WO2004045404A1 - Dispositif et procede de mesure de cavites corporelles - Google Patents

Dispositif et procede de mesure de cavites corporelles Download PDF

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Publication number
WO2004045404A1
WO2004045404A1 PCT/DK2003/000792 DK0300792W WO2004045404A1 WO 2004045404 A1 WO2004045404 A1 WO 2004045404A1 DK 0300792 W DK0300792 W DK 0300792W WO 2004045404 A1 WO2004045404 A1 WO 2004045404A1
Authority
WO
WIPO (PCT)
Prior art keywords
signal
catheter
transducer
body cavity
pressure
Prior art date
Application number
PCT/DK2003/000792
Other languages
English (en)
Inventor
Steen B. Rasmussen
Peter Foged
Original Assignee
Rhinometrics A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhinometrics A/S filed Critical Rhinometrics A/S
Priority to AU2003281973A priority Critical patent/AU2003281973A1/en
Priority to EP03773579A priority patent/EP1581108A1/fr
Publication of WO2004045404A1 publication Critical patent/WO2004045404A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters

Definitions

  • the invention relates to the examination and measurement of passages and cavities in the human or animal body, and in particular of irregularities such as constrictions by means of a device comprising an electrical signal source, a catheter to be introduced into a cavity through a natural or surgically prepared opening in the body, a first transducer for transmitting an acoustic acti- vation signal from the signal source to and through the catheter, a second transducer for reception of response signals from the catheter, and a computer for analysing the response signals in relation to the activation signal.
  • a device comprising an electrical signal source, a catheter to be introduced into a cavity through a natural or surgically prepared opening in the body, a first transducer for transmitting an acoustic acti- vation signal from the signal source to and through the catheter, a second transducer for reception of response signals from the catheter, and a computer for analysing the response signals in relation to the activation signal.
  • US 5 823 965 discloses an apparatus and method for examining human or animal body cavities such as airways and the gastro-intestinal tract.
  • the device has a flexible hose-like catheter, which is introduced into the cavity with the distal end of the catheter beyond the zone to be examined.
  • An acoustical excitation signal is sent into the interior of the catheter. Irregularities reflect the acoustical signal, which is picked up by a receiving transducer and ana- lysed.
  • Such method is often referred to as reflectometric examination.
  • a computer displays results of the examination on a screen.
  • the device may comprise means for establishing a positive static pressure with the purpose of dilating the flexible wall of the measuring zone.
  • the purpose of the invention is to provide improvement in the measuring capability in such known devices.
  • the receiving transducer produces an output signal that is transmitted to the signal analysis device, e.g. a computer, where this is sampled together with the reflectometry data obtained form the reflectometry analysis.
  • the signal analysis device e.g. a computer
  • the invention further relates to a method for obtaining dynamic data of the conditions in a body cavity, the method comprising obtaining reflectometric data on the shape of the body cavity and simultaneously obtaining values of low frequency pressure alterations in the body cavity.
  • the method comprises transmitting the data obtained to a signal-processing device for simultaneous processing.
  • the data obtained from the reflectometry and the low frequency may be used to provide corresponding area and pressure representations, e.g. in a coordinate system having pressure along one axis and area along another axis.
  • the low-frequency pressure signals can be the result of corresponding changes in the volume of the body cavity due e.g. to respiration or heartbeats, which are then reflected in the analysis of the signals received from the pressure transducer.
  • the low-frequency pressure signals can be the result of low-frequency signals transmitted into the body cavity, in which case the received low-frequency signals represent the volume of the body cavity and thus also changes in the volume.
  • the cavity is an organic cavity, e.g. the respiratory passages, the blood or lymph tracts, the alimentary canal, or the urinary system or sections thereof of an animal or a human body.
  • the invention also offers the possibility of making prostate or uterus examinations etc.
  • FIG. 1 shows a block diagram of the basic lay-out of the device according to the an embodiment of invention
  • FIG. 2 is a perspective drawing of part of the catheter, at the location where the measurement is made;
  • FIG. 3 is a perspective drawing of part of the catheter in another embodiment of the invention.
  • FIG. 4 is a sectional view of the catheter according to FIG. 3 in a sectional plane at right angles to the axis of the catheter;
  • FIG. 5 illustrates the placing of a catheter in the upper airways of a patient being examined for tongue-fallback
  • FIG. 6 illustrates the placing of a catheter in the upper airways of a patient being examined for stertorous respiration.
  • FIG. 1 shows the basic layout of the device according to the invention.
  • a catheter 1 has a proximal end A and a distal end B.
  • the catheter 1 is for in- serting, with its distal B end fist, through a natural or surgically prepared opening in a human or animal body.
  • the catheter 1 is connected to auxiliary equipment, which is known per se and not illustrated, used for inserting the catheter in, e.g., the airways of a patient, through the mouth or the nostrils, or in the urinary system or an artery. After insertion the distal end B of the catheter will be in the cavity of the patient.
  • a controller 2 includes a signal generator that is adapted to give an activation signal to a transmitting transducer 3 connected to the catheter 1.
  • the signal generator delivers the same signal to a signal analysis processor 4.
  • An elec- tro-acoustic receiving transducer 5 is connected to the catheter 1.
  • the transducer 3 emits an acoustic signal that will propagate into the catheter.
  • the transducer 5 At the distal end of the catheter and at irregularities in the cross-section response signals are reflected and received by the transducer 5 and from there led to the signal analysis processor 4.
  • the system comprises a fluid pump 40 that is controlled by the controller 2 and connected to the proximal end A of the catheter through a tube 41.
  • the fluid is air.
  • the pump 40 is capable of increasing the pressure in the catheter in a controlled manner, e.g. continuously or step- wise in small increments.
  • a pressure and flow control unit 42 comprises a static and low-frequency pressure transducer 5 for monitoring the pressure in the catheter 1 , and a pressure release valve that opens at a predefined pressure and releases the pressure in the catheter to prevent overpressure.
  • the pressure and flow con- trol unit 42 may also comprise a flow control unit that detects and prevents an excessive flow of fluid in case of e.g. a ruptured catheter.
  • Static and low- frequency pressure data from the pressure transducer is transmitted to the signal analysis processor 4 for processing and/or for display.
  • the term "low frequency" is intended to cover frequencies of physical movements that occur in human and animal physiological processes of normal and pathological nature.
  • the pressure transducer preferably has an upper frequency limit of at least 10 - 100 Hz depending on the nature of the processes to be examined.
  • Low-frequency acoustic signals may be generated by the controller 2 and used to excite the transmitting transducer 3 to transmit corresponding low- frequency signals into the body cavity, or the fluid pump can be used for generating such low-frequency signals superimposed on the fluid flow or static pressure generated by the pump.
  • the low-frequency pressure transducer 5 is used to sense the resulting low-frequency pressure, which then represents the volume and changes in volume of the body cavity.
  • the invention also relates to a method for obtaining dynamic data of the con- ditions in a body cavity, where the method comprises obtaining reflectometric data on the shape of the body cavity and simultaneously obtaining values of low frequency pressure alterations in the body cavity.
  • the method may comprise transmitting the data obtained to a signal- processing device for simultaneous processing.
  • the data obtained from the reflectometry and the low frequency may be used to provide corresponding area and pressure representations, e.g. in a coordinate system having pressure along one axis and area along another axis.
  • the signal analysis processor 4 is connected to a computer 6 with a screen 7 by means of which it is possible to present an image, which e.g. graphically illustrates the results of the examination and measurements made.
  • the electro-acoustic transducer 3 can be of any suitable type known per se, e.g. an electromagnetic transducer, an electrostatic transducer, a piezoelectric transducer, etc. Its task is to transform the electronic signal from the signal generator 2 into an excitation signal in the interior of the catheter 1.
  • the electro-acoustic transducer 5 can also be of the above mentioned type, e.g. a microphone, the purpose of which is to receive an acoustic response signal from the distal end of the catheter and to transform this response sig- nal into an electrical signal which is led to the signal analysis processor 4.
  • the electro-acoustic transducers 3 and 5 in figure 1 are preferably piezoelectric transducers or other reciprocal transducers, which in response to an electrical input signal emit an acoustic output signal, and in response to an acoustic input signal emit an electrical output signal.
  • a single transducer can be used both as transmitter and receiver.
  • the analysis itself of the response signal in relation to the excitation signal belongs to a technique known per se.
  • a transducer 20 has been introduced from the outside through the outer chamber 12 and through the wall 15 so that the response signal receiving end 21 of the transducer 20 is located in the lumen 11.
  • FIG. 5 illustrates the use of the catheter in order to determine the position of and measure the so-called tongue fallback of a patient, e.g. the situation where the patient's tongue narrows the upper airways.
  • the catheter has been introduced through the nostrils and into the air passage. Part of the catheter is compressed by the rear end of the tongue in the zone D.
  • FIG. 6 illustrates the use of the catheter in order to determine the position of and measure the outbreak of vibrations in the soft palate (velum palatum).
  • FIG. 6 shows the situation illustrated in FIG. 5 as well as the situation where said soft parts of the palate compress the catheter in the zone E.
  • the sound signals may propagate not only in longitudinal modes but also in transversal modes, which will distort the measurements.
  • the invention has the essential advantage that it is the inner cavity of the catheter which constitutes the measurement cavity proper, which can have local variations, e.g. at a constriction in the passage in which the cathe- ter has been introduced.
  • the catheter of the invention prevents the occurrence of transversal modes.
  • FIG. 6 illustrates as already mentioned the situation where a patient is to be examined for vibrations in the soft parts of the palate, e.g. typically stertorous respiration.
  • the vibrations in the zone E will influence at least one of the outer chambers of the catheter and the measurement equipment can carry out the positioning and measurement.
  • Anatomical, physiological, surgical or other medical considerations may influ- ence the choice of the inner and outer dimensions of the catheter and its length, and the catheter may therefore be manufactured in different diameters and lengths.
  • An internal measurement has the advantage that the patient is not awakened during the measurements by the excitation signal and at the same time the measurements are not influenced to a large extent by the high tone sound spectrum of the snoring sounds.
  • a correct "tightening" through the nose happens automatically due to the re- flectory swallowing, and a connection (transducer/microphone part) at the end which projects out of the nose can be made without problems.
  • the measurement equipment which adequately makes the measurements in each chamber and during measurements changes the static pressure in each chamber can also concurrently give information about the elasticity of the tissue giving counter-pressure to the surface of the chambers.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

