WO2003033678A3 - Methods of using deacetylase inhibitors to promote cell differentiation and regeneration - Google Patents

Methods of using deacetylase inhibitors to promote cell differentiation and regeneration Download PDF

Info

Publication number
WO2003033678A3
WO2003033678A3 PCT/US2002/033570 US0233570W WO03033678A3 WO 2003033678 A3 WO2003033678 A3 WO 2003033678A3 US 0233570 W US0233570 W US 0233570W WO 03033678 A3 WO03033678 A3 WO 03033678A3
Authority
WO
WIPO (PCT)
Prior art keywords
progenitor cell
cell differentiation
cell
enhancing
regeneration
Prior art date
Application number
PCT/US2002/033570
Other languages
French (fr)
Other versions
WO2003033678A2 (en
Inventor
Vittorio Sartorelli
Pier Lorenzo Puri
Original Assignee
Us Gov Health & Human Serv
Salk Inst For Biological Studi
Vittorio Sartorelli
Pier Lorenzo Puri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Salk Inst For Biological Studi, Vittorio Sartorelli, Pier Lorenzo Puri filed Critical Us Gov Health & Human Serv
Priority to AU2002348474A priority Critical patent/AU2002348474A1/en
Priority to US10/492,901 priority patent/US7229963B2/en
Publication of WO2003033678A2 publication Critical patent/WO2003033678A2/en
Publication of WO2003033678A3 publication Critical patent/WO2003033678A3/en
Priority to US11/800,151 priority patent/US7795208B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A method of enhancing progenitor cell differentiation, including enhancing myogenesis, neurogenesis, and hematopoiesis, by contacting a progenitor cell with an effective amount of a deacetylase inhibitor (DI). The progenitor cell can be part of cell culture, such as a cell culture used for in vitro or in vivo analysis of progenitor cell differentiation, or can be part of an organsism, such as a human or other mammal. Contacting the progenitor cell with a DI can lead to enhancement of expression of terminal cell-type specific genes in the progenitor cell, such as enhancing expression of muscle-specific genes in myoblasts. Administering a DI to a subject also can provide some prophylactic or therapeutic effect for inhibiting, preventing, or treating associated with a degeneration or loss of tissue. The DI can be administered to a subject as part of a pharmaceutical composition.
PCT/US2002/033570 2001-10-18 2002-10-17 Methods of using deacetylase inhibitors to promote cell differentiation and regeneration WO2003033678A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002348474A AU2002348474A1 (en) 2001-10-18 2002-10-17 Methods of using deacetylase inhibitors to promote cell differentiation and regeneration
US10/492,901 US7229963B2 (en) 2001-10-18 2002-10-17 Methods of using deacetylase inhibitors to promote cell differentiation and regeneration
US11/800,151 US7795208B2 (en) 2001-10-18 2007-05-04 Methods of using deacetylase inhibitors to promote cell differentiation and regeneration

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33570501P 2001-10-18 2001-10-18
US60/335,705 2001-10-18
US34385401P 2001-10-25 2001-10-25
US60/343,854 2001-10-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10492901 A-371-Of-International 2002-10-17
US11/800,151 Continuation US7795208B2 (en) 2001-10-18 2007-05-04 Methods of using deacetylase inhibitors to promote cell differentiation and regeneration

Publications (2)

Publication Number Publication Date
WO2003033678A2 WO2003033678A2 (en) 2003-04-24
WO2003033678A3 true WO2003033678A3 (en) 2003-10-16

Family

ID=26989849

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033570 WO2003033678A2 (en) 2001-10-18 2002-10-17 Methods of using deacetylase inhibitors to promote cell differentiation and regeneration

Country Status (3)

Country Link
US (2) US7229963B2 (en)
AU (1) AU2002348474A1 (en)
WO (1) WO2003033678A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732475B2 (en) 2005-07-14 2010-06-08 Takeda San Diego, Inc. Histone deacetylase inhibitors

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002348474A1 (en) * 2001-10-18 2003-04-28 The Salk Institute For Biological Studies Methods of using deacetylase inhibitors to promote cell differentiation and regeneration
US20070207950A1 (en) * 2005-12-21 2007-09-06 Duke University Methods and compositions for regulating HDAC6 activity
US7737175B2 (en) 2007-06-01 2010-06-15 Duke University Methods and compositions for regulating HDAC4 activity
WO2009073618A2 (en) * 2007-11-30 2009-06-11 New York Medical College Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure
WO2009073594A1 (en) 2007-11-30 2009-06-11 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
US8512696B2 (en) 2007-11-30 2013-08-20 Autologous, Llc Methods of isolating non-senescent cardiac stem cells and uses thereof
AU2008334058B2 (en) 2007-11-30 2014-07-10 New York Medical College Compositions comprising vascular and myocyte progenitor cells and methods of their use
JP6025732B2 (en) 2010-10-13 2016-11-16 テトラロジック シェイプ ユーケイ エルティーディー Pharmaceutical formulations for histone deacetylase inhibitors
US20130309209A1 (en) * 2010-10-22 2013-11-21 Center For Regenerative Medicine Of Barcelona Formation of hematopoietic progenitor cells from mesenchymal stem cells
WO2013114413A1 (en) 2012-02-03 2013-08-08 Italfarmaco S.P.A. Diethyl- [6- (4-hydroxycarbamoyl-phenyl-carbamoyloxy-methyl) - naphthalen-2-yl-methyl] -ammonium chloride for use in the treatment of muscular dystrophy
KR101620482B1 (en) 2013-07-29 2016-05-12 한국생명공학연구원 Pharmaceutical composition for preventing or treating muscle weakness diseases comprising Protirelin
KR101496610B1 (en) * 2014-03-04 2015-02-25 서울대학교산학협력단 A Composition for Inducing Myogenic-lineage Differentiation of Stem Cells
FR3025105B1 (en) * 2014-09-02 2018-03-02 Centre Hospitalier Universitaire Pontchaillou USE OF VALPROIC ACID OR ITS DERIVATIVES IN THE TREATMENT OF HEPCIDINE FAILURES AND THEIR CONSEQUENCES
BR112021020547A2 (en) 2019-05-21 2021-12-14 Nestle Sa Dietary Butyrate

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443470A (en) 1981-09-03 1984-04-17 International Minerals & Chemical Corp. Method of promoting growth and enhancing feed efficiency in meat producing animals
US4822821A (en) 1986-10-10 1989-04-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
US5025029A (en) 1986-10-10 1991-06-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
FR2633929B2 (en) 1987-09-25 1995-05-24 Picardie Universite NON-TOXIC N-BUTYRIC ACID DERIVATIVES WITH DELAYED THERAPEUTIC ACTIONS
EP0424055B1 (en) 1989-10-17 1994-12-07 Unilever Plc Feedstuffs
JPH0775593A (en) 1993-09-08 1995-03-20 Suntory Ltd Production of protein
US5563173A (en) 1994-12-22 1996-10-08 Research Development Foundation Anti-proliferative effects of sodium butyrate
DE69637669D1 (en) 1995-06-06 2008-10-16 Osiris Therapeutics Inc MYOGENE DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS
US6110697A (en) 1995-09-20 2000-08-29 Merck & Co., Inc. Histone deacetylase as target for antiprotozoal agents
EP0827742A1 (en) 1996-09-04 1998-03-11 Vrije Universiteit Brussel Use of histone deacetylase inhibitors for treating fribosis or cirrhosis
US6030961A (en) 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof
US6043389A (en) 1997-03-11 2000-03-28 Mor Research Applications, Ltd. Hydroxy and ether-containing oxyalkylene esters and uses thereof
AU1395999A (en) 1997-11-10 1999-05-31 Salk Institute For Biological Studies, The Methods for the use of inhibitors of co-repressors for the treatment of neoplastic diseases
US6262116B1 (en) 1998-01-23 2001-07-17 Sloan-Kettering Institute For Cancer Research Transcription therapy for cancers
AUPP495598A0 (en) * 1998-07-30 1998-08-20 Walter And Eliza Hall Institute Of Medical Research, The A novel regulatory molecule and genetic sequences encoding same
AUPP505798A0 (en) * 1998-08-04 1998-08-27 Fujisawa Pharmaceutical Co., Ltd. Novel compound fr225497 substance
CA2383999A1 (en) 1999-09-08 2001-03-15 Sloan-Kettering Institute For Cancer Research Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
WO2002060430A1 (en) * 2001-02-01 2002-08-08 Cornell Research Foundation, Inc. Use of retinoids plus histone deacetylase inhibitors to inhibit the growth of solid tumors
AU2002348474A1 (en) * 2001-10-18 2003-04-28 The Salk Institute For Biological Studies Methods of using deacetylase inhibitors to promote cell differentiation and regeneration

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DAVIS T. ET AL.: "Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells", CLINICAL CANCER RESEARCH, vol. 6, no. 11, November 2000 (2000-11-01), pages 4334 - 4342, XP002965439 *
GABBIANELLI M. ET AL.: "Hemoglobin switching in unicellular erythroid culture of sibling erythroid burst-forming units: kit ligand induces a dose-dependent fetal hemoglobin reactivation potential by sodium butyrate", BLOOD, vol. 95, no. 11, 1 June 2000 (2000-06-01), pages 3555 - 3561, XP002965441 *
O'NEILL L.P. ET AL.: "A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation", EMBO JOURNAL, vol. 18, no. 10, 1999, pages 2897 - 2907, XP002965442 *
SCHULTZ R.M. ET AL.: "Reprogramming of gene expression during preimplantation development", JOURNAL OF EXPERIMENTAL ZOOLOGY, vol. 285, no. 3, 15 October 1999 (1999-10-15), pages 276 - 282, XP002965443 *
STEINBACH O. ET AL.: "Histone deacetylase activity is required for the induction of the MyoD muscle cell lineage in xenopus", BIOLOGICAL CHEMISTRY, vol. 381, no. 9/10, September 2000 (2000-09-01) - October 2000 (2000-10-01), pages 1013 - 1016, XP002965440 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732475B2 (en) 2005-07-14 2010-06-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7741494B2 (en) 2005-07-14 2010-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors

Also Published As

Publication number Publication date
AU2002348474A1 (en) 2003-04-28
US20050054091A1 (en) 2005-03-10
US7229963B2 (en) 2007-06-12
US7795208B2 (en) 2010-09-14
US20080248994A1 (en) 2008-10-09
WO2003033678A2 (en) 2003-04-24

Similar Documents

Publication Publication Date Title
WO2003033678A3 (en) Methods of using deacetylase inhibitors to promote cell differentiation and regeneration
Novak et al. Macrophage activation and skeletal muscle healing following traumatic injury
EP2305276A3 (en) Processed lipoaspirate cells for use in therapy
EA200600076A1 (en) COMPOSITIONS AND METHODS OF INCREASING THE ACTIVITY OF TELOMERASE
WO2005013885A3 (en) Pharmaceutical compositions and methods for accelerating wound healing
WO2006127007A3 (en) Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
WO2007120883A3 (en) Compositions and their uses directed to hepcidin
BRPI0414455A (en) Methods for Using Regenerative Cells to Treat Peripheral Vascular Disease and Related Disorders
You et al. Comparative analysis of periprostatic implantation and intracavernosal injection of human adipose tissue‐derived stem cells for erectile function recovery in a rat model of cavernous nerve injury
EP2422799A3 (en) Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
RU2009138327A (en) COMPOSITIONS AND METHODS OF DIRECTED ELIMINATION OF MUTATIONAL USE IN DIRECTED CARE THERAPY
GEP20022804B (en) Erythropoietin Derivatives
ATE374251T1 (en) COMPOSITIONS FOR GENE THERAPY OF DIABETES
HK1071687A1 (en) Pharmaceutical preparation and method of treatmentof human malignancies with arginine deprivation
BRPI0810336A2 (en) "method for treating and / or preventing skin ulcers in an individual"
Hu et al. Combination of mesenchymal stem cell-conditioned medium and botulinum toxin type A for treating human hypertrophic scars
ATE277628T1 (en) TREATMENT OF HEMATOPOIETIC CELLS WITH CXCR4 AGONISTS
Al-Shaibani et al. Cellular therapy for wounds: applications of mesenchymal stem cells in wound healing
WO2004108088A3 (en) Methods and compositions for interferon therapy
Rasouli et al. The role of oxygen tension in cell fate and regenerative medicine: implications of hypoxia/hyperoxia and free radicals
EP1519755A4 (en) Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostic or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derived therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue
WO2005054446A3 (en) Use of polysulphated alginate in cellular matrices
WO2004071443A3 (en) Methods and compositions for modulating stem cells
WO2005028616A3 (en) Morphogen compositions and methods of use thereof to treat heart disorders
WO2022140428A3 (en) Inhibitors of peptidylarginine deiminases

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 10492901

Country of ref document: US

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP