WO2001071346A3 - Binding compounds for cc chemokine receptor 5 and methods for identifying them - Google Patents

Binding compounds for cc chemokine receptor 5 and methods for identifying them Download PDF

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Publication number
WO2001071346A3
WO2001071346A3 PCT/US2001/009155 US0109155W WO0171346A3 WO 2001071346 A3 WO2001071346 A3 WO 2001071346A3 US 0109155 W US0109155 W US 0109155W WO 0171346 A3 WO0171346 A3 WO 0171346A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
identifying
binding compounds
chemokine receptor
compounds
Prior art date
Application number
PCT/US2001/009155
Other languages
French (fr)
Other versions
WO2001071346A2 (en
Inventor
John J Nestor Jr
Carol J Wilson
Raymond H See
Hehir Christina A Tan
Original Assignee
Consensus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/813,653 external-priority patent/US20020064770A1/en
Priority claimed from US09/813,448 external-priority patent/US20020142346A1/en
Priority claimed from US09/813,651 external-priority patent/US20030018438A1/en
Application filed by Consensus Pharmaceuticals Inc filed Critical Consensus Pharmaceuticals Inc
Priority to JP2001569482A priority Critical patent/JP2003528319A/en
Priority to EP01920642A priority patent/EP1268523A2/en
Priority to AU2001247674A priority patent/AU2001247674A1/en
Priority to CA002404139A priority patent/CA2404139A1/en
Publication of WO2001071346A2 publication Critical patent/WO2001071346A2/en
Publication of WO2001071346A3 publication Critical patent/WO2001071346A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • AIDS & HIV (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

Compositions of binding compounds for CC chemokine receptor 5 and methods for identifying binding compounds for CC chemokine 5 receptor are provided. Also provided are therapeutic agents comprising such compounds.
PCT/US2001/009155 2000-03-21 2001-03-21 Binding compounds for cc chemokine receptor 5 and methods for identifying them WO2001071346A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001569482A JP2003528319A (en) 2000-03-21 2001-03-21 Binding compounds to CC chemokine receptor 5 and methods for identifying them
EP01920642A EP1268523A2 (en) 2000-03-21 2001-03-21 Binding compounds for cc chemokine receptor 5 and methods for identifying them
AU2001247674A AU2001247674A1 (en) 2000-03-21 2001-03-21 Binding compounds and methods for identifying binding compounds
CA002404139A CA2404139A1 (en) 2000-03-21 2001-03-21 Binding compounds and methods for identifying binding compounds

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US19099600P 2000-03-21 2000-03-21
US19094600P 2000-03-21 2000-03-21
US19129900P 2000-03-21 2000-03-21
US60/190,946 2000-03-21
US60/191,299 2000-03-21
US60/190,996 2000-03-21
US09/813,653 US20020064770A1 (en) 2000-03-21 2001-03-20 Binding compounds and methods for identifying binding compounds
US09/813,448 US20020142346A1 (en) 2000-03-21 2001-03-20 Binding compounds and methods for identifying binding compounds
US09/813,448 2001-03-20
US09/813,651 US20030018438A1 (en) 2000-03-21 2001-03-20 Binding compounds and methods for identifying binding compounds
US09/813,653 2001-03-20
US09/813,651 2001-03-20

Publications (2)

Publication Number Publication Date
WO2001071346A2 WO2001071346A2 (en) 2001-09-27
WO2001071346A3 true WO2001071346A3 (en) 2002-09-12

Family

ID=27558818

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2001/009155 WO2001071346A2 (en) 2000-03-21 2001-03-21 Binding compounds for cc chemokine receptor 5 and methods for identifying them
PCT/US2001/040345 WO2001070765A1 (en) 2000-03-21 2001-03-21 Receptor-binding compounds and methods for identifying them
PCT/US2001/009160 WO2001070768A2 (en) 2000-03-21 2001-03-21 Receptor-binding compounds and method for identifying them

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2001/040345 WO2001070765A1 (en) 2000-03-21 2001-03-21 Receptor-binding compounds and methods for identifying them
PCT/US2001/009160 WO2001070768A2 (en) 2000-03-21 2001-03-21 Receptor-binding compounds and method for identifying them

Country Status (5)

Country Link
EP (3) EP1268521A1 (en)
JP (2) JP2003528319A (en)
AU (3) AU2001247675A1 (en)
CA (3) CA2403784A1 (en)
WO (3) WO2001071346A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056581A2 (en) * 2003-12-10 2005-06-23 Universite De Lausanne Peptide able to specifically bind a chemokine receptor and use thereof
EP1797428A1 (en) * 2004-10-04 2007-06-20 Alchemia Pty Ltd Selective inhibitors
GB0724860D0 (en) * 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
ES2540467T3 (en) * 2010-08-19 2015-07-09 Probiodrug Ag Crystalline structure of glutaminyl cyclase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532167A (en) * 1994-01-07 1996-07-02 Beth Israel Hospital Substrate specificity of protein kinases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLANPAIN: "CCR5 binds multiple CC-Chemokines: MCP-3 acts as a natural antagonist", BLOOD, vol. 94, 1999, pages 1899 - 1905, XP002196556 *
DATABASE INTERNET August 2000 (2000-08-01), KIBBLE; PAGES 1-5: "American Chemical Society 220th National Meeting (Part VII); 20-24 August 2000, Washington DC, USA", XP002196692 *
SUNDBERG: "High-throughput and ultra-high-throughput screening: solutions- and cell-based approaches", CURRENT OPINIONS IN BIOTECHNOLOGY, vol. 11, February 2000 (2000-02-01), pages 47 - 53, XP002196557 *
TARASOVA ET AL: "Inhibition of G-protein-coupled receptor function by disruption of transmembrane domain interactions", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 49, 3 December 1999 (1999-12-03), pages 34911 - 34915, XP002168073, ISSN: 0021-9258 *
YANOFSKY ET AL: "High affinity type I interleukin 1 receptor antagonists disocvered by screening recombinant peptide libraries", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, July 1996 (1996-07-01), pages 7381 - 7386, XP000985913, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2001070768A2 (en) 2001-09-27
WO2001070765A9 (en) 2003-02-06
EP1268520A2 (en) 2003-01-02
AU2001253870A1 (en) 2001-10-03
CA2404139A1 (en) 2001-09-27
EP1268521A1 (en) 2003-01-02
JP2004502134A (en) 2004-01-22
AU2001247675A1 (en) 2001-10-03
WO2001071346A2 (en) 2001-09-27
WO2001070768A3 (en) 2002-03-14
CA2403788A1 (en) 2001-09-27
AU2001247674A1 (en) 2001-10-03
JP2003528319A (en) 2003-09-24
CA2403784A1 (en) 2001-09-27
WO2001070765A1 (en) 2001-09-27
EP1268523A2 (en) 2003-01-02

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