WO2002041862A1 - An oral hygiene preparation for inhibiting halitosis - Google Patents
An oral hygiene preparation for inhibiting halitosis Download PDFInfo
- Publication number
- WO2002041862A1 WO2002041862A1 PCT/NO2001/000458 NO0100458W WO0241862A1 WO 2002041862 A1 WO2002041862 A1 WO 2002041862A1 NO 0100458 W NO0100458 W NO 0100458W WO 0241862 A1 WO0241862 A1 WO 0241862A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oral hygiene
- copper
- gluconate
- tablet
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- This invention relates to an oral hygiene preparation for inhibiting halitosis, in the form of a tablet or a powder which upon dissolution in water forms a mouthwash.
- the mouthwash thus produced is effective against oral malodour.
- oral malodour is caused by volatile sulfur compounds (VSC) produced by bacterial catabolization of proteins in the oral cavity, in particular in the crypts at the back of the tongue and in periodontal pockets.
- VSC volatile sulfur compounds
- the VSC are mainly hydrogen sulfide and methyl mercaptan, which have a very unpleasant odour, even in low concentrations.
- the VSC are also known to be able to penetrate oral epithelium and damage cells in the underlying connective tissue and bone, a process which is believed to be an important aspect of the initiation and progression of periodontal disease.
- water-soluble salts of certain metals can inhibit oral malodour.
- metals such as divalent cations of zinc, copper and tin.
- the metals mentioned above have high affinity for sulfur and eliminate the VSC by forming insoluble sulfides with precursors of the volatile sulfur compounds, a reaction which inhibits further formation of the odiferous gases in the oral cavity.
- water soluble, cationic, antibacterial agents such as the bis-biguanides and the quaternary ammonium compounds are able to inhibit oral malodour when used as mouth rinses.
- Japanese Patent Application JP 1996/356310 discloses a composition for oral cavity, which can be used for prevention of bad breath. Possible components of the composition are triclosan, sodium bicarbonate, menthol and other fragrances.
- Japanese Patent Application JP 1988/317621 (Publication JP 90164816 A2) relates to an aqueous drink containing ferrous sulfate and sodium bicarbonate. It is stated in the application that halitosis is inhibited by drinking said drink.
- Japanese Patent Application JP 1985/39538 (Publication JP 86197510 A2) relates to a composition which may be in the form of a toothpaste, tooth powder, mouthwash, gingiva massage cream or local liquid or a paste paint.
- the composition contains small amounts of nitroimidazole.
- the composition further contains extracts from leaves of camellia plant such as tea tree or camellia or sodium copper-chlorophyllin.
- the composition is used for prevention of periodental diseases and stomatosis and may also inhibit gram negative, anaerobic microorgansims from forming volatile sulfur compounds in the oral cavity.
- WO 99/56714 relates to a bactericide for detergents which comprises an inorganic support having antifungal metal ions supported thereon, and a denture detergent containing the bactericide.
- the bactericide is specifically intended for dentures and it is stated that it suppresses bad breath and denture-specific stomatitis.
- WO-0023040 relates to a dry composition for inhibiting oral malodour, which comprises: a) at least one carrier material selected from saccharide materials
- sweeteners b) at least one processing aid selected from oleaginous substances; and c) at least one active ingredient selected among many different types, including metallic ions.
- Copper gluconate is mentioned as a source of metallic ions. It has now been discovered that a mouthwash produced from a tablet or a powder, which can be rapidly solubilized in water and which contains divalent cations of copper, exhibits a marked inhibiting effect against oral malodour.
- the present invention provides an oral hygiene preparation for inhibiting halitosis, in the form of a tablet or powder which upon dissolution in water forms a mouthwash.
- the preparation contains copper(ll)gluconate which provides cupric ions in water, and a physiologically acceptable disintegrating agent selected from sodium and calcium bicarbonate. Copper(ll)gluconate has sufficient solubility so that all of it is dissolved when the composition is added to a suitable amount of water.
- Copper(ll)gluconate contains about 15% of copper.
- a suitable amount of copper in a tablet or a powder dosage is an amount which provides a copper concentration of 0.003% to 0,3% by weight in 10 ml of water, and preferably a concentration of about 0,015%.
- a tablet or a powder dosage should contain copper(ll)gluconate in an amount of 0.3-30 mg, preferably 0,5-5 mg, calculated as free cupric ions. This corresponds to 2-200 mg, preferably 3,5-35 mg, of copper gluconate.
- the preparation according to the invention contains a physiologically acceptable disintegrating agent which facilitates the rapid solubilisation of the preparation, including the copper(ll)gluconate.
