WO2001036478A2 - Methods and compositions relating to bactericidal/permeability increasing factor-like polypeptides and polynucleotides - Google Patents

Methods and compositions relating to bactericidal/permeability increasing factor-like polypeptides and polynucleotides Download PDF

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WO2001036478A2
WO2001036478A2 PCT/US2000/031878 US0031878W WO0136478A2 WO 2001036478 A2 WO2001036478 A2 WO 2001036478A2 US 0031878 W US0031878 W US 0031878W WO 0136478 A2 WO0136478 A2 WO 0136478A2
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seq
set forth
amino acid
atomic coordinates
polypeptide
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PCT/US2000/031878
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WO2001036478A3 (en
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David G. Ballinger
Julio J. Mulero
Xiaohong Qian
Nancy K. Mize
Dana A. Haley
Bryan J. Boyle
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Hyseq, Inc.
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Priority to AU17826/01A priority Critical patent/AU1782601A/en
Publication of WO2001036478A2 publication Critical patent/WO2001036478A2/en
Publication of WO2001036478A3 publication Critical patent/WO2001036478A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Definitions

  • the present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins.
  • Bactericidal/permeability increasing factor is part of a family of mammalian lipid- binding proteins that include, hpopolysaccharide binding protein (LBP) , cholesteryl ester transfer protein (CETP) and phopholipid transfer protein (PLTP).
  • LBP hpopolysaccharide binding protein
  • CETP cholesteryl ester transfer protein
  • PLTP phopholipid transfer protein
  • BPI and LBP are involved in host response to bacterial infections and LPS
  • CETP and PLTP are lipid transport proteins which regulate the size and composition of LDL and HDL in the bloodstream.
  • LBP bacterial lipopolysaccharides
  • LPS bacterial lipopolysaccharides
  • B.PI binds LPS and has a cytotoxic activity on Gram-negative bacteria.
  • CETP is involved in the transfer of insoluble cholesteryl esters in reverse cholesterol transport.
  • PLTP is thought to play a key role in extracellular phospholipid transport and modulation of HDL particles.
  • compositions of the present invention include novel isolated polypeptides, in particular, novel bactericidal/permeability increasing factor (BPI) - like polypeptides and isolated polynucleotides encoding such polypeptides.
  • BPI novel bactericidal/permeability increasing factor
  • the present invention encompasses a method for identifying a composition having bactericidal/permeability increasing factor-like (BPIL) biological activity, the method comprising the steps of: (a) providing a molecular model comprising atomic coordinates defining a three-dimensional shape representative of at least a portion of BPIL; (b) identifying a candidate analog having a three-dimensional shape corresponding to the three-dimensional shape representative of at least a portion of BPIL; and (c) producing the candidate analog identified in step (b).
  • the compound produced in step (c) has BPIL-like biological activity.
  • steps (a) and (b) are performed by means of an electronic processor and step (a) comprises storing a representation of at least a portion of the atomic coordinates of BPIL in a computer memory.
  • Another aspect of the invention is a computer system comprising: (a) a memory comprising atomic coordinates defining at least a portion of BPIL; and (b) a processor in electrical communication with the memory, wherein the processor generates a molecular model having a three-dimensional shape representative of at least a portion of BPIL.
  • the coordinates are stored on a computer readable diskette.
  • the molecular model is representative of at least a portion of BPIL binding pocket region.
  • Another aspect of the invention is a computer comprising a memory containing a three- dimensional representation of BPIL or a portion of BPIL that includes the binding region of BPIL.
  • Another aspect of the invention comprises a machine readable data storage medium, a data storage material coded with machine readable data, the data including the three-dimensional representation, and further wherein the data includes a three-dimensional representation of BPIL or of a portion of BPIL that includes the BPIL binding pocket region.
  • Another aspect of the invention is a machine readable data storage medium, wherein the three-dimensional representation is substantially defined by the atomic coordinates of the amino aids comprising SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45.
  • Yet another aspect of the invention is a BPIL NH 2 or COOH binding pocket amino acid sequence, the amino acid sequence comprising two or more binding pocket residues substantially defined by the atomic coordinates of the amino acid sequences of SEQ ID NO:2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45 which are underlined in the Query sequences as set forth in the Tables with the atomic coordinates of these underlined amino acids being set forth in Table 49-59.
  • a still further aspect of the invention is a method for identifying a potential modulator of BPIL biological activity, the method comprising the following steps: (1) designing or selecting a potential modulator of BPIL biological activity by utilizing a three-dimensional structure of a BPIL NH 2 or COOH binding pocket amino acid sequence comprising two or more pocket binding residues substantially defined by the atomic coordinates of the amino acid sequences of SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45 which are underlined in the Query sequences as set forth in the Tables, with the atomic coordinates of these underlined amino acids being set forth in Tables 49-59; and (2) contacting the potential modulator with BPIL in the presence of a protein which binds to the BPIL superfamily to test the ability of the potential modulator to modulate the interaction between BPIL and the protein which binds to BPIL.
  • compositions of the present invention include isolated polypeptides at least 80% identical to a polypeptide comprising an amino acid sequence of SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, or 45, as well as fragments, derivatives, analogs, homologs, and naturally occurring allelic variants thereof.
  • the polypeptides of the present invention further comprise an NH 2 terminal barrel domain, a central ⁇ sheet domain, and a COOH-terminal barrel domain.
  • the present polypeptides comprise a binding pocket domain.
  • the polypeptides can further comprise a cysteine-cysteine disulfide bond within the NH 2 terminal barrel domain.
  • a further embodiment is an isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence of SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, or 45, as well as fragments, derivatives, analogs, homologs, and naturally occurring allelic variants thereof.
  • Another embodiment includes isolated nucleic acid molecules at least 80% identical to the nucleotide sequence of SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, or 44, as well as fragments, derivatives, analogs, and homologs thereof.
  • Further embodiments include vectors comprising the polynucleotides of the invention and host cells genetically engineered to express the polynucleotides. Additional embodiments include antibodies that bind to the polypeptide of the invention.
  • Another aspect is a method for determining the presence or amount of the polypeptide of the invention in a sample, the method comprising: (a) introducing the sample to an antibody that binds to the polypeptide; and (b) determining the presence or amount of antibody bound to said polypeptide, thereby determining the presence or amount of polypeptide in the sample.
  • Yet another aspect is a method for identifying a potential therapeutic agent for use in treatment of a pathology, wherein the pathology is related to aberrant expression or aberrant physiological interactions of the polypeptides of this invention, the method comprising: (a) providing a cell expressing the polypeptide and having a property or function ascribable to the polypeptide; (b) contacting the cell with a composition comprising a candidate substance; and (c) determining whether the substance alters the property or function ascribable to the polypeptide; whereby, if an alteration observed in the presence of the substance is not observed when the cell is contacted with a composition devoid of the substance, the substance is identified as a potential therapeutic agent.
  • compositions comprising the polypeptides of the invention and a pharmaceutically acceptable carrier, and a pharmaceutical composition comprising the nucleic acid molecules of the invention and a pharmaceutically acceptable carrier.
  • Figure 4. is an illustration of the ribbon diagrams of BPIL 196-1 predicted three dimensional structure.
  • Figure 5 is an illustration of the ribbon diagrams of BPIL 196-2 predicted three dimensional structure
  • Figure 6. is an illustration of the ribbon diagrams of BPIL 232-1 predicted three dimensional structure.
  • Figure 7 is an illustration of the ribbon diagrams of BPIL 232-2 predicted three dimensional stmcture
  • Figure 8 is an illustration of the ribbon diagrams of BPIL 232-3 predicted three dimensional structure.
  • Figure 9 is an illustration of the ribbon diagrams of BPIL 232-4 predicted three dimensional structure
  • Figure 10 is an illustration of the ribbon diagrams of BPIL 232-5 predicted three dimensional structure.
  • Figure 11 is an illustration of the ribbon diagrams of BPIL 232-6 predicted three dimensional structure.
  • Figure 12 is an illustration of the ribbon diagrams of BPIL 325-3 predicted three dimensional structure
  • Figure 13 is an illustration of the ribbon diagrams of BPIL 325-4 predicted three dimensional structure.
  • Bactericidal/permeability-increasing protein like (BPIL) nucleotides and polypeptides encoded thereby.
  • Bactericidal/permeability-increasing protein (BPI) belongs to a superfamily of functionally related proteins that include hpopolysaccharide binding protein (LBP), cholesteryl ester transfer protein (CETP) and phopholipid transfer protein (PLTP). Included in the invention are the novel nucleic acid sequences and their polypeptides.
  • BPILX nucleic acids or BPILX polynucleotides
  • BPILX polypeptides or "BPILX proteins.”
  • BPILX is meant to refer to any of the novel sequences disclosed herein. Table 1 provides a summary of the BPILX nucleic acids and their encoded polypeptides.
  • BPILX nucleic acids, and their encoded polypeptides, according to the invention are useful in a variety of applications and contexts.
  • BPILX nucleic acids and polypeptides can be used to identify proteins that are members of the bactericidal/permeability-increasing protein superfamily.
  • the BPILX nucleic acids and polypeptides can also be used to screen for molecules which inhibit or enhance BPILX activity or function.
  • the nucleic acids and polypeptides according to the invention may be used as targets for the identification of small molecules that modulate, e.g., antibiotics, cytokine production, immune function.
  • These molecules can be used to treat, e.g., bacteremia, endotoxemia, inflammatory bowel disease, cystic fibrosis, gingivitis, peridontitis, septic shock, cystic fibrosis, meningoccemia or hemorrhagic trauma in mammals, e.g. humans.
  • BPILX nucleic acids and polypeptides according to the invention are useful, inter alia, as novel members of the protein families according to the presence of domains and sequence relatedness to previously described proteins.
  • the BPILX nucleic acids and their encoded polypeptides include secondary structural motifs that are characteristic of proteins belonging to the bactericidal/permeability-increasing protein superfamily.
  • the BPILX nucleic acids and their encoded polypeptides include tertiary structural motifs similar to human bactericidal/permeability-increasing protein.
  • the molecular models of the BPILX polypeptides according to the invention demonstrate that the BPILX polypeptides form a boomerang-shaped molecule with two domains (an amino and carboxy terminal) that are connected by a proline rich linker which is consistent with other members of the bactericidal/permeability- increasing protein superfamily.
  • the amino and carboxy domains each form a barrel containing a short ⁇ -helix, a five-stranded antiparallel ⁇ -sheet and a long helix.
  • the barrels are connected by a central ⁇ -sheet.
  • a single disulfide bond anchors the long helix and the final strand of the ⁇ -sheet within the amino terminal barrel.
  • BPILX nucleic acids and polypeptides, antibodies and related compounds according to the invention will be useful in therapeutic applications implicated in, e.g., septic shock, cystic fibrosis, inflamatory bowel disease, gingivitis, periodontitis, meningoccemia or hemorrhagic trauma.
  • BPILX nucleic acids, polypeptides, antibodies and related compounds of the invention may be used to modulate, e.g., inflammation, immune function and cytokine production.
  • BPILX nucleic acids are highly expressed in diseased tonsils, suggesting a potential therapeutic application of BPILX nucleic acids and polypeptides as diagnostic markers for tonsil disease, such as for example, tonsillitis, and tonsil Hodgkin disease.
  • BPILX nucleic acids are also expressed in a variety of cell types, e.g, adult bone marrow, fetal skin, fetal lymphocytes and adult trachea. Accordingly, the BPILX nucleic acids, polypeptides and antibodies according to the invention may be used in tissue typing analysis to identify these cell types.
  • BPIL-196 Two novel BPIL-196 genes were identified, BPIL 196-1 and BPIL 196-2 (hereinafter collectively referred to as "BPIL-196").
  • a BPIL- 196-1 nucleic acid and its encoded polypeptide include the sequences shown in Table 2, whereas a BPIL- 196-2 nucleic acid and its encoded polypeptide include the sequences shown in Table 3.
  • the disclosed BPIL-196-1 nucleic acid contains a 1373 nucleotide open reading frame (ORF, SEQ ID NO: 11) that begins with an ATG initiation codon at nucleotides 80- 82.
  • the representative ORF includes a 458 amino acid polypeptide (SEQ ID NO: 2).
  • the program Topred-II predicts a signal peptidase cleavage site at approximately between amino acids 20 and 21.
  • the disclosed BPIL-196-2 nucleic acid contains a 1373 nucleotide open reading frame (ORF, SEQ ID NO: 12) that begins with an ATG initiation codon at nucleotides 80- 82.
  • the representative ORF includes a 458 amino acid polypeptide (SEQ ID NO: 4).
  • the program Topred-II predicts a signal peptidase cleavage site at approximately between amino acids 20 and 21.
  • One of skill in the art could confirm this cleavage site by expressing the mature protein.
  • nucleotide 609 of SEQ ID NO: 1 is a cytosine whereas the nucleotide 609 of SEQ ID NO: 2 is thymine. This difference results in a change in amino acid residue 177 from a threonine in BPIL-196-1 to an isoleucine in BPIL 196-2.
  • the BPIL-196 encoded polypeptides have homology (approximately 59% similarity) to human BPI precursor (GenBank Ace. No. AAA51841).
  • Analysis of the BPIL 196 nucleic acid and polypeptide sequences revealed a bactericidal/ permeability increasing factor (BPI)-like high complementarity region which was identified at at nucleotide positions 146-241 (amino acid residues 23-54) and a polyadenylation signal which was identified as beginning at nucleotide position 1457.
  • BPI bactericidal/ permeability increasing factor
  • a search of the NCBI CD-Search database demonstrated that BPIL 196-1 shows significant similarity to three bactericidal/permeability-increasing protein superfamily domains, as shown in Table 4.
  • the NCBI CD-Search is a search of a conserved domain database. Because proteins often contain several modules or domains, each with a distinct evolutionary origin and function, the CD- Search service may be used to identify the conserved domains present in a protein sequence. Computational biologists define conserved domains based on recurring sequence patterns or motifs. CD currently contains domains derived from two popular collections, Smart and Pfam, plus contributions from NCBI. To identify conserved domains in a protein sequence, the CD-Search service employs the reverse position-specific BLAST algorithm. The query sequence is compared to a position-specific score matrix prepared from the underlying conserved domain alignment. Altschul et al., Nucleic Acids Res. 25:3389-3402 (1997). Similar results were found for BPIL 196- 2 , as shown in Table 5.
  • CD multiple alignments of the bactericidal/permeability-increasing protein superfamily domains are presented in Table 6. Black outlined amino acids indicates identity, whereas grey outlined amino acids indicates conservative substitution. Based on its relatedness, the BPIL-196 proteins are novel members of the bactericidal/permeability-increasing protein superfamily.
  • BPIL-196 polypeptides were modeled using the crystal structure of human bactericidal/permabihty increasing protein ("BPI") (Beamer et al. Science 276, 1997) using GeneAtlasTM software (Molecular Simulations, Inc. ("MSI”) San Diego, CA). The model demonstrated tertiary structure similar to BPI. Specifically, the BPIL-196 protein structure has the characteristic boomerang-shape with two domains of other members of the bactericidal/permeability-increasing protein superfamily. Structural overlays of the molecular model of BPIL-196-1 and BPIL-196-2 against BPI using the program Prof ⁇ le-3D were performed.
  • Profile 3-D is a threading program which measures the compatibility of the protein model with its sequence using a 3-D profile. Using defined parameters Profile 3-D computes a verify score for the model. A verify score between 0 and 1 correlates to a good model. A verify score under 0 correlates to a bad model. A verify score of 0.49 with 20.2% identity was obtained for BPIL-196-1. Simarily, the verify score for BPIL-196-2 is 0.33, with 21% identity. This confirms the tertiary structural similarity between BPIL-196 and BPI.
  • Tables 7 and 8 illustrate the primary sequence alignment with secondary structures of BPI.
  • both BPIL 196-1 and 196-2 have the conserved cysteine residues that are involved in disulfide bond formation between the final stand of the beta sheet and the long alpha helix. Consistent with the conserved tertiary structure, Tables 7 and 8 also illustrate that much of the amino acids in regions of secondary structure are conserved between BPIL-196 and BPI.
  • H-H one residue breaks in an alpha helix structure
  • S S disulfide bond
  • Table 8 Primary Sequence Alignment ofBPIL 196-2 with Secondary Structure ofBPI >HHHHHHHHHHHHHHHHHHHHH > Sbj ct : 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIRE 60 PG WR+ + + L Y S+ G A LQ+ L ++ +P + D + + L I
  • H-H one residue breaks in an alpha helix structure
  • S S disulfide bond
  • Binding pocket means the site where a BPILX ligand interacts (e.g., charge interaction, hydrophobic forces, van der Waals attraction, hydrogen bonding, dipole interaction and entropy increases) with a BPILX polypeptide.
  • these include amino acid val26, leu29, val37, ser38, ile40, pro44, leu ⁇ l, tyrl20, vall22, asnl79, glyl83, vall84, hisl87, leul88, ile218, ala255, pro429, gly430, asn433 of SEQ ID NO:2 as illustrated by underlining in Table 9 (SEQ ID NO:72).
  • the BPILX sequence of the present invention is the Query and the BPI Accession No. AAA51841 is the Subject.
  • the binding pocket can be defined by at least 2, 3, 4, or 5 of the above-designated amino acids.
  • Residues underlined are ones that are within 4 angstroms of the NH 2 - terminal lipid in the BPI crystal structure .
  • BPIL-232 Six novel BPIL-232 genes were identified, BPIL 232-1, BPIL 232-2, BPIL 232-3, BPIL 232-4, BPIL 232-5, BPIL 232-6 (hereinafter collectively referred to as "BPIL-232").
  • a BPIL-232 nucleic acid and its encoded polypeptide include the sequences shown in Table 13-18.
  • the disclosed BPIL-232- 1 nucleic acid contains a 1427 nucleotide open reading frame (ORF, SEQ ID NO: 13) that begins with an ATG initiation codon at nucleotides 94- 96.
  • the representative ORF includes a 476 amino acid polypeptide (SEQ ID NO: 6).
  • the program Signal P predicts a signal peptidase cleavage site between amino acids 23 and 24.
  • the disclosed BPIL-232-2 nucleic acid contains a 1427 nucleotide open reading frame (ORF, SEQ ID NO: 14) that begins with an ATG initiation codon at nucleotides 94- 96.
  • the representative ORF includes a 476 amino acid polypeptide (SEQ ID NO: 8).
  • the program Signal P predicts a signal peptidase cleavage site between amino acids 23 and 24.
  • the disclosed BPIL-232-3 nucleic acid contains a 1518 nucleotide open reading frame (ORF, SEQ ID NO: 30) that begins with an ATG initiation codon at nucleotides ???.
  • the representative ORF includes a 507 amino acid polypeptide (SEQ ID NO: 27).
  • the program Signal P predicts a signal peptidase cleavage site between amino acids 23 and 24.
  • the disclosed BPIL-232-4 nucleic acid contains a 1367 nucleotide open reading frame (ORF, SEQ ID NO: 31) that begins with an ATG initiation codon.
  • the representative ORF includes a 455 amino acid polypeptide (SEQ ID NO: 29).
  • the program Signal P predicts a signal peptidase cleavage site between amino acids 23 and 24.
  • the disclosed BPIL-232-5 nucleic acid (SEQ ID NO: 38) contains a 1518 nucleotide open reading frame (ORF, SEQ ID NO: 42) that begins with an ATG initiation codon.
  • the representative ORF includes a 507 amino acid polypeptide (SEQ ID NO: 39).
  • the program Signal P predicts a signal peptidase cleavage site between amino acids 23 and 24.
  • the disclosed BPIL-232-6 nucleic acid contains a 1367 nucleotide open reading frame (ORF, SEQ ID NO: 43) that begins with an ATG initiation codon.
  • the representative ORF includes a 455 amino acid polypeptide (SEQ ID NO: 41).
  • the program Signal P predicts a signal peptidase cleavage site between amino acids 23 and 24.
  • BPIL 232-1 and 232-2 differ by a single nucleotide polymorphism at nucleotide 1444.
  • nucleotide 1444 of SEQ ID NO: 5 is a cytosine whereas the nucleotide 1444 of SEQ ID NO: 7 is thymine. This difference results in a change in BPIL-232-6 amino acid residue 451 from a proline in BPIL-232- 1 to a serine in BPIL-232-2.
  • BPIL-232-3 and BPIL-232-5 differ by a single nucleotide polymorphism at nucleotide 1444.
  • nucleotide 1444 of SEQ ID NO: 38 is a cytosine whereas the nucleotide 1444 of SEQ ID NO: 26 is thymine. This difference results in a change in amino acid residue 451 from a proline in BPIL-232-5 to a serine in BPIL-232-3.
  • BPIL-232-6 and BPLI-232-4 differ by a single nucleotide polymorphism at nucleotide 1288.
  • nucleotide 1288 of SEQ ID NO: 40 is a cytosine whereas the nucleotide 1288 of SEQ ID NO: 28 is thymine. This difference results in a change in amino acid residue 399 from a proline in BPIL-232-6 to a serine in BPIL-232-4.
  • BPI bactericidal/ permeability increasing factor
  • the BPIL-232 encoded polypeptides have homology (approximately 59% similarity) to human BPI precursor (GenBank Ace. No. AAA51841).
  • BPIL 232 has significant similarity to multiple bactericidal/permeability-increasing protein superfamily domains, as shown in Table 19.
  • GnllSmartlBPI2 BPI LBP/CETP C-terminal domain Bactericidal permeability-incr.. 120 le-28 gnllPfamlpfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 113 2e-26 gnllPfamlpfam01273 LBP BPI CETP, LBP / BPI / CETP family 56.2 4e-09 gnllSmartlBPIl BPI/LBP/CETP N-terminal domain; Bactericidal permeability-incr.. 64.0 2e-l l
  • CD multiple alignments of the bactericidal/permeability-increasing protein superfamily domains are presented in Table 20. Black outlined amino acids indicates identity, whereas grey outlined amino acids indicates conservative substitution. Based on its relatedness, the BPIL-232 proteins are novel members of the bactericidal/permeability-increasing protein superfamily.
  • BPIL-232 polypeptides were also modeled using the crystal structure of human bactericidal/permeability increasing protein ("BPI") (Beamer et al. Science 276, 1997) using GeneAtlas software. The models demonstrated tertiary structure similar to BPI. Specifically, the BPIL-232 protein structure has the characteristic boomerang-shape with two domains of other members of the bactericidal/permeability-increasing protein superfamily.
  • BPI human bactericidal/permeability increasing protein
  • Profile 3-D is a threading program which measures the compatibility of the protein model with its sequence using a 3-D profile. Using defined parameters Profile 3-D computes a verify score for the model. A verify score between 0 and 1 correlates to a good model. A verify score under 0 correlates to a bad model.
  • Tables 22-27 illustrate the primary sequence alignment with secondary structures of BPI. As illustrated in Tables 22-27 all the BPIL-232 polypeptides have the conserved cysteine residues that are involved in disulfide bond formation between the final strand of the beta sheet and the long alpha helix. Consistent with the conserved teriary structure, Tables 22-27 also illustrate that much of the amino acids in regions of secondary structure are conserved between BPIL-232 and BPI.
  • H-H one residue breaks in an alpha helix structure
  • S S disulfide bond
  • Residues 17-45, 82-108, and 142-169 of BPI are considered critical for LPS-binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.276 2 0JUNE 1997pl861).
  • NAKLQQGFPLSNPHKFLFVNSDIEVLEVRMQ 471 (Seq ID No: 122)
  • H-H one residue breaks in an alpha helix structure
  • H denotes alpha helix secondary structure
  • > denotes beta-strand secondary structure (variable amounts of hyphens .
  • H-H one residue breaks in an alpha helix structure
  • Residues 17-45, 82-108, and 142-169 of BPI are considered critical for LPS-binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.276 20JUNE 1997p!86l).
  • Table 25 Primary Sequence Alignment ofBPIL 232-4 with Secondary Structure ofBPI >HHHHHHHHHHHHHHHHHHH > Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
  • H-H one residue breaks in an alpha helix structure
  • S S disulfide bond
  • Residues 17-45, 82-108, and 142-169 of BPI are considered critical for LPS-binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.27620JUNE 1997pi861).
  • NAKLQQGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 479 (Seq ID No: 128)
  • the subject line represents the BPI sequence and the query line represents the BPILX sequence.
  • Table 27 Primary Sequence Alignment of BPIL 232-6 with Secondary Structure of BPI >HHHHHHHHHHHHHHHHHHH > Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH- -YSFYSMDI 58
  • H denotes alpha helix secondary structure
  • > denotes beta-strand secondary structure (variable amounts of hyphens .
  • H-H one residue breaks in an alpha helix structure
  • S S disulfide bond
  • binding pocket is meant to be the site where a BPILX ligand interacts (e.g. charge interaction, hydrophobic forces, van der Waals attraction, hydrogen bonding, dipole interactionn and entropy increases) with a BPILX polypeptide.
  • BPILX sequence of the present invention is the Query and the BPI known sequence is the Subject.
  • NAKLQQGFPLSNPHKFLFVNSDIEVLEVRMQ 471 Seq ID No : 134 .
  • NAKLQQGFPLSNPHKFLFVNSDIEVLEVRMQ 471 (Seq ID No: 131)
  • NAKLQQGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 479 Seq ID No : 142 .
  • NAKLQOGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 479 (Seq ID No : 146)
  • Residues 17-45, 82-108, and 142-169 of BPI are considered critical for LPS-binding, LPS-neutralizing, and bactericidal activity, according to Beamer et al . (Science Vol. 276 20 June 1997 pl861) .
  • BPIL-325 genes Four novel BPIL-325 genes were identified, BPIL-325-1 , BPIL-325-2, BPIL-325-3, and
  • BPIL-325-4 (hereinafter referred to collectively as "BPIL-325").
  • a BPIL-325-1 nucleic acid and its encoded polypeptide include the sequences shown in Table 40, whereas a BPIL-325-2 nucleic acid and its encoded polypeptide include the sequences shown in Table 41.
  • a BPIL-325-3 nucleic acid and its encoded polypeptide include the sequences shown in Table 42.
  • a BPIL-325-4 nucleic acid and its encoded polypeptide include the sequences shown in Table 43.
  • the disclosed BPIL-325-1 nucleic acid (SEQ ID NO: 9) contains a 327 nucleotide open reading frame (ORF, SEQ ID NO: 15).
  • the representative ORF includes a 109 amino acid polypeptide (SEQ ID NO: 10).
  • the disclosed BPIL-325-2 nucleic acid contains a 450 nucleotide open reading frame (ORF, SEQ ID NO: 34).
  • the representative ORF includes a 150 amino acid polypeptide (SEQ ID NO: 32).
  • the disclosed BPIL-325-3 nucleic acid contains a 1362 nucleotide open reading frame (ORF, SEQ ID NO: 35) that begins with an ATG initiation codon at nucleotides 1-3.
  • the representative ORF includes a 454 amino acid polypeptide (SEQ ID NO: 35).
  • the program Signal D predicts a signal peptidase cleavage site between amino acids 1 and 23.
  • the disclosed BPIL-325-4 nucleic acid contains a 1362 nucleotide open reading frame that encodes an amino acid polypeptide (SEQ ID NO: 45).
  • the program Neural Network SignalP, predicts a signal peptidase cleavage site between amino acids 16 and 17.
  • Analysis of the BPIL-325-4 and BPIL-325-3 sequences identified that the nucleotides GTG after C97 was missing in the BPIL-325-4 sequence. This results in an amino acid change of Gin to Val after Asn32 instead of Arg-Glu as in BPIL-325-3.
  • Table 40 325-1 Nucleic Acid and Polypeptide Sequences cggacgcgtg ggtcgcccac gcgtccggtg agctgccccc acaaaccacc aagaccctgg 60 ctcgcttcat tcctgaagtg gctgtagctt atcccaagtc aaagcccttg acgacccaga 120 tcaagataaa gaagcctccc aaggtcact atg aag aca ggc aag age ctg ctg 173
  • BPIL-325 encoded polypeptides have homology (approximately 50% similarity) to human BPI precursor (GenBank Ace. No. AAA51841).
  • a search of the NCBI CD-Search database demonstrated that BPIL 325-2, 355-3 and 325-4 have significant similarity to multiple bactericidal/permeability-increasing protein superfamily domains, as shown in Table 44.
  • CD multiple alignments of the bactericidal/permeability-increasing protein superfamily domains are presented in Table 45. Black outlined amino acids indicates identity, whereas grey outlined amino acids indicates conservative substitution. Based on its relatedness, the BPIL-325-2, 325-3 and 325-4 proteins are novel members of the bactericidal/permeability-increasing protein superfamily.
  • BPIL-325-2, 325-3 and 325-4 polypeptides were modeled using the crystal structure of human BPI (Beamer et al. Science 276, 1997) using GeneAtlas software. The model demonstrated tertiary structure similar to BPI. Specifically, the BPIL-325 protein structure has the characteristic boomerang-shape with two domains of other members of the bactericidal/permeability-increasing protein superfamily. Structural overlays of the molecular model of BPIL-325 against BPI using the program Profile-3D were performed.
  • Profile 3-D is a threading program which measures the compatibility of the protein model with its sequence using a 3-D profile. Using defined parameters Profile 3-D computes a verify score for the model. A verify score between 0 and 1 correlates to a good model. A verify score under 0 correlates to a bad model.
  • BPIL325-4 polypeptide has the conserved cysteine residues that are involved in disulfide bond formation between the final strand of the beta sheet and the long alpha helix. Consistent with the conserved tertiary structure, Table 46 also illustrates that much of the amino acids in regions of secondary structure are conserved between BPIL-325 and BPI.
  • H denotes alpha helix secondary structure
  • > denotes beta-strand secondary structure (variable amounts of hyphens .
  • H-H one residue breaks in an alpha helix structure
  • binding pocket is meant to be the site where a BPILX ligand interacts (e.g. charge interaction, hydrophobic forces, van der Waals attraction, hydrogen bonding, dipole interactionn and entropy increases) with a BPILX polypeptide.
  • BPILX sequence of the present invention is the Query and the BPI known sequence is the subject.
  • Table 60 Primary Sequence Alignment of BPIL 325-3 with Secondary Structure of BPI >HHHHHHHHHHHHHHHHHHH >
  • V 4- 4- L 4- 4- 4- Y L++ PATTA 4- 4- 4- A
  • H-H one residue breaks in an alpha helix structure disulfide bond
  • Table 61 BPIL 325-3 N-terminal binding pocket Sbjct: 2 NPGVyVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREF 61 +PG ++R+ G+D +++ +A+ + K+ ++ K + K ++ +++ Query: 19 DPGALLRL GMDIMNREVQSAMDESHILEKMAA- -EAGKKQPGMKPIKGITNLKVKDV 73
  • nucleotide sequence refers to a heteropolymer of nucleotides or the sequence of these nucleotides.
  • nucleic acid and polynucleotide are also used interchangeably herein to refer to a heteropolymer of nucleotides.
  • nucleic acid segments provided by this invention may be assembled from fragments of the genome and short oligonucleotide linkers, or from a series of oligonucleotides, or from individual nucleotides, to provide a synthetic nucleic acid which is capable of being expressed in a recombinant transcriptional unit comprising regulatory elements derived from a microbial or viral operon, or a eukaryotic gene.
  • a nucleotide sequence, polynucleotide or nucleic acid can correspond to a genomic sequence (e.g., can contain intron as well as exon sequence) or cDNA sequences (that is, contains no intron sequence).
  • oligonucleotide fragment or a "polynucleotide fragment", "portion,” or
  • segment is a stretch of polypeptide nucleotide residues which is long enough to use in polymerase chain reaction (PCR) or various hybridization procedures to identify or amplify identical or related parts of mRNA or DNA molecules.
  • PCR polymerase chain reaction
  • oligonucleotides or "nucleic acid probes” are prepared based on the polynucleotide sequences provided in the present invention. Oligonucleotides comprise portions of such a polynucleotide sequence having at least about 15 nucleotides and usually at least about 20 nucleotides. Nucleic acid probes comprise portions of such a polynucleotide sequence having fewer nucleotides than about 6 kb, usually fewer than about 1 kb. After appropriate testing to eliminate false positives, these probes may, for example, be used to determine whether specific mRNA molecules are present in a cell or tissue or to isolate similar nucleic acid sequences from chromosomal DNA as described by Walsh et al. (Walsh, P.S. et al., 1992, PCR Methods Appl 1:241-250).
  • probes includes naturally occurring or recombinant or chemically synthesized single- or double-stranded nucleic acids. They may be labeled by nick translation, Klenow fill-in reaction, PCR or other methods well known in the art. Probes of the present invention, their preparation and/or labeling are elaborated in Sambrook, J. et al., 1989, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY; or Ausubel, F.M. et al., 1989, Current Protocols in Molecular Biology, John Wiley & Sons, New York NY, both of which are incorporated herein by reference in their entirety.
  • oligonucleotide fragment is at least about 15, and preferably at least about 50, 100, 200, 300, 400, 500, 600, 700 or 800 nucleotides in length.
  • stringent is used to refer to conditions that are commonly understood in the art as stringent.
  • Stringent conditions can include highly stringent conditions (i.e., hybridization to filter-bound DNA under in 0.5 M NaHP04, 7% sodium dodecyl sulfate (SDS), 1 mM EDTA at 65° C, and washing in O.lxSSC/0.1% SDS at 68 C), and moderately stringent conditions (i.e., washing in 0.2xSSC/0.1% SDS at 42° C).
  • additional exemplary highly stringent hybridization conditions include washing in 6xSSC/0.05% sodium pyrophosphate at 37°C (for 14-base oligos), 48°C (for 17-base oligos), 55°C (for 20-base oligos), and 60°C (for 23-base oligos).
  • recombinant when used herein to refer to a polypeptide or protein, means that a polypeptide or protein is derived from recombinant (e.g., microbial or mammalian) expression systems.
  • Microbial refers to recombinant polypeptides or proteins made in bacterial or fungal (e.g., yeast) expression systems.
  • recombinant microbial defines a polypeptide or protein essentially free of native endogenous substances and unaccompanied by associated native glycosylation.
  • polypeptides or proteins expressed in most bacterial cultures will be free of glycosylation modifications; polypeptides or proteins expressed in yeast will have a glycosylation pattern in general different from those expressed in mammalian cells.
  • the term "recombinant expression vehicle or vector” refers to a plasmid or phage or virus or vector, for expressing a polypeptide from a DNA (RNA) sequence.
  • An expression vehicle can comprise a transcriptional unit comprising an assembly of (1) a genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers, (2) a structural or coding sequence which is transcribed into mRNA and translated into protein, and (3) appropriate transcription initiation and termination sequences.
  • Structural units intended for use in yeast or eukaryotic expression systems preferably include a leader sequence enabling extracellular secretion of translated protein by a host cell.
  • recombinant protein may include an N-terminal methionine residue. This residue may or may not be subsequently cleaved from the expressed recombinant protein to provide a final product.
  • recombinant expression system means host cells which have stably integrated a recombinant transcriptional unit into chromosomal DNA or carry the recombinant transcriptional unit extrachromosomally.
  • Recombinant expression systems as defined herein will express heterologous polypeptides or proteins upon induction of the regulatory elements linked to the DNA segment or synthetic gene to be expressed.
  • This term also means host cells which have stably integrated a recombinant genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers.
  • Recombinant expression systems as defined herein will express polypeptides or proteins endogenous to the cell upon induction of the regulatory elements linked to the endogenous DNA segment or gene to be expressed.
  • the cells can be prokaryotic or eukaryotic.
  • ORF open reading frame
  • EMF expression modulating fragment
  • a sequence is said to "modulate the expression of an operably linked sequence" when the expression of the sequence is altered by the presence of the EMF.
  • EMFs include, but are not limited to, promoters, and promoter modulating sequences (inducible elements).
  • One class of EMFs are fragments which induce the expression or an operably linked ORF in response to a specific regulatory factor or physiological event.
  • an "uptake modulating fragment,” UMF means a series of nucleotides which mediate the uptake of a linked DNA fragment into a cell. UMFs can be readily identified using known UMFs as a target sequence or target motif with the computer-based systems described below.
  • UMF UMF
  • active refers to those forms of the polypeptide which retain the biological and/or immunological activities of any naturally occurring polypeptide.
  • biologically active refers to the biological activity of a naturally occurring polypeptide as well as to the ability of the polypeptide to exhibit an immunological activity.
  • a polypeptide exhibits an "immunological activity" when antibodies can be generated that are directed against the polypeptide.
  • naturally occurring polypeptide refers to polypeptides produced by cells that have not been genetically engineered and specifically contemplates various polypeptides arising from post-translational modifications of the polypeptide including, but not limited to, acetylation, carboxylation, glycosylation, phosphorylation, lipidation and acylation.
  • mature polypeptide refers to a polypeptide that has been post-translationally modified or that corresponds in primary amino acid sequence to a polypeptide that has been post-translationally modified.
  • a mature polypeptide includes, but is not limited to, a polypeptide which comprises a primary amino acid sequence that has been processed from a "pre-,” “pro-,” or “pre-pro” amino acid sequence; a polypeptide which comprises a primary amino acid sequence corresponding to that of a polypeptide that has been processed from a "pre-,” “pro-,” or “pre-pro” amino acid sequence; a polypeptide that has been post-translationally modified via such modifications as, for example, acetylation, carboxylation, glycosylation, phosphorylation, lipidation and acylation.
  • derivative refers to polypeptides chemically modified by such techniques as ubiquitination, labeling (e.g., with radionucleotides or various enzymes), pegylation (derivatization with polyethylene glycol) and insertion or substitution by chemical synthesis of amino acids such as ornithine, which do not normally occur in human proteins.
  • recombinant variant refers to any polypeptide differing from naturally occurring polypeptides by amino acid insertions, deletions, and substitutions, created using recombinant DNA techniques.
  • amino acid residues may be replaced, added or deleted without abolishing activities of interest, such as cellular trafficking, may be found by comparing the sequence of the particular polypeptide with that of homologous peptides and minimizing the number of amino acid sequence changes made in regions of high homology.
  • amino acid substitutions are the result of replacing one amino acid with another amino acid having similar structural and/or chemical properties, i.e., conservative amino acid replacements.
  • Amino acid substitutions may be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues involved.
  • nonpolar (hydrophobic) amino acids include alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan, and methionine; polar neutral amino acids include glycine, serine, threonine, cysteine, tyrosine, asparagine, and glutamine; positively charged (basic) amino acids include arginine, lysine, and histidine; and negatively charged (acidic) amino acids include aspartic acid and glutamic acid.
  • “Insertions” or “deletions” are typically in the range of about 1 to 5 amino acids.
  • the variation allowed may be experimentally determined by systematically making insertions, deletions, or substitutions of amino acids in a polypeptide molecule using recombinant DNA techniques and assaying the resulting recombinant variants for activity.
  • insertions, deletions or non- conservative alterations can be engineered to produce altered polypeptides.
  • Such alterations can, for example, alter one or more of the biological functions or biochemical characteristics of the polypeptides of the invention.
  • such alterations may change polypeptide characteristics such as ligand-binding affinities, interchain affinities, or degradation/turnover rate.
  • Such alterations can be selected so as to generate polypeptides that are better suited for expression, scale up and the like in the host cells chosen for expression.
  • cysteine residues can be deleted or substituted with another amino acid residue in order to eliminate disulfide bridges.
  • substantially equivalent may refer both to nucleotide and amino acid sequences, for example a mutant sequence, that varies from a reference sequence by one or more substitutions, deletions, or additions, the net effect of which does not result in an adverse functional dissimilarity between the reference and subject sequences.
  • such a substantially equivalent sequence varies from one of those listed herein i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.25 or less.
  • Such a sequence is said to have 75% sequence identity to the listed sequence.
  • Such a substantially equivalent sequence may be routinely identified by applying the foregoing algorithm.
  • a substantially equivalent, e.g., mutant, sequence of the invention varies from a listed sequence by no more than 20%, i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.2 or less.
  • Such a sequence is said to have 80% sequence identity to the listed sequence.
  • Such a substantially equivalent sequence can be routinely identified by applying the foregoing algorithm.
  • a substantially equivalent, e.g., mutant, sequence of the invention varies from a listed sequence by no more than 10%, i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.1 or less.
  • Such a sequence is said to have 90% sequence identity to the listed sequence.
  • Such a substantially equivalent sequence can be routinely identified by applying the foregoing algorithm.
  • a substantially equivalent sequence of the invention varies from a listed sequence by no more than 5%, i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.05 or less.
  • Such a sequence is said to have 95% sequence identity to the listed sequence.
  • Such a substantially equivalent sequence can be routinely identified by applying the foregoing algorithm.
  • a substantially equivalent sequence of the invention varies from a listed sequences by no more than 2%, i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.02 or less.
  • Such a sequence is said to have 98% sequence identity to the listed sequence.
  • Such a substantially equivalent sequence can be routinely identified by applying the foregoing algorithm.
  • amino acid sequences according to the invention generally have at least 95% sequence identity with a listed amino acid sequence, whereas substantially equivalent nucleotide sequence of the invention can have lower percent sequence identities, taking into account, for example, the redundancy or degeneracy of the genetic code.
  • sequences having substantially equivalent biological activity and substantially equivalent expression characteristics are considered substantially equivalent.
  • truncation of the mature sequence e.g., via a mutation which creates a spurious stop codon
  • nucleic acid sequences encoding such substantially equivalent sequences can also routinely be isolated and identified via standard hybridization procedures well known to those of skill in the art.
  • an expression vector may be designed to contain a "signal or leader sequence" which will direct the polypeptide through the membrane of a cell.
  • a signal or leader sequence may be naturally present on the polypeptides of the present invention or provided from heterologous protein sources by recombinant DNA techniques.
  • a polypeptide "fragment,” “portion,” or “segment” is a stretch of amino acid residues of at least about 5 amino acids, often at least about 7 amino acids or about at least about 9 to 13 amino acids, and, in various embodiments, at least about 17, 25, 50, 75, 100, 150, 200, 300, 400 or more amino acids.
  • any polypeptide must have sufficient length to display biologic and/or immunologic activity.
  • Recombinant variants encoding these same or similar polypeptides may be synthesized or selected by making use of the "redundancy" in the genetic code.
  • Various codon substitutions such as the silent changes which produce various restriction sites, may be introduced to optimize cloning into a plasmid or viral vector or expression in a particular prokaryotic or eukaryotic system.
  • Mutations in the polynucleotide sequence may be reflected in the polypeptide or domains of other peptides added to the polypeptide to modify the properties of any part of the polypeptide, to change characteristics such as ligand-binding affinities, interchain affinities, or degradation/turnover rate.
  • Such variant nucleic acids and polypeptides are to be considered part of the present invention.
  • the term "activated" cells as used herein refers to those cells that are engaged in extracellular or intracellular membrane trafficking, including the export of neurosecretory or enzymatic molecules as part of a normal or disease process.
  • purified denotes that the indicated nucleic acid or polypeptide is present in the substantial absence of other biological macromolecules, e.g., polynucleotides, proteins, and the like.
  • the polynucleotide or polypeptide is purified such that it constitutes at least 95% by weight, more preferably at least 99.8% by weight, of the indicated biological macromolecules present (but water, buffers, and other small molecules, especially molecules having a molecular weight of less than 1000 daltons, can be present).
  • isolated refers to a nucleic acid or polypeptide separated from at least one other component (e.g., nucleic acid or polypeptide) present with the nucleic acid or polypeptide in its natural source.
  • the nucleic acid or polypeptide is found in the presence of (if anything) only a solvent, buffer, ion, or other component normally present in a solution of the same.
  • isolated and purified do not encompass nucleic acids or polypeptides present in their natural source.
  • infection refers to the introduction of nucleic acids into a suitable host cell by use of a virus or viral vector.
  • transformation means introducing DNA into a suitable host cell so that the DNA is replicable, either as an extrachromosomal element, or by chromosomal integration.
  • transfection refers to the taking up of an expression vector by a suitable host cell, whether or not any coding sequences are in fact expressed.
  • intermediate fragment means a nucleic acid between about 5 and about 1000 bases in length. In various embodiments, such nucleic acids are between about 10 and about 40 bp in length, or at least about 100, 200, 300, 400, 500, 600, 700, 800 or 900 bp in length.
  • secreted protein refers to a protein that is transported across or through a membrane, including transport as a result of signal sequences in its amino acid sequence when it is expressed in a suitable host cell.
  • Stecreted proteins include without limitation proteins secreted wholly (e.g., soluble proteins) or partially (e.g., receptors, including seven-transmembrane receptors) from the cell in which they are expressed.
  • Stecreted proteins also include without limitation proteins which are transported across the membrane of the endoplasmic reticulum.
  • Fragments of the proteins of the present invention which are capable of exhibiting biological activity are also encompassed by the present invention.
  • Fragments of the protein may be in linear form or they may be cyclized using known methods, for example, as described in H. U. Saragovi, et al., Bio/Technology 10, 773-778 (1992) and in R. S. McDowell, et al., J. Amer. Chem. Soc. 114, 9245- 9253 (1992), both of which are inco ⁇ orated herein by reference.
  • Such fragments may be fused to carrier molecules such as immunoglobulins for many purposes, including increasing the valency of protein binding sites.
  • fragments of the protein may be fused through "linker" sequences to the Fc portion of an immunoglobulin.
  • a bivalent form of the protein such a fusion could be to the Fc portion of an IgG molecule.
  • Other immunoglobulin isotypes may also be used to generate such fusions.
  • a protein-IgM fusion would generate a decavalent form of the protein of the invention.
  • the present invention also provides both full-length and mature forms of the disclosed proteins. The full-length forms of the polypeptides of the invention are identified in the figures and the sequence listing by translation of the nucleotide sequence of each nucleic acid molecule.
  • Mature forms of the polypeptides of the invention can routinely be obtained by expression of the disclosed nucleotides encoding the full-length polypeptides in a suitable mammalian cell or other host cell.
  • the sequence of the mature forms of the polypeptides can also routinely be determined from the amino acid sequence of the full-length polypeptides.
  • the present invention also provides genes corresponding to cDNA sequences disclosed herein.
  • the corresponding genes can be isolated in accordance with known methods using the sequence information disclosed herein. Such methods include the preparation of probes or primers from the disclosed sequence information for identification and/or amplification of genes in appropriate genomic libraries or other sources of genomic materials.
  • the protein of the present invention is membrane-bound (e.g., is a receptor)
  • the present invention also provides for soluble forms of such protein. In such forms part or all of the intracellular and transmembrane domains of the protein are deleted such that the protein is fully secreted from the cell in which it is expressed.
  • the intracellular and transmembrane domains of proteins of the invention can be identified in accordance with known techniques for determination of such domains from sequence information.
  • Species homologs of the disclosed polynucleotides and proteins are also provided by the present invention. Species homologs may be isolated and identified by making suitable probes or primers from the sequences provided herein and screening a suitable nucleic acid source from the desired species. Species homologs can include, but are not limited to human, murine, rat or Drosophila species homologs.
  • the invention also encompasses allelic variants of the disclosed polynucleotides or proteins; that is, naturally-occurring alternative forms of the isolated polynucleotide which also encode proteins which are identical, homologous or related to that encoded by the polynucleotides.
  • Sequences and allelic variant sequences of the invention can include, but are not limited to human, murine, rat and Drosophila sequences.
  • compositions of the present invention include isolated polynucleotides, including recombinant DNA molecules, cloned genes or degenerate variants thereof, especially naturally occurring variants such as allelic variants, novel isolated polypeptides, and antibodies that specifically recognize one or more epitopes present on such polypeptides.
  • One aspect of the present invention pertains to isolated nucleic acid molecules that encode BPIL polypeptides or biologically-active portions thereof.
  • the polynucleotides of the invention include the complement of any of the BPIL polynucleotides.
  • the polynucleotides of the invention also provide polynucleotides that are substantially equivalent to the BPIL polynucleotides.
  • the polynucleotides of this invention also include those polynucleotides that hybridize to SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, 44 under stringent and moderately stringent hybridization conditions.
  • the polynucleotides of the present invention also include those polynucleotides that are 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99% homologous to polynucleotides of SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, 44.
  • a BPIL nucleic acid can encode a mature BPIL polypeptide.
  • a "mature" form of a polypeptide or protein disclosed in the present invention is the product of a naturally occurring polypeptide or precursor form or proprotein.
  • the naturally occurring polypeptide, precursor or proprotein includes, by way of nonlimiting example, the full length gene product, encoded by the corresponding gene. Alternatively, it can be defined as the polypeptide, precursor or proprotein encoded by an open reading frame described herein.
  • the product "mature" form arises, again by way of nonlimiting example, as a result of one or more naturally occurring processing steps as they may take place within the cell, or host cell, in which the gene product arises. Examples of such processing steps leading to a "mature" form of a polypeptide or protein include the cleavage of the N-terminal methionine residue encoded by the initiation codon of an open reading frame, or the proteolytic cleavage of a signal peptide or leader sequence.
  • a mature form arising from a precursor polypeptide or protein that has residues 1 to N, where residue 1 is the N-terminal methionine would have residues 2 through N remaining after removal of the N- terminal methionine.
  • a mature form arising from a precursor polypeptide or protein having residues 1 to N, in which an N-terminal signal sequence from residue 1 to residue M is cleaved would have the residues from residue M+l to residue N remaining.
  • a "mature" form of a polypeptide or protein may arise from a step of post-translational modification other than a proteolytic cleavage event. Such additional processes include, by way of non-limiting example, glycosylation, myristoylation or phosphorylation.
  • a mature polypeptide or protein may result from the operation of only one of these processes, or a combination of any of them.
  • a polynucleotide according to the invention can be joined to any of a variety of other nucleotide sequences by well-established recombinant DNA techniques (see Sambrook, J., et al. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY).
  • Useful nucleotide sequences for joining to polypeptides include an assortment of vectors, e.g., plasmids, cosmids, lambda phage derivatives, phagemids, and the like, that are well known in the art. Accordingly, the invention also provides a vector including a polynucleotide of the invention and a host cell containing the polynucleotide.
  • the vector contains an origin of replication functional in at least one organism, convenient restriction endonuclease sites, and a selectable marker for the host cell.
  • Vectors according to the invention include expression vectors, replication vectors, probe generation vectors, and sequencing vectors.
  • a host cell according to the invention can be a prokaryotic or eukaryotic cell and can be a unicellular organism or part of a multicellular organism.
  • sequences falling within the scope of the present invention are not limited to the specific sequences herein described, but also include allelic variations thereof. Allelic variations can be routinely determined by comparing the sequence provided in SEQ ID NOS:l, 3, 5, 7, 9, 11- 15, 26, 28, 33, 36, 38, 40, and 44, a representative intermediate fragment thereof or a nucleotide sequence at least 99.9% identical to SEQ ID NOS:l, 3, 5, 7, 9, 11-15, 26, 28, 33, 36, 38, 40 or 44 with a sequence from another isolate of the same species. Furthermore, to accommodate codon variability, the invention includes nucleic acid molecules coding for the same amino acid sequences as do the specific ORFs disclosed herein. In other words, in the coding region of an ORF, substitution of one codon for another which encodes the same amino acid is expressly contemplated.
  • the present invention further provides recombinant constructs comprising a nucleic acid having the sequence of SEQ ID NOS:l, 3, 5, 7, 9, 11-15, 26, 28, 33, 36, 38, 40 and 44, or an intermediate fragment thereof, or another of the nucleic acid molecules of the invention.
  • the recombinant constructs of the present invention comprise a vector, such as a plasmid or viral vector, into which a nucleic acid having the sequence of SEQ ID NOS:l, 3, 5, 7, 9, 11-15, 26, 28, 33, 36, 38, 40, or 44 or an intermediate fragment thereof, or another of the nucleic acid molecules of the invention, is inserted, in a forward or reverse orientation.
  • the vector may further comprise regulatory sequences, including for example, a promoter, operably linked to the ORF.
  • a promoter operably linked to the ORF.
  • the vector may further comprise a marker sequence or heterologous ORF operably linked to the EMF or UMF.
  • Bacterial pBs, phagescript, PsiX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene); pTrc99A, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia).
  • Eukaryotic pWLneo, pSV2cat, pOG44, PXTI, pSG (Stratagene) pSVK3, pBPV, pMSG, pSVL (Pharmacia).
  • the isolated polynucleotides of the invention may be operably linked to an expression control sequence such as the pMT2 or pED expression vectors disclosed in Kaufman et al., Nucleic Acids Res. 19, 4485-4490 (1991), in order to produce the protein recombinantly.
  • an expression control sequence such as the pMT2 or pED expression vectors disclosed in Kaufman et al., Nucleic Acids Res. 19, 4485-4490 (1991)
  • Many suitable expression control sequences are known in the art. General methods of expressing recombinant proteins are also known and are exemplified in R. Kaufman, Methods in Enzymology 185, 537-566 (1990).
  • operably linked means that the isolated polynucleotide of the invention and an expression control sequence are situated within a vector or cell in such a way that the protein is expressed by a host cell which has been transformed (transfected) with the ligated polynucleotide/ expression control sequence.
  • Promoter regions can be selected from any desired gene using CAT (chloramphenicol transferase) vectors or other vectors with selectable markers.
  • CAT chloramphenicol transferase
  • Two appropriate vectors are pKK232-8 and pCM7.
  • Particular named bacterial promoters include lad, lacZ, T3, T7, gpt, lambda PR, and trc.
  • Eukaryotic promoters include CMV immediate early, HSV thymidine kinase, early and late SV40, LTRs from retrovirus, and mouse metallothionein-I. Selection of the appropriate vector and promoter is well within the level of ordinary skill in the art. Generally, recombinant expression vectors will include origins of replication and selectable markers permitting transformation of the host cell, e.g., the ampicillin resistance gene of E. coli and S. cerevisiae TRP1 gene, and a promoter derived from a highly-expressed gene to direct transcription of a downstream structural sequence.
  • Such promoters can be derived from operons encoding glycolytic enzymes such as 3-phosphoglycerate kinase (PGK), a-factor, acid phosphatase, or heat shock proteins, among others.
  • PGK 3-phosphoglycerate kinase
  • the heterologous structural sequence is assembled in appropriate phase with translation initiation and termination sequences, and preferably, a leader sequence capable of directing secretion of translated protein into the periplasmic space or extracellular medium.
  • the heterologous sequence can encode a fusion protein including an N- terminal identification peptide imparting desired characteristics, e.g., stabilization or simplified purification of expressed recombinant product.
  • Useful expression vectors for bacterial use are constructed by inserting a structural DNA sequence encoding a desired protein together with suitable translation initiation and termination signals in operable reading phase with a functional promoter.
  • the vector will comprise one or more phenotypic selectable markers and an origin of replication to ensure maintenance of the vector and to, if desirable, provide amplification within the host.
  • Suitable prokaryotic hosts for transformation include E. coli, Bacillus subtilis, Salmonella typhimurium and various species within the genera Pseudomonas, Streptomyces, and Staphylococcus, although others may also be employed as a matter of choice.
  • useful expression vectors for bacterial use can comprise a selectable marker and bacterial origin of replication derived from commercially available plasmids comprising genetic elements of the well known cloning vector pBR322 (ATCC 37017).
  • cloning vector pBR322 ATCC 37017
  • Such commercial vectors include, for example, pKK223-3 (Pharmacia Fine Chemicals, Uppsala, Sweden) and GEM 1 (Promega Biotec, Madison, Wl, USA). These pBR322 "backbone" sections are combined with an appropriate promoter and the structural sequence to be expressed.
  • the selected promoter is induced or derepressed by appropriate means (e.g., temperature shift or chemical induction) and cells are cultured for an additional period.
  • appropriate means e.g., temperature shift or chemical induction
  • Cells are typically harvested by centrifugation, disrupted by physical or chemical means, and the resulting crude extract retained for further purification.

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Abstract

The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the invention comprise amino acid and nucleic acid sequences of novel bactericidal/permeability increasing-like gene and gene products.

Description

METHODS AND COMPOSITIONS RELATING TO BACTERICIDAL/PERMEABILITY INCREASING FACTOR-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES
FIELD OF THE INVENTION
The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins.
BACKGROUND OF THE INVENTION
Bactericidal/permeability increasing factor (BPI) is part of a family of mammalian lipid- binding proteins that include, hpopolysaccharide binding protein (LBP) , cholesteryl ester transfer protein (CETP) and phopholipid transfer protein (PLTP). BPI and LBP are involved in host response to bacterial infections and LPS, CETP and PLTP are lipid transport proteins which regulate the size and composition of LDL and HDL in the bloodstream.
LBP binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex appears to interact with the CD14 receptor and may be responsible for the secretion of alpha-TNF. Similar to LBP, B.PI binds LPS and has a cytotoxic activity on Gram-negative bacteria. CETP is involved in the transfer of insoluble cholesteryl esters in reverse cholesterol transport. PLTP is thought to play a key role in extracellular phospholipid transport and modulation of HDL particles. These proteins are structurally related and share many regions of sequence similarities.
SUMMARY OF THE INVENTION
The compositions of the present invention include novel isolated polypeptides, in particular, novel bactericidal/permeability increasing factor (BPI) - like polypeptides and isolated polynucleotides encoding such polypeptides.
In a further embodiment, the present invention encompasses a method for identifying a composition having bactericidal/permeability increasing factor-like (BPIL) biological activity, the method comprising the steps of: (a) providing a molecular model comprising atomic coordinates defining a three-dimensional shape representative of at least a portion of BPIL; (b) identifying a candidate analog having a three-dimensional shape corresponding to the three-dimensional shape representative of at least a portion of BPIL; and (c) producing the candidate analog identified in step (b). In further embodiments, the compound produced in step (c) has BPIL-like biological activity. In further embodiments, steps (a) and (b) are performed by means of an electronic processor and step (a) comprises storing a representation of at least a portion of the atomic coordinates of BPIL in a computer memory.
Another aspect of the invention is a computer system comprising: (a) a memory comprising atomic coordinates defining at least a portion of BPIL; and (b) a processor in electrical communication with the memory, wherein the processor generates a molecular model having a three-dimensional shape representative of at least a portion of BPIL. In a further aspect, the coordinates are stored on a computer readable diskette. In a further aspect, the molecular model is representative of at least a portion of BPIL binding pocket region.
Another aspect of the invention is a computer comprising a memory containing a three- dimensional representation of BPIL or a portion of BPIL that includes the binding region of BPIL. Another aspect of the invention comprises a machine readable data storage medium, a data storage material coded with machine readable data, the data including the three-dimensional representation, and further wherein the data includes a three-dimensional representation of BPIL or of a portion of BPIL that includes the BPIL binding pocket region. Another aspect of the invention is a machine readable data storage medium, wherein the three-dimensional representation is substantially defined by the atomic coordinates of the amino aids comprising SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45.
Yet another aspect of the invention is a BPIL NH2 or COOH binding pocket amino acid sequence, the amino acid sequence comprising two or more binding pocket residues substantially defined by the atomic coordinates of the amino acid sequences of SEQ ID NO:2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45 which are underlined in the Query sequences as set forth in the Tables with the atomic coordinates of these underlined amino acids being set forth in Table 49-59.
A still further aspect of the invention is a method for identifying a potential modulator of BPIL biological activity, the method comprising the following steps: (1) designing or selecting a potential modulator of BPIL biological activity by utilizing a three-dimensional structure of a BPIL NH2 or COOH binding pocket amino acid sequence comprising two or more pocket binding residues substantially defined by the atomic coordinates of the amino acid sequences of SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45 which are underlined in the Query sequences as set forth in the Tables, with the atomic coordinates of these underlined amino acids being set forth in Tables 49-59; and (2) contacting the potential modulator with BPIL in the presence of a protein which binds to the BPIL superfamily to test the ability of the potential modulator to modulate the interaction between BPIL and the protein which binds to BPIL.
In a further embodiment, the compositions of the present invention include isolated polypeptides at least 80% identical to a polypeptide comprising an amino acid sequence of SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, or 45, as well as fragments, derivatives, analogs, homologs, and naturally occurring allelic variants thereof. In a further embodiment, the polypeptides of the present invention further comprise an NH2 terminal barrel domain, a central β sheet domain, and a COOH-terminal barrel domain. In still a further embodiment, the present polypeptides comprise a binding pocket domain. Additionally, the polypeptides can further comprise a cysteine-cysteine disulfide bond within the NH2 terminal barrel domain. A further embodiment is an isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence of SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, or 45, as well as fragments, derivatives, analogs, homologs, and naturally occurring allelic variants thereof. Another embodiment includes isolated nucleic acid molecules at least 80% identical to the nucleotide sequence of SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, or 44, as well as fragments, derivatives, analogs, and homologs thereof.
Further embodiments include vectors comprising the polynucleotides of the invention and host cells genetically engineered to express the polynucleotides. Additional embodiments include antibodies that bind to the polypeptide of the invention.
Another aspect is a method for determining the presence or amount of the polypeptide of the invention in a sample, the method comprising: (a) introducing the sample to an antibody that binds to the polypeptide; and (b) determining the presence or amount of antibody bound to said polypeptide, thereby determining the presence or amount of polypeptide in the sample.
Yet another aspect is a method for identifying a potential therapeutic agent for use in treatment of a pathology, wherein the pathology is related to aberrant expression or aberrant physiological interactions of the polypeptides of this invention, the method comprising: (a) providing a cell expressing the polypeptide and having a property or function ascribable to the polypeptide; (b) contacting the cell with a composition comprising a candidate substance; and (c) determining whether the substance alters the property or function ascribable to the polypeptide; whereby, if an alteration observed in the presence of the substance is not observed when the cell is contacted with a composition devoid of the substance, the substance is identified as a potential therapeutic agent.
Further aspects include a pharmaceutical composition comprising the polypeptides of the invention and a pharmaceutically acceptable carrier, and a pharmaceutical composition comprising the nucleic acid molecules of the invention and a pharmaceutically acceptable carrier.
BRIEF DESCRIPTION OF THE FIGURES
Figure 1. Hydrophobicity predictions for the amino acid sequence of BPIL 196-1 (SEQ ID NO:2) and BPIL196-2 (SEQ ID NO:4). Predictions were made using the Topred-11 1.1 program (Claros, M.G. & Von Hejine, G., 1994, Comput. Appl. Biosci. 10:685-686; putative setting=0.5; certain setting=1.0).
Figure 2. Hydrophobicity predictions for the amino acid sequence of BPIL232-1 (SEQ ID NO:6) and BPIL232-2 (SEQ ID NO:8). Predictions were made using the Topred-II 1.1 program (Claros, M.G. & Von Hejine, G., 1994, Comput. Appl. Biosci. 10:685-686; putative setting=0.5; certain setting=1.0).
Figure 3. Comparison of the hydrophobicity predictions for the amino acid sequence of BPIL325-1 (SEQ ID NO: 10). Predictions were made using the Topred-II 1.1 program (Claros, M.G. & Von Hejine, G., 1994, Comput. Appl. Biosci. 10:685-686; putative setting=0.5; certain setting=1.0).
Figure 4. is an illustration of the ribbon diagrams of BPIL 196-1 predicted three dimensional structure.
Figure 5. is an illustration of the ribbon diagrams of BPIL 196-2 predicted three dimensional structure Figure 6. is an illustration of the ribbon diagrams of BPIL 232-1 predicted three dimensional structure.
Figure 7. is an illustration of the ribbon diagrams of BPIL 232-2 predicted three dimensional stmcture
Figure 8. is an illustration of the ribbon diagrams of BPIL 232-3 predicted three dimensional structure.
Figure 9. is an illustration of the ribbon diagrams of BPIL 232-4 predicted three dimensional structure
Figure 10. is an illustration of the ribbon diagrams of BPIL 232-5 predicted three dimensional structure.
Figure 11. is an illustration of the ribbon diagrams of BPIL 232-6 predicted three dimensional structure.
Figure 12. is an illustration of the ribbon diagrams of BPIL 325-3 predicted three dimensional structure
Figure 13. is an illustration of the ribbon diagrams of BPIL 325-4 predicted three dimensional structure.
DETAILED DESCRIPTION OF THE INVENTION The present invention provides novel bactericidal/permeability-increasing protein like (BPIL) nucleotides and polypeptides encoded thereby. Bactericidal/permeability-increasing protein (BPI) belongs to a superfamily of functionally related proteins that include hpopolysaccharide binding protein (LBP), cholesteryl ester transfer protein (CETP) and phopholipid transfer protein (PLTP). Included in the invention are the novel nucleic acid sequences and their polypeptides. The sequences are collectively referred to as "BPILX nucleic acids" or "BPILX polynucleotides" and the corresponding encoded polypeptides are referred to as "BPILX polypeptides" or "BPILX proteins." Unless indicated otherwise, "BPILX " is meant to refer to any of the novel sequences disclosed herein. Table 1 provides a summary of the BPILX nucleic acids and their encoded polypeptides.
Table 1 Sequences and Corresponding SEQ ID Numbers
BPILX Nucleic Polypeptide Predicted Start Nucleotide Amino ORF Expression Data
Assignment Acid SEQ SEQ ID NO Signal Codon Length Acid SEQ ID
ID NO Sequence (ORF) Length NO
BPIL 196-1 1 2 20 aa 80 1373 458 11 Adult bone marrow, cerebellum, liver (80-139) lung, salivary glands, trachea, tonsil, fetal heart, liver, lung spleen
BPIL 196-2 3 4 20 aa 80 1373 458 12 Adult bone marrow, cerebellum, liver (80-139) lung, salivary glands, trachea; tonsil, fetal heart, liver, lung spleen
BPIL 232-1 5 6 23 aa 94 1427 476 13 fetal skin (94-162)
BPIL 232-2 7 8 23 aa 94 1427 476 14 fetal skin (94-162)
BPIL 325-1 9 10 ND ND 327 109 15 adult trachea and tonsil
BPIL 232-3 26 27 23 aa 1518 507 30 Fetal skin and fetal lymphocytes
BPIL 232-4 28 29 23 aa 94 1367 455 31 Fetal skin and fetal lymphocytes
BPIL 325-2 33 32 2 450 150 34 Tonsil
BPIL 325-3 36 35 16 aa 1 1362 454 37 Tonsil
BPIL 232-5 38 39 23 aa 1518 507 42 Fetal skm and fetal lymphocytes
BPIL 232-6 40 41 23 aa 94 1518 407 43 Fetal skin and fetal lymphocytes
BPIL 325-4 44 45 16 aa 1 1359 453 44 Tonsil
BPILX nucleic acids, and their encoded polypeptides, according to the invention are useful in a variety of applications and contexts. For example, BPILX nucleic acids and polypeptides can be used to identify proteins that are members of the bactericidal/permeability-increasing protein superfamily. The BPILX nucleic acids and polypeptides can also be used to screen for molecules which inhibit or enhance BPILX activity or function. Specifically, the nucleic acids and polypeptides according to the invention may be used as targets for the identification of small molecules that modulate, e.g., antibiotics, cytokine production, immune function. These molecules can be used to treat, e.g., bacteremia, endotoxemia, inflammatory bowel disease, cystic fibrosis, gingivitis, peridontitis, septic shock, cystic fibrosis, meningoccemia or hemorrhagic trauma in mammals, e.g. humans.
