WO2005041877A3 - Method of inhibiting rejection following organ transplantation - Google Patents

Method of inhibiting rejection following organ transplantation Download PDF

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Publication number
WO2005041877A3
WO2005041877A3 PCT/US2004/035874 US2004035874W WO2005041877A3 WO 2005041877 A3 WO2005041877 A3 WO 2005041877A3 US 2004035874 W US2004035874 W US 2004035874W WO 2005041877 A3 WO2005041877 A3 WO 2005041877A3
Authority
WO
WIPO (PCT)
Prior art keywords
organ transplantation
rejection following
following organ
inhibiting rejection
organ
Prior art date
Application number
PCT/US2004/035874
Other languages
French (fr)
Other versions
WO2005041877A9 (en
WO2005041877A2 (en
Inventor
David M Briscoe
Marlies Reinders
Original Assignee
Childrens Medical Center
David M Briscoe
Marlies Reinders
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center, David M Briscoe, Marlies Reinders filed Critical Childrens Medical Center
Publication of WO2005041877A2 publication Critical patent/WO2005041877A2/en
Publication of WO2005041877A3 publication Critical patent/WO2005041877A3/en
Publication of WO2005041877A9 publication Critical patent/WO2005041877A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention is directed to methods for inhibiting organ/graft rejection. Preferably, the method comprises administering to a donor, prior to transfer of donor tissue, an effective amount of VEGF antagonist. The VEGF antagonist may also be administered to the organ recipient. In addition, an immunosuppressant and/or chemokine antagonist may also be administered to the organ donor and/or the recipient.
PCT/US2004/035874 2003-10-29 2004-10-28 Method of inhibiting rejection following organ transplantation WO2005041877A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51525403P 2003-10-29 2003-10-29
US60/515,254 2003-10-29

Publications (3)

Publication Number Publication Date
WO2005041877A2 WO2005041877A2 (en) 2005-05-12
WO2005041877A3 true WO2005041877A3 (en) 2005-06-16
WO2005041877A9 WO2005041877A9 (en) 2005-08-11

Family

ID=34549383

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/035874 WO2005041877A2 (en) 2003-10-29 2004-10-28 Method of inhibiting rejection following organ transplantation

Country Status (1)

Country Link
WO (1) WO2005041877A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980952B2 (en) 2002-03-20 2015-03-17 University Of Maryland, Baltimore Methods for treating brain swelling with a compound that blocks a non-selective cation channel
ES2807274T3 (en) 2002-03-20 2021-02-22 Univ Maryland A non-selective cation channel in neural cells and channel-blocking compounds for use in treating inflammation of the brain
ATE486606T1 (en) 2004-09-18 2010-11-15 Univ Maryland THERAPEUTIC AGENTS FOR TARGETING THE NCCA ATP CHANNEL AND METHOD OF USE THEREOF
GB0427827D0 (en) * 2004-12-20 2005-01-19 Randox Lab Ltd Method of diagnosis
WO2008089103A2 (en) * 2007-01-12 2008-07-24 University Of Maryland, Baltimore Targeting ncca-atp channel for organ protection following ischemic episode
EP2125895B1 (en) * 2007-02-02 2015-04-08 Vegenics Pty Ltd Vegf receptor antagonists for treating organ transplant alloimmunity and arteriosclerosis
CA3065983C (en) 2007-06-22 2022-07-26 The United States Of America As Represented By The Department Of Veterans Affairs Inhibitors of ncca-atp channels for therapy
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
US20140050694A1 (en) * 2012-08-20 2014-02-20 Wisconsin Alumni Research Foundation Method of Treating Transplant Rejection and Autoimmune Diseases
WO2014189635A1 (en) * 2013-05-20 2014-11-27 The Trustees Of Columbia University In The City Of New York Tracking donor-reactive tcr as a biomarker in transplantation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547959A (en) * 1992-12-22 1996-08-20 American Home Products Corporation Innovative technique for immunosuppression involving administration of rapamycin loaded formed blood elements
WO1998051344A1 (en) * 1997-05-12 1998-11-19 The Kennedy Institute Of Rheumatology Suppression of tumor necrosis factor alpha and vascular endothelial growth factor in therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547959A (en) * 1992-12-22 1996-08-20 American Home Products Corporation Innovative technique for immunosuppression involving administration of rapamycin loaded formed blood elements
WO1998051344A1 (en) * 1997-05-12 1998-11-19 The Kennedy Institute Of Rheumatology Suppression of tumor necrosis factor alpha and vascular endothelial growth factor in therapy

Also Published As

Publication number Publication date
WO2005041877A9 (en) 2005-08-11
WO2005041877A2 (en) 2005-05-12

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