- the disintegrating agents are selected from sodium and calcium bicarbonate, which may be used in amounts of 20-2000 mg, in particular 50-500 mg in a tablet designed to be dissolved in 10 ml of water. In a powder the amount of disintegrating agent, such as sodium bicarbonate, will generally be less than in a tablet.
- a particularly preferred preparation according to the invention is a tablet which contains 50-500 mg of sodium bicarbonate and 5-50 mg of copper(ll) gluconate.
- composition of the invention may also contain further components such as sweetening agents, flavouring agents, excipients and fillers.
- sweetening agents such as aspartam, saccharin, xylitol and sorbitol.
- other components such as acesulfam K, aspartam, saccharin, xylitol and sorbitol.
- Tablets in the form of lozenges containing copper are already on the market as dietary supplements or for inhibiting oral malodour. Such tablets are designed to be solubilized in the mouth by sucking and are then often only sparingly soluble in water. Such tablets are markedly different from the tablets described in the present application.
- An agent with an inhibiting effect on oral malodour is far more effective in the aqueous form of a mouthwash than in the dry state of a sucking tablet. The reason is that the VSC are highly soluble in water.
- the aqueous part of a mouthwash is accordingly effective as such, this being in addition to the effect of the solubilized agents present in the mouthwash, as mentioned above.
- the present invention combines the availability and convenience in the use of tablets, powders or other solid compositions, with the superior effect exhibited by mouthwashes.
- a further advantage of a mouthwash compared with a sucking tablet is that the use of a mouthwash involves a local effect only of the copper cations in the mouth, because the mouthwash is expectorated after use, whereas the ingredients in a sucking tablet would have to be swallowed.
- a powder designed to be dissolved in 20 ml of water A powder designed to be dissolved in 20 ml of water:
- Sweeteners and flavours quantum satisfies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002224224A AU2002224224A1 (en) | 2000-11-21 | 2001-11-19 | An oral hygiene preparation for inhibiting halitosis |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO20005877A NO20005877A (en) | 2000-11-21 | 2000-11-21 | Oral hygiene product for the inhibition of halitosis |
NO20005877 | 2000-11-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002041862A1 true WO2002041862A1 (en) | 2002-05-30 |
Family
ID=19911823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NO2001/000458 WO2002041862A1 (en) | 2000-11-21 | 2001-11-19 | An oral hygiene preparation for inhibiting halitosis |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2002224224A1 (en) |
NO (1) | NO20005877A (en) |
WO (1) | WO2002041862A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3003247A4 (en) * | 2013-03-15 | 2017-01-04 | CDA Research Group, Inc. | Topical copper ion treatments |
US10398733B2 (en) | 2013-03-15 | 2019-09-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body |
US10813948B2 (en) | 2013-03-15 | 2020-10-27 | Cda Research Group, Inc. | Methods of treatment using topical copper ion formulations |
US11000545B2 (en) | 2013-03-15 | 2021-05-11 | Cda Research Group, Inc. | Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza |
US11193184B2 (en) | 2019-02-22 | 2021-12-07 | Cda Research Group, Inc. | System for use in producing a metal ion suspension and process of using same |
US11318089B2 (en) | 2013-03-15 | 2022-05-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1203308A (en) * | 1967-10-02 | 1970-08-26 | Miles Lab | Improvements in or relating to tableting lubricants and tableting processes |
US4112066A (en) * | 1976-06-21 | 1978-09-05 | Life Savers, Inc. | Breath freshener composition and method |
US4971785A (en) * | 1988-03-14 | 1990-11-20 | Spectrum Consumer Products Co., Inc. | Non-alcoholic delivery system for orally ingestible active ingredients |
EP0471396A1 (en) * | 1990-08-16 | 1992-02-19 | Unilever N.V. | Dental compositions containing stabilized copper |
US6030605A (en) * | 1997-04-03 | 2000-02-29 | Nabisco, Inc. | Breath freshening compositions and methods using them |
WO2000023040A1 (en) * | 1998-10-16 | 2000-04-27 | Fuisz Technologies Ltd. | Dry deodorizing composition for oral administration |
-
2000
- 2000-11-21 NO NO20005877A patent/NO20005877A/en not_active IP Right Cessation
-
2001
- 2001-11-19 AU AU2002224224A patent/AU2002224224A1/en not_active Abandoned