In addition, various BPILX nucleic acids and polypeptides according to the invention are useful, inter alia, as novel members of the protein families according to the presence of domains and sequence relatedness to previously described proteins. For example, the BPILX nucleic acids and their encoded polypeptides include secondary structural motifs that are characteristic of proteins belonging to the bactericidal/permeability-increasing protein superfamily. Additionally, the BPILX nucleic acids and their encoded polypeptides include tertiary structural motifs similar to human bactericidal/permeability-increasing protein. The molecular models of the BPILX polypeptides according to the invention demonstrate that the BPILX polypeptides form a boomerang-shaped molecule with two domains (an amino and carboxy terminal) that are connected by a proline rich linker which is consistent with other members of the bactericidal/permeability- increasing protein superfamily. Specifically, the amino and carboxy domains each form a barrel containing a short α-helix, a five-stranded antiparallel β-sheet and a long helix. The barrels are connected by a central β-sheet. A single disulfide bond anchors the long helix and the final strand of the β-sheet within the amino terminal barrel. Proteins belonging to this family of proteins have been implicated in bacteremia and endotoxemia. Thus, the BPILX nucleic acids and polypeptides, antibodies and related compounds according to the invention will be useful in therapeutic applications implicated in, e.g., septic shock, cystic fibrosis, inflamatory bowel disease, gingivitis, periodontitis, meningoccemia or hemorrhagic trauma. In addition, BPILX nucleic acids, polypeptides, antibodies and related compounds of the invention may be used to modulate, e.g., inflammation, immune function and cytokine production. Tissue expression analysis as described in EXAMPLE 9 below indicates BPILX nucleic acids are highly expressed in diseased tonsils, suggesting a potential therapeutic application of BPILX nucleic acids and polypeptides as diagnostic markers for tonsil disease, such as for example, tonsillitis, and tonsil Hodgkin disease. In addition, BPILX nucleic acids are also expressed in a variety of cell types, e.g, adult bone marrow, fetal skin, fetal lymphocytes and adult trachea. Accordingly, the BPILX nucleic acids, polypeptides and antibodies according to the invention may be used in tissue typing analysis to identify these cell types.
Additional utilities for BPILX nucleic acids and polypeptides according to the invention are disclosed herein. BPIL-196 Genes
Two novel BPIL-196 genes were identified, BPIL 196-1 and BPIL 196-2 (hereinafter collectively referred to as "BPIL-196"). A BPIL- 196-1 nucleic acid and its encoded polypeptide include the sequences shown in Table 2, whereas a BPIL- 196-2 nucleic acid and its encoded polypeptide include the sequences shown in Table 3. The disclosed BPIL-196-1 nucleic acid (SEQ ID NO: 1) contains a 1373 nucleotide open reading frame (ORF, SEQ ID NO: 11) that begins with an ATG initiation codon at nucleotides 80- 82. The representative ORF includes a 458 amino acid polypeptide (SEQ ID NO: 2). The program Topred-II, predicts a signal peptidase cleavage site at approximately between amino acids 20 and 21. One of skill in the art could confirm this cleavage site by expressing the mature protein. The disclosed BPIL-196-2 nucleic acid (SEQ ID NO: 3) contains a 1373 nucleotide open reading frame (ORF, SEQ ID NO: 12) that begins with an ATG initiation codon at nucleotides 80- 82. The representative ORF includes a 458 amino acid polypeptide (SEQ ID NO: 4). The program Topred-II, predicts a signal peptidase cleavage site at approximately between amino acids 20 and 21. One of skill in the art could confirm this cleavage site by expressing the mature protein. Analysis of the BPIL-196-1 and BPIL-196-2 sequences identified a single nucleotide polymorphism at nucleotide 609. Specifically, nucleotide 609 of SEQ ID NO: 1 is a cytosine whereas the nucleotide 609 of SEQ ID NO: 2 is thymine. This difference results in a change in amino acid residue 177 from a threonine in BPIL-196-1 to an isoleucine in BPIL 196-2.
Table 2: Sequence of BPIL 196-1
2A: Nucleic Acid and Polypeptide Sequence gctaccctgg ggctgatagt tcacctgtct caggaaccac ctgagcccac agatcctgtg 60 ggcagcggcc agggcagcc atg get tgg gca agt agg ctg ggc ctg ctg ctg 112
Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu
1 5 10 gca ctg ctg ctg ccc gtg gtc ggt gcc tec acg cca ggc ace gtg gtc 160
Ala Leu Leu Leu Pro Val Val Gly Ala Ser Thr Pro Gly Thr Val Val
15 ' 20 25 cga etc aac aag gca gca ttg age tac gtg tct gaa att ggg aaa gcc 208
Arg Leu Asn Lys Ala Ala Leu Ser Tyr Val Ser Glu He Gly Lys Ala
30 35 0 cct etc cag egg gcc ctg cag gtc act gtc cct cat ttc ctg gac tgg 256 Pro Leu Gin Arg Ala Leu Gin Val Thr Val Pro His Phe Leu Asp Trp
45 50 55 agt gga gag gcg ctt cag ccc ace agg ate egg att ctg aat gtc cat 304
Ser Gly Glu Ala Leu Gin Pro Thr Arg He Arg He Leu Asn Val His 60 65 70 75 gtg ccc cgc etc cac ctg aaa ttc att get ggt ttc gga gtg cgc ctg 352
Val Pro Arg Leu His Leu Lys Phe He Ala Gly Phe Gly Val Arg Leu
80 85 90 ctg gca gca get aat ttt act ttc aag gtc ttt cgc gcc cca gag ccc 400
Leu Ala Ala Ala Asn Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro
95 100 105 ctg gag ctg acg ctg cct gtg gaa ctg ctg get gac ace cgc gtg ace 448
Leu Glu Leu Thr Leu Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr
110 115 120 cag age tec ate agg ace cct gtg gtc age ate tct gcc tgc tct tta 496 Gin Ser Ser He Arg Thr Pro Val Val Ser He Ser Ala Cys Ser Leu
125 130 135 ttc teg ggc cac gcc aac gag ttt gat ggc agt aac age ace tec cac 544
Phe Ser Gly His Ala Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His 140 145 150 155 gcg ctg ctg gtc ctg gtg cag aag cac att aaa get gtc ttg agt aac 592
Ala Leu Leu Val Leu Val Gin Lys His He Lys Ala Val Leu Ser Asn
160 165 170 aag ctg tgc ctg age ace tec aac ctg gtg cag ggt gtc aat gtc cac 640
Lys Leu Cys Leu Ser Thr Ser Asn Leu Val Gin Gly Val Asn Val His
175 180 185 ctg ggc ace tta att ggc etc aac ccc gtg ggt cct gag tec cag ate 688
Leu Gly Thr Leu He Gly Leu Asn Pro Val Gly Pro Glu Ser Gin He
190 195 200 cgc tat tec atg gtc agt gtg ccc act gtc ace agt gac tac att tec 736 Arg Tyr Ser Met Val Ser Val Pro Thr Val Thr Ser Asp Tyr He Ser
205 210 215 ctg gaa gtc aat get gtt etc ttc ctg ctg ggc aag ccc ate ate ctg 784 Leu Glu Val Asn Ala Val Leu Phe Leu Leu Gly Lys Pro He He Leu 220 225 230 235 ccc acg gat gcc ace cct ttt gtg ttg cca agg cat gtg ggt ace gag 832 Pro Thr Asp Ala Thr Pro Phe Val Leu Pro Arg His Val Gly Thr Glu 240 245 250 ggc tec atg gcc ace gtg ggc etc tec cag cag ctg ttt gac tct gcg 880 Gly Ser Met Ala Thr Val Gly Leu Ser Gin Gin Leu Phe Asp Ser Ala 255 260 265 etc ctg ctg ctg cag aag gcc ggt gcc etc aac ctg gac ate aca ggg 928 Leu Leu Leu Leu Gin Lys Ala Gly Ala Leu Asn Leu Asp He Thr Gly 270 275 280 cag ctg agg teg gat gac aac ctg ctg aac ace tct get ctg ggc egg 976 Gin Leu Arg Ser Asp Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg 285 290 295 etc ate ccg gag gtg gcc cgc cag ttt ccc gag ccc atg cct gtg gtg 1024 Leu He Pro Glu Val Ala Arg Gin Phe Pro Glu Pro Met Pro Val Val 300 305 310 315 etc aag gtg egg ctg ggt gcc aca cct gtg gcc atg etc cac aca aac 1072 Leu Lys Val Arg Leu Gly Ala Thr Pro Val Ala Met Leu His Thr Asn 320 325 330 aac gcc ace ctg egg ctg cag ccc ttc gtg gag gtc ctg gcc aca gcc 1120 Asn Ala Thr Leu Arg Leu Gin Pro Phe Val Glu Val Leu Ala Thr Ala 335 340 345 tec aac teg get ttc cag tec etc ttc tec ctg gat gtg gta gtg aac 1168 Ser Asn Ser Ala Phe Gin Ser Leu Phe Ser Leu Asp Val Val Val Asn 350 355 360 ttg aga etc cag etc tct gtg tec aag gtg aag ctt cag ggg ace acg 1216 Leu Arg Leu Gin Leu Ser Val Ser Lys Val Lys Leu Gin Gly Thr Thr 365 370 375 tct gtg ctg ggg gat gtc cag etc acg gtg gcc tec tec aac gtg ggc 1264 Ser Val Leu Gly Asp Val Gin Leu Thr Val Ala Ser Ser Asn Val Gly 380 385 390 395 ttc att gat aca gat cag gtg cgc aca ctg atg ggc ace gtt ttt gag 1312 Phe He Asp Thr Asp Gin Val Arg Thr Leu Met Gly Thr Val Phe Glu 400 405 410 aag ccc ctg ctg gac cat etc aat get etc ttg gcc atg gga att gcc 1360 Lys Pro Leu Leu Asp His Leu Asn Ala Leu Leu Ala Met Gly He Ala 415 420 425 etc cct ggt gtg gtc aac etc cac tat gtc gcc cct gag ate ttt gtc 1408 Leu Pro Gly Val Val Asn Leu His Tyr Val Ala Pro Glu He Phe Val 430 435 440 tat gag ggc tac gtg gtg ata tec agt gga etc ttc tac cag age 1453 Tyr Glu Gly Tyr Val Val He Ser Ser Gly Leu Phe Tyr Gin Ser (SEQ ID NO: 2) 445 450 455 tgaggcaaga ccactgggag gcctgagagt gggccagctc gctgctcagg cgaatttctc 1513 atttcaagcc actggggaaa ctgaggcaaa accatactta gtcatcacea acaagetgga 1573 ctgcttagct gggctgtttt atcttccctg agtgcctggg tctccctccc tcacttctgc 1633 cctttccctt cetccteetc ttctcctcce tcttceetca tctccccect eettcctctg 1693 ccccacccca gcggggagca gactgctcct ccaggctgta tagacctgcc ctcttgcatt 1753 aaacaacttc tcttgagctg caactttcaa aaaaaaaaaa a (SEQ ID NO: 1) 1794
2B: Open Reading Frame (ORF) atg get tgg gca agt agg ctg ggc ctg ctg ctg gca ctg ctg ctg ccc 48 Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu Ala Leu Leu Leu Pro 1 5 10 15 gtg gtc ggt gcc tec acg cca ggc ace gtg gtc cga etc aac aag gca 96
Val Val Gly Ala Ser Thr Pro Gly Thr Val Val Arg Leu Asn Lys Ala
20 25 30 gca ttg age tac gtg tct gaa att ggg aaa gcc cct etc cag egg gcc 144
Ala Leu Ser Tyr Val Ser Glu He Gly Lys Ala Pro Leu Gin Arg Ala 35 40 45 ctg cag gtc act gtc cct cat ttc ctg gac tgg agt gga gag gcg ctt 192 Leu Gin Val Thr Val Pro His Phe Leu Asp Trp Ser Gly Glu Ala Leu 50 55 60 cag ccc ace agg ate egg att ctg aat gtc cat gtg ccc cgc etc cac 240 Gin Pro Thr Arg He Arg He Leu Asn Val His Val Pro Arg Leu His
65 70 75 80 ctg aaa ttc att get ggt ttc gga gtg cgc ctg ctg gca gca get aat 288 Leu Lys Phe He Ala Gly Phe Gly Val Arg Leu Leu Ala Ala Ala Asn 85 90 95 ttt act ttc aag gtc ttt cgc gcc cca gag ccc ctg gag ctg acg ctg 336 Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro Leu Glu Leu Thr Leu 100 105 110 cct gtg gaa ctg ctg get gac ace cgc gtg ace cag age tec ate agg 384 Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr Gin Ser Ser He Arg 115 120 125 ace cct gtg gtc age ate tct gcc tgc tct tta ttc teg ggc cac gcc 432 Thr Pro Val Val Ser He Ser Ala Cys Ser Leu Phe Ser Gly His Ala 130 135 140 aac gag ttt gat ggc agt aac age ace tec cac gcg ctg ctg gtc ctg 480 Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His Ala Leu Leu Val Leu
145 150 155 160 gtg cag aag cac att aaa get gtc ttg agt aac aag ctg tgc ctg age 528 Val Gin Lys His He Lys Ala Val Leu Ser Asn Lys Leu Cys Leu Ser 165 170 175 ace tec aac ctg gtg cag ggt gtc aat gtc cac ctg ggc ace tta att 576
Thr Ser Asn Leu Val Gin Gly Val Asn Val His Leu Gly Thr Leu He
180 185 190 ggc etc aac ccc gtg ggt cct gag tec cag ate cgc tat tec atg gtc 624
Gly Leu Asn Pro Val Gly Pro Glu Ser Gin He Arg Tyr Ser Met Val 195 200 205 agt gtg ccc act gtc ace agt gac tac att tec ctg gaa gtc aat get 672
Ser Val Pro Thr Val Thr Ser Asp Tyr He Ser Leu Glu Val Asn Ala 210 215 220 gtt etc ttc ctg ctg ggc aag ccc ate ate ctg ccc acg gat gcc ace 720 Val Leu Phe Leu Leu Gly Lys Pro He He Leu Pro Thr Asp Ala Thr 225 230 235 240 cct ttt gtg ttg cca agg cat gtg ggt ace gag ggc tec atg gcc ace 768
Pro Phe Val Leu Pro Arg His Val Gly Thr Glu Gly Ser Met Ala Thr 245 250 255 gtg ggc etc tec cag cag ctg ttt gac tct gcg etc ctg ctg ctg cag 816
Val Gly Leu Ser Gin Gin Leu Phe Asp Ser Ala Leu Leu Leu Leu Gin
260 265 270 aag gcc ggt gcc etc aac ctg gac ate aca ggg cag ctg agg teg gat 864
Lys Ala Gly Ala Leu Asn Leu Asp He Thr Gly Gin Leu Arg Ser Asp 275 280 285 gac aac ctg ctg aac ace tct get ctg ggc egg etc ate ccg gag gtg 912
Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg Leu lie Pro Glu Val 290 295 300 gcc cgc cag ttt ccc gag ccc atg cct gtg gtg etc aag gtg egg ctg 960 Ala Arg Gin Phe Pro Glu Pro Met Pro Val Val Leu Lys Val Arg Leu 305 310 315 320 ggt gcc aca cct gtg gcc atg etc cac aca aac aac gcc ace ctg egg 1008
Gly Ala Thr Pro Val Ala Met Leu His Thr Asn Asn Ala Thr Leu Arg 325 330 335 ctg cag ccc ttc gtg gag gtc ctg gcc aca gcc tec aac teg get ttc 1056
Leu Gin Pro Phe Val Glu Val Leu Ala Thr Ala Ser Asn Ser Ala Phe
340 345 350 cag tec etc ttc tec ctg gat gtg gta gtg aac ttg aga etc cag etc 1104
Gin Ser Leu Phe Ser Leu Asp Val Val Val Asn Leu Arg Leu Gin Leu 355 360 365 tct gtg tec aag gtg aag ctt cag ggg ace acg tct gtg ctg ggg gat 1152
Ser Val Ser Lys Val Lys Leu Gin Gly Thr Thr Ser Val Leu Gly Asp 370 375 380 gtc cag etc acg gtg gcc tec tec aac gtg ggc ttc att gat aca gat 1200 Val Gin Leu Thr Val Ala Ser Ser Asn Val Gly Phe He Asp Thr Asp 385 390 395 400 cag gtg cgc aca ctg atg ggc ace gtt ttt gag aag ccc ctg ctg gac 1248 Gin Val Arg Thr Leu Met Gly Thr Val Phe Glu Lys Pro Leu Leu Asp 405 410 415 cat etc aat get etc ttg gcc atg gga att gcc etc cct ggt gtg gtc 1296 His Leu Asn Ala Leu Leu Ala Met Gly He Ala Leu Pro Gly Val Val 420 425 430 aac etc cac tat gtc gcc cct gag ate ttt gtc tat gag ggc tac gtg 1344 Asn Leu His Tyr Val Ala Pro Glu He Phe Val Tyr Glu Gly Tyr Val 435 440 445 gtg ata tec agt gga etc ttc tac cag age (SEQ ID NO: 11) 1374
Val He Ser Ser Gly Leu Phe Tyr Gin Ser (SEQ ID NO : 2) 450 455
Table 3; Sequence ofBPIL 196-2
3A: Nucleic Acid and Polypeptide Sequences gctaccctgg ggctgatagt tcacctgtct caggaaccac ctgagcccac agatcctgtg 60 ggcagcggcc agggcagcc atg get tgg gca agt agg ctg ggc ctg ctg ctg 112
Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu 1 5 10 gca ctg ctg ctg ccc gtg gtc ggt gcc tec acg cca ggc ace gtg gtc 160 Ala Leu Leu Leu Pro Val Val Gly Ala Ser Thr Pro Gly Thr Val Val 15 20 25 cga etc aac aag gca gca ttg age tac gtg tct gaa att ggg aaa gcc 208 Arg Leu Asn Lys Ala Ala Leu Ser Tyr Val Ser Glu He Gly Lys Ala 30 35 40 cct etc cag egg gcc ctg cag gtc act gtc cct cat ttc ctg gac tgg 256 Pro Leu Gin Arg Ala Leu Gin Val Thr Val Pro His Phe Leu Asp Trp 45 50 55 agt gga gag gcg ctt cag ccc ace agg ate egg att ctg aat gtc cat 304
Ser Gly Glu Ala Leu Gin Pro Thr Arg He Arg He Leu Asn Val His
60 65 70 75 gtg ccc cgc etc cac ctg aaa ttc att get ggt ttc gga gtg cgc ctg 352
Val Pro Arg Leu His Leu Lys Phe He Ala Gly Phe Gly Val Arg Leu
80 85 90 ctg gca gca get aat ttt act ttc aag gtc ttt cgc gcc cca gag ccc 400 Leu Ala Ala Ala Asn Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro 95 100 105 ctg gag ctg acg ctg cct gtg gaa ctg ctg get gac ace cgc gtg ace 448 Leu Glu Leu Thr Leu Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr 110 115 120 cag age tec ate agg ace cct gtg gtc age ate tct gcc tgc tct tta 496 Gin Ser Ser He Arg Thr Pro Val Val Ser He Ser Ala Cys Ser Leu 125 130 135 ttc teg ggc cac gcc aac gag ttt gat ggc agt aac age ace tec cac 544 Phe Ser Gly His Ala Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His 140 145 150 155 gcg ctg ctg gtc ctg gtg cag aag cac att aaa get gtc ttg agt aac 592 Ala Leu Leu Val Leu Val Gin Lys His He Lys Ala Val Leu Ser Asn 160 165 170 aag ctg tgc ctg age ate tec aac ctg gtg cag ggt gtc aat gtc cac 640 Lys Leu Cys Leu Ser He Ser Asn Leu Val Gin Gly Val Asn Val His 175 180 185 ctg ggc ace tta att ggc etc aac ccc gtg ggt cct gag tec cag ate 688 Leu Gly Thr Leu He Gly Leu Asn Pro Val Gly Pro Glu Ser Gin He 190 195 200 cgc tat tec atg gtc agt gtg ccc act gtc ace agt gac tac att tec 736 Arg Tyr Ser Met Val Ser Val Pro Thr Val Thr Ser Asp Tyr He Ser 205 210 215 ctg gaa gtc aat get gtt etc ttc ctg ctg ggc aag ccc ate ate ctg 784 Leu Glu Val Asn Ala Val Leu Phe Leu Leu Gly Lys Pro He He Leu 220 225 230 235 ccc acg gat gcc ace cct ttt gtg ttg cca agg cat gtg ggt ace gag 832 Pro Thr Asp Ala Thr Pro Phe Val Leu Pro Arg His Val Gly Thr Glu 240 245 250 ggc tec atg gcc ace gtg ggc etc tec cag cag ctg ttt gac tct gcg 880 Gly Ser Met Ala Thr Val Gly Leu Ser Gin Gin Leu Phe Asp Ser Ala 255 260 265 etc ctg ctg ctg cag aag gcc ggt gcc etc aac ctg gac ate aca ggg 928 Leu Leu Leu Leu Gin Lys Ala Gly Ala Leu Asn Leu Asp He Thr Gly 270 275 280 cag ctg agg teg gat gac aac ctg ctg aac ace tct get ctg ggc egg 976 Gin Leu Arg Ser Asp Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg 285 290 295 etc ate ccg gag gtg gcc cgc cag ttt ccc gag ccc atg cct gtg gtg 1024 Leu He Pro Glu Val Ala Arg Gin Phe Pro Glu Pro Met Pro Val Val 300 305 310 315 etc aag gtg egg ctg ggt gcc aca cct gtg gcc atg etc cac aca aac 1072 Leu Lys Val Arg Leu Gly Ala Thr Pro Val Ala Met Leu His Thr Asn 320 325 330 aac gcc ace ctg egg ctg cag ccc ttc gtg gag gtc ctg gcc aca gcc 1120 Asn Ala Thr Leu Arg Leu Gin Pro Phe Val Glu Val Leu Ala Thr Ala 335 340 345 tec aac teg get ttc cag tec etc ttc tec ctg gat gtg gta gtg aac 1168 Ser Asn Ser Ala Phe Gin Ser Leu Phe Ser Leu Asp Val Val Val Asn 350 355 360 ttg aga etc cag etc tct gtg tec aag gtg aag ctt cag ggg ace acg 1216 Leu Arg Leu Gin Leu Ser Val Ser Lys Val Lys Leu Gin Gly Thr Thr 365 370 375 tct gtg ctg ggg gat gtc cag etc acg gtg gcc tec tec aac gtg ggc 1264 Ser Val Leu Gly Asp Val Gin Leu Thr Val Ala Ser Ser Asn Val Gly 380 385 390 395 ttc att gat aca gat cag gtg cgc aca ctg atg ggc ace gtt ttt gag 1312 Phe He Asp Thr Asp Gin Val Arg Thr Leu Met Gly Thr Val Phe Glu 400 405 410 aag ccc ctg ctg gac cat etc aat get etc ttg gcc atg gga att gcc 1360 Lys Pro Leu Leu Asp His Leu Asn Ala Leu Leu Ala Met Gly He Ala 415 420 425 etc cct ggt gtg gtc aac etc cac tat gtc gcc cct gag ate ttt gtc 1408 Leu Pro Gly Val Val Asn Leu His Tyr Val Ala Pro Glu He Phe Val 430 435 440 tat gag ggc tac gtg gtg ata tec agt gga etc ttc tac cag age 1453 Tyr Glu Gly Tyr Val Val He Ser Ser Gly Leu Phe Tyr Gin Ser (SEQ ID NO : 4) 445 450 455 tgaggcaaga ccactgggag gcctgagagt gggccagctc gctgctcagg cgaatttctc 1513 atttcaagcc actggggaaa ctgaggcaaa accatactta gtcatcacea acaagetgga 1573 ctgcttagct gggctgtttt atcttccctg agtgcctggg tctccctccc tcacttctgc 1633 cctttccctt cetccteetc ttctcctcce tcttceetca tctccccect eettcctctg 1693 ccccacccca gcggggagca gactgctcct ccaggctgta tagacctgcc ctcttgcatt 1753 aaacaacttc tcttgagctg caactttcaa aaaaaaaaaa a (SEQ ID NO: 3) 1794
3B: Open reading Frame atg get tgg gca agt agg ctg ggc ctg ctg ctg gca ctg ctg ctg ccc 48 Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu Ala Leu Leu Leu P Prro 1 5 10 15 gtg gtc ggt gcc tec acg cca ggc ace gtg gtc cga etc aac aag gca 96 Val Val Gly Ala Ser Thr Pro Gly Thr Val Val Arg Leu Asn Lys Ala
20 25 30 gca ttg age tac gtg tct gaa att ggg aaa gcc cct etc cag egg gcc 144 Ala Leu Ser Tyr Val Ser Glu He Gly Lys Ala Pro Leu Gin Arg Ala 35 40 45 ctg cag gtc act gtc cct cat ttc ctg gac tgg agt gga gag gcg ctt 192 Leu Gin Val Thr Val Pro His Phe Leu Asp Trp Ser Gly Glu Ala Leu 50 55 60 cag ccc ace agg ate egg att ctg aat gtc cat gtg ccc cgc etc cac 240 Gin Pro Thr Arg He Arg He Leu Asn Val His Val Pro Arg Leu His 65 70 75 80 ctg aaa ttc att get ggt ttc gga gtg cgc ctg ctg gca gca get aat 288 Leu Lys Phe He Ala Gly Phe Gly Val Arg Leu Leu Ala Ala Ala Asn 85 90 95 ttt act ttc aag gtc ttt cgc gcc cca gag ccc ctg gag ctg acg ctg 336 Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro Leu Glu Leu Thr Leu 100 105 110 cct gtg gaa ctg ctg get gac ace cgc gtg ace cag age tec ate agg 384 Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr Gin Ser Ser He Arg 115 120 125 ace cct gtg gtc age ate tct gcc tgc tct tta ttc teg ggc cac gcc 432 Thr Pro Val Val Ser He Ser Ala Cys Ser Leu Phe Ser Gly His Ala 130 135 140 aac gag ttt gat ggc agt aac age ace tec cac gcg ctg ctg gtc ctg 480 Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His Ala Leu Leu Val Leu 145 150 155 160 gtg cag aag cac att aaa get gtc ttg agt aac aag ctg tgc ctg age 528 Val Gin Lys His He Lys Ala Val Leu Ser Asn Lys Leu Cys Leu Ser
165 170 175 ate tec aac ctg gtg cag ggt gtc aat gtc cac ctg ggc ace tta att 576 He Ser Asn Leu Val Gin Gly Val Asn Val His Leu Gly Thr Leu He 180 185 190 ggc etc aac ccc gtg ggt cct gag tec cag ate cgc tat tec atg gtc 624 Gly Leu Asn Pro Val Gly Pro Glu Ser Gin He Arg Tyr Ser Met Val 195 200 205 agt gtg ccc act gtc ace agt gac tac att tec ctg gaa gtc aat get 672 Ser Val Pro Thr Val Thr Ser Asp Tyr He Ser Leu Glu Val Asn Ala 210 215 220 gtt etc ttc ctg ctg ggc aag ccc ate ate ctg ccc acg gat gcc ace 720 Val Leu Phe Leu Leu Gly Lys Pro He He Leu Pro Thr Asp Ala Thr 225 230 235 240 cct ttt gtg ttg cca agg cat gtg ggt ace gag ggc tec atg gcc ace 768 Pro Phe Val Leu Pro Arg His Val Gly Thr Glu Gly Ser Met Ala Thr
245 250 255 gtg ggc etc tec cag cag ctg ttt gac tct gcg etc ctg ctg ctg cag 816 Val Gly Leu Ser Gin Gin Leu Phe Asp Ser Ala Leu Leu Leu Leu Gin 260 265 270 aag gcc ggt gcc etc aac ctg gac ate aca ggg cag ctg agg teg gat 864 Lys Ala Gly Ala Leu Asn Leu Asp He Thr Gly Gin Leu Arg Ser Asp 275 280 285 gac aac ctg ctg aac ace tct get ctg ggc egg etc ate ccg gag gtg 912
Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg Leu He Pro Glu Val 290 295 300 gcc cgc cag ttt ccc gag ccc atg cct gtg gtg etc aag gtg egg ctg 960 Ala Arg Gin Phe Pro Glu Pro Met Pro Val Val Leu Lys Val Arg Leu 305 310 315 320 ggt gcc aca, cct gtg gcc atg etc cac aca aac aac gcc ace ctg egg 1008
Gly Ala Thr Pro Val Ala Met Leu His Thr Asn Asn Ala Thr Leu Arg 325 330 335 ctg cag ccc ttc gtg gag gtc ctg gcc aca gcc tec aac teg get ttc 1056
Leu Gin Pro Phe Val Glu Val Leu Ala Thr Ala Ser Asn Ser Ala Phe 340 345 350 cag tec etc ttc tec ctg gat gtg gta gtg aac ttg aga etc cag etc 1104
Gin Ser Leu Phe Ser Leu Asp Val Val Val Asn Leu Arg Leu Gin Leu 355 360 365 tct gtg tec aag gtg aag ctt cag ggg ace acg tct gtg ctg ggg gat 1152 Ser Val Ser Lys Val Lys Leu Gin Gly Thr Thr Ser Val Leu Gly Asp
370 375 380 gtc cag etc acg gtg gcc tec tec aac gtg ggc ttc att gat aca gat 1200
Val Gin Leu Thr Val Ala Ser Ser Asn Val Gly Phe He Asp Thr Asp 385 390 395 400 cag gtg cgc aca ctg atg ggc ace gtt ttt gag aag ccc ctg ctg gac 1248
Gin Val Arg Thr Leu Met Gly Thr Val Phe Glu Lys Pro Leu Leu Asp 405 410 415 cat etc aat get etc ttg gcc atg gga att gcc etc cct ggt gtg gtc 1296
His Leu Asn Ala Leu Leu Ala Met Gly He Ala Leu Pro Gly Val Val 420 425 430 aac etc cac tat gtc gcc cct gag ate ttt gtc tat gag ggc tac gtg 1344
Asn Leu His Tyr Val Ala Pro Glu He Phe Val Tyr Glu Gly Tyr Val 435 440 445 gtg ata tec agt gga etc ttc tac cag age (SEQ ID NO : 12 ) 1374 Val He Ser Ser Gly Leu Phe Tyr Gin Ser (SEQ ID NO : 4 )
450 455
The BPIL-196 encoded polypeptides have homology (approximately 59% similarity) to human BPI precursor (GenBank Ace. No. AAA51841). Analysis of the BPIL 196 nucleic acid and polypeptide sequences revealed a bactericidal/ permeability increasing factor (BPI)-like high complementarity region which was identified at at nucleotide positions 146-241 (amino acid residues 23-54) and a polyadenylation signal which was identified as beginning at nucleotide position 1457. A search of the NCBI CD-Search database demonstrated that BPIL 196-1 shows significant similarity to three bactericidal/permeability-increasing protein superfamily domains, as shown in Table 4. The NCBI CD-Search is a search of a conserved domain database. Because proteins often contain several modules or domains, each with a distinct evolutionary origin and function, the CD- Search service may be used to identify the conserved domains present in a protein sequence. Computational biologists define conserved domains based on recurring sequence patterns or motifs. CD currently contains domains derived from two popular collections, Smart and Pfam, plus contributions from NCBI. To identify conserved domains in a protein sequence, the CD-Search service employs the reverse position-specific BLAST algorithm. The query sequence is compared to a position-specific score matrix prepared from the underlying conserved domain alignment. Altschul et al., Nucleic Acids Res. 25:3389-3402 (1997). Similar results were found for BPIL 196- 2 , as shown in Table 5.
This degree of homology between a BPLI-196 polypeptide and bactericidal/permeability- increasing protein superfamily domains (both in terms of length and complexity) is very unlikely to have occurred by chance alone as represented by the Expect (E) value in Tables 4 and 5.
Table 4
Score E Sequences producing significant alignments: (bits) value n __IT. T.TΛ BPI/LBP/CETP C-terminal domain; Bactericidal „, , . 1 0 gnl Smart BPI2 , .,._ . 86.6 3e-18 — permeabihty-mcr... gnllPfam|pfam012 LBP BPI CETP; LBP / BPI / CETP family 48.0 le-06 n ^.T.T T, BPI/LBP/CETP N-terminal domain; Bactericidal ._ „ _ ΛΛ1 gnl Smart BPIl , ..._ . 37.9 0.001 a — ' ' permeabihty-incr...
Table S
Score E Sequences producing significant alignments: (bits) value tio ^tr.τ>τ > BPI/LBP/CETP C-terminal domain; Bactericidal „ , , , „ gnllSmartlBPI2 , ..._ . 86.6 3e-18 ° — ' ' permeabihty-mcr... gnllPfam|pfam012 LBP BPι_CETP, LBP / BPI / CETP family 48.8 6e-07 n _-,τ.τvr . BPI/LBP/CETP N-terminal domain; Bactericidal »0 - Λ „ . gnllSmartlBPIl , ...,, . 38.3 9e-04 ° — ' ' permeabihty-incr...
CD multiple alignments of the bactericidal/permeability-increasing protein superfamily domains are presented in Table 6. Black outlined amino acids indicates identity, whereas grey outlined amino acids indicates conservative substitution. Based on its relatedness, the BPIL-196 proteins are novel members of the bactericidal/permeability-increasing protein superfamily.
Table 6
6A. Alignment of BPIL 196 with the BPI/LBP/CETP C-terminal domain
Figure imgf000022_0001
6B. Alignment of BPIL 196 with the BPI/LBP/CETP family domain
Figure imgf000022_0002
80 90 100 no 120
|....|....|....|....|....|....|....| |....|....|....|
196 1 RIRILNVHVJPgLHjlKFI- -gGFGggLLAAANFTFKVgR- -APEPLE 196 2 gi I 2497617 LIPOPOLYSACCHARIDE- gi j 7497995 hypothetical protei gi 1125987 LIPOPOLYSACCHARIDE-B gi 1115110 BACTERICIDAL PERMEAB
Consensus
Figure imgf000023_0001
Figure imgf000023_0002
gi I 2497617 LIPOPOLYSACCHARIDE- (Seq ID No: 55) gi 17497995 hypothetical protei (Seq ID No: 56) gi j 125987 LIPOPOLYSACCHARIDE-B (Seq ID No:57) gi 1115110 BACTERICIDAL PERMEAB (Seq ID No:58) Consensus
Figure imgf000024_0001
(Seq ID No: 59)
6C. Alignment of BPIL 196 with the BPI LBP/CETP N-terminal domain
Figure imgf000024_0002
BPIL-196 polypeptides were modeled using the crystal structure of human bactericidal/permabihty increasing protein ("BPI") (Beamer et al. Science 276, 1997) using GeneAtlas™ software (Molecular Simulations, Inc. ("MSI") San Diego, CA). The model demonstrated tertiary structure similar to BPI. Specifically, the BPIL-196 protein structure has the characteristic boomerang-shape with two domains of other members of the bactericidal/permeability-increasing protein superfamily. Structural overlays of the molecular model of BPIL-196-1 and BPIL-196-2 against BPI using the program Profϊle-3D were performed. Profile 3-D is a threading program which measures the compatibility of the protein model with its sequence using a 3-D profile. Using defined parameters Profile 3-D computes a verify score for the model. A verify score between 0 and 1 correlates to a good model. A verify score under 0 correlates to a bad model. A verify score of 0.49 with 20.2% identity was obtained for BPIL-196-1. Simarily, the verify score for BPIL-196-2 is 0.33, with 21% identity. This confirms the tertiary structural similarity between BPIL-196 and BPI.
In addition, primary sequence structural alignments were also performed. In the following tables, the subject sequence was BPI (GenBank Ace. No. AAA51841) and the annotations therein were derived from that subject sequence. Tables 7 and 8 illustrate the primary sequence alignment with secondary structures of BPI. As illustrated in Table 7 and 8 both BPIL 196-1 and 196-2 have the conserved cysteine residues that are involved in disulfide bond formation between the final stand of the beta sheet and the long alpha helix. Consistent with the conserved tertiary structure, Tables 7 and 8 also illustrate that much of the amino acids in regions of secondary structure are conserved between BPIL-196 and BPI.
Table 7: Primary Sequence Alignment of BPIL 196-1 with Secondary Structure of BPI >HHHHHHHHHHHHHHHHHHHHH >
Sbj Ct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIRE 60 PG WR+ + + L Y S+ G A LQ+ L+ + +P + D + + L I Query 21 STPGTWRLNKAALSYVSEIGKAPLQRALQ-VTVPHFLD-WSGEALQPTRIR ILN 73
Sbj Ct : 61 FQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLG 120
: +P + + G++ + + + +L++ + + AD ++
Query : 74 VHVPRLHLKFIAGFGVRLLAA A FTFKVFRAPEPLELTLP-VELLADTRVT 123 s s
_ > > HHHHHHHHHH - HHHHHHHHHHHHHHHHH
Sbj ct : 121 SNPTSGKPTITCSSCSSHINSV-HVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVT 179
: + P ++ S+CS S S L+ L K I++ L ++++C T
Query : 124 QSSI -RTPWSISACSLFSGHA EFDGSNSTSHALLVLVQKHIKAVL SNKLC-LST 177
HHHHH HHHHH - - > > >
Sbj Ct : 180 NSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPF 239 : +++ + + TL + + + I Y +V+ P T++ + +++ + P Query: 178 SNLVQGVNVHLGTLIGLNPVGPESQIRYSMVSVPTVTSDYISLEVNAVLFLLGKPIILPT 237 .HHHHHHHHHHHHH > HH Sbjct: 240 APPVMEFP AAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTK 296
: P M +GLS F++A L+ Q+AG L + + + L T
Query: 238 DATPFVLPRHVGTEGSMATVGLSQQLFDSALLLLQKAGALNLDITGQLRS- -DDNLLNTS 295
HHHHHH HHHH > > Sbjct: 297 FFGTFLPEVAKKFPN-MKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASL 355 : G +PEVA4-+FP M + + V P + T V+ A NSA SL Query: 296 ALGRLIPEVARQFPEPMPWLKVRLGATPVAMLHTNNATLRLQPFVEVLATASNSAFQSL 355 > HHHHHHHHHHHHHHH-H Sbjct: 356 FLIGMHTTGSMEVSAESNRLVGEL-KLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVL 414 : F + + +++S +L G L + L + SN+G + ++ +M + +L Query: 356 FSLDWVNLRLQLSVSKVKLQGTTSVLGDVQLTVASSNVGFIDTDQVRTLMGTVFEKPLL 415
HHHHHHHHH-> > > Sbjct: 415 PRV EKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No:67)
: +N L G LP + + ++ +++ + + Y+ Query: 416 DHLNALLAMGIALPGW LHYVAPEIFVYEGYWISSGLFYQ 457 (Seq ID No:68)
KEY: H = denotes alpha helix secondary structure > = denotes beta-strand secondary structure (variable amounts of hyphens . H-H = one residue breaks in an alpha helix structure S S = disulfide bond
Table 8: Primary Sequence Alignment ofBPIL 196-2 with Secondary Structure ofBPI >HHHHHHHHHHHHHHHHHHHHH > Sbj ct : 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIRE 60 PG WR+ + + L Y S+ G A LQ+ L ++ +P + D + + L I
Query : 21 STPGTWRLNKAALSYVSEIGKAPLQRAL-QVTVPHFLD-WSGEALQPTRIR ILN 73 > > Sbjct: 61 FQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLK SGNFDLSIEGMSISADLKLG 120 +P + + G++ + + + +L++ + + AD ++
Query: 74 VHVPRLHLKFIAGFGVRLLAA A FTFKVFRAPEPLELTLP-VELLADTRVT 123
S S
- > > HHHHHHHHHH-HHHHHHHHHHHHHHHHH Sbj ct : 121 SNPTSGKPTITCSSCSSHINSV-HVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVT 179 + P ++ S+CS S S L+ L ++ ++ +++++C ++
Query : 124 QSSI -RTPWSISACSLFSGHANEFDGSNSTSHALLVL VQKHIKAVLSNKLCLSIS 178
HHHHH HHHHH --> > > Sbjct: 180 NSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPF 239 N V + + TL + + + I Y +V+ P T++ + +++ + P Query: 179 NLVQ-GVNVHLGTLIGLNPVGPESQIRYSMVSVPTVTSDYISLEVNAVLFLLGKPIILPT 237 >HHHHHHHHHHHHH > HH Sbjct: 240 APPVMEFP AAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTK 296 P M +GLS F++A L+ Q+AG L + + + L T
Query : 238 DATPFVLPRHVGTEGSMATVGLSQQLFDSALLLLQKAGALNLDITGQLRS - -DDNLLNTS 295
HHHHHH HHHH > > Sbj ct : 297 FFGTFLPEVAKKFPN-MKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASL 355 G +PEVA++FP M + + V P + T V+ A NSA SL
Query : 296 ALGRLIPEVARQFPEPMPWLKVRLGATPVAMLHTNNATLRLQPFVEVLATASNSAFQSL 355 > HHHHHHHHHHHHHHH-H Sbjct: 356 FLIGMHTTGSMEVSAESNRLVGEL-KLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVL 414 F + + +++S +L G L + L + SN+G + ++ +M + +L Query: 356 FSLDVWNLRLQLSVSKVKLQGTTSVLGDVQLTVASSNVGFIDTDQVRTLMGTVFEKPLL 415
HHHHHHHHH-> > > Sbjct: 415 PRVNEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No:69)
+N L G LP + + ++ +++ + + Y+ Query: 416 DHLNALLAMGIALPGWNLHYVAPEIFVYEGYWISSGLFYQ 457 (Seq ID No:70)
KEY: H = denotes alpha helix secondary structure > = denotes beta- strand secondary structure (variable amounts of hyphens .
H-H = one residue breaks in an alpha helix structure S S = disulfide bond
NOTE : Residues 17 -45 , 82 - 108 , and 142 - 169 of BPI (public) are considered critical for LPS -binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.276 20 JUNE 1997 pl86i).
Primary sequence alignments within 4 A of the carboxy and amino terminal binding pocket are also illustrated in Tables 9 -12. Amino acids that are underlined in Table 9-12 represent amino acids which comprise the binding pocket. "Binding pocket" means the site where a BPILX ligand interacts ( e.g., charge interaction, hydrophobic forces, van der Waals attraction, hydrogen bonding, dipole interaction and entropy increases) with a BPILX polypeptide. For example, these include amino acid val26, leu29, val37, ser38, ile40, pro44, leuδl, tyrl20, vall22, asnl79, glyl83, vall84, hisl87, leul88, ile218, ala255, pro429, gly430, asn433 of SEQ ID NO:2 as illustrated by underlining in Table 9 (SEQ ID NO:72). In the tables, 9-12 the BPILX sequence of the present invention is the Query and the BPI Accession No. AAA51841 is the Subject. The binding pocket can be defined by at least 2, 3, 4, or 5 of the above-designated amino acids.
Table 9: BPIL 196-1 N-terminal binding pocket
Sbjct: 1 VNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIRE 60 PG WR+++ L Y S+ G A LQ+ L+ + +P + D + + L I
Query: 21 STPGTVVRLNKAALSYVSEIGKAPLQRALQ-VTVPHFLD- SGEALQPTRIR ILN 73
Sbjct: 61 FQLPSSQISMVPNVGLKFSISNANIKISGK KAQKRFLKMSGNFDLSIEGMSISADLKLG 120 : +P + + G++ + + + +L++ + + AD ++
Query: 74 VHVPRLHLKFIAGFGVRLLAA ANFTFKVFRAPEPLELTLP-VELLADTRVT 123
Sbjct: 121 SNPTSGKPTITCSSCSSHINSV-HVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVT 179 : + P ++ S+CS S S L+ L K I++ L ++++C T
Query: 124 QSSI-RTPWSISACSLFSGHANEFDGSNSTSHALLVLVQKHIKAVL SNKLC-LST 177
Sbjct: 180 NSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPF 239
: +++ + + TL + + + I Y +V+ P T++ + +++ + P Query: 178 SNLVQGVNVHLGTLIGLNPVGPESQIRYSMVSVPTVTSDYISLEVNAVLFLLGKPIILPT 237
Sbjct: 240 APPVMEFP AAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTK 296
: P M +GLS F++A L+ Q+AG L + + + L T
Query: 238 DATPFVLPRHVGTEGSMATVGLSQQLFDSALLLLQKAGALNLDITGQLRS- -DDNLLNTS 295
Sbj ct : 297 FFGTFLPEVAKKFPN-MKIQIHVSASTPPHLΞVQPTGLTFYPAVDVQAFAVLPNSALASL 355
: G +PEVA++FP M + + V P + T V+ A NSA SL
Query : 296 ALGRLIPEVARQFPEPMPWLKVRLGATPVAMLHTNNATLRLQPFVEVLATASNSAFQSL 355 Sbj ct 356 FLIGMHTTGSMEVSAESNRLVGEL-KLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVL 414
F + + +++S +L G L + L + SN+G + ++ +M + +L Query 356 FSLDVWNLRLQLSVSKVKLQGTTSVLGDVQLTVASSNVGFIDTDQVRTLMGTVFEKPLL 415
Sbj ct : 415 PRVNEKLOKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No : 71) : +N L G LP + + ++ +++ + + Y+
Query : 416 DHLNALLAMGIALPGWNLHYVAPEIFVYEGYWISSGLFYQ 457 (Seq ID No : 72)
Table 10: BPIL 196-2 N-terminal binding pocket Sbj ct : 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIRE 60 PG WR+++ L Y S+ G A LQ+ L ++ +P + D + + L I
Query : 21 STPGT RLNKAALSYVSEIGKAPLQRAL-QVTVPHFLD-WSGEALQPTRIR ILN 73
Sbj ct : 61 FQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLG 120 +P + + G++ + + + +L++ + + AD ++
Query : 74 VHVPRLHLKFIAGFGVRLLAA ANFTFKVFRAPEPLELTLP-VELLADTRVT 123
Sbj ct : 121 SNPTSGKPTITCSSCSSHINSV-HVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVT 179 + P ++ S+CS S S L+ L ++ ++ +++++C ++
Query: 124 QSSI -RTPWSISACSLFSGHANEFDGSNSTSHALLVL VQKHIKAVLSNKLCLSIS 178
Sbj ct : 180 NSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPF 239 N V + + TL + + + I Y +V+ P T++ + +++ + P
Query : 179 NLVQ-GVNVHLGTLIGLNPVGPESQIRYSMVSVPTVTSDYISLEVNAVLFLLGKPIILPT 237
Sbj ct : 240 APPVMEFP AAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTK 296
P M +GLS F++A L+ Q+AG L + + + L T
Query : 238 DATPFVLPRHVGTEGSMATVGLSQQLFDSALLLLQKAGALNLDITGQLRS - -DDNLLNTS 295
Sbj ct : 297 FFGTFLPEVAKKFPN-MKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASL 355 G +PEVA++FP M + + V P + T V+ A NSA SL
Query : 296 ALGRLIPEVARQFPEPMPWLKVRLGATPVAMLHTNNATLRLQPFVEVLATASNSAFQSL 355
Sbj ct : 356 FLIGMHTTGSMEVSAESNRLVGEL-KLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVL 414 F + + +++S +L G L + L + SN+G + ++ +M + +L
Query : 356 FSLDVWNLRLQLSVSKVKLQGTTSVLGDVQLTVASSNVGFIDTDQVRTLMGTVFEKPLL 415
Sbj ct : 415 PRVNEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No: 73)
+N L G LP + + ++ + + + + + Y+
Query : 416 DHLNALLAMGIALPGWNLHYVAPEIFVYEGYWISSGLFYQ 457 (seq ID No : 74)
NOTE : Residues underlined are ones that are within 4 angstroms of the NH2 - terminal lipid in the BPI crystal structure .
Table 11: 196-1 C-Terminal Binding Pocket
Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIRE 60 PG WR+++ L Y S+ G A LQ+ L+ + +P + D + + L I Query 21 STPGTWRLNKAALSYVSEIGKAPLQRALQ-VTVPHFLD-WSGEALQPTRIR ILN 73
Sbjct 61 FQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLG 120
+P + + G++ + + + +L++ + + AD ++ Query 74 VHVPRLHLKFIAGFGVRLLAA ANFTFKVFRAPEPLELTLP-VELLADTRVT 123
Sbjct: 121 SNPTSGKPTITCSSCSSHINSV-HVHISKSKVG LIQLFHKKIESALRNKMNSQVCEKVT 179
: + P ++ S+CS S S L+ L K I++ L ++++C T Query: 124 QSSI-RTPWSISACSLFSGHANEFDGSNSTSHALLVLVQKHIKAVL SNKLC-LST 177 Sbjct 180 NSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPF 239
+++ + + TL + + + I Y +V+ P T++ + +++ + P Query 178 SNLVQGVNVHLGTLIGLNPVGPESQIRYSMVSVPTVTSDYISLEVNAVLFLLGKPIILPT 237
Sbjct: 240 APPVMEFP AAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTK 296 : P M +GLS F++A L+ Q+AG L + + + L T
Query: 238 DATPFVLPRHVGTEGSMATVGLSQQLFDSALLLLQKAGALNLDITGQLRS - -DDNLLNTS 295
Sbjct: 297 FFGTFLPEVAKKFPN-MKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASL 355 : G +PEVA++FP M + + V P + T V+ A NSA SL Query: 296 ALGRLIPEVARQFPEPMPWLKVRLGATPVAMLHTNNATLRLQPFVEVLATASNSAFQSL 355
Sbjct: 356 FLIGMHTTGSMEVSAESNRLVGEL-KLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVL 414
: F + + +++S +L G L + L + SN+G + ++ +M + +L
Query: 356 FSLDVVyNLRLQLSVSKVKLQGTTSVLGDVQLTVASSNVGFIDTDQVRTLMGTVFEKPLL 415
Sbjct: 415 PRVNEKLQKGFPLPTPARVOLYNWLOPHONFLLFGADWYK 456 (Seq ID No: 75)
: +N L G LP + + ++ +++ + + Y+
Query: 416 DHLNALLAMGIALPGWNLHYVAPEIFVYEGYWISSGLFYQ 457 (Seq ID No:76)
Table 12: BPIL 196-2 C-terminal binding pocket
Sbj ct : 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIRE 60 PG WR+++ L Y S+ G A LQ+ L ++ +P + D + + L I Query: 21 STPGTWRLNKAALSYVSEIGKAPLQRAL-QVTVPHFLD-WSGEALQPTRIR ILN 73
Sbjct: 61 FQLPSSQISMVPNVGLKFSISNANIKISGK KAQKRFLKMSGNFDLSIEGMSISADLKLG 120 +P + + G++ + + + +L++ + + AD ++
Query: 74 VHVPRLHLKFIAGFGVRLLAA ANFTFKVFRAPEPLELTLP-VELLADTRVT 123
Sbjct: 121 SNPTSGKPTITCSSCSSHINSV-HVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVT 179 + P ++ S+CS S S L+ L ++ ++ +++++C ++
Query: 124 QSSI-RTPWSISACSLFSGHANEFDGSNSTSHALLVL VQKHIKAVLSNKLCLSIS 178
Sbjct: 180 NSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPF 239 N V + + TL + + + I Y +V+ P T++ + +++ + P
Query: 179 NLVO-GVNVHLGTLIGLNPVGPESQIRYSMVSVPTVTSDYISLEVNAVLFLLGKPIILPT 237
Sbjct: 240 APPVMEFP AAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTK 296 P M +GLS F++A L+ Q+AG L + + + L T
Query: 238 DATPFVLPRHVGTEGSMATVGLSQQLFDSALLLLQKAGALNLDITGQLRS - -DDNLLNTS 295
Sbjct: 297 FFGTFLPEVAKKFPN-MKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASL 355 G +PEVA++FP M + + V P + T V+ A NSA SL
Query: 296 ALGRLIPEVARQFPEPMPWLKVRLGATPVAMLHTNNATLRLQPFVEVLATASNSAFQSL 355
Sbjct: 356 FLIGMHTTGSMEVSAESNRLVGEL-KLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVL 414 F + + +++S +L G L + L + SN+G + ++ +M + +L
Query: 356 FSLDVVVNLRLQLSVSKVKLQGTTSVLGDVQLTVASSNVGFIDTDQVRTLMGTVFEKPLL 415
Sbjct: 415 PRVNEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No:77) +N L G LP + + ++ +++ + + Y+
Query: 416 DHLNALLAMGIALPGWNLHYVAPEIFVYEGYWISSGLFYQ 457 (Seq ID No:78)
As Tables 9-12 demonstrate, in both the N-terminal and C-terminal binding pockets, the amino acids defining the binding site topography are conserved between the novel BPILX of this invention and the known BPI.
BPIL-232 Genes
Six novel BPIL-232 genes were identified, BPIL 232-1, BPIL 232-2, BPIL 232-3, BPIL 232-4, BPIL 232-5, BPIL 232-6 (hereinafter collectively referred to as "BPIL-232"). A BPIL-232 nucleic acid and its encoded polypeptide include the sequences shown in Table 13-18.
The disclosed BPIL-232- 1 nucleic acid (SEQ ID NO: 5) contains a 1427 nucleotide open reading frame (ORF, SEQ ID NO: 13) that begins with an ATG initiation codon at nucleotides 94- 96. The representative ORF includes a 476 amino acid polypeptide (SEQ ID NO: 6). The program Signal P, predicts a signal peptidase cleavage site between amino acids 23 and 24.
The disclosed BPIL-232-2 nucleic acid (SEQ ID NO: 7) contains a 1427 nucleotide open reading frame (ORF, SEQ ID NO: 14) that begins with an ATG initiation codon at nucleotides 94- 96. The representative ORF includes a 476 amino acid polypeptide (SEQ ID NO: 8). The program Signal P, predicts a signal peptidase cleavage site between amino acids 23 and 24.
The disclosed BPIL-232-3 nucleic acid (SEQ ID NO: 26) contains a 1518 nucleotide open reading frame (ORF, SEQ ID NO: 30) that begins with an ATG initiation codon at nucleotides ???. The representative ORF includes a 507 amino acid polypeptide (SEQ ID NO: 27). The program Signal P, predicts a signal peptidase cleavage site between amino acids 23 and 24.
The disclosed BPIL-232-4 nucleic acid (SEQ ID NO: 28) contains a 1367 nucleotide open reading frame (ORF, SEQ ID NO: 31) that begins with an ATG initiation codon. The representative ORF includes a 455 amino acid polypeptide (SEQ ID NO: 29). The program Signal P, predicts a signal peptidase cleavage site between amino acids 23 and 24. The disclosed BPIL-232-5 nucleic acid (SEQ ID NO: 38) contains a 1518 nucleotide open reading frame (ORF, SEQ ID NO: 42) that begins with an ATG initiation codon. The representative ORF includes a 507 amino acid polypeptide (SEQ ID NO: 39). The program Signal P, predicts a signal peptidase cleavage site between amino acids 23 and 24.
The disclosed BPIL-232-6 nucleic acid (SEQ ID NO: 40) contains a 1367 nucleotide open reading frame (ORF, SEQ ID NO: 43) that begins with an ATG initiation codon. The representative ORF includes a 455 amino acid polypeptide (SEQ ID NO: 41). The program Signal P, predicts a signal peptidase cleavage site between amino acids 23 and 24.
BPIL 232-1 and 232-2 differ by a single nucleotide polymorphism at nucleotide 1444. Specifically, nucleotide 1444 of SEQ ID NO: 5 is a cytosine whereas the nucleotide 1444 of SEQ ID NO: 7 is thymine. This difference results in a change in BPIL-232-6 amino acid residue 451 from a proline in BPIL-232- 1 to a serine in BPIL-232-2. BPIL-232-3 and BPIL-232-5 differ by a single nucleotide polymorphism at nucleotide 1444. Specifically, nucleotide 1444 of SEQ ID NO: 38 is a cytosine whereas the nucleotide 1444 of SEQ ID NO: 26 is thymine. This difference results in a change in amino acid residue 451 from a proline in BPIL-232-5 to a serine in BPIL-232-3. BPIL-232-6 and BPLI-232-4 differ by a single nucleotide polymorphism at nucleotide 1288.
Specifically, nucleotide 1288 of SEQ ID NO: 40 is a cytosine whereas the nucleotide 1288 of SEQ ID NO: 28 is thymine. This difference results in a change in amino acid residue 399 from a proline in BPIL-232-6 to a serine in BPIL-232-4.
Analysis ofthe BPIL 232 nucleic acid and polypeptide sequences revealed three bactericidal/ permeability increasing factor (BPI)-like high complementarity regions. These regions include nucleotide positions 94-162, 721-852 (amino acid residues 210-253), and 913-1023 (amino acid residues 274-310). A polyadenylation signal beginning at nucleotide position 1522 was also identified.
Table 13: Nucleic Acid and Polypeptide Sequences ofBPIL232-1
13A: Nucleic Acid Sequences ttgaggacaccttgattaacctccaagggcaactaaaggatcaagaaaggcccagcacagcagaaga tcagctggatctagctcctgcaggagatgtgtacaaagacaatcccagtcctctggggatgtttcctcctgtggaatct ctatgtctcatcctctcagaccatttaccctggaatcaaggcaaggattactcagagggcacttgactatggtgttcaa gctggaatgaagatgattgagcaaatgctaaaagaaaagaaactcccagatttaagcggttctgagtctcttgaatttc taaaagttgattatgtaaactacaatttttcaaatataaaaatcagtgccttttcatttccaaatacctcattggcttt tgtgcctggagtgggaatcaaagcgctaaccaaccatggcactgccaacatcagcacagactgggggttcgagtctcca ctttccaagacacaggaggggctgatctgtttctctccggagtctacttaccggtatcattatcctaaccgaaatgact ttggtcatcctaccctgaagctccaagattgctacgcccaactgagccatgccacgtctcatttccggagaactcagtg ttctgtataactcctttgctgagccatggagaaaccgagtatttctttaaatctgcgtcctt gctcat tcacagctg gggttttcaatgtcactctctccaccgaagagatttccaaccattttgttcaaaactctcaaggccttggcaacgtgct ctcccggattgcagagatctacatcttgtcccagcccttcatggtgaggatcatggccacagagcctcccataatcaat ctacaaccaggcaatttcaccctggacatccctgcctccatcatgatgctcacccaacccaagaactccacagttgaaa ccatcgtttccatggacttcgttgctagtaccagtgttggcctggttattttgggacaaagactggtctgctccttgtc tctgaacagattccgccttgctttgccagagtccaatcgcagcaacattgaggtcttgaggtttgaaaatattctatcg tccattcttcactttggagtcctcccactggccaatgcaaaattgcagcaaggatttcctctgcccaatccacacaaat tcttattcgtcaattcagatattgaagttcttgaggtaagaatgcaaatctcacctcttaactgacccatttcttttta tagtagactaagcctcctcctgttttgcttgtttttgttgttgttgtttgtttttgtcctgctttgctttttcccagac cagggaatcttataaacatgtttagttcttaaatcacaattaacagaaaatatttagagttgagtctaaaaatcagacc aagatcaatttcacttagcagccaaatccacagtataagaagatgccccttagc (SEQ ID NO: 5)
13B: Polypeptide Sequence
MCTKTIPVL GCFLL NLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYN FSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTD GFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKL QDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSP EITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEISNHFVQN SQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILG QRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKFLFVNSDIEVLEVRMQISP LN (SEQ ID NO: 6)
13C: Open Reading Frame atg tgt aca aag aca ate cca gtc etc tgg gga tgt ttc etc ctg tgg 48
Met Cys Thr Lys Thr lie Pro Val Leu Trp Gly Cys Phe Leu Leu Trp 1 5 10 15 aat etc tat gtc tea tec tct cag ace att tac cct gga ate aag gca 96
Asn Leu Tyr Val Ser Ser Ser Gin Thr lie Tyr Pro Gly lie Lys Ala
20 25 30 agg att act cag agg gca ctt gac tat ggt gtt caa get gga atg aag 144
Arg lie Thr Gin Arg Ala Leu Asp Tyr Gly Val Gin Ala Gly Met Lys
35 40 45 atg att gag caa atg eta aaa gaa aag aaa etc cca gat tta age ggt 192 Met lie Glu Gin Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly
50 55 60 tct gag tct ctt gaa ttt eta aaa gtt gat tat gta aac tac aat ttt 240
Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe 65 70 75 80 tea aat ata aaa ate agt gcc ttt tea ttt cca aat ace tea ttg get 288
Ser Asn lie Lys lie Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
85 90 95 ttt gtg cct gga gtg gga ate aaa gcg eta ace aac cat ggc act gcc 336
Phe Val Pro Gly Val Gly lie Lys Ala Leu Thr Asn His Gly Thr Ala
100 105 110 aac ate age aca gac tgg ggg ttc gag tct cca ctt ttc caa gac aca 384
Asn lie Ser Thr Asp Trp Gly Phe Glu Ser Pro Leu Phe Gin Asp Thr
115 120 125 gga ggg get gat ctg ttt etc tec gga gtc tac ttt ace ggt ate att 432 Gly Gly Ala Asp Leu Phe Leu Ser Gly Val Tyr Phe Thr Gly He He
130 135 140 ate eta ace cga aat gac ttt ggt cat cct ace ctg aag etc caa gat 480
He Leu Thr Arg Asn Asp Phe Gly His Pro Thr Leu Lys Leu Gin Asp 145 150 155 160 tgc tac gcc caa ctg age cat gcc cac gtc tea ttt tec gga gaa etc 528
Cys Tyr Ala Gin Leu Ser His Ala His Val Ser Phe Ser Gly Glu Leu
165 170 175 agt gtt ctg tat aac tec ttt get gag ccc atg gag aaa ccc att tta 576
Ser Val Leu Tyr Asn Ser Phe Ala Glu Pro Met Glu Lys Pro He Leu
180 185 190 aag aac tta aat gaa atg etc tgt ccc att att gca agt gaa gtc aaa 624
Lys Asn Leu Asn Glu Met Leu Cys Pro He He Ala Ser Glu Val Lys
195 200 205 gcg eta aat gcc aac etc age aca ctg gag gtt tta ace aag att gac 672 Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu Val Leu Thr Lys He Asp
210 215 220 aac tac act ctg ctg gat tac tec eta ate agt tct cca gaa att act 720
Asn Tyr Thr Leu Leu Asp Tyr Ser Leu He Ser Ser Pro Glu He Thr 225 230 235 240 gag aac tac ctt gac ctg aac ttg aag ggt gta ttc tac cca ctg gaa 768 Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly Val Phe Tyr Pro Leu Glu 245 250 255 aac etc ace gac ccc ccc ttc tea cca gtt cct ttt gtg etc cca gaa 816 Asn Leu Thr Asp Pro Pro Phe Ser Pro Val Pro Phe Val Leu Pro Glu 260 265 270 cgc age aac tec atg etc tac att gga ate gcc gag tat ttc ttt aaa 864 Arg Ser Asn Ser Met Leu Tyr He Gly He Ala Glu Tyr Phe Phe Lys 275 280 285 tct gcg tec ttt get cat ttc aca get ggg gtt ttc aat gtc act etc 912 Ser Ala Ser Phe Ala His Phe Thr Ala Gly Val Phe Asn Val Thr Leu 290 295 300 tec ace gaa gag att tec aac cat ttt gtt caa aac tct caa ggc ctt 960 Ser Thr Glu Glu He Ser Asn His Phe Val Gin Asn Ser Gin Gly Leu 305 310 315 320 ggc aac gtg etc tec egg att gca gag ate tac ate ttg tec cag ccc 1008 Gly Asn Val Leu Ser Arg He Ala Glu He Tyr He Leu Ser Gin Pro 325 330 335 ttc atg gtg agg ate atg gcc aca gag cct ccc ata ate aat eta caa 1056 Phe Met Val Arg He Met Ala Thr Glu Pro Pro He He Asn Leu Gin 340 345 350 cca ggc aat ttc ace ctg gac ate cct gcc tec ate atg atg etc ace 1104 Pro Gly Asn Phe Thr Leu Asp He Pro Ala Ser He Met Met Leu Thr 355 360 365 caa ccc aag aac tec aca gtt gaa ace ate gtt tec atg gac ttc gtt 1152 Gin Pro Lys Asn Ser Thr Val Glu Thr He Val Ser Met Asp Phe Val 370 375 380 get agt ace agt gtt ggc ctg gtt att ttg gga caa aga ctg gtc tgc 1200 Ala Ser Thr Ser Val Gly Leu Val He Leu Gly Gin Arg Leu Val Cys 385 390 395 400 tec ttg tct ctg aac aga ttc cgc ctt get ttg cca gag tec aat cgc 1248 Ser Leu Ser Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg 405 410 415 age aac att gag gtc ttg agg ttt gaa aat att eta teg tec att ctt 1296 Ser Asn He Glu Val Leu Arg Phe Glu Asn He Leu Ser Ser He Leu 420 425 430 cac ttt gga gtc etc cca ctg gcc aat gca aaa ttg cag caa gga ttt 1344 His Phe Gly Val Leu Pro Leu Ala Asn Ala Lys Leu Gin Gin Gly Phe 435 440 4_5 cct ctg ccc aat cca cac aaa ttc tta ttc gtc aat tea gat att gaa 1392 Pro Leu Pro Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp He Glu 450 455 460 gtt ctt gag gta aga atg caa ate tea cct ctt aac (Seq ID NO: 13) 1428 Val Leu Glu Val Arg Met Gin He Ser Pro Leu Asn (Seq ID NO: 6) 465 470 475
Table 14: Nucleic Acid and Polypeptide Sequences of BPIL232-2 14A: Nucleic Acid Sequences
TTGAGGACACCTTGATTAACCTCCAAGGGCAACTAAAGGATCAAGAAAGGCCCAGCACAGCAGAAGATCAGCTGGATCT AGCTCCTGCAGGAGatgtgtacaaagacaatcccagtcctctggggatgtttcctcctgtggaatctctatgtctcatc ctctcagaccatttaccctggaatcaaggcaaggattactcagagggcacttgactatggtgttcaagctggaatgaag atgattgagcaaatgctaaaagaaaagaaactcccagatttaagcggttctgagtctcttgaatttctaaaagttgatt atgtaaactacaatttttcaaatataaaaatcagtgccttttcatttccaaatacctcattggcttttgtgcctggagt gggaatcaaagcgctaaccaaccatggcactgccaacatcagcacagactgggggttcgagtctccacttttccaagac acaggaggggctgatctgtttctctccggagtctactttaccggtatcattatcctaacccgaaatgactttggtcatc ctaccctgaagctccaagattgctacgcccaactgagccatgcccacgtctcattttccggagaactcagtgttctgta taactccttcctcaccgacccccccttctcaccagttccttttgtgctcccagaacgcagcaactccatgctctacatt ggaatcgccgagtatttctttaaatctgcgtcctttgctcatttcacagctggggttttcaatgtcactctctccaccg aagagatttccaaccattttgttcaaaactctcaaggccttggcaacgtgctctcccggattgcagagatctacatctt gtcccagcccttcatggtgaggatcatggccacagagcctcccataatcaatctacaaccaggcaatttcaccctgga catccctgcctccatcatgatgctcacccaacccaagaactccacagttgaaaccatcgtttccatggacttcgttgct agtaccagtgttggcctggttattttgggacaaagactggtctgctccttgtctctgaacagattccgccttgctttgc cagagtccaatcgcagcaacattgaggtcttgaggtttgaaaatattctatcgtccattcttcactttggagtcctccc actggccaatgcaaaattgcagcaaggatttcctctgtccaatccacacaaattct attcgtcaattcagatattgaa gttcttgaggtaagaatgcaaatctcacctcttaactgacccatttctttttatagtagactaagcctcctcctgtttt gcttgtttttgttgttgttgtttgtttttgtcctgctttgctttttcccagaccagggaatcttataaacatgtttagt tcttaaatcacaattaacagaaaatatttagagttgagtctaaaaatcagaccaagatcaatttcac tagcagccaaa tccacagtataagaagatgccccttagc (SEQ ID NO 7)
14B: Polypeptide Sequence
MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYN FSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTD GFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKL QDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSP EITLN (SEQ ID NO: 8)
14C: Open Reading Frame atg tgt aca aag aca ate cca gtc etc tgg gga tgt ttc etc ctg tgg 48 Met Cys Thr Lys Thr He Pro Val Leu Trp Gly Cys Phe Leu Leu Trp 1 5 10 15 aat etc tat gtc tea tec tct cag ace att tac cct gga ate aag gca 96 Asn Leu Tyr Val Ser Ser Ser Gin Thr He Tyr Pro Gly He Lys Ala
20 25 30 agg att act cag agg gca ctt gac tat ggt gtt caa get gga atg aag 144 Arg He Thr Gin Arg Ala Leu Asp Tyr Gly Val Gin Ala Gly Met Lys 35 40 45 atg att gag caa atg eta aaa gaa aag aaa etc cca gat tta age ggt 192 Met He Glu Gin Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly 50 55 60 tct gag tct ctt gaa ttt eta aaa gtt gat tat gta aac tac aat ttt 240
Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe
65 70 75 80 tea aat ata aaa ate agt gcc ttt tea ttt cca aat ace tea ttg get 288
Ser Asn He Lys He Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala
85 90 95 ttt gtg cct gga gtg gga ate aaa gcg eta ace aac cat ggc act gcc 336 Phe Val Pro Gly Val Gly He Lys Ala Leu Thr Asn His Gly Thr Ala
100 105 110 aac ate age aca gac tgg ggg ttc gag tct cca ctt ttc caa gac aca 384
Asn He Ser Thr Asp Trp Gly Phe Glu Ser Pro Leu Phe Gin Asp Thr 115 120 125 gga ggg get gat ctg ttt etc tec gga gtc tac ttt ace ggt ate att 432
Gly Gly Ala Asp Leu Phe Leu Ser Gly Val Tyr Phe Thr Gly He He
130 135 140 ate eta ace cga aat gac ttt ggt cat cct ace ctg aag etc caa gat 480
He Leu Thr Arg Asn Asp Phe Gly His Pro Thr Leu Lys Leu Gin Asp
145 150 155 160 tgc tac gcc caa ctg age cat gcc cac gtc tea ttt tec gga gaa etc 528
Cys Tyr Ala Gin Leu Ser His Ala His Val Ser Phe Ser Gly Glu Leu
165 170 175 agt gtt ctg tat aac tec ttt get gag ccc atg gag aaa ccc att tta 576 Ser Val Leu Tyr Asn Ser Phe Ala Glu Pro Met Glu Lys Pro He Leu
180 185 190 aag aac tta aat gaa atg etc tgt ccc att att gca agt gaa gtc aaa 624
Lys Asn Leu Asn Glu Met Leu Cys Pro He He Ala Ser Glu Val Lys 195 200 205 gcg eta aat gcc aac etc age aca ctg gag gtt tta ace aag att gac 672
Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu Val Leu Thr Lys He Asp
210 215 220 aac tac act ctg ctg gat tac tec eta ate agt tct cca gaa att act 720
Asn Tyr Thr Leu Leu Asp Tyr Ser Leu He Ser Ser Pro Glu He Thr
225 230 235 240 gag aac tac ctt gac ctg aac ttg aag ggt gta ttc tac cca ctg gaa 768
Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly Val Phe Tyr Pro Leu Glu
245 250 255 aac etc ace gac ccc ccc ttc tea cca gtt cct ttt gtg etc cca gaa 816 Asn Leu Thr Asp Pro Pro Phe Ser Pro Val Pro Phe Val Leu Pro Glu
260 265 270 cgc age aac tec atg etc tac att gga ate gcc gag tat ttc ttt aaa 864
Arg Ser Asn Ser Met Leu Tyr He Gly He Ala Glu Tyr Phe Phe Lys 275 280 285 tct gcg tec ttt get cat ttc aca get ggg gtt ttc aat gtc act etc 912 Ser Ala Ser Phe Ala His Phe Thr Ala Gly Val Phe Asn Val Thr Leu 290 295 300 tec ace gaa gag att tec aac cat ttt gtt caa aac tct caa ggc ctt 960 Ser Thr Glu Glu He Ser Asn His Phe Val Gin Asn Ser Gin Gly Leu 305 310 315 320 ggc aac gtg etc tec egg att gca gag ate tac ate ttg tec cag ccc 1008 Gly Asn Val Leu Ser Arg He Ala Glu He Tyr He Leu Ser Gin Pro 325 330 335 ttc atg gtg agg ate atg gcc aca gag cct ccc ata ate aat eta caa 1056 Phe Met Val Arg He Met Ala Thr Glu Pro Pro He He Asn Leu Gin 340 345 350 cca ggc aat ttc ace ctg gac ate cct gcc tec ate atg atg etc ace 1104 Pro Gly Asn Phe Thr Leu Asp He Pro Ala Ser He Met Met Leu Thr 355 360 365 caa ccc aag aac tec aca gtt gaa ace ate gtt tec atg gac ttc gtt 1152 Gin Pro Lys Asn Ser Thr Val Glu Thr He Val Ser Met Asp Phe Val 370 375 380 get agt ace agt gtt ggc ctg gtt att ttg gga caa aga ctg gtc tgc 1200 Ala Ser Thr Ser Val Gly Leu Val He Leu Gly Gin Arg Leu Val Cys 385 390 395 400 tec ttg tct ctg aac aga ttc cgc ctt get ttg cca gag tec aat cgc 1248 Ser Leu Ser Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg 405 410 415 age aac att gag gtc ttg agg ttt gaa aat att eta teg tec att ctt 1296 Ser Asn He Glu Val Leu Arg Phe Glu Asn He Leu Ser Ser He Leu 420 425 430 cac ttt gga gtc etc cca ctg gcc aat gca aaa ttg cag caa gga ttt 1344 His Phe Gly Val Leu Pro Leu Ala Asn Ala Lys Leu Gin Gin Gly Phe 435 440 445 cct ctg tec aat cca cac aaa ttc tta ttc gtc aat tea gat att gaa 1392
Pro Leu Ser Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp He Glu
450 455 460 gtt ctt gag gta aga atg caa ate tea cct ctt aac (Seq ID No: 14) 1428 Val Leu Glu Val Arg Met Gin He Ser Pro Leu Asn (Seq ID No: 8)
465 470 475
Table 15: Nucleic Acid and Polypeptide Sequences of BPIL232-3 15A: Nucleic Acid Sequences
TTGAGGACACCTTGATTAACCTCCAAGGGCAACTAAAGGATCAAGAAAGGCCCAGCACAGCAGAAGATCAGCTGGATCT AGCTCCTGCAGGAGatgtgtacaaagacaatcccagtcctctggggatgtttectcctgtggaatctctatgtcteat cctctcagaccatttaccctggaatcaaggcaaggattactcagagggcacttgactatggtgttcaagctggaatgaa gatgattgagcaaatgctaaaagaaaagaaactcccagatttaagcggttctgagtctcttgaatttctaaaagttgat tatgtaaactacaatttttcaaatataaaaatcagtgccttttcatttccaaatacctcattggcttttgtgcctggag tgggaatcaaagcgctaaccaaccatggcactgccaacatcagcacagactgggggttcgagtctccacttttccaaga cacaggaggggctgatctgtttctctccggagtctactttaccggtatcattatcctaacccgaaatgactttggtcat cctaccctgaagctccaagattgctacgcccaactgagccatgcccacgtctcattttccggagaactcagtgttctgt ataactcctttgctgagcccatggagaaacccattttaaagaacttaaatgaaatgctctgtcccattattgcaagtga agtcaaagcgctaaatgccaacctcagcacactggaggttttaaccaagattgacaactacactctgctggattactcc ctaatcagttctccagaaattactgagaactaccttgacctgaacttgaagggattgcagagatctacatcttgtccca gcccttcatggtgaggatcatggccacagagcctcccataatcaatctacaaccaggcaatttcaccctggacatccct gcctccatcatgatgctcacccaacccaagaactccacagttgaaaccatcgtttccatggacttcgttgctagtacca gtgttggcctggttattttgggacaaagactggtctgctccttgtctctgaacagattccgccttgctttgccagagtc caatcgcagcaacattgaggtcttgaggtttgaaaatattctatcgtccattcttcactttggagtcctcccactggcc aatgcaaaattgcagcaaggatttcctctgtccaatccacacaaattcttattcgtcaattcagatattgaagttcttg agggtttccttttgatttccaccgacctgaagtatgaaacatcctcaaagcagcagccaagtttccacgtatgggaagg tctgaacctgataagcagacagtggagggggaagtcagccccttgaTTGCCGGTTTGCAATTCACCCCAGGAAGTAAAT GGTCCTTAATCCTACAACTACTGTAAACCCAGAAGGGAAAGACAGTACACACTGGAATTGTAAAGCCCTTGTGAATTGC TTAGGCAGAAAGTTTTCTTTCTTAAGCCTTCAGGAACCCAGAATAAGGCAGACTCTGTTAAAGGGATAAATAGAGGTGT CTGAATGTGAGTGTATGCATGCTGCGTGTGTCTGTGTTTATGTTTGTTTGTTTGTTTGGGGCAAGAAAGATTCTAGGAC AAGAGCTAGGCATGTACTTCTGACCAGGTGGGTAAGCAACTCTAAGTCTGTATTTGTATTGGTCATTCTCAGTGGAAAT CCCTTAGGCCCTCTAGTGGTTTTCCCCTACCTGCATATTGGTTTTCATGTTTTATATTCACTGTTACTATCTTCTGTGT TTAATTAAAATTGTTTTCTATCAA (SEQ ID NO : 26)
15B: Polypeptide Sequences
MCTKTIPVLWGCFLL NLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYN FSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKL QDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSP EITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEISNHFDLK YETSSKQQPSFHVWEGLNLISRQWRGKSAP (SEQ ID NO: 27) 15C: Open Reading Frame atgtgtacaaagacaatcccagtcctctggggatgtttcctcctgtggaatctctatgtctcatcctctcagaccattt accctggaatcaaggcaaggattactcagagggcacttgactatggtgttcaagctggaatgaagatgattgagcaaat gctaaaagaaaagaaactcccagatttaagcggttctgagtctcttgaatttctaaaagttgattatgtaaactacaat ttttcaaatataaaaatcagtgccttttcatttccaaatacctcattggcttttgtgcctggagtgggaatcaaagcgc taaccaaccatggcactgccaacatcagcacagactgggggttcgagtctccacttttccaagacacaggaggggctga tctgtttctctccggagtctactttaccggtatcattatcctaacccgaaatgactttggtcatcctaccctgaagctc caagattgctacgcccaactgagccatgcccacgtctcattttccggagaactcagtgttctgtataactcctttgctg agcccatggagaaacccattttaaagaacttaaatgaaatgctctgtcccattattgcaagtgaagtcaaagcgctaaa tgccaacctcagcacactggaggttttaaccaagattgacaactacactctgctggattactccctaatcagttctcca gaaattactgagaactaccttgacctgaacttgaagggtgtattctacccactggaaaaccaggcaatttcaccctgga catccctgcctccatcatgatgctcacccaacccaagaactccacagttgaaaccatcgtttccatggacttcgttgct agtaccagtgttggcctggttattttgggacaaagactggtctgctccttg ctctgaacagattccgccttgctttgc cagagtccaatcgcagcaacattgaggtcttgaggtttgaaaatattctatcgtccattcttcactttggagtcctccc actggccaatgcaaaattgcagcaaggatttcctctgtccaatccacacaaattcttattcgtcaattcagatattgaa gttcttgagggtttccttttgatttccaccgacctgaagtatgaaacatcctcaaagcagcagccaagtttccacgtat gggaaggtctgaacctgataagcagacagtggagggggaagtcagccccttga (SEQ ID NO: 30)
Table 16: Nucleic Acid and Polypeptide Sequences of BPIL232-4 16A: Nucleic Acid Sequences
TTGAGGACACCTTGACTAACCTCCAAGGGCAACTAAAGGATCAAGAAAGGCCCAGCACAGCAGAAGA TCAGCTGGATCTAGCTCCTGCAGGAGATGTGTACAAAGACAATCCCAGTCCTCTGGGGATGTTTCCTC CTGTGGAATCTCTATGTCTCATCCTCTCAGACCATTTACCCTGGAATCAAGGCAAGGATTACTCAGAG GGCACTTGACTATGGTGTTCAAGCTGGAATGAAGATGATTGAGCAAATGCTAAAAGAAAAGAAACTCC CAGATTTAAGCGGTTCTGAGTCTCTTGAATTTCTAAAAGTTGATTATGTAAACTACAATTTTTCAAATAT AAAAATCAGTGCCTTTTCATTTCCAAATACCTCATTGGCTTTTGTGCCTGGAGTGGGAATCAAAGCGCT AACCAACCATGGCACTGCCAACATCAGCACAGACTGGGGGTTCGAGTCTCCACTTTTTGTTCTGTATA ACTCCTTTGCTGAGCCCATGGAGAAACCCATTTTAAAGAACTTAAATGAAATGCTCTGTCCCATTATTG CAAGTGAAGTCAAAGCGCTAAATGCCAACCTCAGCACACTGGAGGTTTTAACCAAGATTGACAACTAC ACTCTGCTGGATTACTCCCTAATCAGTTCTCCAGAAATTACTGAGAACTACCTTGACCTGAACTTGAAG GGTGTATTCTACCCACTGGAAAACCTCACCGACCCCCCCTTCTCACCAGTTCCTTTTGTGCTCCCAGA ACGCAGCAACTCCATGCTCTACATTGGAATCGCCGAGTATTTCTTTAAATCTGCGTCCTTTGCTCATTT CACAGCTGGGGTTTTCAATGTCACTCTCTCCACCGAAGAGATTTCCAACCATTTTGTTCAAAACTCTCA AGGCCTTGGCAACGTGCTCTCCCGGATTGCAGAGATCTACATCTTGTCCCAGCCCTTCATGGTGAGG ATCATGGCCACAGAGCCTCCCATAATCAATCTACAACCAGGCAATTTCACCCTGGACATCCCTGCCTC CATCATGATGCTCACCCAACCCAAGAACTCCACAGTTGAAACCATCGTTTCCATGGACTTCGTTGCTA GTACCAGTGTTGGCCTGGTTATTTTGGGACAAAGACTGGTCTGCTCCTTGTCTCTGAACAGATTCCGC CTTGCTTTGCCAGAGTCCAATCGCAGCAACATTGAGGTCTTGAGGTTTGAAAATATTCTATCGTCCATT CTTCACTTTGGAGTCCTCCCACTGGCCAATGCAAAATTGCAGCAAGGATTTCCTCTGCCCAATCCACA CAAATTCTTATTCGTCAATTCAGATATTGAAGTTCTTGAGGGTTTCCTTTTGATTTCCACCGACCTGAA GTATGAAACATCCTCAAAGCAGCAGCCAAGTTTCCACGTATGGGAAGGTCTGAACCTGATAAGCAGA CAGTGGAGGGGGAAGTCAGCCCCTTGATTGCCGGTTTGCAATTCACCCCAGGAAGTAAATGGTCCTT AATCCTACAACTACTGTAAACCCAGAAGGGAAAGACAGTACACACTGGAATTGTAAAGCCCTTGTGAA TTGCTTAGGCAGAAAGTTTTCTTTCTTAAGCCTTCAGGAACCCAGAATAAGGCAGACTCTGTTAAAGG GATAAATAGAGGTGTCTGAATGTGAGTGTATGCATGCTGCGTGTGTCTGTGTTTATGTTTGTTTGTTTG TTTGGGGCAAGAAAGATTCTAGGACAAGAGCTAGGCATGTACTTCTGACCAGGTGGGTAAGCAACTC TAAGTCTGTATTTGTATTGGTCATTCTCAGTGGAAATCCCTTAGGCCCTCTAGTGGTTTTCCCCTACCT GCATATTGGTTTTCATGTTTTATATTCACTGTTACTATCTTCTGTGTTTAATTAAAATTGTTTTCTATCAA AAAAAAAAAAA (SEQ ID NO: 28)
16B: Polypeptide Sequences
MCTKTIPVLWGCFLL NLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYN FSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTD GFESPLFVLYNSFAEPMEKPILKNLNEMLCPIIASEVKAL NANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGIAEYFFKS ASFAHFTAGVFNVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLT QPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQG FPLPNPHKFLFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHVWEGLNLISRQWRGKSAP (SEQ ID NO: 29)
16C: Open Reading Frame
MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLK VDYVNYNFSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFVLYNSFAEPMEKPILKNLNEMLCPII ASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGI AEYFFKSASFAHFTAGVFNVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIP ASIMM (SEQ ID NO: 31)
Table 17: Nucleic Acid and Polypeptide Sequences ofBPIL232-5 17A: Nucleic Acid Sequences
TTGAGGACACCTTGATTAACCTCCAAGGGCAACTAAAGGATCAAGAAAGGCCCAGCACAGCAGAAGATCAGCTGGATCT AGCTCCTGCAGGAGatgtgtacaaagacaatcccagtcctctggggatgtttcctcctgtggaatctctatgtctcatc ctctcagaccatttaccctggaatcaaggcaaggattactcagagggcacttgactatggtgttcaagctggaatgaag atgattgagcaaatgctaaaagaaaagaaactcccagatttaagcggttctgagtctcttgaatttctaaaagttgatt atgtaaactacaatttttcaaatataaaaatcagtgccttttcatttccaaatacctcattggcttttgtgcctggagt gggaatcaaagcgctaaccaaccatggcactgccaacatcagcacagactgggggttcgagtctccacttttccaagac acaggaggggctgatctgtt ctctccggagtctactttaccggtatcattatcctaacccgaaatgactttggtcatc ctaccctgaagctccaagattgctacgcccaactgagccatgcccacgtctcattttccggagaactcagtgttctgta taactcctttgctgagcccatggagaaacc (SEQ ID NO : 38 )
17B: Polypeptide Sequences
MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKV DYVNYNFSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTD GFESPLFQDTGGADLFLSGVYFTGIIILTRNDFG HPTLKLQDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDY SLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS NHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSV GLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKFLFVNSDIEVLEG FLLISTDLKYETSSKQQPSFHVWEGLNLISRQWRGKSAP (SEQ ID NO: 39)
17C: Open Reading Frame ctatcgtccattcttcactttggagtcctcccactggccaatgcaaaattgcagcaaggatttcctctgcccaatccac acaaattcttattcgtcaattcagatattgaagttcttgagggtttccttttgatttccaccgacctgaagtatgaaac atcctcaaagcagcagccaagtttccacgtatgggaaggtctgaacctgataagcagacagtggagggggaagtcagcc ccttga (SEQ ID NO: 42)
Table 18: Nucleic Acid and Polypeptide Sequences of BPIL232-6
18A: Nucleic Acid Sequences
TTGAGGACACCTTGACTAACCTCCAAGGGCAACTAAAGGATCAAGAAAGGCCCAGCACAGCAGAAGA TCAGCTGGATCTAGCTCCTGCAGGAGATGTGTACAAAGACAATCCCAGTCCTCTGGGGATGTTTCCTC CTGTGGAATCTCTATGTCTCATCCTCTCAGACCATTTACCCTGGAATCAAGGCAAGGATTACTCAGAG GGCACTTGACTATGGTGTTCAAGCTGGAATGAAGATGATTGAGCAAATGCTAAAAGAAAAGAAACTCC CAGATTTAAGCGGTTCTGAGTCTCTTGAATTTCTAAAAGTTGATTATGTAAACTACAATTTTTCAAATAT AAAAATCAGTGCCTTTTCATTTCCAAATACCTCATTGGCTTTTGTGCCTGGAGTGGGAATCAAAGCGCT AACCAACCATGGCACTGCCAACATCAGCACAGACTGGGGGTTCGAGTCTCCACTTTTTGTTCTGTATA ACTCCTTTGCTGAGCCCATGGAGAAACCCATTTTAAAGAACTTAAATGAAATGCTCTGTCCCATTATTG CAAGTGAAGTCAAAGCGCTAAATGCCAACCTCAGCACACTGGAGGTTTTAACCAAGATTGACAACTAC ACTCTGCTGGATTACTCCCTAATCAGTTCTCCAGAAATTACTGAGAACTACCTTGACCTGAACTTGAAG GGTGTATTCTACCCACTGGAAAACCTCACCGACCCCCCCTTCTCACCAGTTCCTTTTGTGCTCCCAGA ACGCAGCAACTCCATGCTCTACATTGGAATCGCCGAGTATTTCTTTAAATCTGCGTCCTTTGCTCATTT CACAGCTGGGGTTTTCAATGTCACTCTCTCCACCGAAGAGATTTCCAACCATTTTGTTCAAAACTCTCA AGGCCTTGGCAACGTGCTCTCCCGGATTGCAGAGATCTACATCTTGTCCCAGCCCTTCATGGTGAGG ATCATGGCCACAGAGCCTCCCATAATCAATCTACAACCAGGCAATTTCACCCTGGACATCCCTGCCTC CATCATGATGCTCACCCAACCCAAGAACTCCACAGTTGAAACCATCGTTTCCATGGACTTCGTTGCTA GTACCAGTGTTGGCCTGGTTATTTTGGGACAAAGACTGGTCTGCTCCTTGTCTCTGAACAGATTCCGC CTTGCTTTGCCAGAGTCCAATCGCAGCAACATTGAGGTCTTGAGGTTTGAAAATATTCTATCGTCCATT CTTCACTTTGGAGTCCTCCCACTGGCCAATGCAAAATTGCAGCAAGGATTTCCTCTGTCCAATCCACA CAAATTCTTATTCGTCAATTCAGATATTGAAGTTCTTGAGGGTTTCCTTTTGATTTCCACCGACCTGAA GTATGAAACATCCTCAAAGCAGCAGCCAAGTTTCCACGTATGGGAAGGTCTGAACCTGATAAGCAGA CAGTGGAGGGGGAAGTCAGCCCCTTGATTGCCGGTTTGCAATTCACCCCAGGAAGTAAATGGTCCTT AATCCTACAACTACTGTAAACCCAGAAGGGAAAGACAGTACACACTGGAATTGTAAAGCCCTTGTGAA TTGCTTAGGCAGAAAGTTTTCTTTCTTAAGCCTTCAGGAACCCAGAATAAGGCAGACTCTGTTAAAGG GATAAATAGAGGTGTCTGAATGTGAGTGTATGCATGCTGCGTGTGTCTGTGTTTATGTTTGTTTGTTTG TTTGGGGCAAGAAAGATTCTAGGACAAGAGCTAGGCATGTACTTCTGACCAGGTGGGTAAGCAACTC TAAGTCTGTATTTGTATTGGTCATTCTCAGTGGAAATCCCTTAGGCCCTCTAGTGGTTTTCCCCTACCT GCATATTGGTTTTCATGTTTTATATTCACTGTTACTATCTTCTGTGTTTAATTAAAATTGTTTTCTATCAA AAAAAAAAAAA (SEQ ID NO: 40) 18B: Polypeptide Sequences
MCTKTIPVL GCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYN FSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFVLYNSFAEPMEKPILKNLNEMLCPIIASEVKAL NANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGIAEYFFKS ASFAHFTAGVFNVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMM PHKFLFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHVWEGLNLISRQWRGKSAP (SEQ ID NO:.41)
The BPIL-232 encoded polypeptides have homology (approximately 59% similarity) to human BPI precursor (GenBank Ace. No. AAA51841).
A search of the NCBI CD-Search database demonstrated that BPIL 232 has significant similarity to multiple bactericidal/permeability-increasing protein superfamily domains, as shown in Table 19.
This degree of homology between a BPLI-196 polypeptide and bactericidal/permeability- increasing protein superfamily domains (both in terms of length and complexity) is very unlikely to have occurred by chance alone as represented by the Expect (E) value in Table 19.
Table 19
19 : NCBI CD-Search results for BPIL 232-1
Score E
Sequences producing significant alignments: (bits) value gnllPfam|pfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 164 le-41 gnllSmartlBPI2 BPI/LBP/CETP C-terminal domain; Bactericidal permeability-incr... 113 3e-26 gnllSmartlBPIl BPI LBP/CETP N-terminal domain; Bactericidal permeability-incr... 105 5e-24
19B: NCBI CD-Search results for BPIL 232-2
Score E
Sequences producing significant alignments: (bits) value gnliPfamjpfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 161 le-40 gnl|Smart|BPI2 BPI/LBP/CETP C-terminal domain; Bactericidal permeability-incr.. 109 3e-25 gnllSmartlBPIl BPI/LBP/CETP N-terminal domain; Bactericidal permeability-incr.. 105 5e-24
19C: NCBI CD-Search results for BPIL 232-3
Score E
Sequences producing significant alignments: (bits) value gnllPfam|pfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 169 2e-43 gnllSmart|BPI2 BPI/LBP/CETP C-terminal domain; Bactericidal permeability-incr.. 1 17 2e-27 gnllSmartlBPIl BPI LBP/CETP N-terminal domain; Bactericidal permeability-incr.. 105 5e-24
19D: NCBI CD-Search results for BPIL 232-4 Score E
Sequences producing significant alignments: (bits) value
GnllSmartlBPI2 BPI LBP/CETP C-terminal domain; Bactericidal permeability-incr.. 120 le-28 gnllPfamlpfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 113 2e-26 gnllPfamlpfam01273 LBP BPI CETP, LBP / BPI / CETP family 56.2 4e-09 gnllSmartlBPIl BPI/LBP/CETP N-terminal domain; Bactericidal permeability-incr.. 64.0 2e-l l
19E: NCBI CD-Search results for BPIL 232-5
Score E
Sequences producing significant alignments: (bits) value enllPfamlpfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 173 3e-44 gnllSmart|BPI2 BPI/LBP/CETP C-terminal domain; Bactericidal permeability-incr.. 120 le-28 gnllSmartlBPIl BPI/LBP/CETP N-terminal domain; Bactericidal permeability-incr.. 105 5e-24
19E: NCBI CD-Search results for BPIL 232-6
Score E
Sequences producing significant alignments: (bits) value gnllSmartlBPI2 BPI/LBP/CETP C-terminal domain; Bacteπcidal permeability-incr... 117 le-27 gnllPfam|ρfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 1 10 2e-25 gnllPfam|pfam01273 LBPJ3PI_CETP, LBP / BPI / CETP family 56.2 4e-09 gnllSmartlBPIl BPI/LBP/CETP N-terminal domain; Bactericidal permeability-incr... 64.0 2e-l l
CD multiple alignments of the bactericidal/permeability-increasing protein superfamily domains are presented in Table 20. Black outlined amino acids indicates identity, whereas grey outlined amino acids indicates conservative substitution. Based on its relatedness, the BPIL-232 proteins are novel members of the bactericidal/permeability-increasing protein superfamily.
Table 20:
20A. Alignment of BPIL 232 with the BPI/LBP/CETP family domain
-ESCEF
Figure imgf000042_0001
70 80 90 100 110 120
232 1 |J ^DYVNg^smκgSA] SFjJSraSEAFVgG giKALTNHGTAN|jSTDgGFESP LFQD
Figure imgf000043_0001
232 E PMraKPILKNJBBEMIHPII - -jjNANJJS 232 gi|7 97995 hypothetical protei JTI jKKXfRKYIDEDANEKLAEAQTSSI ETNALKMISVGGDEKS gij 1709662 PHOSPHOLIPID TRANSF TFITSGMRFIΛHQQI [SI gij 2822120 BACTERICIDAL PERMEA KKΪ[3SALRNK!!JSQ| E VΓ FOQPPYYFFQQ- gij 115110 BACTERICIDAL PERMEAB KRlHsLLQKSMTRKI IQPYFQ- Consensus
Figure imgf000043_0002
380 390 400 410 420 A. AA |....|....|....|
232 1 ra-rerci-πgππ. 232 2 ^LSRIAEIYILSQPFMVRIMATEPPII LQPGNBFTLD
Figure imgf000044_0001
232 (Seq ID No: 79) 232 (Seq ID NO: 80) 232 LKY (Seq ID NO: 81) 232 LKY (Seq ID No: 82) 232 LKY (Seq ID No: 83) 232 LKY (Seq ID NO: 84) gi I 7497995 hypothetical protei (Seq ID NO: 85) gij 1709662 PHOSPHOLIPID TRANSF (Seq ID NO: 86) gij 2822120 BACTERICIDAL PERMEA (Seq ID No: 87) gij 115110 BACTERICIDAL PERMEAB (Seq ID NO: 88) Consensus (Seq ID NO: 202)
20B. Alignment of BPIL 232 with the BPI/LBP/CETP C-terminal domain
Figure imgf000044_0002
70 80 90 100 110 120
| . . . . | . • • I
Figure imgf000045_0001
20C. Alignment of BPIL 232 with the BPI/LBP/CETP N-terminal domain
Figure imgf000045_0002
Figure imgf000046_0001
20D. Alignment of BPIL 232-2 and 232-4 with the BPI/LBP/CETP C-family domain
Figure imgf000046_0002
130 140 150 160 170 180
232 4
232 6 gi I 7497995 hypothetical protei QVEILA^^ΪFHLESSIEKGK-NgSAKOTSI^LATlRDVTVTNHNGGLFGLAVSVFKQG qi 1 1709662 PHOSPHOLIPID TRANSF YINASAE^SIRTGLELiSRDP-A@RMKVS vfflQAsVsRMHAAFGG- -TFKKVYDFLSTF gi I 2822120 BACTERICIDAL PERMEA NFDLSIEgrølSADLKjteSNPTSgKPTITCSgSSHlNSJJΗVHISKS-KVGWLIQLFHKK gi j 115110 BACTERICIDAL PERMEAB FD SV^^IIAGLN^ DPAS^Sl 2csHSlGJNTϊRIHI SGS " SLGWLIQLFRKR Consensus
190 210 220 230 240
. . | . .
232 4 232 6 gi I 7497995 hypothetical protei VSDNyRHMEQTIlB Kl^RKYIDEDANEKLAEAQTSSK Kljll;AD A.LEjjNALKMISVGGDEKSRI gi 11709662 PHOSPHOLIPID TRANSF αTSGMRFLLNQQIj PVLYH AGTVl LfJNS S:LLDΠ γ gij 2822120 BACTERICIDAL PERMEA iESALRNKMNSQV j EKVTN SVSS KI IQQPPYFQB li gij 115110 BACTERICIDAL PERMEAB IESLLQKSMTRKI j -TVSSKgQ D.PYFC Consensus
260 270 280 290 300
232 4
Figure imgf000047_0001
onsensus
310 330 340 350 360
232 4 232 6 gi I 7497995 hypothetical protei SPFKTNWDSV- TNKDSKEEV 'fjLPNSLLYHAYVQRFIKyi PRTKGVSSFLRTT gi | 1709662 PHOSPHOLIPID TRANSF -LPNRAVEPQL- -QEEERS Y^AF ESFFDSAMESYFRAGAIIQL: 'GDKVPHDLDML-- gi | 2822120 BACTERICIDAL PERMEA -PFAPPVMEFP- -AAHDRj </YLGL ΎFFNTAGLVYQEAGVLKMT 'RDDMIPKESKFR-- gi j ll5110 BACTERICIDAL PERMEAB - PFAPPALAFP- -SDHD j VYEGIJ YFFNTAGFVYQKAGALNLT RDDMIPKESKFR-- Consensus
370 380 390 400 410 420
..|.. •■I
232 4 232 6 gi I 7497995 hypothetical protei CEGSFCISDLAPQIAEQYPNSTyEIiAMSATRAl LFSEKNGGTISVSLGGLVWFAVNG gij 1709662 PHOSPHOLIPID TRANSF - LRATYFG - S I VLES'PAVIDSPLKLEERVLAP SRCTIKPS -GTTISVTAS - -VTIALVPP gi I 2822120 BACTERICIDAL PERMEA -LTTKFFGTFLPEyAKKFPNMKIQIH\rSASTPBHLSVQPT-GLTFYPAVD- -VQAFA\ξLP gij 115110 BACTERICIDAL PERMEAB -LTTKFFGILIPQyAKMFpBMQMQliFIWASLPgKLTMKPS-SLDLIFVLD- -TQAFAILP Consensus
430 440 450 460
232 4 232 6 gi 17497995 hypothetical protei NQ- -RRQVIVTO jDVVADARπsiQGHNVSGS^EgRKFDLKRRTGT^DISDAEIDDIAE gij 1709662 PHOSPHOLIPID TRANSF DQ- PEVQp_lSSMTMDARLSAKMALRGKALRTQLD[j RRFRIYSNHSALESLALIPLQAPLKT gij 2822120 BACTERICIDAL PERMEA NS - SLASllFLlGMHTTGSMEy SAESNRllvGEώ -RLLLELKHSNIGPFPVELLQDIMNY gi 1115110 BACTERICIDAL PERMEAB yS-SLDPliFLΪJEHNLNLSWVGAKSDRLIGEiiF DKLLL'ELKHSDΪGPFSVESLQSVΪNY Consensus
490 500 510 520 530
232 4 (Seq ID No : 112 )
Figure imgf000047_0002
BPIL-232 polypeptides were also modeled using the crystal structure of human bactericidal/permeability increasing protein ("BPI") (Beamer et al. Science 276, 1997) using GeneAtlas software. The models demonstrated tertiary structure similar to BPI. Specifically, the BPIL-232 protein structure has the characteristic boomerang-shape with two domains of other members of the bactericidal/permeability-increasing protein superfamily.
Structural overlays of the molecular model of BPIL-232 against BPI using the program Profϊle-3D were performed. Profile 3-D is a threading program which measures the compatibility of the protein model with its sequence using a 3-D profile. Using defined parameters Profile 3-D computes a verify score for the model. A verify score between 0 and 1 correlates to a good model. A verify score under 0 correlates to a bad model.
The following verify scores were obtained for each of the BPIL-232 polypetides:
Table 21
Figure imgf000048_0001
The above described models confirm that the BPIL-232 polypeptides retain tertiary structural homology with the BPI superfamily.
In addition, primary sequence structural alignments were also performed. Tables 22-27 illustrate the primary sequence alignment with secondary structures of BPI. As illustrated in Tables 22-27 all the BPIL-232 polypeptides have the conserved cysteine residues that are involved in disulfide bond formation between the final strand of the beta sheet and the long alpha helix. Consistent with the conserved teriary structure, Tables 22-27 also illustrate that much of the amino acids in regions of secondary structure are conserved between BPIL-232 and BPI.
Table 22: Primary Sequence Alignment of BPIL 232-1 with Secondary Structure of BPI
>HHHHHHHHHHHHHHHHHHHHH >
Sbj ct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKH GKGH- -YSFYSMDI 58
+ PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSES EFLKVDYVNYNFSNIKI 85 Sbjct 59 REFQLPSSQISMVPNVG KFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + + Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIII 145
S δ > > HHHHHHHHHH-HHHHHHHHHHHHHHHH
Sbjct 119 GSNPTSGKPTITCSSCSSHINSVHVHISKSKVG LIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + +4- HV S ++ F + +E + +N +C + Query 146 TRND-FGHPTLKLQDCYAQ SHAHVSFS-GE SVLYNSF.VEPMEKPILKN NEMLCPII 203
HHHHHH HHHHH --> > >
Sbjct: 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
: + V TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP Query: 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262 >HHHHHHHHHHHHH > HHHH
Sbjct: 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
: F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++ Query: 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
HHHH HHHH > >
Sbjct: 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTG TFYPAVDVQAFAVLPNSA ASIiF 357
: G L +A+ + + + + A+ PP +++QP T + NS + ++ Query: 321 GNV SRIAEIYILSQPFMVRIMATEPPIINLQPGNFT DIPASIMM TQPKNSTVETIVS 380 > HHHHHHHHHHHHHHH-HHHH
Sbjct: 358 IG HTTGSMEVSAESNR VGE KLDR ELKHSNIGPFPVELLQDIMNYIVPI V PRV 417
: + + S+ + RLV L L+R L L SN V ++I++ 1+ V P Query: 381 MDFVASTSVGLVI GQRLVCS SLNRFRLALPESNRSNIEV RFENILSSILHFGV PLA 440
HHHHHH- > >
Sbj ct : 418 NEKLQKGFPIiPTPARVQIiYNWLQPHQNF 448 (Seq ID No: 119)
: N K Q+GFPLP P + N ++ + +
Query : 441 NAKLQQGFPLPNPHKFLFVNSDIEVLEVRMQ 471 (Seq ID No: 120)
KEY: H = denotes alpha helix secondary structure > = denotes beta-strand secondary structure (variable amounts of hyphens . H-H = one residue breaks in an alpha helix structure S S = disulfide bond
NOTE: Residues 17-45, 82-108, and 142-169 of BPI (public) are considered critical for LPS-binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.276 20JUNE 1997pl861).
Table 23: Primary Sequence Alignment of BPIL 232-2 with Secondary Structure of BPI
>HHHHHHHHHHHHHHHHHHHHH > Sbj ct : 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH- -YSFYSMDI 58
: + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query: 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDIiSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS + + +G DL + G+ + + Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTD GFESPLFQDTGGADLFLSGVYFTGIII 145 s s > > HHHHHHHHHH-HHHHHHHHHHHHHHHH
Sbjct: 119 LGSNPTSGKPTITCSSCSSHINSTOVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178 : L N G PT+ C + ++ HV S ++ L F + +E + +N +C +
Query: 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCPII 203
HHHHHH HHHHH --> > >
Sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V L T V+TKID+ ++Y L++ P T LD+ +KG FY + PP Query 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262 >HHHHHHHHHHHHH > HHHH
Sbjct: 239 FAPPV EFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298 : F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query: 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
HHHH HHHH > >
Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++ Query 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380 > HHHHHHHHHHHHHHH-HHHH
Sbjct: 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417 : + + S+ + RLV L L+R L L SN V ++I++ 1+ VLP
Query: 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440
HHHHHH- > >
Sbjct: 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLL 448 (Seq ID No: 121) : N KLQ+GFPL P + N ++ + +
Query: 441 NAKLQQGFPLSNPHKFLFVNSDIEVLEVRMQ 471 (Seq ID No: 122)
KEY: H = denotes alpha helix secondary structure > = denotes beta- strand secondary structure (variable amounts of hyphens . H-H = one residue breaks in an alpha helix structure
S S = disulfide bond
NOTE : Residues 17 -45 , 82 - 108 , and 142 -169 of BPI (public) are considered critical for LPS-binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.276 2o JUNE 1997 l86l).
Table 24: Primary Sequence Alignment of BPIL 232-3 with Secondary Structure of BPI >HHHHHHHHHHHHHHHHHHHHH >
Sbj ct : 1 VNPGVWRISQKGLDYASQQGTAALQKΕLKRIKIPDYSDSFKIKHLGKGH- -YSFYSMDI 58
+ PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query : 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85 Sbjct: 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + + Query: 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIII 145
> > HHHHHHHHHH-HHHHHHHHHHHHHHHH
Sbjct: 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + ++ HV S ++ L F + +E + +N +C + Query: 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCPII 203
HHHHHH HHHHH --> > >
Sbjct: 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238 + V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP Query: 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262 >HHHHHHHHHHHHH > HHHH
Sbjct: 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298 F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++ Query: 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
HHHH HHHH > >
Sbjct: 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357 G L +A+ + + + + A+ PP +++QP T + NS + ++ Query: 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380 > HHHHHHHHHHHHHHH-HHHH
Sbjct: 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417 + + S+ + RLV L L+R L L SN V ++I++ 1+ VLP Query: 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440
HHHHHH-> > >
Sbjct: 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADVVYK 456 (Seq ID No: 123)
N KLQ+GFPL P + N ++ + FLL D+ Y+ Query: 441 NAKLQQGFPLSNPHKFLFVNSDIEVLEGFLLISTDLKYE 479 (Seq ID No: 124)
KEY: H = denotes alpha helix secondary structure > = denotes beta-strand secondary structure (variable amounts of hyphens .
H-H = one residue breaks in an alpha helix structure
S S = disulfide bond
NOTE: Residues 17-45, 82-108, and 142-169 of BPI (public) are considered critical for LPS-binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.276 20JUNE 1997p!86l).
Table 25: Primary Sequence Alignment ofBPIL 232-4 with Secondary Structure ofBPI >HHHHHHHHHHHHHHHHHHHHH > Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct: 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118 : F P++ ++ VP VG+K ++ I Query: 86 SAFSFPNTSLAFVPGVGIKALTNHGTANI- 114 > > HHHHHHHHHH-HHHHHHHHHHHHHHHH
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
S S + L F + +E + +N +C + Query 115 STDWGFESP LFVLYNSFAEPMEKPILKNLNEMLCPII 151
HHHHHH HHHHH --> > > sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V + L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP Query 152 ASEVKA-LNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 210 >HHHHHHHHHHHHH > HHHH
Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++ Query 211 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 268
HHHH HHHH > >
Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++ Query 269 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 328 > HHHHHHHHHHHHHHH-HHHH
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
+ + S+ + RLV L L+R L L SN V ++I++ 1+ VLP Query 329 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 388
HHHHHH- > > >
Sbjct 18 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No: 125)
N KLQ+GFPLP P + N ++ + FLL D+ Y+ Query 389 NAKLQQGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 427 (Seq ID No: 126)
KEY: H = denotes alpha helix secondary structure > = denotes beta-strand secondary structure (variable amounts of hyphens . H-H = one residue breaks in an alpha helix structure S S = disulfide bond
NOTE: Residues 17-45, 82-108, and 142-169 of BPI (public) are considered critical for LPS-binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.27620JUNE 1997pi861).
Table 26: Primary Sequence Alignment ofBPIL 232-5 with Secondary Structure ofBPI >HHHHHHHHHHHHHHHHHHHHH >
Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH- -YSFYSMDI 58
+ PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85 > >
Sbjct 59 REFQLPSSQISI PNVGLKFSISNANIKISGKWKAQKRFLK SGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + + Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIII 145 > > HHHHHHHHHH-HHHHHHHHHHHHHHHH
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVG LIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + ++ HV S ++ L F + +E + +N 4-C +
Query 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCPII 203
HHHHHH HHHHH --> > >
Sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP
Query 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262 >HHHHHHHHHHHHH > HHHH
Sbjct: 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
: F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++ Query: 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
HHHH HHHH > >
Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++
Query 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380 > HHHHHHHHHHHHHHH-HHHH
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
+ + S+ + RLV L L+R L L SN V ++I++ 1+ VLP
Query 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440
HHHHHH- > > >
Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No: 127)
N KLQ+GFPLP P + N ++ + FLL D+ Y+
Query 441 NAKLQQGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 479 (Seq ID No: 128)
KEY: H = denotes alpha helix secondary structure > = denotes beta-strand secondary structure (variable amounts of hyphens . H-H = one residue breaks in an alpha helix structure S S = disulfide bond NOTE: Residues 17-45, 82-108, and 142-169 of BPI (public) are considered critical for LPS-binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.276 20JUNE 1997pl86l).
In the tables below, the subject line represents the BPI sequence and the query line represents the BPILX sequence.
Table 27: Primary Sequence Alignment of BPIL 232-6 with Secondary Structure of BPI >HHHHHHHHHHHHHHHHHHHHH > Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH- -YSFYSMDI 58
+ PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85 Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGK KAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ I Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANI 114 > HHHHHHHHHH-HHHHHHHHHHHHHHHH
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
S S + L F + +E + +N +C + Query 115 STDWGFESP LFVLYNSFAEPMEKPILKNLNEMLCPII 151
HHHHHH HHHHH --> > >
Sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V + L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP Query 152 ASEVKA-LNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 210 >HHHHHHHHHHHHH > HHHH
Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++ Query 211 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 268
HHHH HHHH > >
Sbjct: 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++ Query: 269 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 328 > HHHHHHHHHHHHHHH-HHHH
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
+ + S+ + RLV L L+R L L SN V ++I++ 1+ VLP Query 329 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 388
HHHHHH- > > >
Sbjct 418 NEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADWYK 456
N KLQ+GFPL P + N ++ + FLL D+ Y+ Query 389 NAKLQQGFPLSNPHKFLFVNSDIEVLEGFLLISTDLKYE 427
KEY: H = denotes alpha helix secondary structure > = denotes beta-strand secondary structure (variable amounts of hyphens .
H-H = one residue breaks in an alpha helix structure S S = disulfide bond
NOTE : Residues 17 -45 , 82 -108 , and 142 -169 of BPI (public) are considered critical for LPS-binding , LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL.276 20 JUNE 1997 p 86l).
Primary sequence alignments within 4 A of the carboxy and amino terminal binding pocket were also performed and are illustrated in Tables 28 -39. Amino acids that are underlined in Table 28 -39 represent amino acids are comprise the binding pocket. By "binding pocket" is meant to be the site where a BPILX ligand interacts ( e.g. charge interaction, hydrophobic forces, van der Waals attraction, hydrogen bonding, dipole interactionn and entropy increases) with a BPILX polypeptide. In tables 28-39 below, the BPILX sequence of the present invention is the Query and the BPI known sequence is the Subject.
Table 28: BPIL 232-1 N-terminal binding pocket
Sbjct 1 VNPGV RISQKGLDYASQ2GTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I
Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
10 F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + + Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGI.il 145
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + ++ HV S ++ L F + +E + +N +C +
15 Query 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNΞFAEPMEKPILKNLNEMLCPII 203
Sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP
Query 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262
2 ?0o
Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
25 Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++
Query 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
30 + + S+ + RLV L L+R L L SN V ++I++ 1+ VLP Query 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440
Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLL 448 (Seq ID No: 129)
N KLQ+GFPLP P + N ++ + + 35 Query 441 NAKLQQGFPLPNPHKFLFVNSDIEVLEVRMQ 471 (Seq ID No: 130)
Table 29: BPIL 232-1 C-terminal binding pocket
Sbj ct 1 VNPGWVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58
40 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I
Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbj ct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + + 45 Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIII 145
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + ++ HV S ++ L F + +E + +N +C + Query 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCP11 203
50
SbjCt: 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238 : + V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP Query 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262 Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++ Query 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320 Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++ Query 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380 Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417 + + S+ + RLV L L+R L L SN V ++I++ 1+ VLP Query 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440 Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLL 448 (Seq ID No: 131)
N KLQ+GFPLP P + N ++ + + Query 441 NAKLQQGFPLPNPHKFLFVNSDIEVLEVRMQ 471 (Seq ID No: 132)
Table 30: BPIL 232-2 N-terminal binding pocket
Sbjct 1 VNPGV RISQKGLDYASQ2GTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I
Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + +
Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGI.il 145
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + ++ HV S ++ L F + +E + +N +C +
Query 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCPII 203
Sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP
Query 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262
Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++
Query 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
+ + S+ + RLV L L+R L L SN V ++I++ 1+ VLP
Query 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440
Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLL 448 ( Seq ID No : 133 )
N KLQ+GFPL P + N ++ + +
Query 441 NAKLQQGFPLSNPHKFLFVNSDIEVLEVRMQ 471 ( Seq ID No : 134 )
Table 31: BPIL 232-2 C-terminal binding pocket Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I
Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + +
Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIII 145 Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + ++ HV S ++ L F + +E + +N +C +
Query 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCPII 203
Sbjct 179 TNSVSSKLOPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP Query 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262
Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++
Query 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380 Sbjct 358 IG HTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILyLPRV 417 + + S+ + RLV L L+R L L SN V ++I++ 1+ VLP
Query 381 DFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440
Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLL 448 (Seq ID No: 131)
N KLQ+GFPL P + N ++ + +
Query 441 NAKLQQGFPLSNPHKFLFVNSDIEVLEVRMQ 471 (Seq ID No: 131)
Table 32: BPIL 232-3 N-terminal binding pocket
sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58
+ PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query 26 IYPGIKARITQRALDYGVOAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLK SGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ I
Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANI — 114
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
S S + L F + +E + +N +C + Query 115 j STDWGFESP LFVLYNSFAEPMEKPILKNLNEMLCPII 151
Sbjct 179 TNSVSSIOiQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V + L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP
Query 152 ASEVKA-LNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 210
Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query 211 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 268 Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357 : G L +A+ + + + + A+ PP +++QP T + NS + ++ Query: 269 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 328
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
+ + S+ + RLV L L+R L L SN V ++I++ 1+ VLP
Query 329 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 388
Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No: 137)
N KLQ+GFPLP P + N ++ + FLL D+ Y+ Query 389 NAKLQOGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 427 (Seq ID No: 138)
Table 33: BPIL 232-3 C-terminal binding pocket
Sbjct: 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I
Query: 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + +
Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIII 145
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + ++ HV S ++ L F + +E + +N +C +
Query 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCPII 203
Sbjct: 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238 + V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP
Query: 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262
Sbjct: 239 FAPPV EFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLK TLRDDMIPKESKFRLTTKFF 298 F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query: 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS - -NHFVQNSQGL 320
Sbjct: 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357 G L +A+ + + + + A+ PP +++QP T + NS + ++
Query: 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380
Sbjct: 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRY 417 + + S+ + RLV L L+R L L SN V ++I++ 1+ VLP
Query: 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440
Sbjct: 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No: 139) N KLQ+GFPL P + N ++ + FLL D+ Y+ Query: 441 NAKLQQGFPLSNPHKFLFVNSDIEVLEGFLLISTDLKYE 479 (Seq ID No : 140)
Table 34: BPIL 232-4 N-terminal binding pocket
Sbjct: 1 'VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58 : + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query: 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + +
Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIII 145
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + ++ HV S ++ L F + +E + +N +C +
Query 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCPII 203
Sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP
Query 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262 Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++
Query 321 GNVLSRIAEIYILSQPFMVRI ATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417 + + S+ + RLV L L+R L L SN V ++I++ 1+ VLP Query 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440
Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 ( Seq ID No : 141 )
N KLQ+GFPLP P + N ++ + FLL D+ Y+
Query 441 NAKLQQGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 479 ( Seq ID No : 142 )
Table 35: BPIL 232-4 C-terminal binding pocket
Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58
+ PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I
Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ I
Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANI 114
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
S S + L F + +E + +N +C +
Query 115 STDWGFESP LFVLYNSFAEPMEKPILKNLNEMLCPII 151
Sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V + L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP
Query 152 ASEVKA-LNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 210
Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query 211 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS - -NHFVQNSQGL 268
Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++
Query 269 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 328 Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
+ + S+ + RLV L L+R L L SN V ++I++ 1+ VLP Query 329 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 388 Sbjct 418 NEKLOKGFPLPTPARVOLYNWLQPHQNFLLFGADWYK 456 (Seq ID No: 143)
N KLQ+GFPLP P + N ++ + FLL D+ Y+ Query 389 NAKLQQGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 427 (Seq ID No: 144)
Table 36: BPIL 232-5 N-terminal binding pocket
Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I
Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + +
Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIII 145
Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
L N G PT+ C + ++ HV S ++ L F + +E + +N +C +
Query 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCPII 203
Sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP
Query 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262
Sbjct 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSAΞTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++
Query 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417 + + S+ + RLV L L+R L L SN V ++I++ 1+ VLP
Query 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440
Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No: 145)
N KLQ+GFPLP P + N ++ + FLL D+ Y+
Query 441 NAKLQOGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 479 (Seq ID No : 146)
Table 37: BPIL 232-5 C-terminal binding pocket
Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58
+ PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85
Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ IS W + + +G DL + G+ + + Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIII 145 Sbjct: 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178 L N G PT+ C + ++ HV S ++ L F + +E + +N +C +
Query: 146 LTRND-FGHPTLKLQDCYAQLSHAHVSFS-GELSVLYNSFAEPMEKPILKNLNEMLCPII 203
Sbjct: 179 TNSVSSKLQPYFQTLPWTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
: + V L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP Query: 204 ASEVK-ALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 262
Sbjct: 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
: F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++ Query: 263 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 320
Sbjct: 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
: G L +A+ + + + + A+ PP +++QP T + NS + ++ Query: 321 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 380
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
+ + S+ + RLV L L+R L L SN V ++I++ 1+ VLP Query 381 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 440 Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456 (Seq ID No: 147)
N KLQ+GFPLP P + N ++ + FLL D+ Y+ Query 441 NAKLQQGFPLPNPHKFLFVNSDIEVLEGFLLISTDLKYE 479 (Seq ID No: 148)
Table 38: BPIL 232-6 N-terminal binding pocket Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH- -YSFYSMDI 58 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I
Query 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKI 85 Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ I Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANI 114
Sbjct: 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
: S S + L F + +E + +N +C +
Query: 115 , STDWGFESP LFVLYNSFAEPMEKPILKNLNEMLCPII 151
Sbjct: 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
: + V + L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP
Query: 152 ASEVKA-LNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 210
Sbjct: 239 FAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
: F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++
Query: 211 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 268
Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357
G L +A+ + + + + A+ PP +++QP T + NS + ++ Query 269 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVS 328
Sbjct: 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
: + + S+ + RLV L L+R L L SN V ++I++ 1+ VLP
Query: 329 DFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 388
Sbjct: 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456
: N KLQ+GFPL P + N ++ + FLL D+ Y+
Query: 389 NAKLQQGFPLSNPHKFLFVNSDIEVLEGFLLISTDLKYE 427 NOTE: Residues 17-45, 82-108, and 142-169 of BPI (public) are considered critical for LPS-binding, LPS-neutralizing, and bactericidal activity, according to Beamer et al . (Science Vol. 276 20 June 1997 pl861) .
Table 39: BPIL 232-6 C-terminal binding pocket
Sbjct: 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGH--YSFYSMDI 58 + PG+ RI+Q+ LDY Q G +++ LK K+PD S S ++ L + Y+F ++ I Query: 26 IYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYλ/NYNFSNIKI 85 Sbjct 59 REFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMΞGNFDLSIEGMSISADLK 118
F P++ ++ VP VG+K ++ I
Query 86 SAFSFPNTSLAFVPGVGIKALTNHGTANI 114 Sbjct 119 LGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKV 178
S S + L F + +E + +N +C + Query 115 STDWGFESP LFVLYNSFAEPMEKPILKNLNEMLCPII 151 Sbjct 179 TNSVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPP 238
+ V + L TL V+TKID+ ++Y L++ P T LD+ +KG FY + PP Query 152 ASEVKA-LNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPP 210 Sbjct 239 FAPPV EFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFF 298
F+P P + M+Y+G+++YFF +A + AGV +TL + 1 + F ++ Query 211 FSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEIS- -NHFVQNSQGL 268 Sbjct 299 GTFLPEVAKKFP-NMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALASLFL 357 G L +A+ + + + + A+ PP +++QP T + NS + ++ Query 269 GNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASI MLTQPKNSTVETIVS 328 Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
+ + S+ + RLV L L+R L L SN V ++I++ 1+ VLP Query 329 MDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLA 388 Sbjct 418 NEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGADWYK 456
N KLQ+GFPL P + N ++ + FLL D+ Y+ Query 389 NAKLQQGFPLSNPHKFLFVNSDIEVLEGFLLISTDLKYE 427
NOTE: Residues 17-45, 82-108, and 142-169 of BPI (public) are considered critical for LPS-binding, LPS-neutralizing, and bactericidal activity, according to Beamer et al . (Science Vol. 276 20 June 1997 pl861) .
BPIL-325 Genes
Four novel BPIL-325 genes were identified, BPIL-325-1 , BPIL-325-2, BPIL-325-3, and
BPIL-325-4 (hereinafter referred to collectively as "BPIL-325"). A BPIL-325-1 nucleic acid and its encoded polypeptide include the sequences shown in Table 40, whereas a BPIL-325-2 nucleic acid and its encoded polypeptide include the sequences shown in Table 41. A BPIL-325-3 nucleic acid and its encoded polypeptide include the sequences shown in Table 42. A BPIL-325-4 nucleic acid and its encoded polypeptide include the sequences shown in Table 43. The disclosed BPIL-325-1 nucleic acid (SEQ ID NO: 9) contains a 327 nucleotide open reading frame (ORF, SEQ ID NO: 15). The representative ORF includes a 109 amino acid polypeptide (SEQ ID NO: 10).
The disclosed BPIL-325-2 nucleic acid (SEQ ID NO: 33) contains a 450 nucleotide open reading frame (ORF, SEQ ID NO: 34). The representative ORF includes a 150 amino acid polypeptide (SEQ ID NO: 32).
The disclosed BPIL-325-3 nucleic acid (SEQ ID NO: 36) contains a 1362 nucleotide open reading frame (ORF, SEQ ID NO: 35) that begins with an ATG initiation codon at nucleotides 1-3. The representative ORF includes a 454 amino acid polypeptide (SEQ ID NO: 35). The program Signal D, predicts a signal peptidase cleavage site between amino acids 1 and 23.
The disclosed BPIL-325-4 nucleic acid (SEQ ID NO: 44) contains a 1362 nucleotide open reading frame that encodes an amino acid polypeptide (SEQ ID NO: 45). The program Neural Network SignalP, predicts a signal peptidase cleavage site between amino acids 16 and 17. Analysis of the BPIL-325-4 and BPIL-325-3 sequences identified that the nucleotides GTG after C97 was missing in the BPIL-325-4 sequence. This results in an amino acid change of Gin to Val after Asn32 instead of Arg-Glu as in BPIL-325-3.
Table 40: 325-1 Nucleic Acid and Polypeptide Sequences cggacgcgtg ggtcgcccac gcgtccggtg agctgccccc acaaaccacc aagaccctgg 60 ctcgcttcat tcctgaagtg gctgtagctt atcccaagtc aaagcccttg acgacccaga 120 tcaagataaa gaagcctccc aaggtcact atg aag aca ggc aag age ctg ctg 173
Met Lys Thr Gly Lys Ser Leu Leu 1 5 cac etc cac age ace ctg gag atg ttc gca get egg tgg egg age aag 221
His Leu His Ser Thr Leu Glu Met Phe Ala Ala Arg Trp Arg Ser Lys 10 15 20 get cca atg tec etc ttt etc eta gaa gtg cac ttc aat ctg aag gtc 269 Ala Pro Met Ser Leu Phe Leu Leu Glu Val His Phe Asn Leu Lys Val
25 30 35 40 cag tac tea gtg cat gag aac cag ctg cag atg gcc act tct ttg gac 317
Gin Tyr Ser Val His Glu Asn Gin Leu Gin Met Ala Thr Ser Leu Asp 45 50 55 agg aga ggg aat taactggctt catcaccagc tatctcgaag agcctacatc 369
Arg Arg Gly Asn (SEQ ID NO : 10 ) 60 ccagttgtca atgatgtgct ttcagtgggc t (SEQ ID NO: 9) 400 40A: Open Reading Frame atg aag aca ggc aag age ctg ctg cac etc cac age ace ctg gag atg 48 Met Lys Thr Gly Lys Ser Leu Leu His Leu His Ser Thr Leu Glu Met 1 5 10 15 ttc gca get egg tgg egg age aag get cca atg tec etc ttt etc eta 96 Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met Ser Leu Phe Leu Leu
20 25 30 gaa gtg cac ttc aat ctg aag gtc cag tac tea gtg cat gag aac cag 144 Glu Val His Phe Asn Leu Lys Val Gin Tyr Ser Val His Glu Asn Gin 35 40 45 ctg cag atg gcc act tct ttg gac agg aga ggg aat (Seq ID No: 15) 180
Leu Gin Met Ala Thr Ser Leu Asp Arg Arg Gly Asn (Seq ID No: 10)
50 55 60
Table 41: BPIL 325-2 nucleic acid and polypeptide sequences
41 A: Nucleic Acid Sequences
CAAGCTTGCTGATGCCGGGGAGGCCCTCACGTTCCCTGAGGGTTATGCCAAAGGCTCGTCGCAGC TGCTGCTCCCAGCCACCTTCCTCTCTGCAGAGCTTGCCCTTCTGCAGAAGTCCTTTCATGTGAATAT CCAGGATACAATGATTGGTGAGCTGCCCCCACAAACCACCAAGACCCTGGCTCGCTTCATTCCTGA
AGTGGCTGTAGCTTATCCCAAGTCAAAGCCCTTGACGACCCAGATCAAGATAAAGAAGCCTCCCAAG GTCACTATGAAGACAGGCAAGAGCCTGCTGCACCTCCACAGCACCCTGGAGATGTTCGCAGCTCGG TGGCGGAGCAAGGCTCCAATGTCCCTCTTTCTCCTAGAAGTGCACTTCAATCTGAAGGTCCAGTACT CAGTGCATGAGAACCAGCTGCAGATGGCCACTTCTTTGGACAGGAGAGGGAATTAACTGGCTTCATC ACCAGCTATCTCGAAGAAGCCTACATCCCAGTTGTCAATGATGTGCTTCAAGTGGGGCTCCCACTCC
CGGACTTTCTGGCCATGAATTACAACCTGGCTGAGCTGGACATAGTAGAGAATGCCCTGATGCTGGA CTTGAAGCTGGGCTGACCATGGCAGGACTCCCCTGCCAGCTGCCTGCTTACCACCAACCACCTGCA CCCCATGGAGGAGACCCCCTGATTGGAGCCAGGTGGGCCTGGCCCCCTACCACTGGTGGCTGCCT CCTTTGACAAGGAGTGAATGGGTCANGCCTGGGCTGGAGCCTTGCCAATAAACAGGAGAAAGGCTC TTATAAATATCTGAAAAAAAAAAAAAA (Seq ID No: 33)
41B: Polypeptide Sequences
KLADAGEALTFPEGYAKGSSQLLLPATFLSAELALLQKSFHVNIQDTMIGELPPQTTKTLARFIPEVAVAY PKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFLLEVHFNLKVQYSVHENQLQM
ATSLDRRGN (Seq ID No: 32)
Table 42: BPIL 325-3 nucleic acid and polypeptide sequences 42A: Nucleic Acid Sequences
atgctgcggatcctgtgcctggcactctgcagcctgctgactggcacgcgagctgaccctggggcactgctgcggttgg gcatggacatcatgaaccgtgaggtccagagcgccatggatgagagtcatatcctggagaagatggcagccgaggcagg caagaaacagccagggatgaaacctatcaagggcatcaccaatttgaaggtgaaggatgtccagctgcccgtcatcaca ctgaactttgtacctggagtgggcatcttccaatgtgtgtccacaggcatgaccgtcactggcaagagcttcatgggag ggaacatggagatcatcgtggccctgaacatcacagccaccaaccggcttctgcgggatgaggagacaggcctccccgt gttcaagagtgagggctgtgaggtcatcctggtcaatgtgaagactaacctgcctagcaacatgcttcc gtggtgcag cagcaaaagggcaaaaccatcaagcttgctgatgccggggaggccctcacgttccctgagggttatgccaaaggctcgt cgcagctgctgctcccagccaccttcctctctgcagagcttgcccttctgcagaagtcctttcatgtgaatatccagga tacaatgattggtgagctgcccccacaaaccaccaagaccctggctcgcttcattcctgaagtggctgtagctta ccc aagtcaaagcccttgacgacccagatcaagataaagaagcctcccaaggtcactatgaagacaggcaagagcctgctgc acctccacagcaccctggagatgttcgcagctcggtggcggagcaaggctccaatgtccctctttctcctagaagtgca cttcaatctgaaggtccagtactcagtgcatgagaaccagctgcagatggccacttctttggacagattactgagctt gtcccggaagtcctcatcgattggcaacttcaatgagagggaattaactggcttcatcaccagctatctcgaagaagcc tacatcccagttgtcaatgatgtgcttcaagtggggctcccactcccggactttctggccatgaattacaacctggctg agctggacatagtagagcttgggggcatcatggaacctgccgacatatga (Seq ID No: 36)
42B: Polypeptide Sequences
MLRILCLALCSLLTGTRADPGALLRLGMDIMNREVQSAMDESHILEKMAAEAGKKQPGMKPIKGITNLKVK DVQLPVITLNFVPGVGIFQCVSTGMTVTGKSFMGGNMEIIVALNITATNRLLRDEETGLPVFKSEGCEVILV NVKTNLPSNMLPKMVNKFLDSTLHKVLPGLMCPAIDAVLVYVNRKWTNLSDPMPVGQMGTVKYVLMSAP ATTASYIQLDFSPWQQQKGKTIKLADAGEALTFPEGYAKGSSQLLLPATFLSAELALLQKSFHVNIQDTMI
GELPPQTTKTLARFIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFL LEVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPWNDVLQVGLPLP DFLAMNYNLAELDIVELGGIMEPADI (SEQ ID NO: 35)
Table 43: BPIL 325-4 nucleic acid and polypeptide sequences
43A: Nucleic Acid Sequences atgctgcggatcctgtgcctggcactctgcagcctgctgactggcacgcgagctgaccctggggcactgctgcggttgg gcatggacatcatgaaccaggtccagagcgccatggatgagagtcatatcctggagaagatggcagccgaggcaggcaa gaaacagccagggatgaaacctatcaagggcatcaccaatttgaaggtgaaggatgtccagctgcccgtcatcacactg aactttgtacctggagtgggcatcttccaatgtgtgtccacaggcatgaccgtcactggcaagagcttcatgggaggga acatggagatcatcgtggccctgaacatcacagccaccaaccggcttctgcgggatgaggagacaggcctccccgtgtt caagagtgagggctgtgaggtcatcctggtcaatgtgaagactaacctgcctagcaacatgctccccaagatggtcaac aagttcctggacagcaccctgcacaaagtcctccctgggctgatgtgtcccgccatcgatgcagtcctggtgtatgtga acaggaagtggaccaacctcagtgaccccatgcctgtgggccagatgggcaccgtcaaatatgttctgatgtccgcacc agccaccacagccagctacatccaactggacttcagtcctgtggtgcagcagcaaaagggcaaaaccatcaagcttgct gatgccggggaggccctcacgttccctgagggttatgccaaaggctcgtcgcagctgctgctcccagccaccttcctct ctgcagagcttgcccttctgcagaagtcctttcatgtgaatatccaggatacaatgattggtgagctgcccccacaaac caccaagaccctggctcgc tcattcctgaagtggctgtagcttatcccaagtcaaagcccttgacgacccagatcaag ataaagaagcctcccaaggtcactatgaagacaggcaagagcctgctgcacctccacagcaccctggagatgttcgcag ctcggtggcggagcaaggctccaatgtccctctttctcctagaagtgcacttcaatctgaaggtccagtactcagtgca cgagaaccagctgcagatggccacttctttggacagattactgagcttgtcccggaagtcctcatcgattggcaacttc aatgagagggaattaactggcttcatcaccagctatctcgaagaagcctacatcccagttgtcaatgatgtgcttcaag tggggctcccactcccggactttctggccatgaattacaatctggctgagctggacatagtagagaatgccctgatgct ggacttgaagctgggctga (SEQ ID NO: 44)
43B: Polypeptide Sequences
MLRILCLALCSLLTGTRADPGALLRLGMDIMNQVQSAMDESHILEKMAAEAGKKQPGMKPIKGITNLKVKDVQLPVITL NFVPGVGIFQCVSTGMTVTGKSFMGGNMEIIVALNITATNRLLRDEETGLPVFKSEGCEVILVNVKTNLPSNMLPKMVN KFLDSTLHKVLPGLMCPAIDAVLVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPWQQQKGKTIKLA DAGEALTFPEGYAKGSSQLLLPATFLSAELALLQKSFHVNIQDTMIGELPPQTTKTLARFIPEVAVAYPKSKPLTTQIK IKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFLLEVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNF NERELTGFITSYLEEAYIPWNDVLQVGLPLPDFLAMNYNLAELDIVENALMLDLKLG fSEQ ID NO: 45)
The BPIL-325 encoded polypeptides have homology (approximately 50% similarity) to human BPI precursor (GenBank Ace. No. AAA51841). A search of the NCBI CD-Search database demonstrated that BPIL 325-2, 355-3 and 325-4 have significant similarity to multiple bactericidal/permeability-increasing protein superfamily domains, as shown in Table 44.
