WO2003054152A3 - Novel nucleic acids and polypeptides - Google Patents

Novel nucleic acids and polypeptides Download PDF

Info

Publication number
WO2003054152A3
WO2003054152A3 PCT/US2002/039555 US0239555W WO03054152A3 WO 2003054152 A3 WO2003054152 A3 WO 2003054152A3 US 0239555 W US0239555 W US 0239555W WO 03054152 A3 WO03054152 A3 WO 03054152A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
polypeptides
novel nucleic
novel
present
Prior art date
Application number
PCT/US2002/039555
Other languages
French (fr)
Other versions
WO2003054152A2 (en
Inventor
Y Tom Tang
Vinod Asundi
Ryle W Goodrich
Feiyan Ren
Jie Zhang
Qing A Zhao
Jian-Rui Wang
Malabika Ghosh
Aidong J Xue
Tom Wehrman
Gezhi Weng
Ping Zhou
Radoje T Drmanac
Zhiwei Wang
Yunqing Ma
Dunrui Wang
Rui-Hong Chen
Chongjun Xu
Bryan J Boyle
Original Assignee
Nuvelo Inc
Y Tom Tang
Vinod Asundi
Ryle W Goodrich
Feiyan Ren
Jie Zhang
Qing A Zhao
Jian-Rui Wang
Malabika Ghosh
Aidong J Xue
Tom Wehrman
Gezhi Weng
Ping Zhou
Radoje T Drmanac
Zhiwei Wang
Yunqing Ma
Dunrui Wang
Rui-Hong Chen
Chongjun Xu
Bryan J Boyle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/128,558 external-priority patent/US20040219521A1/en
Application filed by Nuvelo Inc, Y Tom Tang, Vinod Asundi, Ryle W Goodrich, Feiyan Ren, Jie Zhang, Qing A Zhao, Jian-Rui Wang, Malabika Ghosh, Aidong J Xue, Tom Wehrman, Gezhi Weng, Ping Zhou, Radoje T Drmanac, Zhiwei Wang, Yunqing Ma, Dunrui Wang, Rui-Hong Chen, Chongjun Xu, Bryan J Boyle filed Critical Nuvelo Inc
Priority to CA002469941A priority Critical patent/CA2469941A1/en
Priority to EP02805571A priority patent/EP1504099A4/en
Priority to AU2002366951A priority patent/AU2002366951A1/en
Publication of WO2003054152A2 publication Critical patent/WO2003054152A2/en
Publication of WO2003054152A3 publication Critical patent/WO2003054152A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
PCT/US2002/039555 2001-12-10 2002-12-10 Novel nucleic acids and polypeptides WO2003054152A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002469941A CA2469941A1 (en) 2001-12-10 2002-12-10 Novel nucleic acids and polypeptides
EP02805571A EP1504099A4 (en) 2001-12-10 2002-12-10 Novel nucleic acids and polypeptides
AU2002366951A AU2002366951A1 (en) 2001-12-10 2002-12-10 Novel nucleic acids and polypeptides

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US33973901P 2001-12-10 2001-12-10
US60/339,739 2001-12-10
US33945301P 2001-12-11 2001-12-11
US60/339,453 2001-12-11
US36509102P 2002-03-14 2002-03-14
US36538402P 2002-03-14 2002-03-14
US60/365,384 2002-03-14
US60/365,091 2002-03-14
US37261502P 2002-04-12 2002-04-12
US37238102P 2002-04-12 2002-04-12
US60/372,615 2002-04-12
US60/372,381 2002-04-12
US10/128,558 US20040219521A1 (en) 2000-01-21 2002-04-22 Novel nucleic acids and polypeptides
US10/128,558 2002-04-22
US37604502P 2002-04-24 2002-04-24
US60/376,045 2002-04-24

Publications (2)

Publication Number Publication Date
WO2003054152A2 WO2003054152A2 (en) 2003-07-03
WO2003054152A3 true WO2003054152A3 (en) 2004-12-16

Family

ID=27574889

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/039555 WO2003054152A2 (en) 2001-12-10 2002-12-10 Novel nucleic acids and polypeptides

Country Status (4)

Country Link
EP (1) EP1504099A4 (en)
AU (1) AU2002366951A1 (en)
CA (1) CA2469941A1 (en)
WO (1) WO2003054152A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932821B2 (en) 2003-03-19 2015-01-13 Biogen Idec Ma Inc. NOGO receptor binding protein
US9394330B2 (en) 2012-03-21 2016-07-19 Alios Biopharma, Inc. Solid forms of a thiophosphoramidate nucleotide prodrug
US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9315698U1 (en) * 1993-10-14 1993-12-23 BÜCHI LABORATORIUMS-TECHNIK AG, Flawil Evaporator flask for a rotary evaporator
AU2002250143A1 (en) * 2001-03-16 2002-10-03 Eli Lilly And Company Lp mammalian proteins; related reagents
KR100607612B1 (en) 2001-06-20 2006-08-02 제넨테크, 인크. Compositions and Methods for the Diagnosis and Treatment of Tumor
US20030068691A1 (en) * 2001-07-16 2003-04-10 Applera Corporation Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
EP1427747B1 (en) * 2001-08-30 2012-04-11 ARCA biopharma, Inc. Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
JP2005523681A (en) 2001-10-04 2005-08-11 イミュネックス・コーポレーション UL16 binding protein 4
AU2003226131A1 (en) 2002-03-28 2003-10-13 Bristol-Myers Squibb Company Novel human cell surface protein with immunoglobulin folds, bgs-19
WO2003091436A1 (en) 2002-04-26 2003-11-06 Fujisawa Pharmaceutical Co., Ltd. Novel 35 kd protein
WO2004005335A2 (en) * 2002-07-05 2004-01-15 Borean Pharma A/S Multimerised growth hormone fusion proteins
AU2003270439B2 (en) 2002-09-11 2009-09-24 Genentech, Inc. Novel composition and methods for the treatment of immune related diseases
AU2003260966A1 (en) * 2002-09-30 2004-04-23 Japan As Represented By The President Of The University Of Tokyo Genes and polypeptides relating to human pancreatic cancers
AU2004276646B2 (en) 2003-09-29 2012-07-12 Chugai Seiyaku Kabushiki Kaisha Protein expressed in NK cell
WO2005056791A1 (en) * 2003-10-30 2005-06-23 Kazusa Dna Research Institute Foundation Novel plexin polypeptide, dna encoding the same and use thereof
EP3434275A1 (en) 2003-11-06 2019-01-30 Seattle Genetics, Inc. Assay for cancer cells based on the use of auristatin conjugates with antibodies
BRPI0507168A (en) * 2004-01-27 2007-06-26 Nuvelo Inc gastrointestinal proliferative factor and its applications
GB0403491D0 (en) * 2004-02-17 2004-03-24 Univ Cambridge Tech Polypeptides, methods and means
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
US7901881B2 (en) 2004-04-09 2011-03-08 The United States Of America As Represented By The Department Of Health And Human Services Diagnostic tool for diagnosing benign versus malignant thyroid lesions
CN102973947A (en) 2004-06-01 2013-03-20 健泰科生物技术公司 Antibody-drug conjugates and methods
PT1776136E (en) 2004-06-24 2012-12-05 Biogen Idec Inc Treatment of conditions involving demyelination
WO2006008294A2 (en) * 2004-07-23 2006-01-26 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of slim3 for neurodegenerative diseases
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
AU2005286607B2 (en) 2004-09-23 2011-01-27 Genentech, Inc. Cysteine engineered antibodies and conjugates
ES2772674T3 (en) 2005-05-12 2020-07-08 Zymogenetics Inc Compositions and methods for modulating immune responses
CA2614421A1 (en) 2005-07-08 2007-01-18 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
WO2007030930A1 (en) 2005-09-13 2007-03-22 National Research Council Of Canada Methods and compositions for modulating tumor cell activity
GB0522113D0 (en) * 2005-10-28 2005-12-07 Ares Trading Sa vWFA-domain containing proteins
GB0525999D0 (en) * 2005-12-21 2006-02-01 Ares Trading Sa Novel members of the kazal family of serine protease inhibitors
GB0615287D0 (en) * 2006-08-01 2006-09-06 Ares Trading Sa Integral membrane protein
AU2007324111A1 (en) * 2006-10-02 2008-05-29 The Scripps Research Institute An enzyme regulating ether lipid signaling pathways
GB0620735D0 (en) * 2006-10-18 2006-11-29 Ares Trading Sa Proteins
PL2173379T3 (en) 2007-07-02 2016-02-29 Oncomed Pharm Inc Compositions and methods for treating and diagnosing cancer
GB0805159D0 (en) 2008-03-19 2008-04-23 Sancho Madrid David Immune modulation via C-type lectin
AU2008294074B2 (en) * 2007-08-30 2015-01-22 Walter And Eliza Hall Institute Of Medical Research Dendritic cell marker and uses thereof
CN102099055A (en) * 2007-10-04 2011-06-15 津莫吉尼蒂克斯公司 B7 family member zb7h6 and related compositions and methods
JP5754046B2 (en) * 2007-11-08 2015-07-22 バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. Use of a LINGO-4 antagonist in the treatment of conditions involving demyelination
CA2719189C (en) 2008-04-09 2020-08-04 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
US20110110861A1 (en) * 2008-05-13 2011-05-12 Mireille Hanna Lahoud Methods of Detecting Cells with a Disrupted Cell Membrane, Cells Infected with A Pathogen, Dying Cells or Dead Cells
CA2997870A1 (en) 2008-07-09 2010-01-14 Biogen Ma Inc. Compositions comprising antibodies to lingo or fragments thereof
US8227417B2 (en) 2008-07-25 2012-07-24 The United States Of America As Represented By The Secretary, Department Of Health And Human Services HMGN polypeptides as immune enhancers and HMGN antagonists as immune suppressants
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
EP3061808B1 (en) 2009-02-03 2020-08-12 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
AU2010268690B2 (en) 2009-07-03 2011-11-10 Avipep Pty Ltd Immuno-conjugates and methods for producing them
WO2011004404A1 (en) * 2009-07-10 2011-01-13 Decode Genetics Ehf Genetic variants for predicting risk of glaucoma
CA2809819A1 (en) 2009-09-09 2011-03-17 Centrose, Llc Extracellular targeted drug conjugates
AU2010324506B2 (en) 2009-11-24 2015-02-26 Alethia Biotherapeutics Inc. Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume
WO2011075786A1 (en) 2009-12-23 2011-06-30 Avipep Pty Ltd Immuno-conjugates and methods for producing them 2
ES2430567T3 (en) 2010-04-15 2013-11-21 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
SG185428A1 (en) 2010-06-08 2012-12-28 Genentech Inc Cysteine engineered antibodies and conjugates
EP2619216A4 (en) 2010-09-22 2014-04-02 Alios Biopharma Inc Substituted nucleotide analogs
ES2544608T3 (en) 2010-11-17 2015-09-02 Genentech, Inc. Antibody and alaninyl-maitansinol conjugates
CA2833404A1 (en) 2011-04-21 2012-10-26 Garvan Institute Of Medical Research Modified variable domain molecules and methods for producing and using them b
RU2638806C2 (en) 2011-05-12 2017-12-15 Дженентек, Инк. Lc-ms/ms method for multiple reactions monitoring to identify therapeutic antibodies in animal species using framework signature peptides
WO2013012747A1 (en) 2011-07-15 2013-01-24 Oncomed Pharmaceuticals, Inc. Rspo binding agents and uses thereof
WO2013055987A1 (en) 2011-10-14 2013-04-18 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
NZ626742A (en) 2012-02-22 2016-06-24 Alethia Biotherapeutics Inc Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
EA030716B1 (en) 2012-05-14 2018-09-28 Байоджен Ма Инк. Lingo-2 antagonists for treatment of conditions involving motor neurons
CA2878868A1 (en) 2012-07-13 2014-01-16 Austin L. Gurney Rspo3 binding agents and uses thereof
AU2013328619B2 (en) 2012-10-12 2016-11-17 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-PSMA antibody conjugates
PL2839860T3 (en) 2012-10-12 2019-10-31 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP2906250B1 (en) 2012-10-12 2018-05-30 ADC Therapeutics SA Pyrrolobenzodiazepine-anti-psma antibody conjugates
MX364327B (en) 2012-10-12 2019-04-23 Medimmune Ltd Pyrrolobenzodiazepine-anti-cd22 antibody conjugates.
CA2887895C (en) 2012-10-12 2019-10-29 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd19 antibody conjugates
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
RS57104B1 (en) 2012-10-12 2018-06-29 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
US9821074B2 (en) 2013-03-13 2017-11-21 Genentech, Inc. Pyrrolobenzodiazepines and conjugates thereof
CA2905181C (en) 2013-03-13 2020-06-02 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy
CN105142674B (en) 2013-03-13 2018-11-13 麦迪穆有限责任公司 Pyrrolobenzodiazepines Zhuo and its conjugate
EP3789036A1 (en) 2013-07-16 2021-03-10 F. Hoffmann-La Roche AG Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
CN105636612B (en) 2013-08-12 2020-01-14 基因泰克公司 Antibody-drug conjugates and methods of use and treatment
EP3054986B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
MX371092B (en) 2013-12-16 2020-01-16 Genentech Inc Peptidomimetic compounds and antibody-drug conjugates thereof.
BR112016013258A2 (en) 2013-12-16 2018-01-16 Genentech Inc antibody-drug conjugate, pharmaceutical composition, method for treating cancer and kit
PE20161394A1 (en) 2013-12-16 2017-01-06 Genentech Inc PEPTIDOMIMETIC COMPOUNDS AND THEIR ANTIBODY-DRUG CONJUGATES
JP6531166B2 (en) 2014-09-10 2019-06-12 メドイミューン・リミテッドMedImmune Limited Pyrrolobenzodiazepine and its conjugate
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
