.2 (MH+)
34 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (CD3OD) δ 8.59 (s, IH), 7.85 (s, IH), 7.64 (dd, J = 2.02 and 0.57 Hz, IH), 6.91-6.98 (3H), 7.11 (dd, J = 8.74 and 2.01 Hz, IH), 6.93 (m, 2H), 6.78 (dt, J = 9.95 and 2.18 Hz, IH), 6.51 (dd, J = 3.16 and 0.82 Hz, IH), 5.41 (s, 2H), 3.96 (s, 3H). LC-MS Rt = 1.34 min, m/z 391.1 (MH+)
35 (5£)-4-amino-6-[2,2-difluoro-2-(6-methyl-pyridin-2-yl)-ethylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (CD3OD) δ 8.41 (s, IH), 7.85 (s, IH), 7.79 (t, J = 7.81 Hz, IH), 7.49 (t, J = 7.79 Hz, IH), 7.35 (d, J = 7.74 Hz, IH), 4.44 (t, J = 13.98 Hz, 2H), 3.81 (s, 3H), 2.56 (s, 3H). LC-MS Rt = 0.59 min (32.36%), m/z 323.2 (MH+); Rt = 0.88 min (67.64%), m/z 323.2 (MH+)
36 (5£)-4-amino-6-(3-bromo-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime
1H NMR (CDCl3) δ 8.31 (br, IH), 8.17 (s, IH), 7.78 (m, IH), 7.34-7.44 (3H), 4.07 (s, 3H). LC-MS Rt = 1.07 min, m/z 322.0 (MH+).
37 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-ethyl-oxime
1H NMR (CDCl3) δ 9.59 (br, IH), 8.30 (s, 1 H), 8.16 (s, IH), 7.65 (d, J = 2.64 Hz, IH), 7.30-7.48 (6H), 6.95 (d, J = 8.87 Hz, IH), 5.73 (br, 2H), 5.16 (s, 2H), 4.27 (q, J = 7.05 Hz, 2 H), 1.37 (t, J = 7.06 Hz, 3H). LC-MS Rt = 1.49 min, m/z 398.1 (MH+)
38 (5£)-4-amino-6-[3-chloro-4-(pyridin-3-yloxy)-phenylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (CDCl3) δ 10.14 (br, IH), 8.41 (s, IH), 8.38 (m, 2H), 8.19 (s, IH), 7.81 (d, J = 2.79 Hz, IH), 7.42 (dd, J = 8.97 and 2.63 Hz, IH), 7.29 (m, 2H), 7.07 (d, J = 8.84 Hz, IH), 6.68 (br, 2H), 4.06 (s, 3H). LC-MS Rt = 0.55 min, m/z 371.0 (MH+)
44 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(4-methoxy-benzyl)-oxime
1H NMR (CD3OD) δ 8.60 (s, IH), 8.05 (d, J = 0.96 Hz, IH), 7.89 (s, IH), 7.76 (m, IH), 7.47 (d, J = 8.93 Hz, IH), 7.22-7.36 (4H), 6.94-7.03 (3H), 6.85 (m, 2H), 5.66 (s, 2H), 5.11 (s, 2H), 3.68 (s, 3H). LC-MS Rt = 1.41 min, m/z 498.1 (MH+)
45 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-methoxy-benzyl)-oxime
1H NMR (CD3OD) δ 8.60 (s, IH), 8.05 (d, J = 0.92 Hz, IH), 7.89 (s, IH), 7.80 (dd, J = 1.94 and 0.73 Hz, IH), 7.49 (d, J = 8.97 Hz, IH), 7.37 (dd, J = 7.43 and 2.09 Hz, IH), 7.29 (m, 3H), 6.94-7.03 (3H), 6.88 (m, 2H), 5.66 (s, 2H), 5.22 (s, 2H), 3.77 (s, 3H). LC-MS Rt = 1.46 min, m/z 498.0 (MH+) Cpd Name and Data
46 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-benzyl-oxime
1H NMR (CD3OD) δ 8.64 (s, IH), 8.04 (d, J = 0.88 Hz, IH), 7.90 (s, IH), 7.77 (m, IH), 7.41-7.47 (3H), 7.27-7.36 (4H), 7.22 (dd, J = 8.96 and 1.96 Hz, IH), 6.95-7.02 (2H), 6.87 (dt, J = 9.58 and 2.01 Hz, IH), 5.65 (s, 2H), 5.19 (s, 2H). LC-MS Rt = 1.42 min, m/z 468.1 (MH+).
47 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-isopropyl-oxime
1H NMR (CD3OD) δ 8.57 (s, IH), 8.05 (d, J = 0.88 Hz, IH), 7.94 (dd, J = 1.92 and 0.82 Hz, IH), 7.92 (s, IH), 7.51 (d, J = 8.92 Hz, IH), 7.42 (dd, J = 8.99 and 1.95 Hz, IH), 7.30 (td, J = 7.98 and 5.73 Hz, IH), 6.94-7.02 (2H), 6.87 (dt, J = 9.66 and 2.01 Hz, IH), 5.65 (s, 2H), 4.46 (m, IH), 1.32 (d, J = 6.24 Hz, 6H). LC-MS Rt = 1.34 min, m/z 420.2 (MH+)
48 (5£)-4-amino-6-(l -benzyl- lH-indazol-5-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime
1H NMR (CD3OD) δ 8.60 (s, IH), 8.03 (d, J = 0.91 Hz, IH), 7.92 (d, J = 0.77 Hz, IH), 7.91 (s, IH), 7.50 (dt, J = 8.96 and 0.74 Hz, IH), 7.40 (dd, J = 8.93 and 1.91 Hz, IH), 7.16-7.32 (5H), 5.64 (s, 2H), 3.98 (s, 3H). LC-MS Rt = 1.12 min, m/z 374.1 (MH+)
49 (5£)-4-amino-6-(l -benzyl- lH-indazol-5-ylamino)-pyrimidine-5-carbaldehyde O- ethyl-oxime
1H NMR (CD3OD) δ 8.59 (s, IH), 8.03 (d, J = 0.89 Hz, IH), 7.93 (dd, J = 1.90 and 0.73 Hz, IH), 7.91 (s, IH), 7.51 (dt, J = 9.01 and 0.78 Hz, IH), 7.40 (dd, J = 8.94 and 1.94 Hz, IH), 7.16-7.32 (5H), 5.64 (s, 2H), 4.23 (q, J = 7.07 Hz, 2H), 1.34 (t, J = 7.04 Hz, 3H). LC-MS Rt = 1.21 min, m/z 388.1 (MH+)
50 3-{5-[6-amino-(5£)-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-indazol-l- ylmethyl} -benzonitrile
1H NMR (CD3OD) δ 8.60 (s, IH), 8.07 (d, J = 0.91 Hz, IH), 7.93 (dd, J = 1.92 and 0.71 Hz, IH), 7.92 (s, IH), 7.63 (td, J = 5.39 and 1.81 Hz, IH), 7.54 (dt, J = 8.90 and 0.86 Hz, IH), 7.53 (s, IH), 7.48 (m, 2H), 7.44 (dd, J = 8.95 and 1.94 Hz, IH), 5.71 (s, 2H), 3.98 (s, 3H). LC-MS Rt = 1.08 min, m/z 399.2 (MH+)
51 3-{5-[6-amino-(5£)-5-(ethoxyimino-methyl)-pyrimidin-4-ylamino]-indazol-l- ylmethyl} -benzonitrile
1H NMR (CD3OD) δ 8.60 (s, IH), 8.07 (d, J = 0.91 Hz, IH), 7.94 (dd, J = 1.92 and 0.73 Hz, IH), 7.92 (s, IH), 7.62 (td, J = 5.25 and 1.61 Hz, IH), 7.54 (dt, J = 8.97 and 0.86 Hz, IH), 7.53 (m, IH), 7.48 (m, 2H), 7.43 (dd, J = 8.95 and 1.96 Hz, IH), 5.70 (s, 2H), 4.24 (q, J = 7.07 Hz, 2H), 1.34 (t, J = 7.08 Hz, 3H). LC-MS Rt = 1.16 min, m/z 413.3 (MH+)
52 (5£)-4-amino-6-(2-benzyl-2H-indazol-5-ylamino)-pyrimidine-5-carbaldehyde O- ethyl-oxime
1H NMR (CD3OD) δ 8.59 (s, IH), 8.22 (d, J = 0.73 Hz, IH), 7.95 (s, IH), 7.93 (dd, J = 1.98 and 0.76 Hz, IH), 7.58 (dt, J = 9.21 and 0.85 Hz, IH), 7.27-7.37 (6H), 5.62 (s, 2H), 4.24 (q, J = 7.10 Hz, 2H), 1.35 (t, J = 7.05 Hz, 3H). LC-MS Rt = 1.16 min, m/z 388.2 (MH+) Cpd Name and Data
54 (5£)-4-amino-6-[l-(3-chloro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (SOO Hz, CDCl3) δ 9.88 (bs, IH), 8.44 (bs, IH), 8.13 (s, IH), 8.06 (s, IH), 7.93 (s, IH), 7.39-7.05 (m, 6H), 6.37 (bs, IH), 5.57 (s, 2H), 4.02 (s, 3H); ); LC/MS (m/z) (MH+) 408.1 (calculated for C20H18ClN7O, 407.86)
55 (5£)-4-amino-6-[l-(3-chloro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime
1H NMR (300 Hz, CDCl3) δ 9.63 (bs, IH), 8.36 (s, IH), 8.16 (s, IH), 8.04 (s, IH), 7.96 (m, IH), 7.43-7.04 (m, 6H), 5.68 (bs, IH), 5.30 (s, 2H), 4.26 (q, J = 7.05 Hz, 2H), 1.37 (t, J = 7.05 Hz, 3H); LC/MS (m/z) (MH+) 422.1 (calculated for C2IH20ClN7O, 421.88)
56 (5£)-4-amino-6-[l-(3-methoxy -benzyl)- lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (300 Hz, CDCl3) δ 9.89 (bs, IH), 8.43 (s, IH), 8.12 (s, IH), 8.04 (s, IH), 7.91 (bs, IH), 7.36-7.19 (m, 2H), 6.82-6.6.44 (m, 2H), 5.57 (s, 2H), 4.02 (s, 3H), 3.74 (s, 3H); LC/MS (m/z) (MH+) 404.2 (calculated for C21H21N7O2, 403.44)
57 (5£)-4-amino-6-[l-(3-methoxy -benzyl)- lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime
1H NMR (300 Hz, CDCl3) δ 10.45 (bs, IH), 8.40 (s, IH), 8.069 (s, IH), 8.067 (s, IH), 7.85 (s, IH), 7.55 (bs, IH), 7.36-7.27 (m, 3H), 6.74 (m, 3H), 5.58 (s, 2H), 4.28 (q, J = 7.08 Hz, 2H), 3.75 (s, 3H), 1.37 (t, J = 7.08 Hz, 3H); LC/MS (m/z) (MH+) 418.2 (calculated for C22H23N7O2, 417.46)
58 (5£)-4-amino-6-[2-(3-fluoro-benzyl)-lH-benzoimidazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime
1H NMR (CD3OD) δ 8.64 (s, IH), 8.13 (s, IH), 8.11 (d, J = 1.83 Hz, IH), 7.68 (d, J = 8.77 Hz, IH), 7.49 (dd, J = 8.82 and 1.86 Hz, IH), 7.43 (m, IH), 7.07-7.24 (3H), 4.52 (s, 2H), 4.30 (q, J = 7.10 Hz, 2H), 1.36 (t, J = 7.07 Hz, 3H). LC-MS Rt = 0.28 min (68.74%), m/z 406.0 (MH+); Rt = 0.76 min (31.26%), m/z 406.2 (MH+)
59 (5£)-4-amino-6-(3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime
1H NMR (CDCl3) δ 9.82 (br, IH), 8.28 (s, IH), 8.21 (s, IH), 7.41 (m, IH), 7.30 (m, IH), 7.13 (m, IH), 5.96 (br, 2H), 4.05 (s, 3H). LC-MS Rt = 0.56 min (51.88%), m/z 278.0 (MH+); Rt = 1.02 min (48.12%), m/z 278.1 (MH+)
60 (5£)-4-amino-6-[2-(3-fluoro-benzyl)-lH-benzoimidazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (CD3OD) δ 8.59 (s, IH), 7.94 (s, IH), 7.83 (dd, J = 1.99 and 0.54 Hz, IH), 7.50 (dd, J = 8.59 and 0.53 Hz, IH), 7.34 (dt, J = 6.09 and 7.96 Hz, IH), 7.23 (dd, J = 8.60 and 2.01 Hz, IH), 7.14 (dt, J = 7.60 and 0.75 Hz, IH), 7.06 (dt, J = 9.98 and 1.94 Hz, IH), 6.99 (td, J = 8.84 and 2.87 Hz, IH), 4.27 (s, 2H), 3.99 (s, 3H). LC-MS Rt = 0.55 min, m/z 392.1 (MH+)
61 (5£)-4-amino-6-[4-(3-fluoro-benzyloxy)-3-methoxy-phenylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (300 Hz, CDCl3) δ 9.32 (bs, IH), 8.32 (s, IH), 8.16 (s, IH), 7.36-7.02 (m, 4H), 6.91-6.82 (m, 3H), 5.62 (bs, IH), 5.13 (s, 2H), 3.998 (s, 3H), 3.91 (s, 3H); LC/MS (m/z) (MH+) 398.1 (calculated for C20H20FN5O3, 397.40) Cpd Name and Data
62 (5£)-4-amino-6-[4-(3-fluoro-benzyloxy)-3-methoxy-phenylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime
1H NMR (SOO Hz, CDCl3) δ 9.51 (bs, IH), 8.32 (s, IH), 8.15 (s, IH), 7.36-7.16 (m. 4H), 7.02-6.82 (m, 3H), 5.80 (bs, IH), 5.13 (s, 2H), 4.25 (q, J = 7.06 Hz, 2H), 3.91 (s, 3H), 1.36 (t, J = 7.06 Hz, 3H); ); LC/MS (m/z) (MH+) 412.2 (calculated for C2IH22FN5O3, 411.43)
63 (5£)-4-amino-6-(3-chloro-4-methoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime
1H NMR (CDCl3) δ 9.32 (br, IH), 8.28 (s, IH), 8.18 (s, IH), 7.61 (d, J = 2.63 Hz, IH), 7.39 (dd, J = 8.85 and 2.63 Hz, IH), 6.93 (d, J = 8.86 Hz, IH), 5.39 (br, 2H), 4.02 (s, 3H), 3.90 (s, 3H). LC-MS Rt = 1.00 min, m/z 308.1 (MH+)
64 (5£)-4-amino-6-(3-chloro-4-morpholin-4-yl-phenylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (CDCl3) δ 9.43 (br, IH), 8.28 (s, IH), 8.19 (s, IH), 7.66 (d, J = 2.51 Hz, IH), 7.41 (dd, J = 8.71 and 2.66 Hz, IH), 7.04 (d, J = 8.68 Hz, IH), 5.45 (br, 2H), 4.02 (s, 3H), 3.88 (t, J = 4.59 Hz, 4H), 3.04 (t, J = 4.55 Hz, 4H). LC-MS Rt = 1.02 min, m/z 363.1 (MH+)
65 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-phenyl-oxime
1H NMR (CDCl3) δ 8.70 (s, IH), 8.21 (s, IH), 8.04 (s, IH), 7.99 (s, IH), 6.81-7.44 (10H), 5.58 (s, 2H). LC-MS Rt = 1.44 min, m/z 454.2 (MH+)
66 (5£)-4-amino-6-[l-(4-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (300 Hz, CDCl3) δ 9.64 (bs, IH), 8.38 (s, IH), 8.14 (s, IH), 8.02 (s, IH), 7.93 (s, IH), 7.42-7.16 (m, 4H), 7.01-6.95 (m, 2H), 5.92 (bs, 2H), 5.56 (s, 2H), 4.01 (s, 3H); LC/MS (m/z) (MH+) 392.2 (calculated for C20H18FN7O, 391.40)
67 (5£)-4-amino-6-[l-(4-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime
1H NMR (300 Hz, CDCl3) δ 9.73 (bs, IH), 8.37 (s, IH), 8.15 (s, IH), 8.02 (s, IH), 7.93 (s, IH), 7.41-7.16 (m, 4H), 7.01-6.95 (m, 2H), 5.94 (bs, IH), 5.56 (s, 2H), 4.25 (q, J = 7.06 Hz, 2H), 1.36 (t, J = 7.06 Hz, 3H); LC/MS (m/z) (MH+) 406.2 (calculated for C2iH20FN7O, 405.43)
68 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-methoxy-ethyl)-oxime
1H NMR (CD3OD) δ 8.60 (s. IH), 8.05 (d, J = 0.89 Hz, IH), 7.93 (dd, J = 1.91 and 0.75 Hz, IH), 7.92 (s, IH), 7.51 (dt, J = 8.97 and 0.76 Hz, IH), 7.43 (dd, J = 8.94 and 1.93 Hz, IH), 7.30 (td, J = 7.97 and 5.95 Hz, IH), 7.01 (m, IH), 6.96 (m, IH), 6.87 (dt, J = 9.70 and 1.71 Hz, IH), 5.65 (s, IH), 4.32 (t, J = 4.49 Hz, 2H), 3.71 (t, J = 4.60 Hz, 2H), 3.35 (s, 3H). LC-MS Rt = 1.13 min, m/z 436.2 (MH+)
69 (52)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3-hydroxy-propyl)-oxime
1H NMR (CD3OD) δ 8.62 (s, IH), 8.05 (d, J = 0.89 Hz, IH), 7.93 (dd, J = 1.91 and 0.75 Hz, IH), 7.91 (s, IH), 7.46 (m, 2H), 7.30 (m, IH), 7.01 (m, IH), 6.87-6.96 (2H), 5.65 (s, 2H), 4.28 (t, J = 6.48 Hz, 2H), 3.69 (t, J = 6.35 Hz, 2H), 1.94 (m, 2H). LC-MS Rt = 0.55 min, m/z 436.3 (MH+) Cpd Name and Data
70 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3-dimethylamino-propyl)-oxime
1H NMR (CDCl3) δ 9.38 (br, IH), 8.33 (s, IH), 8.18 (s, IH), 8.03 (d, J = 0.73 Hz, IH), 7.97 (d, J = 1.92 Hz, IH), 7.42 (dd, J = 8.87 and 1.91 Hz, IH), 7.23-7.37 (2H), 6.91-6.98 (2H), 6.86 (m, IH), 5.58 (s, 2H), 5.21 (br, 2H), 4.26 (t, J = 6.51 Hz, 2H),
2.41 (t, J = 7.05 Hz, 2H), 2.24 (s, 6H), 1.92 (m, 2H). LC-MS Rt = 0.29 min (37.41%), m/z 463.2 (MH+); Rt = 0.76 min (62.59%), m/z 463.2 (MH+)
71 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-(2-methoxy-ethyl)-oxime
1H NMR (CD3OD) δ 8.56 (s, IH), 7.95 (s, IH), 7.66 (d, J = 2.58 Hz, IH), 7.47 (m, 2H), 7.28-7.40 (4H), 7.08 (d, J = 8.89 Hz, IH), 5.16 (s, 2H), 4.32 (t, J = 4.45 Hz, 2H), 3.71 (t, J = 4.58 Hz, 2H), 3.36 (s, 3H). LC-MS Rt = 1.36 min, m/z 428.1 (MH+)
72 (5£)-4-amino-6-[2-(3-fluoro-phenyl)-benzoruran-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (300 Hz, CDCl3) δ 9.80 (bs, IH), 8.44 (s, IH), 8.15 (s, IH), 7.82 (d, J = 2.16 Hz, IH), 7.64-7.26 (m, 5H), 7.09-7.03 (m, 2H), 6.24 (bs, IH), 4.03 (s, 3H); LC/MS (m/z) (MH+) 378.2 (calculated for C20H16FN5O2, 377.37)
73 (5£)-4-amino-6-(2-benzyl-benzofuran-5-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime
1H NMR (300 Hz, CDCl3) δ 9.35 (bs, IH), 8.33 (s, IH), 8.14 (s, IH), 7.69 (d, J = 2.12 Hz, IH), 7.38-7.21 (m, 8H), 5.55 (bs, IH), 4.10 (s, 2H), 3.99 (s, 3H); LC/MS (m/z) (MH+) 374.1 (calculated for C2iH19N5O2, 373.41)
74 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-2,3-dihydro-lH-indol-5-ylamino]-pyrimidine- 5-carbaldehyde O-methyl-oxime
1H NMR (CDCl3) δ 9.07 (s, IH), 8.29 (s, IH), 8.13 (s, IH), 7.29 (td, J = 7.55 and 5.49 Hz, IH), 7.24 (m, IH), 7.14 (d, J = 8.01 Hz, IH), 7.09 (dd, J = 9.89 and 2.23 Hz, IH), 7.04 (dd, J = 8.71 and 2.05 Hz, IH), 6.96 (td, J = 8.11 and 2.65 Hz, IH),
6.42 (d, J = 8.31 Hz, IH), 5.42 (br, 2H), 4.23 (s, 2H), 3.98 (s, 3H), 3.36 (t, J = 8.19 Hz, 2H), 3.01 (t, J = 8.29 Hz, 2H); LC-MS Rt = 1.48 min, m/z 393.3 (MH+)
75 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-pyrimidine-5- carbaldehyde O-(3-hydroxy-propyl)-oxime
1H NMR (300 Hz, CDCl3) δ 8.56 (s, IH), 7.96 (s, IH), 7.70 (d, J= 2.55 Hz, IH), 7.01-7.00 (m, 6H), 5.17 (s, 2H), 4.29 (t, J= 6.35 Hz, 2H), 3.70 (d, J= 6.35 Hz, 2H), 1.96 (m, 2H); LC/MS (m/z) 446.2 (MH+) (calculated for C2iH21ClFN5O3, 445.87).
76 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-(3-hydroxy-propyl)-oxime
1H NMR (400 MHz, CD3OD) δ 8.56 (s, IH), 7.97 (s, IH), 7.67 (d, j=2.5, IH), 7.46 (d, j=7.1, 2H), 7.38-7.25(m,4H), 7.06 (d, j=8.9, IH), 5.15 (s,2H), 4.28 (t, j=12.5, 2H), 3.70 (t,j=12.7, 2H), 1.97-1.94 (m,2H); MS (ESI) m/z 427, 428 (MH+), 426 (MH-) Cpd Name and Data
77 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde oxime
1H NMR (300 MHz, CD3OD) δ 8.52 (s, IH), 7.96 (s, IH), 7.66 (d, J = 2.4 Hz, IH), 7.50-7.29 (m , 6H), 7.10 (d, J = 9 Hz, IH), 5.17 (s, 2H); MS (ESI) m/z 370 (MH+)
79 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-pyrimidine-5- carbaldehyde oxime
1H NMR (300 MHz, CD3OD) δ 8.51 (s, IH), 7.95 (s, IH), 7.66 (d, J = 2.4 Hz, IH), 7.40-7.04 (m, 7H), 5.17 (s, 2H)
80 (5£)-4-amino-6-(4-chloro-2-fluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 296.1 (MH+)
81 (52)-4-amino-6-(4-chloro-2-fluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 296.1 (MH+)
82 (5£)-4-amino-6-(4-bromo-2-fluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 340 (MH+)
83 (52)-4-amino-6-(4-bromo-2-fluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 340 (MH+)
84 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde oxime
1H NMR (300 MHz, OMSO-d6) δ 11.22 (s, IH), 9.92 (s, IH), 8.65 (s, IH), 8.09 (s, IH), 8.04 (d, J = 1.8 Hz, IH), 7.97 (s, IH), 7.65 (d, J = 9.0 Hz, IH), 7.44-7.36 (m, 2H), 7.11-7.03 (m, 5H), 5.66 (s, 2H); MS (ESI) m/z 376 (MH+)
85 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3-hydroxy-propyl)-oxime
1H NMR (300 MHz, CDCl3) δ 9.40 (s, IH), 8.34 (s, IH), 8.18 (s, IH), 8.04 (s, IH), 7.94 (s, IH), 7.40-7.25 (m, 2H), 6.98-6.84 (m, 3H), 5.58 (s, 2H), 5.33 (br s, 2H), 4.37 (t, J = 5.7 Hz, 2H), 3.83 (t, J = 12.3 Hz, 2H), 2.04 (m, 2H); MS (ESI) m/z 434 (MH+)
86 (5£)-4-(4-bromo-2-fluoro-phenylamino)-6-methoxyamino-pyrimidine-5- carbaldehyde O-methyl-oxime MS m/z 370 (MH+)
87 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3-morpholin-4-yl-propyl)-oxime
1H NMR (300 MHz, CDCl3) δ 9.37 (s, IH), 8.34 (s, IH), 8.17 (s, IH), 8.03 (s, IH), 7.96 (s, IH), 7.42 (dd, J = 9.0, 1.8 Hz, IH), 7.30-7.24 (m, #H), 6.97-6.83 (m, 3H), 5.57 (s, 2H), 5.34 (s, 2H), 4.26 (t, J = 6.3 Hz, 2H), 3.72 (m, 4H), 2.52 (m, 6H), 1.95 (m, 2H); MS (ESI) m/z 505 (MH+)
88 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde oxime
1H NMR (SOO MHz, OMSO-d6) δ 11.18 (s, IH), 9.89 (s, IH), 8.65 (s, IH), 7.95 (s, IH), 7.81 (d, J = 1.5 Hz, IH), 7.52 (d, J = 3.0 Hz, IH), 7.42-7.02 (m, 7H), 6.48 (d, J = 2.7 Hz, IH), 5.44 (s, 2H); MS (ESI) m/z 377 (MH+)
89 (5£)-4-amino-6-(4-chloro-2-fluoro-5-hydroxy-phenylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime MS m/z 312.1 (MH+)
90 (52)-4-amino-6-(4-chloro-2-fluoro-5-hydroxy-phenylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime MS m/z 312.1 (MH+) Cpd Name and Data
91 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3-hydroxy-propyl)-oxime
1H NMR (300 MHz, OMSO-d6) δ 9.74 (s, IH), 8.74 (s, IH), 7.98 (s, IH), 7.86 (d, J = 1.8 Hz, IH), 7.53 (d, J = 3.3 Hz, IH), 7.38-7.34 (m, 2H), 7.20-7.00 (m, 6H), 6.49 (d, J = 3.0 Hz, IH), 5.78 (s, 2H), 4.56 (t, J = 5.1 Hz, IH), 4.24 (t, J = 6.3 Hz, 2H), 3.55 (m, 2H), 1.86 (m, 2H); MS (ESI) m/z 435 (MH+)
92 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3-piperidin- 1 -yl-propyl)-oxime
1H NMR (300 MHz, CD3OD) δ 8.62 (s, IH), 8.05 (s, IH), 7.92 (s, IH), 7.52 (m, 2H), 7.40 (m, IH), 7.02-6.85 (m, 3H), 5.65 (s, 2H), 4.23 (t, J = 6.3 Hz, 2H), 2.60 (m ,6H), 2.00 (m, 2H), 1.61 (m, 4H), 1.47 (m, 2H); MS (ESI) m/z 503 (MH+)
93 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime
1H NMR (300 MHz, CD3OD) δ 8.59 (s, IH), 7.98 (s, IH), 7.68 (d, J = 2.7 Hz, IH), 7.42-7.26 (m, 4H), 7.10-7.06 (m, 2H), 5.20 (s, 2H), 4.38 (t, J = 5.7 Hz, 2H), 3.71 (t, J = 4.8 Hz, 4H), 2.78 (t, J = 5.7 Hz, 2H), 2.59 (t, J = 4.5 Hz, 4H); MS (ESI) m/z 499 (MH+)
94 (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-pyrimidine-5- carbaldehyde O-(2-piperidin- 1 -yl-ethyl)-oxime
1H NMR (300 MHz, OMSO-d6) δ 9.63 (s, IH), 8.72 (s, 2H), 8.03 (s, IH), 7.85 (d, J = 3.0 Hz, IH), 7.49-7.17 (m, 7H), 5.23 (s, 3H), 4.27 (t, J = 6.0 Hz, 2H), 2.61 (t, J = 5.4 Hz, 2H), 2.50 (m, 4H), 1.51-1.37 (m, 6H); MS (ESI) m/z 499 (MH+)
95 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-(2-piperidin- 1 -yl-ethyl)-oxime
1H NMR (300 MHz, OMSO-d6) δ 9.63 (s, IH), 8.72 (s, IH), 8.03 (s, IH), 7.85 (d, J = 3.0 Hz, IH), 7.50-7.18 (m, 9H), 5.21 (s, 2H), 4.28 (t, J = 6.0 Hz, 2H), 2.61 (t, J = 6.0 Hz, 2H), 2.39 (m, 4H), 1.49 (m, 4H), 1.39 (m, 2H); MS (ESI) m/z 481 (MH+)
96 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-piperidin- 1 -yl-ethyl)-oxime
1H NMR (400 MHz, OMSO-d6) δ 9.78 (s, IH), 8.74 (s, IH), 8.08 (d, j=302, 2H), 7.99 (s, IH), 7.64 (d,j=9.0, IH), 7.44-7.32 (m, 2H), 7.19(s, 2H), 7.11-7.01 (m, 3H), 5.67 (s, 2H), 4.27 (t, j=l 1.6, 2H), 2.61 (t, j=11.5, 2H), 2.49-2.39 (m, 4H), 1.50-1.45 (m, 4H), 1.35 (d, j=5.0,2H)
97 (5£)-4-amino-6-[3-chloro-4-(3,5-difluoro-benzyloxy)-phenylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (300 MHz, OMSO-d6) δ 9.60 (s, IH), 8.71 (s, IH), 8.04 (s, IH), 7.88 (d, J = 2.7 Hz, IH), 7.42 (dd, J = 9.3, 2.7 Hz, IH), 7.30-7.16 (m, 6H), 5.25 (s, 2H), 3.98 (s, 3H); MS (ESI) m/z 420 (MH+)
98 (5£)-4-amino-6-[3-chloro-4-(3,5-difluoro-benzyloxy)-phenylamino]-pyrimidine-5- carbaldehyde oxime
1H NMR (SOO MHz, OMSO-d6) δ 11.25 (s, IH), 9.81 (s, IH), 8.62 (s, IH), 8.01 (s, IH), 7.82 (d, J = 2.4 Hz, IH), 7.42 (dd, J = 9.0, 2.7 Hz, IH), 7.23-7.17 (m, 6H), 5.23 (s, 2H); MS (ESI) m/z 406 (MH+) Cpd Name and Data
99 (5£)-4-amino-6-[3-chloro-4-(3,5-difluoro-benzyloxy)-phenylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime
1H NMR (300 MHz, OMSO-d6) δ 9.61 (s, IH), 8.73 (s, IH), 8.04 (s, IH), 7.87 (d, J = 2.7 Hz, IH), 7.42 (dd, J = 8.7, 2.7 Hz, IH), 7.29-7.16 (m, 6H), 5.24 (s, 2H), 4.30 (t, J = 5.7 Hz, 2H), 3.58 (m, 4H), 2.66 (t, J = 5.7 Hz, 2H), 2.45 (m, 4H); MS (ESI) m/z 519 (MH+)