This degree of homology between a BPIL-253-2, 325-3 and 325-5 polypeptide and bactericidal/permeability-increasing protein superfamily domains (both in terms of length and complexity) is very unlikely to have occurred by chance alone as represented by the Expect (E) value in Table 44. Table 44
44A: NCBI CD-Search results for BPIL 325-2
Score E
Sequences producing significant alignments: (bits) value gn1|Smart|BPI2 BPI/LBP/CETP C-terminal domain; Bactericidal permeability-incr.. 50.0 9e-08 gnl|Pfam|pfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 34.4 0.004
44B: NCBI CD-Search results for BPIL 325-3
Score E
Sequences producing significant alignments: (bits) value gnl|Smart|BPI2 BPI/LBP/CETP C-terminal domain; Bactericidal permeability-incr.. 73.4 2e-14 gnllSmartlBPIl BPI/LBP/CETP N-terminal domain; Bactericidal permeability-incr.. 61.3 le-10 gnl|Pfam|pfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 46.1 4e-06
44C: NCBI CD-Search results for BPIL 325-4
Score E
Sequences producing significant alignments: (bits) value gnllSmartlBPI2 BPI/LBP/CETP C-terminal domain; Bactericidal permeability-incr.. 74.9 7e-15 gnllSmartlBPIl BPI/LBP/CETP N-terminal domain; Bactericidal permeability-incr.. 54.3 le-08 gnllPfam|pfam01273 LBP_BPI_CETP, LBP / BPI / CETP family 47.6 le-06
CD multiple alignments of the bactericidal/permeability-increasing protein superfamily domains are presented in Table 45. Black outlined amino acids indicates identity, whereas grey outlined amino acids indicates conservative substitution. Based on its relatedness, the BPIL-325-2, 325-3 and 325-4 proteins are novel members of the bactericidal/permeability-increasing protein superfamily.
Table 45:
45A. Alignment of BPIL 325 2, 325- 3 and 325-4 with the BPI/LBP/CETP C-terminal domain
Figure imgf000067_0001
Figure imgf000068_0001
325_3 AMNY LAELDI VE (Seq ID No 150)
325_4 AMNYNLAELDIVENALML- (Seq ID No 151) gi|2554693|pdb|lBPl| (Seq ID No 152) gi j 115110 BACTERICIDAL PERMEAB (Seq ID No 153) gij 2497615 BACTERICIDAL PERMEA (Seq ID No 154) gij 112184 probable ligand-bind (Seq ID No 155)
Consensus (Seq ID No 156)
45B. Alignment of BPIL 325-2, 325-3 and 325-4 with the BPI/LBP/CETP family domain
10 20 50 60
325 2
325 3
Figure imgf000068_0002
onsensus
70 80 90 120
|....|....|....|. |....|....|....|.
325 2
Figure imgf000068_0003
onsensus
130 140 160 180
|....| |....|....|....|....|....|....|....|
325 2
Figure imgf000068_0004
Consensus
190 200 210 220 230 240
..|.. ..|.. ..|.. ••I 325 2
Figure imgf000069_0001
Consensus
250 260 270 280 290 300
|....|....|....| ..|.. ..|.. ••I
325 2
Figure imgf000069_0002
onsensus
310 320 330 340 350 360 ..|.. |....|....|....|. ..|....|
325 2
Figure imgf000069_0003
onsensus
Figure imgf000069_0005
Figure imgf000069_0004
gi I 2822120 BACTERICIDAL PERMEA (Seq ID No : 162 ) gi j 115110 BACTERICIDAL PERMEAB (Seq ID No : 163) Consensus
Figure imgf000070_0001
(Seq ID No : 164 )
45C. Alignment of BPIL 325- 3and 325-4 with the BPI/LBP/CETP N-terminal domain
10 30 50 60
I
325 3
Figure imgf000070_0002
Consensus
BPIL-325-2, 325-3 and 325-4 polypeptides were modeled using the crystal structure of human BPI (Beamer et al. Science 276, 1997) using GeneAtlas software. The model demonstrated tertiary structure similar to BPI. Specifically, the BPIL-325 protein structure has the characteristic boomerang-shape with two domains of other members of the bactericidal/permeability-increasing protein superfamily. Structural overlays of the molecular model of BPIL-325 against BPI using the program Profile-3D were performed. Profile 3-D is a threading program which measures the compatibility of the protein model with its sequence using a 3-D profile. Using defined parameters Profile 3-D computes a verify score for the model. A verify score between 0 and 1 correlates to a good model. A verify score under 0 correlates to a bad model.
The following verify scores were obtained for each of the BPIL-325 polypeptides:
Figure imgf000071_0001
The above described models confirm that the BPIL-325 polypeptides retain tertiary structural homology with the BPI superfamily.
In addition, primary sequence structural alignments were also performed for 325-4. Table
46 illustrates the primary sequence alignment with secondary structures of BPI. As illustrated in
Table 46 BPIL325-4 polypeptide has the conserved cysteine residues that are involved in disulfide bond formation between the final strand of the beta sheet and the long alpha helix. Consistent with the conserved tertiary structure, Table 46 also illustrates that much of the amino acids in regions of secondary structure are conserved between BPIL-325 and BPI.
Table 46: Primary Sequence Alignment of BPIL 325-4 with Secondary Structure of BPI
Sbjct 1 VNPGWVRISQKG DYASQQGTAALQKELK IKIPDYSDSFKIKH GKGHYSFYSMDIRE 60
+PG ++R+ G+D +Q +A + + + + K + K ++ +++ Query 18 ADPGALLRL GMDIMNQVQSA DESHI EKMAAE - - -AGKKQPGMKPIKGITN KVKD 71 > >
Sbjct 61 FQ PSSQISMVP VG KFSISNA IKISGKWKAQKRFLKMSGNFDLSIEGMSISAD KLG 120
QLP ++ VP VG+ +S M GN ++ + +I+A +I_ Query 72 VQLPVIT NFVPGVGIFQCVSTGMTVT GKSFMGGNMEIIVAL-NITATNRLL 122 s s
-> > HHHHHHHHHH-HHHHHHHHHHHHHHHHH
Sbjct: 121 SNPTSGKPTITCSSCSSHINSλmVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTN 180
: + +G P C + +V ++ ++ +K ++S L + +C + + Query: 123 RDEETGLPVFKSEGCEVILVNVKTNLPS NMLPKMVNKF DSTLHKVLPG MCPAI-D 178
HHHHH HHHHH --> > >
Sbjct: 181 SVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHH PP-PF 239
: +V + + + + + Y L4-+ PATTA + + + Query: 179 AVLVYWRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQ DFSPWQQQKGKTIKLAD 238 >HHHHHHHHHHHHH > HHHHH
Sbjct: 240 APPVMEFPAAHDR VYLGLSDYFFNTAG VYQEAGVLKMTLRDDMIPKESKFRLTTKFFG 299 : A + FP + + F +A + + ++D MI + TTK Query: 239 AGEALTFPEGYAKGSSQLLLPATFLSAELALLQKS-FHVNIQDTMIGEL--PPQTTKTLA 295
HHH HHHH > >
Sbjct: 300 TFLPEVA KFPNMK-IQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALA-SLFL 357 : F+PEVA +P K + + PP ++++ + ++ FA S SLFL Query: 296 RFIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSL HLHSTLEMFAAR RSKAPMS FL 355 > HHHHHHHHHHHHHHH-HHH
Sbjct: 358 IGMHTTGS EVSAESNR VGELKLDR L-LE KHSNIGPFPVE LQDIMNYIVPILVLPR 416 : + +H ++ S N+L LDRL L K S+IG F L + + +P Query: 356 LEVHFNL VQYSVHENQ QMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPV 415
HHHHHHH-> >
Sbjct: 417 V EKLQKGFP PTPARVQLYNWLQPHQNFL FGAD 452 (Seq ID No: 172)
: VN+ Q G PLP + L +N L+ Query: 416 WDVLQVGLPLPDFLAMNYNLAELDIVENALMLDLK 451 (Seq ID No: 173)
KEY: H = denotes alpha helix secondary structure > = denotes beta-strand secondary structure (variable amounts of hyphens .
H-H = one residue breaks in an alpha helix structure
S S = disulfide bond
NOTE : Residues 17 -45 , 82 - 108 , and 142 - 169 of BPI (public) are considered critical for LPS -binding, LPS-neutralization, and bactericidal activity, according to Beamer et al . (Science VOL. _76 20 JUNE 1997 pi86i).
Primary sequence alignments within 4 A of the carboxy and amino terminal binding pocket were also performed and are illustrated in Tables 47-48. Amino acids that are underlined in Table 47-48 represent amino acids are comprise the binding pocket. By "binding pocket" is meant to be the site where a BPILX ligand interacts ( e.g. charge interaction, hydrophobic forces, van der Waals attraction, hydrogen bonding, dipole interactionn and entropy increases) with a BPILX polypeptide. In Tables 47 and 48 below, the BPILX sequence of the present invention is the Query and the BPI known sequence is the subject.
Table 47: BPIL 325-4 N-terminal binding pocket
Sbj ct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIRE 60
+PG ++R+ G+D +Q +A + + + + K + K ++ +++ Query 18 ADPGALLRL G DIMNQVQSAMDESHILEK AAE AGKKQPGMKPIKGITNLKVKD 71
Sbj Ct : 61 FQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLG 120 : QLP ++ VP VG+ +S M GN ++ + +I+A +L Query: 72 VQLPVITLNFVPGVGIFQCVSTGMTVT GKSFMGGNMEIIVAL-NITATNRLL 122
Sbjct 121 SNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTN 180
+ +G P C + +V ++ L ++ +K ++S L + +C + + Query 123 RDEETGLPVFKSEGCEVILVNVKTNLPS NMLPKMVNKFLDSTLHKVLPGLMCPAI-D 178
Sbjct: 181 SVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPP-PF 239
: +V + + L + + + Y L++ PATTA + + +
Query: 179 AVLVYVNRKWTNLSDPMPVGOMGTVKYVLMSAPATTASYIOLDFSPWOOQKGKTIKLAD 238
Sbjct: 240 APPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFG 299
: A + FP + + L F +A + + ++D MI + TTK
Query: 239 AGEALTFPEGYAKGSSQLLLPATFLSAELALLQKS-FHVNIQDTMIGEL--PPQTTKTLA 295 Sbjct: 300 TFLPEVAKKFPNMK-IQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALA-SLFL 357
: F+PEVA +P K + + PP ++++ + 4-+ FA S SLFL
Query: 296 RFIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFL 355
Sbjct 358 IGMHTTGSMEVSAESNRLVGELKLDRLL-LELKHSNIGPFPVELLQDIMNYIVPILVLPR 416
+ +H ++ S N+L LDRLL L K S+IG F L + + +P Query 356 LEVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPV 415
Sbjct: 417 VNEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGAD 452 (Seq ID No: 174) : VN+ LQ G PLP + L +N L+
Query: 416 VNDVLQVGLPLPDFLAMNYNLAELDIVENALMLDLK 451 (Seq ID No: 175)
Table 48: BPIL 325-4 C-terminal binding pocket
Sbjct 1 VNPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIRE 60
+PG +4-R+ G+D +Q +A + + + + K + K ++ +-.+ Query 18 ADPGALLRL GMDIMNQVQSAMDESHILEKMAAE AGKKQPGMKPIKGITNLKVKD 71
Sbjct 61 FQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLG 120
QLP ++ VP VG+ +S M GN ++ + +I+A +L
Query 72 VQLPVITLNFVPGVGIFQCVSTGMTVT GKSFMGGNMEIIVAL-NITATNRLL 122
Sbjct 121 SNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTN 180
+ +G P C + +V ++ L ++ +K ++S L + +C + + Query 123 RDEETGLPVFKSEGCEVILVNVKTNLPS NMLPKMVNKFLDSTLHKVLPGLMCPAI-D 178
Sbjct: 181 SVSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPP-PF 239
: +V + + L + + + Y L++ PATTA + + + Query: 179 AVLVYVNRK TNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPWQQQKGKTIKLAD 238
Sbjct: 240 APPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFG 299
: A + FP + + L F +A + + ++D MI + TTK Query: 239 AGEALTFPEGYAKGSSQLLLPATFLSAELALLQKS-FHVNIQDTMIGEL--PPQTTKTLA 295 Sbjct: 300 TFLPEVAKKFPNMK-IQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALA-SLFL 357 : F+PEVA +P K + + PP ++++ + ++ FA S SLFL Query: 296 RFIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFL 355
Sbjct: 358 IGMHTTGSMEVSAESNRLVGELKLDRLL-LELKHSNIGPFPVELLQDIMNYIVPILVLPR 416 : + +H +4- S N+L LDRLL L K S+IG F L + + +P Query: 356 LEVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPV 415
Sbjct 417 VNEKLQKGFPLPTPARVQLYNWLQPHQNFLLFGAD 452 (Seq ID No : 176 )
VN+ LQ G PLP 4- L +N L+ Query 416 VNDVLQVGLPLPDFLAMNYNLAELDIVENALMLDLK 451 (Seq ID No : 177 )
Table 60: Primary Sequence Alignment of BPIL 325-3 with Secondary Structure of BPI >HHHHHHHHHHHHHHHHHHHHH >
Sbjct: 2 NPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREF 61
+PG ++R+ G+D +++ +A+ + K+ ++ K + K ++ +++ Query: 19 DPGALLRL GMDIMNREVQSAMDESHILEKMAA- -EAGKKQPGMKPIKGITNLKVKDV 73
Sbjct: 62 QLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGS 121
QLP 4-4- VP VG+ 4-S G K F+ GN 4-+ 4- +I+A 4-L Query: 74 QLPVITLNFVPGVGIFQCVST GMTVTGKSFMG--GNMEIIVAL-NITATNRLLR 124
> > HHHHHHHHHH-HHHHHHHHHHHHHHHHHHH
Sbjct: 122 NPTSGKPTITCSSCSSHINSVHVHISKSKVG LIQLFHKKIESALRNKMNSQVCEKVTNS 181
4- 4-G P C 4- 4-V 4-4- L 4-4- 4-K 4-4-S L 4- +C + ++
Query: 125 DEETGLPVFKSEGCEVILVNVKTNLPS NMLPKMVNKFLDSTLHKVLPGLMCPAI-DA 180
HHH HHHHH --> > >
Sbjct: 182 VSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPP-PFA 240
V 4- 4- L 4- 4- 4- Y L++ PATTA 4- 4- 4- A
Query: 181 VLVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPWQQQKGKTIKLADA 240 >HHHHHHHHHHHHH > HHHHHH
Sbjct: 241 PPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGT 300
+ FP + + L F 4-A L 4- 4- 4-4-D MI 4- TTK Query: 241 GEALTFPEGYAKGSSQLLLPATFLSAELALLQKS-FHVNIQDTMIGEL--PPQTTKTLAR 297
HH HHHH > >
Sbjct: 301 FLPEVAKKFPNMK-IQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALA-SLFLI 358
F4-PEVA 4-P K 4- 4- PP 4-4-4-4- 4- 4-4- FA S SLFL+
Query: 298 FIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAAR RSKAPMSLFLL 357 > HHHHHHHHHHHHHHH-HHHH
Sbjct: 359 GMHTTGSMEVSAEΞNRLVGELKLDRLL-LELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417
4-H 4-4- S N4-L LDRLL L K S+IG F L + + +P V Query: 358 EVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPW 417
HHHHHH-> > >
Sbjct: 418 NEKLQKGFPLPTPARVQLYNWLQ-PHQNFLLFGADV 453 (seq id no: 207)
N+ LQ G PLP + L ++ AD+ Query: 418 NDVLQVGLPLPDFLAMNYNLAELDIVELGGIMEPADI 454 (seq id no: 208)
KEY: H = denotes alpha helix secondary structure > = denotes beta-strand secondary structure (variable amounts of hyphens . H-H = one residue breaks in an alpha helix structure disulfide bond
Table 61: BPIL 325-3 N-terminal binding pocket Sbjct: 2 NPGVyVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREF 61 +PG ++R+ G+D +++ +A+ + K+ ++ K + K ++ +++ Query: 19 DPGALLRL GMDIMNREVQSAMDESHILEKMAA- -EAGKKQPGMKPIKGITNLKVKDV 73
Sbjct: 62 QLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGS 121 QLP ++ VP VG+ +S G K F+ GN ++ + +I+A +L
Query: 74 QLPVITLNFVPGVGIFQCVST GMTVTGKSFMG- -GNMEIIVAL-NITATNRLLR 124
Sbjct: 122 NPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNS 181 + +G P C + +V ++ L ++ +K ++S L + +C + ++ Query: 125 DEETGLPVFKSEGCEVILVNVKTNLPS NMLPKMVNKFLDSTLHKVLPGLMCPAI-DA 180
Sbjct: 182 VSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPP-PFA 240
V + + L + + + Y L++ PATTA + + + A
Query: 181 VLVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPWOOOKGKTIKLADA 240
Sbjct: 241 PPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGT 300
+ FP + + L F +A L + + ++D MI + TTK Query: 241 GEALTFPEGYAKGSSQLLLPATFLSAELALLQKS-FHVNIQDTMIGEL--PPQTTKTLAR 297 Sbjct: 301 FLPEVAKKFPNMK-IQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALA-SLFLI 358 F+PEVA +P K + + PP ++++ + ++ FA S SLFL+ Query: 298 FIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAAR RSKAPMSLFLL 357
Sbjct: 359 GMHTTGSMEVSAESNRLVGELKLDRLL-LELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417 +H ++ S N+L LDRLL L K S+IG F L + + +P V
Query: 358 EVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPW 417
Sbjct: 418 NEKLQKGFPLPTPARVQLYNWLQ-PHQNFLLFGADV 453 (SEQ ID NO: 209) N+ LQ G PLP + L ++ AD+ Query: 418 NDVLQVGLPLPDFLAMNYNLAELDIVELGGIMEPADI 454 (SEQ ID NO : 210)
Table 62: BPIL 325-3 C-terminal binding pocket
Sbjct: 2 NPGVWRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREF 61 +PG ++R+ G+D +++ +A+ + K+ ++ K + K ++ +++
Query: 19 DPGALLRL GMDIMNREVQSAMDESHILEKMAA- -EAGKKQPGMKPIKGITNLKVKDV 73
Sbjct: 62 QLPSSQISMVPNVGLKFSISNANIKISGK KAQKRFLKMSGNFDLSIEGMSISADLKLGS 121 QLP ++ VP VG+ +S G K F+ GN ++ + +I+A +L Query: 74 QLPVITLNFVPGVGIFQCVST GMTVTGKSFMG--GNMEIIVAL-NITATNRLLR 124
Sbjct: 122 NPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEIVTNS 181
+ +G P C + +V ++ L ++ +K ++S L + +C + ++ Query: 125 DEETGLPVFKSEGCEVILVNVKTNLPS NMLPKMVNKFLDSTLHKVLPGLMCPAI-DA 180
Sbj ct : 182 VSSKLQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPP- PFA 240
V + + L + + + Y L++ PATTA + + + A
Query : 181 VLVYWRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPVVQQQKGKTIKLADA 240 Sbj ct : 241 PPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGT 300
+ FP + + L F + L + + ++D MI + TTK
Query : 241 GEALTFPEGYAKGSSQLLLPATFLSAELALLQKS^FHVNIQDTMIGEL- -PPQTTKTLAR 297
Sbjct: 301 FLPEVAKKFPNMK-IQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSALA-SLFLI 358
F+PEVA +P K + + PP ++++ + ++ FA S SLFL+ Query: 298 FIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFLL 357 Sbjct: 359 GMHTTGSMEVSAESNRLVGELKLDRLL-LELKHSNIGPFPVELLQDIMNYIVPILVLPRV 417 +H ++ S N+L LDRLL L K S+IG F L + + +P V Query: 358 EVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPVV 417
Sbjct: 418 NEKLQKGFPLPTPARVQLYNWLQ-PHQNFLLFGADV 453 (SEQ ID NO: 211) N+ LQ G PLP + L ++ AD+
Query: 418 NDVLQVGLPLPDFLAMNYNLAELDIVELGGIMEPADI 454 (SEQ ID NO: 212)
DEFINITIONS The term "nucleotide sequence" refers to a heteropolymer of nucleotides or the sequence of these nucleotides. The terms "nucleic acid" and "polynucleotide" are also used interchangeably herein to refer to a heteropolymer of nucleotides. Generally, nucleic acid segments provided by this invention may be assembled from fragments of the genome and short oligonucleotide linkers, or from a series of oligonucleotides, or from individual nucleotides, to provide a synthetic nucleic acid which is capable of being expressed in a recombinant transcriptional unit comprising regulatory elements derived from a microbial or viral operon, or a eukaryotic gene. In alternate embodiments, a nucleotide sequence, polynucleotide or nucleic acid can correspond to a genomic sequence (e.g., can contain intron as well as exon sequence) or cDNA sequences (that is, contains no intron sequence). The terms "oligonucleotide fragment" or a "polynucleotide fragment", "portion," or
"segment" is a stretch of polypeptide nucleotide residues which is long enough to use in polymerase chain reaction (PCR) or various hybridization procedures to identify or amplify identical or related parts of mRNA or DNA molecules.
The terms "oligonucleotides" or "nucleic acid probes" are prepared based on the polynucleotide sequences provided in the present invention. Oligonucleotides comprise portions of such a polynucleotide sequence having at least about 15 nucleotides and usually at least about 20 nucleotides. Nucleic acid probes comprise portions of such a polynucleotide sequence having fewer nucleotides than about 6 kb, usually fewer than about 1 kb. After appropriate testing to eliminate false positives, these probes may, for example, be used to determine whether specific mRNA molecules are present in a cell or tissue or to isolate similar nucleic acid sequences from chromosomal DNA as described by Walsh et al. (Walsh, P.S. et al., 1992, PCR Methods Appl 1:241-250).
The term "probes" includes naturally occurring or recombinant or chemically synthesized single- or double-stranded nucleic acids. They may be labeled by nick translation, Klenow fill-in reaction, PCR or other methods well known in the art. Probes of the present invention, their preparation and/or labeling are elaborated in Sambrook, J. et al., 1989, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY; or Ausubel, F.M. et al., 1989, Current Protocols in Molecular Biology, John Wiley & Sons, New York NY, both of which are incorporated herein by reference in their entirety.
The "oligonucleotide fragment," "polynucleotide fragment," "portion," "segment,", "oligonucleotide" or "nucleic acid probe" is at least about 15, and preferably at least about 50, 100, 200, 300, 400, 500, 600, 700 or 800 nucleotides in length.
The term "stringent" is used to refer to conditions that are commonly understood in the art as stringent. Stringent conditions can include highly stringent conditions (i.e., hybridization to filter-bound DNA under in 0.5 M NaHP04, 7% sodium dodecyl sulfate (SDS), 1 mM EDTA at 65° C, and washing in O.lxSSC/0.1% SDS at 68 C), and moderately stringent conditions (i.e., washing in 0.2xSSC/0.1% SDS at 42° C).
In instances wherein hybridization of deoxyoligonucleotides is concerned, additional exemplary highly stringent hybridization conditions include washing in 6xSSC/0.05% sodium pyrophosphate at 37°C (for 14-base oligos), 48°C (for 17-base oligos), 55°C (for 20-base oligos), and 60°C (for 23-base oligos).
The term "recombinant," when used herein to refer to a polypeptide or protein, means that a polypeptide or protein is derived from recombinant (e.g., microbial or mammalian) expression systems. "Microbial" refers to recombinant polypeptides or proteins made in bacterial or fungal (e.g., yeast) expression systems. As a product, "recombinant microbial" defines a polypeptide or protein essentially free of native endogenous substances and unaccompanied by associated native glycosylation. Polypeptides or proteins expressed in most bacterial cultures, e.g., E, coli, will be free of glycosylation modifications; polypeptides or proteins expressed in yeast will have a glycosylation pattern in general different from those expressed in mammalian cells. The term "recombinant expression vehicle or vector" refers to a plasmid or phage or virus or vector, for expressing a polypeptide from a DNA (RNA) sequence. An expression vehicle can comprise a transcriptional unit comprising an assembly of (1) a genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers, (2) a structural or coding sequence which is transcribed into mRNA and translated into protein, and (3) appropriate transcription initiation and termination sequences. Structural units intended for use in yeast or eukaryotic expression systems preferably include a leader sequence enabling extracellular secretion of translated protein by a host cell. Alternatively, where recombinant protein is expressed without a leader or transport sequence, it may include an N-terminal methionine residue. This residue may or may not be subsequently cleaved from the expressed recombinant protein to provide a final product.
The term "recombinant expression system" means host cells which have stably integrated a recombinant transcriptional unit into chromosomal DNA or carry the recombinant transcriptional unit extrachromosomally. Recombinant expression systems as defined herein will express heterologous polypeptides or proteins upon induction of the regulatory elements linked to the DNA segment or synthetic gene to be expressed. This term also means host cells which have stably integrated a recombinant genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers. Recombinant expression systems as defined herein will express polypeptides or proteins endogenous to the cell upon induction of the regulatory elements linked to the endogenous DNA segment or gene to be expressed. The cells can be prokaryotic or eukaryotic.
The term "open reading frame," ORF, means a series of nucleotide triplets coding for amino acids without any termination codons and is a sequence translatable into protein. The term "expression modulating fragment," EMF, means a series of nucleotides which modulates the expression of an operably linked ORF or another EMF.
As used herein, a sequence is said to "modulate the expression of an operably linked sequence" when the expression of the sequence is altered by the presence of the EMF. EMFs include, but are not limited to, promoters, and promoter modulating sequences (inducible elements). One class of EMFs are fragments which induce the expression or an operably linked ORF in response to a specific regulatory factor or physiological event. As used herein, an "uptake modulating fragment," UMF, means a series of nucleotides which mediate the uptake of a linked DNA fragment into a cell. UMFs can be readily identified using known UMFs as a target sequence or target motif with the computer-based systems described below. The presence and activity of a UMF can be confirmed by attaching the suspected UMF to a marker sequence. The resulting nucleic acid molecule is then incubated with an appropriate host under appropriate conditions and the uptake of the marker sequence is determined. As described above, a UMF will increase the frequency of uptake of a linked marker sequence. The term "active" refers to those forms of the polypeptide which retain the biological and/or immunological activities of any naturally occurring polypeptide.
The term "biologically active" refers to the biological activity of a naturally occurring polypeptide as well as to the ability of the polypeptide to exhibit an immunological activity. A polypeptide exhibits an "immunological activity" when antibodies can be generated that are directed against the polypeptide. The term "naturally occurring polypeptide" refers to polypeptides produced by cells that have not been genetically engineered and specifically contemplates various polypeptides arising from post-translational modifications of the polypeptide including, but not limited to, acetylation, carboxylation, glycosylation, phosphorylation, lipidation and acylation.
The term "mature" refers to a polypeptide that has been post-translationally modified or that corresponds in primary amino acid sequence to a polypeptide that has been post-translationally modified. A mature polypeptide includes, but is not limited to, a polypeptide which comprises a primary amino acid sequence that has been processed from a "pre-," "pro-," or "pre-pro" amino acid sequence; a polypeptide which comprises a primary amino acid sequence corresponding to that of a polypeptide that has been processed from a "pre-," "pro-," or "pre-pro" amino acid sequence; a polypeptide that has been post-translationally modified via such modifications as, for example, acetylation, carboxylation, glycosylation, phosphorylation, lipidation and acylation.
The term "derivative" refers to polypeptides chemically modified by such techniques as ubiquitination, labeling (e.g., with radionucleotides or various enzymes), pegylation (derivatization with polyethylene glycol) and insertion or substitution by chemical synthesis of amino acids such as ornithine, which do not normally occur in human proteins. The term "recombinant variant" refers to any polypeptide differing from naturally occurring polypeptides by amino acid insertions, deletions, and substitutions, created using recombinant DNA techniques. Guidance in determining which amino acid residues may be replaced, added or deleted without abolishing activities of interest, such as cellular trafficking, may be found by comparing the sequence of the particular polypeptide with that of homologous peptides and minimizing the number of amino acid sequence changes made in regions of high homology. Preferably, amino acid "substitutions" are the result of replacing one amino acid with another amino acid having similar structural and/or chemical properties, i.e., conservative amino acid replacements. Amino acid substitutions may be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues involved. For example, nonpolar (hydrophobic) amino acids include alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan, and methionine; polar neutral amino acids include glycine, serine, threonine, cysteine, tyrosine, asparagine, and glutamine; positively charged (basic) amino acids include arginine, lysine, and histidine; and negatively charged (acidic) amino acids include aspartic acid and glutamic acid. "Insertions" or "deletions" are typically in the range of about 1 to 5 amino acids. The variation allowed may be experimentally determined by systematically making insertions, deletions, or substitutions of amino acids in a polypeptide molecule using recombinant DNA techniques and assaying the resulting recombinant variants for activity. Alternatively, where alteration of function is desired, insertions, deletions or non- conservative alterations can be engineered to produce altered polypeptides. Such alterations can, for example, alter one or more of the biological functions or biochemical characteristics of the polypeptides of the invention. For example, such alterations may change polypeptide characteristics such as ligand-binding affinities, interchain affinities, or degradation/turnover rate. Further, such alterations can be selected so as to generate polypeptides that are better suited for expression, scale up and the like in the host cells chosen for expression. For example, cysteine residues can be deleted or substituted with another amino acid residue in order to eliminate disulfide bridges.
As used herein, "substantially equivalent" may refer both to nucleotide and amino acid sequences, for example a mutant sequence, that varies from a reference sequence by one or more substitutions, deletions, or additions, the net effect of which does not result in an adverse functional dissimilarity between the reference and subject sequences. In an embodiment, such a substantially equivalent sequence varies from one of those listed herein i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.25 or less. Such a sequence is said to have 75% sequence identity to the listed sequence. Such a substantially equivalent sequence may be routinely identified by applying the foregoing algorithm.
In one embodiment, a substantially equivalent, e.g., mutant, sequence of the invention varies from a listed sequence by no more than 20%, i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.2 or less. Such a sequence is said to have 80% sequence identity to the listed sequence. Such a substantially equivalent sequence can be routinely identified by applying the foregoing algorithm. In another embodiment, a substantially equivalent, e.g., mutant, sequence of the invention varies from a listed sequence by no more than 10%, i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.1 or less. Such a sequence is said to have 90% sequence identity to the listed sequence. Such a substantially equivalent sequence can be routinely identified by applying the foregoing algorithm.
In an alternate embodiment a substantially equivalent sequence of the invention varies from a listed sequence by no more than 5%, i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.05 or less. Such a sequence is said to have 95% sequence identity to the listed sequence. Such a substantially equivalent sequence can be routinely identified by applying the foregoing algorithm.
In yet another alternate embodiment, a substantially equivalent sequence of the invention varies from a listed sequences by no more than 2%, i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.02 or less. Such a sequence is said to have 98% sequence identity to the listed sequence. Such a substantially equivalent sequence can be routinely identified by applying the foregoing algorithm. Substantially equivalent, one example of a substantial equivalent is an amino acid mutant, amino acid sequences according to the invention generally have at least 95% sequence identity with a listed amino acid sequence, whereas substantially equivalent nucleotide sequence of the invention can have lower percent sequence identities, taking into account, for example, the redundancy or degeneracy of the genetic code. For the purposes of the present invention, sequences having substantially equivalent biological activity and substantially equivalent expression characteristics are considered substantially equivalent. In a preferred embodiment, for the purposes of determining equivalence, truncation of the mature sequence (e.g., via a mutation which creates a spurious stop codon) are disregarded.
Nucleic acid sequences encoding such substantially equivalent sequences, e.g., sequences of the recited percent identities, can also routinely be isolated and identified via standard hybridization procedures well known to those of skill in the art.
Where desired, an expression vector may be designed to contain a "signal or leader sequence" which will direct the polypeptide through the membrane of a cell. Such a sequence may be naturally present on the polypeptides of the present invention or provided from heterologous protein sources by recombinant DNA techniques.
A polypeptide "fragment," "portion," or "segment" is a stretch of amino acid residues of at least about 5 amino acids, often at least about 7 amino acids or about at least about 9 to 13 amino acids, and, in various embodiments, at least about 17, 25, 50, 75, 100, 150, 200, 300, 400 or more amino acids. To be "active," any polypeptide must have sufficient length to display biologic and/or immunologic activity.
Recombinant variants encoding these same or similar polypeptides may be synthesized or selected by making use of the "redundancy" in the genetic code. Various codon substitutions, such as the silent changes which produce various restriction sites, may be introduced to optimize cloning into a plasmid or viral vector or expression in a particular prokaryotic or eukaryotic system. Mutations in the polynucleotide sequence may be reflected in the polypeptide or domains of other peptides added to the polypeptide to modify the properties of any part of the polypeptide, to change characteristics such as ligand-binding affinities, interchain affinities, or degradation/turnover rate. Such variant nucleic acids and polypeptides are to be considered part of the present invention. The term "activated" cells as used herein refers to those cells that are engaged in extracellular or intracellular membrane trafficking, including the export of neurosecretory or enzymatic molecules as part of a normal or disease process.
The term "purified" as used herein denotes that the indicated nucleic acid or polypeptide is present in the substantial absence of other biological macromolecules, e.g., polynucleotides, proteins, and the like. In one embodiment, the polynucleotide or polypeptide is purified such that it constitutes at least 95% by weight, more preferably at least 99.8% by weight, of the indicated biological macromolecules present (but water, buffers, and other small molecules, especially molecules having a molecular weight of less than 1000 daltons, can be present).
The term "isolated" as used herein refers to a nucleic acid or polypeptide separated from at least one other component (e.g., nucleic acid or polypeptide) present with the nucleic acid or polypeptide in its natural source. In one embodiment, the nucleic acid or polypeptide is found in the presence of (if anything) only a solvent, buffer, ion, or other component normally present in a solution of the same. The terms "isolated" and "purified" do not encompass nucleic acids or polypeptides present in their natural source.
The term "infection" refers to the introduction of nucleic acids into a suitable host cell by use of a virus or viral vector.
The term "transformation" means introducing DNA into a suitable host cell so that the DNA is replicable, either as an extrachromosomal element, or by chromosomal integration. The term "transfection" refers to the taking up of an expression vector by a suitable host cell, whether or not any coding sequences are in fact expressed. The term "intermediate fragment" means a nucleic acid between about 5 and about 1000 bases in length. In various embodiments, such nucleic acids are between about 10 and about 40 bp in length, or at least about 100, 200, 300, 400, 500, 600, 700, 800 or 900 bp in length. The term "secreted" protein refers to a protein that is transported across or through a membrane, including transport as a result of signal sequences in its amino acid sequence when it is expressed in a suitable host cell. "Secreted" proteins include without limitation proteins secreted wholly (e.g., soluble proteins) or partially (e.g., receptors, including seven-transmembrane receptors) from the cell in which they are expressed. "Secreted" proteins also include without limitation proteins which are transported across the membrane of the endoplasmic reticulum.
Each of the above terms is meant to encompasses all that is described for each, unless the context dictates otherwise.
POLYNUCLEOTIDES AND NUCLEIC ACIDS OF THE INVENTION
Nucleotide and amino acid sequences of the invention are reported below. Fragments of the proteins of the present invention which are capable of exhibiting biological activity are also encompassed by the present invention. Fragments of the protein may be in linear form or they may be cyclized using known methods, for example, as described in H. U. Saragovi, et al., Bio/Technology 10, 773-778 (1992) and in R. S. McDowell, et al., J. Amer. Chem. Soc. 114, 9245- 9253 (1992), both of which are incoφorated herein by reference. Such fragments may be fused to carrier molecules such as immunoglobulins for many purposes, including increasing the valency of protein binding sites. For example, fragments of the protein may be fused through "linker" sequences to the Fc portion of an immunoglobulin. For a bivalent form of the protein, such a fusion could be to the Fc portion of an IgG molecule. Other immunoglobulin isotypes may also be used to generate such fusions. For example, a protein-IgM fusion would generate a decavalent form of the protein of the invention. The present invention also provides both full-length and mature forms of the disclosed proteins. The full-length forms of the polypeptides of the invention are identified in the figures and the sequence listing by translation of the nucleotide sequence of each nucleic acid molecule. Mature forms of the polypeptides of the invention can routinely be obtained by expression of the disclosed nucleotides encoding the full-length polypeptides in a suitable mammalian cell or other host cell. The sequence of the mature forms of the polypeptides can also routinely be determined from the amino acid sequence of the full-length polypeptides.
The present invention also provides genes corresponding to cDNA sequences disclosed herein. The corresponding genes can be isolated in accordance with known methods using the sequence information disclosed herein. Such methods include the preparation of probes or primers from the disclosed sequence information for identification and/or amplification of genes in appropriate genomic libraries or other sources of genomic materials. Where the protein of the present invention is membrane-bound (e.g., is a receptor), the present invention also provides for soluble forms of such protein. In such forms part or all of the intracellular and transmembrane domains of the protein are deleted such that the protein is fully secreted from the cell in which it is expressed. The intracellular and transmembrane domains of proteins of the invention can be identified in accordance with known techniques for determination of such domains from sequence information.
Species homologs of the disclosed polynucleotides and proteins are also provided by the present invention. Species homologs may be isolated and identified by making suitable probes or primers from the sequences provided herein and screening a suitable nucleic acid source from the desired species. Species homologs can include, but are not limited to human, murine, rat or Drosophila species homologs.
The invention also encompasses allelic variants of the disclosed polynucleotides or proteins; that is, naturally-occurring alternative forms of the isolated polynucleotide which also encode proteins which are identical, homologous or related to that encoded by the polynucleotides. Sequences and allelic variant sequences of the invention can include, but are not limited to human, murine, rat and Drosophila sequences.
The compositions of the present invention include isolated polynucleotides, including recombinant DNA molecules, cloned genes or degenerate variants thereof, especially naturally occurring variants such as allelic variants, novel isolated polypeptides, and antibodies that specifically recognize one or more epitopes present on such polypeptides.
NUCLEIC ACIDS OF THE INVENTION
One aspect of the present invention pertains to isolated nucleic acid molecules that encode BPIL polypeptides or biologically-active portions thereof. The polynucleotides of the invention include the complement of any of the BPIL polynucleotides. The polynucleotides of the invention also provide polynucleotides that are substantially equivalent to the BPIL polynucleotides. The polynucleotides of this invention also include those polynucleotides that hybridize to SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, 44 under stringent and moderately stringent hybridization conditions. The polynucleotides of the present invention also include those polynucleotides that are 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99% homologous to polynucleotides of SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, 44. A BPIL nucleic acid can encode a mature BPIL polypeptide. As used herein, a "mature" form of a polypeptide or protein disclosed in the present invention is the product of a naturally occurring polypeptide or precursor form or proprotein. The naturally occurring polypeptide, precursor or proprotein includes, by way of nonlimiting example, the full length gene product, encoded by the corresponding gene. Alternatively, it can be defined as the polypeptide, precursor or proprotein encoded by an open reading frame described herein. The product "mature" form arises, again by way of nonlimiting example, as a result of one or more naturally occurring processing steps as they may take place within the cell, or host cell, in which the gene product arises. Examples of such processing steps leading to a "mature" form of a polypeptide or protein include the cleavage of the N-terminal methionine residue encoded by the initiation codon of an open reading frame, or the proteolytic cleavage of a signal peptide or leader sequence. Thus a mature form arising from a precursor polypeptide or protein that has residues 1 to N, where residue 1 is the N-terminal methionine, would have residues 2 through N remaining after removal of the N- terminal methionine. Alternatively, a mature form arising from a precursor polypeptide or protein having residues 1 to N, in which an N-terminal signal sequence from residue 1 to residue M is cleaved, would have the residues from residue M+l to residue N remaining. Further as used herein, a "mature" form of a polypeptide or protein may arise from a step of post-translational modification other than a proteolytic cleavage event. Such additional processes include, by way of non-limiting example, glycosylation, myristoylation or phosphorylation. In general, a mature polypeptide or protein may result from the operation of only one of these processes, or a combination of any of them.
A polynucleotide according to the invention can be joined to any of a variety of other nucleotide sequences by well-established recombinant DNA techniques (see Sambrook, J., et al. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY). Useful nucleotide sequences for joining to polypeptides include an assortment of vectors, e.g., plasmids, cosmids, lambda phage derivatives, phagemids, and the like, that are well known in the art. Accordingly, the invention also provides a vector including a polynucleotide of the invention and a host cell containing the polynucleotide. In general, the vector contains an origin of replication functional in at least one organism, convenient restriction endonuclease sites, and a selectable marker for the host cell. Vectors according to the invention include expression vectors, replication vectors, probe generation vectors, and sequencing vectors. A host cell according to the invention can be a prokaryotic or eukaryotic cell and can be a unicellular organism or part of a multicellular organism.
The sequences falling within the scope of the present invention are not limited to the specific sequences herein described, but also include allelic variations thereof. Allelic variations can be routinely determined by comparing the sequence provided in SEQ ID NOS:l, 3, 5, 7, 9, 11- 15, 26, 28, 33, 36, 38, 40, and 44, a representative intermediate fragment thereof or a nucleotide sequence at least 99.9% identical to SEQ ID NOS:l, 3, 5, 7, 9, 11-15, 26, 28, 33, 36, 38, 40 or 44 with a sequence from another isolate of the same species. Furthermore, to accommodate codon variability, the invention includes nucleic acid molecules coding for the same amino acid sequences as do the specific ORFs disclosed herein. In other words, in the coding region of an ORF, substitution of one codon for another which encodes the same amino acid is expressly contemplated.
The present invention further provides recombinant constructs comprising a nucleic acid having the sequence of SEQ ID NOS:l, 3, 5, 7, 9, 11-15, 26, 28, 33, 36, 38, 40 and 44, or an intermediate fragment thereof, or another of the nucleic acid molecules of the invention. The recombinant constructs of the present invention comprise a vector, such as a plasmid or viral vector, into which a nucleic acid having the sequence of SEQ ID NOS:l, 3, 5, 7, 9, 11-15, 26, 28, 33, 36, 38, 40, or 44 or an intermediate fragment thereof, or another of the nucleic acid molecules of the invention, is inserted, in a forward or reverse orientation. In the case of a vector comprising one of the ORFs of the present invention, the vector may further comprise regulatory sequences, including for example, a promoter, operably linked to the ORF. For vectors comprising the EMFs and UMFs of the present invention, the vector may further comprise a marker sequence or heterologous ORF operably linked to the EMF or UMF. Large numbers of suitable vectors and promoters are known to those of skill in the art and are commercially available for generating the recombinant constructs of the present invention. The following vectors are provided by way of example. Bacterial: pBs, phagescript, PsiX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene); pTrc99A, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia). Eukaryotic: pWLneo, pSV2cat, pOG44, PXTI, pSG (Stratagene) pSVK3, pBPV, pMSG, pSVL (Pharmacia). The isolated polynucleotides of the invention may be operably linked to an expression control sequence such as the pMT2 or pED expression vectors disclosed in Kaufman et al., Nucleic Acids Res. 19, 4485-4490 (1991), in order to produce the protein recombinantly. Many suitable expression control sequences are known in the art. General methods of expressing recombinant proteins are also known and are exemplified in R. Kaufman, Methods in Enzymology 185, 537-566 (1990). As defined herein "operably linked" means that the isolated polynucleotide of the invention and an expression control sequence are situated within a vector or cell in such a way that the protein is expressed by a host cell which has been transformed (transfected) with the ligated polynucleotide/ expression control sequence. Promoter regions can be selected from any desired gene using CAT (chloramphenicol transferase) vectors or other vectors with selectable markers. Two appropriate vectors are pKK232-8 and pCM7. Particular named bacterial promoters include lad, lacZ, T3, T7, gpt, lambda PR, and trc. Eukaryotic promoters include CMV immediate early, HSV thymidine kinase, early and late SV40, LTRs from retrovirus, and mouse metallothionein-I. Selection of the appropriate vector and promoter is well within the level of ordinary skill in the art. Generally, recombinant expression vectors will include origins of replication and selectable markers permitting transformation of the host cell, e.g., the ampicillin resistance gene of E. coli and S. cerevisiae TRP1 gene, and a promoter derived from a highly-expressed gene to direct transcription of a downstream structural sequence. Such promoters can be derived from operons encoding glycolytic enzymes such as 3-phosphoglycerate kinase (PGK), a-factor, acid phosphatase, or heat shock proteins, among others. The heterologous structural sequence is assembled in appropriate phase with translation initiation and termination sequences, and preferably, a leader sequence capable of directing secretion of translated protein into the periplasmic space or extracellular medium. Optionally, the heterologous sequence can encode a fusion protein including an N- terminal identification peptide imparting desired characteristics, e.g., stabilization or simplified purification of expressed recombinant product. Useful expression vectors for bacterial use are constructed by inserting a structural DNA sequence encoding a desired protein together with suitable translation initiation and termination signals in operable reading phase with a functional promoter. The vector will comprise one or more phenotypic selectable markers and an origin of replication to ensure maintenance of the vector and to, if desirable, provide amplification within the host. Suitable prokaryotic hosts for transformation include E. coli, Bacillus subtilis, Salmonella typhimurium and various species within the genera Pseudomonas, Streptomyces, and Staphylococcus, although others may also be employed as a matter of choice.
As a representative but non-limiting example, useful expression vectors for bacterial use can comprise a selectable marker and bacterial origin of replication derived from commercially available plasmids comprising genetic elements of the well known cloning vector pBR322 (ATCC 37017). Such commercial vectors include, for example, pKK223-3 (Pharmacia Fine Chemicals, Uppsala, Sweden) and GEM 1 (Promega Biotec, Madison, Wl, USA). These pBR322 "backbone" sections are combined with an appropriate promoter and the structural sequence to be expressed. Following transformation of a suitable host strain and growth of the host strain to an appropriate cell density, the selected promoter is induced or derepressed by appropriate means (e.g., temperature shift or chemical induction) and cells are cultured for an additional period. Cells are typically harvested by centrifugation, disrupted by physical or chemical means, and the resulting crude extract retained for further purification.
The nucleic acid sequences of the invention are further directed to sequences which encode variants of the described nucleic acids. These amino acid sequence variants may be prepared by methods known in the art by introducing appropriate nucleotide changes into a native or variant polynucleotide. There are two variables in the construction of amino acid sequence variants: the location of the mutation and the nature of the mutation. The amino acid sequence variants of the nucleic acids are preferably constructed by mutating the polynucleotide to give an amino acid sequence that does not occur in nature. These amino acid alterations can be made at sites that differ in the nucleic acids from different species (variable positions) or in highly conserved regions (constant regions). Sites at such locations will typically be modified in series, e.g., by substituting first with conservative choices (e.g., hydrophobic amino acid to a different hydrophobic amino acid) and then with more distant choices (e.g., hydrophobic amino acid to a charged amino acid), and then deletions or insertions may be made at the target site. Amino acid sequence deletions generally range from about 1 to 30 residues, preferably about 1 to 10 residues, and are typically contiguous. Amino acid insertions include amino- and/or carboxyl-terminal fusions ranging in length from one to one hundred or more residues, as well as intrasequence insertions of single or multiple amino acid residues. Intrasequence insertions may range generally from about 1 to 10 amino residues, preferably from 1 to 5 residues. Examples of terminal insertions include the heterologous signal sequences necessary for secretion or for intracellular targeting in different host cells.
In a preferred method, polynucleotides encoding the novel nucleic acids are changed via site-directed mutagenesis. This method uses oligonucleotide sequences that encode the polynucleotide sequence of the desired amino acid variant, as well as a sufficient adjacent nucleotide on both sides of the changed amino acid to form a stable duplex on either side of the site of being changed. In general, the techniques of site-directed mutagenesis are well known to those of skill in the art and this technique is exemplified by publications such as, Edelman et al., DNA 2: 183 (1983). A versatile and efficient method for producing site-specific changes in a polynucleotide sequence was published by Zoller and Smith, Nucleic Acids Res. 10:6487-6500 (1982). PCR may also be used to create amino acid sequence variants of the novel nucleic acids. When small amounts of template DNA are used as starting material, primer(s) that differs slightly in sequence from the corresponding region in the template DNA can generate the desired amino acid variant! PCR amplification results in a population of product DNA fragments that differ from the polynucleotide template encoding the polypeptide at the position specified by the primer. The product DNA fragments replace the corresponding region in the plasmid and this gives the desired amino acid variant.
A further technique for generating amino acid variants is the cassette mutagenesis technique described in Wells et al., Gene 34:315 (1985); and other mutagenesis techniques well known in the art, such as, for example, the techniques in Sambrook et al., supra, and Current Protocols in
Molecular Biology, Ausubel et al. Due to the inherent degeneracy of the genetic code, other DNA sequences which encode substantially the same or a functionally equivalent amino acid sequence may be used in the practice of the invention for the cloning and expression of these novel nucleic acids. Such DNA sequences include those which are capable of hybridizing to the appropriate novel nucleic acid sequence under stringent conditions.
Finally, it is to be understood that the nucleic acid molecules of the invention further include any nucleic acid molecule that encodes the polypeptides of the invention, as described herein.
ANTISENSE NUCLEIC ACIDS Another aspect of the invention pertains to isolated antisense nucleic acid molecules that can hybridize to, or are complementary to, the nucleic acid molecule comprising the BPILX nucleotide sequence, or fragments, analogs or derivatives thereof. An "antisense" nucleic acid comprises a nucleotide sequence that is complementary to a "sense" nucleic acid encoding a protein (e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence). In specific aspects, antisense nucleic acid molecules are provided that comprise a sequence complementary to at least about 10, 25, 50, 100, 250 or 500 nucleotides or an entire BPILX coding strand, or to only a portion thereof. Nucleic acid molecules encoding fragments, homologs, derivatives and analogs of a BPILX or antisense nucleic acids complementary to a BPILX nucleic acid sequence of are additionally provided.
In one embodiment, an antisense nucleic acid molecule is antisense to a "coding region" of the coding strand of a nucleotide sequence encoding a BPILX protein. The term "coding region" refers to the region of the nucleotide sequence comprising codons which are translated into amino acid residues. In another embodiment, the antisense nucleic acid molecule is antisense to a "conceding region" of the coding strand of a nucleotide sequence encoding the BPILX protein. The term "conceding region" refers to 5' and 3' sequences which flank the coding region that are not translated into amino acids (i.e., also referred to as 5' and 3' untranslated regions).
Given the coding strand sequences encoding the BPILX protein disclosed herein, antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick or Hoogsteen base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of BPILX mRNA, but more preferably is an oligonucleotide that is antisense to only a portion of the coding or noncoding region of BPILX mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of BPILX mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis or enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally-occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids (e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used). Examples of modified nucleotides that can be used to generate the antisense nucleic acid include: 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4- acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5- carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6- isopentenyladenine, 1 -methylguanine, 1 -methyhnosine, 2,2-dimethylguanine, 2-methyladenine, 2- methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5- methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5'- methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5- oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2- thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6- diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following section).
The antisense nucleic acid molecules of the invention are typically administered to a subject or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a BPILX protein to thereby inhibit expression of the protein (e.g., by inhibiting transcription and/or translation). The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule that binds to DNA duplexes, through specific interactions in the major groove of the double helix. An example of a route of administration of antisense nucleic acid molecules of the invention includes direct injection at a tissue site. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then administered systemically. For example, for systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface (e.g., by linking the antisense nucleic acid molecules to peptides or antibodies that bind to cell surface receptors or antigens). The antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. To achieve sufficient nucleic acid molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong pol II or pol III promoter are preferred. In yet another embodiment, the antisense nucleic acid molecule of the invention is an alpha- anomeric nucleic acid molecule. An alpha-anomeric nucleic acid molecule forms specific double- stranded hybrids with complementary RNA in which, contrary to the usual alpha-units, the strands run parallel to each other. See, e.g., Gaultier, et al., 1987. Nucl. Acids Res. 15: 6625-6641. The antisense nucleic acid molecule can also comprise a 2'-o-methylribonucleotide (see, e.g., Inoue, et al. 1987. Nucl. Acids Res. 15: 6131-6148) or a chimeric RNA-DNA analogue (see, e.g., Inoue, et al., 1987. FEBS Lett. 215: 327-330.
RlBOZYMES AND PNA MOIETIES Nucleic acid modifications include, by way of non-limiting example, modified bases, and nucleic acids whose sugar phosphate backbones are modified or derivatized. These modifications are carried out at least in part to enhance the chemical stability of the modified nucleic acid, such that they can be used, for example, as antisense binding nucleic acids in therapeutic applications in a subject. In one embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity that are capable of cleaving a single- stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes as described in Haselhoff and Gerlach 1988. Nature 334: 585-591) can be used to catalytically cleave BPILX mRNA transcripts to thereby inhibit translation of BPILX mRNA. A ribozyme having specificity for a BPILX-encoding nucleic acid can be designed based upon the nucleotide sequence of a BPILX cDNA disclosed herein. For example, a derivative of a Tetrahymena L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a BPILX-encoding mRNA. See, e.g., U.S. Patent 4,987,071 to Cech, et al. and U.S. Patent 5,116,742 to Cech, et al. BPILX mRNA can also be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel et al., (1993) Science 261 :1411-1418.
Alternatively, BPILX gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of the BPILX nucleic acid (e.g., the BPILX promoter and/or enhancers) to form triple helical structures that prevent transcription of the BPILX gene in target cells. See, e.g., Helene, 1991. Anticancer Drug Des. 6: 569-84; Helene, et al. 1992. Ann. N.Y. Acad. Sci. 660: 27-36; Maher, 1992. Bioassays 14: 807-15. In various embodiments, the BPILX nucleic acids can be modified at the base moiety, sugar moiety or phosphate backbone to improve, e.g., the stability, hybridization, or solubility of the molecule. For example, the deoxyribose phosphate backbone of the nucleic acids can be modified to generate peptide nucleic acids. See, e.g., Hyrup, et al., 1996. Bioorg Med Chem 4: 5-23. As used herein, the terms "peptide nucleic acids" or "PNAs" refer to nucleic acid mimics (e.g., DNA mimics) in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only the four natural nucleobases are retained. The neutral backbone of PNAs has been shown to allow for specific hybridization to DNA and RNA under conditions of low ionic strength. The synthesis of PNA oligomers can be performed using standard solid phase peptide synthesis protocols as described in Hyrup, et al., 1996. supra; Perry-O'Keefe, et al., 1996. Proc. Natl. Acad. Sci. USA 93: 14670-14675.
PNAs of BPILX can be used in therapeutic and diagnostic applications. For example, PNAs can be used as antisense or antigene agents for sequence-specific modulation of gene expression by, e.g., inducing transcription or translation arrest or inhibiting replication. PNAs of BPILX can also be used, for example, in the analysis of single base pair mutations in a gene (e.g., PNA directed PCR clamping; as artificial restriction enzymes when used in combination with other enzymes, e.g., SI nucleases (see, Hyrup, et al., 1996.supra); or as probes or primers for DNA sequence and hybridization (see, Hyrup, et al., 1996, supra; Perry-O'Keefe, et al., 1996. supra).
In another embodiment, PNAs of BPILX can be modified, e.g., to enhance their stability or cellular uptake, by attaching lipophilic or other helper groups to PNA, by the formation of PNA- DNA chimeras, or by the use of liposomes or other techniques of drug delivery known in the art. For example, PNA-DNA chimeras of BPILX can be generated that may combine the advantageous properties of PNA and DNA. Such chimeras allow DNA recognition enzymes (e.g., RNase H and DNA polymerases) to interact with the DNA portion while the PNA portion would provide high binding affinity and specificity. PNA-DNA chimeras can be linked using linkers of appropriate lengths selected in terms of base stacking, number of bonds between the nucleobases, and orientation (see, Hyrup, etal., 1996. supra). The synthesis of PNA-DNA chimeras can be performed as described in Hyrup, et al., 1996. supra and Finn, et al., 1996. Nucl Acids Res 24: 3357-3363. For example, a DNA chain can be synthesized on a solid support using standard phosphoramidite coupling chemistry, and modified nucleoside analogs, e.g., 5'-(4- methoxytrityl)amino-5'-deoxy-thymidine phosphoramidite, can be used between the PNA and the 5' end of DNA. See, e.g., Mag, et al., 1989. Nucl Acid Res 17: 5973-5988. PNA monomers are then coupled in a stepwise manner to produce a chimeric molecule with a 5' PNA segment and a 3' DNA segment. See, e.g., Finn, et al., 1996. supra. Alternatively, chimeric molecules can be synthesized with a 5' DNA segment and a 3' PNA segment. See, e.g., Petersen, et al., 1975. Bioorg. Med. Chem. Lett. 5 : 1119- 11124.
In other embodiments, the oligonucleotide may include other appended groups such as peptides (e.g., for targeting host cell receptors in vivo), or agents facilitating transport across the cell membrane (see, e.g., Letsinger, et al., 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 6553-6556; Lemaitre, et al., 1987. Proc. Natl. Acad. Sci. 84: 648-652; PCT Publication No. WO88/09810) or the blood-brain barrier (see, e.g., PCT Publication No. WO 89/10134). In addition, oligonucleotides can be modified with hybridization triggered cleavage agents (see, e.g., Krol, et al., 1988. BioTechniques 6:958-976) or intercalating agents (see, e.g., Zon, 1988. Pharm. Res. 5: 539-549). To this end, the oligonucleotide can be conjugated to another molecule, e.g., a peptide, a hybridization triggered cross-linking agent, a transport agent, a hybridization-triggered cleavage agent, and the like.
HOSTS
The present invention further provides host cells genetically engineered to contain the polynucleotides of the invention. For example, such host cells may contain nucleic acids of the invention introduced into the host cell using known transformation, transfection or infection methods. The present invention still further provides host cells genetically engineered to express the polynucleotides of the invention, wherein such polynucleotides are in operative association with a regulatory sequence heterologous to the host cell which drives expression of the polynucleotides in the cell. The host cell can be a higher eukaryotic host cell, such as a mammalian cell, a lower eukaryotic host cell, such as a yeast cell, or the host cell can be a prokaryotic cell, such as a bacterial cell. Introduction of the recombinant construct into the host cell can be effected by calcium phosphate transfection, DEAE, dextran mediated transfection, or electroporation (Davis, L. et al., Basic Methods in Molecular Biology (1986)). The host cells containing one of polynucleotides of the invention, can be used in conventional manners to produce the gene product encoded by the isolated fragment (in the case of an ORF) or can be used to produce a heterologous protein under the control of the EMF.
Any host/vector system can be used to express one or more of the ORFs of the present invention. These include, but are not limited to, eukaryotic hosts such as HeLa cells, Cv-1 cell, COS cells, and Sf9 cells, as well as prokaryotic host such as E. coli and B. subtilis. The most preferred cells are those which do not normally express the particular polypeptide or protein or which expresses the polypeptide or protein at low natural level. Mature proteins can be expressed in mammalian cells, yeast, bacteria, or other cells under the control of appropriate promoters. Cell- free translation systems can also be employed to produce such proteins using RNAs derived from the DNA constructs of the present invention. Appropriate cloning and expression vectors for use with prokaryotic and eukaryotic hosts are described by Sambrook, et al., in Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor, New York (1989), the disclosure of which is hereby incorporated by reference.
Various mammalian cell culture systems can also be employed to express recombinant protein. Examples of mammalian expression systems include the COS-7 lines of monkey kidney fibroblasts, described by Gluzman, Cell 23:175 (1981), and other cell lines capable of expressing a compatible vector, for example, the C127, 3T3, CHO, HeLa and BHK cell tines. Mammalian expression vectors will comprise an origin of replication, a suitable promoter and also any necessary ribosome binding sites, polyadenylation site, splice donor and acceptor sites, transcriptional termination sequences, and 5' flanking nontranscribed sequences. DNA sequences derived from the SV40 viral genome, for example, SV40 origin, early promoter, enhancer, splice, and polyadenylation sites may be used to provide the required nontranscribed genetic elements. Recombinant polypeptides and proteins produced in bacterial culture are usually isolated by initial extraction from cell pellets, followed by one or more salting-out, aqueous ion exchange or size exclusion chromatography steps. Protein refolding steps can be used, as necessary, in completing configuration of the mature protein. Finally, high performance liquid chromatography (HPLC) can be employed for final purification steps. Microbial cells employed in expression of proteins can be disrupted by any convenient method, including freeze-thaw cycling, sonication, mechanical disruption, or use of cell lysing agents. A number of types of cells may act as suitable host cells for expression of the protein.
Mammalian host cells include, for example, monkey COS cells, Chinese Hamster Ovary (CHO) cells, human kidney 293 cells, human epidermal A431 cells, human Colo205 cells, 3T3 cells, CV-1 cells, other transformed primate cell lines, normal diploid cells, cell strains derived from in vitro culture of primary tissue, primary explants, HeLa cells, mouse L cells, BHK, HL-60, U937, HaK or Jurkat cells. Alternatively, it may be possible to produce the protein in lower eukaryotes such as yeast or in prokaryotes such as bacteria. Potentially suitable yeast strains include Saccharomyces cerevisiae, Schizosaccharomyces pombe, Kluyveromyces strains, Candida, or any yeast strain capable of expressing heterologous proteins. Potentially suitable bacterial strains include Escherichia coli, Bacillus subtilis, Salmonella typhimurium, or any bacterial strain capable of expressing heterologous proteins. If the protein is made in yeast or bacteria, it may be necessary to modify the protein produced therein, for example by phosphorylation or glycosylation of the appropriate sites, in order to obtain the functional protein. Such covalent attachments may be accomplished using known chemical or enzymatic methods.
In another embodiment of the present invention, cells and tissues may be engineered to express an endogenous gene comprising the polynucleotides of the invention under the control of inducible regulatory elements, in which case the regulatory sequences of the endogenous gene may be replaced by homologous recombination. As described herein, gene targeting can be used to replace a gene's existing regulatory region with a regulatory sequence isolated from a different gene or a novel regulatory sequence synthesized by genetic engineering methods. Such regulatory sequences may be comprised of promoters, enhancers, scaffold-attachment regions, negative regulatory elements, transcriptional initiation sites, regulatory protein binding sites or combinations of said sequences. Alternatively, sequences which affect the structure or stability of the RNA or protein produced may be replaced, removed, added, or otherwise modified by targeting, including polyadenylation signals, mRNA stability elements, splice sites, leader sequences for enhancing or modifying transport or secretion properties of the protein, or other sequences which alter or improve the function or stability of protein or RNA molecules.
The targeting event may be a simple insertion of the regulatory sequence, placing the gene under the control of the new regulatory sequence, e.g., inserting a new promoter or enhancer or both upstream of a gene. Alternatively, the targeting event may be a simple deletion of a regulatory element, such as the deletion of a tissue-specific negative regulatory element. Alternatively, the targeting event may replace an existing element; for example, a tissue-specific enhancer can be replaced by an enhancer that has broader or different cell-type specificity than the naturally occurring elements. Here, the naturally occurring sequences are deleted and new sequences are added. In all cases, the identification of the targeting event may be facilitated by the use of one or more selectable marker genes that are contiguous with the targeting DNA, allowing for the selection of cells in which the exogenous DNA has integrated into the host cell genome. The identification of the targeting event may also be facilitated by the use of one or more marker genes exhibiting the property of negative selection, such that the negatively selectable marker is linked to the exogenous DNA, but configured such that the negatively selectable marker flanks the targeting sequence, and such that a correct homologous recombination event with sequences in the host cell genome does not result in the stable integration of the negatively selectable marker. Markers useful for this purpose include the Herpes Simplex Virus thymidine kinase (TK) gene or the bacterial xanthine-guanine phosphoribosyl-transferase (gpt) gene.
The gene targeting or gene activation techniques which can be used in accordance with this aspect of the invention are more particularly described in U.S. Patent No. 5,272,071 to Chappel; U.S. Patent No. 5,578,461 to Sherwin et al.; International Application No. PCT/US92/09627 (WO93/09222) by Selden et al.; and International Application No. PCT/US90/06436 (WO91/06667) by Skoultchi et al., each of which is incorporated by reference herein in its entirety.
POLYPEPTIDES OF THE INVENTION The isolated polypeptides of the invention include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO:2; or a polypeptide comprising amino acid residues 1-26, 27-458, 23-54, or 55-458 of SEQ ID NO:2.
The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO:4; or a polypeptide comprising amino acid residues 1-26, 27-458, 23-54, or 55-458 of SEQ ID NO:4.
The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO:6; or a polypeptide comprising amino acid residues 1-23, 24-476, 24-209, 210-253, 254-273, 274-310 or 311-476 of SEQ ID
NO:6. The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO:8; or a polypeptide comprising amino acid residues 1-23, 24-476, 24-209, 210-253, 254-273, 274-310 or 311-476 of SEQ ID NO:8.
The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO:27, or a polypeptide comprising amino acid residues 1-23, 24-507, 24-209, 210-253, 254-273, 274-310 or 311-507 of SEQ ID NO:27.
The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO:29, or a polypeptide comprising amino acid residues 1-23, 24-455, 24-158, 159-202, 203-222, 223-259 or 260-455 of SEQ ID NO:29.
The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO:39, or a polypeptide comprising amino acid residues 1-23, 24-507, 24-209, 210-253, 254-273, 274-310 or 311-507 of SEQ ID NO:39. The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO:41, or a polypeptide comprising amino acid residues 1-23, 24-455, 24-158, 159-202, 203-222, 223-259 or 260-455 of SEQ ID NO:41.
The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO:32, or a polypeptide comprising amino acid residues 1-48 or 49-150 of SEQ ID NO:32.
The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequences of SEQ ID NO:35, or a polypeptide comprising amino acid residues 1-235, 236-454, 236-284, 285-381 or 381-454 of SEQ ID NO:35. The isolated polypeptides of the invention still further include, but are not limited to, a polypeptide comprising the amino acid sequence of SEQ ID NO: 10 and SEQ ID NO:45, and fragments thereof.
The isolated polypeptides of the invention further include polypeptides that are substantially equivalent to the polypeptides of SEQ ID NOS:2, 4, 6, 8, 10, 27, 29, 32, 39, 41, 45 or 45, or to specific domains thereof. Preferred embodiments include those in which the protein produced by such process is a mature form of the protein.
Protein compositions of the present invention may further comprise an acceptable carrier, such as a hydrophilic, e.g., pharmaceutically acceptable, carrier. The invention also relates to methods for producing a polypeptide comprising growing a culture of the cells of the invention in a suitable culture medium, and purifying the protein from the culture. For example, the methods of the invention include a process for producing a polypeptide in which a host cell containing a suitable expression vector that includes a polynucleotide of the invention is cultured under conditions that allow expression of the encoded polypeptide. The polypeptide can be recovered from the culture, conveniently from the culture medium, and further purified.
The present invention further provides isolated polypeptides encoded by the nucleic acid fragments of the present invention or by degenerate variants of the nucleic acid fragments of the present invention. By "degenerate variant" is intended nucleotide fragments which differ from a nucleic acid fragment of the present invention (e.g., an ORF) by nucleotide sequence but, due to the degeneracy of the genetic code, encode an identical polypeptide sequence. Preferred nucleic acid fragments of the present invention are the ORFs that encode proteins.
A variety of methodologies known in the art can be utilized to obtain any one of the isolated polypeptides or proteins of the present invention. At the simplest level, the amino acid sequence can be synthesized using commercially available peptide synthesizers. This is particularly useful in producing small peptides and fragments of larger polypeptides. Fragments are useful, for example, in generating antibodies against the native polypeptide. In an alternative method, the polypeptide or protein is purified from bacterial cells which naturally produce the polypeptide or protein. One skilled in the art can readily follow known methods for isolating polypeptides and proteins in order to obtain one of the isolated polypeptides or proteins of the present invention. These include, but are not limited to, immunochromatography, HPLC, size-exclusion chromatography, ion-exchange chromatography, and immuno-affinity chromatography. See, e.g., Scopes, Protein Purification: Principles and Practice, Springer-Verlag (1994); Sambrook, et al., in Molecular Cloning: A Laboratory Manual; Ausubel et al., Current Protocols in Molecular Biology. The polypeptides and proteins of the present invention can alternatively be purified from cells which have been altered to express the desired polypeptide or protein. As used herein, a cell is said to be altered to express a desired polypeptide or protein when the cell, through genetic manipulation, is made to produce a polypeptide or protein which it normally does not produce or which the cell normally produces at a lower level. One skilled in the art can readily adapt procedures for introducing and expressing either recombinant or synthetic sequences into eukaryotic or prokaryotic cells in order to generate a cell which produces one of the polypeptides or proteins of the present invention. The purified polypeptides can be used in in vitro binding assays which are well known in the art to identify molecules which bind to the polypeptides. These molecules include but are not limited to, for e.g., small molecules, molecules from combinatorial libraries, antibodies or other proteins. The molecules identified in the binding assay are then tested for antagonist or agonist activity in in vivo tissue culture or animal models that are well known in the art. In brief, the molecules are titrated into a plurality of cell cultures or animals and then tested for either cell/animal death or prolonged survival of the animal/cells.
In addition, the binding molecules may be complexed with toxins, e.g., ricin or cholera, or with other compounds that are toxic to cells. The toxin-binding molecule complex is then targeted to the tumor or other cell by the specificity of the binding molecule for SEQ ID NOS:2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41 or 45, or another of the polypeptide of the invention.
The protein of the invention may also be expressed as a product of transgenic animals, e.g., as a component of the milk of transgenic cows, goats, pigs, or sheep which are characterized by somatic or germ cells containing a nucleotide sequence encoding the protein. The protein may also be produced by known conventional chemical synthesis. Methods for constructing the proteins of the present invention by synthetic means are known to those skilled in the art. The synthetically-constructed protein sequences, by virtue of sharing primary, secondary or tertiary structural and/or conformational characteristics with proteins may possess biological properties in common therewith, including protein activity. Thus, they may be employed as biologically active or immunological substitutes for natural, purified proteins in screening of therapeutic compounds and in immunological processes for the development of antibodies.
The proteins provided herein also include proteins characterized by amino acid sequences similar to those of purified proteins but into which modification are naturally provided or deliberately engineered. For example, modifications in the peptide or DNA sequences can be made by those skilled in the art using known techniques. Modifications of interest in the protein sequences may include the alteration, substitution, replacement, insertion or deletion of a selected amino acid residue in the coding sequence. For example, one or more of the cysteine residues may be deleted or replaced with another amino acid to alter the conformation of the molecule. Techniques for such alteration, substitution, replacement, insertion or deletion are well known to those skilled in the art (see, e.g., U.S. Pat. No. 4,518,584). Preferably, such alteration, substitution, replacement, insertion or deletion retains the desired activity of the protein.
Other fragments and derivatives of the sequences of proteins which would be expected to retain protein activity in whole or in part and may thus be useful for screening or other immunological methodologies may also be easily made by those skilled in the art given the disclosures herein. Such modifications are believed to be encompassed by the present invention. The protein may also be produced by operably linking the isolated polynucleotide of the invention to suitable control sequences in one or more insect expression vectors, and employing an insect expression system. Materials and methods for baculovirus/insect cell expression systems are commercially available in kit form from, e.g., Invitrogen, San Diego, Calif., U.S.A. (the MaxBat.RTM. kit), and such methods are well known in the art, as described in Summers and Smith, Texas Agricultural Experiment Station Bulletin No. 1555 (1987), incoφorated herein by reference. As used herein, an insect cell capable of expressing a polynucleotide of the present invention is "transformed."
The protein of the invention may be prepared by culturing transformed host cells under culture conditions suitable to express the recombinant protein. The resulting expressed protein may then be purified from such culture (i.e., from culture medium or cell extracts) using known purification processes, such as gel filtration and ion exchange chromatography. The purification of the protein may also include an affinity column containing agents which will bind to the protein; one or more column steps over such affinity resins as concanavalin A-agarose, heparin- toyopearl.RTM. or Cibacrom blue 3GA Sepharose.RTM.; one or more steps involving hydrophobic interaction chromatography using such resins as phenyl ether, butyl ether, or propyl ether; or immunoaffϊnity chromatography.
Alternatively, the protein of the invention may also be expressed in a form which will facilitate purification. For example, it may be expressed as a fusion protein, such as those of maltose binding protein (MBP), glutathione-S-transferase (GST) or thioredoxin (TRX). Kits for expression and purification of such fusion proteins are commercially available from New England BioLab (Beverly, Mass.), Pharmacia (Piscataway, NJ.) and In Vitrogen, respectively. The protein can also be tagged with an epitope and subsequently purified by using a specific antibody directed to such epitope. One such epitope ("Flag") is commercially available from Kodak (New Haven, Conn.).
Finally, one or more reverse-phase high performance liquid chromatography (RP-HPLC) steps employing hydrophobic RP-HPLC media, e.g., silica gel having pendant methyl or other aliphatic groups, can be employed to further purify the protein. Some or all of the foregoing purification steps, in various combinations, can also be employed to provide a substantially homogeneous isolated recombinant protein. The protein thus purified is substantially free of other mammalian proteins and is defined in accordance with the present invention as an "isolated protein."
CHIMERIC AND FUSION PROTEINS
The invention also provides BPILX chimeric or fusion proteins. As used herein, a BPILX "chimeric protein" or "fusion protein" comprises a BPILX polypeptide operatively-linked to a non- BPILX polypeptide. A "BPILX polypeptide" refers to a polypeptide having an amino acid sequence corresponding to a BPILX protein, whereas a "non-BPILX polypeptide" refers to a polypeptide having an amino acid sequence corresponding to a protein that is not substantially homologous to the BPILX protein, e.g., a protein that is different from the BPILX protein and that is derived from the same or a different organism. Within a BPILX fusion protein the BPILX polypeptide can correspond to all or a portion of a BPILX protein. In one embodiment, a BPILX fusion protein comprises at least one biologically-active portion of a BPILX protein. In another embodiment, a BPILX fusion protein comprises at least two biologically-active portions of a BPILX protein. In yet another embodiment, a BPILX fusion protein comprises at least three biologically-active portions of a BPILX protein. Within the fusion protein, the term "operatively- linked" is intended to indicate that the BPILX polypeptide and the non-BPILX polypeptide are fused in- frame with one another. The non-BPILX polypeptide can be fused to the N-terminus or C-terminus of the BPILX polypeptide.
In one embodiment, the fusion protein is a GST-BPILX fusion protein in which the BPILX sequences are fused to the C-terminus of the GST (glutathione S-transferase) sequences. Such fusion proteins can facilitate the purification of recombinant BPILX polypeptides. In another embodiment, the fusion protein is a BPILX protein containing a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression and/or secretion of BPILX can be increased through use of a heterologous signal sequence.
In yet another embodiment, the fusion protein is a BPILX-immunoglobulin fusion protein in which the BPILX sequences are fused to sequences derived from a member of the immunoglobulin protein family. The BPILX-immunoglobulin fusion proteins of the invention can be incoφorated into pharmaceutical compositions and administered to a subject to inhibit an interaction between a BPILX ligand and a BPILX protein on the surface of a cell, to thereby suppress BPILX-mediated signal transduction in vivo. The BPILX-immunoglobulin fusion proteins can be used to affect the bioavailabihty of a BPILX cognate ligand. Inhibition of the BPILX ligand BPILX interaction can be useful therapeutically for both the treatment of proliferative and differentiative disorders, as well as modulating (e.g. promoting or inhibiting) cell survival. Moreover, the BPILX-immunoglobulin fusion proteins of the invention can be used as immunogens to produce anti-BPILX antibodies in a subject, to purify BPILX ligands, and in screening assays to identify molecules that inhibit the interaction of BPILX with a BPILX ligand. A BPILX chimeric or fusion protein of the invention can be produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, e.g., by employing blunt- ended or stagger-ended termini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers that give rise to complementary overhangs between two consecutive gene fragments that can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, e.g., Ausubel, et al. (eds.)
CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). A BPILX-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the BPILX protein. THREE DIMENSIONAL STRUCTURAL ANALYSIS
The predicted three-dimensional structure of BPILX, generated by the GeneAtlas™ program (MSI) (as described in the Examples) which includes fold predictions from Fischer and Eisensberg (Protein Science 5:947-955, 1996) and homology models from Sanchez and Sali (Proc. Nad. Acad. Sci.. 95: 13597-13602, 1998), suggests BPILX is structurally related to bactericidal permeability increasing protein (BPI) . This analysis can be used to predict residues potentially involved in ligand-receptor binding and other residues important to BPILX biological function. The three-dimensional structure of BPILX will be useful in developing modulators of BPILX activity such as antibodies, small molecules, peptides and derivatives thereof. The three-dimensional structure of BPILX may be generated using the structural coordinates set forth in Tables 49-59 . In addition, it is understood in the art that molecules or molecular complexes that are defined by the structural coordinates of Tables 49-59 include those plus or minus a root mean square deviation from the conserved backbone atoms of those amino acids of 2-12 A, preferably not more than about 7 A, or more preferably not more than about 5 A, or most preferably not more than about 2 A.
Identification of binding pocket residues and other residues important to BPILX biological function will be useful in discovering drugs which may modulate (i.e. increase or decrease) activity of BPILX. Small molecules, antibodies and peptides which associate with one or more, or two or more, or three or more, or four or more, or five or more or 10 or more, 15 or more, or 20 or more of the binding pocket residues or with other regions of BPILX may modulate BPILX activity, e.g., by increasing or decreasing its affinity for the BPILX. An understanding of the binding pocket residues and associations that occur with these residues will facilitate the development of modulators (including antagonists and agonists) of BPILX activity, including BPILX ligand binding. The "binding pocket residues" of BPILX refer to the amino acid residues of the BPILX molecule which interact with any ligand or receptor to which BPILX binds. These amino acids preferably include the annotated amino acid residues depicted in Tables of Primary Sequence Alignment and Secondary Structure (e.g., Tables 7 and 8) and the underlined amino acids in binding pocket Tables (e.g., Tables 9-12) and other amino acids within 2-12 angstroms, preferably within 7 angstroms, or more preferably within 5 A, that may interact with these listed amino acids and/or contribute to the three-dimensional conformation of these listed amino acids. For example, these include amino acid val26, leu29, val37, ser 38, ile40 and pro44 of SEQ ID NO:2 as illustrated by underlining in Table 9 (SEQ ID NO: )
A "BPILX ligand" refers to any compound (e.g., polypeptide, or lipid) that may bind to the BPILX polypeptide. The BPILX three-dimensional structure allows for the generation of polypeptide variants or non-peptidyl compounds that mimic the three-dimensional structure of BPILX. The BPILX three- dimensional structure also allows fur the identification of desirable sites for mutation to Create polypeptide or non-peptidyl variants with similar, increased, decreased or different biological activity compared to wild type BPILX. Through site-directed mutagenesis, binding pocket residues or other residues involved in BPILX biological function may be mutated to create modulators of BPILX activity. The mutants may act as antagonists or agonists for BPILX. These mutants may be useful in therapeutic compositions directed to modulating the activity of BPILX or BPILX ligands. These mutations can be deletions, additions or substitutions of receptor binding residues, accessory protein binding residues or other residues important to BPILX biological function. Non- conservative substitutions are expected to be more likely to result in different biological activity compared to wild type BPILX. For example, mutations may alter the surface charge of BPILX which may alter the biological activity of BPILX. Other mutations may affect the ability of BPILX variants to bind to BPILX ligands or receptors to which BPILX bind or ability to antagonize BPILX. The effect or various mutations on BPILX activity can be modeled in three- dimensional representations on a computer using any of the computer programs described herein. Molecular modeling may be carried out using, e.g., the structural coordinates described herein, and any computer programs known in the art. For example, programs which predict binding sites and aid in designing modulators based on three-dimensional structural models include, but are not limited to, GRID (Oxford University) which aids in determining energetically favorable binding sites (Goodford, J. Med. Cham. 28: 849-857, 1985), MCSS (Molecular Simulations, Burlington, MA) which aids in determining functional maps of binding sites (Miranker and Kaφlus. Proteins. Structure, Function, and Genetics, 11 : 29-34, 1991), AUTODOCK (Scripps Research) which aids in automated docking of substrates to proteins (Goodsell and Olsen, Proteins, Structure, Function, and Genetics, 8: 195-202. 1990, DOCK (University of San Francisco) which aids in determining macromolecular-ligand interactions (Kuntz et al., J. Mol. Biol. 161 : 269-288, 1982). The term "structure coordinates" refers to Cartesian coordinates derived from mathematical equations to generate the three-dimensional model of BPILX as modeled derived from its primary amino acid sequence using, e.g, the GeneAtlas™ program. The model is used to establish the positions of the individual atoms of the BPILX protein. Those of skill in the art understand that a set of structure coordinates for a molecule or a portion thereof is a relative set of points that define a structure in three dimensions. Thus, it is possible that an entirely different set of coordinates could define a similar structure. Moreover, slight variations in the individual coordinates will have little effect on overall shape. Variations in coordinates may be generated by mathematical manipulations of the structural coordinates, e.g., by permutations of the structure coordinates, fractionalization of the structure coordinates, integer additions or subtractions to sets of the structure coordinates, inversion of the structure coordinates or any combination of the above.
Various computational analyses may be done to determine whether a molecule or a portion thereof is sufficiently similar, e.g, using current software applications, such as the Molecular Similarity application of QUANTA (Molecular Simulations Inc., 20 San Diego, Calif.) version 4. 1. and as described in the accompanying User's Guide.
The term "root mean square deviation" means the square root of the arithmetic mean of the squares of the deviations from the mean and is a way to express the deviation of variation from a trend or object. For puφoses of the invention, the "root mean square deviation" defines the variation in the backbone of a protein from the polypeptide backbone of BPILX or a portion thereof or selected residues thereof, as substantially defined by the structural coordinates in Tables 49-59 below. USES AND BIOLOGICAL ACTIVITY
The polynucleotides and proteins of the present invention are expected to exhibit one or more of the uses or biological activities (including those associated with assays cited herein) identified below. Uses or activities described for proteins of the present invention may be provided by administration or use of such proteins or by administration or use of polynucleotides encoding such proteins (such as, for example, in gene therapies or vectors suitable for introduction of DNA).
RESEARCH USES AND UTILITIES The polynucleotides provided by the present invention can be used by the research community for various puφoses. The polynucleotides can be used to express recombinant protein for analysis, characterization or therapeutic use; as markers for tissues in which the corresponding protein is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in disease states); as molecular weight markers on Southern gels; as chromosome markers or tags (when labeled) to identify chromosomes or to map related gene positions; to compare with endogenous DNA sequences in patients to identify potential genetic disorders; as probes to hybridize and thus discover novel, related DNA sequences; as a source of information to derive PCR primers for genetic fingeφrinting; as a probe to "subtract-out" known sequences in the process of discovering other novel polynucleotides; for selecting and making oligomers for attachment to a "gene chip" or other support, including for examination of expression patterns; to raise anti-protein antibodies using DNA immunization techniques; and as an antigen to raise anti-DNA antibodies or elicit another immune response. Where the polynucleotide encodes a protein which binds or potentially binds to another protein (such as, for example, in a receptor- ligand interaction), the polynucleotide can also be used in interaction trap assays (such as, for example, that described in Gyuris et al., Cell 75:791-803 (1993)) to identify polynucleotides encoding the other protein with which binding occurs or to identify inhibitors of the binding interaction.
The proteins provided by the present invention can similarly be used in assay to determine biological activity, including in a panel of multiple proteins for high-throughput screening; to raise antibodies or to elicit another immune response; as a reagent (including the labeled reagent) in assays designed to quantitatively determine levels of the protein (or its receptor) in biological fluids; as markers for tissues in which the corresponding protein is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in a disease state); and, of course, to isolate correlative receptors or ligands. Where the protein binds or potentially binds to another protein (such as, for example, in a receptor-ligand interaction), the protein can be used to identify the other protein with which binding occurs or to identify inhibitors of the binding interaction. Proteins involved in these binding interactions can also be used to screen for peptide or small molecule inhibitors or agonists of the binding interaction. Any or all of these research utilities are capable of being developed into reagent grade or kit format for commercialization as research products. Methods for performing the uses listed above are well known to those skilled in the art. References disclosing such methods include without limitation "Molecular Cloning: A Laboratory Manual", 2d ed., Cold Spring Harbor Laboratory Press, Sambrook, J., E. F. Fritsch and T. Maniatis eds., 1989, and "Methods in Enzymology: Guide to Molecular Cloning Techniques", Academic Press, Berger, S. L. and A. R. Kimmel eds., 1987.
ANTIMICROBIAL ACTIVITY
The polypeptides, polynucleotides and antibodies of the invention can be utilized, for example, as part of methods for modulating host responses to Gram-negative bacterial infections. The polypeptides and antibodies of the invention may be capable of binding to bacterial glycolipids called lipopolysaccharides (LPS). In addition to binding to LPS, the polypeptides and polynucleotides of the invention are potently bactericidal to Gram-negative bacteria, and therefore, have numerous potential therapeutic applications. Specifically, for example, the polypeptides, polynucleotides and antibodies of the invention can be used in the treatment of infections and conditions associated with bacteremia and endotoxemia. Moreover, the polypeptides, polynucleotides and antibodies of the invention may act synergistically with a broad range of antibiotics, to increase the effectiveness of the antibiotics, including some of which the target bacteria may be resistant to. The polypeptides, polynucleotides and antibodies of the invention can further be utilized to modulate LPS-induced secretion of various cytokines and/or growth factors, including, but not limited to, TNF-α, IL-6, IFN-β and NO.
CANCER DIAGNOSIS AND THERAPY
Polypeptides of the invention may be involved in cancer cell generation, proliferation or metastasis. Detection of the presence or amount of polynucleotides or polypeptides of the invention may be useful for the diagnosis and/or prognosis of one or more types of cancer. For example, the presence or increased expression of a polynucleotide/polypeptide of the invention may indicate a hereditary risk of cancer, a precancerous condition, or an ongoing malignancy.
Conversely, a defect in the gene or absence of the polypeptide may be associated with a cancer condition. Identification of single nucleotide polymoφhisms associated with cancer or a predisposition to cancer may also be useful for diagnosis or prognosis. Cancer treatments promote tumor regression by inhibiting tumor cell proliferation, inhibiting angiogenesis (growth of new blood vessels that is necessary to support tumor growth) and or prohibiting metastasis by reducing tumor cell motility or invasiveness. Therapeutic compositions of the invention may be effective in adult and pediatric oncology including in solid phase tumors/malignancies, locally advanced tumors, human soft tissue sarcomas, metastatic cancer, including lymphatic metastases, blood cell malignancies including multiple myeloma, acute and chronic leukemias, and lymphomas, head and neck cancers including mouth cancer, larynx cancer and thyroid cancer, lung cancers including small cell carcinoma and non-small cell cancers, breast cancers including small cell carcinoma and ductal carcinoma, gastrointestinal cancers including esophageal cancer, stomach cancer, colon cancer, colorectal cancer and polyps associated with colorectal neoplasia, pancreatic cancers, liver cancer, urologic cancers including bladder cancer and prostate cancer, malignancies of the female genital tract including ovarian carcinoma, uterine (including endometrial) cancers, and solid tumor in the ovarian follicle, kidney cancers including renal cell carcinoma, brain cancers including intrinsic brain tumors, neuroblastoma, astrocytic brain tumors, gliomas, metastatic tumor cell invasion in the central nervous system, bone cancers including osteomas, skin cancers including malignant melanoma, tumor progression of human skin keratinocytes, squamous cell carcinoma, basal cell carcinoma, hemangiopericytoma and Kaφosi's sarcoma.
Polypeptides, polynucleotides, or modulators of polypeptides of the invention (including inhibitors and stimulators of the biological activity of the polypeptide of the invention) may be administered to treat cancer. Therapeutic compositions can be administered in therapeutically effective dosages alone or in combination with adjuvant cancer therapy such as surgery, chemotherapy, radiotherapy, thermotherapy, and laser therapy, and may provide a beneficial effect, e.g. reducing tumor size, slowing rate of tumor growth, inhibiting metastasis, or otherwise improving overall clinical condition, without necessarily eradicating the cancer.
The composition can also be administered in therapeutically effective amounts as a portion of an anti-cancer cocktail. An anti-cancer cocktail is a mixture of the polypeptide or modulator of the invention with one or more anti-cancer drugs in addition to a pharmaceutically acceptable carrier for delivery. The use of anti-cancer cocktails as a cancer treatment is routine. Anti-cancer drugs that are well known in the art and can be used as a treatment in combination with the polypeptide or modulator of the invention include: Actinomycin D, Aminoglutethimide, Asparaginase, Bleomycin, Busulfan, Carboplatin, Carmustine, Chlorambucil, Cisplatin (cis-DDP), Cyclophosphamide, Cytarabine HCl (Cytosine arabinoside), Dacarbazine, Dactinomycin, Daunorubicin HCl, Doxorubicin HCl, Estramustine phosphate sodium, Etoposide (VI 6-213), Floxuridine, 5-Fluorouracil (5-Fu), Flutamide, Hydroxyurea (hydroxycarbamide), Ifosfamide, Interferon Alpha-2a, Interferon Alpha-2b, Leuprolide acetate (LHRH-releasing factor analog), Lomustine, Mechlorethamine HCl (nitrogen mustard), Melphalan, Mercaptopurine, Mesna, Methotrexate (MTX), Mitomycin, Mitoxantrone HCl, Octreotide, Plicamycin, Procarbazine HCl, Streptozocin, Tamoxifen citrate, Thioguanine, Thiotepa, Vinblastine sulfate, Vincristine sulfate, Amsacrine, Azacitidine, Hexamethylmelamine, Interleukin-2, Mitoguazone, Pentostatin, Semustine, Teniposide, and Vindesine sulfate.
In addition, therapeutic compositions of the invention may be used for prophylactic treatment of cancer. There are hereditary conditions and/or environmental situations (e.g. exposure to carcinogens) known in the art that predispose an individual to developing cancers. Under these circumstances, it may be beneficial to treat these individuals with therapeutically effective doses of the polypeptide of the invention to reduce the risk of developing cancers.
In vitro models can be used to determine the effective doses of the polypeptide of the invention as a potential cancer treatment. These in vitro models include proliferation assays of cultured tumor cells, growth of cultured tumor cells in soft agar (see Freshney, (1987) Culture of Animal Cells: A Manual of Basic Technique, Wily-Liss, New York, NY Ch 18 and Ch 21), tumor systems in nude mice as described in Giovanella et al., J. Natl. Can. Inst., 52: 921-30 (1974), mobility and invasive potential of tumor cells in Boyden Chamber assays as described in Pilkington et al., Anticancer Res., 17: 4107-9 (1997), and angiogenesis assays such as induction of vascularization of the chick chorioallantoic membrane or induction of vascular endothelial cell migration as described in Ribatta et al., Intl. J. Dev. Biol., 40: 1189-97 (1999) and Li et al., Clin. Exp. Metastasis, 17:423-9 (1999) respectively. Suitable tumor cells lines are available, e.g. from American Type Tissue Culture Collection catalogs.
CYTOKINE AND CELL PROLIFERATION/DIFFERENTIATION ACTIVITY
A protein of the present invention may exhibit cytokine, cell proliferation (either inducing or inhibiting) or cell differentiation (either inducing or inhibiting) activity or may induce production of other cytokines in certain cell populations. A polynucleotide of the invention can encode a polypeptide exhibiting such attributes. Many protein factors discovered to date, including all known cytokines, have exhibited activity in one or more factor-dependent cell proliferation assays, and hence the assays serve as a convenient confirmation of cytokine activity. The activity of a protein of the present invention is evidenced by any one of a number of routine factor dependent cell proliferation assays for cell lines including, without limitation, 32D, DA2, DA1G, T10, B9, B9/11, BaF3, MC9/G, M+(preB M+), 2E8, RB5, DAI, 123, TI 165, HT2, CTLL2, TF-1, Mo7e and CMK.
The activity of a protein of the invention may, among other means, be measured by the following methods:
Assays for T-cell or thymocyte proliferation include without limitation those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-3.19; Chapter 7, Immunologic studies in Humans); Takai et al., J. Immunol. 137:3494-3500, 1986; Bertagnolli et al., J. Immunol. 145: 1706- 1712, 1990; Bertagnolli et al., Cellular Immunology 133:327-341, 1991; Bertagnolli, et al., I. Immunol. 149:3778-3783, 1992; Bowman et al., I. Immunol. 152:1756-1761, 1994. Assays for cytokine production and/or proliferation of spleen cells, lymph node cells or thymocytes include, without limitation, those described in: Polyclonal T cell stimulation, Kruisbeek, A. M. and Shevach, E. M. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 3.12.1-3.12.14, John Wiley and Sons, Toronto. 1994; and Measurement of mouse and human interleukin gamma, Schreiber, R. D. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 6.8.1-6.8.8, John Wiley and Sons, Toronto. 1994.
Assays for proliferation and differentiation of hematopoietic and lymphopoietic cells include, without limitation, those described in: Measurement of Human and Murine Interleukin 2 and Interleukin 4, Bottomly, K., Davis, L. S. and Lipsky, P. E. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 6.3.1-6.3.12, John Wiley and Sons, Toronto. 1991; deVries et al., J. Exp. Med. 173:1205-1211, 1991; Moreau et al., Nature 336:690-692, 1988;
Greenberger et al., Proc. Natl. Acad. Sci. U.S.A. 80:2931-2938, 1983; Measurement of mouse and human interleukin 6~Nordan, R. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 6.6.1-6.6.5, John Wiley and Sons, Toronto. 1991; Smith et al., Proc. Natl. Aced. Sci. U.S.A. 83:1857-1861, 1986; Measurement of human Interleukin l l--Bennett, F., Giannotti, J., Clark, S. C. and Turner, K. J. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 6.15.1 John Wiley and Sons, Toronto. 1991; Measurement of mouse and human Interleukin 9-Ciarletta, A., Giannotti, J., Clark, S. C. and Turner, K. J. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 6.13.1, John Wiley and Sons, Toronto. 1991.
Assays for T-cell clone responses to antigens (which will identify, among others, proteins that affect APC-T cell interactions as well as direct T-cell effects by measuring proliferation and cytokine production) include, without limitation, those described in: Current Protocols in
Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function; Chapter 6, Cytokines and their cellular receptors; Chapter 7, Immunologic studies in Humans); Weinberger et al., Proc. Natl. Acad. Sci. USA 77:6091 -6095, 1980; Weinberger et al., Eur. J. Immun. 11 :405-411, 1981; Takai et al., J. Immunol. 137:3494-3500, 1986; Takai et al., J. Immunol. 140:508-512, 1988.
IMMUNE STIMULATING OR SUPPRESSING ACTIVITY
A protein of the present invention may also exhibit immune stimulating or immune suppressing activity, including without limitation the activities for which assays are described herein. A polynucleotide of the invention can encode a polypeptide exhibiting such activities. A protein may be useful in the treatment of various immune deficiencies and disorders (including severe combined immunodeficiency (SCID)), e.g., in regulating (up or down) growth and proliferation of T and/or B lymphocytes, as well as effecting the cytolytic activity of NK cells and other cell populations. These immune deficiencies may be genetic or be caused by vital (e.g., HIV) as well as bacterial or fungal infections, or may result from autoimmune disorders. More specifically, infectious diseases causes by viral, bacterial, fungal or other infection may be treatable using a protein of the present invention, including infections by HIV, hepatitis viruses, heφesviruses, mycobacteria, Leishmania spp., malaria spp. and various fungal infections such as candidiasis. Of course, in this regard, a protein of the present invention may also be useful where a boost to the immune system generally may be desirable, i.e., in the treatment of cancer.
Autoimmune disorders which may be treated using a protein of the present invention include, for example, connective tissue disease, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes mellitis, myasthenia gravis, graft-versus-host disease and autoimmune inflammatory eye disease. Such a protein of the present invention may also to be useful in the treatment of allergic reactions and conditions, such as asthma (particularly allergic asthma) or other respiratory problems. Other conditions, in which immune suppression is desired (including, for example, organ transplantation), may also be treatable using a protein of the present invention. Using the proteins of the invention it may also be possible to immune responses, in a number of ways. Down regulation may be in the form of inhibiting or blocking an immune response already in progress or may involve preventing the induction of an immune response. The functions of activated T cells may be inhibited by suppressing T cell responses or by inducing specific tolerance in T cells, or both. Immunosuppression of T cell responses is generally an active, non-antigen-specific, process which requires continuous exposure of the T cells to the suppressive agent. Tolerance, which involves inducing non-responsiveness or anergy in T cells, is distinguishable from immunosuppression in that it is generally antigen-specific and persists after exposure to the tolerizing agent has ceased. Operationally, tolerance can be demonstrated by the lack of a T cell response upon reexposure to specific antigen in the absence of the tolerizing agent.
Down regulating or preventing one or more antigen functions (including without limitation B lymphocyte antigen functions (such as, for example, B7)), e.g., preventing high level lymphokine synthesis by activated T cells, will be useful in situations of tissue, skin and organ transplantation and in graft-versus-host disease (GVHD). For example, blockage of T cell function should result in reduced tissue destruction in tissue transplantation. Typically, in tissue transplants, rejection of the transplant is initiated through its recognition as foreign by T cells, followed by an immune reaction that destroys the transplant. The administration of a molecule which inhibits or blocks interaction of a B7 lymphocyte antigen with its natural ligand(s) on immune cells (such as a soluble, monomeric form of a peptide having B7-2 activity alone or in conjunction with a monomeric form of a peptide having an activity of another B lymphocyte antigen (e.g., B7-1, B7-3) or blocking antibody), prior to transplantation can lead to the binding of the molecule to the natural ligand(s) on the immune cells without transmitting the coπesponding costimulatory signal. Blocking B lymphocyte antigen function in this matter prevents cytokine synthesis by immune cells, such as T cells, and thus acts as an immunosuppressant. Moreover, the lack of costimulation may also be sufficient to anergize the T cells, thereby inducing tolerance in a subject. Induction of long-term tolerance by B lymphocyte antigen-blocking reagents may avoid the necessity of repeated administration of these blocking reagents. To achieve sufficient immunosuppression or tolerance in a subject, it may also be necessary to block the function of a combination of B lymphocyte antigens.
The efficacy of particular blocking reagents in preventing organ transplant rejection or GVHD can be assessed using animal models that are predictive of efficacy in humans. Examples of appropriate systems which can be used include allogeneic cardiac grafts in rats and xenogeneic pancreatic islet cell grafts in mice, both of which have been used to examine the immunosuppressive effects of CTLA4Ig fusion proteins in vivo as described in Lenschow et al., Science 257:789-792 (1992) and Turka et al., Proc. Natl. Acad. Sci USA, 89:11102-11105 (1992). In addition, murine models of GVHD (see Paul ed., Fundamental Immunology, Raven Press, New York, 1989, pp. 846-847) can be used to determine the effect of blocking B lymphocyte antigen function in vivo on the development of that disease.
Blocking antigen function may also be therapeutically useful for treating autoimmune diseases. Many autoimmune disorders are the result of inappropriate activation of T cells that are reactive against self tissue and which promote the production of cytokines and autoantibodies involved in the pathology of the diseases. Preventing the activation of autoreactive T cells may reduce or eliminate disease symptoms. Administration of reagents which block costimulation of T cells by disrupting receptor:ligand interactions of B lymphocyte antigens can be used to inhibit T cell activation and prevent production of autoantibodies or T cell-derived cytokines which may be involved in the disease process. Additionally, blocking reagents may induce antigen-specific tolerance of autoreactive T cells which could lead to long-term relief from the disease. The efficacy of blocking reagents in preventing or alleviating autoimmune disorders can be determined using a number of well-characterized animal models of human autoimmune diseases. Examples include murine experimental autoimmune encephalitis, systemic lupus erythmatosis in MRL/lpr/lpr mice or NZB hybrid mice, murine autoimmune collagen arthritis, diabetes mellitus in NOD mice and BB rats, and murine experimental myasthenia gravis (see Paul ed., Fundamental Immunology, Raven Press, New York, 1989, pp. 840-856).
Upregulation of an antigen function (preferably a B lymphocyte antigen function), as a means of up regulating immune responses, may also be useful in therapy. Upregulation of immune responses may be in the form of enhancing an existing immune response or eliciting an initial immune response. For example, enhancing an immune response through stimulating B lymphocyte antigen function may be useful in cases of viral infection. In addition, systemic viral diseases such as influenza, the common cold, and encephalitis might be alleviated by the administration of stimulatory forms of B lymphocyte antigens systemically.
Alternatively, anti-vital immune responses may be enhanced in an infected patient by removing T cells from the patient, costimulating the T cells in vitro with viral antigen-pulsed APCs either expressing a peptide of the present invention or together with a stimulatory form of a soluble peptide of the present invention and reintroducing the in vitro activated T cells into the patient. Another method of enhancing anti-viral immune responses would be to isolate infected cells from a patient, transfect them with a nucleic acid encoding a protein of the present invention as described herein such that the cells express all or a portion of the protein on their surface, and reintroduce the transfected cells into the patient. The infected cells would now be capable of delivering a costimulatory signal to, and thereby activate, T cells in vivo.
The presence of the peptide of the present invention having the activity of a B lymphocyte antigen(s) on the surface of the tumor cell provides the necessary costimulation signal to T cells to induce a T cell mediated immune response against the transfected tumor cells. In addition, tumor cells which lack MHC class I or MHC class II molecules, or which fail to reexpress sufficient mounts of MHC class I or MHC class II molecules, can be transfected with nucleic acid encoding all or a portion of (e.g., a cytoplasmic-domain truncated portion) of an MHC class I ? .alpha, chain protein and .beta.. sub.2 microglobulin protein or an MHC class II .alpha, chain protein and an MHC class II .beta, chain protein to thereby express MHC class I or MHC class II proteins on the cell surface. Expression of the appropriate class I or class II MHC in conjunction with a peptide having the activity of a B lymphocyte antigen (e.g., B7-1, B7-2, B7-3) induces a T cell mediated immune response against the transfected tumor cell. Optionally, a gene encoding an antisense construct which blocks expression of an MHC class II associated protein, such as the invariant chain, can also be cotransfected with a DNA encoding a peptide having the activity of a B lymphocyte antigen to promote presentation of tumor associated antigens and induce tumor specific immunity. Thus, the induction of a T cell mediated immune response in a human subject may be sufficient to overcome tumor-specific tolerance in the subject.
The activity of a protein of the invention may, among other means, be measured by the following methods: Suitable assays for thymocyte or splenocyte cytotoxicity include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-3.19; Chapter 7, Immuno logic studies in Humans); Herrmann et al., Proc. Natl. Acad. Sci. USA 78:2488-2492, 1981; Herrmann et al., J. Immunol. 128:1968-1974, 1982; Handa et al., J. Immunol. 135:1564-1572, 1985; Takai et al., I. Immunol. 137:3494-3500, 1986; Takai et al., J. Immunol. 140:508-512, 1988; Herrmann et al., Proc. Natl. Acad. Sci. USA 78:2488-2492, 1981 ; Herrmann et al., J. Immunol. 128:1968-1974, 1982; Handa et al., J. Immunol. 135:1564-1572, 1985; Takai et al., J. Immunol. 137:3494-3500, 1986; Bowmanet al., J. Virology 61 :1992-1998; Takai et al., J. Immunol. 140:508-512, 1988; Bertagnolli et al., Cellular Immunology 133:327-341, 1991 ; Brown et al., J. Immunol. 153:3079- 3092, 1994.
Assays for T-cell-dependent immunoglobulin responses and isotype switching (which will identify, among others, proteins that modulate T-cell dependent antibody responses and that affect Thl/Th2 profiles) include, without limitation, those described in: Maliszewski, J. Immunol.
144:3028-3033, 1990; and Assays for B cell function: In vitro antibody production, Mond, J. J. and Brunswick, M. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 3.8.1-3.8.16, John Wiley and Sons, Toronto. 1994.
Mixed lymphocyte reaction (MLR) assays (which will identify, among others, proteins that generate predominantly Thl and CTL responses) include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-3.19; Chapter 7, Immunologic studies in Humans); Takai et al., J. Immunol. 137:3494-3500, 1986; Takai et al., J. Immunol. 140:508-512, 1988; Bertagnolli et al., J. Immunol. 149:3778-3783, 1992.
Dendritic cell-dependent assays (which will identify, among others, proteins expressed by dendritic cells that activate naive T-cells) include, without limitation, those described in: Guery et al., J. Immunol. 134:536-544, 1995; Inaba et al., Journal of Experimental Medicine 173:549-559, 1991; Macatonia et al., Journal of Immunology 154:5071-5079, 1995; Porgador et al., Journal of Experimental Medicine 182:255-260, 1995; Nair et al., Journal of Virology 67:4062-4069, 1993; Huang et al., Science 264:961-965, 1994; Macatonia et al., Journal of Experimental Medicine 169:1255-1264, 1989; Bhardwaj et al., Journal of Clinical Investigation 94:797-807, 1994; and
Inaba et al., Journal of Experimental Medicine 172:631-640, 1990.
Assays for lymphocyte survival/apoptosis (which will identify, among others, proteins that prevent apoptosis after superantigen induction and proteins that regulate lymphocyte homeostasis) include, without limitation, those described in: Darzynkiewicz et al., Cytometry 13:795-808, 1992;
Gorczyca et al., Leukemia 7:659-670, 1993; Gorczyca et al., Cancer Research 53:1945-1951, 1993;
Itoh et al., Cell 66:233-243, 1991; Zacharchuk, Journal of Immunology 145:4037-4045, 1990;
Zamai et al., Cytometry 14:891-897, 1993; Gorczyca et al., International Journal of Oncology
1:639-648, 1992. Assays for proteins that influence early steps of T-cell commitment and development include, without limitation, those described in: Antica et al., Blood 84:11 1-117, 1994; Fine et al.,
Cellular Immunology 155:111-122, 1994; Galy et al., Blood 85:2770-2778, 1995; Toki et al., Proc.
Nat. Acad Sci. USA 88:7548-7551, 1991.
HEMOSTATIC AND THROMBOLYTIC ACTIVITY A protein of the invention may also exhibit hemostatic or thrombolytic activity. A polynucleotide of the invention can encode a polypeptide exhibiting such attributes. Such a protein is expected to be useful in treatment of various coagulation disorders (including hereditary disorders, such as hemophilias) or to enhance coagulation and other hemostatic events in treating wounds resulting from trauma, surgery or other causes. A protein of the invention may also be useful for dissolving or inhibiting formation of thromboses and for treatment and prevention of conditions resulting therefrom (such as, for example, infarction of cardiac and central nervous system vessels (e.g., stroke).
The activity of a protein of the invention may, among other means, be measured by the following methods: Assay for hemostatic and thrombolytic activity include, without limitation, those described in: Linet et al., J. Clin. Pharmacol. 26:131-140, 1986; Burdick et al., Thrombosis Res. 45:413-419,
1987; Humphrey et al., Fibrinolysis 5:71-79 (1991); Schaub, Prostaglandins 35:467-474, 1988.
HEMATOPOIESIS REGULATING ACTIVITY
A protein of the present invention may be useful in regulation of hematopoiesis and, consequently, in the treatment of myeloid or lymphoid cell deficiencies. Even marginal biological activity in support of colony forming cells or of factor-dependent cell lines indicates involvement in regulating hematopoiesis, e.g. in supporting the growth and proliferation of erythroid progenitor cells alone or in combination with other cytokines, thereby indicating utility, for example, in treating various anemias or for use in conjunction with irradiation/chemotherapy to stimulate the production of erythroid precursors and/or erythroid cells; in supporting the growth and proliferation of myeloid cells such as granulocytes and monocytes/macrophages (i.e., traditional CSF activity) useful, for example, in conjunction with chemotherapy to prevent or treat consequent myelo- suppression; in supporting the growth and proliferation of megakaryocytes and consequently of platelets thereby allowing prevention or treatment of various platelet disorders such as thrombocytopenia, and generally for use in place of or complimentary to platelet transfusions; and/or in supporting the growth and proliferation of hematopoietic stem cells which are capable of maturing to any and all of the above-mentioned hematopoietic cells and therefore find therapeutic utility in various stem cell disorders (such as those usually treated with transplantation, including, without limitation, aplastic anemia and paroxysmal nocturnal hemoglobinuria), as well as in repopulating the stem cell compartment post irradiation/chemotherapy, either in-vivo or ex-vivo (i.e., in conjunction with bone marrow transplantation or with peripheral progenitor cell transplantation (homologous or heterologous)) as normal cells or genetically manipulated for gene therapy.
The activity of a protein of the invention may, among other means, be measured by the following methods: Suitable assays for proliferation and differentiation of various hematopoietic lines are cited above. Assays for embryonic stem cell differentiation (which will identify, among others, proteins that influence embryonic differentiation hematopoiesis) include, without limitation, those described in: Johansson et al. Cellular Biology 15:141-151, 1995; Keller et al., Molecular and Cellular Biology 13:473-486, 1993; McClanahan et al., Blood 81:2903-2915, 1993. Assays for stem cell survival and differentiation (which will identify, among others, proteins that regulate lympho-hematopoiesis) include, without limitation, those described in: Methylcellulose colony forming assays, Freshney, M. G. In Culture of Hematopoietic Cells. R. I. Freshney, et al. eds. Vol pp. 265-268, Wiley-Liss, Inc., New York, N.Y. 1994; Hirayama et al., Proc. Natl. Acad. Sci. USA 89:5907-5911, 1992; Primitive hematopoietic colony forming cells with high proliferative potential, McNiece, I. K. and Briddell, R. A. In Culture of Hematopoietic Cells. R. I. Freshney, et al. eds. Vol pp. 23-39, Wiley-Liss, Inc., New York, N.Y. 1994; Neben et al., Experimental Hematology 22:353-359, 1994; Cobblestone area forming cell assay, Ploemacher, R. E. In Culture of Hematopoietic Cells. R. I. Freshney, et al. eds. Vol pp. 1-21, Wiley-Liss, Inc., New York, N.Y. 1994; Long term bone maπow cultures in the presence of stromal cells, Spooncer, E., Dexter, M. and Allen, T. In Culture of Hematopoietic Cells. R. I. Freshney, et al. eds. Vol pp. 163-179, Wiley-Liss, Inc., New York, N.Y. 1994; Long term culture initiating cell assay,
Sutherland, H. J. In Culture of Hematopoietic Cells. R. I. Freshney, et al. eds. Vol pp. 139-162, Wiley-Liss, Inc., New York, N.Y. 1994.
CHEMOTACTIC/CHEMOKINETIC ACTIVITY A protein of the present invention may have chemotactic or chemokinetic activity (e.g., act as a chemokine) for mammalian cells, including, for example, monocytes, fibroblasts, neutrophils, T-cells, mast cells, eosinophils, epithelial and/or endothelial cells. A polynucleotide of the invention can encode a polypeptide exhibiting such attributes. Chemotactic and chemokinetic proteins can be used to mobilize or attract a desired cell population to a desired site of action. Chemotactic or chemokinetic proteins provide particular advantages in treatment of wounds and other trauma to tissues, as well as in treatment of localized infections. For example, attraction of lymphocytes, monocytes or neutrophils to tumors or sites of infection may result in improved immune responses against the tumor or infecting agent.
A protein or peptide has chemotactic activity for a particular cell population if it can stimulate, directly or indirectly, the directed orientation or movement of such cell population. Preferably, the protein or peptide has the ability to directly stimulate directed movement of cells. Whether a particular protein has chemotactic activity for a population of cells can be readily determined by employing such protein or peptide in any known assay for cell chemotaxis. The activity of a protein of the invention may, among other means, be measured by the following methods:
Assays for chemotactic activity (which will identify proteins that induce or prevent chemotaxis) consist of assays that measure the ability of a protein to induce the migration of cells across a membrane as well as the ability of a protein to induce the adhesion of one cell population to another cell population. Suitable assays for movement and adhesion include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Marguiles, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 6.12, Measurement of alpha and beta Chemokines 6.12.1-6.12.28; Taub et al. J. Clin.
Invest. 95:1370-1376, 1995; Lind et al. APMIS 103:140-146, 1995; Muller et al Eur. J. Immunol.
25:1744-1748; Gruber et al. J. of Immunol. 152:5860-5867, 1994; Johnston et al. J. of Immunol.
153:1762-1768, 1994.
RECEPTOR/LIGAND ACTIVITY
A protein of the present invention may also demonstrate activity as receptors, receptor ligands or inhibitors or agonists of receptor/ligand interactions. A polynucleotide of the invention can encode a polypeptide exhibiting such characteristics. Examples of such receptors and ligands include, without limitation, cytokine receptors and their ligands, receptor kinases and their ligands, receptor phosphatases and their ligands, receptors involved in cell-cell interactions and their ligands (including without limitation, cellular adhesion molecules (such as selectins, integrins and their ligands) and receptor/ligand pairs involved in antigen presentation, antigen recognition and development of cellular and humoral immune responses). Receptors and ligands are also useful for screening of potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction. A protein of the present invention (including, without limitation, fragments of receptors and ligands) may themselves be useful as inhibitors of receptor/ligand interactions.
The activity of a protein of the invention may, among other means, be measured by the following methods: Suitable assays for receptor-ligand activity include without limitation those described in:
Cuπent Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M.
Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 7.28,
Measurement of Cellular Adhesion under static conditions 7.28.1-7.28.22), Takai et al., Proc. Natl.
Acad. Sci. USA 84:6864-6868, 1987; Bierer et al., J. Exp. Med. 168:1145-1156, 1988; Rosenstein et al., J. Exp. Med. 169:149-160 1989; Stoltenborg et al., J. Immunol. Methods 175:59-68, 1994;
Stitt et al., Cell 80:661-670, 1995.
ANTI-INFLAMMATORY ACTIVITY
Proteins of the present invention may also exhibit anti-inflammatory activity. The anti- inflammatory activity may be achieved by providing a stimulus to cells involved in the inflammatory response, by inhibiting or promoting cell-cell interactions (such as, for example, cell adhesion), by inhibiting or promoting chemotaxis of cells involved in the inflammatory process, inhibiting or promoting cell extravasation, or by stimulating or suppressing production of other factors which more directly inhibit or promote an inflammatory response. Proteins exhibiting such activities can be used to treat inflammatory conditions including chronic or acute conditions), including without limitation intimation associated with infection (such as septic shock, sepsis or systemic inflammatory response syndrome (SIRS)), ischemia-reperfusion injury, endotoxin lethality, arthritis, complement-mediated hyperacute rejection, nephritis, cytokine or chemokine- induced lung injury, inflammatory bowel disease, Crohn's disease or resulting from over production of cytokines such as TNF or IL-1. Proteins of the invention may also be useful to treat anaphylaxis and hypersensitivity to an antigenic substance or material.
LEUKEMIAS
Leukemias and related disorders may be treated or prevented by administration of a therapeutic that promotes or inhibits function of the polynucleotides and/or polypeptides of the invention. Such leukemias and related disorders include but are not limited to acute leukemia, acute lymphocytic leukemia, acute myelocytic leukemia, myeloblastic, promyelocytic, myelomonocytic, monocytic, erythroleukemia, chronic leukemia, chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia (for a review of such disorders, see Fishman et al., 1985, Medicine, 2d Ed., J.B. Lippincott Co., Philadelphia).
PHARMACEUTICAL FORMULATIONS AND ROUTES OF ADMINISTRATION
A protein of the present invention (from whatever source derived, including without limitation from recombinant and non-recombinant sources) may be administered to a patient in need, by itself, or in pharmaceutical compositions where it is mixed with suitable carriers or excipient(s) at doses to treat or ameliorate a variety of disorders. Such a composition may also contain (in addition to protein and a carrier) diluents, fillers, salts, buffers, stabilizers, solubilizers, and other materials well known in the art. The term "pharmaceutically acceptable" means a non- toxic material that does not interfere with the effectiveness of the biological activity of the active ingredient(s). The characteristics of the carrier will depend on the route of administration. The pharmaceutical composition of the invention may also contain cytokines, lymphokines, or other hematopoietic factors such as compositions belonging to the interleukin and tumor necrosis factor families, thrombopoietin, stem cell factor, and erythropoietin. The pharmaceutical composition may further contain other agents which either enhance the activity of the protein or compliment its activity or use in treatment. Such additional factors and/or agents may be included in the pharmaceutical composition to produce a synergistic effect with protein of the invention, or to minimize side effects. Conversely, protein of the present invention may be included in formulations of the particular cytokine, lymphokine, other hematopoietic factor, thrombolytic or anti-thrombotic factor, or anti-inflammatory agent to minimize side effects of the cytokine, lymphokine, other hematopoietic factor, thrombolytic or anti-thrombotic factor, or anti-inflammatory agent. A protein of the present invention may be active in multimers (e.g., heterodimers or homodimers) or complexes with itself or other proteins. As a result, pharmaceutical compositions of the invention may comprise a protein of the invention in such multimeric or complexed form.
Techniques for formulation and administration of the compounds of the instant application may be found in "Remington's Pharmaceutical Sciences," Mack Publishing Co., Easton, PA, latest edition. A therapeutically effective dose further refers to that amount of the compound sufficient to result in amelioration of symptoms, e.g., treatment, healing, prevention or amelioration of the relevant medical condition, or an increase in rate of treatment, healing, prevention or amelioration of such conditions. When applied to an individual active ingredient, administered alone, a therapeutically effective dose refers to that ingredient alone. When applied to a combination, a therapeutically effective dose refers to combined amounts of the active ingredients that result in the therapeutic effect, whether administered in combination, serially or simultaneously.
In practicing the method of treatment or use of the present invention, a therapeutically effective amount of protein of the present invention is administered to a mammal having a condition to be treated. Protein of the present invention may be administered in accordance with the method of the invention either alone or in combination with other therapies such as treatments employing cytokines, lymphokines or other hematopoietic factors. When co-administered with one or more cytokines, lymphokines or other hematopoietic factors, protein of the present invention may be administered either simultaneously with the cytokine(s), lymphokine(s), other hematopoietic factor(s), thrombolytic or anti-thrombotic factors, or sequentially. If administered sequentially, the attending physician will decide on the appropriate sequence of administering protein of the present invention in combination with cytokine(s), lymphokine(s), other hematopoietic factor(s), thrombolytic or anti-thrombotic factors. ROUTES OF ADMINISTRATION
Suitable routes of administration may, for example, include oral, rectal, transmucosal, or intestinal administration; parenteral delivery, including intramuscular, subcutaneous, intramedullary injections, as well as intrathecal, direct intraventricular, intravenous, intraperitoneal, intranasal, or intraocular injections. Administration of protein of the present invention used in the pharmaceutical composition or to practice the method of the present invention can be carried out in a variety of conventional ways, such as oral ingestion, inhalation, topical application or cutaneous, subcutaneous, intraperitoneal, parenteral or intravenous injection. Intravenous administration to the patient is prefeπed.
Alternately, one may administer the compound in a local rather than systemic manner, for example, via injection of the compound directly into a arthritic joints or in fibrotic tissue, often in a depot or sustained release formulation. In order to prevent the scarring process frequently occurring as complication of glaucoma surgery, the compounds may be administered topically, for example, as eye drops. Furthermore, one may administer the drug in a targeted drug delivery system, for example, in a liposome coated with a specific antibody, targeting, for example, arthritic or fibrotic tissue. The liposomes will be targeted to and taken up selectively by the afflicted tissue.
COMPOSITIONS/FORMULATIONS Pharmaceutical compositions for use in accordance with the present invention thus may be formulated in a conventional manner using one or more physiologically acceptable carriers comprising excipients and auxiliaries which facilitate processing of the active compounds into preparations which can be used pharmaceutically. These pharmaceutical compositions may be manufactured in a manner that is itself known, e.g., by means of conventional mixing, dissolving, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping or lyophilizing processes. Proper formulation is dependent upon the route of administration chosen. When a therapeutically effective amount of protein of the present invention is administered orally, protein of the present invention will be in the form of a tablet, capsule, powder, solution or elixir. When administered in tablet form, the pharmaceutical composition of the invention may additionally contain a solid carrier such as a gelatin or an adjuvant. The tablet, capsule, and powder contain from about 5 to 95% protein of the present invention, and preferably from about 25 to 90% protein of the present invention. When administered in liquid form, a liquid carrier such as water, petroleum, oils of animal or plant origin such as peanut oil, mineral oil, soybean oil, or sesame oil, or synthetic oils may be added. The liquid form of the pharmaceutical composition may further contain physiological saline solution, dextrose or other saccharide solution, or glycols such as ethylene glycol, propylene glycol or polyethylene glycol. When administered in liquid form, the pharmaceutical composition contains from about 0.5 to 90% by weight of protein of the present invention, and preferably from about 1 to 50% protein of the present invention.
When a therapeutically effective amount of protein of the present invention is administered by intravenous, cutaneous or subcutaneous injection, protein of the present invention will be in the form of a pyrogen-free, parenterally acceptable aqueous solution. The preparation of such parenterally acceptable protein solutions, having due regard to pH, isotonicity, stability, and the like, is within the skill in the art. A preferred pharmaceutical composition for intravenous, cutaneous, or subcutaneous injection should contain, in addition to protein of the present invention, an isotonic vehicle such as Sodium Chloride Injection, Ringer's Injection, Dextrose Injection, Dextrose and Sodium Chloride Injection, Lactated Ringer's Injection, or other vehicle as known in the art. The pharmaceutical composition of the present invention may also contain stabilizers, preservatives, buffers, antioxidants, or other additives known to those of skill in the art. For injection, the agents of the invention may be formulated in aqueous solutions, preferably in physiologically compatible buffers such as Hanks's solution, Ringer's solution, or physiological saline buffer. For transmucosal administration, penetrants appropriate to the baπier to be permeated are used in the formulation. Such penetrants are generally known in the art.
For oral administration, the compounds can be formulated readily by combining the active compounds with pharmaceutically acceptable carriers well known in the art. Such earners enable the compounds of the invention to be formulated as tablets, pills, dragees, capsules, liquids, gels, syrups, slurries, suspensions and the like, for oral ingestion by a patient to be treated.
Pharmaceutical preparations for oral use can be obtained solid excipient, optionally grinding a resulting mixture, and processing the mixture of granules, after adding suitable auxiliaries, if desired, to obtain tablets or dragee cores. Suitable excipients are, in particular, fillers such as sugars, including lactose, sucrose, mannitol, or sorbitol; cellulose preparations such as, for example, maize starch, wheat starch, rice starch, potato starch, gelatin, gum tragacanth, methyl cellulose, hydroxypropylmethyl-cellulose, sodium carboxymethylcellulose, and/or polyvinylpyrrolidone (PVP). If desired, disintegrating agents may be added, such as the cross- linked polyvinyl pyrrolidone, agar, or alginic acid or a salt thereof such as sodium alginate. Dragee cores are provided with suitable coatings. For this puφose, concentrated sugar solutions may be used, which may optionally contain gum arabic, talc, polyvinyl pyπolidone, carbopol gel, polyethylene glycol, and/or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures. Dyestuffs or pigments may be added to the tablets or dragee coatings for identification or to characterize different combinations of active compound doses.
Pharmaceutical preparations which can be used orally include push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a plasticizer, such as glycerol or sorbitol. The push-fit capsules can contain the active ingredients in admixture with filler such as lactose, binders such as starches, and/or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, the active compounds may be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycols. In addition, stabilizers may be added. All formulations for oral administration should be in dosages suitable for such administration. For buccal administration, the compositions may take the form of tablets or lozenges formulated in conventional manner.
For administration by inhalation, the compounds for use according to the present invention are conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebuliser, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of a pressurized aerosol the dosage unit may be determined by providing a valve to deliver a metered amount. Capsules and cartridges of, e.g., gelatin for use in an inhaler or insufflator may be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch. The compounds may be formulated for parenteral administration by injection, e.g., by bolus injection or continuous infusion. Formulations for injection may be presented in unit dosage form, e.g., in ampoules or in multi-dose containers, with an added preservative. The compositions may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilizing and/or dispersing agents.
Pharmaceutical formulations for parenteral administration include aqueous solutions of the active compounds in water-soluble form. Additionally, suspensions of the active compounds may be prepared as appropriate oily injection suspensions. Suitable lipophilic solvents or vehicles include fatty oils such as sesame oil, or synthetic fatty acid esters, such as ethyl oleate or triglycerides, or liposomes. Aqueous injection suspensions may contain substances which increase the viscosity of the suspension, such as sodium carboxymethyl cellulose, sorbitol, or dextran. Optionally, the suspension may also contain suitable stabilizers or agents which increase the solubility of the compounds to allow for the preparation of highly concentrated solutions.
Alternatively, the active ingredient may be in powder form for constitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use.
The compounds may also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter or other glycerides. In addition to the formulations described previously, the compounds may also be formulated as a depot preparation. Such long acting formulations may be administered by implantation (for example subcutaneously or intramuscularly) or by intramuscular injection. Thus, for example, the compounds may be formulated with suitable polymeric or hydrophobic materials (for example as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt.
A pharmaceutical carrier for the hydrophobic compounds of the invention is a cosolvent system comprising benzyl alcohol, a nonpolar surfactant, a water-miscible organic polymer, and an aqueous phase. The cosolvent system may be the VPD co-solvent system. VPD is a solution of 3% w/v benzyl alcohol, 8% w/v of the nonpolar surfactant polysorbate 80, and 65% w/v polyethylene glycol 300, made up to volume in absolute ethanol. The VPD co-solvent system (VPD:5W) consists of VPD diluted 1 :1 with a 5% dextrose in water solution. This co-solvent system dissolves hydrophobic compounds well, and itself produces low toxicity upon systemic administration. Naturally, the proportions of a co-solvent system may be varied considerably without destroying its solubility and toxicity characteristics. Furthermore, the identity of the co-solvent components may be varied: for example, other low -toxicity nonpolar surfactants may be used instead of polysorbate 80; the fraction size of polyethylene glycol may be varied; other biocompatible polymers may replace polyethylene glycol, e.g. polyvinyl pyrrolidone; and other sugars or polysaccharides may substitute for dextrose. Alternatively, other delivery systems for hydrophobic pharmaceutical compounds may be employed. Liposomes and emulsions are well known examples of delivery vehicles or carriers for hydrophobic drugs. Certain organic solvents such as dimethylsulfoxide also may be employed, although usually at the cost of greater toxicity. Additionally, the compounds may be delivered using a sustained-release system, such as semipermeable matrices of solid hydrophobic polymers containing the therapeutic agent. Various sustained-release materials have been established and are well known by those skilled in the art. Sustained-release capsules may, depending on their chemical nature, release the compounds for a few weeks up to over 100 days. Depending on the chemical nature and the biological stability of the therapeutic reagent, additional strategies for protein stabilization may be employed.
The pharmaceutical compositions also may comprise suitable solid or gel phase carriers or excipients. Examples of such carriers or excipients include but are not limited to calcium carbonate, calcium phosphate, various sugars, starches, cellulose derivatives, gelatin, and polymers such as polyethylene glycols. Many of the proteinase inhibiting compounds of the invention may be provided as salts with pharmaceutically compatible counterions. Such pharmaceutically acceptable base addition salts are those salts which retain the biological effectiveness and properties of the free acids and which are obtained by reaction with inorganic or organic bases such as sodium hydroxide, magnesium hydroxide, ammonia, trialkylamine, dialkylamine, monoalkylamine, dibasic amino acids, sodium acetate, potassium benzoate, triethanol amine and the like.
The pharmaceutical composition of the invention may be in the form of a complex of the protein(s) of present invention along with protein or peptide antigens. The protein and/or peptide antigen will deliver a stimulatory signal to both B and T lymphocytes. B lymphocytes will respond to antigen through their surface immunoglobulin receptor. T lymphocytes will respond to antigen through the T cell receptor (TCR) following presentation of the antigen by MHC proteins. MHC and structurally related proteins including those encoded by class I and class II MHC genes on host cells will serve to present the peptide antigen(s) to T lymphocytes. The antigen components could also be supplied as purified MHC-peptide complexes alone or with co-stimulatory molecules that can directly signal T cells. Alternatively antibodies able to bind surface immunoglobulin and other molecules on B cells as well as antibodies able to bind the TCR and other molecules on T cells can be combined with the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be in the form of a liposome in which protein of the present invention is combined, in addition to other pharmaceutically acceptable carriers, with amphipathic agents such as lipids which exist in aggregated form as micelles, insoluble monolayers, liquid crystals, or lamellar layers in aqueous solution. Suitable lipids for liposomal formulation include, without limitation, monoglycerides, diglycerides, sulfatides, lysolecithin, phospholipids, saponin, bile acids, and the like. Preparation of such liposomal formulations is within the level of skill in the art, as disclosed, for example, in U.S. Pat. Nos. 4,235,871; 4,501,728; 4,837,028; and 4,737,323, all of which are incoφorated herein by reference.
The amount of protein of the present invention in the pharmaceutical composition of the present invention will depend upon the nature and severity of the condition being treated, and on the nature of prior treatments which the patient has undergone. Ultimately, the attending physician will decide the amount of protein of the present invention with which to treat each individual patient. Initially, the attending physician will administer low doses of protein of the present invention and observe the patient's response. Larger doses of protein of the present invention may be administered until the optimal therapeutic effect is obtained for the patient, and at that point the dosage is not increased further. It is contemplated that the various pharmaceutical compositions used to practice the method of the present invention should contain about 0.01 ?g to about 100 mg (preferably about 0.1 ?g to about 10 mg, more preferably about 0.1 ?g to about 1 mg) of protein of the present invention per kg body weight. For compositions of the present invention which are useful for bone, cartilage, tendon or ligament regeneration, the therapeutic method includes administering the composition topically, systematically, or locally as an implant or device. When administered, the therapeutic composition for use in this invention is, of course, in a pyrogen-free, physiologically acceptable form. Further, the composition may desirably be encapsulated or injected in a viscous form for delivery to the site of bone, cartilage or tissue damage. Topical administration may be suitable for wound healing and tissue repair. Therapeutically useful agents other than a protein of the invention which may also optionally be included in the composition as described above, may alternatively or additionally, be administered simultaneously or sequentially with the composition in the methods of the invention. Preferably for bone and/or cartilage formation, the composition would include a matrix capable of delivering the protein-containing composition to the site of bone and/or cartilage damage, providing a structure for the developing bone and cartilage and optimally capable of being resorbed into the body. Such matrices may be formed of materials presently in use for other implanted medical applications.
The choice of matrix material is based on biocompatibility, biodegradability, mechanical properties, cosmetic appearance and interface properties. The particular application of the compositions will define the appropriate formulation. Potential matrices for the compositions may be biodegradable and chemically defined calcium sulfate, tricalciumphosphate, hydroxyapatite, polylactic acid, polyglycolic acid and polyanhydrides. Other potential materials are biodegradable and biologically well-defined, such as bone or dermal collagen. Further matrices are comprised of pure proteins or extracellular matrix components. Other potential matrices are nonbiodegradable and chemically defined, such as sintered hydroxyapatite, bioglass, aluminates, or other ceramics. Matrices may be comprised of combinations of any of the above mentioned types of material, such as polylactic acid and hydroxyapatite or collagen and tricalciumphosphate. The bioceramics may be altered in composition, such as in calcium-aluminate-phosphate and processing to alter pore size, particle size, particle shape, and biodegradability. Presently prefeπed is a 50:50 (mole weight) copolymer of lactic acid and glycolic acid in the form of porous particles having diameters ranging from 150 to 800 microns. In some applications, it will be useful to utilize a sequestering agent, such as carboxymethyl cellulose or autologous blood clot, to prevent the protein compositions from disassociating from the matrix.
A preferred family of sequestering agents is cellulosic materials such as alkylcelluloses (including hydroxyalkylcelluloses), including methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropyl-methylcellulose, and carboxymethylcellulose, the most prefeπed being cationic salts of carboxymethylcellulose (CMC). Other prefeπed sequestering agents include hyaluronic acid, sodium alginate, poly(ethylene glycol), polyoxyethylene oxide, carboxyvinyl polymer and poly(vinyl alcohol). The amount of sequestering agent useful herein is 0.5-20 wt %, preferably 1-10 wt % based on total formulation weight, which represents the amount necessary to prevent desorbtion of the protein from the polymer matrix and to provide appropriate handling of the composition, yet not so much that the progenitor cells are prevented from infiltrating the matrix, thereby providing the protein the opportunity to assist the osteogenic activity of the progenitor cells. In further compositions, proteins of the invention may be combined with other agents beneficial to the treatment of the bone and/or cartilage defect, wound, or tissue in question. These agents include various growth factors such as epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factors (TGF-3 and TGF-2), and insulin-like growth factor (IGF).
The therapeutic compositions are also presently valuable for veterinary applications. Particularly domestic animals and thoroughbred horses, in addition to humans, are desired patients for such treatment with proteins of the present invention. The dosage regimen of a protein- containing pharmaceutical composition to be used in tissue regeneration will be determined by the attending physician considering various factors which modify the action of the proteins, e.g., amount of tissue weight desired to be formed, the site of damage, the condition of the damaged tissue, the size of a wound, type of damaged tissue (e.g., bone), the patient's age, sex, and diet, the severity of any infection, time of administration and other clinical factors. The dosage may vary with the type of matrix used in the reconstitution and with inclusion of other proteins in the pharmaceutical composition. For example, the addition of other known growth factors, such as IGF I (insulin like growth factor I), to the final composition, may also effect the dosage. Progress can be monitored by periodic assessment of tissue/bone growth and/or repair, for example, X-rays, histomoφhometric determinations and tetracycline labeling. Polynucleotides of the present invention can also be used for gene therapy. Such polynucleotides can be introduced either in vivo or ex vivo into cells for expression in a mammalian subject. Polynucleotides of the invention may also be administered by other known methods for introduction of nucleic acid into a cell or organism (including, without limitation, in the form of viral vectors or naked DNA). Cells may also be cultured ex vivo in the presence of proteins of the present invention in order to proliferate or to produce a desired effect on or activity in such cells. Treated cells can then be introduced in vivo for therapeutic puφoses.
EFFECTIVE DOSAGE Pharmaceutical compositions suitable for use in the present invention include compositions wherein the active ingredients are contained in an effective amount to achieve its intended puφose. More specifically, a therapeutically effective amount means an amount effective to prevent development of or to alleviate the existing symptoms of the subject being treated. Determination of the effective amounts is well within the capability of those skilled in the art, especially in light of the detailed disclosure provided herein. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays. For example, a dose can be formulated in animal models to achieve a circulating concentration range that includes the IC50 as determined in cell culture (i.e., the concentration of the test compound which achieves a half-maximal inhibition of the C-proteinase activity). Such information can be used to more accurately determine useful doses in humans. A therapeutically effective dose refers to that amount of the compound that results in amelioration of symptoms or a prolongation of survival in a patient. Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio between LD50 and ED50. Compounds which exhibit high therapeutic indices are prefeπed. The data obtained from these cell culture assays and animal studies can be used in formulating a range of dosage for use in human. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. The exact formulation, route of administration and dosage can be chosen by the individual physician in view of the patient's condition. See, e.g., Fingl et al., 1975, in "The Pharmacological Basis of Therapeutics", Ch. 1 p.l.Dosage amount and interval may be adjusted individually to provide plasma levels of the active moiety which are sufficient to maintain the C-proteinase inhibiting effects, or minimal effective concentration (MEC). The MEC will vary for each compound but can be estimated from in vitro data; for example, the concentration necessary to achieve 50-90% inhibition of the C-proteinase using the assays described herein. Dosages necessary to achieve the MEC will depend on individual characteristics and route of administration. However, HPLC assays or bioassays can be used to determine plasma concentrations.
Dosage intervals can also be determined using MEC value. Compounds should be administered using a regimen which maintains plasma levels above the MEC for 10-90% of the time, preferably between 30-90% and most preferably between 50-90%.In cases of local administration or selective uptake, the effective local concentration of the drug may not be related to plasma concentration.