BR112017003236A2 (en) 2014-09-12 2017-11-28 Genentech Inc cysteine engineered antibodies, drug conjugates and antibodies, drug and antibody conjugate preparation method and pharmaceutical composition
WO2016040825A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
WO2016044295A1 (en) 2014-09-16 2016-03-24 Oncomed Pharmaceuticals, Inc. Treatment of fibrotic diseases
BR112017005393A2 (en) 2014-09-17 2017-12-05 Genentech Inc compound of formula I, method of preparing a conjugate of formula a, conjugate of formula a1, composition comprising a mixture of antibody-drug conjugate compounds, pharmaceutical composition, and use of a conjugate or composition
KR20170101895A (en) 2014-11-25 2017-09-06 에이디씨 테라퓨틱스 에스에이 Pyrrolobenzodiazepine-antibody conjugates
WO2016090050A1 (en) 2014-12-03 2016-06-09 Genentech, Inc. Quaternary amine compounds and antibody-drug conjugates thereof
WO2016112270A1 (en) 2015-01-08 2016-07-14 Biogen Ma Inc. Lingo-1 antagonists and uses for treatment of demyelinating disorders
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
AU2016325610B2 (en) 2015-09-25 2019-10-10 Genentech, Inc. Anti-TIGIT antibodies and methods of use
MA43345A (en) 2015-10-02 2018-08-08 Hoffmann La Roche PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
MA43354A (en) 2015-10-16 2018-08-22 Genentech Inc CONJUGATE DRUG CONJUGATES WITH CLOUDY DISULPHIDE
MA45326A (en) 2015-10-20 2018-08-29 Genentech Inc CALICHEAMICIN-ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
US20170315132A1 (en) 2016-03-25 2017-11-02 Genentech, Inc. Multiplexed total antibody and antibody-conjugated drug quantification assay
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN118436801A (en) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 PROTAC antibody conjugates and methods of use thereof
WO2017205741A1 (en) 2016-05-27 2017-11-30 Genentech, Inc. Bioanalytical method for the characterization of site-specific antibody-drug conjugates
US10639378B2 (en) 2016-06-06 2020-05-05 Genentech, Inc. Silvestrol antibody-drug conjugates and methods of use
WO2018031662A1 (en) 2016-08-11 2018-02-15 Genentech, Inc. Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
JP7050770B2 (en) 2016-10-05 2022-04-08 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Method for preparing antibody drug conjugate
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
JP2020502218A (en) 2016-12-21 2020-01-23 メレオ バイオファーマ 3 リミテッド Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
WO2018146189A1 (en) 2017-02-08 2018-08-16 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
RS63502B1 (en) 2017-04-18 2022-09-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
EP3612234B1 (en) 2017-04-20 2024-03-13 ADC Therapeutics SA Combination therapy with an anti-axl antibody-drug conjugate
JP7145891B2 (en) 2017-06-14 2022-10-03 アーデーセー セラピューティクス ソシエテ アノニム Dosing Regimens for Administering Anti-CD19 ADCs
HRP20220311T1 (en) 2017-08-18 2022-05-13 Medimmune Limited Pyrrolobenzodiazepine conjugates
WO2019060398A1 (en) 2017-09-20 2019-03-28 Ph Pharma Co., Ltd. Thailanstatin analogs
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
WO2019178364A2 (en) * 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
AU2019324170A1 (en) 2018-08-23 2021-02-18 Seagen, Inc. Anti-TIGIT antibodies
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
CA3115110A1 (en) 2018-10-24 2020-04-30 F. Hoffmann-La Roche Ag Conjugated chemical inducers of degradation and methods of use
JP2022513198A (en) 2018-12-10 2022-02-07 ジェネンテック, インコーポレイテッド Photocrosslinkable peptide for site-specific conjugation to Fc-containing proteins
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
GB202211117D0 (en) * 2022-07-29 2022-09-14 Replay Holdings Llc Compositions and methods for non-immunogenecity
WO2024138128A2 (en) 2022-12-23 2024-06-27 Genentech, Inc. Cereblon degrader conjugates, and uses thereof
WO2024220546A2 (en) 2023-04-17 2024-10-24 Peak Bio, Inc. Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP1504099A4 *
VOLLRATH D. ET AL: "The human Y chromosome: a 43-interval map based on naturally occurring deletions", SCIENCE, vol. 258, October 1992 (1992-10-01), pages 52 - 59, XP002940166 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932821B2 (en) 2003-03-19 2015-01-13 Biogen Idec Ma Inc. NOGO receptor binding protein
US9394330B2 (en) 2012-03-21 2016-07-19 Alios Biopharma, Inc. Solid forms of a thiophosphoramidate nucleotide prodrug
US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

Also Published As

Publication number Publication date
CA2469941A1 (en) 2003-07-03
EP1504099A2 (en) 2005-02-09
WO2003054152A2 (en) 2003-07-03
EP1504099A4 (en) 2006-05-10
AU2002366951A1 (en) 2003-07-09

Similar Documents

Publication Publication Date Title
WO2003054152A3 (en) Novel nucleic acids and polypeptides
WO2003025148A3 (en) Novel nucleic acids and polypeptides
WO2002070539A3 (en) Novel nucleic acids and polypeptides
WO2003023013A3 (en) Novel nucleic acids and polypeptides
WO2002081731A3 (en) Novel nucleic acids and polypeptides
WO2001075067A3 (en) Novel nucleic acids and polypeptides
WO2001057188A3 (en) Novel nucleic acids and polypeptides
WO2001057190A3 (en) Novel nucleic acids and polypeptides
WO2002022660A3 (en) Novel nucleic acids and polypeptides
WO2001066689A3 (en) Novel nucleic acids and polypeptides
WO2002031111A3 (en) Novel nucleic acids and polypeptides
WO2001088088A3 (en) Novel nucleic acids and polypeptides
WO2004009834A3 (en) Novel nucleic acids and secreted polypeptides
WO2002059260A3 (en) Nucleic acids and polypeptides
WO2001053312A8 (en) Novel nucleic acids and polypeptides
WO2001053455A3 (en) Novel nucleic acids and polypeptides
WO2004080148A3 (en) Novel nucleic acids and polypeptides
WO2003029271A3 (en) Novel nucleic acids and polypeptides
WO2004087874A3 (en) Novel nucleic acids and polypeptides
WO2002018424A3 (en) Nucleic acids and polypeptides
WO2001079449A3 (en) Novel nucleic acids and polypeptides
WO2003080795A3 (en) Novel nucleic acids and secreted polypeptides
WO2005049806A3 (en) Novel nucleic acids and polypeptides
WO2002081517A3 (en) Novel polypeptides and nucleic acids encoded thereby
WO2001075068A3 (en) Secreted proteins and polynucleotides encoding them

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2002805571

Country of ref document: EP

Ref document number: 2469941

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002366951

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2002805571

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2002805571

Country of ref document: EP