L'invention concerne un dispositif comprenant un cathéter (1) présentant une lumière, une extrémité proximale (A) et une extrémité distale fermée (B) destinée à être introduite dans la cavité corporelle d'un être humain ou d'un animal. Un générateur de signaux (2) produit un signal d'excitation et un transducteur d'émission (3) émet un signal acoustique correspondant dans la lumière du cathéter. Un transducteur de réception (5) reçoit des réflexions du signal acoustique à partir de la lumière du cathéter. Un transducteur de pression basse fréquence (42) détecte la pression dans la lumière du cathéter et émet un signal représentant des variations de la pression basse fréquence dans la lumière. Un dispositif de traitement de signaux (4, 6) reçoit et analyse les signaux de sortie provenant du transducteur de réception (5) et du transducteur de pression (42). Des informations relatives à l'élasticité des parois de la cavité corporelle peuvent être obtenues.
PCT/DK2003/000792 2002-11-19 2003-11-19 Dispositif et procede de mesure de cavites corporelles WO2004045404A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003281973A AU2003281973A1 (en) 2002-11-19 2003-11-19 Device and method for measuring in body cavities
EP03773579A EP1581108A1 (fr) 2002-11-19 2003-11-19 Dispositif et procede de mesure de cavites corporelles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200201788 2002-11-19
DKPA200201788 2002-11-19

Publications (1)

Publication Number Publication Date
WO2004045404A1 true WO2004045404A1 (fr) 2004-06-03

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ID=32319494

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000792 WO2004045404A1 (fr) 2002-11-19 2003-11-19 Dispositif et procede de mesure de cavites corporelles

Country Status (3)

Country Link
EP (1) EP1581108A1 (fr)
AU (1) AU2003281973A1 (fr)
WO (1) WO2004045404A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011115990A2 (fr) 2010-03-15 2011-09-22 University Of South Florida Stéthoscope à cathéter électronique
EP3463061A4 (fr) * 2016-05-31 2019-12-11 Sonarmed Inc. Dispositif de réflectométrie acoustique dans des cathéters
WO2021207796A1 (fr) 2020-04-16 2021-10-21 ResMed Pty Ltd Détection et/ou analyse acoustique dans un appareil de traitement respiratoire

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986003957A1 (fr) * 1985-01-10 1986-07-17 Andreas Spiegelberg Installation pour mesurer la tension
US5573007A (en) * 1994-08-08 1996-11-12 Innerspace, Inc. Gas column pressure monitoring catheters
US5823965A (en) * 1994-11-15 1998-10-20 Rhinometrics A/S Device for reflectometric examination and measurement of cavities
US5882314A (en) * 1991-12-17 1999-03-16 Biomechanics, Inc. Airway geometry imaging

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986003957A1 (fr) * 1985-01-10 1986-07-17 Andreas Spiegelberg Installation pour mesurer la tension
US5882314A (en) * 1991-12-17 1999-03-16 Biomechanics, Inc. Airway geometry imaging
US5573007A (en) * 1994-08-08 1996-11-12 Innerspace, Inc. Gas column pressure monitoring catheters
US5823965A (en) * 1994-11-15 1998-10-20 Rhinometrics A/S Device for reflectometric examination and measurement of cavities

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011115990A2 (fr) 2010-03-15 2011-09-22 University Of South Florida Stéthoscope à cathéter électronique
EP2547261A4 (fr) * 2010-03-15 2017-07-05 University Of South Florida Stéthoscope à cathéter électronique
US9782145B2 (en) 2010-03-15 2017-10-10 University Of South Florida Electronic catheter stethoscope
EP3463061A4 (fr) * 2016-05-31 2019-12-11 Sonarmed Inc. Dispositif de réflectométrie acoustique dans des cathéters
US10729621B2 (en) 2016-05-31 2020-08-04 Sonarmed Inc. Acoustic reflectometry device in catheters
EP3900616A1 (fr) * 2016-05-31 2021-10-27 Sonarmed Inc. Dispositif de réflectométrie acoustique dans des cathéters
US11654087B2 (en) 2016-05-31 2023-05-23 Covidien Lp Acoustic reflectometry device in catheters
WO2021207796A1 (fr) 2020-04-16 2021-10-21 ResMed Pty Ltd Détection et/ou analyse acoustique dans un appareil de traitement respiratoire
EP4135806A4 (fr) * 2020-04-16 2024-04-24 ResMed Pty Ltd Détection et/ou analyse acoustique dans un appareil de traitement respiratoire

Also Published As

Publication number Publication date
EP1581108A1 (fr) 2005-10-05
AU2003281973A1 (en) 2004-06-15

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