The amount of composition administered will, of course, be dependent on the subject being treated, on the subject's weight, the severity of the affliction, the manner of administration and the judgment of the prescribing physician.
PACKAGING The compositions may, if desired, be presented in a pack or dispenser device which may contain one or more unit dosage forms containing the active ingredient. The pack may, for example, comprise metal or plastic foil, such as a blister pack. The pack or dispenser device may be accompanied by instructions for administration. Compositions comprising a compound of the invention formulated in a compatible pharmaceutical carrier may also be prepared, placed in an appropriate container, and labeled for treatment of an indicated condition.
ANTIBODIES
Another aspect of the invention is an antibody that specifically binds the polypeptide of the invention. Such antibodies can be either monoclonal or polyclonal antibodies, as well fragments thereof and humanized forms or fully human forms, such as those produced in transgenic animals. The invention further provides a hybridoma that produces an antibody according to the invention. Antibodies of the invention are useful for detection and/or purification of the polypeptides of the invention.
Protein of the invention may also be used to immunize animals to obtain polyclonal and monoclonal antibodies which specifically react with the protein. Such antibodies may be obtained using either the entire protein or fragments thereof as an immunogen. The peptide immunogens additionally may contain a cysteine residue at the carboxyl terminus, and are conjugated to a hapten such as keyhole limpet hemocyanin (KLH). Methods for synthesizing such peptides are known in the art, for example, as in R. P. Merrifield, J. Amer. Chem. Soc. 85, 2149-2154 (1963); J. L. Krstenansky, et al., FEBS Lett. 211, 10 (1987). Monoclonal antibodies binding to the protein of the invention may be useful diagnostic agents for the immunodetection of the protein. Neutralizing monoclonal antibodies binding to the protein may also be useful therapeutics for both conditions associated with the protein and also in the treatment of some forms of cancer where abnormal expression of the protein is involved. In the case of cancerous cells or leukemic cells, neutralizing monoclonal antibodies against the protein may be useful in detecting and preventing the metastatic spread of the cancerous cells, which may be mediated by the protein. In general, techniques for preparing polyclonal and monoclonal antibodies as well as hybridomas capable of producing the desired antibody are well known in the art (Campbell, A.M., Monoclonal Antibodies Technology: Laboratory Techniques in Biochemistry and Molecular Biology, Elsevier Science Publishers, Amsterdam, The Netherlands (1984); St. Groth et al., J. Immunol. 35:1-21 (1990); Kohler and Milstein, Nature 256:495-497 (1975)), the trioma technique, the human B-cell hybridoma technique (Kozbor et al., Immunology Today 4:72 (1983); Cole et al., in Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc. (1985), pp. 77-96). Any animal (mouse, rabbit, etc.) which is known to produce antibodies can be immunized with a peptide or polypeptide of the invention. Methods for immunization are well known in the art. Such methods include subcutaneous or intraperitoneal injection of the polypeptide. One skilled in the art will recognize that the amount of the protein encoded by the ORF of the present invention used for immunization will vary based on the animal which is immunized, the antigenicity of the peptide and the site of injection. The protein that is used as an immunogen may be modified or administered in an adjuvant in order to increase the protein's antigenicity. Methods of increasing the antigenicity of a protein are well known in the art and include, but are not limited to, coupling the antigen with a heterologous protein (such as globulin or ?-galactosidase) or through the inclusion of an adjuvant during immunization. For monoclonal antibodies, spleen cells from the immunized animals are removed, fused with myeloma cells, such as SP2/0-Agl4 myeloma cells, and allowed to become monoclonal antibody producing hybridoma cells. Any one of a number of methods well known in the art can be used to identify the hybridoma cell which produces an antibody with the desired characteristics. These include screening the hybridomas with an ELISA assay, western blot analysis, or radioimmunoassay (Lutz et al., Exp. Cell Research. 175:109-124 (1988)). Hybridomas secreting the desired antibodies are cloned and the class and subclass is determined using procedures known in the art (Campbell, A.M., Monoclonal Antibody Technology: Laboratory Techniques in Biochemistry and Molecular Biology, Elsevier Science Publishers, Amsterdam, The Netherlands (1984)). Techniques described for the production of single chain antibodies (U.S. Patent 4,946,778) can be adapted to produce single chain antibodies to proteins of the present invention.
For polyclonal antibodies, antibody containing antiserum is isolated from the immunized animal and is screened for the presence of antibodies with the desired specificity using one of the above-described procedures. The present invention further provides the above-described antibodies in delectably labeled form. Antibodies can be delectably labeled through the use of radioisotopes, affinity labels (such as biotin, avidin, etc.), enzymatic labels (such as horseradish peroxidase, alkaline phosphatase, etc.) fluorescent labels (such as FITC or rhodamine, etc.), paramagnetic atoms, etc. Procedures for accomplishing such labeling are well-known in the art, for example, see (Sternberger, L.A. et al., J. Histochem. Cytochem. 18:315 (1970); Bayer, E.A. et al., Meth. Enzym. 62:308 (1979); Engval, E. et al., Immunol. 109:129 (1972); Goding, J.W. J. Immunol. Meth. 13:215 (1976)). The labeled antibodies of the present invention can be used for in vitro, in vivo, and in situ assays to identify cells or tissues in which a fragment of the polypeptide of interest is expressed. The antibodies may also be used directly in therapies or other diagnostics. The present invention further provides the above-described antibodies immobilized on a solid support. Examples of such solid supports include plastics such as polycarbonate, complex carbohydrates such as agarose and sepharose, acrylic resins and such as polyacrylamide and latex beads. Techniques for coupling antibodies to such solid supports are well known in the art (Weir, D.M. et al., "Handbook of Experimental Immunology" 4th Ed., Blackwell Scientific Publications, Oxford, England, Chapter 10 (1986); Jacoby, W.D. et al., Meth. Enzym. 34 Academic Press, N.Y. (1974)). The immobilized antibodies of the present invention can be used for in vitro, in vivo, and in situ assays as well as for immuno-affinity purification of the proteins of the present invention.
HUMAN ANTIBODIES
Fully human antibodies relate to antibody molecules in which essentially the entire sequences of both the light chain and the heavy chain, including the CDRs, arise from human genes. Such antibodies are termed "human antibodies", or "fully human antibodies" herein. Human monoclonal antibodies can be prepared by the trioma technique; the human B-cell hybridoma technique (see Kozbor, et al., 1983 Immunol Today 4: 72) and the EBV hybridoma technique to produce human monoclonal antibodies (see Cole, et al., 1985 In: MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R. Liss, Inc., pp. 77-96). Human monoclonal antibodies may be utilized in the practice of the present invention and may be produced by using human hybridomas (see Cote, et al., 1983. Proc Natl Acad Sci USA 80: 2026-2030) or by transforming human B-cells with Epstein Ban Virus in vitro (see Cole, et al., 1985 In: MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R. Liss, Inc., pp. 77-96). In addition, human antibodies can also be produced using additional techniques, including phage display libraries (Hoogenboom and Winter, J. Mol. Biol.. 227:381 (1991); Marks et al., J. Mol. Biol., 222:581 (1991)). Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, for example, in U.S. Patent Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in Marks et al. (Bio/Technology JO, 779-783 (1992)); Lonberg et al. (Nature 368 856-859 (1994)); Morrison ( Nature 368, 812-13 (1994)); Fishwild et al.f Nature Biotechnology 14. 845-51 (1996)); Neuberger (Nature Biotechnology 14. 826 (1996)); and Lonberg and Huszar (Intern. Rev. Immunol. 13 65-93 (1995)). Human antibodies may additionally be produced using transgenic nonhuman animals which are modified so as to produce fully human antibodies rather than the animal's endogenous antibodies in response to challenge by an antigen. (See PCT publication WO94/02602). The endogenous genes encoding the heavy and light immunoglobulin chains in the nonhuman host have been incapacitated, and active loci encoding human heavy and light chain immunoglobulins are inserted into the host's genome. The human genes are incoφorated, for example, using yeast artificial chromosomes containing the requisite human DNA segments. An animal which provides all the desired modifications is then obtained as progeny by crossbreeding intermediate transgenic animals containing fewer than the full complement of the modifications. The prefeπed embodiment of such a nonhuman animal is a mouse, and is termed the Xenomouse™ as disclosed in PCT publications WO 96/33735 and WO 96/34096. This animal produces B cells which secrete fully human immunoglobulins. The antibodies can be obtained directly from the animal after immunization with an immunogen of interest, as, for example, a preparation of a polyclonal antibody, or alternatively from immortalized B cells derived from the animal, such as hybridomas producing monoclonal antibodies. Additionally, the genes encoding the immunoglobulins with human variable regions can be recovered and expressed to obtain the antibodies directly, or can be further modified to obtain analogs of antibodies such as, for example, single chain Fv molecules. An example of a method of producing a nonhuman host, exemplified as a mouse, lacking expression of an endogenous immunoglobulin heavy chain is disclosed in U.S. Patent No. 5,939,598. It can be obtained by a method including deleting the J segment genes from at least one endogenous heavy chain locus in an embryonic stem cell to prevent reaπangement of the locus and to prevent formation of a transcript of a reaπanged immunoglobulin heavy chain locus, the deletion being effected by a targeting vector containing a gene encoding a selectable marker; and producing from the embryonic stem cell a transgenic mouse whose somatic and germ cells contain the gene encoding the selectable marker.
A method for producing an antibody of interest, such as a human antibody, is disclosed in U.S. Patent No. 5,916,771. It includes introducing an expression vector that contains a nucleotide sequence encoding a heavy chain into one mammalian host cell in culture, introducing an expression vector containing a nucleotide sequence encoding a light chain into another mammalian host cell, and fusing the two cells to form a hybrid cell. The hybrid cell expresses an antibody containing the heavy chain and the light chain. In a further improvement on this procedure, a method for identifying a clinically relevant epitope on an immunogen, and a coπelative method for selecting an antibody that binds immunospecifically to the relevant epitope with high affinity, are disclosed in PCT publication WO 99/53049.
FAB FRAGMENTS AND SINGLE CHAIN ANTIBODIES
According to the invention, techniques can be adapted for the production of single-chain antibodies specific to an antigenic protein of the invention (see e.g., U.S. Patent No. 4,946,778). In addition, methods can be adapted for the construction of Fab expression libraries (see e.g., Huse, et al., 1989 Science 246: 1275-1281) to allow rapid and effective identification of monoclonal F_b fragments with the desired specificity for a protein or derivatives, fragments, analogs or homologs thereof. Antibody fragments that contain the idiotypes to a protein antigen may be produced by techniques known in the art including, but not limited to: (i) an F(ab')2 fragment produced by pepsin digestion of an antibody molecule; (ii) an Fab fragment generated by reducing the disulfide bridges of an F(ab')_ fragment; (iii) an Fab fragment generated by the treatment of the antibody molecule with papain and a reducing agent and (iv) Fv fragments.
BISPECIFIC ANTIBODIES
Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens. In the present case, one of the binding specificities is for an antigenic protein of the invention. The second binding target is any other antigen, and advantageously is a cell-surface protein or receptor or receptor subunit. Methods for making bispecific antibodies are known in the art. Traditionally, the recombinant production of bispecific antibodies is based on the co-expression of two immunoglobulin heavy-chain/light-chain pairs, where the two heavy chains have different specificities (Milstein and Cuello, Nature. 305:537-539 (1983)). Because of the random assortment of immunoglobulin heavy and light chains, these hybridomas (quadromas) produce a potential mixture often different antibody molecules, of which only one has the coπect bispecific structure. The purification of the coπect molecule is usually accomplished by affinity chromatography steps. Similar procedures are disclosed in WO 93/08829, published 13 May 1993, and in Traunecker et al, 1991 EMBO J., 10:3655-3659. Antibody variable domains with the desired binding specificities (antibody-antigen combining sites) can be fused to immunoglobulin constant domain sequences. The fusion preferably is with an immunoglobulin heavy-chain constant domain, comprising at least part of the hinge, CH2, and CH3 regions. It is preferred to have the first heavy-chain constant region (CHI) containing the site necessary for light-chain binding present in at least one of the fusions. DNAs encoding the immunoglobulin heavy-chain fusions and, if desired, the immunoglobulin light chain, are inserted into separate expression vectors, and are co-transfected into a suitable host organism. For further details of generating bispecific antibodies see, for example, Suresh et al., Methods in Enzymology. 121 :210 (1986).
According to another approach described in WO 96/27011, the interface between a pair of antibody molecules can be engineered to maximize the percentage of heterodimers which are recovered from recombinant cell culture. The prefened interface comprises at least a part of the CH3 region of an antibody constant domain. In this method, one or more small amino acid side chains from the interface of the first antibody molecule are replaced with larger side chains (e.g. tyrosine or tryptophan). Compensatory "cavities" of identical or similar size to the large side chain(s) are created on the interface of the second antibody molecule by replacing large amino acid side chains with smaller ones (e.g. alanine or threonine). This provides a mechanism for increasing the yield of the heterodimer over other unwanted end-products such as homodimers.
Bispecific antibodies can be prepared as full length antibodies or antibody fragments (e.g. F(ab')2 bispecific antibodies). Techniques for generating bispecific antibodies from antibody fragments have been described in the literature. For example, bispecific antibodies can be prepared using chemical linkage. Brennan et al., Science 229:81 (1985) describe a procedure wherein intact antibodies are proteolytically cleaved to generate F(ab')2 fragments. These fragments are reduced in the presence of the dithiol complexing agent sodium arsenite to stabilize vicinal dithiols and prevent intermolecular disulfide formation. The Fab' fragments generated are then converted to thionitrobenzoate (TNB) derivatives. One of the Fab'-TNB derivatives is then reconverted to the Fab'-thiol by reduction with mercaptoethylamine and is mixed with an equimolar amount of the other Fab'-TNB derivative to form the bispecific antibody. The bispecific antibodies produced can be used as agents for the selective immobilization of enzymes.
Additionally, Fab' fragments can be directly recovered from E. coli and chemically coupled to form bispecific antibodies. Shalaby et al., J. Exp. Med. 175:217-225 (1992) describe the production of a fully humanized bispecific antibody F(ab') molecule. Each Fab' fragment was separately secreted from E. coli and subjected to directed chemical coupling in vitro to form the bispecific antibody. The bispecific antibody thus formed was able to bind to cells overexpressing the ErbB2 receptor and normal human T cells, as well as trigger the lytic activity of human cytotoxic lymphocytes against human breast tumor targets. Various techniques for making and isolating bispecific antibody fragments directly from recombinant cell culture have also been described. For example, bispecific antibodies have been produced using leucine zippers. Kostelny et al., J. Immunol. 148(5): 1547- 1553 (1992). The leucine zipper peptides from the Fos and Jun proteins were linked to the Fab' portions of two different antibodies by gene fusion. The antibody homodimers were reduced at the hinge region to form monomers and then re-oxidized to form the antibody heterodimers. This method can also be utilized for the production of antibody homodimers. The "diabody" technology described by Hollinger et al., Proc. Natl. Acad. Sci. USA 90:6444-6448 (1993) has provided an alternative mechanism for making bispecific antibody fragments. The fragments comprise a heavy-chain variable domain (VH) connected to a light-chain variable domain (VL) by a linker which is too short to allow pairing between the two domains on the same chain. Accordingly, the VH and V domains of one fragment are forced to pair with the complementary VL and VH domains of another fragment, thereby forming two antigen-binding sites. Another strategy for making bispecific antibody fragments by the use of single-chain Fv (sFv) dimers has also been reported. See, Gruber et al., J. Immunol. 152:5368 (1994). Antibodies with more than two valencies are contemplated. For example, trispecific antibodies can be prepared. Tutt et al., J. Immunol. 147:60 (1991). Exemplary bispecific antibodies can bind to two different epitopes, at least one of which originates in the protein antigen of the invention. Alternatively, an anti-antigenic arm of an immunoglobulin molecule can be combined with an arm which binds to a triggering molecule on a leukocyte such as a T-cell receptor molecule (e.g. CD2, CD3, CD28, or B7), or Fc receptors for IgG (Fc R), such as Fc RI (CD64), Fc RII (CD32) and Fc RIII (CD 16) so as to focus cellular defense mechanisms to the cell expressing the particular antigen. Bispecific antibodies can also be used to direct cytotoxic agents to cells which express a particular antigen. These antibodies possess an antigen-binding arm and an arm which binds a cytotoxic agent or a radionuclide chelator, such as EOTUBE, DPTA, DOTA, or TETA. Another bispecific antibody of interest binds the protein antigen described herein and further binds tissue factor (TF).
HETEROCONJUGATE ANTIBODIES
Heteroconjugate antibodies are also within the scope of the present invention. Heteroconjugate antibodies are composed of two covalently joined antibodies. Such antibodies have, for example, been proposed to target immune system cells to unwanted cells (U.S. Patent No. 4,676,980), and for treatment of HIV infection (WO 91/00360; WO 92/200373; EP 03089). It is contemplated that the antibodies can be prepared in vitro using known methods in synthetic protein chemistry, including those involving crosslinking agents. For example, immunotoxins can be constructed using a disulfide exchange reaction or by forming a thioether bond. Examples of suitable reagents for this puφose include iminothiolate and methyl-4-mercaptobutyrimidate and those disclosed, for example, in U.S. Patent No. 4,676,980.
EFFECTOR FUNCTION ENGINEERING
It can be desirable to modify the antibody of the invention with respect to effector function, so as to enhance, e.g., the effectiveness of the antibody in treating cancer. For example, cysteine residue(s) can be introduced into the Fc region, thereby allowing interchain disulfide bond formation in this region. The homodimeric antibody thus generated can have improved internalization capability and/or increased complement-mediated cell killing and antibody- dependent cellular cytotoxicity (ADCC). See Caron et al., J. Exp Med., 176: 1191-1195 (1992) and Shopes, J. Immunol., 148: 2918-2922 (1992). Homodimeric antibodies with enhanced antitumor activity can also be prepared using heterobifunctional cross-linkers as described in Wolff et al. Cancer Research, 53: 2560-2565 (1993). Alternatively, an antibody can be engineered that has dual Fc regions and can thereby have enhanced complement lysis and ADCC capabilities. See Stevenson et al., Anti-Cancer Drug Design, 3: 219-230 (1989).
IMMUNOCONJUGATES
The invention also pertains to immunoconjugates comprising an antibody conjugated to a cytotoxic agent such as a chemotherapeutic agent, toxin (e.g., an enzymatically active toxin of bacterial, fungal, plant, or animal origin, or fragments thereof), or a radioactive isotope (i.e., a radioconjugate). Chemotherapeutic agents useful in the generation of such immunoconjugates have been described above. Enzymatically active toxins and fragments thereof that can be used include diphtheria A chain, nonbinding active fragments of diphtheria toxin, exotoxin A chain (from Pseudomonas aeruginosa), ricin A chain, abrin A chain, modeccin A chain, alpha-sarcin, Aleurites fordii proteins, dianthin proteins, Phytolaca americana proteins (PAPI, PAPII, and PAP-S), momordica charantia inhibitor, curcin, crotin, sapaonaria officinalis inhibitor, gelonin, mitogellin, restrictocin, phenomycin, enomycin, and the tricothecenes. A variety of radionuclides are available for the production of radioconjugated antibodies. Examples include 212Bi, I31I, 131In, 90Y, and 186Re.
Conjugates of the antibody and cytotoxic agent are made using a variety of bifunctional protein-coupling agents such as N-succinimidyl-3-(2-pyridyldithiol) propionate (SPDP), iminothiolane (IT), bifunctional derivatives of imidoesters (such as dimethyl adipimidate HCL), active esters (such as disuccinimidyl suberate), aldehydes (such as glutareldehyde), bis-azido compounds (such as bis (p-azidobenzoyl) hexanediamine), bis-diazonium derivatives (such as bis- (p-diazoniumbenzoyl)-ethylenediamine), diisocyanates (such as tolyene 2,6-diisocyanate), and bis- active fluorine compounds (such as l,5-difluoro-2,4-dinitrobenzene). For example, a ricin immunotoxin can be prepared as described in Vitetta et al., Science, 238: 1098 (1987). Carbon-14- labeled l-isothiocyanatobenzyl-3-methyldiethylene triaminepentaacetic acid (MX-DTPA) is an exemplary chelating agent for conjugation of radionucleotide to the antibody. See W094/11026. In another embodiment, the antibody can be conjugated to a "receptor" (such streptavidin) for utilization in tumor pretargeting wherein the antibody-receptor conjugate is administered to the patient, followed by removal of unbound conjugate from the circulation using a clearing agent and then administration of a "ligand" (e.g., avidin) that is in turn conjugated to a cytotoxic agent.
. COMPUTER READABLE SEQUENCES In one application of this embodiment, a nucleotide sequence of the present invention can be recorded on computer readable media. As used herein, "computer readable media" refers to any medium which can be read and accessed directly by a computer. Such media include, but are not limited to: magnetic storage media, such as floppy discs, hard disc storage medium, and magnetic tape; optical storage media such as CD-ROM; electrical storage media such as RAM and ROM; and hybrids of these categories such as magnetic/optical storage media. A skilled artisan can readily appreciate how any of the presently known computer readable mediums can be used to create a manufacture comprising computer readable medium having recorded thereon a nucleotide sequence of the present invention. As used herein, "recorded" refers to a process for storing information on computer readable medium. A skilled artisan can readily adopt any of the presently known methods for recording information on computer readable medium to generate manufactures comprising the nucleotide sequence information of the present invention.
A variety of data storage structures are available to a skilled artisan for creating a computer readable medium having recorded thereon a nucleotide sequence of the present invention. The choice of the data storage structure will generally be based on the means chosen to access the stored information. In addition, a variety of data processor programs and formats can be used to store the nucleotide sequence information of the present invention on computer readable medium. The sequence information can be represented in a word processing text file, formatted in commercially-available software such as WordPerfect and Microsoft Word, or represented in the form of an ASCII file, stored in a database application, such as DB2, Sybase, Oracle, or the like. A skilled artisan can readily adapt any number of dataprocessor structuring formats (e.g. text file or database) in order to obtain computer readable medium having recorded thereon the nucleotide sequence information of the present invention. By providing the nucleotide sequence of SEQ ID NO: 1, 3, 5, 7, 26, 28, 33, 36, 38, 40, or 44 or a representative fragment thereof, or a nucleotide sequence at least 99.9% identical to SEQ ID NO: 1, 3, 5, 7, 26, 28, 33, 36, 38, 40, or 44 in computer readable form, a skilled artisan can routinely access the sequence information for a variety of puφoses. Computer software is publicly available which allows a skilled artisan to access sequence information provided in a computer readable medium. The examples which follow demonstrate how software which implements the BLAST (Altschul et al., J. Mol. Biol. 215:403-410 (1990)) and BLAZE (Brutlag et al., Comp. Chem. 17:203-207 (1993)) search algorithms on a Sybase system is used to identify open reading frames (ORFs) within a nucleic acid sequence. Such ORFs may be protein encoding fragments and may be useful in producing commercially important proteins such as enzymes used in fermentation reactions and in the production of commercially useful metabolites.
As used herein, "a computer-based system" refers to the hardware means, software means, and data storage means used to analyze the nucleotide sequence information of the present invention. The minimum hardware means of the computer-based systems of the present invention comprises a central processing unit (CPU), input means, output means, and data storage means. A skilled artisan can readily appreciate that any one of the cuπently available computer-based systems are suitable for use in the present invention. As stated above, the computer-based systems of the present invention comprise a data storage means having stored therein a nucleotide sequence of the present invention and the necessary hardware means and software means for supporting and implementing a search means. As used herein, "data storage means" refers to memory which can store nucleotide sequence information of the present invention, or a memory access means which can access manufactures having recorded thereon the nucleotide sequence information of the present invention. As used herein, "search means" refers to one or more programs which are implemented on the computer-based system to compare a target sequence or target structural motif with the sequence information stored within the data storage means. Search means are used to identify fragments or regions of a known sequence which match a particular target sequence or target motif. A variety of known algorithms are disclosed publicly and a variety of commercially available software for conducting search means are and can be used in the computer-based systems of the present invention. Examples of such software includes, but is not limited to, MacPattern (EMBL), BLASTN and BLASTA (NPOLYPEPTIDEIA). A skilled artisan can readily recognize that any one of the available algorithms or implementing software packages for conducting homology searches can be adapted for use in the present computer-based systems. As used herein, a "target sequence" can be any nucleic acid or amino acid sequence of six or more nucleotides or two or more amino acids. A skilled artisan can readily recognize that the longer a target sequence is, the less likely a target sequence will be present as a random occuπence in the database. The most prefeπed sequence length of a target sequence is from about 10 to 100 amino acids or from about 30 to 300 nucleotide residues. However, it is well recognized that searches for commercially important fragments, such as sequence fragments involved in gene expression and protein processing, may be of shorter length.
As used herein, "a target structural motif," or "target motif," refers to any rationally selected sequence or combination of sequences in which the sequence(s) are chosen based on a three- dimensional configuration which is formed upon the folding of the target motif. There are a variety of target motifs known in the art. Protein target motifs include, but are not limited to, enzyme active sites and signal sequences. Nucleic acid target motifs include, but are not limited to, promoter sequences, haiφin structures and inducible expression elements (protein binding sequences).
TRIPLEX HELIX FORMATION In addition, the fragments of the present invention, as broadly described, can be used to control gene expression through triple helix formation or antisense DNA or RNA, both of which methods are based on the binding of a polynucleotide sequence to DNA or RNA. Polynucleotides suitable for use in these methods are usually 20 to 40 bases in length and are designed to be complementary to a region of the gene involved in transcription (triple helix - see Lee et al., Nucl. Acids Res. 6:3073 (1979); Cooney et al., Science 15241:456 (1988); and Dervan et al., Science 251 :1360 (1991)) or to the mRNA itself (antisense - Olmno, J. Neurochem. 56:560 (1991); Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression, CRC Press, Boca Raton, FL (1988)). Triple helix- formation optimally results in a shut-off of RNA transcription from DNA, while antisense RNA hybridization blocks translation of an mRNA molecule into polypeptide. Both techniques have been demonstrated to be effective in model systems. Information contained in the sequences of the present invention is necessary for the design of an antisense or triple helix oligonucleotide.
DIAGNOSTIC ASSAYS AND KITS The present invention further provides methods to identify the presence or expression of one of the ORFs of the present invention, or homolog thereof, in a test sample, using a nucleic acid probe or antibodies of the present invention.
In general, methods for detecting a polynucleotide of the invention can comprise contacting a sample with a compound that binds to and forms a complex with the polynucleotide for a period sufficient to form the complex, and detecting the complex, so that if a complex is detected, a polynucleotide of the invention is detected in the sample. Such methods can also comprise contacting a sample under stringent hybridization conditions with nucleic acid primers that anneal to a polynucleotide of the invention under such conditions, and amplifying annealed polynucleotides, so that if a polynucleotide is amplified, a polynucleotide of the invention is detected in the sample.
In general, methods for detecting a polypeptide of the invention can comprise contacting a sample with a compound that binds to and forms a complex with the polypeptide for a period sufficient to form the complex, and detecting the complex, so that if a complex is detected, a polypeptide of the invention is detected in the sample.
In detail, such methods comprise incubating a test sample with one or more of the antibodies or one or more of nucleic acid probes of the present invention and assaying for binding of the nucleic acid probes or antibodies to components within the test sample. Conditions for incubating a nucleic acid probe or antibody with a test sample vary.
Incubation conditions depend on the format employed in the assay, the detection methods employed, and the type and nature of the nucleic acid probe or antibody used in the assay. One skilled in the art will recognize that any one of the commonly available hybridization, amplification or immunological assay formats can readily be adapted to employ the nucleic acid probes or antibodies of the present invention. Examples of such assays can be found in Chard, T., An Introduction to Radioimmunoassay and Related Techniques, Elsevier Science Publishers, Amsterdam, The Netherlands (1986); Bullock, G.R. et al., Techniques in Immunocytochemistry, Academic Press, Orlando, FL Vol. 1 (1982), Vol. 2 (1983), Vol. 3 (1985); Tijssen, P., Practice and Theory of immunoassays: Laboratory Techniques in Biochemistry and Molecular Biology, Elsevier Science Publishers, Amsterdam, The Netherlands (1985). The test samples of the present invention include cells, protein or membrane extracts of cells, or biological fluids such as sputum, blood, serum, plasma, or urine. The test sample used in the above-described method will vary based on the assay format, nature of the detection method and the tissues, cells or extracts used as the sample to be assayed. Methods for preparing protein extracts or membrane extracts of cells are well known in the art and can be readily be adapted in order to obtain a sample which is compatible with the system utilized.
In another embodiment of the present invention, kits are provided which contain the necessary reagents to carry out the assays of the present invention. Specifically, the invention provides a compartment kit to receive, in close confinement, one or more containers which comprises: (a) a first container comprising one of the probes or antibodies of the present invention; and (b) one or more other containers comprising one or more of the following: wash reagents, reagents capable of detecting presence of a bound probe or antibody.
In detail, a compartment kit includes any kit in which reagents are contained in separate containers. Such containers include small glass containers, plastic containers or strips of plastic or paper. Such containers allows one to efficiently transfer reagents from one compartment to another compartment such that the samples and reagents are not cross-contaminated, and the agents or solutions of each container can be added in a quantitative fashion from one compartment to another. Such containers will include a container which will accept the test sample, a container which contains the antibodies used in the assay, containers which contain wash reagents (such as phosphate buffered saline, Tris-buffers, etc.), and containers which contain the reagents used to detect the bound antibody or probe. Types of detection reagents include labeled nucleic acid probes, labeled secondary antibodies, or in the alternative, if the primary antibody is labeled, the enzymatic, or antibody binding reagents which are capable of reacting with the labeled antibody. One skilled in the art will readily recognize that the disclosed probes and antibodies of the present invention can be readily incoφorated into one of the established kit formats which are well known in the art.
SCREENING ASSAYS
Using the isolated proteins and polynucleotides of the invention, the present invention further provides methods of obtaining and identifying agents which bind to a protein encoded by the ORF from a nucleic acid with a sequence of SEQ ID NOS: l, 3, 5, 7, 9, 11-15, 26, 28, 33, 36, 38 40, or 44 to a specific domain of the polypeptide encoded by the nucleic acid, or to a nucleic acid with a sequence of SEQ ID NOS:l, 3, 5, 7, 9, 11-15, 26, 28, 33, 36, 38, 40, or 44. In detail, said method comprises the steps of:
(a) contacting an agent with an isolated protein encoded by an ORF of the present invention, or nucleic acid of the invention; and
(b) determining whether the agent binds to said protein or said nucleic acid.
In general, therefore, such methods for identifying compounds that bind to a polynucleotide of the invention can comprise contacting a compound with a polynucleotide of the invention for a time sufficient to form a polynucleotide/compound complex, and detecting the complex, so that if a polynucleotide/compound complex is detected, a compound that binds to a polynucleotide of the invention is identified.
Likewise, in general, therefore, such methods for identifying compounds that bind to a . polypeptide of the invention can comprise contacting a compound with a polypeptide of the invention for a time sufficient to form a polypeptide/compound complex, and detecting the complex, so that if a polypeptide/compound complex is detected, a compound that binds to a polynucleotide of the invention is identified.
Methods for identifying compounds that bind to a polypeptide of the invention can also comprise contacting a compound with a polypeptide of the invention in a cell for a time sufficient to form a polypeptide/compound complex, wherein the complex drives expression of a receptor gene sequence in the cell, and detecting the complex by detecting reporter gene sequence expression, so that if a polypeptide/compound complex is detected, a compound that binds a polypeptide of the invention is identified.
Compounds identified via such methods can include compounds which modulate the activity of a polypeptide of the invention (that is, increase or decrease its activity, relative to activity observed in the absence of the compound). Alternatively, compounds identified via such methods can include compounds which modulate the expression of a polynucleotide of the invention (that is, increase or decrease expression relative to expression levels observed in the absence of the compound). Compounds, such as compounds identified via the methods of the invention, can be tested using standard assays well known to those of skill in the art for their ability to modulate activity/expression. The agents screened in the above assay can be, but are not limited to, peptides, carbohydrates, vitamin derivatives, or other pharmaceutical agents. The agents can be selected and screened at random or rationally selected or designed using protein modeling techniques. For random screening, agents such as peptides, carbohydrates, pharmaceutical agents and the like are selected at random and are assayed for their ability to bind to the protein encoded, by the ORF of the present invention. Alternatively, agents may be rationally selected or designed. As used herein, an agent is said to be "rationally selected or designed" when the agent is chosen based on the configuration of the particular protein. For example, one skilled in the art can readily adapt cunently available procedures to generate peptides, pharmaceutical agents and the like capable of binding to a specific peptide sequence in order to generate rationally designed antipeptide peptides, for example see Hurby et al., Application of Synthetic Peptides: Antisense Peptides," In Synthetic Peptides, A User's Guide, W.H. Freeman, NY (1992), pp. 289-307, and Kaspczak et al., Biochemistry 28:9230-8 (1989), or pharmaceutical agents, or the like.
In addition to the foregoing, one class of agents of the present invention, as broadly described, can be used to control gene expression through binding to one of the ORFs or EMFs of the present invention. As described above, such agents can be randomly screened or rationally designed/selected. Targeting the ORF or EMF allows a skilled artisan to design sequence specific or element specific agents, modulating the expression of either a single ORF or multiple ORFs which rely on the same EMF for expression control. One class of DNA binding agents are agents which contain base residues which hybridize or form a triple helix formation by binding to DNA or RNA. Such agents can be based on the classic phosphodiester, ribonucleic acid backbone, or can be a variety of sulfhydryl or polymeric derivatives which have base attachment capacity.
Agents suitable for use in these methods usually contain 20 to 40 bases and are designed to be complementary to a region of the gene involved in transcription (triple helix - see Lee et al., Nucl. Acids Res. 6:3073 (1979); Cooney et al., Science 241 :456 (1988); and Dervan et al., Science 251 :1360 (1991)) or to the mRNA itself (antisense - Okano, J. Neurochem. 56:560 (1991); Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression, CRC Press, Boca Raton, FL (1988)). Triple helix- formation optimally results in a shut-off of RNA transcription from DNA, while antisense RNA hybridization blocks translation of an mRNA molecule into polypeptide. Both techniques have been demonstrated to be effective in model systems. Information contained in the sequences of the present invention is necessary for the design of an antisense or triple helix oligonucleotide and other DNA binding agents. Agents which bind to a protein encoded by one of the ORFs of the present invention can be used as a diagnostic agent, in the control of bacterial infection by modulating the activity of the protein encoded by the ORF. Agents which bind to a protein encoded by one of the ORFs of the present invention can be formulated using known techniques to generate a pharmaceutical composition.
USE OF NUCLEIC ACIDS AS PROBES
Another aspect of the subject invention is to provide for polypeptide-specific nucleic acid hybridization probes capable of hybridizing with naturally occurring nucleotide sequences. The hybridization probes of the subject invention may be derived from the nucleotide sequences of SEQ ID NOS:l, 3, 5, 7, 9, 1 1-15, 26, 28, 33, 36, 38, 40 or 44. Because the coπesponding gene is only expressed in a limited number of tissues, especially adult tissues, a hybridization probe derived from SEQ ID NOS:l, 3, 5, 7, 9, 11-15, 26, 28, 33, 36, 38, 40 or 44 can be used as an indicator of the presence of RNA of cell type of such a tissue in a sample. Any suitable hybridization technique can be employed, such as, for example, in situ hybridization. PCR as described US Patent Nos 4,683,195 and 4,965,188 provides additional uses for oligonucleotides based upon the nucleotide sequences. Such probes used in PCR may be of recombinant origin, may be chemically synthesized, or a mixture of both. The probe will comprise a discrete nucleotide sequence for the detection of identical sequences or a degenerate pool of possible sequences for identification of closely related genomic sequences.
Other means for producing specific hybridization probes for nucleic acids include the cloning of nucleic acid sequences into vectors for the production of mRNA probes. Such vectors are known in the art and are commercially available and may be used to synthesize RNA probes in vitro by means of the addition of the appropriate RNA polymerase as T7 or SP6 RNA polymerase and the appropriate radioactively labeled nucleotides. The nucleotide sequences may be used to construct hybridization probes for mapping their respective genomic sequences. The nucleotide sequence provided herein may be mapped to a chromosome or specific regions of a chromosome using well known genetic and/or chromosomal mapping techniques. These techniques include in situ hybridization, linkage analysis against known chromosomal markers, hybridization screening with libraries or flow-sorted chromosomal preparations specific to known chromosomes, and the like. The technique of fluorescent in situ hybridization of chromosome spreads has been described, among other places, in Verma et al (1988) Human Chromosomes: A Manual of Basic Techniques, Pergamon Press, New York NY.
Fluorescent in situ hybridization of chromosomal preparations and other physical chromosome mapping techniques may be coπelated with additional genetic map data. Examples of genetic map data can be found in the 1994 Genome Issue of Science (265: 198 If). Coπelation between the location of a nucleic acid on a physical chromosomal map and a specific disease (or predisposition to a specific disease) may help delimit the region of DNA associated with that genetic disease. The nucleotide sequences of the subject invention may be used to detect differences in gene sequences between normal, caπier or affected individuals. The nucleotide sequence may be used to produce purified polypeptides using well known methods of recombinant DNA technology. Among the many publications that teach methods for the expression of genes after they have been isolated is Goeddel (1990) Gene Expression Technology, Methods and Enzymology, Vol 185, Academic Press, San Diego. Polypeptides may be expressed in a variety of host cells, either prokaryotic or eukaryotic. Host cells may be from the same species from which a particular polypeptide nucleotide sequence was isolated or from a different species. Advantages of producing polypeptides by recombinant DNA technology include obtaining adequate amounts of the protein for purification and the availability of simplified purification procedures.
The present invention is illustrated in the following examples. Upon consideration of the present disclosure, one of skill in the art will appreciate that many other embodiments and variations may be made in the scope of the present invention. Accordingly, it is intended that the broader aspects of the present invention not be limited to the disclosure of the following examples.
EXAMPLES
EXAMPLE 1: Identification of Novel BPI-Like Polypeptide and Polynucleotide Sequences
Described herein is the cloning and characterization of novel BPIL polynucleotide sequences and polypeptide sequences encoded by the polynucleotide sequences. These sequences are refeπed to below as "BPIL196-1", "BPIL196-2", "BPIL232-1 ", "BPIL232-2", "BPIL232-3", "BPIL232-4", "BPIL325-1", "BPIL325-2" and "BPIL325-4". The novel sequences were obtained from cDNA libraries (CLONTECH Laboratories, Inc., Palo Alto, CA), prepared from various human tissues, including, but not limited to, adult bone maπow, adult brain, adult cerebellum, adult heart, adult kidney, adult lymph node, adult liver, adult lung, adult ovary, adult placenta, adult salivary gland, adult spleen, adult testis, adult trachea, bone maπow, fetal heart, fetal kidney, fetal liver, fetal liver-spleen, fetal spleen, fetal lung, fetal skin, fetal lymphocyte, fetal brain, fetal leukocyte and macrophage, as described in Bonaldo et al., Genome Res. 6:791-806 (1996), using standard PCR, Sequencing by Hybridization (SBH) sequence signature analysis and Sanger sequencing techniques. The inserts of the library were amplified with PCR using primers specific for vector sequences flanking the inserts. These samples were spotted onto nylon membranes and interrogated with oligonucleotide probes to give sequence signatures. The clones were clustered into groups of similar or identical sequences, and single representative clones were selected from each group for gel sequencing.
The 5' sequence of the amplified inserts was then deduced using the reverse M13 sequencing primer in a typical Sanger sequencing protocol. PCR products were purified and subjected to fluorescent dye terminator cycle sequencing. Single-pass gel sequencing was done using a 377 Applied Biosystems (ABI) sequencer. Among these inserts identified as novel sequences not previously obtained from these libraries, and not previously reported in public databases, were the inserts of clones BPIL196-1, BPIL196-2, BPIL232-1, BPIL232-2, BPIL232-3, BPIL232-4, BPIL325-1, BPIL325-2 BPIL325-3 and BPIL325-4.
EXAMPLE 2: Isolation and Sequence Characterization of BPIL196 Genes
A novel cDNA comprising a BPIL polynucleotide and polypeptide, refeπed to herein as BPIL196, was identified. The sequence obtained from clones containing partial coding sequences or non-coding sequences was used to obtain the entire coding region by using the RACE method, for example (Chenchik, et al., 1995, CLONTECHniques (X) 1 : 5-8; Barnes, 1994, Proc. Natl.
Acad. Sci. USA 91 : 2216-2220; and Cheng et al., Proc. Natl. Acad. Sci. USA 91: 5695-5699). The following oligonucleotides were designed based on the sequence obtained from partial clones that could amplify a reverse transcribed mRNA encoding the entire coding sequence:
Primary: BPIL196R3 5'-CGGTGCCCATCAGTGTGCGCACCTGATCT
(SEQ ID NO: 16) Nested: BPIL 196R4 5'-CACGTTGGAGGAGGCCACCGT (SEQ ID NO: 17)
Primary: BPIL196R7 5'-GCCAGGACCTCCACGAAGGGCTGCAGCCA
(SEQ ID NO: 18) Nested: BPIL196R8 5'-GGAGCATGGCCACAGGTGTGG (SEQ ID NO: 19)
Primary: BPIL196R9 5'-GACTTCCAGGGAAATGTAGTCACTGGTGA
(SEQ ID NO:20)
Nested: BPIL196R10 5'-CATGGAATAGCGGATCTGGGA (SEQ ID NO:21)
Database searches with both the polynucleotide sequences and the derived amino acid sequences identified homology with members of the bactericidal/permeability increasing factor family (BPI). The highest homology, which was about 59% similarity, existed with fragments of the human BPI precursor (Ace. No. AAA51841).
EXAMPLE 3: Isolation and Sequence Characterization of BPIL232 Genes
A novel cDNA comprising a BPI-like polynucleotide and polypeptide, refeπed to herein as BPIL232, was identified. The sequence obtained from clones containing partial coding sequences or non-coding sequences was used to obtain the entire coding region by using the RACE method, for example (Chenchik, et al., 1995, CLONTECHniques (X) 1: 5-8; Barnes, 1994, Proc. Natl. Acad. Sci. USA 91: 2216-2220; and Cheng et al., Proc. Natl. Acad. Sci. USA 91 : 5695-5699). The following oligonucleotides were designed based on the sequence obtained from partial clones that could amplify a reverse transcribed mRNA encoding the entire coding sequence:
Primary: BPIL232R1 5'-GAGACAAGGAGCAGACCAGTCTTTGTCCC
(SEQ ID NO:22) Nested: BPIL196R2 5'-CACTGGTACTAGCAACGAAGT (SEQ ID NO:23)
Primary: BPIL196R3 5'-GGAAACGATGGTTTCAACTGTGGAGTTCT
(SEQ ID NO:24) Nested: BPIL196R4 5'-CATGATGGAGGCAGGGATGTC (SEQ ID NO:25)
EXAMPLE 4: Isolation and Sequence Characterization of BPIL325 Genes A novel cDNA comprising a BPI-like polynucleotide and polypeptide, refeπed to herein as
BPIL325-1, was identified.
Database searches with both the polynucleotide sequences and the derived amino acid sequences identified homology with members of the rat ligand binding protein RY2G5 and the bactericidal/permeability increasing factor family (BPI). The highest homology, which was about 61% similarity, existed with fragments of the rat RY2G5 ligand binding protein (Ace. No. SI 7447). Additional homology, which was about 51% similarity, existed with fragments of the human BPI precursor (Ace. No. AAA51841).
BPIL 325-3 was generated in silico as follows. A stretch of genomic DNA (Accession # AL121756) with homology to the BPIL 325 cDNA was found in the public database. This genomic DNA originated from a human DNA sequence from clone RP4-726C3 on chromosome 20. The genomic sequence containing homology to BPIL325 was scanned with the exon prediction program GenScan v. 1.0 to generate BPIL325-3.
The sequence variant BPIL325-4 was obtained by rapid amplification of cDNA ends (RACE). Tonsil RNA (Biochain Institute) was used to create a Marathon cDNA library (Clontech). Marathon-ready cDNA was used as template in RACE with adaptor primer AP 1
(Clontech) and a gene-specific primer (5'-CTGGGAGCAGCAGCTGCGACGAGCC-3' Seq ID No: 178). This was followed by a nested RACE PCR with AP2 (Clontech) and another gene- specific primer 5 '-GGCATAACCCTCAGGGAACGTGAGG-3' (Seq ID No: 179). The detailed protocol for the generation of the library and the RACE are described in the respective manuals from Clontech. The resultant PCR products were cloned and sequenced.
EXAMPLE 5: Expression of the Members of the Novel BPIL Family
To study the role of BPIL polynucleotide, BPIL polypeotides were expressed. Human cDNA libraries were used as sources of expressed genes from tissues of interest (adult bone manow, adult brain, adult cerebellum, adult heart, adult kidney, adult lymph node, adult liver, adult lung, adult ovary, adult placenta, adult salivary gland, adult spleen, adult testis, adult trachea, bone marrow, fetal heart, fetal kidney, fetal liver, fetal liver-spleen, fetal spleen, fetal lung, fetal skin, fetal brain, fetal leukocyte and macrophage). Gene-specific primers were used to amplify various portions of the clones. Amplified products were separated on an agarose gel.
BPIL196-1 (SEQ ID NO:l) and BPIL196-2 (SEQ ID NO:3) were expressed in a limited set of human tissues. Of the human tissues tested, the BPIL 196 genes were expressed in adult bone maπow, adult cerebellum, adult liver, adult lung, adult salivary gland, adult trachea, fetal brain, fetal heart, fetal liver, fetal lung and fetal spleen.
BPIL232-1 (SEQ ID NO:5) and BPIL232-2 (SEQ ID NO:7) also were expressed in a limited set of human tissues. Of the human tissues tested, the BPIL232 genes were expressed in fetal skin.
BPIL232-3 (SEQ ID NO:26), BPIL232-5 (SEQ ID NO:38), BPIL232-4 (SEQ ID NO:28) and BPIL232-6 (SEQ ID NO:40) also were expressed in a limited set of human tissues. Of the human tissues tested, these BPIL232 genes were expressed in fetal skin and fetal lymphocytes.
BPIL325-1 (SEQ ID NO:9) and BPIL325-2 (SEQ ID NO:33) also were expressed in a limited set of human tissues. Of the human tissues tested, these BPIL325 genes were expressed in adult trachea.
EXAMPLE 6: Expression of BPILX in mammalian COS-7 cells
Gene specific primers coπesponding to the translational start region and the carboxy- terminal region, excluding the stop codon of the BPIL196 sequence were used (5'- TGCTCTAGAGCTCTGGTAGAAGAGTCCACTGG-3'(Seq ID No: 180) and 5'- TTTGAATTCATGGCTTGGGCAAGTAGGCTGGGC-3' Seq ID No: 181). These primers generated a fragment of DNA coπesponding to the entire coding region of the BPIL 196 gene, flanked by EcoRl and Xbal sites. The PCR product was digested accordingly to generate overhang ends that were ligated into the EcoRl and Xbal sites of pcDNA3.1/myc-His(+)A (Invifrogen). The resultant mammalian expression plasmid (BPIL196mychis) allows for expression of the BPIL196 coding sequence fused in- frame with the myc-6His epitope at the carboxy terminus. A similar strategy was used to generate a fragment of DNA containing the BPIL-232 coding region flanked by Kpnl and Xbal sites with gene specific primers (5'- TTTGGTACCATGTGTACAAAGACAATCCCAGTC-3 ' (Seq ID No: 182)and 5 '-
TGCTCTAGAAGGGGCTGACTTCCCCCTCCACTG-3' Seq ID No: 183). This generated BPIL232mychis allowing for the expression of the BPIL232 coding sequence fused in- frame with the myc-6His epitope at the carboxy terminus. BPIL325 was cloned into the mammalian expression vector pMT2-myc/His. Gene-specific primers (5'-
ATAGTCGACACCATGCTGCGGATCCTGTGCCTGGCA-3' (Seq ID No: 184) and 5'- TATCTCGAGGCCCAGCTTCAAGTCCAGCAT-3 ' Seq ID No: 185) flanked by a Sail site at the 5'end and a Xhol site at the 3' end were used to amplify the entire coding region. The PCR product was digested accordingly to generate overhang ends that were located into the Sail and Xhol of pMT2-myc/His.
BPI was also expressed as a control. The BPI cDNA was idenified in sequence database originating from bone maπow cDNA library (Clonetech) Gene specifc primers ( 5'
ATAGTCGACAGGATGAGAGAGAACATGGCCAGG-3'; SEQ ID NO: 186) AND 5'- TATCTCGAGTATTTTGGTCATTACTGGCAG-3'; SEQ ID NO: 187) flanked by a Sail site at the 5' end and a Xhol site at the 3' end were used to subclone the first 199 amino acids of the BPI into the mammalian expression vector pMTl-myc/His. The mammalian expression vectors were transfected into COS-7 cells. Briefly, the cells in
10 ml of medium were incubated with 16 ul of Fugene-6 and 4 ug of DNA for 12 h. The medium was then replaced with serum-free DMEM and incubated for an additional 48 h prior to harvesting. After the conditioned medium was collected from transfected COS cells, cells were washed twice with PBS and then scrapped from plates. Upon centrifugation, the cells were resuspended in PBS containing 0.5 ug/ml leupeptin, 0.7 ug/ml pepstatin, and 0.2 ug/ml aprotinin. After a brief sonication, the cytosolic fraction was separated from the insoluble membrane fraction by centrifugation. Purification of proteins from the cytosolic and from the media took place at 4 C in the presence of 100 ul of Ni-NTA resin (Qiagen). The resin was washed twice with 50 mM Tris- HC1 (pH 7.5), 300 mM NaCl, and 5 mM imidazole. The elution of the protein took place by increasing the imidazole concentration to 250 mM.
To determine the cellular localization of the BPIL proteins, Western blot analysis was performed on the protein isolated from cytosolic, membrane, and medium fractions using an anti- myc antibody. BPIL 196-2 was detected primarily in the medium (60%), but some protein was also detected in the membrane fraction (40%). The predicted molecular mass of the BPIL 196-2 protein is 48.5 kDa. However, membrane (55 kDa) and secreted fractions (60 kDa) displayed slower electrophoretic mobility than the predicted encoded protein, suggesting that BPIL 196-2 contains post-translational modifications.
BPIL232-3 protein was distributed equally between the medium and the membrane fractions. The protein also displayed slower electrophoretic mobility (65 kDa) than the predicted molecular mass of 55 kDa.
BPIL325-4 protein was found exclusively in the membrane fraction. The protein displayed a slower electrophoretic mobility (60 kDa) than its predicted size of 49 kDa.
The control BPI protein was found to accumulate primarily in the pellet (70%) with the rest localizing to the medium (30%) as a soluble protein.
EXAMPLE 7: Chromosomal localization of BPIL196
To determine the chromosomal localization of BPIL196, gene specific PCR primers (5'- GATATCCAGTGGACTCTTCTACC-3' (SEQ ID NO: 188) and 5'- CAGGTCTATACAGCCTGGAGG-3 ' SEQ ID NO: 189) were screened against the NIGMS human rodent somatic cell hybrid mapping panel #2 and the Stanford G3 Human/Hamster Radiation Hybrid panel (Research Genetics). PCR amplification of the 315 nt product was performed using the following conditions; an initial denaturation at 94 C, followed by 40 cycles of 30 s at 94 C, 1 min at 52 C and 1 min at 72 C, followed by an extension of 10 mn at 72 C. All products were separated by 3% agarose gel electrophoresis and visualized via ethidium bromide staining. Linkage analysis and subsequent chromosomal localization were obtained through use of the Stanford Human Genome Center RH server (https://www-shgc.stanford.edu/RH/). The BPIL196 gene was mapped to a region at or near 20ql 1, 28 cR from marker SHGC-15969 with a LOD score of 8.44. This region is in very close proximity to the BPI locus (20ql l-ql2).
EXAMPLE 8: Tissue Specific Expression of BPIL Nucleic Acids
BPIL-196-2, BPIL-325-4, BPIL-232-3, BPI and G3PDH specific primers were designed to perform expression analysis using a normalized, first-strand cDNA panel of human immune tissues (Clontech). The tissues represented were spleen, lymph node, thymus, tonsil, bone maπow, fetal liver, colon and peripheral blood leukocyte. This cDNA panel was used as a template for PCR analysis, and expression levels were compared to that of the housekeeping gene glycerol 3 phosphate dehydrogenase (G3PDH). The PCR conditions were as follow: 94 C for 2.5 min (1 cycle); 94 C for 30 s, 56 C for 30 s, and 72 C for 2 min (30 cycles), and 72 C for 10 min (1 cycle). Amplified products were separated on a 2 % agarose gel. The expression of BPIL-196-2 and BPIL-325-4 was found in tonsil only. The expression of BPIL-232-3 was not found in any of the tissues analyzed. The expression of BPI control (procedure described in Example 6) was present most abundantly in bone maπow with lesser expression in peripheral blood leukocyte and fetal liver. As expected, G3PDH was expressed in all tissues. Interestingly, the expression of our BPIL molecules did not overlap with that of BPI in this panel of cDNA tissues.
Figure imgf000157_0001
EXAMPLE 9: Expression of BPIL Nucleic Acids in Tonsil Tissue mRNA from pooled healthy tonsil tissues and from pooled diseased tonsils (Biochain Institute) were analyzed to determine whether BPIL 196-2 and BPIL325-4 were expressed differentially in diseased and normal tonsil tissues. The mRNA was reversed transcribed using Superscript reverse transcriptase (Gibco) according to the manufacturer's recommendations. The expression of BPIL325-4, BPIL196 and actin (5'-CCTAAGGCCAACCGTGAAAAG-3' (SEQ ID NO: 200)and 5'-TCTTCATGGTGCTAGGAGCCA-3' (SEQ ID NO: 201)) was monitored by PCR amplification using gene specific primers. PCRs were terminated after 17, 25,30 and 35 cycles to avoid saturating conditions. The relative levels of expression were compared between normal and disease tissues. The levels of actin were identical between normal and diseased tissues under nonsaturating conditions (17 cycles). However, the levels of BPIL325-4 were approximately 3 fold higher in the diseased tonsils under nonsaturating conditions (30 cycles). No differences were detected for BPIL-196-2. The selected primers recognize all the isoforms for each gene.
EXAMPLE 10: Proliferation Assay
Recently, BPI was found to be a novel inhibitor of angiogenesis via the induction of apoptosis in vascular endothelial cells (Blood (2000) 96:176-181). Tumors are dependent on angiogenesis for outgrowth and metastasis. Therefore, inhibitors of angiogenesis are important pharmacologic candidates for antiangiogenic therapy in the clinic. The potential angiogenic effects from the BPIL molecules of this invention were investigated in vitro with the use of an endothelial cell proliferation assay with cultured HUVECs.
In our human umbilical endothelial cell (HUVECs) proliferation assay we coated 96-well culture plates with 1 mg/ml fibronectin (sigma) for 2 h at r.t.. The cells were seeded at a concentration of 4000 cells per well in a volume of 50 ul. The cells were allowed to adhere for 3 h at 37°C at 5% C02, and subsequently, 50 ul culture medium with or without the BPI or BPIL196-2 or BPIL232-3 was added. The cells were cultured for another 48 h. We determined in triplicate the relative amounts of live cells using a celltiter 96 AQ proliferation assay (PROMEGA). Briefly, the reagent was added directly to the cells (20 ul of reagent/ 100 ul of culture medium) and incubated for 1 h. The quantity of formazan product measured at 490 nm is directly proportional to the number of living cells in culture. Preliminary results showed that when we compared the relative growth of cells treated with BPI, BPIL196 and BPIL232 at a 1 μg/ml concentration and non-treated cells we found a 26.3% growth inhibition in the cells treated with BPIL196 but not in the other treated cells. The proliferation assay was tested with other cell types including the monocytic cell line U-937, the monkey kidney cell line COS-7and the Chinese Hamster Ovary cell line CHO. All of these cell lines were inhibited by BPI, BPIL 196-2 and BPIL232-3 at a concentration of 1 μg/ml.
Figure imgf000158_0001
Figure imgf000159_0001
Figure imgf000159_0002
Figure imgf000159_0003
Figure imgf000159_0004
EXAMPLE 11: Antimicrobial assay
Bacteria were grown overnight and diluted to an OD 6o of 0.2. The bacteria were added to 96-well microtiter plates at a volume of 150 μl /well. BPI, BPIL196 or BPIL232 were added at different dosages (highest dose at 2 ug/ml) in a final volume of 50 μl. The bacteria were incubated at 37 C and growth was monitored in a microplate reader with a 590 nm filter. Readings were taken every 2 hours for the first 8 hours with a final reading after 24 hours. The microbes grown were the gram-negative rod Escherichia coli, the gram positive rod Bacillus subtillis, the gram- positive cocci Streptococcus porcinus and Staphylococcus epidermidis, the gram-negative cocci Moraxella catanhalis and the yeast Candida albicans. Lower concentrations did not display growth inhibition. Duplicate wells were used to calculate growth inhibition relative to the control wells. EXAMPLE 12: Determination of BPILX Crystal Structure
Crystallization is used to verify the predicted three-dimensional structure of the BPILX molecules of this invention using methods known in the art, e.g., as described by Vigers et al., Nature. 386, pp. 190-194 (1997). Recombinant BPILX and BPILX receptor are incubated under conditions which promote binding. The ligand-receptor complex is then purified and crystallized.
Crystals consisting of BPILX alone, or ligand-receptor complex, are grown by methods known in the art. See, e.g., Jensen et al., J. Immunol., 15, pp. 5277-86 (2000). For example, hanging-drop diffusion against a salt solution such as ammonium sulphate solution, an ammonium nitrate solution or an ammonium chloride solution may be used to form BPILX crystals. The resulting crystals are diffracted in a beam of x-rays to determine their quality. Heavy atoms derivatives are created and compared to the native crystal. The crystals are cryoprotected and diffracted to determine the diffraction pattern, the unit cell dimensions and symmetry. Molecular replacement is used to determine the final three-dimensional structure.
EXAMPLE 13: Three-Dimensional Structure of BPILX
The GeneAtlas™ software package (Molecular Simulations Inc. (MSI), San Diego, CA) was used to predict the three-dimensional structure models of BPILX Models were generated by (1) PSI-Blast which is the multiple alignment sequence profile-based searching developed by Altschuel et al, (Nucl. Acids Res. 25: 3389-3408, 1997). (2) High Throughput Modeling (MSI) which is an automated sequence and structure searching procedure, and (3) SeqFold which is a fold recognition method described by Fischer and Eisenberg (J. Mol. Biol. 209: 779-791, 1998). This analysis was carried out in part by comparing the BPILX amino acid sequence with x-ray crystal three-dimensional structures of BPIC as templates.
The protein database coordinates BPILX, Hyl structural models are shown in Table 49-59 below. These structural coordinates were calculated based on the three-dimensional structure of IL-1 Ra. The protein database coordinate output file in this format provided the atom number, atom name, amino acid side chain, amino acid number, the X, Y and Z coordinates, occupancy (Occup) and the B-factor associated with each atom. The "Atom Name" refers to the element whose coordinates are measured. The "Amino Acid Side Chain" refers to the name of the amino acid, and the "Amino Acid Number" refers to the position in the IL-1 HI amino acid sequence in the structural model. The "X, Y and Z coordinates" refer to the atomic position measured in Angstroms. An occupancy of 1 indicates the position is fully occupied. The "B-factor refers to the thermal factor that measures movement of the atom around the atomic center. The term "ISG" indicates the name of the structure file given by the MSI program, and the last column indicates the row number. The MSI GeneAtlas™ program used the known NMR structure of IL-1 Ra as a template to derive the coordinates which can be used to generate the electron density map of IL-1 Hyl. Those of skill in the art will understand the structural coordinates set out in the tables are not without standard eπor, and a standard eπor +5 Angstroms may be incoφorated.
EXAMPLE 14: Determination of Important Residues by Site-Directed Mutagenesis
Site-directed mutagenesis is carried out to confirm the location of specific amino acids within the BPILX polypeptide sequence such as those residues predicted to interact with those receptors or ligands to which BPILX residues bind, and other residues predicted to be important to biological function. The mutants are designed based on the predicted three-dimensional structure or on the crystal structure.
Mutants are produced via site-directed mutagenesis which is performed on BPILX cDNA constructs using any method known in the art. For example, uracil-enrichment of single-stranded DNA may be used as described by Kunkel et al (Proc. Natl. Acad. Sci. U.S.A., 82; 488-492, 1985). Mutagenesis primers are designed based on the (+) coding orientation, and mutagenesis is caπied out with a commercially available mutagenesis kit such as the Muta-Gene kit (Biorad) or the Transformer™ Site-Directed Mutagenesis kit (Clontech) according to the manufacturer's instructions.
The mutants generated will have non-conservative substitutions of amino acids predicted to be important for BPILX function or BPILX binding. In addition, mutants will have amino acid insertions and/or deletions within functional domains and a single mutant may contain more than one change within the amino acid sequence.
The resulting mutants of cDNAs are sequenced, and recombinant BPILX mutants are purified and analyzed in functional assays. Both mutants which knock out function and those that increase function are desirable. In addition, these mutants can be crystallized (as described in Example 12) to determine if a change in the amino acid sequence alters the three-dimensional structure of BPILX. Mutants lacking BPILX activity, including binding activity are useful in screening for compounds which bind to the wild type BPILX polypeptide but do not interact with the BPILX mutants and thus identifying modulators specific for the active site.
