WO2006059194A3 - Pharmaceutical sustained-release composition containing clozapine - Google Patents

Pharmaceutical sustained-release composition containing clozapine Download PDF

Info

Publication number
WO2006059194A3
WO2006059194A3 PCT/IB2005/003437 IB2005003437W WO2006059194A3 WO 2006059194 A3 WO2006059194 A3 WO 2006059194A3 IB 2005003437 W IB2005003437 W IB 2005003437W WO 2006059194 A3 WO2006059194 A3 WO 2006059194A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition containing
release composition
pharmaceutical sustained
containing clozapine
clozapine
Prior art date
Application number
PCT/IB2005/003437
Other languages
French (fr)
Other versions
WO2006059194A2 (en
Inventor
Enrico Malizia
Original Assignee
Unihart Corp
Enrico Malizia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unihart Corp, Enrico Malizia filed Critical Unihart Corp
Publication of WO2006059194A2 publication Critical patent/WO2006059194A2/en
Publication of WO2006059194A3 publication Critical patent/WO2006059194A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed is a slow-release solid oral pharmaceutical composition containing clozapine, and its use in the treatment of psychotic disorders.
PCT/IB2005/003437 2004-11-19 2005-11-16 Pharmaceutical sustained-release composition containing clozapine WO2006059194A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002232A ITMI20042232A1 (en) 2004-11-19 2004-11-19 PHARMACEUTICAL COMPOSITION CONTAINING CLOZAPINE
ITMI2004A002232 2004-11-19

Publications (2)

Publication Number Publication Date
WO2006059194A2 WO2006059194A2 (en) 2006-06-08
WO2006059194A3 true WO2006059194A3 (en) 2006-08-31

Family

ID=36565404

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003437 WO2006059194A2 (en) 2004-11-19 2005-11-16 Pharmaceutical sustained-release composition containing clozapine

Country Status (2)

Country Link
IT (1) ITMI20042232A1 (en)
WO (1) WO2006059194A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019004892A2 (en) 2016-09-17 2019-06-11 Intas Pharmaceuticals Ltd clozapine extended release pharmaceutical composition in multiparticulate form and process for the preparation of a clozapine extended release pharmaceutical composition
EP3520803A1 (en) 2018-01-31 2019-08-07 Zarodex Therapeutics Limited Novel uses
SG11202005712SA (en) 2018-01-31 2020-07-29 Zarodex Therapeutics Ltd Clozapine for the treatment of a immunoglobulin driven b cell disease
WO2019149863A1 (en) 2018-01-31 2019-08-08 Zarodex Therapeutics Limited Clozapine for the treatment of ig-e driven b cell diseases
GB201910873D0 (en) 2019-07-30 2019-09-11 Zarodex Therapeutics Ltd Novel uses
US11648207B1 (en) 2021-12-15 2023-05-16 Intas Pharmaceuticals Ltd. Extended release pharmaceutical composition of Clozapine
US11918590B2 (en) 2021-12-15 2024-03-05 Intas Pharmaceuticals Ltd. Stable extended release pharmaceutical composition of clozapine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871778A (en) * 1992-11-17 1999-02-16 Yoshitomi Pharmaceutical Industries, Ltd. Sustained release microsphere preparation containing antipsychotic drug
US6197764B1 (en) * 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871778A (en) * 1992-11-17 1999-02-16 Yoshitomi Pharmaceutical Industries, Ltd. Sustained release microsphere preparation containing antipsychotic drug
US6197764B1 (en) * 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VENKATESWARLU V ET AL: "Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 95, no. 3, 24 March 2004 (2004-03-24), pages 627 - 638, XP004496400, ISSN: 0168-3659 *

Also Published As

Publication number Publication date
ITMI20042232A1 (en) 2005-02-19
WO2006059194A2 (en) 2006-06-08

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