100 (5£)-4-amino-6-[(l S)- 1 -phenyl-ethylamino]-pyrimidine-5-carbaldehyde oxime MS m/z 258.1 (MH+)
101 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime
1H NMR (400 MHz, OMSO-d6) δ 9.72 (s, IH), 8.73 (s, IH), 7.95 (s, IH), 7.83 (d, j=1.7, IH), 7.50 (d, j=3.0, IH), 7.38-7.32 (m,2H), 7.18-6.97 (m,6H), 6.46 (d, j=2.9, IH), 5.43 (s, 2H), 4.27 t, j=l 1.3, 2H), 3.55 (t, j=9.0, 4H), 2.65 (t, j=l 1.3, 2H), 2.50- 2.44 (m,4H); MS (ESI) m/z 490 (MH+), 488 (MH-)
102 (5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde 0-(2-piperidin- 1 -yl-ethyl)-oxime
1H NMR (400 MHz, CD3OD) δ 8.61-8.59 (m, IH), 7.86-7.83 (m, IH), 7.64-7.62 (m, IH), 7.32-7.25 (m, 3H), 7.12-7.08 (m, IH), 6.96-6.94 (m,2H), 6.77 (d, j=9.3, IH), 6.51-6.48 (m,lH), 5.41-5.38 (m,2H), 4.35-4.31 m, 2H), 2.77-2.74 (m, 2H), 2.53 (s, IH), 1.59 (s, 4H), 1.45 (s, 2H); MS (ESI) m/z 488 (MH+), 486 (MH-)
103 (5£)-4-amino-6-[(l S)- 1 -phenyl-ethylamino]-pyrimidine-5-carbaldehyde O-(2- morpholin-4-yl-ethyl)-oxime MS m/z 371.2 (MH+)
104 N- {4-[6-amino-(5£)-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-phenyl} - benzamide MS m/z 363.2 (MH+)
105 N- {4-[6-amino-(5£)-5-(hydroxyimino-methyl)-pyrimidin-4-ylamino]-phenyl} - benzamide MS m/z 349.1 (MH+)
106 (5£)-4-amino-6-[(l S)- 1 -phenyl-ethylamino]-pyrimidine-5-carbaldehyde O-(2- piperidin-l-yl-ethyl)-oxime MS m/z 369.2 (MH+)
107 N-(4-{6-amino-(5£)-5-[(2-morpholin-4-yl-ethoxyimino)-methyl]-pyrimidin-4- ylamino}-phenyl)-benzamide MS m/z 462.2 (MH+)
108 (5£)-4-amino-6-(3-chloro-4-fluoro-phenylamino)-pyrimidine-5-carbaldehyde O-(2- morpholin-4-yl-ethyl)-oxime
1H NMR (400 MHz, CD3OD) δ 8.58 (d, j=2.6, IH), 8.00 (d, j=2.2, IH), 7.82-7.80 (m,lH), 7.40-7.36 (m,lH), 7.20-7.16 (m, IH), 4.37 (t, j=12.1, 2H), 3.71-3.69 (m,4H), 2.77 (t, j=l l.l, 2H), 2.58 (d, j=4.8, 4H); MS (ESI) m/z 394, 395 (MH+) 396
109 (5£)-4-amino-6-(4-phenoxy-phenylamino)-pyrimidine-5-carbaldehyde O-(2- morpholin-4-yl-ethyl)-oxime
1H NMR (400 MHz, OMSO-d6) δ 8.12 (s, IH), 7.42-7.34 (m,4H), 7.13-7.05 (m,6H), 4.02 (t, j=13.3, 2H), 3.50 (d, j=4.0, 4H), 2.52-2.50 (m, 2H), 2.33 (s, 4H)
110 N- {5-[6-amino-(5£)-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-pyrimidin-2- yl} -benzamide MS m/z 365.1 (MH+)
111 (5£)-4-amino-6-(4-phenoxy-phenylamino)-pyrimidine-5-carbaldehyde oxime MS m/z 322.1 (MH+) Cpd Name and Data
112 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-(3-morpholin-4-yl-propyl)-oxime
1H NMR (400 MHz, CD3OD) δ 8.56 (s, IH), 7.95 (s, IH), 7.66 (d, j=2.5, IH), 7.46 (d, j=7.1, 2H), 7.38-7.26 (m,4H), 7.06 (d, j=28.9, IH), 5.15 (s, IH), 4.23 (t, j=12.5, 2H), 3.67 (t, j=9.6, 4H), 2.53-2.46 (m, 6H), 2.00-1.90 (m, 2H); MS (ESI) m/z 497 (MH+)
113 methanesulfonic acid (5£)-3-[4-amino-6-(4-benzyloxy-3-chloro-phenylamino)- pyrimidin-5-ylmethyleneaminooxy]-propyl ester
1H NMR (400 MHz, CD3OD) δ 8.58 (s, IH), 7.95 (s, IH), 7.67 (d, j=2.4, IH), 7.47- 7.45 (m, 2H), 7.38-7.23 (m,4H), 7.07-7.04 (m, IH), 5.14 (s, 2H), 4.38 (t, j=12.4, 2H), 4.30 (t, j=12.2, 2H), 3.07 (s, 3H), 2.18-2.15 (m, 2H)
114 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-pyridin-2-ylmethyl-oxime
1H NMR (400 MHz, CD3OD) δ 8.66 (s, IH), 8.52-8.49 (m, IH), 7.92 (s, IH), 7.85- 7.80 (m, IH), 7.58-7.55 (m, IH), 7.49-7.42 (m, 3H), 7.40-7.28 (m,4H), 7.16-7.12 (m,lH), 7.05-7.01 (m,lH), 5.28 (s, 2H), 5.16 (s, 2H)
115 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O- [3 -(2-methoxy-ethylamino)-propyl] -oxime
1H NMR (400 MHz, CD3OD) δ 8.56 (s, IH), 7.95 (s, IH), 7.66 (d, j=2.4, IH), 7.46 (d, j=7.6, 2H), 7.38-7.24 (m, 4H), 7.05 (d, j=8.9, IH), 5.14 (s, 2H), 4.25 (t, j=12.3, 2H), 3.49-3.47 (m,2H), 3.31-3.29 (m,3H), 2.80-2.76 (m, 4H), 1.99-1.92 (m,2H); MS (ESI) m/z 512, 485 (MH+), 483 (MH-)
116 (5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde O- [3 -(4-hydroxy-piperidin- 1 -yl)-propyl] -oxime
1H NMR (400 MHz, CD3OD) δ 8.55 (s, IH), 7.95 (s, IH), 7.66 (d, j=2.4, IH), 7.47- 7.25 (m,6H), 7.05 (d, j=8.9, IH), 5.14 (s, 2H), 4.21 (t, j=12.0, 2H), 3.62 (s, IH), 2.84-2.81 (m,2H), 2.54-2.50 (m,2H), 2.22-2.18 (m,2H), 1.98-1.91 (m,2H), 1.87- 1.83 (m, 2H), 1.60-1.51 (m,2H); MS (ESI) m/z 511, 512 (MH+), 513, 509, 510 (MH-)
117 (5£)-4-[4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidin-5- ylmethyleneaminooxymethyl]-piperidine-l-carboxylic acid tert-butyl ester
1H NMR (400 MHz, CD3OD) δ 8.57 (s, IH), 7.95 (s, IH), 7.65 (d, j=2.6, IH), 7.48- 7.45 (m,2H), 7.39-7.35 (m,2H), 7.34-7.23 (m, 2H), 7.09-7.05 (m, IH), 5.15 (s, 2H), 4.06 (d, j=6.4, 4H), 2.82-2.75 (m,2H), 1.81-1.74 (m, 2H), 1.44 (s,9H), 1.30- 1.17 (m, 2H); MS (ESI) m/z 567 (MH+), 565 (MH-)
119 N-benzo[l,3]dioxol-5-ylmethyl-5-[(benzo[l,3]dioxol-5-ylmethylimino)- methyl]-pyrimidine-4,6-diamine MS m/z 406 (MH+)
120 4-amino-6-(4-methoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 274 (MH+)
121 4-amino-6-[(benzo[l,3]dioxol-5-ylmethyl)-amino]-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 302 (MH+)
122 4-amino-6-(3,4-dimethoxy-benzylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 318 (MH+) Cpd Name and Data
123 4-amino-6-(4-phenoxy-benzylamino)-pyrimidine-5-carbaldehyde 0-methyl-oxime MS m/z 350 (MH+)
124 4-amino-6-(indan- 1 -ylamino)-pyrimidine-5-carbaldehyde 0-methyl-oxime MS m/z 284(MH+)
125 4-amino-6-(l ,2,3,4-tetrahydro-naphthalen- 1 -ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 298 (MH+)
126 4-amino-6-[l-(4-chloro-phenyl)-ethylamino]-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 306 (MH+)
127 4-amino-6-[l-(4-methoxy-phenyl)-ethylamino]-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 302 (MH+)
128 4-amino-6-(6-phenoxy-pyridin-3-ylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 337 (MH+)
129 4-amino-6-(6-morpholin-4-yl-pyridin-3-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 330 (MH+)
130 4-amino-6-(l,4-dioxo-l,2,3,4-tetrahydro-phthalazin-5-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime MS m/z 328 (MH+)
131 4-amino-6-(2-fluoro-5-methyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 276 (MH+)
132 4-amino-6-(2,4,6-trimethyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 286 (MH+)
133 4-amino-6-(3-chloro-2-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 292 (MH+)
134 4-amino-6-(3-methylsulfanyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 290 (MH+)
135 4-amino-6-[3-(l-methoxyimino-ethyl)-phenylamino]-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 315 (MH+)
136 4-amino-6-(3,5-dimethyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 272 (MH+)
137 N- {4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-phenyl} - acetamide MS m/z 301 (MH+)
138 4-amino-6-phenylamino-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 244 (MH+)
139 4-amino-6-(4-morpholin-4-yl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 329 (MH+)
140 4-amino-6-o-tolylamino-pyrimidine-5-carbaldehyde O-methyl-oxime
MS m/z 258 (MH+)
141 4-amino-6-(3,4-difluoro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 280 (MH+)
142 4-amino-6-(3-fluoro-4-methyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 276 (MH+) Cpd Name and Data
143 4-amino-6-(3,4-dichloro-phenylamino)-pyrimidine-5-carbaldehyde 0-methyl- oxime MS m/z 312 (MH+)
144 4-amino-6-(3-chloro-4-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 292 (MH+)
145 4-amino-6-[5-chloro-2-methyl-4-(2-oxo-2-phenyl-ethyl)-phenylammo]-pyrimidine- 5-carbaldehyde O-methyl-oxime MS m/z 410 (MH+)
146 4-amino-6-(3-ethyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime
MS m/z 272 (MH+)
147 4-amino-6-(4-isopropyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 286 (MH+)
148 4-amino-6-(lH-indol-5-ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime
MS m/z 283 (MH+)
149 4-amino-6-(3-trifluoromethyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 312 (MH+)
150 4-amino-6-m-tolylamino-pyrimidine-5-carbaldehyde O-methyl-oxime
MS m/z 258 (MH+)
151 4-amino-6-(4-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime
MS m/z 278 (MH+)
152 4-amino-6-(4-chloro-2-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 292 (MH+)
153 4-amino-6-(4-phenylamino-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 335 (MH+)
154 4-amino-6-(4-diethylamino-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 315 (MH+)
155 4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-benzoic acid methyl ester MS m/z 302 (MH+)
156 4-ammo-6-[4-(methoxyimino-phenyl-methyl)-phenylammo]-pyrimidine-5- carbaldehyde O-methyl-oxime MS m/z 377 (MH+)
157 4-(4-acetyl-phenylamino)-6-amino-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 286 (MH+)
158 4-amino-6-[4-(l-methoxyimino-ethyl)-phenylamino]-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 315 (MH+)
159 {4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-phenyl}-acetonitrile MS m/z 283 (MH+)
160 4-amino-6-(2-methoxy-4-phenylamino-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 365 (MH+)
161 N-{4-[6-amino-5-(methoxyimino-methyl)-pyrimidm-4-ylammo]-3-methoxy- phenylj-acetamide MS m/z 331 (MH+)
162 4-amino-6-(4-cyclohexyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 326 (MH+) Cpd Name and Data
163 4-amino-6-(naphthalen- 1 -ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 294 (MH+)
164 4-amino-6-(4-chloro-naphthalen- 1 -ylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 328 (MH+)
165 4-amino-6-(2,4-difluoro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 280 (MH+)
166 4-amino-6-(2-methylsulfanyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 290 (MH+)
167 4-amino-6-(3-fluoro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 262 (MH+)
168 4-amino-6-(3,5-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 276 (MH+)
169 4-amino-6-(3,5-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 312 (MH+)
170 4-amino-6-(5-chloro-2-methoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 308 (MH+)
171 4-amino-6-(5-chloro-2-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 292 (MH+)
172 4-amino-6-(4-fluoro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 262 (MH+)
173 4-amino-6-(biphenyl-4-ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 320 (MH+)
174 4-amino-6-(4-methylsulfanyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 290 (MH+)
175 4-amino-6-(3,5-dimethoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 304 (MH+)
176 4-amino-6-(3,4,5-trimethoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 334 (MH+)
177 4-amino-6-(3,4-dimethoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 304 (MH+)
178 4-amino-6-(5,6,7,8-tetrahydro-naphthalen- 1 -ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 298 (MH+)
179 4-[6-ammo-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-pyrimidm-2-yl- benzenesulfonamide MS m/z 401 (MH+)
180 3-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-benzoic acid ethyl ester MS m/z 316 (MH+)
181 {4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-benzyl}-phosphonic acid diethyl ester MS m/z 394 (MH+)
182 4-amino-6-(4-ethyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime
MS m/z 272 (MH+) Cpd Name and Data
183 4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-(3,5-dimethyl- pyrazin-2-yl)-benzenesulfonamide MS m/z 429 (MH+) 184 4-amino-6-(2-methyl-benzothiazol-5-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime MS m/z 315 (MH+) 185 4-amino-6-[4-(4-methoxy-phenylamino)-phenylamino]-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 365 (MH+) 186 4-amino-6-(4-dimethylamino-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 287 (MH+) 187 4-[6-amino-5-(methoxyimmo-methyl)-pyrimidm-4-ylamino]-N-(2-diethylammo- ethyl)-benzamide MS m/z 386 (MH+) 188 4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-benzoic acid butyl ester MS m/z 344 (MH+) 189 4-amino-6-(indan-4-ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 284 (MH+) 190 4-amino-6-(4'-chloro-biphenyl-4-ylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime MS m/z 354 (MH+) 191 4-amino-6-[6-(4-fluoro-phenoxy)-pyridin-3-ylamino]-pyrimidine-5-carbaldehyde O-methyl-oxime MS m/z 355 (MH+) 192 4'-[6-amino-5-(methoxyimmo-methyl)-pyrimidm-4-ylammo]-biphenyl-4- carboxylic acid methyl ester MS m/z 378 (MH+)
Example 2
4-amino-6-(4-benzyloxy-3 -chloro-phenylamino)-pyrimidine-5 - carbonitrile (Cpd 118)
Figure imgf000117_0001
A solution of 4,6-dichloro-pyrimidine-5-carbonitrile Compound 2a (82 mg, 0.47 mmol), Et3N (0.13 mL, 0.94 mmol) and 4-benzyloxy-3-chloro-phenylamine Compound 2b (110 mg, 0.47 mmol) in THF (4.7 mL) was stirred at 25 0C for 3 hours. The reaction mixture was diluted with EtOAc (50 mL), washed with water (1 x 50 mL) and concentrated to afford 4-(4-benzyloxy-3-chloro-phenylamino)-6-chloro- pyrimidine-5-carbonitrile Compound 2c (175 mg, 100%) as an off-white solid; 1H NMR (300 MHz, CD3OD) δ 8.42 (s, IH), 7.63 (s, IH), 7.52-7.40 (m, 7H), 7.12 (m, IH), 5.22 (s, 2H), 5.19 (s, 2); MS (ESI) m/z: 373 (MH+).
Figure imgf000118_0001
A suspension of Compound 2c (10 mg, 0.027 mmol) in 2M NH3 in MeOH (0.26 mL) was warmed at reflux for 1 hour. The reaction mixture was cooled and concentrated. The resulting residue was dissolved in EtOAc (25 mL) and washed with water (15 mL). The organic layer was dried using Na2SO4 and concentrated to afford Compound 118 (5 mg, 50%) as a yellow solid. 1H NMR (400 MHz, CD3OD) δ 8.05 (s, IH), 7.57 (s, IH), 7.48 (d, J = 7.2 Hz, 2H), 7.37-7.29 (m, 4H), 7.11 (d, J = 8.8 Hz, IH), 5.19 (s, 2).
Using the procedure of Example 2, other compounds representative of the present invention may be prepared:
Name
4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-pyrimidine-5- carbonitrile
4-amino-6-[2-(3-fluoro-benzyl)-lH-benzoimidazol-5-ylamino]-pyrimidine-5- carbonitrile
4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5-carbonitrile
4-amino-6-(4-phenoxy-phenylamino)-pyrimidine-5-carbonitrile
4-amino-6-(3-chloro-4-fluoro-phenylamino)-pyrimidine-5-carbonitrile Example 3
4-[3-Chloro-4-(3-fluoro-benzyloxy)-phenylamino]-6- methylamino-pyrimidine-5-carbaldehyde O-methyl-oxime
(Compound 39)
Figure imgf000119_0001
A solution of 4,6-dichloro-pyrimidine-5-carbaldehyde Compound Ia (100 mg, 0.57 mmol) in CHCl3 (1 mL) was treated with methylamine (0.31 mL, 0.63 mmol, 2.0 M in THF) at RT under air. After Ih the solvent was removed in vacuo and the product, 4-chloro-6-methylamino-pyrimidine-5-carbaldehyde Compound 3a was used in the next step without further purification. LC/MS (m/z) [M+ 1]+ 172 (calculated for C6H6ClN3O, 171.58).
Figure imgf000119_0002
Crude 4-chloro-6-methylamino-pyrimidine-5-carbaldehyde Compound 3a was dissolved into DMSO (1 mL) and treated with 3-chloro-4-(3-fluoro-benzyloxy)- phenylamine Compound 3b (157 mg, 0.63 mmol). The resulting solution was heated to 90 0C for 2h 40 min. Conversion of starting materials to 4-[3-chloro-4-(3-fluoro- benzyloxy)-phenylamino]-6-methylamino-pyrimidine-5-carbaldehyde Compound 3c was verified by LC/MS; (m/z) [M+l]+ 387 (calculated for Ci9Hi6ClFN4O2, 386.81). The reaction solution was carried on directly to the next step without workup.
Figure imgf000120_0001
The reaction solution of Compound 3c was removed from the heating block, then methoxylamine hydrochloride (142 mg, 1.7 mmol) was added and heating resumed at 90 0C for Ih. The crude reaction was cooled to RT, partitioned between EtOAc (30 mL) and H2O (20 mL), the organic phase was dried over Na2SO4, then concentrated in vacuo. Purification on the Chromatotron radial, thin-layer chromatograph (https://www.chromatotron.com/chromatotron/specs.html) (1 mm, 20% EtOAc/CH2Cl2) afforded the product 4-[3-chloro-4-(3-fluoro-benzyloxy)- phenylamino]-6-methylamino-pyrimidine-5-carbaldehyde O-methyl-oxime Compound 39 as a yellow oil (4.7 mg, 0,01 mmol). 1H NMR (300 Hz, CDCl3) δ 8.99 (bs, IH), 8.31 (bs, IH), 8.26 (s, IH), 7.54 (d, J = 2.5 Hz, IH), 7.38-7.17 (m, 4H), 7.04-6.90 (m, 2H), 5.13 (s, 2H), 3.97 (s, 3H), 3.13 (d, J= 4.9 Hz, 3H); LC/MS (m/z) [M+l]+ 416.1 (calculated for C20Hi9ClFN5O2, 415.85).
Using the procedure of Example 3, other compounds representative of the present invention were prepared:
Cpd Name and Data
40 (5£)-4-ethylamino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (300 Hz, CDCl3) δ 8.97 (bs, IH), 8.23 (s, IH), 8.21 (bs, IH), 8.02 (s, IH), 7.83 (s, IH), 7.37-7.23 (m, 4H), 6.97-6.95 (m, 2H), 6.86-6.81 (m, IH), 5.58 (s, 2H), 3.95 (s, 3H), 3.63-3.59 (m, 2H), 1.29 (t, J = 7.2 Hz, 3H); LC/MS (m/z) (MH+) 420.1 (calculated for C22H22FN7O, 419.46) Cpd Name and Data
41 (5£)-4-ethylamino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime
1H NMR (300 Hz, CDCl3) δ 9.07 (bs, IH), 8.24 (s, IH), 8.22 (bs, IH), 8.02 (s, IH), 7.83 (s, IH), 7.34-7.23 (m, 4H), 6.97-6.95 (m, 2H), 6.86-6.82 (m, IH), 5.58 (s, 2H), 4.19 (q, J = 7.05, 2H), 3.64-3.57 (m, 2H), 1.33-1.27 (m, 6H); LC/MS (m/z) (MH+) 434.2 (calculated for C23H24FN7O, 433.48)
42 (5£)-4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-6-ethylamino-pyrimidine- 5-carbaldehyde O-methyl-oxime
1H NMR (300 Hz, CDCl3) δ 8.86 (bs, IH), 8.24 (s, 2H), 7.56 (d, J = 2.61 Hz, IH), 7.39-7.37 (m, 4H), 7.17-7.03 (m, IH), 6.93-6.90 (m, IH), 6.44 (bs, IH), 5.13 (s, 2H), 3.98 (s, 3H), 3.59 (m, 2H), 1.28 (t, J = 7.23 Hz, 3H); LC/MS (m/z) (MH+) 430.1 (calculated for C2iH21ClFN5O2, 429.88)
43 (5£)-4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-6-ethylamino-pyrimidine- 5-carbaldehyde O-ethyl-oxime
1H NMR (300 Hz, CDCl3) δ 8.75 (bs, IH), 8.25 (s, IH), 8.24 (s, IH), 7.59 (d, J = 2.57 Hz, IH), 7.35-7.18 (m, 4H), 7.04-6.98 (m, IH), 6.91-6.88 (m, IH), 6.18 (bs, IH), 5.12 (s, 2H), 4.23 (q, J = 7.05 Hz, 2H), 3.56 (m, 2H), 1.35 (t, J = 7.05 Hz, 3H), 1.26 (t, J = 7.14 Hz, 3H); LC/MS (m/z) (MH+) 444.1 (calculated for C22H23ClFN5O2, 443.90)
53 (5£)-4-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-6-methylamino-pyrimidine-5- carbaldehyde O-methyl-oxime
1H NMR (SOO Hz, CDCl3) δ 8.65 (bs, IH), 8.31 (s, IH), 8.26 (s, IH), 8.01 (s, IH), 7.85 (d, J = 1.74 Hz, IH), 7.39-7.22 (m, 3H), 6.97-6.94 (m, 2H), 6.41-6.37 (m, IH), 5.57 (s, 2H), 3.97 (s, 3H), 3.09 (d, J = 4.80 Hz, 3H); LC/MS (m/z) (MH+) 406.1 (calculated for C2iH20FN7O, 405.43)
Example 4
(5E)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)- pyrimidine-5 -carbaldehyde 0-(2-morpholin-4-yl-ethyl)-oxime
(Cpd 78)
Figure imgf000121_0001
To a 100 L reactor equipped with nitrogen sweep, thermocouple and condensers was added 2-methoxy-ethanol (66.5 kg), 4-amino-6-chloro-pyrimidine-5-carbaldehyde Compound Ib (5.98 kg), 4-benzyloxy-3-chloro-phenylamine Compound Ic (5.98 kg), 6N HCl (1.54 kg) and purified water (0.55 kg). The reactor wall was rinsed with 2- methoxy-ethanol (0.5 kg). The slurry was heated to about 40 0C and aged for 15 minutes. A second addition of Compound Ic (3.09 kg) was made and the reaction mixture was aged for an additional 15 minutes. The slurry solution then crystallized. A third addition of Compound Ic (3.08 kg) was made and the reaction mixture was aged for 15 minutes. The slurry was heated to about 650C until HPLC analysis showed the reaction was complete, thus providing 4-amino-6-(4-benzyloxy-3-chloro- phenylamino)-pyrimidine-5-carbaldehyde Compound Id which was used in the next step as an unisolated intermediate.
Figure imgf000122_0001
The slurry containing Compound Id was cooled to between about 20-25 0C, then O-(2-morpholin-4-yl-ethyl)-hydroxylamine dihydrochloride Compound 4a (9.37 kg) and 6.0N NaOH solution (12.1 L) was added. The suspension was heated to reflux between about 105 0C to about 115 0C and the distillate (between about 38.5 to about 43.5 kg) was collected. The slurry was cooled to between about 20 0C to about 25 0C, then 2-methoxy-ethanol (18.5 kg) and purified water (19.1 kg) was added. The resulting slurry was stirred for 0.5 h, then filtered on an 18" polypropylene filter lined with polypropylene cloth. The filter cake was washed thrice with a mixture (1 :1 v/v) of 2-methoxy-ethanol (15.1 kg) and water (13.9 kg). The wet cake was dried on the filter for at least 30 minutes then transferred to polypropylene drying trays, weighed and covered with polypropylene tray covers. The product was dried to a constant weight at between about 55 0C to about 6O0C under vacuum with a nitrogen bleed to provide Compound 78 (13.79 kg, 81% yield) as a yellow powder. 98.9 HPLC Area %, 99.6 HPLC wt. % vs. standard.
Compound 78 (11.00 kg), 1-propanol (44.2 kg) and water (55.0 kg) was added to a 100 L reactor equipped with nitrogen sweep, thermocouple, and condensers. The resulting suspension was heated until a solution was achieved (at about 70 0C). The solution was cooled to between about 60 0C to about 650C and the contents were polish filtered to another 100 L reactor using a 145-175 micron filter. The solution was cooled to about 10 0C over a period of about 3.5 hours and then aged for about one hour. The suspension was filtered on an 18" polypropylene filter lined with polypropylene cloth and the resulting cake was washed twice each with a 1 : 1 (v/v) mixture of 1-propanol/water (19.8 kg). The filter cake was dried with nitrogen for at least 30 minutes on the filter and then transferred to polypropylene drying trays, weighed and covered with polypropylene tray covers. The product was dried to a constant weight at between about 55 0C to about 6O0C under vacuum with a nitrogen bleed to provide the mono hydrochloride salt of Compound 78 (9.60 kg, 87% yield) as a light yellow powder. 99.0 HPLC Area %, 99.8 HPLC wt.% vs. standard.
The present invention is further directed to a method for selectively coupling an aniline compound with a chlorinated pyrimidine aldehyde compound.
The first step of the foregoing Example 4 is representative of this method whereby an aniline compound reacts with a chlorinated pyrimidine aldehyde compound at the chloro substituted carbon atom instead of at the aldehyde. This coupling is induced by using a catalytic amount of acid. Acids that may be used in the present method include, and are not limited to, aqueous HCl. Solvents that may be used in the present method include, and are not limited to, 2-methoxy-ethanol. Example 5
N-(4-benzyloxy-3 -chloro-phenyl)-5 - [5 -(2-morpholin-4-yl-ethyl)- [l,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine (Cpd 193)
Figure imgf000124_0001
4-amino-6-(4-benzyloxy-3 -chloro-phenylamino)-pyrimidine-5 -carbaldehyde
Compound Id (5.0 g, 14.1 mmol) in THF /MeOH (1/1, 125 mL) was treated with MnO2 (7.4 g, 84.5 mmol), NaCN (2.1 g, 42.3 mmol), AcOH (2.4 mL, 42.3 mmol) and the reaction mixture was warmed at reflux for 24 h. The mixture was cooled to rt and filtered through Celite. The filtrate was diluted with H2O (200 mL) and then extracted with a (1/1) mixture of EtOAc/THF (3 x 100 mL). The resulting organic extracts were dried (Na2SO4), and concentrated to afford 4-amino-6-(4-benzyloxy-3-chloro- phenylamino)-pyrimidine-5-carboxylic acid hydrazide Compound 5a (4.33 g, 80%) as a yellow solid. 1H NMR (300 MHz, DMSO-J6) δ 10.26 (s, IH), 8.05 (s, IH), 7.86 (d, J = 2.4 Hz, IH), 7.64 (br s, 2 H), 7.51-7.35 (m, 7H), 7.20 (d, J = 8.7 Hz, IH), 5.22 (s, 2H), 3.89 (s, 3H).
Figure imgf000124_0002
A suspension of Compound 5a (4.3 g, 11.2 mmol) in 100% EtOH (110 niL) was treated with hydrazine (6.8 rnL, 224 mol) and warmed at reflux for 24 h. The reaction mixture was concentrated onto SiO2 (15 g). The residue was purified via column chromatography (Horizon 65+M, 0-10% MeOH/DCM) to provide 4-amino-6-(4- benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carboxylic acid hydrazide Compound 5b (2.50 g, 58%) as a yellow solid. 1H NMR (300 MHz, CD3OD) δ 7.96 (s, IH), 7.61 (d, J = 2.0 Hz, IH), 7.64-7.22 (m, 6H), 7.04 (d, J = 8.7 Hz, IH), 5.22 (s, 2H); MS m/z 385.0 (MH+).
Figure imgf000125_0001
A mixture of Compound 5b (6.8 mg, 0.018 mmol), 3-morpholin-4yl-propionic acid hydrochloride (3.8 mg, 0.019 mmol) and EDCI (10.2 mg, 0.053 mmol) in DMF (0.17 mL) was stirred at rt for 12 h. The reaction was diluted with H2O (20 mL) and extracted with EtOAc (3 x 10 mL). The combined organic extracts were dried (Na2SO4) and concentrated to afford 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)- pyrimidine-5-carboxylic acid N'-(3-morpholin-4-yl-propionyl)-hydrazide Compound 5c (8.3 mg, 88%) as a yellow solid. 1H NMR (400 MHz, CD3OD) δ 8.03 (s, IH), 7.76 (d, J = 1.2 Hz, IH), 7.47-7.30 (m, 6H), 7.05 (d, J = 6.4 Hz, IH), 5.15 (s, 2H), 2.76 (m, 2H), 2.56 (m, 6H), 1.29 (br s, 6H); MS m/z 526.5 (MH+).
Figure imgf000126_0001
A solution of Compound 5c (6.2 mg, 0.012 mmol) in DCM (0.20 niL) was treated with Et3N (3.3 μL), then toluene sulfonyl chloride (2.4 mg, 0.012 mmol) was added and the resulting solution was stirred at rt for 3 h. The reaction was loaded directly onto a SiO2 column (Horizon 12+M, 0-5% MeOH/DCM) to afford Compound 193 (5.0 mg, 85%) as a white solid. 1H NMR (400 MHz, CD3OD) δ 8.09 (s, IH), 7.75 (d, J = 2.7 Hz, IH), 7.47-7.32 (m, 6H), 7.13 (d, J = 9.0 Hz, IH), 5.17 (s, 2H), 3.67 (m, 4H), 3.29 (t, J = 1.5 Hz, 2H), 2.87 (t, J = 6.9 Hz, 2H), 2.55 (m, 4H); MS m/z 508.2 (MH+).
Biological Examples
The ability of the compounds for treating, preventing or ameliorating a chronic or acute kinase mediated disease, disorder or condition was determined using the following procedures.
Example 1 EGFR Kinase Assay
The EGFR kinase used was a fusion of Glutathione-S-Transferase (GST) and a PCR amplified intracellular portion of EGFR (NM 005228). The intracellular portion of EGFR started at nucleotide 2189 (corresponding to amino acid 667) and ended at the termination codon. The portion was PCR amplified with primers that added the lambda attB sequences to each end, recombined into an entry vector, then into a GST destination vector (as described in Gateway Technologies Manual by Invitrogen Corporation , Carlsbad, California).
The destination vector was recombined in the DHlOBAC strain of bacteria to produce a bacmid. The bacmid was transfected into Sf 9 cells and the supernatant containing the baculovirus was collected. The GSTEGFR protein was purified using large cultures of Sf 9 cells infected with stock virus. After an appropriate period of time, the cells were collected and lysed. The GSTEGFR was then purified from the lysate on Glutathione-Sepharose columns (as described by Amersham Biosciences, Buckinghamshire, United Kingdom). The EGFR substrate was prepared by biotinylating polyGluTyr (128 mg)
(Sigma , St. Louis, Missouri) in a IX PBS buffer incubated together with a 12-fold molar excess of Sulfo-NHS-LC-Biotin on ice for at least 2 hrs. The free biotin was separated from the biotinylated polyGluTyr on a gel filtration column.
A mixture of a 1OX kinase buffer (500 mM Tris at pH 8.0, 100 mM Magnesium Chloride and 1 mM Sodium Vanadate), DTT (1 mM final from 500 mM stock), ATP (5 μM final from 10 mM stock), biotinylated polyGluTyr (10 μg/μL stock), γ-33P ATP (10 μCi/μL stock) and water was added to each well (90 μL/well) of a Streptavidin Flashplate (Perkin Elmer, Wellesley, MA).
Test compound in 100% DMSO (2 μL) was added to the appropriate wells. Diluted GSTEGFR (1 :300 dilution in 50 mM Tris at pH 8.0 and 0.1% bovine serum albumin) (10 μL) was added to the wells to initiate the reactions.
The plates were incubated at 30 0C for 1 hr with shaking. The reacted contents were removed and the plates were sequentially washed three times with a IX PBS stop buffer (300 μL without Magnesium and Calcium) and 100 mM EDTA. After the final wash, the same stop buffer (200 μL) was added to the wells. The plates were then sealed and read on the TopCount scintillation counter.
Test compounds were assayed in triplicate at 16 concentrations at half- log dilutions starting at 200 μM. A maximum and minimum signal for the assay was determined on each plate. The percent inhibition of a test compound was calculated according to the formula (max signal - test compound) ]
— : : : — : — (100) = % inhibition
(max signal - mm signal) J
For a series of test concentrations, the IC50 was derived by graphing percent inhibition against the log of the concentrations tested for a given compound. The EGFR IC50 results are shown in Table 1. Values shown as % indicate % inhibition at a test concentration of 2 μM.
Table 1
EGFR IC50 (μM) Cpd IC50 Cpd IC50 Cpd IC50
1 0.07 41 0.4 77 0.02
2 0.008 42 7.8 78 0.02
3 1.1 43 1.4 79 0.008
4 0.01 44 0.07 80 0.3
5 0.5 45 0.05 82 0.2
7 0.05 46 0.02 84 0.01
9 0.02 47 0.01 85 0.02
10 0.005 48 0.04 87 0.03
11 0.008 49 0.03 88 0.009
12 0.04 50 0.02 91 0.007
13 0.2 51 0.04 92 0.05
14 0.1 54 0.02 93 0.02
16 0.01 55 0.04 94 0.02
17 0.02 56 0.3 95 0.05
18 0.03 57 0.2 96 0.06
19 0.02 58 0.03 97 0.03
20 1.2 59 0.05 98 0.02
21 1.5 60 0.05 99 0.07
22 0.3 61 0.2 100 0.02
23 1.9 62 0.2 102 0.04
24 0.09 63 1.2 108 0.2
25 0.03 65 0.04 111 0.1
28 0.9 66 0.1 112 0.02
29 0.2 67 0.1 118 0.03
30 0.03 68 0.01 120 15% Cpd IC50 Cpd IC50 Cpd IC50
31 0.02 69 0.01 122 6%
32 0.01 70 0.02 123 7%
33 0.02 71 0.01 124 26%
34 0.01 74 0.06 125 42%
36 0.02 75 0.008 128 45%
37 0.02 76 0.01 129 1%
38 0.1
Example 2 HER-2 Kinase Assay
The HER-2 kinase used was purified at Proqinase (Freiburg, Germany) from a construct that consisted of a fusion of GST (Glutathione-S-Transferase), HIS6-Thrombin and the nucleotides encoding amino acids 679 to 1255 of HER-2 (Accession Number Ml 1730).
A mixture of a 1OX kinase reaction buffer (600 mM Hepes at pH 7.5, 30 mM Magnesium Chloride, 0.03 mM Sodium Vanadate and 500 μg/mL PEG 20,000), DTT (1.2 mM final from a 10 mM stock), ATP (1 μM from a 10 mM stock), biotinylated polyGluTyr (1.5 ng/μL final from stock of 1 μg/μL) prepared by Upstate
Biotechnologies, Lake Placid, New York), Manganese Chloride (3 mM final from a 1 M stock), γ-33P-ATP (10 μCi/μL stock) and water (70 μL/well) was added to each well of a Streptavidin Flashplate (Cat. # SMP 103, NEN, Boston, MA).
Test compound stock (1 μL) was added to the appropriate wells. Diluted GSTHER2 kinase (6.7 ng/μL diluted into 50 mM Tris-HCl at pH 8.0 and 0.1% bovine serum albumin) (30 μL) was added (total volume of 200 ng/well) to initiate the reactions.
The reaction plates were incubated at 30 0C for 1 hr. The reaction was terminated by aspirating the reaction mixture from the plate wells and washing the wells three times with a IX PBS stop buffer (300 μL) and 100 mM EDTA. After the final wash, the same stop buffer (200 μL) was again added to the wells. The plates were then sealed and read on the TopCount scintillation counter.
Test compounds were assayed in triplicate at 8 concentrations at one-log dilutions starting at 100 μM. A maximum and minimum signal for the assay was determined on each plate. The percent inhibition of a test compound was calculated according to the formula:
(max signal - test compound)
1 (100) = % inhibition
(max signal - min signal)
For a series of test concentrations, the IC50 was derived by graphing percent inhibition against the log of the concentrations tested for a given compound. The Her-2 IC50 values are shown in Table 2. Values shown as % indicate % inhibition at a test concentration of 1 μM.
Table 2 HER2 IC50 (μM)
Cpd IC50 Cpd IC50 Cpd IC50
1 0.2 40 10.6 84 0.04
2 0.01 41 3.6 85 0.02
3 5.2 42 100 86 100
4 0.02 43 10.4 87 0.07
5 3.7 44 1.6 88 0.02
6 0.1 45 0.4 89 10.0
7 0.1 46 0.1 90 100
8 0.7 47 0.03 91 0.03
9 0.2 48 0.02 92 0.03
10 0.007 49 0.01 93 0.008
11 0.01 50 0.04 94 0.04
12 0.05 51 0.04 95 0.2
13 0.1 52 4.5 96 0.1
14 3.1 53 10.0 97 1.0
15 100 54 0.03 98 0.1
16 0.01 55 0.03 99 0.2
17 0.6 60 0.08 100 10.0
18 0.04 63 1.0 101 0.06
19 0.05 64 100 102 0.14
20 14.1 65 0.2 103 100
21 5.3 66 0.2 104 100 Cpd IC50 Cpd IC 50 Cpd IC 50
22 4.1 67 0.2 105 100
23 28.5 68 0.006 106 100
24 0.2 69 0.004 107 10.0
25 0.3 70 0.02 108 1.1
26 100 71 0.05 109 100
27 100 72 100 110 10.0
28 5.5 73 2.9 111 0.3
29 0.2 74 0.3 118 0.1
30 0.2 75 0.009 119 >10
31 0.3 76 0.03 120 7.923
32 0.09 77 0.1 121 >10
33 0.1 78 0.06 122 >100
34 0.03 79 0.01 123 >100
35 100 80 100 124 2.46
36 0.6 81 100 125 25%
37 0.09 82 100 128 1.822
38 0.05 83 100 129 >100
39 14.8
Example 3 In Vitro Cell Proliferation Inhibition Assays
The ability of a test compound to inhibit unregulated in vitro cell proliferation may be determined by measuring incorporation of 14C-labelled thymidine into newly synthesized DNA within cell lines derived from carcinomas originating from several tissues. Accordingly, the effect of a test compound on proliferation of cells with a variety of phenotypes may be determined.
Carcinoma cell lines used include the HeLa cervical adenocarcinoma from the American Type Culture Collection (ATCC Cat. #CCL2), SK-OV-3 ovarian carcinoma (ATCC Cat. #HTB-77), MCF-7 breast carcinoma (ATCC Cat. # HTB-22), BT474 breast carcinoma (ATCC Cat. #HTB-20), SKBR3 breast carcinoma (ATCC Cat. #HTB-30), A431 epidermoid carcinoma (ATCC Cat. #CRL-1555) and NCI-N87 gastric carcinoma (ATCC Cat. #CRL-5822).
The carcinoma cells are trypsinized and counted. The cells (3000-8000 count) are added to each well of a 96-well CytoStar tissue culture treated scintillating microplate (Amersham #RPNQ0160) in complete medium (100 μL) and the plate is then incubated in complete medium for 24 hrs at 37 0C in an inert atmosphere containing 5% CO2. Test compound (1 μL) in 100% DMSO is added to the plate test- wells with
DMSO only added to control- wells. The plate is incubated in complete medium for a second 24 hr period at 37 0C in an atmosphere containing 5% CO2.
An aliquot of a solution of Methyl 14C-thymidine (56 mC/mmol) (NEN #NEC568 or Amersham #CFA532) and complete medium (20 μL to provide 0.2 μCi/well) is then added to each well and the plate is incubated for a third 24 hr period at 370C in an atmosphere containing 5% CO2.
The plate contents are then discarded, the plate is washed twice with PBS (200 μL) and then PBS (200 μL) is added to each well. The plate is sealed and the degree of methyl 14C-thymidine incorporation is quantified on a Packard Top Count. Cell proliferation of the HeIa cell line was measured using the ATP-Lite method as described in the ATP Lite Kit (Perkin-Elmer Kit Number 6106941) or the C14 method as described above. Cell proliferation of the other cell lines was measured using the C14 method.
The IC50 values for the compounds tested in various cell lines are shown in Tables 3 and 4. The term "NT" means that the compound indicated was not tested in a particular cell line. The lack of such testing is not intended to imply a belief that the compound is not otherwise active in a particular cell line or any other cell line not tested.
Table 3
HeLa IC50 (μM)
Cpd IC50 Cpd IC50 Cpd IC50
9 35.0 84 4.9 98 100
19 10.0 85 15.6 99 100
34 3.5 86 100 100 10.0
46 100 87 4.9 101 25.1
60 10.0 88 10.9 102 1.4 Cpd IC 50 CCppdd IICC 5500 Cpd IC 50
70 10.0 89 10.0 103 10.0
75 40.1 90 10.0 104 10.0
76 59.4 91 9.4 105 100
77 10.0 92 4.7 106 10.0
78 19.6 93 22.1 107 100
79 100 94 6.1 108 10.0
80 100 95 12.1 109 100
81 10.0 96 14.7 110 33.1
82 100 97 100 118 100
83 3.6
Table 4
IC so (μM)
Cpd SK-OV-3 MCF-7 BT474 SKBR3 N87 A431
9 100 86.6 NT NT 0.7 NT
19 19.1 2.5 0.03 0.1 0.04 1.1
34 3.2 3.8 NT NT 0.2 NT
46 NT NT 0.1 0.3 10.0 100
60 10.0 10.0 NT NT 0.6 NT
70 NT NT 0.1 0.4 0.3 14.2
75 10.0 30.7 NT NT 0.001 NT
76 24.1 10.0 0.2 0.3 0.3 1.8
78 100 100 0.06 0.2 0.2 0.8
87 NT NT 0.3 0.5 0.3 3.6
91 5.4 10.0 0.2 0.3 0.2 1.3
92 NT NT 0.2 0.4 0.2 3.1
93 100 100 0.04 0.02 0.07 0.6
94 1.0 1.0 0.5 0.5 0.4 NT
95 2.4 1.0 10.0 10.0 1.1 100
96 15.3 2.1 0.2 0.4 0.2 0.8
99 NT NT 10.0 100 100 100
101 NT NT 0.05 0.06 0.03 0.009
102 NT NT 0.9 0.7 0.2 0.001
118 NT NT 100 100 100 100 Example 4 N87 Human Tumor Xenograft Model
The N87 gastric carcinoma cell line overexpresses HER-2 as a result of gene amplification and forms tumors in nude mice (Kasprzyk PG, Song SU, Di Fiore PP, King CR, Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies, Cancer Res., 1992, 52, 2771-2776).
Female nu/nu mice (Charles River; 8 to 9 weeks of age) were implanted subcutaneously with from 3 x 106 to 5 x 106 N87 gastric carcinoma cells (obtained from the American Type Culture Collection , ATCC Cat. #CRL-5822).in the flank. Animals were weighed twice weekly during the study and examined frequently.
Tumor size was monitored twice weekly and then daily as the neoplasms reached the target weight range (about 75 mg). Animals were pair-matched when tumors were in the 62 to 126 mg range (group mean tumor size: 70 to 74 mg). Estimated tumor weight was calculated using the formula:
(width2) (length)
Tumor Weight = 2
A test compound was orally administered daily in the test treatment group after the tumor reached the target weight. For treatment group 1 , the test compound was administered once daily for 35 days. For treatment group 2, the test compound was administered once daily for 30 days. For treatment group 3, each dose of test compound was administered once daily for 30 days. For treatment group 4, each dose of test compound was administered once daily for 36 days. For treatment group 5-10, the test compound was administered once daily for 30 days.
Tumor weight was measured daily for subjects (n=8) in the test group and the matched subjects (n=8) in the vehicle-treated group. The tumor growth inhibition (in percent) was calculated on the last day of the study using the formula: / mean tumor weight \ / mean tumor weight \ \ vveehhiiccllee g grroouupp / / \\ tteesstt g grroouupp / Tumor Growth Inhibition = X 100% mean tumor weight vehicle group
The results for the study are shown in Table 5. Statistical significance was evaluated by comparing the vehicle group to the test group using a two tailed Students t test. The term "NC" means that the P value for the treatment group indicated was not calculated. The lack of such calculation is not intended to imply a belief that the activity of the compound is not otherwise statistically significant in this particular cell line or in any other cell line not tested.
Table 5 N87 Tumor Growth Inhibition
Treatment „ , Dose ™~T „ ,
„ Cpd , „ . TGI P value
Group (mg/kg)
1 78 100 71.0% 0.006
2 78 100 69.4% 0.003
3 78 100 59.56% 0.044
3 78 50 50.56% 0.025
3 78 25 41.29% 0.023
4 78 100 49.3% 0.007
4 78 50 33.9% 0.02
4 78 25 6.5% 0.04
5 93 100 59.9% NC
6 94 100 47.1% NC
7 101 100 66% NC
8 112 100 48.6% NC
9 114 100 47% NC
10 115 100 50.2% NC
Example 5
A431 Human Tumor Xenograft Model
The A431 epidermoid carcinoma cell line overexpresses EGFR, activating signaling pathways responsible for driving the proliferation, invasion and survival of cancer cells and forming tumors in nude mice (Giard DJ, Aaronson SA, Todaro GJ, Arnstein P, Kersey JH, Dosik H, Parks WP, In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors, J. Natl. Cancer Inst., 1973, 51, 1417-1423; and, Kawamoto T, Sato JD, Le A, Polikoff J, Sato GH, Mendelsohn J, Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody, Proc. Natl. Acad. Sci. USA, 1983, 80, 1337-1341).
Female nu/nu mice (Charles River; 8 to 9 weeks of age) were implanted subcutaneously in the flank with 4 x 106 A431 epidermoid carcinoma cells (obtained from the American Type Culture Collection , ATCC Cat. #CRL-1555). Animals were weighed twice weekly during the study and examined frequently.
Tumor size was monitored twice weekly and then daily as the neoplasms reached the target weight range (about 75 mg). Animals were pair-matched when tumors were in the 62 to 126 mg range (group mean tumor size: 70 to 74 mg). Estimated tumor weight was calculated using the formula of Example 4. A test compound was orally administered daily in the test treatment group after the tumor reached the target weight. For treatment groups 1 and 2, each dose of test compound was administered once daily for 25 days. For treatment group 3, each dose of test compound was administered twice daily for 25 days. For treatment group 4, the test compound was administered twice daily for 30 days. For treatment group 5-10, the test compound was administered once daily for 30 days.
Using the formula of Example 4, tumor weight was measured daily for subjects (n=8) in the test group and the matched subjects (n=8) in the vehicle-treated group. Using the formula of Example 4, tumor growth inhibition (in percent) was calculated on the last day of the study. The results for the study are shown in Table 6. Statistical significance was evaluated by comparing the vehicle group to the test group using a two tailed Students t test. The term "NC" means that the P value for the treatment group indicated was not calculated. The lack of such calculation is not intended to imply a belief that the activity of the compound is not otherwise statistically significant in this particular cell line or in any other cell line not tested. Table 6
A431 Tumor Growth Inhibition
Treatment Dose Group P TGI P value (mg/kg)
1 78 100 66.8% 0.025
1 78 30 10.6% 0.553
2 78 100 34.6% 0.216
2 78 50 14.3% 0.571
3 78 100 51.1% 0.038
3 78 50 45.12% 0.106
4 78 100 52% 0.048
5 93 100 64.0% NC
6 94 100 66% NC
7 101 100 51% NC
8 112 100 33% NC
9 114 100 -3% NC
10 115 100 4% NC
Example 6
BT474 Human Tumor Xenograft Model The BT474 human tumor cell line overexpresses HER-2 and forms tumors in immunocompromised mice (Rabindran SK, Discafani CM, Rosfjord EC, Baxter M, Floyd MB, Golas J, Hallett WA, Johnson BD, Nilakantan R, Overbeek E, Reich MF, Shen R, Shi X, Tsou HR, Wang YF and Wissner A, Antitumor Activity of HKI-272, an Orally Active, Irreversible Inhibitor of the HER-2 Tyrosine Kinase, Cancer Res., 2004, 64, 3958-3965).
Immunocompromised CB.17 SCID female mice were subcutaneously implanted in the hindflank with 1 mm3 BT474 breast carcinoma tumor fragments. Animals were weighed twice weekly during the study and examined frequently.
Tumor size was monitored twice weekly and then daily as the neoplasms reached the target weight range (about 75 mg). Animals were pair-matched when tumors were in the 62 to 126 mg range (group mean tumor size: 70 to 74 mg). Estimated tumor weight was calculated using the formula of Example 4. A test compound was orally administered daily in the test treatment group after the tumor reached the target weight. For treatment group 1, each dose of test compound was administered once daily for 25 days. For treatment groups 2 and 3, each dose of test compound was administered twice daily for 30 days. Using the formula of Example 4, tumor weight was measured daily for subjects
(n=15 for group 1, n=10 for groups 2 and 3) in the test groups and the matched subjects (n=8) in the vehicle-treated group. Using the formula of Example 4, tumor growth inhibition (in percent) was calculated on the last day of the study.
The results for the study are shown in Table 7. Statistical significance was evaluated by comparing the vehicle group to the test group using a two tailed Students t test.
Table 7 BT474 Tumor Growth Inhibition
Treatment „ Dose ™~T „ ,
„ Cpd , „ . TGI P value
Group (mg/kg)
1 78 50 27% 0.100
2 78 100 52% 0.004 3 78 200 62% 0.035
Example 7 Blood-Brain Barrier Penetration
The blood-brain barrier penetration of Compound 78 was examined in male Sprague Dawley rats following i.v. (3 mg/kg) or oral (10 mg/kg) administration.
The i.v. formulation consisted of a 1 mg/mL dose in vehicle (10% solutol in D5W at pH 3) with plasma samples drawn at 0.25 hours, 0.5 hours and 1 hour after administration.
The oral (p.o) formulation consisted of a 1 mg/mL dose in vehicle (0.5% methylcellulose) with plasma samples drawn at 0.5 hours, 1 hour and 2 hours after administration. The plasma samples (0.5 ml) were collected and centrifuged (2000 rpm, 3 min), then stored at -6O0C until LC-MS/MS analysis. Brain samples were collected immediately after the last blood sample collection. The samples were rinsed with 0.9% NaCl, patted dry, then weighed and placed in Falcon 14 mL polypropylene round- bottom tubes containing 3 mL methanol. The methanolic mixtures were homogenized with an OMNI THl 15 homogenizer then centrifuged for 10 minutes at 7,000 rpm. The supernatant was removed and stored frozen in 15 mL polyethylene tubes at -6O0C until LC-MS/MS analysis.