INDEX OF ATOMIC COORDINATES TABLES
TABLE 49 Atomic Coordinates of BPIL 196- 1 Molecular Model
TABLE 50 Atomic Coordinates of BPIL 196- 2 Molecular Model
TABLE 51 Atomic Coordinates of BPIL 232- 1 Molecular Model
TABLE 52 Atomic Coordinates of BPIL 232- 2 Molecular Model
TABLE 53 Atomic Coordinates of BPIL 232- 3 Molecular Model
TABLE 54 Atomic Coordinates of BPIL 232- 4 Molecular Model
TABLE 55 Atomic Coordinates of BPIL 232- 5 Molecular Model
TABLE 56 Atomic Coordinates of BPIL 325- 2 Molecular Model
TABLE 57 Atomic Coordinates of BPIL 325- 3 Molecular Model
TABLE 58 Atomic Coordinates of BPIL 325- 4 Molecular Model
TABLE 59 Atomic Coordinates of BPIL 232- 6 Molecular Model
TABLE 49 Atomic Coordinates of BPIL 196-1 Molecular Model
ATOM 1 N SER 1 98, .980 11, .229 16. .184 1. .00 24. .09 1SG 2
ATOM 2 CA SER 1 97. .903 11. .865 15. .391 1. .00 24. ,09 1SG 3
ATOM 3 CB SER 1 96. .620 11. .999 16. .228 1. .00 24. ,09 1SG 4
ATOM 4 OG SER 1 96, .121 10, .713 16. .565 1. .00 24. .09 1SG 5
ATOM 5 C SER 1 98, .305 13, .221 14. .921 1. .00 24. .09 1SG 6
ATOM 6 O SER 1 99. .479 13. .584 14. .962 1. .00 24. ,09 1SG 7
ATOM 7 N THR 2 97, .321 14, .007 14, .447 1. .00 26. .87 1SG 8
ATOM 8 CA THR 2 97, .623 15. .318 13. .960 1. .00 26. .87 1SG 9
ATOM 9 CB THR 2 96, .493 15. .959 13. .209 1. .00 26. .87 1SG 10
ATOM 10 OG1 THR 2 96, .132 15, .164 12. .089 1, .00 26. .87 1SG 11
ATOM 11 CG2 THR 2 96, .941 17, .356 12. .746 1. .00 26. .87 1SG 12
ATOM 12 C THR 2 97. .917 16. .175 15. .143 1. .00 26. .87 1SG 13
ATOM 13 O THR 2 97 .299 16, .047 16, .199 1. .00 26. .87 1SG 14
ATOM 14 N PRO 3 98, .888 17, .028 14. .981 1. .00 31. .33 1SG 15
ATOM 15 CA PRO 3 99, .258 17. .930 16. .033 1. .00 31. .33 1SG 16
ATOM 16 CD PRO 3 99 .993 16, .758 14, .080 1, .00 31. .33 1SG 17
ATOM 17 CB PRO 3 100, .692 18, .376 15, .734 1. .00 31. .33 1SG 18
ATOM 18 CG PRO 3 100, .929 17. .962 14. .270 1. .00 31. .33 1SG 19
ATOM 19 C PRO 3 98 .291 19. .061 16. .136 1. .00 31, .33 1SG 20
ATOM 20 O PRO 3 97, .759 19, .494 15, .116 1. .00 31. .33 1SG 21
ATOM 21 N GLY 4 98, .034 19. .529 17. .370 1, .00 35. .37 1SG 22
ATOM 22 CA GLY 4 97 .164 20, .641 17. .619 1. .00 35, .37 1SG 23
ATOM 23 C GLY 4 97, .811 21. .905 17. .154 1. .00 35, .37 1SG 24
ATOM 24 O GLY 4 97, .130 22, .819 16. .694 1. .00 35. .37 1SG 25
ATOM 25 N THR 5 99 .145 22, .018 17. .330 1. .00 40, .88 1SG 26
ATOM 26 CA THR 5 99 .814 23, .223 16. .934 1, .00 40, .88 1SG 27
ATOM 27 CB THR 5 100, .217 24 , .090 18. .087 1. .00 40. .88 1SG 28
ATOM 28 OG1 THR 5 100 .708 25, .336 17. .614 1. .00 40. .88 1SG 29
ATOM 29 CG2 THR 5 101 .302 23. .359 18, .896 1, .00 40. .88 1SG 30
ATOM 30 C THR 5 101, .057 22, .853 16 , .202 1. .00 40. .88 1SG 31
ATOM 31 o THR 5 101 .688 21, .839 16 .496 1 .00 40. .88 1SG 32
ATOM 32 N VAL 6 101 .437 23, .678 15, .208 1. .00 45, .25 1SG 33
ATOM 33 CA VAL 6 102, .635 23, .383 14 , .489 1. .00 45. .25 1SG 34
ATOM 34 CB VAL 6 102 .385 22 .924 13, .083 1 .00 45, .25 1SG 35
ATOM 35 CGI VAL 6 102 .013 24, .143 12, .222 1. .00 45, .25 1SG 36
ATOM 36 CG2 VAL 6 103, .615 22, .144 12 , .599 1, .00 45, .25 1SG 37
ATOM 37 C VAL 6 103 .429 24, .643 14, .423 1 .00 45, .25 1SG 38
ATOM 38 o VAL 6 102, .876 25, .734 14 , .289 1. .00 45, .25 1SG 39
ATOM 39 N VAL 7 104, .763 24. .528 14. .547 1, .00 47, .14 1SG 40
ATOM 40 CA VAL 7 105 .552 25. .711 14, .443 1 .00 47, .14 1SG 41
ATOM 41 CB VAL 7 106, .389 26. .007 15, .657 1. .00 47. .14 1SG 42
ATOM 42 CGI VAL 7 107, .552 25. .006 15. .741 1, .00 47. .14 1SG 43
ATOM 43 CG2 VAL 7 106 .835 27. .475 15. .589 1. .00 47, .14 1SG 44
ATOM 44 C VAL 7 106 .454 25, .511 13. .273 1, .00 47, .14 1SG 45
ATOM 45 O VAL 7 107, .057 24 , .451 13. .107 1. .00 47. .14 1SG 46
ATOM 46 N ARG 8 106 .535 26 .523 12. .393 1. .00 47, .71 1SG 47
ATOM 47 CA ARG 8 107, .412 26, .384 11. .276 1. .00 47, .71 1SG 48
ATOM 48 CB ARG 8 106, .681 26, .405 9. .922 1. .00 47. .71 1SG 49
ATOM 49 CG ARG 8 105 .887 25, .119 9. .677 1. .00 47, .71 1SG 50
ATOM 50 CD ARG 8 105, .008 25, .144 8. .426 1, .00 47. .71 1SG 51
ATOM 51 NE ARG 8 105, .829 25. .676 7. .302 1. .00 47. .71 1SG 52
ATOM 52 CZ ARG 8 105 .580 25. .266 6. .024 1, .00 47. .71 1SG 53
ATOM 53 NH1 ARG 8 104, .654 24. .292 5. .786 1. .00 47. .71 1SG 54
ATOM 54 NH2 ARG 8 106. .250 25. .836 4. .982 1. .00 47. .71 1SG 55 ATOM 55 c ARG 8 108..380 27..514 11..333 1..00 47..71 1SG 56
ATOM 56 o ARG 8 108. .000 28. .682 11, .385 1. .00 47. .71 1SG 57
ATOM 57 N LEU 9 109. .679 27. .175 11, .332 1. .00 44. .86 1SG 58
ATOM 58 CA LEU 9 110. .691 28. .181 11, .423 1. .00 44. .86 1SG 59
ATOM 59 CB LEU 9 111. .867 27. .735 12. .309 1. .00 44. .86 1SG 60 TOM 60 CG LEU 9 112. .810 28. .866 12. .748 1. .00 44. .86 1SG 61
ATOM 61 CD2 LEU 9 114. .173 28. .324 13. .206 1. .00 44, .86 1SG 62
ATOM 62 CD1 LEU 9 112, .126 29, .748 13. .808 1. .00 44, .86 1SG 63
ATOM 63 C LEU 9 111, .204 28. .347 10. .026 1, .00 44. .86 1SG 64
ATOM 64 o LEU 9 111, .564 27. .370 9, .371 1. .00 44. .86 1SG 65
ATOM 65 N ASN 10 111. .229 29. .599 9. .530 1. .00 39. .68 1SG 66
ATOM 66 CA ASN 10 111. .643 29. .867 8. .181 1, .00 39. .68 1SG 67
ATOM 67 CB ASN 10 110. .926 31. .083 7, .561 1, .00 39. .68 1SG 68 TOM 68 CG ASN 10 Ill, .113 31. .061 6. .049 1. .00 39, .68 1SG 69
ATOM 69 ODl ASN 10 112 , .016 31. .691 5. .502 1. .00 39, .68 1SG 70
ATOM 70 ND2 ASN 10 110, .230 30. .300 5. .348 1. .00 39. .68 1SG 71
ATOM 71 C ASN 10 113 .120 30 .116 8. .153 1. .00 39 .68 1SG 72 TOM 72 O ASN 10 113, .780 30. .187 9. .188 1. .00 39. .68 1SG 73
ATOM 73 N LYS 11 113, .671 30, .247 6. .930 1, .00 34. .39 1SG 74
ATOM 74 CA LYS 11 115, .074 30, .454 6. .720 1, .00 34, .39 1SG 75
ATOM 75 CB LYS 11 115, .445 30, .568 5. .231 1. .00 34, .39 1SG 76
ATOM 76 CG LYS 11 116, .949 30, .707 4. .987 1, .00 34, .39 1SG 77
ATOM 77 CD LYS 11 117 .750 29, .463 5. .378 1, .00 34, .39 1SG 78
ATOM 78 CE LYS 11 117, .445 28, .236 4. .516 1, .00 34, .39 1SG 79 TOM 79 NZ LYS 11 118, .089 28, .374 3, .190 1, .00 34, .39 1SG 80
ATOM 80 C LYS 11 115, .458 31, .733 7. .385 1, .00 34, .39 1SG 81
ATOM 81 O LYS 11 116, .540 31. .842 7. .960 1, .00 34, .39 1SG 82
ATOM 82 N ALA 12 114, .571 32. .742 7. .330 1. .00 28 .15 1SG 83
ATOM 83 CA ALA 12 114 .876 34, .002 7. .939 1, .00 28 .15 1SG 84
ATOM 84 CB ALA 12 113, .734 35, .022 7. .807 1, .00 28, .15 1SG 85
ATOM 85 C ALA 12 115, .081 33, .747 9. .394 1, .00 28, .15 1SG 86
ATOM 86 o ALA 12 115, .977 34 , .314 10. .016 1. .00 28, .15 1SG 87
ATOM 87 N ALA 13 114 .235 32 .881 9. .976 1 .00 25 .99 1SG 88
ATOM 88 CA ALA 13 114 .331 32, .562 11, .368 1, .00 25 .99 1SG 89
ATOM 89 CB ALA 13 113, .204 31, .640 11, .833 1, .00 25 .99 1SG 90 TOM 90 C ALA 13 115, .619 31, .850 11, .639 1, .00 25, .99 1SG 91
ATOM 91 o ALA 13 116, .280 32 , .115 12 , .641 1, .00 25, .99 1SG 92
ATOM 92 N LEU 14 116 .007 30 .919 10, .746 1, .00 26 .07 1SG 93
ATOM 93 CA LEU 14 117, .188 30, .127 10, .949 1, .00 26, .07 1SG 94
ATOM 94 CB LEU 14 117, .403 29, .086 9, .837 1. .00 26, .07 1SG 95
ATOM 95 CG LEU 14 116, .291 28, .024 9, .763 1. .00 26, .07 1SG 96
ATOM 96 CD2 LEU 14 116, .062 27, .360 11, .134 1. .00 26, .07 1SG 97
ATOM 97 CD1 LEU 14 116, .558 27, .008 8, .640 1, .00 26, .07 1SG 98
ATOM 98 C LEU 14 118 .382 31, .025 10, .948 1, .00 26, .07 1SG 99
ATOM 99 O LEU 14 119, .281 30, .871 11, .773 1, .00 26, .07 1SG 100
ATOM 100 N SER 15 118, .410 32, .010 10, .032 1. .00 27, .87 1SG 101
ATOM 101 CA SER 15 119. .552 32. .869 9. .935 1. .00 27. .87 1SG 102
ATOM 102 CB SER 15 119 .397 33, .944 8. .847 1, .00 27. .87 1SG 103
ATOM 103 OG SER 15 119. .307 33, .333 7. .568 1, .00 27. .87 1SG 104
ATOM 104 C SER 15 119, .727 33, .570 11. .243 1. .00 27, .87 1SG 105
ATOM 105 o SER 15 120, .848 33. .758 11. .714 1. .00 27, .87 1SG 106
ATOM 106 N TYR 16 118, .608 33. .966 11. .870 1. .00 31. .62 1SG 107
ATOM 107 CA TYR 16 118, .651 34. .673 13, .116 1. .00 31. .62 1SG 108
ATOM 108 CB TYR 16 117, .245 35. .077 13, .591 1. .00 31. .62 1SG 109
ATOM 109 CG TYR 16 117, .385 35. .962 14. .779 1. .00 31, .62 1SG 110
ATOM 110 CD1 TYR 16 117. .664 35. .443 16. .021 1. .00 31, .62 1SG 111 TOM 111 CD2 TYR 16 117. .223 37. .321 14. .648 1. .00 31. .62 1SG 112 ATOM 112 CE1 TYR 16 117.788 36.272 17.111 1.00 31.62 1SG 113
ATOM 113 CE2 TYR 16 117. 345 38. 154 15. ,734 1. ,00 31. ,62 1SG 114
ATOM 114 CZ TYR 16 117. 630 37. ,629 16. .970 1. ,00 31. 62 1SG 115
ATOM 115 OH TYR 16 117. ,757 38. ,479 18. .089 1. ,00 31. 62 1SG 116
ATOM 116 C TYR 16 119. ,237 33. ,759 14. ,145 1. ,00 31. ,62 1SG 117
ATOM 117 o TYR 16 120. ,080 34. ,165 14. ,944 1. ,00 31. .62 1SG 118
ATOM 118 N VAL 17 118. ,810 32. ,482 14. .131 1. .00 34. .01 1SG 119
ATOM 119 CA VAL 17 119. ,250 31. ,516 15. ,094 1. .00 34. ,01 1SG 120 TOM 120 CB VAL 17 118. ,657 30. ,158 14. ,855 1. ,00 34. ,01 1SG 121
ATOM 121 CGI VAL 17 119. ,262 29. .172 15. .868 1. .00 34. .01 1SG 122
ATOM 122 CG2 VAL 17 117. ,125 30. .272 14. .929 1. .00 34. .01 1SG 123
ATOM 123 C VAL 17 120. ,733 31. .383 14. .978 1. .00 34. .01 1SG 124
ATOM 124 o VAL 17 121. .447 31. .307 15. .977 1. .00 34. .01 1SG 125
ATOM 125 N SER 18 121. .232 31. .355 13. .734 1. .00 36. .05 1SG 126
ATOM 126 CA SER 18 122. .632 31. .185 13. .494 1. .00 36. .05 1SG 127
ATOM 127 CB SER 18 122. .961 31. .193 11. .994 1. .00 36. .05 1SG 128
ATOM 128 OG SER 18 122. .147 30. .250 11. .316 1. .00 36, .05 1SG 129
ATOM 129 C SER 18 123. .363 32. .351 14 , .069 1. .00 36, .05 1SG 130
ATOM 130 o SER 18 124. .415 32, .193 14. .685 1. .00 36, .05 1SG 131
ATOM 131 N GLU 19 122. .807 33, .561 13. .881 1. .00 37, .82 1SG 132
ATOM 132 CA GLU 19 123. .478 34 , .757 14. .297 1. .00 37, .82 1SG 133
ATOM 133 CB GLU 19 122. .675 36, .025 13. .964 1. .00 37, .82 1SG 134
ATOM 134 CG GLU 19 122. .530 36, .283 12, .464 1, .00 37 .82 1SG 135
ATOM 135 CD GLU 19 121. .718 37. .558 12, .289 1. .00 37, .82 1SG 136
ATOM 136 OE1 GLU 19 121. .309 38. .143 13. .328 1. .00 37, .82 1SG 137
ATOM 137 OE2 GLU 19 121. .493 37. .962 11, .117 1, .00 37, .82 1SG 138
ATOM 138 C GLU 19 123. .670 34. .738 15, .776 1. .00 37, .82 1SG 139
ATOM 139 o GLU 19 124. .771 34. .993 16 , .263 1. .00 37. .82 1SG 140
ATOM 140 N ILE 20 122, .613 34, .429 16, .548 1. .00 39. .30 1SG 141
ATOM 141 CA ILE 20 122, .842 34, .450 17, .959 1, .00 39. .30 1SG 142
ATOM 142 CB ILE 20 121, .637 34, .395 18, .870 1. .00 39 .30 1SG 143
ATOM 143 CG2 ILE 20 120. .817 35, .668 18, .606 1. .00 39. .30 1SG 144
ATOM 144 CGI ILE 20 120, .819 33, .108 18, .731 1. .00 39. .30 1SG 145
ATOM 145 CD1 ILE 20 119, .984 33 .085 17, .463 1. .00 39 .30 1SG 146
ATOM 146 C ILE 20 123, .778 33, .350 18. .314 1, .00 39 .30 1SG 147
ATOM 147 o ILE 20 124, .630 33, .528 19, .173 1, .00 39 .30 1SG 148
ATOM 148 N GLY 21 123, .666 32 .174 17 .678 1, .00 39 .68 1SG 149
ATOM 149 CA GLY 21 124, .545 31, .107 18, .063 1, .00 39 .68 1SG 150
ATOM 150 C GLY 21 125, .968 31 .511 17, .824 1, .00 39 .68 1SG 151
ATOM 151 o GLY 21 126, .834 31 .312 18 .674 1, .00 39 .68 1SG 152
ATOM 152 N LYS 22 126 .233 32 .144 16, .670 1, .00 42 .16 1SG 153
ATOM 153 CA LYS 22 127 .563 32 .492 16 .263 1 .00 42 .16 1SG 154
ATOM 154 CB LYS 22 127, .546 33 .371 15 .002 1, .00 42 .16 1SG 155
ATOM 155 CG LYS 22 128 .926 33 .781 14 .495 1 .00 42 .16 1SG 156
ATOM 156 CD LYS 22 128 .889 34 .407 13 .098 1 .00 42 .16 1SG 157
ATOM 157 CE LYS 22 127, .996 35, .647 13 , .009 1. .00 42. .16 1SG 158
ATOM 158 NZ LYS 22 128. .013 36, .187 11, .631 1. .00 42. .16 1SG 159
ATOM 159 C LYS 22 128, .218 33, .318 17, .317 1, .00 42, .16 1SG 160
ATOM 160 o LYS 22 129, .362 33 .054 17, .685 1, .00 42, .16 1SG 161
ATOM 161 N ALA 23 127, .513 34, .333 17, .845 1, .00 44, .07 1SG 162
ATOM 162 CA ALA 23 128, .186 35, .188 18, .775 1, .00 44, .07 1SG 163 TOM 163 CB ALA 23 127, .331 36, .389 19, .231 1, .00 44, .07 1SG 164
ATOM 164 C ALA 23 128, .630 34, .385 19, .968 1, .00 44, .07 1SG 165
ATOM 165 o ALA 23 129, .795 34, .478 20, .349 1, .00 44, .07 1SG 166
ATOM 166 N PRO 24 127, .792 33, .580 20. .573 1, .00 46, .37 1SG 167
ATOM 167 CA PRO 24 128, .332 32 .774 21, .623 1, .00 46, .37 1SG 168
ATOM 168 CD PRO 24 126, .559 34 .143 21, .084 1, .00 46, .37 1SG 169 ATOM 169 CB PRO 24 127.,138 32.,173 22..370 1.00 46.37 1SG 170
ATOM 170 CG PRO 24 125. .927 32. 981 21. .864 1. 00 46. 37 1SG 171
ATOM 171 C PRO 24 129. .356 31. .785 21. ,180 1. 00 46. 37 1SG 172
ATOM 172 o PRO 24 130. .183 31. .400 22. .003 1. 00 46. 37 1SG 173
ATOM 173 N LEU 25 129. .312 31. .328 19. .916 1. 00 47. 79 1SG 174
ATOM 174 CA LEU 25 130. .320 30. .420 19. .450 1. 00 47. 79 1SG 175
ATOM 175 CB LEU 25 130. ,045 29. .799 18. .067 1. 00 47. 79 1SG 176
ATOM 176 CG LEU 25 129. .178 28. ,525 18. .103 1. .00 47. 79 1SG 177
ATOM 177 CD2 LEU 25 129. .072 27. .899 16. .704 1. 00 47. 79 1SG 178
ATOM 178 CD1 LEU 25 127. .809 28. .757 18. .752 1. .00 47. .79 1SG 179
ATOM 179 C LEU 25 131. .636 31. .121 19. .384 1. 00 47. 79 1SG 180
ATOM 180 o LEU 25 132. .681 30. ,512 19. .603 1. 00 47. .79 1SG 181
ATOM 181 N GLN 26 131. .617 32. .433 19. .094 1. .00 46. 58 1SG 182
ATOM 182 CA GLN 26 132, .832 33. .166 18. .894 1. 00 46, ,58 1SG 183
ATOM 183 CB GLN 26 132, .574 34. .670 18. .718 1. .00 46. ,58 1SG 184
ATOM 184 CG GLN 26 131 .664 34. .997 17, .538 1. .00 46. .58 1SG 185
ATOM 185 CD GLN 26 132, .415 34. .647 16 .267 1. .00 46. .58 1SG 186
ATOM 186 OEl GLN 26 132, .930 33. ,541 16. .113 1. 00 46. .58 1SG 187
ATOM 187 NE2 GLN 26 132, .485 35. ,627 15. .329 1. .00 46. .58 1SG 188
ATOM 188 C GLN 26 133 .692 33. .043 20, .109 1. .00 46. .58 1SG 189
ATOM 189 O GLN 26 134, .892 32. .800 19 .999 1. .00 46. .58 1SG 190
ATOM 190 N ARG 27 133 .101 33. .190 21 .307 1. , 00 45. .07 1SG 191
ATOM 191 CA ARG 27 133 .907 33. .164 22 .491 1. .00 45, .07 1SG 192
ATOM 192 CB ARG 27 133, .112 33. .434 23 , .783 1. .00 45. ,07 1SG 193
ATOM 193 CG ARG 27 132, .030 32. .398 24, .093 1. .00 45. .07 1SG 194
ATOM 194 CD ARG 27 131, .206 32. .737 25 .338 1. .00 45. .07 1SG 195
ATOM 195 NE ARG 27 132 .145 32, .831 26, .493 1, .00 45. .07 1SG 196
ATOM 196 CZ ARG 27 132 .423 31 .728 27 .248 1. .00 45. .07 1SG 197
ATOM 197 NH1 ARG 27 131 .847 30 .528 26 .945 1, .00 45 .07 1SG 198
ATOM 198 NH2 ARG 27 133 .277 31 .825 28 .308 1. .00 45. .07 1SG 199
ATOM 199 C ARG 27 134 .554 31, .822 22 .628 1, .00 45. .07 1SG 200
ATOM 200 O ARG 27 135. .740 31, .730 22 .937 1. .00 45. .07 1SG 201
ATOM 201 N ALA 28 133 .799 30, .739 22 .380 1, .00 44. .51 1SG 202
ATOM 202 CA ALA 28 134 .321 29 .411 22 .541 1. .00 44. .51 1SG 203
ATOM 203 CB ALA 28 133 .271 28. .324 22 .250 1. .00 44 .51 1SG 204
ATOM 204 C ALA 28 135 .453 29 .212 21 .585 1. .00 44 .51 1SG 205
ATOM 205 O ALA 28 136 .461 28, .587 21 .911 1. .00 44, .51 1SG 206
ATOM 206 N LEU 29 135. .311 29, .779 20 .377 1, .00 46, .88 1SG 207
ATOM 207 CA LEU 29 136 .231 29, .626 1 .287 1. .00 46 .88 1SG 208
ATOM 208 CB LEU 29 135 .735 30, .326 18 .012 1, .00 46, .88 1SG 209
ATOM 209 CG LEU 29 134 .402 29 .744 17 .499 1, .00 46 .88 1SG 210
ATOM 210 CD2 LEU 29 134 .486 28. .216 17 .338 1 .00 46 .88 1SG 211
ATOM 211 CD1 LEU 29 133 .927 30 .454 16 .222 1, .00 46 .88 1SG 212
ATOM 212 C LEU 29 137 .565 30, .196 19 .664 1, .00 46, .88 1SG 213
ATOM 213 o LEU 29 138 .595 29, .756 19 .157 1, .00 46, .88 1SG 214
ATOM 214 N GLN 30 137 .584 31. .168 20 .589 1 .00 51, .78 1SG 215
ATOM 215 CA GLN 30 138 .787 31 .873 20 .931 1, .00 51, .78 1SG 216 TOM 216 CB GLN 30 138 .617 32 .838 22 .118 1 .00 51 .78 1SG 217
ATOM 217 CG GLN 30 138 .397 32 .125 23 .454 1 .00 51 .78 1SG 218
ATOM 218 CD GLN 30 138 .242 33. .181 2 .540 1, .00 51, .78 1SG 219
ATOM 219 OEl GLN 30 138 .016 32 .860 25 .706 1, .00 51, .78 1SG 220
ATOM 220 NE2 GLN 30 138 .370 34 .477 24 .150 1, .00 51 .78 1SG 221
ATOM 221 C GLN 30 139 .848 30 .896 21 .338 1 .00 51, .78 1SG 222
ATOM 222 O GLN 30 141 .028 31 .169 21 .118 1, .00 51 .78 1SG 223
ATOM 223 N VAL 31 139 .456 29 .751 21 .942 1 .00 56 .80 1SG 224
ATOM 224 CA VAL 31 140 .353 28 .741 22 .446 1 .00 56 .80 1SG 225
ATOM 225 CB VAL 31 139 .684 27, .421 22 .702 1 .00 56, .80 1SG 226 ATOM 226 CGI VAL 31 139,.169 26..869 21..363 1..00 56..80 1SG 227
ATOM 227 CG2 VAL 31 140. .686 26. .495 23, .412 1. .00 56. .80 1SG 228
ATOM 228 C VAL 31 141. .462 28. .506 21. .472 1. .00 56. .80 1SG 229
ATOM 229 o VAL 31 141. .294 28. .649 20. .263 1. .00 56. .80 1SG 230
ATOM 230 N THR 32 142. .648 28. .159 22, .009 1. .00 60, .24 1SG 231
ATOM 231 CA THR 32 143, .836 28. .035 21, .218 1. .00 60. .24 1SG 232
ATOM 232 CB THR 32 145, .071 27. .774 22, .031 1. .00 60. .24 1SG 233
ATOM 233 OG1 THR 32 146, .227 27. .871 21, .213 1. .00 60. .24 1SG 234
ATOM 234 CG2 THR 32 144, .971 26. .367 22, .646 1, .00 60. .24 1SG 235
ATOM 235 C THR 32 143, .700 26. .924 20, .233 1. .00 60, .24 1SG 236
ATOM 236 o THR 32 143, .020 25. .926 20, .466 1. .00 60, .24 1SG 237
ATOM 237 N VAL 33 144, .362 27. .115 19. .076 1. .00 63, .74 1SG 238
ATOM 238 CA VAL 33 144, .400 26. .175 17, .997 1. .00 63, .74 1SG 239
ATOM 239 CB VAL 33 143, .688 26. .645 16 .763 1. .00 63, .74 1SG 240
ATOM 240 CGI VAL 33 142, .226 26. .962 17, .119 1. .00 63, .74 1SG 241
ATOM 241 CG2 VAL 33 144, .462 27. .835 16 .171 1, .00 63, .74 1SG 242
ATOM 242 C VAL 33 145, .842 26. .133 17, .638 1. .00 63, .74 1SG 243
ATOM 243 O VAL 33 146, .644 26, .838 18 .248 1, .00 63, .74 1SG 244
ATOM 244 N PRO 34 146, .229 25, .321 16 .704 1. .00 64 .60 1SG 245
ATOM 245 CA PRO 34 147, .602 25. .374 16 .317 1. .00 64, .60 1SG 246
ATOM 246 CD PRO 34 145, .653 23. .999 16 .525 1. .00 64 .60 1SG 247
ATOM 247 CB PRO 34 147. .819 24, .169 15 .408 1. .00 64 .60 1SG 248
ATOM 248 CG PRO 34 146. .791 23. .144 15 .935 1. .00 64 .60 1SG 249
ATOM 249 C PRO 34 147, .746 26. .709 15 .679 1. .00 64 .60 1SG 250
ATOM 250 O PRO 34 146, .831 27, .121 14 .969 1, .00 64 .60 1SG 251
ATOM 251 N HIS 35 148, .861 27. .413 15 .922 1 .00 65 .95 1SG 252
ATOM 252 CA HIS 35 148, .963 28. .728 15 .374 1 .00 65 .95 1SG 253
ATOM 253 NDl HIS 35 150 .243 28, .847 18 .454 1 .00 65 .95 1SG 254
ATOM 254 CG HIS 35 149, .883 29, .773 17 .500 1 .00 65 .95 1SG 255
ATOM 255 CB HIS 35 150 .072 29, .573 16 .026 1 .00 65 .95 1SG 256
ATOM 256 NE2 HIS 35 149 .393 30, .586 19 .547 1 .00 65 .95 1SG 257
ATOM 257 CD2 HIS 35 149, .365 30, .829 18 .185 1 .00 65 .95 1SG 258
ATOM 258 CE1 HIS 35 149, .928 29, .384 19 .659 1 .00 65 .95 1SG 259
ATOM 259 C HIS 35 149, .311 28, .603 13 .936 1, .00 65 .95 1SG 260
ATOM 260 o HIS 35 150, .069 27, .718 13 .542 1, .00 65 .95 1SG 261
ATOM 261 N PHE 36 148 .732 29, .490 13 .107 1 .00 68 .32 1SG 262
ATOM 262 CA PHE 36 149, .101 29. .510 11 .730 1, .00 68 .32 1SG 263
ATOM 263 CB PHE 36 147. .918 29, .819 10 .801 1, .00 68 .32 1SG 264
ATOM 264 CG PHE 36 147. .010 28, .667 11 .038 1, .00 68 .32 1SG 265
ATOM 265 CD1 PHE 36 147. .128 27, .512 10 .300 1, .00 68 .32 1SG 266
ATOM 266 CD2 PHE 36 146. .058 28, .734 12 .028 1, .00 68, .32 1SG 267
ATOM 267 CE1 PHE 36 146. .294 26, .446 10 .540 1, .00 68 .32 1SG 268
ATOM 268 CE2 PHE 36 145. .223 27, .671 12 .271 1, .00 68, .32 1SG 269
ATOM 269 CZ PHE 36 145, .340 26. .524 11 .524 1, .00 68, .32 1SG 270
ATOM 270 C PHE 36 150, .102 30, .606 11 .674 1, .00 68, .32 1SG 271
ATOM 271 o PHE 36 149, .765 31, .780 11 .812 1, .00 68, .32 1SG 272
ATOM 272 N LEU 37 151, .374 30, .228 11 .468 1, .00 66, .77 1SG 273
ATOM 273 CA LEU 37 152, .461 31, .148 11, .578 1, .00 66, .77 1SG 274
ATOM 274 CB LEU 37 153, .659 30. .503 12 .301 1, .00 66, .77 1SG 275
ATOM 275 CG LEU 37 154, .803 31. .459 12 .678 1, .00 66, .77 1SG 276
ATOM 276 CD2 LEU 37 156, .005 30. .670 13, .224 1, .00 66, .77 1SG 277
ATOM 277 CD1 LEU 37 154, .322 32. .550 13, .649 1, .00 66, .77 1SG 278
ATOM 278 C LEU 37 152, .871 31. .570 10, .204 1, .00 66, .77 1SG 279
ATOM 279 o LEU 37 152, .038 31. .948 9, .382 1. .00 66, .77 1SG 280
ATOM 280 N ASP 38 154, .187 31, .517 9. .927 1, .00 63. .90 1SG 281
ATOM 281 CA ASP 38 154, .716 ■ 31, .945 8, .668 1, .00 63. .90 1SG 282
ATOM 282 CB ASP 38 154 , .231 31. .101 7, .475 1, .00 63. .90 1SG 283 ATOM 283 CG ASP 38 155.,002 31.,527 6..229 1.,00 63..90 1SG 284
ATOM 284 ODl ASP 38 155. ,819 32. ,482 6. .325 1. ,00 63. .90 1SG 285
ATOM 285 OD2 ASP 38 154. .781 30. .899 5. .160 1. .00 63. .90 1SG 286 TOM 286 C ASP 38 154. .310 33. .364 8. .439 1. .00 63. .90 1SG 287
ATOM 287 o ASP 38 153. .764 33. .710 7. .395 1. ,00 63. .90 1SG 288
ATOM 288 N TRP 39 154, .563 34. .226 9. .440 1. .00 58. .44 1SG 289
ATOM 289 CA TRP 39 154 , .255 35. .621 9. .340 1. .00 58. .44 1SG 290
ATOM 290 CB TRP 39 154. .376 36. .342 10. .685 1. .00 58. .44 1SG 291
ATOM 291 CG TRP 39 155. .811 36. .438 11. .152 1. .00 58. .44 1SG 292
ATOM 292 CD2 TRP 39 156, .575 35. .355 11. .704 1. .00 58. .44 1SG 293
ATOM 293 CD1 TRP 39 156. .653 37. .508 11. .092 1. .00 58. .44 1SG 294
ATOM 294 NE1 TRP 39 157. .889 37. .166 11, .584 1. .00 58. .44 1SG 295
ATOM 295 CE2 TRP 39 157. .858 35. .841 11. .959 1. .00 58. .44 1SG 296
ATOM 296 CE3 TRP 39 156, .241 34. .060 11. .969 1. .00 58. .44 1SG 297
ATOM 297 CZ2 TRP 39 158 .828 35. .038 12. .486 1. .00 58. .44 1SG 298
ATOM 298 CZ3 TRP 39 157, .222 33. .255 12. .504 1. .00 58. .44 1SG 299
ATOM 299 CH2 TRP 39 158, .491 33. .732 12. .758 1. .00 58. .44 1SG 300
ATOM 300 C TRP 39 155 .326 36. .245 8, .513 1. .00 58. .44 1SG 301
ATOM 301 o TRP 39 156, .484 35. .830 8. .569 1. .00 58. .44 1SG 302
ATOM 302 N SER 40 154, .978 37. .252 7. .695 1. .00 48. .97 1SG 303
ATOM 303 CA SER 40 156 .031 37. .908 6. .985 1. .00 48. .97 1SG 304
ATOM 304 CB SER 40 156, .815 36. .978 6. .044 1. .00 48. .97 1SG 305
ATOM 305 OG SER 40 157, .835 37. .708 5. .378 1. .00 48. .97 1SG 306
ATOM 306 C SER 40 155 .418 38, .973 6, .141 1, .00 48. .97 1SG 307
ATOM 307 O SER 40 154, .226 38. .942 5. .832 1. .00 48. .97 1SG 308
ATOM 308 N GLY 41 156, .244 39. .959 5. .758 1, .00 43, .52 1SG 309
ATOM 309 CA GLY 41 155 .818 41, .020 4. .898 1, .00 43 .52 1SG 310
ATOM 310 C GLY 41 156 .722 42, .170 5, .186 1. .00 43, .52 1SG 311
ATOM 311 O GLY 41 156, .771 42. .663 6. .312 1, .00 43, .52 1SG 312
ATOM 312 N GLU 42 157 .456 42. .644 4 .163 1 .00 41 .65 1SG 313
ATOM 313 CA GLU 42 158 .374 43, .715 4, .413 1, .00 41, .65 1SG 314
ATOM 314 CB GLU 42 159, .199 44 , .094 3. .172 1, .00 41, .65 1SG 315
ATOM 315 CG GLU 42 160 .144 42, .986 2 .702 1 .00 41 .65 1SG 316
ATOM 316 CD GLU 42 159 .313 41, .938 1. .976 1, .00 41 .65 1SG 317
ATOM 317 OEl GLU 42 158 .834 42 , .240 0. .850 1, .00 41, .65 1SG 318
ATOM 318 OE2 GLU 42 159 .141 40, .824 2. .539 1 .00 41 .65 1SG 319
ATOM 319 C GLU 42 157 .596 44, .927 4, .810 1, .00 41. .65 1SG 320
ATOM 320 o GLU 42 157 .879 45, .552 5. .831 1. .00 41, .65 1SG 321
ATOM 321 N ALA 43 156 .575 45, .278 4. .007 1 .00 43 .21 1SG 322
ATOM 322 CA ALA 43 155 .778 46, .437 4, .285 1, .00 43, .21 1SG 323 TOM 323 CB ALA 43 154 .740 46, .723 3, .187 1, .00 43, .21 1SG 324
ATOM 324 C ALA 43 155 .035 46, .190 5 .551 1, .00 43 .21 1SG 325
ATOM 325 O ALA 43 154 .928 47, .064 6, .410 1, .00 43, .21 1SG 326
ATOM 326 N LEU 44 154 .514 44. .959 5, .691 1, .00 49, .70 1SG 327
ATOM 327 CA LEU 44 153 .743 44. .579 6, .832 1, .00 49, .70 1SG 328
ATOM 328 CB LEU 44 152 .899 43. .310 6, .625 1, .00 49, .70 1SG 329
ATOM 329 CG LEU 44 151 .792 43. .467 5. .568 1. .00 49, .70 1SG 330
ATOM 330 CD2 LEU 44 152 .383 43. .762 4. .181 1, .00 49, .70 1SG 331
ATOM 331 CD1 LEU 44 150 .740 44. .498 6, .007 1, .00 49, .70 1SG 332
ATOM 332 C LEU 44 154 .692 44. .297 7, .943 1, .00 49, .70 1SG 333
ATOM 333 O LEU 44 155 .895 44. .498 7, .830 1, .00 49, .70 1SG 334
ATOM 334 N GLN 45 154 .160 43, .885 9, .096 1, .00 54, .16 1SG 335
ATOM 335 CA GLN 45 155 .020 43, .566 10, .188 1, .00 54, .16 1SG 336
ATOM 336 CB GLN 45 154 .606 44, .266 11, .497 1, .00 54, .16 1SG 337
ATOM 337 CG GLN 45 154 .802 45, .783 11, .462 1, .00 54, .16 1SG 338
ATOM 338 CD GLN 45 154 .363 46 , .351 12, .805 1, .00 54, .16 1SG 339
ATOM 339 OEl GLN 45 154 .709 47, .479 13, .153 1, .00 54. .16 1SG 340 ATOM 340 NE2 GLN 45 153..586 45..551 13..584 1..00 54..16 1SG 341
ATOM 341 C GLN 45 154. .894 42. .090 10. .370 1. .00 54. .16 1SG 342
ATOM 342 O GLN 45 154. .453 41. .396 9. .454 1. .00 54. .16 1SG 343
ATOM 343 N PRO 46 155. .328 41. .569 11. .487 1. .00 59. .10 1SG 344
ATOM 344 CA PRO 46 155. .101 40. .179 11. .734 1. .00 59. .10 1SG 345
ATOM 345 CD PRO 46 156. .529 42. .035 12. .158 1. .00 59. .10 1SG 346
ATOM 346 CB PRO 46 155. .981 39. .811 12. .934 1. .00 59. .10 1SG 347
ATOM 347 CG PRO 46 156. .591 41. .145 13. .407 1. ,00 59. .10 1SG 348
ATOM 348 C PRO 46 153. .637 40. .040 11. .966 1. .00 59. .10 1SG 349
ATOM 349 O PRO 46 153. .057 40. .917 12. .604 1. .00 59. .10 1SG 350
ATOM 350 N THR 47 153. .006 38. .970 11. .452 1. .00 64. .47 1SG 351
ATOM 351 CA THR 47 151. .592 38. .880 11, .636 1. .00 64, .47 1SG 352
ATOM 352 CB THR 47 150. .835 39. .419 10. .453 1. .00 64, .47 1SG 353
ATOM 353 OG1 THR 47 149, .434 39. .332 10, .660 1. .00 64, .47 1SG 354
ATOM 354 CG2 THR 47 151, .232 38, .613 9, .207 1. .00 64, .47 1SG 355
ATOM 355 C THR 47 151, .221 37, .446 11, .780 1, .00 64, .47 1SG 356
ATOM 356 O THR 47 151, .674 36. .594 11, .020 1, .00 6 .47 1SG 357
ATOM 357 N ARG 48 150. .356 37. .141 12. .762 1. .00 69, .30 1SG 358
ATOM 358 CA ARG 48 149. .918 35, .788 12. .881 1. .00 69, .30 1SG 359
ATOM 359 CB ARG 48 149. .831 35, .280 14, .329 1. .00 69, .30 1SG 360
ATOM 360 CG ARG 48 148 , .914 36. .109 15, .224 1. .00 69, .30 1SG 361
ATOM 361 CD ARG 48 149, .514 36, .296 16. .616 1. .00 69, .30 1SG 362
ATOM 362 NE ARG 48 150. .823 36, .977 16, .403 1. .00 69, .30 1SG 363
ATOM 363 CZ ARG 48 151. .801 36. .929 17. .353 1. .00 69 .30 1SG 364
ATOM 364 NH1 ARG 48 151. .587 36. .267 18. .527 1. .00 69 .30 1SG 365
ATOM 365 NH2 ARG 48 152 .999 37, .543 17. .124 1, .00 69 .30 1SG 366
ATOM 366 C ARG 48 148, .569 35 .751 12, .256 1, .00 69 .30 1SG 367
ATOM 367 O ARG 48 147 .717 36 .593 12 .535 1. .00 69 .30 1SG 368
ATOM 368 N ILE 49 148, .353 34, .771 11, .364 1. .00 74, .49 1SG 369
ATOM 369 CA ILE 49 147, .116 34, .728 10, .653 1. .00 74, .49 1SG 370
ATOM 370 CB ILE 49 147, .343 34, .665 9, .166 1. .00 74, .49 1SG 371
ATOM 371 CG2 ILE 49 148, .452 35, .700 8, .898 1. .00 74, .49 1SG 372
ATOM 372 CGI ILE 49 147, .815 33, .275 8, .696 1. .00 74, .49 1SG 373
ATOM 373 CD1 ILE 49 149, .122 32, .811 9, .336 1. .00 74, .49 1SG 374
ATOM 374 C ILE 49 146, .477 33 .451 11, .085 1. .00 74, .49 1SG 375
ATOM 375 O ILE 49 147 .153 32 .433 11, .208 1, .00 74, .49 1SG 376
ATOM 376 N ARG 50 145 .166 33 .456 11, .383 1, .00 76 .32 1SG 377
ATOM 377 CA ARG 50 144 .665 32 .186 11 .810 1. .00 76 .32 1SG 378
ATOM 378 CB ARG 50 144 .929 31 .868 13, .299 1. .00 76 .32 1SG 379
ATOM 379 CG ARG 50 146 , .378 31, .532 13 , .660 1. .00 76. .32 1SG 380
ATOM 380 CD ARG 50 146, .595 31, .232 15, .141 1. .00 76. .32 1SG 381
ATOM 381 NE ARG 50 146, .280 32, .483 15, .886 1. .00 76. .32 1SG 382
ATOM 382 CZ ARG 50 147, .266 33, .387 16, .161 1. .00 76, .32 1SG 383
ATOM 383 NH1 ARG 50 148, .546 33, .144 15, .756 1. .00 76, .32 1SG 384
ATOM 384 NH2 ARG 50 146, .973 34. .529 16, .849 1. .00 76, .32 1SG 385
ATOM 385 C ARG 50 143, .189 32. .126 11, .671 1. .00 76, .32 1SG 386
ATOM 386 o ARG 50 142, .516 33, .133 11, .447 1. .00 76, .32 1SG 387
ATOM 387 N ILE 51 142 .671 30 .884 11, .750 1. .00 76, .98 1SG 388
ATOM 388 CA ILE 51 141, .268 30 .712 11 .908 1. .00 76, .98 1SG 389
ATOM 389 CB ILE 51 140 .720 29 .459 11 .296 1, .00 76, .98 1SG 390
ATOM 390 CG2 ILE 51 141 .192 28 .271 12 .155 1, .00 76, .98 1SG 391
ATOM 391 CGI ILE 51 139, .188 29, .546 11, .194 1. .00 76. .98 1SG 392
ATOM 392 CD1 ILE 51 138, .565 28. .430 10, .359 1. .00 76. .98 1SG 393
ATOM 393 C ILE 51 141, .208 30, .485 13, .374 1. .00 76. .98 1SG 394
ATOM 394 o ILE 51 140. .191 30, .092 13, .941 1. .00 76. .98 1SG 395
ATOM 395 N LEU 52 142. .368 30, .700 14 , .020 1. .00 76. .11 1SG 396
ATOM 396 CA LEU 52 142. .415 30, .652 15, .442 1. .00 76, .11 1SG 397 ATOM 397 CB LEU 52 143..833 30..716 16,.030 1..00 76..11 1SG 398
ATOM 398 CG LEU 52 143. .842 30. .774 17, .572 1. .00 76, .11 1SG 399
ATOM 399 CD2 LEU 52 145, .261 30. .996 18 .116 1, .00 76, .11 1SG 400
ATOM 400 CD1 LEU 52 143. .160 29. .545 18 .193 1. .00 76 .11 1SG 401
ATOM 401 C LEU 52 141. .698 31. .864 15, .887 1. .00 76, .11 1SG 402
ATOM 402 O LEU 52 140, .896 31. .830 16, .818 1. .00 76, .11 1SG 403
ATOM 403 N ASN 53 141, .982 32. .982 15 .197 1. .00 75 .54 1SG 404
ATOM 404 CA ASN 53 141. .308 34. .187 15 .537 1. .00 75 .54 1SG 405
ATOM 405 CB ASN 53 142. .179 35. .448 15, .416 1. .00 75, .54 1SG 406
ATOM 406 CG ASN 53 141. .502 36. .540 16, .231 1. .00 75, .54 1SG 407
ATOM 407 OD1 ASN 53 141, .346 36, .401 17 .443 1. .00 75 .54 1SG 408
ATOM 408 ND2 ASN 53 141, .089 37, .650 15 .564 1. .00 75 .54 1SG 409
ATOM 409 C ASN 53 140, .235 34. .278 14, .531 1. .00 75, .54 1SG 410
ATOM 410 O ASN 53 140, .503 34. .446 13, .344 1, .00 75, .54 1SG 411
ATOM 411 N VAL 54 138, .980 34. .115 14 .969 1. .00 75 .57 1SG 412
ATOM 412 CA VAL 54 137, .987 34, .169 13 .964 1. .00 75 .57 1SG 413
ATOM 413 CB VAL 54 137. .240 32. .890 13, .753 1, .00 75 .57 1SG 414
ATOM 414 CGI VAL 54 136. .089 33. .173 12 .776 1. .00 75 .57 1SG 415
ATOM 415 CG2 VAL 54 138, .213 31, .831 13 .235 1. .00 75 .57 1SG 416
ATOM 416 C VAL 54 136, .945 35, .140 1 .343 1. .00 75 .57 1SG 417
ATOM 417 O VAL 54 136, .294 35, .025 15, .381 1 .00 75 .57 1SG 418
ATOM 418 N HIS 55 136, .769 36. .146 13, .485 1. .00 73 .93 1SG 419
ATOM 419 CA HIS 55 135. .606 36. .933 13 .645 1. .00 73 .93 1SG 420
ATOM 420 ND1 HIS 55 134. .063 39. .576 14 .882 1. .00 73 .93 1SG 421
ATOM 421 CG HIS 55 134, .531 39, .222 13 .637 1, .00 7 .93 1SG 422
ATOM 422 CB HIS 55 135, .791 38, .435 13 .404 1. .00 73 .93 1SG 423
ATOM 423 NE2 HIS 55 132, .615 40, .391 13 .405 1, .00 73 .93 1SG 424
ATOM 424 CD2 HIS 55 133, .636 39 .726 12 .746 1, .00 73 .93 1SG 425
ATOM 425 CE1 HIS 55 132, .914 40 .274 14 .684 1, .00 73 .93 1SG 426
ATOM 426 C HIS 55 134, .801 36, .387 12 .537 1, .00 73, .93 1SG 427
ATOM 427 O HIS 55 135, .215 36, .457 11 .381 1. .00 73 .93 1SG 428
ATOM 428 N VAL 56 133, .664 35 .756 12 .858 1. .00 70 .95 1SG 429
ATOM 429 CA VAL 56 132, .949 35 .179 11 .773 1, .00 70 .95 1SG 430
ATOM 430 CB VAL 56 132, .194 33, .933 12 .110 1, .00 70. .95 1SG 431
ATOM 431 CGI VAL 56 131, .413 33, .542 10 .849 1, .00 70, .95 1SG 432
ATOM 432 CG2 VAL 56 133, .166 32, .851 12 .602 1, .00 70, .95 1SG 433
ATOM 433 C VAL 56 131, .932 36 .166 11 .342 1, .00 70 .95 1SG 434
ATOM 434 o VAL 56 130, .876 36. .321 11, .954 1. .00 70 .95 1SG 435
ATOM 435 N PRO 57 132, .280 36, .857 10 .301 1, .00 65, .84 1SG 436
ATOM 436 CA PRO 57 131, .394 37, .808 9 .712 1, .00 65, .84 1SG 437
ATOM 437 CD PRO 57 133, .257 36, .368 9 .349 1, .00 65, .84 1SG 438
ATOM 438 CB PRO 57 132. .112 38, .313 8, .477 1, .00 65 .84 1SG 439
ATOM 439 CG PRO 57 132. .911 37, .076 8, .030 1. .00 65. .84 1SG 440
ATOM 440 C PRO 57 130, .170 37, .084 9 .275 1. .00 65. .84 1SG 441
ATOM 441 O PRO 57 129, .071 37, .618 9 .418 1. .00 65. .84 1SG 442
ATOM 442 N ARG 58 130. .342 35, .869 8 .716 1. .00 60. .45 1SG 443
ATOM 443 CA ARG 58 129. .195 35, .201 8, .197 1. .00 60. .45 1SG 444
ATOM 444 CB ARG 58 129, .119 35. .241 6, .660 1. .00 60. .45 1SG 445
ATOM 445 CG ARG 58 128, .912 36. .648 6 .097 1. .00 60. .45 1SG 446
ATOM 446 CD ARG 58 127. .440 37 .026 5 .925 1. .00 60. .45 1SG 447
ATOM 447 NE ARG 58 126. .857 37. .209 7, .284 1. .00 60. .45 1SG 448
ATOM 448 CZ ARG 58 125, .563 37. .625 7, .412 1. .00 60. .45 1SG 449
ATOM 449 NH1 ARG 58 124, .813 37, .863 6, .298 1. .00 60. .45 1SG 450
ATOM 450 NH2 ARG 58 125, .019 37, .802 8 .651 1, .00 60. .45 1SG 451
ATOM 451 C ARG 58 129. .206 33, .763 8, .593 1. .00 60. .45 1SG 452
ATOM 452 O ARG 58 130. .198 33. .051 8, .439 1. .00 60. ,45 1SG 453
ATOM 453 N LEU 59 128. .063 33, .318 9, .142 1. .00 54. .98 1SG 454 ATOM 454 CA LEU 59 127.816 31.943 9..435 1.00 54.98 1SG 455
ATOM 455 CB LEU 59 127. ,455 31. ,599 10. .896 1. .00 54. ,98 1SG 456
ATOM 456 CG LEU 59 128. .587 31. .705 11. .936 1, ,00 54. .98 1SG 457
ATOM 457 CD2 LEU 59 129. .904 31. .092 11. .445 1. .00 54. .98 1SG 458
ATOM 458 CD1 LEU 59 128. .144 31. .078 13. .265 1. .00 54. ,98 1SG 459
ATOM 459 C LEU 59 126. .599 31. .643 8. .640 1. .00 54. .98 1SG 460
ATOM 460 O LEU 59 125. .857 32. .555 8. .277 1. .00 54. .98 1SG 461
ATOM 461 N HIS 60 126, .373 30. .364 8. .305 1. .00 50. .66 1SG 462
ATOM 462 CA HIS 60 125. ,202 30. .094 7. .532 1. 00 50. .66 1SG 463
ATOM 463 ND1 HIS 60 123. .484 30. .756 4. .675 1. ,00 50. .66 1SG 464
ATOM 464 CG HIS 60 124, .270 29. .748 5. .189 1. ,00 50. .66 1SG 465
ATOM 465 CB HIS 60 125. .494 29. .979 6. ,025 1. .00 50. .66 1SG 466
ATOM 466 NE HIS 60 122. .577 28. .841 4. .004 1. .00 50, .66 1SG 467
ATOM 467 CD2 HIS 60 123. .701 28. .585 4. .770 1. .00 50, .66 1SG 468
ATOM 468 CE1 HIS 60 122. .488 30. .158 3. ,975 1. ,00 50. .66 1SG 469
ATOM 469 C HIS 60 124. .646 28, .785 7 , .975 1, .00 50. .66 1SG 470
ATOM 470 O HIS 60 125. .384 27. .893 8. .391 1. .00 50, .66 1SG 471
ATOM 471 N LEU 61 123. .306 28. .670 7. .930 1. ,00 47, .11 1SG 472
ATOM 472 CA LEU 61 122. .637 27. .439 8. .226 1, .00 47, .11 1SG 473
ATOM 473 CB LEU 61 121. .536 27. .545 9, .292 1. .00 47, .11 1SG 474
ATOM 474 CG LEU 61 122 .052 27. .530 10 .735 1. .00 47 .11 1SG 475
ATOM 475 CD2 LEU 61 122. .897 26. .273 10, .970 1. .00 47 .11 1SG 476
ATOM 476 CD1 LEU 61 120, .899 27. .644 11, .746 1. .00 47, .11 1SG 477
ATOM 477 C LEU 61 121 .943 27. .014 6, .980 1. .00 47 .11 1SG 478
ATOM 478 O LEU 61 121, .023 27, .683 6 , .508 1, .00 47 .11 1SG 479
ATOM 479 N LYS 62 122, .369 25. .865 6 , .423 1. .00 43, .45 1SG 480
ATOM 480 CA LYS 62 121 .756 25. .353 5, .235 1. .00 43 .45 1SG 481
ATOM 481 CB LYS 62 122, .778 24, .743 4, .258 1. .00 43 .45 1SG 482
ATOM 482 CG LYS 62 122 .301 24, .613 2 .808 1, .00 43 .45 1SG 483
ATOM 483 CD LYS 62 121, .126 23, .660 2, .584 1. .00 43 .45 1SG 484
ATOM 484 CE LYS 62 120, .707 23, .583 1, .113 1, ,00 43 .45 1SG 485
ATOM 485 NZ LYS 62 119 .706 22, .512 0 .914 1, .00 43 .45 1SG 486
ATOM 486 C LYS 62 120 .851 24, .269 5, .710 1, ,00 43 .45 1SG 487
ATOM 487 O LYS 62 121. .126 23. .620 6, .717 1, .00 43 .45 1SG 488
ATOM 488 N PHE 63 119 .724 24. .051 5 .012 1, .00 39 .24 1SG 489
ATOM 489 CA PHE 63 118 .824 23. .069 5, .524 1. ,00 39 .24 1SG 490
ATOM 490 CB PHE 63 117 .403 23 .661 5 .628 1. .00 39 .24 1SG 491
ATOM 491 CG PHE 63 116 .631 22. .978 6 .705 1 .00 39 .24 1SG 492
ATOM 492 CD1 PHE 63 117 .233 22, .670 7, .903 1. .00 39 .24 1SG 493
ATOM 493 CD2 PHE 63 115 .284 22 .745 6, .565 1. .00 39 .24 1SG 494
ATOM 494 CE1 PHE 63 116 .521 22, .061 8, .909 1, .00 39 .24 1SG 495
ATOM 495 CE2 PHE 63 114 .560 22 .142 7 .566 1, .00 39 .24 1SG 496
ATOM 496 CZ PHE 63 115 .184 21, .791 8, .739 1, .00 39 .24 1SG 497
ATOM 497 C PHE 63 118, .909 21. .912 4 , .583 1, .00 39, .24 1SG 498
ATOM 498 O PHE 63 118 .702 22. .060 3 .380 1, .00 39 .24 1SG 499
ATOM 499 N ILE 64 119 .267 20 .725 5 .112 1 .00 3 .86 1SG 500
ATOM 500 CA ILE 64 119, .385 19. .574 4 , .269 1. .00 34, .86 1SG 501
ATOM 501 CB ILE 64 120 .620 18. .756 4, .541 1. .00 34 .86 1SG 502
ATOM 502 CG2 ILE 64 120 .667 18. .401 6, .035 1. ,00 34, .86 1SG 503
ATOM 503 CGI ILE 64 120 .691 17 .554 3, .586 1. .00 34 .86 1SG 504
ATOM 504 CD1 ILE 64 122 .048 16. .851 3, .593 1, .00 34 .86 1SG 505
ATOM 505 C ILE 64 118 .169 18. .752 4 , .525 1. .00 34, .86 1SG 506
ATOM 506 O ILE 64 117 .963 18. .231 5, .620 1, .00 34 .86 1SG 507
ATOM 507 N ALA 65 117 .327 18 .612 3 .487 1, .00 30 .61 1SG 508
ATOM 508 CA ALA 65 116 .059 17 .972 3 .653 1, .00 30 .61 1SG 509
ATOM 509 CB ALA 65 115 .225 17, .921 2 , .362 1, .00 30 .61 1SG 510
ATOM 510 C ALA 65 116, .241 16, .571 4. ,130 1. .00 30, .61 1SG 511 ( n <' ι ^_ ^ B) lI^ O ri t. n « ln ^<) ^ o) <Λ O H N ι«ι ^ l(l lI) t(l Ol O H M ι, 'J| lll u) CD l^ι O ri lN ι, * ι) lβ αJ m o ^l f« (. * l/l «) ^^)
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90 r-
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Figure imgf000173_0003
O
O
Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ Σ
P P d O d P P O P P O P O P P P P P P P P O P d O O O d O O P P O P P P P P d P O O O P P O P P P O P d d P P d P
H H H H H H H H H H H H H H h H H H E→ H H H .H _H H H B _H H H H _H H H H H H H _H EH H H
ATOM 568 C ALA 73 133..277 30..420 8,.796 1..00 77..26 1SG 569
ATOM 569 O ALA 73 133. .611 29. .920 7, .721 1. ,00 77. .26 1SG 570
ATOM 570 N ALA 74 133. .961 31. .491 9. .360 1. ,00 80. .57 1SG 571
ATOM 571 CA ALA 74 135, .002 32. .359 8. .757 1. ,00 80. .57 1SG 572
ATOM 572 CB ALA 74 134. .476 33. .763 8. .426 1. ,00 80. .57 1SG 573
ATOM 573 C ALA 74 136. .298 32, .563 9. .601 1. .00 80, .57 1SG 574
ATOM 574 O ALA 74 136. .602 31, .716 10 .440 1. .00 80, .57 1SG 575
ATOM 575 N ALA 75 137, .128 33, .665 9, .360 1. .00 77, .96 1SG 576
ATOM 576 CA ALA 75 138, .467 33, .857 9, .969 1. .00 77, .96 1SG 577
ATOM 577 CB ALA 75 139, .602 33, .285 9, .099 1. .00 77. .96 1SG 578
ATOM 578 C ALA 75 138, .899 35. .297 10. .306 1. ,00 77. .96 1SG 579
ATOM 579 O ALA 75 138 .199 36. .268 10 .020 1. .00 77 .96 1SG 580
ATOM 580 N ASN 76 140, .100 35. .448 10 .967 1. .00 72 .04 1SG 581
ATOM 581 CA ASN 76 140, .694 36, .714 11. .401 1. .00 72, .04 1SG 582
ATOM 582 CB ASN 76 140, .354 37, .132 12. .844 1. .00 72, .04 1SG 583
ATOM 583 CG ASN 76 138, .985 37, .792 12. .888 1. .00 72, .04 1SG 584
ATOM 584 OD1 ASN 76 138, .335 38. .014 11, .867 1. .00 72, .04 1SG 585
ATOM 585 ND2 ASN 76 138, .545 38. .147 14, .125 1. .00 72 .04 1SG 586
ATOM 586 C ASN 76 142 .214 36 .686 11 .338 1, .00 72 .04 1SG 587
ATOM 587 O ASN 76 142 .825 35 .644 11 .106 1. .00 72 .04 1SG 588
ATOM 588 N PHE 77 142 .855 37 .871 11 .558 1, .00 66 .09 1SG 589
ATOM 589 CA PHE 77 144, .286 38, .098 11 .477 1. .00 66 .09 1SG 590
ATOM 590 CB PHE 77 144, .663 38, .833 10, .177 1. .00 66 .09 1SG 591
ATOM 591 CG PHE 77 144 , .818 37, .807 9, .112 1. .00 66 .09 1SG 592
ATOM 592 CD1 PHE 77 143 .834 36 .874 8 .863 1. .00 66 .09 1SG 593
ATOM 593 CD2 PHE 77 145 .996 37 .742 8 .403 1. .00 66 .09 1SG 594
ATOM 594 CE1 PHE 77 144, .009 35, .919 7 .886 1, .00 66 .09 1SG 595
ATOM 595 CE2 PHE 77 146, .169 36, .793 7 .423 1, .00 66 .09 1SG 596
ATOM 596 CZ PHE 77 145, .175 35, .884 7 .164 1, .00 66 .09 1SG 597
ATOM 597 C PHE 77 144, .764 38, .948 12 .624 1, .00 66 .09 1SG 598
ATOM 598 O PHE 77 143 .985 39, .656 13 .257 1. .00 66 .09 1SG 599
ATOM 599 N THR 78 146 .082 38 .885 12 .936 1, .00 60 .48 1SG 600
ATOM 600 CA THR 78 146, .612 39 .702 13 .993 1, .00 60 .48 1SG 601
ATOM 601 CB THR 78 146, .974 38 .936 15 .234 1, .00 60 .48 1SG 602
ATOM 602 OG1 THR 78 145, .833 38, .273 15 .757 1, .00 60 .48 1SG 603
ATOM 603 CG2 THR 78 147, .543 39. .913 16 .276 1, .00 60 .48 1SG 604
ATOM 604 C THR 78 147, .867 40. .367 13, .522 1. .00 60 .48 1SG 605
ATOM 605 o THR 78 148 .836 39 .715 13 .135 1. .00 60 .48 1SG 606
ATOM 606 N PHE 79 147 .863 41 .709 13 .569 1. .00 58 .18 1SG 607
ATOM 607 CA PHE 79 148, .983 42 .538 13 .256 1, .00 58 .18 1SG 608
ATOM 608 CB PHE 79 148, .523 43, .888 12, .676 1, .00 58 .18 1SG 609
ATOM 609 CG PHE 79 149. .606 44, .510 11, .865 1. .00 58 .18 1SG 610
ATOM 610 CD1 PHE 79 149, .695 44, .227 10, .520 1. .00 58 .18 1SG 611
ATOM 611 CD2 PHE 79 150 .516 45, .375 12 .425 1. .00 58 .18 1SG 612
ATOM 612 CE1 PHE 79 150, .677 44, .789 9 .740 1, .00 58 .18 1SG 613
ATOM 613 CE2 PHE 79 151, .502 45, .940 11 .649 1. .00 58 .18 1SG 614
ATOM 614 CZ PHE 79 151. .585 45, .650 10 .307 1. .00 58 .18 1SG 615
ATOM 615 C PHE 79 149, .498 42. .770 14, .635 1. .00 58, .18 1SG 616
ATOM 616 o PHE 79 148 , .752 42. .530 15, .582 1. .00 58, .18 1SG 617
ATOM 617 N LYS 80 150, .766 43. .186 14, .816 1. .00 56, .79 1SG 618
ATOM 618 CA LYS 80 151, .219 43. .299 16 .175 1. .00 56 .79 1SG 619
ATOM 619 CB LYS 80 152, .669 43. .800 16 .279 1. .00 56 .79 1SG 620
ATOM 620 CG LYS 80 153, .301 43. .590 17, .658 1. .00 56 .79 1SG 621
ATOM 621 CD LYS 80 152. .587 44. .306 18, .808 1. .00 56, .79 1SG 622
ATOM 622 CE LYS 80 152. .932 45. .792 18, .925 1. .00 56, .79 1SG 623
ATOM 623 NZ LYS 80 152. .190 46. .387 20, .059 1. .00 56, .79 1SG 624
ATOM 624 C LYS 80 150. .353 44. .288 16 .885 1. .00 56 .79 1SG 625 ATOM 625 O LYS 80 149..728 43.,964 17..892 1..00 56..79 1SG 626
ATOM 626 N VAL 81 150. .252 45. .507 16. .335 1. .00 55. .13 1SG 627
ATOM 627 CA VAL 81 149. .458 46. .517 16. .959 1. .00 55. .13 1SG 628
ATOM 628 CB VAL 81 149. .691 47. .883 16, .380 1. ,00 55. .13 1SG 629
ATOM 629 CGI VAL 81 151. .162 48. .268 16, .611 1. ,00 55. .13 1SG 630
ATOM 630 CG2 VAL 81 149. .272 47. .876 14, .902 1. .00 55, .13 1SG 631
ATOM 631 C VAL 81 148. .001 46. ,215 16. .814 1. .00 55. .13 1SG 632
ATOM 632 O VAL 81 147. ,236 46. ,361 17. .766 1. .00 55. .13 1SG 633
ATOM 633 N PHE 82 147. .562 45. .741 15. .632 1. .00 55. .82 1SG 634
ATOM 634 CA PHE 82 146. .138 45. .747 15. .482 1. ,00 55. .82 1SG 635
ATOM 635 CB PHE 82 145. .710 46. .672 14. .326 1. .00 55. .82 1SG 636
ATOM 636 CG PHE 82 144. .289 47. .078 14, .505 1. .00 55. .82 1SG 637
ATOM 637 CD1 PHE 82 143. .991 48. .186 15, .265 1. .00 55. .82 1SG 638
ATOM 638 CD2 PHE 82 143. .260 46. .378 13, .924 1. .00 55. .82 1SG 639
ATOM 639 CE1 PHE 82 142. .691 48. .589 15, .450 1. .00 55. .82 1SG 640
ATOM 640 CE2 PHE 82 141, .956 46. .776 14, .105 1. .00 55, .82 1SG 641
ATOM 641 CZ PHE 82 141, .669 47. .883 14 .867 1. .00 55, .82 1SG 642
ATOM 642 C PHE 82 145. .620 44. .370 15, .221 1. .00 55. .82 1SG 643
ATOM 643 O PHE 82 146. .334 43. .482 14, .760 1. .00 55, .82 1SG 644
ATOM 644 N ARG 83 144. .328 44. .166 15, .544 1. .00 59, .27 1SG 645
ATOM 645 CA ARG 83 143. .691 42. .900 15, .345 1. .00 59, .27 1SG 646
ATOM 646 CB ARG 83 142. .923 42. .434 16, .588 1. .00 59, .27 1SG 647
ATOM 647 CG ARG 83 141. .859 43. .452 17, .000 1. .00 59, .27 1SG 648
ATOM 648 CD ARG 83 140. .947 42. .999 18 .139 1. .00 59, .27 1SG 649
ATOM 649 NE ARG 83 141. .601 43. .377 19 .422 1. .00 59 .27 1SG 650
ATOM 650 CZ ARG 83 140. .848 43. .909 20 .428 1. .00 59 .27 1SG 651
ATOM 651 NH1 ARG 83 139. .513 44. .113 20 .237 1. .00 59 .27 1SG 652
ATOM 652 NH2 ARG 83 141. .430 44. .232 21 .620 1. .00 59 .27 1SG 653
ATOM 653 C ARG 83 142. .676 43. .100 14, .267 1. .00 59, .27 1SG 654
ATOM 654 O ARG 83 141. .887 44 , .042 14, .322 1. .00 59, .27 1SG 655
ATOM 655 N ALA 84 142. .674 42. .228 13 .239 1. .00 65, .26 1SG 656
ATOM 656 CA ALA 84 141. .692 42. .410 12 .214 1. .00 65, .26 1SG 657
ATOM 657 CB ALA 84 142, .282 42, .435 10 .794 1. .00 65 .26 1SG 658
ATOM 658 C ALA 84 140, .731 41, .264 12 .280 1. .00 65 .26 1SG 659
ATOM 659 O ALA 84 141, .060 40. .100 12 .051 1, .00 65 .26 1SG 660
ATOM 660 N PRO 85 139, .556 41. .642 12 .696 1. .00 74 .09 1SG 661
ATOM 661 CA PRO 85 138, .398 40, .790 12 .778 1. .00 74 .09 1SG 662
ATOM 662 CD PRO 85 139, .470 42, .752 13 .631 1. .00 74 .09 1SG 663
ATOM 663 CB PRO 85 137, .550 41 .333 13 .927 1. .00 74 .09 1SG 664
ATOM 664 CG PRO 85 138 .002 42 .793 14 .071 1, .00 74 .09 1SG 665
ATOM 665 C PRO 85 137, .632 40, .784 11 .498 1. .00 74, .09 1SG 666
ATOM 666 O PRO 85 136, .524 40, .258 11 .501 1. .00 74, .09 1SG 667
ATOM 667 N GLU 86 138, .178 41. .367 10 .418 1. .00 82, .37 1SG 668
ATOM 668 CA GLU 86 137, .468 41, .611 9 .196 1. .00 82, .37 1SG 669
ATOM 669 CB GLU 86 138. .395 41, .965 8 .022 1. .00 82, .37 1SG 670
ATOM 670 CG GLU 86 137. .667 42, .236 6 .705 1. .00 82, .37 1SG 671
ATOM 671 CD GLU 86 138. .727 42, .579 5 .670 1. .00 82, .37 1SG 672
ATOM 672 OEl GLU 86 139. .823 43, .037 6 .087 1. .00 82, .37 1SG 673
ATOM 673 OE2 GLU 86 138. .460 42, .387 4 .453 1. .00 82, .37 1SG 674
ATOM 674 C GLU 86 136. .624 40, .454 8 .789 1, .00 82, .37 1SG 675
ATOM 675 O GLU 86 136. .868 39, .279 9 .064 1. .00 82, .37 1SG 676
ATOM 676 N PRO 87 135. .536 40. .905 8, .230 1. .00 90. .56 1SG 677
ATOM 677 CA PRO 87 134. .542 40. .039 7 .679 1. .00 90. .56 1SG 678
ATOM 678 CD PRO 87 134. .992 42. .192 8 .630 1. .00 90. .56 1SG 679
ATOM 679 CB PRO 87 133. .337 40. .937 7 .385 1. .00 90, .56 1SG 680
ATOM 680 CG PRO 87 133. .480 42, .090 8 .392 1. .00 90, .56 1SG 681
ATOM 681 C PRO 87 135. .123 39, .444 6 .447 1. .00 90, .56 1SG 682