- 2001-11-19 WO PCT/NO2001/000458 patent/WO2002041862A1/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1203308A (en) * | 1967-10-02 | 1970-08-26 | Miles Lab | Improvements in or relating to tableting lubricants and tableting processes |
US4112066A (en) * | 1976-06-21 | 1978-09-05 | Life Savers, Inc. | Breath freshener composition and method |
US4971785A (en) * | 1988-03-14 | 1990-11-20 | Spectrum Consumer Products Co., Inc. | Non-alcoholic delivery system for orally ingestible active ingredients |
EP0471396A1 (en) * | 1990-08-16 | 1992-02-19 | Unilever N.V. | Dental compositions containing stabilized copper |
US6030605A (en) * | 1997-04-03 | 2000-02-29 | Nabisco, Inc. | Breath freshening compositions and methods using them |
WO2000023040A1 (en) * | 1998-10-16 | 2000-04-27 | Fuisz Technologies Ltd. | Dry deodorizing composition for oral administration |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11083750B2 (en) | 2013-03-15 | 2021-08-10 | Cda Research Group, Inc. | Methods of treatment using topical copper ion formulations |
EP3003247A4 (en) * | 2013-03-15 | 2017-01-04 | CDA Research Group, Inc. | Topical copper ion treatments |
US10398733B2 (en) | 2013-03-15 | 2019-09-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body |
US10813948B2 (en) | 2013-03-15 | 2020-10-27 | Cda Research Group, Inc. | Methods of treatment using topical copper ion formulations |
US11000545B2 (en) | 2013-03-15 | 2021-05-11 | Cda Research Group, Inc. | Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza |
US11007143B2 (en) | 2013-03-15 | 2021-05-18 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body |
AU2014235706B2 (en) * | 2013-03-15 | 2018-11-01 | Cda Research Group, Inc. | Topical copper ion treatments |
US11857514B2 (en) | 2013-03-15 | 2024-01-02 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body |
US11318089B2 (en) | 2013-03-15 | 2022-05-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body |
US11298316B2 (en) | 2013-03-15 | 2022-04-12 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body |
US11253544B2 (en) | 2013-03-15 | 2022-02-22 | Cda Research Group, Inc. | Methods of treatment using topical copper ion formulations |
US11717535B2 (en) | 2013-03-15 | 2023-08-08 | Cda Research Group, Inc. | Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza |
US11459638B2 (en) | 2019-02-22 | 2022-10-04 | Cda Research Group, Inc. | System for use in producing a metal ion suspension and process of using same |
US11193184B2 (en) | 2019-02-22 | 2021-12-07 | Cda Research Group, Inc. | System for use in producing a metal ion suspension and process of using same |
Also Published As
Publication number | Publication date |
---|---|
AU2002224224A1 (en) | 2002-06-03 |
NO312153B1 (en) | 2002-04-02 |
NO20005877D0 (en) | 2000-11-21 |
NO20005877A (en) | 2002-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Mathur et al. | Chlorhexidine: The gold standard in chemical plaque control | |
WO2006117029A1 (en) | Use of polylysine in combination with either green tea or olive extracts or both for use against halitosis | |
JPH0798737B2 (en) | Tartar prevention and oral deodorant solid composition | |
JPH10503196A (en) | Bactericidal toothpaste | |
WO2003103618A1 (en) | Compositions for oral cavity | |
US20020114767A1 (en) | Oral hygiene preparation for inhibiting halitosis | |
EP0920857A2 (en) | Oral composition for the treatment of halitosis | |
CN108403544A (en) | A kind of Pediatric Oral Emergency care composition and preparation method thereof | |
KR102638091B1 (en) | Toothpaste composition with whitening function | |
WO1999020238A1 (en) | Metal ion-containing oral products with reduced astringency | |
WO2002041862A1 (en) | An oral hygiene preparation for inhibiting halitosis | |
JP2013528618A (en) | Bad breath control method and product | |
JP4147412B2 (en) | Oral composition | |
WO2005072691A1 (en) | Composition for inhibiting halitosis | |
JP4919060B2 (en) | Oral composition and algin dipine inhibitor | |
JP2003095905A (en) | Deodorant for oral cavity | |
JPH11180840A (en) | Xylitol-containing tablet | |
JP2020083787A (en) | Composition for oral cavity | |
AU2006265330B2 (en) | Oral composition comprising dimethicone copolyol | |
JP2023533273A (en) | Oral composition for improving bad breath | |
EP1578349A2 (en) | Novel anti-bacterial compositions | |
JPH08268855A (en) | Composition for oral cavity | |
KR20090131586A (en) | Mastic-containing solution for rinsing mouth and its manufacturing method | |
JP2001139442A (en) | Liquid composition for oral cavity | |
JPWO2019216108A1 (en) | Oral composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |