WO2002008190A3 - Neue heteroaryl-derivate und deren verwendung als antitumormittel - Google Patents

Neue heteroaryl-derivate und deren verwendung als antitumormittel Download PDF

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Publication number
WO2002008190A3
WO2002008190A3 PCT/EP2001/008262 EP0108262W WO0208190A3 WO 2002008190 A3 WO2002008190 A3 WO 2002008190A3 EP 0108262 W EP0108262 W EP 0108262W WO 0208190 A3 WO0208190 A3 WO 0208190A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumour agents
heteroaryl derivatives
novel heteroaryl
novel
derivatives
Prior art date
Application number
PCT/EP2001/008262
Other languages
English (en)
French (fr)
Other versions
WO2002008190A2 (de
Inventor
Peter Emig
Eckhard Guenther
Juergen Schmidt
Bernhard Kutscher
Bernd Nickel
Anita Storch
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2001281989A priority Critical patent/AU2001281989B2/en
Priority to IL15393101A priority patent/IL153931A0/xx
Application filed by Zentaris Ag filed Critical Zentaris Ag
Priority to EP01960509A priority patent/EP1305289A2/de
Priority to NZ524156A priority patent/NZ524156A/en
Priority to BR0112711-0A priority patent/BR0112711A/pt
Priority to PL36135401A priority patent/PL361354A1/xx
Priority to JP2002514097A priority patent/JP2004516243A/ja
Priority to KR10-2003-7000880A priority patent/KR20030015894A/ko
Priority to SK194-2003A priority patent/SK1942003A3/sk
Priority to HU0300743A priority patent/HUP0300743A2/hu
Priority to AU8198901A priority patent/AU8198901A/xx
Priority to MXPA03000596A priority patent/MXPA03000596A/es
Publication of WO2002008190A2 publication Critical patent/WO2002008190A2/de
Publication of WO2002008190A3 publication Critical patent/WO2002008190A3/de
Priority to NO20030302A priority patent/NO20030302L/no
Priority to BG107506A priority patent/BG107506A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Die Erfindung betrifft neue Pyridin-Derivate der allgemeinen Formel (1), deren Herstellung und Verwendung als Arzneimittel, insbesondere zur Behandlung von Tumoren.
PCT/EP2001/008262 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel WO2002008190A2 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
SK194-2003A SK1942003A3 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
KR10-2003-7000880A KR20030015894A (ko) 2000-07-21 2001-07-18 신규한 헤테로아릴 유도체 및 약물로서의 이의 용도
EP01960509A EP1305289A2 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel
IL15393101A IL153931A0 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
BR0112711-0A BR0112711A (pt) 2000-07-21 2001-07-18 Derivados de heteroarila e seus usos como medicamentos
PL36135401A PL361354A1 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
HU0300743A HUP0300743A2 (hu) 2000-07-21 2001-07-18 Heteroarilszármazékok és alkalmazásuk gyógyszerként
AU2001281989A AU2001281989B2 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as anti-tumour agents
NZ524156A NZ524156A (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and their use as medicaments
JP2002514097A JP2004516243A (ja) 2000-07-21 2001-07-18 新規のヘテロアリール誘導体および該化合物の医薬品としての使用
AU8198901A AU8198901A (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and use thereof as medicaments
MXPA03000596A MXPA03000596A (es) 2000-07-21 2001-07-18 Nuevos derivasdos de heteroarilo y su uso como agentes antitumorales.
NO20030302A NO20030302L (no) 2000-07-21 2003-01-20 Nye heteroarylderivater og deres anvendelse som medikamenter
BG107506A BG107506A (bg) 2000-07-21 2003-01-30 Нови хетероарилови производни и тяхното използване като лекарствени средства

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035908A DE10035908A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035908.6 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002008190A2 WO2002008190A2 (de) 2002-01-31
WO2002008190A3 true WO2002008190A3 (de) 2002-08-01

Family

ID=7649970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008262 WO2002008190A2 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als antitumormittel

Country Status (21)

Country Link
US (1) US6638935B2 (de)
EP (1) EP1305289A2 (de)
JP (1) JP2004516243A (de)
KR (1) KR20030015894A (de)
CN (1) CN1447796A (de)
AR (1) AR032467A1 (de)
AU (2) AU2001281989B2 (de)
BG (1) BG107506A (de)
BR (1) BR0112711A (de)
CA (1) CA2353353A1 (de)
DE (1) DE10035908A1 (de)
HU (1) HUP0300743A2 (de)
IL (1) IL153931A0 (de)
MX (1) MXPA03000596A (de)
NO (1) NO20030302L (de)
NZ (1) NZ524156A (de)
PL (1) PL361354A1 (de)
RU (1) RU2003105238A (de)
SK (1) SK1942003A3 (de)
WO (1) WO2002008190A2 (de)
ZA (1) ZA200300545B (de)

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FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
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US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
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MX2009008253A (es) * 2007-01-31 2009-10-12 Vertex Pharma Derivados de 2-aminopiridina utiles como inhibidores de cinasa.
WO2008106128A2 (en) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
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EP2215089B1 (de) * 2007-11-02 2012-06-27 Vertex Pharmaceuticals Incorporated [1h-pyrazolo-[3, 4-b]-pyridin-4-yl]-phenyl- oder -pyridin-2-yl-derivate als proteinkinase c-theta
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EP2229368A1 (de) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Cyclische harnstoffe als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
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US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
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US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
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Also Published As

Publication number Publication date
BG107506A (bg) 2003-09-30
WO2002008190A2 (de) 2002-01-31
US20020111354A1 (en) 2002-08-15
HUP0300743A2 (hu) 2003-10-28
MXPA03000596A (es) 2003-05-14
JP2004516243A (ja) 2004-06-03
CA2353353A1 (en) 2002-01-21
NO20030302D0 (no) 2003-01-20
NZ524156A (en) 2005-10-28
AU8198901A (en) 2002-02-05
EP1305289A2 (de) 2003-05-02
AR032467A1 (es) 2003-11-12
BR0112711A (pt) 2003-05-20
NO20030302L (no) 2003-02-07
RU2003105238A (ru) 2004-08-10
SK1942003A3 (en) 2003-12-02
PL361354A1 (en) 2004-10-04
US6638935B2 (en) 2003-10-28
DE10035908A1 (de) 2002-03-07
IL153931A0 (en) 2003-07-31
KR20030015894A (ko) 2003-02-25
CN1447796A (zh) 2003-10-08
AU2001281989B2 (en) 2005-05-12
ZA200300545B (en) 2003-02-12

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