Table 8 Concentration in Plasma (ng/mL) and Brain (ng/g)
Administration Mean + SEM Brain/Plasma Ratio p. o. 60 min (plasma) 73.6 + 16.4 p.o. 120 min (brain) 46.1 + 17.4 1.2 p.o. 120 min (brain) 51.16 + 13.71 i.v. 60 min (plasma) 124.1 + 5.5 i.v. 60 min (brain) 306.9 ± 55
While the foregoing specification teaches the principles of the present invention, with examples provided for the purpose of illustration, it will be understood that the practice of the invention encompasses all of the usual variations, adaptations and modifications as come within the scope of the following claims and their equivalents.
Throughout this application, various publications are cited. These publications are hereby incorporated by reference in their entirety into this application to describe more fully the state of the art to which this invention pertains.

Claims

What is claimed is:
1. A compound of Formula (I)
Figure imgf000140_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl; Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-
C3-12cycloalkyl;
RA is selected from C=N-O-Ri or cyano or an Ri substituted oxadiazole;
Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy,
Ci_8alkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, d-salkoxy-Ci-salkyl-amino-Ci-salkyl, Ci_8alkyl-sulfonyl-Ci_8alkyl, Ci.galkyl-sulfonyloxy-Ci.galkyl, aryl, aryl-Ci_galkyl, aryloxy-Ci.galkyl, heterocyclyl-Ci.galkyl, heterocyclyl-carbonyl-Ci.galkyl, benzofused- heterocyclyl-Ci_8alkyl or heteroaryl-Ci_8alkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci.galkyl, Ci_galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl, and wherein heterocyclyl-Ci_galkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl;
R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and R-3, R4, R5, RO and R7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci-salkoxy, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci-salkyl, halo-Ci_8alkyl, hydroxy-Ci-salkoxy, halo-Ci_8alkoxy, cyano-Ci_8alkyl, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, Ci.salkyl-amino-Ci.salkyl-amino-carbonyl, Ci.galkoxy-imino-Ci.galkyl,
Ci_8alkoxy-imino-(aryl)Ci_8alkyl, carboxy, Ci.gacyl, Ci.gacyl-amino, Ci.galkoxycarbonyl, thio-Ci.galkyl, substituted phosphonic acid, C3-i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_galkoxy, wherein aryl, aryloxy, aryl-amino, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_galkyl, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, carboxy, Ci_sacyl or Ci-salkoxycarbonyl.
2. A compound of Formula (II):
Figure imgf000142_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl;
Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused- C3_i2cycloalkyl, wherein the benzene ring portion of the benzofused ring system is attached to the L variable;
RA is selected from C=N-O-Ri or cyano;
Ri is selected from hydrogen, Ci_8alkyl, Ci_8alkenyl, Ci_8alkoxy,
Ci-galkoxy-Ci-galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, d-galkoxy-Ci-galkyl-amino-Ci-galkyl, Ci_galkyl-sulfonyl-Ci_galkyl, Ci_8alkyl-sulfonyloxy-Ci_8alkyl, aryl, aryl-Ci_8alkyl, aryloxy-Ci_8alkyl, heterocyclyl-Ci.salkyl, heterocyclyl-carbonyl-Ci_8alkyl or heteroaryl-Ci_8alkyl, wherein aryl-Ci_8alkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci_8alkyl, Ci_8alkoxy, amino, Ci_8alkyl-amino or Ci_8alkoxycarbonyl, and wherein heterocyclyl-Ci_8alkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_8alkyl, Ci_8alkoxy, amino, Ci_8alkyl-amino or Ci_8alkoxycarbonyl;
R2 is selected from hydrogen, Ci_8alkyl or Ci_8alkoxy; and R-3, R4, R5, RO and R7 is each selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci-salkoxy, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci-salkyl, halo-Ci_8alkyl, hydroxy-Ci-salkoxy, halo-Ci_8alkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, carboxy, Ci_sacyl, Ci_galkoxycarbonyl, C3_i2cycloalkyl, aryl, aryloxy, aryl-Ci.galkyl, aryl-Ci_galkoxy, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_8alkoxy or heterocyclyl, wherein aryl, aryloxy, aryl-Ci_8alkyl and aryl-Ci_8alkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_8alkyl, Ci_salkoxy, amino,
Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_salkoxycarbonyl, and wherein heteroaryl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_8alkyl, amino-Ci_8alkyl, Ci-salkyl-amino-Ci-salkyl, carboxy,
Ci_gacyl or Ci_galkoxycarbonyl.
3. A compound of formula (Ia):
Figure imgf000143_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl; Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy,
Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl,
Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl, Ci_8alkyl-sulfonyl-Ci_8alkyl, Ci.galkyl-sulfonyloxy-Ci.galkyl, aryl, aryl-Ci_galkyl, aryloxy-Ci_galkyl, heterocyclyl-Ci.galkyl, heterocyclyl-carbonyl-Ci_galkyl, benzofused- heterocyclyl-Ci.galkyl or heteroaryl-Ci_galkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl, and wherein heterocyclyl-Ci_galkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl;
R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and R3, R4, R5, R6 and R7 is each selected from hydrogen, halogen, hydroxy,
Ci_galkyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino,
Ci.galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3-i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_galkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_galkyl, amino-Ci_galkyl, Ci-galkyl-amino-Ci-galkyl, carboxy, Ci_gacyl or Ci_galkoxycarbonyl.
4. A compound of formula (Ib):
Figure imgf000145_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl;
-X-Y-Z- is a moiety selected from -N(R3)-N=C(R3)-, =N-N(R3)-C(R3)=, -N(R3)-C(R3)=C(R3)-, -C(R3)2-C(R3)2-C(R3)2-, -O-C(R3)2-O-, -N(R3)-C(R3)=N-, -O-C(R3)=C(R3)-, -N(R3)-C(R3)2-C(R3)2- or -S-C(R3)=N-; wherein the dashed lines in formula (Ib) represent the locations for one or two double bonds when present in the moiety;
Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy,
Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, hydroxy-Ci_galkoxy, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, d-galkoxy-Ci-galkyl-amino-Ci-galkyl, Ci_galkyl-sulfonyl-Ci_galkyl, Ci_8alkyl-sulfonyloxy-Ci_8alkyl, aryl, aryl-Ci_8alkyl, aryloxy-Ci_8alkyl, heterocyclyl-Ci_8alkyl, heterocyclyl-carbonyl-Ci_8alkyl, benzofused- heterocyclyl-Ci_8alkyl or heteroaryl-Ci_8alkyl, wherein aryl-Ci_8alkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci_8alkyl, Ci_8alkoxy, amino, Ci_8alkyl-amino or Ci_8alkoxycarbonyl, and wherein heterocyclyl-Ci_8alkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_8alkyl, Ci_8alkoxy, amino, Ci_8alkyl-amino or Ci_8alkoxycarbonyl; R2 is selected from hydrogen, Ci_8alkyl or Ci_8alkoxy; and
R3 is selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci_8alkoxy, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_8alkyl, halo-Ci_8alkyl, hydroxy-Ci_8alkoxy, halo-Ci_8alkoxy, cyano-Ci_8alkyl, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_8alkoxy-imino-Ci_8alkyl,
Ci_8alkoxy-imino-(aryl)Ci_8alkyl, carboxy, Ci_sacyl, Ci_8acyl-amino, Ci.salkoxycarbonyl, thio-Ci_salkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_8alkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_salkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl or Ci_galkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from d_8alkyl, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, carboxy, Ci_sacyl or Ci-salkoxycarbonyl.
5. A compound of formula (Ic):
Figure imgf000147_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl;
Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused- C3-i2cycloalkyl;
R2 is selected from hydrogen, Ci_8alkyl or Ci-salkoxy; and
R3, R4, R5, Re and R7 is each selected from hydrogen, halogen, hydroxy, Ci.galkyl, Ci.galkoxy, Ci.galkoxy-Ci-galkyl, hydroxy-Ci_galkyl, halo-Ci_8alkyl, hydroxy-Ci_8alkoxy, halo-Ci_8alkoxy, cyano-Ci_8alkyl, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, Ci-salkyl-amino-Ci-salkyl-amino-carbonyl, Ci_8alkoxy-imino-Ci_8alkyl, Ci_8alkoxy-imino-(aryl)Ci_8alkyl, carboxy, Ci_8acyl, Ci_8acyl-amino, Ci_salkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3-i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_8alkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci-salkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci.galkoxy, wherein aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl and aryl-Ci_8alkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_galkyl, Ci_8alkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_salkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_galkyl, amino-Ci_galkyl,
Ci-galkyl-amino-Ci-galkyl, carboxy, Ci_gacyl or Ci_galkoxycarbonyl. wherein heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one or two Ci_galkyl substituents.
6. A compound of formula (Id):
Figure imgf000148_0001
and forms thereof, wherein
L is selected from a bond, Ci_6alkyl or halo-Ci_6alkyl;
R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and
R3, R4, R5, Re and R7 is each selected from hydrogen, halogen, hydroxy,
Ci_galkyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_galkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_8alkyl, Ci_8alkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_salkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_salkyl, amino-Ci_galkyl, Ci-galkyl-amino-Ci-galkyl, carboxy, Ci_gacyl or Ci_galkoxycarbonyl.
7. A compound of formula (Ie):
Figure imgf000149_0001
and forms thereof, wherein
L is selected from a bond, C^alkyl or halo-Ci_6alkyl;
-X-Y-Z- is a moiety selected from -N(R3)-N=C(R3)-, =N-N(R3)-C(R3)=,
-N(R3)-C(R3)=C(R3)-, -C(R3)2-C(R3)2-C(R3)2-, -O-C(R3)2-O-, -N(R3)-C(R3)=N-, -O-C(R3)=C(R3)-, -N(R3)-C(R3)2-C(R3)2- or
-S-C(R3)=N-; wherein the dashed lines in formula (Ie) represent the locations for one or two double bonds when present in the moiety;
R2 is selected from hydrogen, Ci_8alkyl or Ci_8alkoxy; and
R3 is selected from hydrogen, halogen, hydroxy, Ci_8alkyl, Ci_8alkoxy, Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_8alkyl, halo-Ci_8alkyl, hydroxy-Ci-galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl, Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_8alkoxy-imino-(aryl)Ci_8alkyl, carboxy, Ci_8acyl, Ci_8acyl-amino, Ci_8alkoxycarbonyl, thio-Ci_8alkyl, substituted phosphonic acid,
C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_8alkyl, aryl-Ci_8alkoxy, aryl-carbonyl-Ci_8alkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_8alkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_8alkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_8alkyl and aryl-Ci_8alkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_8alkyl, Ci_8alkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl,
Ci_8alkyl-amino-Ci_8alkyl or Ci_8alkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from d_8alkyl, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl, carboxy, Ci_gacyl or Ci_galkoxycarbonyl.
8. A compound of formula (If) :
Figure imgf000151_0001
and forms thereof, wherein
Xi and X2 is each selected from -C(Re)- or -N-, wherein Xi and X2 are not the same;
L is selected from a bond, C^alkyl or halo-Ci_6alkyl;
Ri is selected from hydrogen, Ci_galkyl, Ci_galkenyl, Ci_galkoxy,
Ci_8alkoxy-Ci_8alkyl, hydroxy-Ci_8alkyl, hydroxy-Ci_8alkoxy, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl,
Ci.galkoxy-Ci-galkyl-amino-Ci.galkyl, Ci_8alkyl-sulfonyl-Ci_8alkyl, Ci.galkyl-sulfonyloxy-Ci.galkyl, aryl, aryl-Ci_8alkyl, aryloxy-Ci_galkyl, heterocyclyl-Ci.galkyl, heterocyclyl-carbonyl-Ci_galkyl, benzofused- heterocyclyl-Ci.galkyl or heteroaryl-Ci_galkyl, wherein aryl-Ci_galkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, Ci_galkyl, Ci_galkoxy, amino, Ci_galkyl-amino or Ci_galkoxycarbonyl, and wherein heterocyclyl-Ci_galkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, Ci_8alkyl, Ci_galkoxy, amino, Ci_8alkyl-amino or Ci_galkoxycarbonyl; R2 is selected from hydrogen, Ci_galkyl or Ci_galkoxy; and
R3, R4, and R5 is each selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci.galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl, Ci_galkyl-amino-Ci_galkyl,
Ci.galkyl-amino-Ci.galkyl-amino-carbonyl, Ci_galkoxy-imino-Ci_galkyl, Ci_galkoxy-imino-(aryl)Ci_galkyl, carboxy, Ci_gacyl, Ci_gacyl-amino, Ci_galkoxycarbonyl, thio-Ci_galkyl, substituted phosphonic acid, C3_i2cycloalkyl, aryl, aryloxy, aryl-amino, aryl-Ci_galkyl, aryl-Ci_galkoxy, aryl-carbonyl-Ci_galkyl, aryl-amido, heteroaryl, heteroaryloxy, heteroaryl-Ci_galkoxy, heteroaryl-amino-sulfonyl, benzofused-heterocyclyl or heterocyclyl, wherein phosphonic acid is substituted on the phosphorous atom with two substituents selected from hydroxy or Ci_galkoxy, wherein aryl, aryl-amino, aryloxy, aryl-Ci_galkyl and aryl-Ci_galkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, hydroxy, Ci_8alkyl, Ci_8alkoxy, amino, Ci_8alkyl-amino, amino-Ci_8alkyl, Ci_8alkyl-amino-Ci_8alkyl or Ci_salkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, heteroaryl-amino-sulfonyl and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from Ci_salkyl, amino-Ci_galkyl, Ci-galkyl-amino-Ci-galkyl, carboxy, Ci_gacyl or Ci_galkoxycarbonyl; and
R6 is selected from hydrogen, halogen, hydroxy, Ci_galkyl, Ci_galkoxy, Ci_galkoxy-Ci_galkyl, hydroxy-Ci_galkyl, halo-Ci_galkyl, hydroxy-Ci_galkoxy, halo-Ci_galkoxy, cyano-Ci_galkyl, amino, Ci_galkyl-amino, amino-Ci_galkyl or Ci_galkyl-amino-Ci_galkyl.
The compound of claim 1 selected from the group consisting of (5£)-4-amino-6-(3-chloro-4-fluoro-phenylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
(5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino)- pyrimidine-5 -carbaldehyde O-methyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(2-morpholin-4-yl-2-oxo-ethyl)-oxime,
(5£)-4-amino-6-(3 -methoxy-4-phenoxy-phenylamino)-pyrimidine-5 - carbaldehyde O-methyl-oxime,
(5£)-4-amino-6-(3 -methoxy-4-phenoxy-phenylamino)-pyrimidine-5 - carbaldehyde O-(2-morpholin-4-yl-2-oxo-ethyl)-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-ethyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-allyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-tert-butyl-oxime,
(5£)-4-amino-6-[3 -methyl-4-(pyridin-3 -yloxy)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
(5£)-4-amino-6-[(lS)-l-phenyl-ethylamino]-pyrimidine-5-carbaldehyde O- ethyl-oxime,
(5£)-4-amino-6-(lH-indol-5-ylamino)-pyrimidine-5 -carbaldehyde O-ethyl- oxime,
(5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino)- pyrimidine-5 -carbaldehyde O-ethyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
(5£)-4-amino-6-(4-phenoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
(5£)-4-amino-6-(4-benzyloxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
(5£)-4-amino-6-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-isobutyl-oxime, (5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde 0-(2-phenoxy-ethyl)-oxime,
(5£)-4-amino-6-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
(5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime,
(5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
(5£)-4-amino-6-(3 -bromo-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-ethyl-oxime,
(5£)-4-amino-6-[3 -chloro-4-(pyridin-3 -yloxy)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(4-methoxy-benzyl)-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde 0-(2-methoxy-benzyl)-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-benzyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde 0-isopropyl-oxime,
(5£)-4-amino-6-(l -benzyl- 1 H-indazol-5 -ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
(5£)-4-amino-6-(l -benzyl- 1 H-indazol-5 -ylamino)-pyrimidine-5- carbaldehyde O-ethyl-oxime,
3-{5-[6-amino-(5£)-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]- indazol- 1 -ylmethyl} -benzonitrile,
3-{5-[6-amino-(5£)-5-(ethoxyimino-methyl)-pyrimidin-4-ylamino]-indazol- 1 -ylmethyl} -benzonitrile,
(5£)-4-amino-6-[l-(3-chloro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
(5£)-4-amino-6-[l-(3-chloro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-ethyl-oxime,
(5£)-4-amino-6-[2-(3-fluoro-benzyl)-lH-benzoimidazol-5-ylamino]- pyrimidine-5 -carbaldehyde O-ethyl-oxime,
(5£)-4-amino-6-(3 -chloro-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime, (5£)-4-amino-6-[2-(3-fluoro-benzyl)-lH-benzoimidazol-5-ylamino]- pyrimidine-5 -carbaldehyde 0-methyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde 0-phenyl-oxime,
(5£)-4-amino-6- [ 1 -(4-fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
(5£)-4-amino-6- [ 1 -(4-fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-ethyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(2-methoxy-ethyl)-oxime,
(5Z)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indazol-5-ylamino]-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(3 -dimethylamino-propyl)-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2-methoxy-ethyl)-oxime,
(5£)-4-amino-6-[l-(3-fluoro-benzyl)-2,3-dihydro-lH-indol-5-ylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
(5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde 0-(3-hydroxy-propyl)-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(3 -hydroxy-propyl)-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime monohydrochloride salt,
(5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(3 -hydroxy-propyl)-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(3-morpholin-4-yl-propyl)-oxime,
(5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde oxime, (5£)-4-amino-6-[ 1 -(3 -fluoro-benzyl)- 1 H-indol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(3 -hydroxy-propyl)-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(3 -piperidin- 1 -yl-propyl)-oxime,
(5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
(5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2 -piperidin- 1 -yl-ethyl)-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(2 -piperidin- 1 -yl-ethyl)-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(2 -piperidin- 1 -yl-ethyl)-oxime,
(5£)-4-amino-6-[3-chloro-4-(3,5-difluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
(5£)-4-amino-6-[3-chloro-4-(3,5-difluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde oxime,
(5£)-4-amino-6-[3-chloro-4-(3,5-difluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
(5£)-4-amino-6-[( 1 S)- 1 -phenyl-ethylamino] -pyrimidine-5 -carbaldehyde oxime,
(5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
(5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2 -piperidin- 1 -yl-ethyl)-oxime,
(5£)-4-amino-6-(4-phenoxy-phenylamino)-pyrimidine-5-carbaldehyde oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-(3-morpholin-4-yl-propyl)-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O-pyridin-2-ylmethyl-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde O- [3 -(2-methoxy-ethylamino)-propyl] -oxime,
4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbonitrile,
Λ/-benzo[l,3]dioxol-5-ylmethyl-5-[(benzo[l,3]dioxol-5-ylmethylimino)- methyl]-pyrimidine-4,6-diamine,
4-amino-6-(4-methoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime, 4-amino-6- [(benzo[ 1 ,3 ]dioxol-5 -ylmethyl)-amino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
4-amino-6-(3 ,4-dimethoxy-benzylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-(4-phenoxy-benzylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
4-amino-6-(indan- 1 -ylamino)-pyrimidine-5 -carbaldehyde O-methyl-oxime,
4-amino-6-(l,2,3,4-tetrahydro-naphthalen-l-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
4-amino-6- [ 1 -(4-chloro-phenyl)-ethylamino] -pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6- [ 1 -(4-methoxy-phenyl)-ethylamino] -pyrimidine-5 -carbaldehyde 0-methyl-oxime,
4-amino-6-(6-phenoxy-pyridin-3 -ylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-(6-morpholin-4-yl-pyridin-3-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
4-amino-6-(l,4-dioxo-l,2,3,4-tetrahydro-phthalazin-5-ylamino)-pyrimidine- 5 -carbaldehyde 0-methyl-oxime,
4-amino-6-(2-fluoro-5 -methy l-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-(2,4,6-trimethyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(3 -chloro-2-methyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-(3 -methylsulfanyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6- [3 -( 1 -methoxyimino-ethyl)-phenylamino] -pyrimidine-5 - carbaldehyde 0-methyl-oxime,
4-amino-6-(3 ,5 -dimethy l-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
Λ/-{4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-phenyl}- acetamide,
4-amino-6-phenylamino-pyrimidine-5 -carbaldehyde O-methyl-oxime,
4-amino-6-(4-morpholin-4-yl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-o-tolylamino-pyrimidine-5-carbaldehyde O-methyl-oxime, 4-amino-6-(3 ,4-difluoro-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-(3 -fluoro-4-methy l-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-(3 ,4-dichloro-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-(3 -chloro-4-methyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-[5-chloro-2-methyl-4-(2-oxo-2-phenyl-ethyl)-phenylamino]- pyrimidine-5 -carbaldehyde O-methyl-oxime,
4-amino-6-(3 -ethyl-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
4-amino-6-(4-isopropyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(lH-indol-5-ylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
4-amino-6-(3 -trifluoromethyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-m-tolylamino-pyrimidine-5-carbaldehyde O-methyl-oxime,
4-amino-6-(4-chloro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
4-amino-6-(4-chloro-2-methyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(4-phenylamino-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(4-diethylamino-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzoic acid methyl ester,
4-amino-6- [4-(methoxyimino-phenyl-methyl)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
4-(4-acetyl-phenylamino)-6-amino-pyrimidine-5-carbaldehyde O-methyl- oxime,
4-amino-6- [4-( 1 -methoxyimino-ethyl)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
{4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-phenyl}- acetonitrile, 4-amino-6-(2-methoxy-4-phenylamino-phenylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime,
N-{4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-3- methoxy-phenyl} -acetamide,
4-amino-6-(4-cyclohexyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(naphthalen- 1 -ylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
4-amino-6-(4-chloro-naphthalen- 1 -ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(2,4-difluoro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(2-methylsulfanyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(3 -fluoro-phenylamino)-pyrimidine-5 -carbaldehyde O-methyl- oxime,
4-amino-6-(3,5-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(3,5-dichloro-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(5-chloro-2-methoxy-phenylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime,
4-amino-6-(5 -chloro-2-methyl-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-(4-fluoro-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
4-amino-6-(biphenyl-4-ylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
4-amino-6-(4-methylsulfanyl-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(3,5-dimethoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(3,4,5-trimethoxy-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-(3 ,4-dimethoxy-phenylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime,
4-amino-6-(5,6,7,8-tetrahydro-naphthalen-l-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime, 4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-pyrimidin- 2-yl-benzenesulfonamide,
3 - [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzoic acid ethyl ester,
{4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-benzyl}- phosphonic acid diethyl ester,
4-amino-6-(4-ethyl-phenylamino)-pyrimidine-5-carbaldehyde O-methyl- oxime,
4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-(3,5- dimethyl-pyrazin-2-yl)-benzenesulfonamide,
4-amino-6-(2-methyl-benzothiazol-5-ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime,
4-amino-6- [4-(4-methoxy-phenylamino)-phenylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
4-amino-6-(4-dimethylamino-phenylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-N-(2- diethylamino-ethyl)-benzamide,
4- [6-amino-5 -(methoxyimino-methyl)-pyrimidin-4-ylamino] -benzoic acid butyl ester,
4-amino-6-(indan-4-ylamino)-pyrimidine-5-carbaldehyde O-methyl-oxime,
4-amino-6-(4'-chloro-biphenyl-4-ylamino)-pyrimidine-5-carbaldehyde O- methyl-oxime,
4-amino-6-[6-(4-fluoro-phenoxy)-pyridin-3-ylamino]-pyrimidine-5- carbaldehyde O-methyl-oxime,
4'-[6-amino-5-(methoxyimino-methyl)-pyrimidin-4-ylamino]-biphenyl-4- carboxylic acid methyl ester, and
N-(4-benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)- [l,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine.
10. The compound of claim 1 selected from the group consisting of
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-methyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-ethyl-oxime,
(5£)-4-amino-6- [ 1 -(3 -fluoro-benzyl)- 1 H-indazol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-allyl-oxime, (5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5-carbaldehyde 0-(3-hydroxy-propyl)-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde 0-(2-morpholin-4-yl-ethyl)-oxime,
(5£)-4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5- carbaldehyde 0-(2-morpholin-4-yl-ethyl)-oxime monohydrochloride salt,
(5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5-carbaldehyde oxime,
(5£)-4-amino-6-[ 1 -(3 -fluoro-benzyl)- 1 H-indol-5 -ylamino] -pyrimidine-5 - carbaldehyde oxime,
(5£)-4-amino-6-[ 1 -(3 -fluoro-benzyl)- 1 H-indol-5 -ylamino] -pyrimidine-5 - carbaldehyde O-(3 -hydroxy-propyl)-oxime,
(5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
(5£)-4-amino-6-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]- pyrimidine-5 -carbaldehyde 0-(2-piperidin- 1 -yl-ethyl)-oxime,
(5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-morpholin-4-yl-ethyl)-oxime,
(5£)-4-amino-6-[l-(3-fluoro-benzyl)-lH-indol-5-ylamino]-pyrimidine-5- carbaldehyde O-(2-piperidin- 1 -yl-ethyl)-oxime,
4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbonitrile,
4-amino-6-(l,2,3,4-tetrahydro-naphthalen-l-ylamino)-pyrimidine-5- carbaldehyde O-methyl-oxime, and
4-amino-6-(6-phenoxy-pyridin-3 -ylamino)-pyrimidine-5 -carbaldehyde O- methyl-oxime.
11. The compound of claim 1 wherein the compound is an isolated form thereof.
12. A pharmaceutical composition comprising an effective amount of the compound of claim 1.
13. The pharmaceutical composition of claim 12 wherein the effective amount of the compound is in a range of from about 0.001 mg/kg to about 300 mg/kg of body weight per day.
14. A process for preparing a pharmaceutical composition comprising the step of admixing the compound of claim 1 and a pharmaceutically acceptable carrier.
15. A compound as claimed in any of claims 1 - 10 for use as a medicine.
16. Use of a compound as claimed in any of claims 1 - 10 for use in the manufacture of a medicament for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
17. A product containing (a) a pharmaceutical composition containing an effective amount of a chemotherapeutic agent and a pharmaceutical acceptable carrier, and (b) a pharmaceutical composition containing an effective amount of a compound of claim 1 , and a pharmaceutical acceptable carrier, as a combined preparation for simultaneous, separate or sequential use in oncological disorders.
18. A compound as claimed in any of claims 1 - 10 for use as a medicament for treating cancer.
19. A compound as claimed in any of claims 1 - 10 for use as a medicament for treating cancer in patients that are receiving radiotherapy.
20. A process for preparing the compound of claim 1 comprising the steps of:
a. reacting a compound of Formula A4 with NH2OH hydrochloride to provide a compound of Formula A5, representative of the compound of claim 1 :
Figure imgf000162_0001
b. reacting a mixture of the compound of Formula A5 and a basic reagent with a compound of Formula A6 (wherein Ql is a halogen leaving group) to provide a compound of Formula A7, representative of the compound of claim 1 :
Figure imgf000163_0001
C. reacting the compound of Formula A7 with a compound of Formula A8 (wherein Q2 is a halogen leaving group) to provide a compound of Formula A9, representative of the compound of claim 1 :
Figure imgf000163_0002
d. metabolizing the compound of Formula A9 to provide a compound of Formula AlO, representative of the compound of claim 1 :
Figure imgf000163_0003
21. A process for preparing the compound of claim 1 comprising the step of reacting a solution of a compound of Formula C4 with a reagent mixture to provide a compound of Formula C5, representative of the compound of claim 1 :
Figure imgf000164_0001
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