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ATOM 739 CB GLU 95 134.492 27.285 6..787 1..00 75,.25 1SG 740
ATOM 740 CG GLU 95 134 .265 25 .920 6 .123 1 .00 75, .25 1SG 741
ATOM 741 CD GLU 95 135, .335 25 .666 5. .073 1. .00 75. .25 1SG 742
ATOM 742 OEl GLU 95 136, .546 25. .701 5, .416 1, .00 75, .25 1SG 743
ATOM 743 OE2 GLU 95 134, .949 25 .438 3. .897 1. .00 75, .25 1SG 744
ATOM 744 C GLU • 95 135 .136 26 .057 8 .755 1 .00 75, .25 1SG 745
ATOM 745 O GLU 95 135 .483 24 .935 8 .388 1 .00 75, .25 1SG 746
ATOM 746 N LEU 96 134 .420 26 .259 9 .870 1 .00 62 .23 1SG 747
ATOM 747 CA LEU 96 134, .039 25. .130 10. .653 1. .00 62, .23 1SG 748
ATOM 748 CB LEU 96 133, .940 25. .441 12. .161 1. .00 62. .23 1SG 749
ATOM 749 CG LEU 96 133 .600 24 .236 13 .068 1, .00 62, .23 1SG 750
ATOM 750 CD2 LEU 96 134 .649 23 .122 12 .917 1 .00 62, .23 1SG 751
ATOM 751 CD1 LEU 96 132 .161 23 .732 12 .871 1 .00 62, .23 1SG 752
ATOM 752 C LEU 96 132 .690 24 .742 10 .159 1 .00 62 .23 1SG 753
ATOM 753 O LEU 96 131, .796 25, .580 10. .042 1, .00 62, .23 1SG 754
ATOM 754 N LEU 97 132, .536 23, .448 9. .824 1, .00 51, .19 1SG 755
ATOM 755 CA LEU 97 131 .293 22 .932 9 .340 1 .00 51, .19 1SG 756
ATOM 756 CB LEU 97 131 .447 22 .109 8 .050 1 .00 51 .19 1SG 757
ATOM 757 CG LEU 97 130 .128 21 .501 7 .540 1 .00 51 .19 1SG 758
ATOM 758 CD2 LEU 97 130, .383 20, .454 6. .442 1, .00 51. .19 1SG 759
ATOM 759 CD1 LEU 97 129, .136 22 .592 7. .111 1, .00 51. .19 1SG 760
ATOM 760 C LEU 97 130, .786 21 .994 10, .379 1 .00 51. .19 1SG 761
ATOM 761 O LEU 97 131, .512 21 .115 10 .843 1 .00 51, .19 1SG 762
ATOM 762 N ALA 98 129 .518 22 .166 10 .788 1 .00 43 .92 1SG 763
ATOM 763 CA ALA 98 128 .993 21 .261 11 .762 1 .00 43 .92 1SG 764
ATOM 764 CB ALA 98 128, .848 21, .878 13 , .164 1, .00 43 , .92 1SG 765
ATOM 765 C ALA 98 127, .633 20 .857 11, .306 1, .00 43, .92 1SG 766
ATOM 766 O ALA 98 126, .908 21 .648 10, .704 1, .00 43 , .92 1SG 767
ATOM 767 N ASP 99 127, .266 19 .590 11, .572 1 .00 38 .74 1SG 768
ATOM 768 CA ASP 99 125 .976 19 .103 11 .191 1 .00 38 .74 1SG 769
ATOM 769 CB ASP 99 125 .992 17 .662 10 .651 1 .00 38 .74 1SG 770
ATOM 770 CG ASP 99 126, .725 17, .650 9, .319 1, .00 38. .74 1SG 771
ATOM 771 OD1 ASP 99 127, .139 18. .747 8, .856 1, .00 38. .74 1SG 772
ATOM 772 OD2 ASP 99 126, .879 16 .541 8, .742 1, .00 38. .74 1SG 773
ATOM 773 C ASP 99 125, .142 19 .083 12, .427 1 .00 38 .74 1SG 774
ATOM 774 O ASP 99 125 .554 18 .546 13, .455 1 .00 38 .74 1SG 775
ATOM 775 N THR 100 123. .941 19. .684 12. .363 1, .00 36. .83 1SG 776
ATOM 776 CA THR 100 123, .091 19. .683 13, .513 1, .00 36, .83 1SG 777
ATOM 777 CB THR 100 122, .482 21, .022 13, .809 1, .00 36, .83 1SG 778
ATOM 778 OG1 THR 100 121, .652 21. .433 12 , .732 1, .00 36, .83 1SG 779
ATOM 779 CG2 THR 100 123, .615 22 .040 14, .024 1. .00 36 , .83 1SG 780
ATOM 780 C THR 100 121, .974 18 .741 13, .220 1, .00 36, .83 1SG 781
ATOM 781 O THR 100 121. .280 18, .874 12. .213 1. .00 36. .83 1SG 782
ATOM 782 N ARG 101 121. .782 17. .747 14. .106 1. .00 36. .40 1SG 783
ATOM 783 CA ARG 101 120. .741 16. .789 13. .895 1. .00 36. .40 1SG 784
ATOM 784 CB ARG 101 121. .188 15, .339 14 , .154 1. .00 36. .40 1SG 785
ATOM 785 CG ARG 101 120, .114 14, .295 13. .847 1, .00 36. .40 1SG 786
ATOM 786 CD ARG 101 120, .570 12, .858 14, .111 1, .00 36, .40 1SG 787
ATOM 787 NE ARG 101 121. .719 12. .577 13. .205 1. .00 36. .40 1SG 788
ATOM 788 CZ ARG 101 122. .595 11, .577 13. .511 1. .00 36. .40 1SG 789
ATOM 789 NH1 ARG 101 122. .415 10. .836 14. .643 1. .00 36. .40 1SG 790
ATOM 790 NH2 ARG 101 123. .653 11. .318 12. .687 1. .00 36. .40 1SG 791
ATOM 791 C ARG 101 119. .663 17, .110 14. .871 1. .00 36. .40 1SG 792
ATOM 792 O ARG 101 119. ,931 17. ,395 16. ,038 1. ,00 36. .40 1SG 793
ATOM 793 N VAL 102 118. ,401 17. .089 14. .405 1. ,00 35. .62 1SG 794
ATOM 794 CA VAL 102 117. .322 17. .402 15. .287 1. ,00 35. .62 1SG 795
ATOM 795 CB VAL 102 116. .343 18. .385 14. .715 1. .00 35. .62 1SG 796 ATOM 796 CGI VAL 102 115..696 17..760 13..468 1..00 35..62 1SG 797
ATOM 797 CG2 VAL 102 115. .333 18. .761 15. .812 1. .00 35. .62 1SG 798
ATOM 798 C VAL 102 116. .575 16. .139 15, .553 1. .00 35. .62 1SG 799
ATOM 799 O VAL 102 116. .302 15, .354 14 , .647 1. .00 35. .62 1SG 800
ATOM 800 N THR 103 116. .244 15, .906 16. .833 1. .00 35. .34 1SG 801
ATOM 801 CA THR 103 115. .507 14. .739 17. .195 1. ,00 35. .34 1SG 802
ATOM 802 CB THR 103 116 .364 13 .610 17 .689 1. .00 35. .34 1SG 803
ATOM 803 OG1 THR 103 115. .584 12 .435 17, .853 1. .00 35. .34 1SG 804
ATOM 804 CG2 THR 103 116, .999 14 .022 19 .028 1, .00 35. .34 1SG 805
ATOM 805 C THR 103 114, .625 15 .147 18, .318 1. .00 35, .34 1SG 806
ATOM 806 O THR 103 114, .586 16. .316 18, .698 1. .00 35, .34 1SG 807
ATOM 807 N GLN 104 113, .854 14, .196 18, .864 1. .00 36, .44 1SG 808
ATOM 808 CA GLN 104 113, .058 14, .573 19, .982 1. .00 36, .44 1SG 809
ATOM 809 CB GLN 104 111, .613 14, .931 19, .646 1. .00 36, .44 1SG 810
ATOM 810 CG GLN 104 111, .539 16, .300 18, .985 1. .00 36. .44 1SG 811
ATOM 811 CD GLN 104 110, .081 16, .547 18, .702 1. .00 36. .44 1SG 812
ATOM 812 OEl GLN 104 109, .240 15, .731 19, .075 1. .00 36. .44 1SG 813
ATOM 813 NE2 GLN 104 109 .765 17 .663 17, .992 1. .00 36 .44 1SG 814
ATOM 814 C GLN 104 113, .067 13 .465 20, .962 1, .00 36. .44 1SG 815
ATOM 815 O GLN 104 113, .331 12 .311 20, .631 1. .00 36. .44 1SG 816
ATOM 816 N SER 105 112, .802 13 .820 22 .228 1. .00 40 .85 1SG 817
ATOM 817 CA SER 105 112, .782 12, .814 23, .232 1, .00 40. .85 1SG 818
ATOM 818 CB SER 105 113, .461 13, .231 24, .545 1. .00 40. .85 1SG 819
ATOM 819 OG SER 105 113, .395 12, .170 25, .485 1. .00 40. .85 1SG 820
ATOM 820 C SER 105 111, .347 12, .571 23, .526 1. .00 40. .85 1SG 821
ATOM 821 O SER 105 110, .528 13, .488 23, .523 1. .00 40. .85 1SG 822
ATOM 822 N SER 106 111. .010 11, .304 23, .803 1. .00 46. .68 1SG 823
ATOM 823 CA SER 106 109. .655 10, .976 24. .099 1. .00 46, .68 1SG 824
ATOM 824 CB SER 106 109 .450 9 .477 2 .376 1, .00 46 .68 1SG 825
ATOM 825 OG SER 106 109. .744 8 .722 23 .209 1, .00 46 .68 1SG 826
ATOM 826 C SER 106 109 .313 11 .722 25 .344 1, .00 46 .68 1SG 827
ATOM 827 O SER 106 108. .139 11 .950 25 .630 1, .00 46, .68 1SG 828
ATOM 828 N ILE 107 110. .338 12 .143 26, .116 1, .00 52, .29 1SG 829
ATOM 829 CA ILE 107 110. .020 12, .879 27. .296 1. .00 52, .29 1SG 830
ATOM 830 CB ILE 107 Ill, .127 12, .854 28, .312 1, .00 52, .29 1SG 831
ATOM 831 CG2 ILE 107 112, .370 13, .518 27, .696 1, .00 52, .29 1SG 832
ATOM 832 CGI ILE 107 110, .659 13, .482 29, .635 1. .00 52, .29 1SG 833
ATOM 833 CD1 ILE 107 111. .607 13, .214 30, .804 1, .00 52, .29 1SG 834
ATOM 834 C ILE 107 109. .777 14, .316 26, .894 1. .00 52, .29 1SG 835
ATOM 835 O ILE 107 110. .244 15, .244 27. .552 1. .00 52. .29 1SG 836
ATOM 836 N ARG 108 108. .996 14, .490 25. .797 1, .00 52. .96 1SG 837
ATOM 837 CA ARG 108 108. .395 15, .674 25. .228 1, .00 52. .96 1SG 838
ATOM 838 CB ARG 108 107, .383 16, .310 26. .198 1. .00 52, .96 1SG 839
ATOM 839 CG ARG 108 106, .270 15, .354 26, .636 1. .00 52, .96 1SG 840
ATOM 840 CD ARG 108 105. .262 15, .983 27, .600 1. .00 52, .96 1SG 841
ATOM 841 NE ARG 108 105. .974 16, .259 28, .879 1. .00 52. .96 1SG 842
ATOM 842 CZ ARG 108 106. .026 15. .300 29. .849 1. .00 52. .96 1SG 843
ATOM 843 NH1 ARG 108 105, .434 14. .088 29. .643 1. .00 52. .96 1SG 844
ATOM 844 NH2 ARG 108 106 , .671 15. .553 31. .026 1. .00 52. .96 1SG 845
ATOM 845 C ARG 108 109. .349 16. .765 24. .821 1. .00 52. .96 1SG 846
ATOM 846 O ARG 108 108. .889 17. .792 24. .326 1. ,00 52. .96 1SG 847
ATOM 847 N THR 109 110. .679 16. .592 24, .936 1. .00 47. .16 1SG 848
ATOM 848 CA THR 109 111. .517 17, .725 24 , .633 1. .00 47. .16 1SG 849
ATOM 849 CB THR 109 112. .532 18. .009 25, .703 1. .00 47. .16 1SG 850
ATOM 850 OG1 THR 109 111. .879 18. .257 26. .939 1. .00 47. .16 1SG 851
ATOM 851 CG2 THR 109 113. .364 19. .235 25. .289 1. .00 47. .16 1SG 852
ATOM 852 C THR 109 112. .273 17. .473 23. .367 1. ,00 47. .16 1SG 853 ATOM 853 O THR 109 112..536 16.335 22,.982 1..00 47..16 1SG 854
ATOM 854 N PRO 110 112. .589 18. .550 22. .694 1. ,00 39. .70 1SG 855
ATOM 855 CA PRO 110 113. .348 18 .481 21, .474 1. .00 39. .70 1SG 856
ATOM 856 CD PRO 110 111. .775 19 .751 22, .761 1. .00 39. .70 1SG 857
ATOM 857 CB PRO 110 113. .106 19 .805 20. .744 1. ,00 39. .70 1SG 858
ATOM 858 CG PRO 110 112, .478 20 .727 21, .806 1. .00 39. .70 1SG 859
ATOM 859 C PRO 110 114, .785 18 .223 21, .780 1. .00 39, .70 1SG 860
ATOM 860 O PRO 110 115, .231 18. .546 22, .880 1. .00 39. .70 1SG 861
ATOM 861 N VAL 111 115, .532 17 .632 20, .828 1. .00 33, .36 1SG 862
ATOM 862 CA VAL 111 116, .914 17 .370 21, .087 1. .00 33, .36 1SG 863
ATOM 863 CB VAL 111 117, .218 15, .915 21, .295 1. .00 33, .36 1SG 864
ATOM 864 CGI VAL 111 118. .740 15 .749 21 .442 1. .00 33, .36 1SG 865
ATOM 865 CG2 VAL 111 116. .414 15 .415 22, .507 1. .00 33, .36 1SG 866
ATOM 866 C VAL 111 117, .698 17 .809 19, .896 1. ,00 33 , .36 1SG 867
ATOM 867 O VAL 111 117, .214 17 .772 18, .766 1. .00 33, .36 1SG 868
ATOM 868 N VAL 112 118. .940 18 .265 20, .140 1. .00 31, .09 1SG 869
ATOM 869 CA VAL 112 119. .809 18 .656 19, .074 1. ,00 31, .09 1SG 870
ATOM 870 CB VAL 112 119 .896 20 .140 18 .883 1. .00 31 .09 1SG 871
ATOM 871 CGI VAL 112 120, .970 20 .436 17, .823 1. .00 31, .09 1SG 872
ATOM 872 CG2 VAL 112 118. .499 20, .661 18, .511 1. .00 31, .09 1SG 873
ATOM 873 C VAL 112 121 .169 18 .174 19 .450 1, .00 31 .09 1SG 874
ATOM 874 O VAL 112 121. .589 18 .296 20 .600 1. .00 31, .09 1SG 875
ATOM 875 N SER 113 121. .895 17, .600 18, .476 1. .00 32, .78 1SG 876
ATOM 876 CA SER 113 123 .208 17 .112 18 .763 1, .00 32 .78 1SG 877
ATOM 877 CB SER 113 123. .258 15 .593 19 .001 1. .00 32 .78 1SG 878
ATOM 878 OG SER 113 122. .847 14, .900 17. .831 1. .00 32, .78 1SG 879
ATOM 879 C SER 113 124 .050 17 .411 17 .572 1, .00 32 .78 1SG 880
ATOM 880 O SER 113 123. .538 17 .735 16 .501 1. .00 32, .78 1SG 881
ATOM 881 N ILE 114 125, .381 17, .322 17. .739 1. .00 39, .26 1SG 882
ATOM 882 CA ILE 114 126 .250 17 .593 16 .638 1, .00 39 .26 1SG 883
ATOM 883 CB ILE 114 127, .406 18 .483 17 .039 1. .00 39 .26 1SG 884
ATOM 884 CG2 ILE 114 128, .180 17, .798 18. .175 1. .00 39, .26 1SG 885
ATOM 885 CGI ILE 114 128 .265 18 .908 15 .836 1, .00 39 .26 1SG 886
ATOM 886 CD1 ILE 114 129, .066 17 .775 15 .200 1, .00 39 .26 1SG 887
ATOM 887 C ILE 114 126, .720 16, .265 16. .130 1. .00 39 .26 1SG 888
ATOM 888 O ILE 114 127 .469 15 .547 16 .791 1, .00 39 .26 1SG 889
ATOM 889 N SER 115 126, .229 15 .892 14 .932 1. .00 44, .21 1SG 890
ATOM 890 CA SER 115 126, .552 14, .634 14, .326 1. .00 44, .21 1SG 891
ATOM 891 CB SER 115 125 .774 14 .387 13 .024 1. .00 44 .21 1SG 892
ATOM 892 OG SER 115 124. .380 14 .367 13 .281 1. .00 44, .21 1SG 893
ATOM 893 C SER 115 127, .995 14, .617 13, .961 1. .00 44, .21 1SG 894
ATOM 894 O SER 115 128 .752 13 .758 14 .412 1. .00 44 .21 1SG 895
ATOM 895 N ALA 116 128, .412 15 .583 13, .122 1. .00 51, .44 1SG 896
ATOM 896 CA ALA 116 129, .775 15, .590 12, .689 1. .00 51, .44 1SG 897
ATOM 897 CB ALA 116 129 .976 14 .970 11 .296 1. .00 51, .44 1SG 898
ATOM 898 C ALA 116 130, .227 17, .005 12, .606 1. .00 51, .44 1SG 899
ATOM 899 O ALA 116 129, .444 17. .913 12, .327 1. .00 51, .44 1SG 900
ATOM 900 N CYS 117 131, .525 17 .223 12 .872 1. .00 62, .38 1SG 901
ATOM 901 CA CYS 117 132, .072 18. .539 12. .810 1. .00 62, .38 1SG 902
ATOM 902 CB CYS 117 132, .335 19. .152 14. .192 1. .00 62. .38 1SG 903
ATOM 903 SG CYS 117 133, .618 18, .207 15 .057 1, .00 62. .38 1SG 904
ATOM 904 C CYS 117 133, .398 18, .387 12, .171 1. .00 62. .38 1SG 905
ATOM 905 O CYS 117 134. .049 17, .349 12, .290 1. .00 62. .38 1SG 906
ATOM 906 N SER 118 133. .824 19, .420 11 .436 1, .00 69, .88 1SG 907
ATOM 907 CA SER 118 135. .127 19. .320 10, .881 1. .00 69, .88 1SG 908
ATOM 908 CB SER 118 135. .278 18. .165 9, .875 1. .00 69. .88 1SG 909
ATOM 909 OG SER 118 134. .420 18. .369 8, .762 1. .00 69. .88 1SG 910 ATOM 910 C SER 118 135.,378 20.,582 10.,152 1.,00 69.,88 1SG 911
ATOM 911 O SER 118 134. .467 21. .174 9. .575 1. .00 69. .88 1SG 912
ATOM 912 N LEU 119 136. .636 21. ,042 10. .184 1. .00 76. ,82 1SG 913
ATOM 913 CA LEU 119 136. .953 22. 158 9. 363 1. 00 76. 82 1SG 914
ATOM 914 CB LEU 119 138, .345 22. .728 9. .678 1. .00 76. .82 1SG 915
ATOM 915 CG LEU 119 138, .794 23. .974 8. .885 1. .00 76. .82 1SG 916
ATOM 916 CD2 LEU 119 138. .036 25. .233 9. ,328 1. .00 76. .82 1SG 917
ATOM 917 CD1 LEU 119 138. , 792 23. .733 7. .367 1. .00 76. ,82 1SG 918
ATOM 918 C LEU 119 137. .008 21, .487 8. .037 1. .00 76. .82 1SG 919
ATOM 919 O LEU 119 137, .657 20. .452 7. .904 1. .00 76. .82 1SG 920
ATOM 920 N PHE 120 136. .322 22. ,014 7. .012 1. ,00 78. .30 1SG 921
ATOM 921 CA PHE 120 136, .383 21. .237 5. .817 1. .00 78. .30 1SG 922
ATOM 922 CB PHE 120 135, .021 20. .716 5. .317 1, .00 78, .30 1SG 923
ATOM 923 CG PHE 120 134, .156 21. .861 4. .921 1. .00 78. .30 1SG 924
ATOM 924 CD1 PHE 120 133, .395 22. ,526 5. .855 1. .00 78. .30 1SG 925
ATOM 925 CD2 PHE 120 134, .097 22. .260 3. .606 1. .00 78. .30 1SG 926
ATOM 926 CE1 PHE 120 132, .593 23. ,579 5. .482 1. .00 78. .30 1SG 927
ATOM 927 CE2 PHE 120 133, .298 23. .312 3. .228 1. .00 78, .30 1SG 928
ATOM 928 CZ PHE 120 132 .544 23 , ,974 4, .167 1. .00 78, .30 1SG 929
ATOM 929 C PHE 120 136, .997 22. .062 4 , .758 1. .00 78, .30 1SG 930
ATOM 930 O PHE 120 136, .853 23. ,279 4. .726 1. .00 78. .30 1SG 931
ATOM 931 N SER 121 137 .736 21, .386 3, .866 1. .00 72. .79 1SG 932
ATOM 932 CA SER 121 138 .360 22, .091 2, .807 1, .00 72 .79 1SG 933
ATOM 933 CB SER 121 139, .870 21, ,813 2. .696 1, .00 72, .79 1SG 934
ATOM 934 OG SER 121 140, .431 22. .544 1. .616 1. .00 72, .79 1SG 935
ATOM 935 C SER 121 137 .730 21, .569 1 .568 1, .00 72 .79 1SG 936
ATOM 936 O SER 121 137 .517 20, .368 1. .410 1, .00 72 .79 1SG 937
ATOM 937 N GLY 122 137 .400 22. ,488 0, .656 1, .00 62, .83 1SG 938
ATOM 938 CA GLY 122 136 .820 22. .116 -0, .590 1, .00 62 .83 1SG 939
ATOM 939 C GLY 122 137 .561 22 .961 -1 .550 1 .00 62 .83 1SG 940
ATOM 940 O GLY 122 138 .497 23. .657 -1, .161 1, .00 62 .83 1SG 941
ATOM 941 N HIS 123 137 .188 22. .920 -2 , .835 1, .00 55, .10 1SG 942
ATOM 942 CA HIS 123 137 .909 23. .787 -3, .703 1, .00 55 .10 1SG 943
ATOM 943 ND1 HIS 123 139 .488 24 .262 -6 .640 1 .00 55 .10 1SG 944
ATOM 944 CG HIS 123 138 .264 24, .570 -6 .090 1, .00 55 .10 1SG 945
ATOM 945 CB HIS 123 137 .499 23, .656 -5, .179 1, .00 55 .10 1SG 946
ATOM 946 NE2 HIS 123 138 .954 26, ,291 -7, .374 1 .00 55 .10 1SG 947
ATOM 947 CD2 HIS 123 137, .953 25. ,813 -6 .548 1 .00 55 .10 1SG 948
ATOM 948 CE1 HIS 123 139 .855 25. .325 -7, .399 1, .00 55 .10 1SG 949
ATOM 949 C HIS 123 137 .564 25. .161 -3 .249 1 .00 55 .10 1SG 950
ATOM 950 O HIS 123 136 .391 25. .513 -3, .144 1, .00 55 .10 1SG 951
ATOM 951 N ALA 124 138, .582 25. .978 -2, .932 1 .00 48 .94 1SG 952
ATOM 952 CA ALA 124 138 .216 27. .297 -2 .539 1 .00 48 .94 1SG 953
ATOM 953 CB ALA 124 139 .227 27, .965 -1, .592 1 .00 48 .94 1SG 954
ATOM 954 C ALA 124 138 .215 28. .064 -3, .809 1, .00 48, .94 1SG 955
ATOM 955 O ALA 124 139, .247 28. .582 -4. .234 1. .00 48, .94 1SG 956
ATOM 956 N ASN 125 137 .027 28 .166 -4 .433 1 .00 47 .47 1SG 957
ATOM 957 CA ASN 125 136 .949 28, .819 -5, .700 1. .00 47 .47 1SG 958
ATOM 958 CB ASN 125 135 .525 28. .847 -6, .279 1, .00 47, .47 1SG 959
ATOM 959 CG ASN 125 135 .609 29, .391 -7. .700 1, .00 47, .47 1SG 960
ATOM 960 OD1 ASN 125 136 .637 29 .920 -8 .119 1 .00 47 .47 1SG 961
ATOM 961 ND2 ASN 125 134 .491 29, .264 -8, .463 1, .00 47 .47 1SG 962
ATOM 962 C ASN 125 137 .379 30. ,221 -5, .492 1, .00 47, .47 1SG 963
ATOM 963 O ASN 125 138 .223 30, .736 -6, .223 1, .00 47, .47 1SG 964
ATOM 964 N GLU 126 136 .819 30. .882 -4, .466 1 .00 53 .45 1SG 965
ATOM 965 CA GLU 126 137 .253 32. .226 -4, .287 1, .00 53, .45 1SG 966
ATOM 966 CB GLU 126 136 .372 33, .258 -5, .011 1, .00 53 .45 1SG 967 θ H ( rι * ιn ι_ oι <n o H CN -. in vo r~ 00 CSV O H ( Cl -.
O O O O O O O O O O -1 H H (N CN CM CN CN
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ATOM 1024 CA SER 134 144..578 43..020 2..498 1..00 50..99 1SG1025
ATOM 1025 CB SER 134 143. .831 42. .556 3. .756 1. .00 50. .99 1SG1026
ATOM 1026 OG SER 134 143. .555 43. .675 4. .585 1. ,00 50. .99 1SG1027
ATOM 1027 C SER 134 144. ,902 41. .837 1. .635 1. .00 50. .99 1SG1028
ATOM 1028 O SER 134 144. ,513 40. .703 1. .918 1. 00 50. ,99 1SG1029
ATOM 1029 N HIS 135 145. .682 42. .088 0. .567 1. .00 54. .27 1SG1030
ATOM 1030 CA HIS 135 146. .016 41. .099 -0. .417 1. ,00 54. .27 1SG1031
ATOM 1031 ND1 HIS 135 148. .045 43. .738 -0. .799 1. ,00 54. .27 1SG1032
ATOM 1032 CG HIS 135 148. .029 42. .423 -1. .210 1. ,00 54. .27 1SG1033
ATOM 1033 CB HIS 135 146. .787 41. .687 -1. .612 1. .00 54. .27 1SG1034
ATOM 1034 NE2 HIS 135 150. .149 43. .024 -0. .725 1. ,00 54. .27 1SG1035
ATOM 1035 CD2 HIS 135 149. .323 42. .003 -1, .159 1. .00 54. .27 1SG1036
ATOM 1036 CE1 HIS 135 149. .337 44. .045 -0. .521 1. .00 54. .27 1SG1037
ATOM 1037 C HIS 135 146. .853 40. .031 0, .193 1. .00 54, .27 1SG1038
ATOM 1038 O HIS 135 146. .747 38. .861 -0. .173 1. .00 54 , .27 1SG1039
ATOM 1039 N ALA 136 147. .710 40. .407 1. .154 1. .00 56, .65 1SG1040
ATOM 1040 CA ALA 136 148. .629 39. .455 1. .690 1. ,00 56. .65 1SG1041
ATOM 1041 CB ALA 136 149. .492 40. .038 2. .824 1. ,00 56, .65 1SG1042
ATOM 1042 C ALA 136 147. .889 38 .293 2. .259 1. .00 56, .65 1SG1043
ATOM 1043 O ALA 136 148. .274 37 .151 2. .014 1. .00 56, .65 1SG1044
ATOM 1044 N LEU 137 146. .804 38. .522 3, .026 1. .00 60, .24 1SG1045
ATOM 1045 CA LEU 137 146. .176 37. .366 3. .600 1. .00 60, .24 1SG1046
ATOM 1046 CB LEU 137 145. .194 37, .588 4. .765 1. .00 60, .24 1SG1047
ATOM 1047 CG LEU 137 144. .248 38, .776 4. .665 1. .00 60, .24 1SG1048
ATOM 1048 CD2 LEU 137 143. .238 38 .631 3 .518 1. .00 60 .24 1SG1049
ATOM 1049 CD1 LEU 137 145. .077 40 .059 4. .653 1. .00 60 .24 1SG1050
ATOM 1050 C LEU 137 145, .532 36 .503 2. .573 1. .00 60 .24 1SG1051
ATOM 1051 O LEU 137 145. .495 35 .286 2. .734 1. .00 60, .24 1SG1052
ATOM 1052 N LEU 138 144. .983 37, .094 1. .502 1. .00 58, .75 1SG1053
ATOM 1053 CA LEU 138 144. .332 36, .284 0, .519 1. .00 58, .75 1SG1054
ATOM 1054 CB LEU 138 143, .754 37 .122 -0, .635 1. .00 58, .75 1SG1055
ATOM 1055 CG LEU 138 143. .057 36 .286 -1, .725 1, .00 58 .75 1SG1056
ATOM 1056 CD2 LEU 138 142, .758 37 .135 -2, .972 1. .00 58 .75 1SG1057
ATOM 1057 CD1 LEU 138 141, .815 35 .566 -1, .182 1. .00 58 .75 1SG1058
ATOM 1058 C LEU 138 145, .332 35 .350 -0, .073 1. .00 58, .75 1SG1059
ATOM 1059 O LEU 138 145, .084 34, .150 -0. .180 1. .00 58, .75 1SG1060
ATOM 1060 N VAL. 139 146. .505 35. .882 -0, .459 1. .00 56, .38 1SG1061
ATOM 1061 CA VAL 139 147. .512 35 .068 -1 .066 1. .00 56 .38 1SG1062
ATOM 1062 CB VAL 139 148. .714 35 .854 -1, .496 1. .00 56 .38 1SG1063
ATOM 1063 CGI VAL 139 149, .762 34 .877 -2 .055 1. .00 56, .38 1SG1064
ATOM 1064 CG2 VAL 139 148, .262 36 .929 -2, .499 1. .00 56, .38 1SG1065
ATOM 1065 C VAL 139 147, .971 34 .063 -0, .065 1. .00 56, .38 1SG1066
ATOM 1066 O VAL 139 148. .154 32 .887 -0, .376 1. .00 56, .38 1SG1067
ATOM 1067 N LEU 140 148, .147 34 .518 1 .184 1, .00 55 .35 1SG1068
ATOM 1068 CA LEU 140 148, .663 33 .682 2 .219 1. .00 55, .35 1SG1069
ATOM 1069 CB LEU 140 148, .753 34 .408 3 .580 1. .00 55, .35 1SG1070
ATOM 1070 CG LEU 140 149, .780 35 .557 3 .660 1. .00 55, .35 1SG1071
ATOM 1071 CD2 LEU 140 151, .180 35 .093 3, .235 1. .00 55, .35 1SG1072
ATOM 1072 CD1 LEU 140 149. .775 36 .207 5, .055 1. .00 55. .35 1SG1073
ATOM 1073 C LEU 140 147. .754 32. .510 2, .440 1. .00 55. .35 1SG1074
ATOM 1074 O LEU 140 148. .214 31 .372 2 .532 1. .00 55 .35 1SG1075
ATOM 1075 N VAL 141 146. .431 32 .749 2 .508 1. .00 53. .33 1SG1076
ATOM 1076 CA VAL 141 145. .547 31 .688 2, .892 1. .00 53, .33 1SG1077
ATOM 1077 CB VAL 141 144. .105 32. .120 2, .968 1. .00 53, .33 1SG1078
ATOM 1078 CGI VAL 141 143. .975 33. .165 4, .089 1. .00 53, .33 1SG1079
ATOM 1079 CG2 VAL 141 143. .643 32, .635 1. .596 1. .00 53. .33 1SG1080
ATOM 1080 C VAL 141 145, .652 30 .529 1, .959 1. .00 53 .33 1SG1081 ATOM 1081 O VAL 141 145..849 29..395 2..398 1..00 53..33 1SG1082
ATOM 1082 N GLN 142 145. .543 30. .778 0. .645 1. .00 55. ,01 1SG1083
ATOM 1083 CA GLN 142 145. .595 29. .685 -0. .277 1. .00 55. .01 1SG1084
ATOM 1084 CB GLN 142 145. .320 30. .080 -1. .741 1. .00 55. .01 1SG1085
ATOM 1085 CG GLN 142 143. .888 30. .540 -2. .021 1. .00 55. .01 1SG1086
ATOM 1086 CD GLN 142 143. .819 32. .046 -1, .821 1. .00 55. .01 1SG1087
ATOM 1087 OEl GLN 142 144, .695 32. .778 -2. .278 1, .00 55. .01 1SG1088
ATOM 1088 NE2 GLN 142 142, .749 32. .522 -1. .129 1. .00 55. .01 1SG1089
ATOM 1089 C GLN 142 146, .956 29. .086 -0. .248 1. .00 55. .01 1SG1090
ATOM 1090 O GLN 142 147. .112 27. .868 -0. .324 1. .00 55. .01 1SG1091
ATOM 1091 N LYS 143 147. .977 29. .945 -0. .112 1. .00 59. .93 1SG1092
ATOM 1092 CA LYS 143 149, .334 29, .518 -0, .245 1. .00 59. .93 1SG1093
ATOM 1093 CB LYS 143 150. .330 30, .662 0. .017 1. .00 59, .93 1SG1094
ATOM 1094 CG LYS 143 151 .772 30, .336 -0. .376 1, .00 59. .93 1SG1095
ATOM 1095 CD LYS 143 152 .688 31, .562 -0. .390 1, .00 59. .93 1SG1096
ATOM 1096 CE LYS 143 154. .133 31. .246 -0. .782 1. .00 59. .93 1SG1097
ATOM 1097 NZ LYS 143 154. .942 32. .485 -0. .770 1. .00 59. .93 1SG1098
ATOM 1098 C LYS 143 149. .641 28. .413 0, .710 1. .00 59. .93 1SG1099
ATOM 1099 O LYS 143 150 .199 27, .398 0. .296 1. .00 59. .93 1SG1100
ATOM 1100 N HIS 144 149 .294 28, .532 2, .007 1. .00 64. .46 1SG1101
ATOM 1101 CA HIS 144 149 .719 27, .414 2. .797 1, .00 64. .46 1SG1102
ATOM 1102 ND1 HIS 144 152 .729 28, .766 1. .823 1, .00 64. .46 1SG1103
ATOM 1103 CG HIS 144 152. .219 27, .619 2. .388 1. .00 64. .46 1SG1104
ATOM 1104 CB HIS 144 151. .119 27. .600 3. .407 1. .00 64. .46 1SG1105
ATOM 1105 NE2 HIS 144 153. .846 27. .066 0, .924 1. .00 64. .46 1SG1106
ATOM 1106 CD2 HIS 144 152 .912 26. .589 1, .828 1. .00 64. .46 1SG1107
ATOM 1107 CE1 HIS 144 153 .699 28. .378 0, .956 1. .00 64, .46 1SG1108
ATOM 1108 C HIS 144 148 .802 27 .145 3. .946 1. .00 64, .46 1SG1109
ATOM 1109 O HIS 144 148 .726 26, .016 4. .426 1. .00 64, .46 1SG1110
ATOM 1110 N ILE 145 148 .097 28 .175 4, .429 1. .00 69, .16 1SG1111
ATOM llll CA ILE 145 147, .318 28, .061 5. .628 1. .00 69. .16 1SG1112
ATOM 1112 CB ILE 145 146 .824 29, .404 6. .105 1. .00 69. .16 1SG1113
ATOM 1113 CG2 ILE 145 145. .673 29, .837 5, .191 1. .00 69. .16 1SG1114
ATOM 1114 CGI ILE 145 146 .426 29, .378 7, .589 1. .00 69. .16 1SG1115
ATOM 1115 CD1 ILE 145 145 .183 28 .547 7, .899 1, .00 69. .16 1SG1116
ATOM 1116 C ILE 145 146 .157 27 .134 5, .476 1. .00 69. .16 1SG1117
ATOM 1117 O ILE 145 145 .852 26 .366 6, .388 1. .00 69. .16 1SG1118
ATOM 1118 N LYS 146 145 .492 27, .155 4. .309 1, .00 71. .44 1SG1119
ATOM 1119 CA LYS 146 144, .248 26, .462 4 , .164 1. .00 71. .44 1SG1120
ATOM 1120 CB LYS 146 143, .703 26, .524 2 , .726 1. .00 71. .44 1SG1121
ATOM 1121 CG LYS 146 143 .348 27, .943 2. .278 1. .00 71. .44 1SG1122
ATOM 1122 CD LYS 146 142 .282 28, .610 3, .150 1. .00 71. .44 1SG1123
ATOM 1123 CE LYS 146 141 .929 30, .031 2 , .705 1. .00 71. .44 1SG1124
ATOM 1124 NZ LYS 146 141 .127 29 .990 1, .461 1, .00 71. .44 1SG1125
ATOM 1125 C LYS 146 144 .348 25 .016 4 , .546 1. .00 71. .44 1SG1126
ATOM 1126 O LYS 146 143, .470 24 , .510 5. .240 1. .00 71. .44 1SG1127
ATOM 1127 N ALA 147 145, .405 24 , .300 4. .132 1. .00 70. .06 1SG1128
ATOM 1128 CA ALA 147 145, .435 22, .886 4. .398 1. .00 70. ,06 1SG1129
ATOM 1129 CB ALA 147 146, .647 22, .195 3. .751 1. .00 70. .06 1SG1130
ATOM 1130 C ALA 147 145 .464 22, .537 5. .870 1. .00 70. .06 1SG1131
ATOM 1131 O ALA 147 144 .726 21, .660 6. .314 1. .00 70. .06 1SG1132
ATOM 1132 N VAL 148 146 .326 23, .207 6. .656 1. .00 69. .84 1SG1133
ATOM 1133 CA VAL 148 146, .627 22. .917 8. .042 1. .00 69. .84 1SG1134
ATOM 1134 CB VAL 148 147, .888 23. .595 8. .491 1. .00 69. .84 1SG1135
ATOM 1135 CGI VAL 148 149, .064 23. .019 7. .683 1. .00 69. ,84 1SG1136
ATOM 1136 CG2 VAL 148 147, .713 25. .113 8. .326 1. .00 69. ,84 1SG1137
ATOM 1137 C VAL 148 145, .557 23. .255 9. .058 1. .00 69. .84 1SG1138 ATOM 1138 O VAL 148 145..543 22 ,.686 10..147 1..00 69..84 1SG1139
ATOM 1139 N LEU 149 144. .653 24. .192 8. .736 1. .00 70. .76 1SG1140
ATOM 1140 CA LEU 149 143. .766 24. .911 9. .625 1. ,00 70. .76 1SG1141
ATOM 1141 CB LEU 149 142 .912 25. .900 8. .818 1. .00 70. .76 1SG1142
ATOM 1142 CG LEU 149 142. .239 26. .986 9. .668 1. .00 70. ,76 1SG1143
ATOM 1143 CD2 LEU 149 141, .021 27. .589 8. .959 1. .00 70. .76 1SG1144
ATOM 1144 CD1 LEU 149 143, .270 28, .045 10. .089 1. .00 70. .76 1SG1145
ATOM 1145 C LEU 149 142, .784 24. .133 10. .508 1. .00 70. .76 1SG1146
ATOM 1146 O LEU 149 142 .464 24. .606 11, .597 1. .00 70. .76 1SG1147
ATOM 1147 N SER 150 142 .257 22, .967 10, .086 1. .00 71, .91 1SG1148
ATOM 1148 CA SER 150 141 .091 22, .275 10, .623 1, .00 71. .91 1SG1149
ATOM 1149 CB SER 150 140, .757 21, .032 9. .778 1. .00 71. .91 1SG1150
ATOM 1150 OG SER 150 140, .466 21, .409 8, .441 1. .00 71. .91 1SG1151
ATOM 1151 C SER 150 140, .980 21. .800 12. .072 1. .00 71, .91 1SG1152
ATOM 1152 O SER 150 139 .861 21 .760 12. .583 1, .00 71. .91 1SG1153
ATOM 1153 N ASN 151 142 .047 21. .409 12. .791 1. .00 73. .56 1SG1154
ATOM 1154 CA ASN 151 141 .854 20. .646 14, .017 1. .00 73, .56 1SG1155
ATOM 1155 CB ASN 151 143, .202 20, .207 14 , .622 1. .00 73 , .56 1SG1156
ATOM 1156 CG ASN 151 142, .958 19, .145 15, .689 1. .00 73 , .56 1SG1157
ATOM 1157 OD1 ASN 151 142, .327 19, .384 16, .718 1. .00 73. .56 1SG1158
ATOM 1158 ND2 ASN 151 143 .486 17 .917 15 .436 1. .00 73, .56 1SG1159
ATOM 1159 C ASN 151 141 .035 21 .232 15, .161 1, .00 73, .56 1SG1160
ATOM 1160 O ASN 151 140 .072 20, .605 15, .600 1. .00 73 , .56 1SG1161
ATOM 1161 N LYS 152 141, .381 22, .420 15, .696 1. .00 74 , .10 1SG1162
ATOM 1162 CA LYS 152 140. .811 22, .927 16, .933 1, .00 74 , .10 1SG1163
ATOM 1163 CB LYS 152 141 .593 24 .115 17 .507 1 .00 74, .10 1SG1164
ATOM 1164 CG LYS 152 141 .009 24 .634 18 .823 1, .00 74, .10 1SG1165
ATOM 1165 CD LYS 152 141 .128 23 .639 19, .980 1, .00 74, .10 1SG1166
ATOM 1166 CE LYS 152 140 .543 24 .157 21. .295 1, .00 74, .10 1SG1167
ATOM 1167 NZ LYS 152 140, .696 23 .137 22, .356 1, .00 74, .10 1SG1168
ATOM 1168 C LYS 152 139, .361 23, .333 16, .898 1, .00 74 , .10 1SG1169
ATOM 1169 O LYS 152 138 .683 23 .305 17 .927 1 .00 74 .10 1SG1170
ATOM 1170 N LEU 153 138 .837 23 .723 15 .729 1 .00 70, .43 1SG1171
ATOM 1171 CA LEU 153 137 .550 24 .354 15 .599 1 .00 70, .43 1SG1172
ATOM 1172 CB LEU 153 137, .193 24 .653 14. .134 1, .00 70, .43 1SG1173
ATOM 1173 CG LEU 153 138, .143 25 .666 13, .468 1, .00 70, .43 1SG1174
ATOM 1174 CD2 LEU 153 137, .601 26 .130 12, .107 1. .00 70, .43 1SG1175
ATOM 1175 CD1 LEU 153 139 .577 25 .116 13 .383 1 .00 70, .43 1SG1176
ATOM 1176 C LEU 153 136 .411 23 .565 16 .183 1 .00 70. .43 1SG1177
ATOM 1177 O LEU 153 135 .418 24 .176 16, .575 1, .00 70, .43 1SG1178
ATOM 1178 N CYS 154 136, .480 22, .216 16, .218 1, .00 65, .23 1SG1179
ATOM 1179 CA CYS 154 135, .371 21, .402 16, .666 1, .00 65. .23 1SG1180
ATOM 1180 CB CYS 154 135 .624 19 .898 16 .477 1 .00 65. .23 1SG1181
ATOM 1181 SG CYS 154 135 .321 19 .282 14 .798 1, .00 65. .23 1SG1182
ATOM 1182 C CYS 154 135 .019 21 .562 18 .128 1, .00 65, .23 1SG1183
ATOM 1183 O CYS 154 134, .517 20 .616 18, .732 1, .00 65. .23 1SG1184
ATOM 1184 N LEU 155 135, .226 22 .751 18. .729 1, .00 59. .26 1SG1185
ATOM 1185 CA LEU 155 134, .828 23, .048 20. .080 1. .00 59. .26 1SG1186
ATOM 1186 CB LEU 155 135 .353 24 .399 20 .585 1, .00 59. .26 1SG1187
ATOM 1187 CG LEU 155 134 .923 24 .716 22 .029 1. .00 59. .26 1SG1188
ATOM 1188 CD2 LEU 155 135 .274 26 .160 22. .413 1, .00 59. .26 1SG1189
ATOM 1189 CD1 LEU 155 135, .492 23 .685 23, .016 1, .00 59. .26 1SG1190
ATOM 1190 C LEU 155 133, .330 23, .112 20. .081 1, .00 59. .26 1SG1191
ATOM 1191 O LEU 155 132 .667 22 .857 21 .087 1, .00 59. .26 1SG1192
ATOM 1192 N SER 156 132 .769 23 .477 18 .916 1, .00 50. .84 1SG1193
ATOM 1193 CA SER 156 131, .361 23 .683 18, .753 1, .00 50. .84 1SG1194
ATOM 1194 CB SER 156 130, .977 24, .005 17, .300 1, .00 50. .84 1SG1195 ATOM 1195 OG SER 156 131..565 25..235 16..900 1..00 50..84 1SG1196
ATOM 1196 C SER 156 130. .619 22. .448 19. .143 1. .00 50. .84 1SG1197
ATOM 1197 O SER 156 129. ,462 22. .524 19. .553 1. .00 50. .84 1SG1198
ATOM 1198 N THR 157 131. .257 21. .271 19. , 041 1. .00 45. .50 1SG1199
ATOM 1199 CA THR 157 130. .548 20. .069 19. ,366 1. .00 45. .50 1SG1200
ATOM 1200 CB THR 157 131. .399 18. .838 19. .202 1. .00 45. .50 1SG1201
ATOM 1201 OGl THR 157 130. .639 17, .671 19. .476 1. .00 45. .50 1SG1202
ATOM 1202 CG2 THR 157 132. .613 18. .920 20. ,142 1. .00 45. .50 1SG1203
ATOM 1203 C THR 157 130. .083 20, .149 20. .787 1. .00 45. .50 1SG1204
ATOM 1204 O THR 157 128. .935 19. .828 21. .089 1, .00 45. ,50 1SG1205
ATOM 1205 N SER 158 130. .961 20, .596 21. .702 1. .00 40. .77 1SG1206
ATOM 1206 CA SER 158 130. .599 20. .661 23. ,087 1. ,00 40. .77 1SG1207
ATOM 1207 CB SER 158 131. .772 21. .084 23. .988 1. .00 40. .77 1SG1208
ATOM 1208 OG SER 158 132. .171 22, .411 23. .679 1. .00 40. .77 1SG1209
ATOM 1209 C SER 158 129. .506 21, .663 23. .279 1. .00 40. .77 1SG1210
ATOM 1210 O SER 158 128. .533 21. .403 23. ,985 1. .00 40. ,77 1SG1211
ATOM 1211 N ASN 159 129. .620 22 .829 22. .619 1. .00 38 .86 1SG1212
ATOM 1212 CA ASN 159 128, .682 23. .892 22. .838 1, .00 38. .86 1SG1213
ATOM 1213 CB ASN 159 128, .964 25. .125 21. .960 1. .00 38, .86 1SG1214
ATOM 1214 CG ASN 159 128, .048 26. .257 22. .407 1. .00 38, .86 1SG1215
ATOM 1215 OD1 ASN 159 126, .826 26. .119 22. .437 1 .00 38 .86 1SG1216
ATOM 1216 ND2 ASN 159 128, .658 27. .416 22. .772 1. .00 38. .86 1SG1217
ATOM 1217 C ASN 159 127, .303 23 .418 22, .520 1. .00 38. .86 1SG1218
ATOM 1218 O ASN 159 126, .352 23, .734 23. .235 1, .00 38, .86 1SG1219
ATOM 1219 N LEU 160 127, .144 22, .650 21. ,432 1. .00 38 .78 1SG1220
ATOM 1220 CA LEU 160 125, .817 22, .234 21. .091 1. .00 38, .78 1SG1221
ATOM 1221 CB LEU 160 125 .804 21 .417 19. .777 1. .00 38 .78 1SG1222
ATOM 1222 CG LEU 160 124, .427 20, .983 19. .216 1. .00 38, .78 1SG1223
ATOM 1223 CD2 LEU 160 123, .631 20, .083 20. .176 1. .00 38. .78 1SG1224
ATOM 1224 CD1 LEU 160 124 .606 20 .296 17 .852 1 .00 38 .78 1SG1225
ATOM 1225 C LEU 160 125, .289 21 .392 22. .210 1. .00 38 .78 1SG1226
ATOM 1226 O LEU 160 124, .205 21, .640 22. .735 1. .00 38. .78 1SG1227
ATOM 1227 N VAL 161 126, .061 20 .383 22. .641 1. .00 38 .58 1SG1228
ATOM 1228 CA VAL 161 125 .525 19 .507 23 .635 1 .00 38 .58 1SG1229
ATOM 1229 CB VAL 161 126 .475 18 .407 24, .008 1. .00 38 .58 1SG1230
ATOM 1230 CGI VAL 161 125 .849 17 .583 25, .146 1 .00 38 .58 1SG1231
ATOM 1231 CG2 VAL 161 126, .796 17, .588 22, .747 1. .00 38. .58 1SG1232
ATOM 1232 C VAL 161 125 .216 20 .264 24, .885 1 .00 38 .58 1SG1233
ATOM 1233 O VAL 161 124, .085 20, .223 25, .366 1. .00 38. .58 1SG1234
ATOM 1234 N GLN 162 126 .204 20 .970 25, .468 1 .00 39 .98 1SG1235
ATOM 1235 CA GLN 162 125, .853 21, .598 26, ,706 1, .00 39. .98 1SG1236
ATOM 1236 CB GLN 162 127. .046 22, .103 27, .546 1 .00 39 .98 1SG1237
ATOM 1237 CG GLN 162 127 .830 23 .269 26 .938 1 .00 39 .98 1SG1238
ATOM 1238 CD GLN 162 129 .103 22 .721 26, .315 1, .00 39, .98 1SG1239
ATOM 1239 OEl GLN 162 129, .853 23, .446 25. ,663 1, .00 39, .98 1SG1240
ATOM 1240 NE2 GLN 162 129 .358 21, .401 26. .519 1 .00 39 .98 1SG1241
ATOM 1241 C GLN 162 124 .944 22 .773 26. .514 1 .00 39 .98 1SG1242
ATOM 1242 O GLN 162 123 .905 22, .857 27, .163 1, .00 39, .98 1SG1243
ATOM 1243 N GLY 163 125 .348 23 .735 25, .656 1 .00 38 .85 1SG1244
ATOM 1244 CA GLY 163 124, .623 24, .968 25, .479 1, .00 38, .85 1SG1245
ATOM 1245 C GLY 163 123 .381 24 .941 24, .634 1 .00 38 .85 1SG1246
ATOM 1246 O GLY 163 122, .334 25, .424 25 .063 1, .00 38, .85 1SG1247
ATOM 1247 N VAL 164 123 .467 24 .421 23, .390 1 .00 37, .42 1SG1248
ATOM 1248 CA VAL 164 122, .340 24, .582 22. .508 1, .00 37. .42 1SG1249
ATOM 1249 CB VAL 164 122, .626 24, .321 21, .051 1, .00 37, .42 1SG1250
ATOM 1250 CGI VAL 164 122 .697 22 .813 20, .784 1 .00 37 .42 1SG1251
ATOM 1251 CG2 VAL 164 121, .544 25, .035 20. ,223 1, .00 37, .42 1SG1252 ATOM 1252 C VAL 164 121.173 23..743 22.,914 1.00 37.42 1SG1253
ATOM 1253 o VAL 164 120. 036 24. 212 22. .907 1. ,00 37. 42 1SG1254
ATOM 1254 N ASN 165 121. 422 22. .475 23. .284 1. 00 35. 82 1SG1255
ATOM 1255 CA ASN 165 120. 349 21. .576 23. .595 1. 00 35. 82 1SG1256
ATOM 1256 CB ASN 165 120. .845 20. .163 23. ,953 1. 00 35. 82 1SG1257
ATOM 1257 CG ASN 165 119. 643 19. .230 24. .023 1. ,00 35. .82 1SG1258
ATOM 1258 OD1 ASN 165 118. .648 19. ,513 24. .688 1. ,00 35. 82 1SG1259
ATOM 1259 ND2 ASN 165 119. .734 18. ,078 23. .306 1. .00 35. .82 1SG1260
ATOM 1260 C ASN 165 119. 577 22. .094 24. .766 1. ,00 35. 82 1SG1261
ATOM 1261 O ASN 165 118. ,348 22. ,087 24. .762 1. .00 35. .82 1SG1262
ATOM 1262 N VAL 166 120. ,284 22. ,576 25. .800 1. .00 34. ,62 1SG1263
ATOM 1263 CA VAL 166 119. .647 23. ,031 27. ,001 1. .00 34. .62 1SG1264
ATOM 1264 CB VAL 166 120. .622 23. .481 28. .050 1. ,00 34. .62 1SG1265
ATOM 1265 CGI VAL 166 121. .362 24. .725 27. .532 1. .00 34. .62 1SG1266
ATOM 1266 CG2 VAL 166 119. ,853 23. .719 29. .360 1. .00 34. .62 1SG1267
ATOM 1267 C VAL 166 118. .752 24. .190 26. .695 1. .00 34. .62 1SG1268
ATOM 1268 O VAL 166 117. .685 24. .323 27. .289 1. .00 34. .62 1SG1269
ATOM 1269 N HIS 167 119. .173 25. .077 25. .774 1. .00 34. .74 1SG1270
ATOM 1270 CA HIS 167 118. ,410 26. ,254 25. .464 1, .00 34. .74 1SG1271
ATOM 1271 ND1 HIS 167 117. .353 28. .535 23. .241 1. .00 34. .74 1SG1272
ATOM 1272 CG HIS 167 118. .363 28. ,435 24. .172 1. .00 34, .74 1SG1273
ATOM 1273 CB HIS 167 119. .122 27. .173 24. .457 1. .00 34. .74 1SG1274
ATOM 1274 NE2 HIS 167 117. .572 30. ,548 24. .159 1, .00 34, .74 1SG1275
ATOM 1275 CD2 HIS 167 118. .483 29. .674 24, .724 1. .00 34. .74 1SG1276
ATOM 1276 CE1 HIS 167 116. .916 29. .819 23, .274 1. .00 34. .74 1SG1277
ATOM 1277 C HIS 167 117, .082 25. .880 24, .869 1, .00 34. .74 1SG1278
ATOM 1278 O HIS 167 116, .048 26. .422 25, .251 1. .00 34. .74 1SG1279
ATOM 1279 N LEU 168 117, .081 24, .925 23, .924 1, .00 38, .32 1SG1280
ATOM 1280 CA LEU 168 115, .908 24, .491 23, .216 1, .00 38 .32 1SG1281
ATOM 1281 CB LEU 168 116. .222 23, .475 22, .105 1, .00 38, .32 1SG1282
ATOM 1282 CG LEU 168 117, .094 24, .061 20, .978 1 .00 38 .32 1SG1283
ATOM 1283 CD2 LEU 168 116. .487 25 .358 20, .417 1, .00 38 .32 1SG1284
ATOM 1284 CD1 LEU 168 117, .380 23 , .017 19, .889 1 .00 38 .32 1SG1285
ATOM 1285 C LEU 168 114, .959 23 .841 24 .175 1, .00 38 .32 1SG1286
ATOM 1286 O LEU 168 113, .766 23, .728 23, .908 1 .00 38 .32 1SG1287
ATOM 1287 N GLY 169 115, .491 23 .333 25 .293 1 .00 47 .29 1SG1288
ATOM 1288 CA GLY 169 114, .763 22, .672 26, .338 1, .00 47 .29 1SG1289
ATOM 1289 C GLY 169 113, .823 23 .638 26 .988 1 .00 47 .29 1SG1290
ATOM 1290 O GLY 169 112 .883 23 .229 27, .666 1, .00 47 .29 1SG1291
ATOM 1291 N THR 170 114, .103 24, .946 26 .852 1 .00 57 .47 1SG1292
ATOM 1292 CA THR 170 113 .355 26, .002 27 .472 1 .00 57 .47 1SG1293
ATOM 1293 CB THR 170 113, .911 27. .372 27 .205 1 .00 57 .47 1SG1294
ATOM 1294 OGl THR 170 113 .860 27 .667 25 .817 1 .00 57 .47 1SG1295
ATOM 1295 CG2 THR 170 115, .362 27. .423 27 .713 1 .00 57 .47 1SG1296
ATOM 1296 C THR 170 111 .938 25 .985 26 .990 1 .00 57 .47 1SG1297
ATOM 1297 O THR 170 111, .065 26. .525 27 .668 1 .00 57 .47 1SG1298
ATOM 1298 N LEU 171 111 .672 25 .400 25 .800 1 .00 69 .26 1SG1299
ATOM 1299 CA LEU 171 110 .330 25. .363 25 .279 1 .00 69 .26 1SG1300
ATOM 1300 CB LEU 171 110, .100 24 .475 24 .042 1 .00 69 .26 1SG1301
ATOM 1301 CG LEU 171 110 .496 25. .103 2 .699 1 .00 69 .26 1SG1302
ATOM 1302 CD2 LEU 171 109, .975 24 .264 21 .521 1 .00 69 .26 1SG1303
ATOM 1303 CD1 LEU 171 111 .999 25, .366 22 .615 1 .00 69 .26 1SG1304
ATOM 1304 C LEU 171 109. .381 24 .847 26 .316 1 .00 69 .26 1SG1305
ATOM 1305 O LEU 171 10 .723 24, .025 27 .166 1 .00 69 .26 1SG1306
ATOM 1306 N ILE 172 108 .134 25 .351 26 .226 1 .00 76 .91 1SG1307
ATOM 1307 CA ILE 172 107 .102 25, .185 27 .208 1 .00 76 .91 1SG1308
ATOM 1308 CB ILE 172 105 .840 25. .893 26 .817 1 .00 76 .91 1SG1309 ATOM 1309 CG2 ILE 172 104..757 25..510 27..836 1.00 76..91 1SG1310
ATOM 1310 CGI ILE 172 106. .081 27. .408 26. .710 1. ,00 76. .91 1SG1311
ATOM 1311 CD1 ILE 172 106. .536 28. .042 28. .024 1. ,00 76. .91 1SG1312
ATOM 1312 C ILE 172 106. .718 23. .769 27. .522 1. ,00 76. .91 1SG1313
ATOM 1313 O ILE 172 106, .699 23. .420 28. .679 1. .00 76. .91 1SG1314
ATOM 1314 N GLY 173 106, .398 22. .844 26. .621 1. .00 74. .76 1SG1315
ATOM 1315 CA GLY 173 106 , .069 21. .572 27. .238 1. .00 74. .76 1SG1316
ATOM 1316 C GLY 173 104. .747 21. ,653 27. .964 1. ,00 74. ,76 1SG1317
ATOM 1317 O GLY 173 103. .701 21. .736 27, .333 1. .00 74. .76 1SG1318
ATOM 1318 N LEU 174 104, .733 21. .573 29, .315 1. .00 69. .28 1SG1319
ATOM 1319 CA LEU 174 103. .477 21. .666 30. .013 1. .00 69. .28 1SG1320
ATOM 1320 CB LEU 174 103. .314 20. .620 31. .127 1. .00 69. .28 1SG1321
ATOM 1321 CG LEU 174 103. .241 19, .174 30. .605 1. .00 69. .28 1SG1322
ATOM 1322 CD2 LEU 174 102, .828 18. .201 31. .722 1. .00 69. .28 1SG1323
ATOM 1323 CD1 LEU 174 104. .546 18. .763 29. .904 1. .00 69. .28 1SG1324
ATOM 1324 C LEU 174 103. .410 23, .011 30. .659 1. .00 69. .28 1SG1325
ATOM 1325 O LEU 174 104. .077 23, .262 31. .662 1. .00 69, .28 1SG1326
ATOM 1326 N ASN 175 102. .578 23. .920 30. .113 1. .00 59, .55 1SG1327
ATOM 1327 CA ASN 175 102, .534 25. .219 30. .713 1. .00 59, .55 1SG1328
ATOM 1328 CB ASN 175 102. .657 26, .383 29. .710 1. .00 59, .55 1SG1329
ATOM 1329 CG ASN 175 101, .516 26, .304 28, .709 1. .00 59, .55 1SG1330
ATOM 1330 OD1 ASN 175 100, .577 27. .096 28, .752 1. .00 59, .55 1SG1331
ATOM 1331 ND2 ASN 175 101 .605 25, .322 27, .771 1, .00 59, .55 1SG1332
ATOM 1332 C ASN 175 101, .247 25, .377 31, .456 1. .00 59. .55 1SG1333
ATOM 1333 O ASN 175 100. .161 25. .313 30. .880 1. .00 59. .55 1SG1334
ATOM 1334 N PRO 176 101 .360 25. .514 32 .753 1. .00 50. .83 1SG1335
ATOM 1335 CA PRO 176 100. .187 25. .772 33. .541 1, .00 50. .83 1SG1336
ATOM 1336 CD PRO 176 102, .333 24. .718 33. .483 1. .00 50. .83 1SG1337
ATOM 1337 CB PRO 176 100, .539 25 .386 34, .976 1, .00 50. .83 1SG1338
ATOM 1338 CG PRO 176 101, .646 24. .333 34 .804 1, .00 50. .83 1SG1339
ATOM 1339 C PRO 176 99, .768 27. .201 33 , .394 1. .00 50. .83 1SG1340
ATOM 1340 O PRO 176 100, .588 28. .082 33, .654 1. .00 50. .83 1SG1341
ATOM 1341 N VAL 177 98 .516 27 .450 32 .964 1, .00 45. .94 1SG1342
ATOM 1342 CA VAL 177 97, .975 28, .775 32, .846 1. .00 45. .94 1SG1343
ATOM 1343 CB VAL 177 96, .792 28, .834 31, .922 1. .00 45, .94 1SG1344
ATOM 1344 CGI VAL 177 95, .667 27 .955 32, .494 1, .00 45, .94 1SG1345
ATOM 1345 CG2 VAL 177 96, .395 30, .308 31, .733 1. .00 45. .94 1SG1346
ATOM 1346 C VAL 177 97, .542 29, .297 34, .180 1. .00 45. .94 1SG1347
ATOM 1347 O VAL 177 97, .750 30, .467 34, .498 1. .00 45. .94 1SG1348
ATOM 1348 N GLY 178 96, .905 28, .425 34, .989 1, .00 42. .04 1SG1349
ATOM 1349 CA GLY 178 96, .369 28, .830 36. .256 1. .00 42, .04 1SG1350
ATOM 1350 C GLY 178 95, .990 27, .585 36. .988 1. .00 42. .04 1SG1351
ATOM 1351 O GLY 178 96 .351 26 .480 36 .593 1, .00 42. .04 1SG1352
ATOM 1352 N PRO 179 95, .285 27, .739 38, .068 1, .00 40. .83 1SG1353
ATOM 1353 CA PRO 179 94, .897 26, .616 38, .871 1. .00 40. .83 1SG1354
ATOM 1354 CD PRO 179 94, .415 28, .886 38, .268 1. .00 40. .83 1SG1355
ATOM 1355 CB PRO 179 93, .990 27, .195 39. .954 1. .00 40. .83 1SG1356
ATOM 1356 CG PRO 179 93. .333 28, .395 39, .246 1. .00 40. .83 1SG1357
ATOM 1357 C PRO 179 94. .171 25, .563 38, .083 1. .00 40. .83 1SG1358
ATOM 1358 O PRO 179 94. .393 24 .383 38, .351 1. .00 40. .83 1SG1359
ATOM 1359 N GLU 180 93. .249 25, .956 37, .177 1. .00 39. .11 1SG1360
ATOM 1360 CA GLU 180 92, .447 25, .000 36. .462 1. .00 39. .11 1SG1361
ATOM 1361 CB GLU 180 91. .222 25. .663 35. .811 1. .00 39. ,11 1SG1362
ATOM 1362 CG GLU 180 90, .254 26. .280 36. .824 1. .00 39. .11 1SG1363
ATOM 1363 CD GLU 180 89, .547 25. .150 37. .556 1. .00 39. .11 1SG1364
ATOM 1364 OEl GLU 180 89. .656 23. .984 37. .089 1. .00 39. .11 1SG1365
ATOM 1365 OE2 GLU 180 88. .886 25. .436 38, .589 1. .00 39. .11 1SG1366 ATOM 1366 C GLU 180 93..157 24..243 35..369 1..00 39..11 1SG1367
ATOM 1367 O GLU 180 93. ,258 23. .019 35. .424 1. ,00 39. ,11 1SG1368
ATOM 1368 N SER 181 93. ,718 24, .942 34. .359 1. .00 38. .93 1SG1369
ATOM 1369 CA SER 181 94. ,189 24. .206 33. .216 1. .00 38. .93 1SG1370
ATOM 1370 CB SER 181 93. .362 24. .475 31. .948 1. .00 38. .93 1SG1371
ATOM 1371 OG SER 181 93. .500 25. .834 31. .559 1. .00 38. .93 1SG1372
ATOM 1372 C SER 181 95. .605 24. .534 32. .872 1. .00 38. .93 1SG1373
ATOM 1373 O SER 181 96, .221 25. .431 33. .443 1. .00 38. .93 1SG1374
ATOM 1374 N GLN 182 96. .149 23. .747 31. .916 1. .00 40. .50 1SG1375
ATOM 1375 CA GLN 182 97. .484 23, .894 31. .418 1. .00 40. .50 1SG1376
ATOM 1376 CB GLN 182 98. .495 22, .917 32 .043 1, .00 40. .50 1SG1377
ATOM 1377 CG GLN 182 98. .725 23, .140 33, .538 1. .00 40. .50 1SG1378
ATOM 1378 CD GLN 182 99. .740 22. .106 34, .006 1. .00 40. .50 1SG1379
ATOM 1379 OEl GLN 182 100. .780 21, .911 33. .382 1. .00 40. .50 1SG1380
ATOM 1380 NE2 GLN 182 99. .426 21, .418 35. .136 1, .00 40, .50 1SG1381
ATOM 1381 C GLN 182 97, .424 23 .575 29 .958 1, .00 40, .50 1SG1382
ATOM 1382 O GLN 182 96. .394 23. .132 29. .453 1. .00 40, .50 1SG1383
ATOM 1383 N ILE 183 98. .536 23. .810 29. .234 1. .00 43, .62 1SG1384
ATOM 1384 CA ILE 183 98. .552 23. .537 27. .829 1, .00 43, .62 1SG1385
ATOM 1385 CB ILE 183 98. .905 24 .734 27 .005 1. .00 43 .62 1SG1386
ATOM 1386 CG2 ILE 183 98. .818 24. .330 25. .525 1 .00 4 .62 1SG1387
ATOM 1387 CGI ILE 183 98. .010 25. .926 27, .355 1. .00 43. .62 1SG1388
ATOM 1388 CD1 ILE 183 98. .557 27, .236 26, .803 1. .00 43, .62 1SG1389
ATOM 1389 C ILE 183 99. .664 22 .567 27 .595 1, .00 43, .62 1SG1390
ATOM 1390 O ILE 183 100. .718 22, .655 28 .222 1. .00 43 .62 1SG1391
ATOM 1391 N ARG 184 99, .456 21, .596 26 .688 1, .00 48, .74 1SG1392
ATOM 1392 CA ARG 184 100. .507 20, .663 26, .417 1. .00 48, .74 1SG1393
ATOM 1393 CB ARG 184 100. .036 19, .204 26 .299 1. .00 48, .74 1SG1394
ATOM 1394 CG ARG 184 101, .180 18 .229 26 .010 1. .00 48 .74 1SG1395
ATOM 1395 CD ARG 184 100. .724 16, .804 25 .683 1. .00 48, .74 1SG1396
ATOM 1396 NE ARG 184 100. .091 16 .240 26 .908 1. .00 48, .74 1SG1397
ATOM 1397 CZ ARG 184 99. .696 14, .933 26, .932 1. .00 48, .74 1SG1398
ATOM 1398 NH1 ARG 184 99. .897 14, .135 25 .843 1. .00 48, .74 1SG1399
ATOM 1399 NH2 ARG 184 99. .100 14, .423 28, .050 1. .00 48, .74 1SG1400
ATOM 1400 C ARG 184 101, .114 21, .019 25 .100 1, .00 48, .74 1SG1401
ATOM 1401 O ARG 184 100, .488 20 .844 24 .056 1, .00 48 .74 1SG1402
ATOM 1402 N TYR 185 102, .362 21 .535 25 .118 1, .00 53, .28 1SG1403
ATOM 1403 CA TYR 185 103. .037 21. .847 23, .894 1. .00 53, .28 1SG1404
ATOM 1404 CB TYR 185 103. .795 23, .189 23, .906 1. .00 53, .28 1SG1405
ATOM 1405 CG TYR 185 102. .846 24 .337 23 .862 1, .00 53, .28 1SG1406
ATOM 1406 CD1 TYR 185 102, .140 24 .608 22 .712 1, .00 53 .28 1SG1407
ATOM 1407 CD2 TYR 185 102. .692 25, .168 24, .948 1. .00 53 .28 1SG1408
ATOM 1408 CE1 TYR 185 101. .275 25, .675 22, .651 1. .00 53. .28 1SG1409
ATOM 1409 CE2 TYR 185 101, .828 26, .237 24, .893 1. .00 53. .28 1SG1410
ATOM 1410 CZ TYR 185 101, .116 26, .490 23 .745 1, .00 53. .28 1SG1411
ATOM 1411 OH TYR 185 100, .230 27, .587 23 .687 1. .00 53. .28 1SG1412
ATOM 1412 C TYR 185 104, .096 20, .809 23 .670 1. .00 53. .28 1SG1413
ATOM 1413 O TYR 185 105, .168 21, .107 23, .147 1. .00 53. .28 1SG1414
ATOM 1414 N SER 186 103, .802 19, .542 24, .003 1. .00 55. .61 1SG1415
ATOM 1415 CA SER 186 104. .776 18 .499 23 .833 1, .00 55. .61 1SG1416
ATOM 1416 CB SER 186 104. .391 17, .180 24, .521 1. .00 55. .61 1SG1417
ATOM 1417 OG SER 186 105, .313 16. .165 24, .155 1. .00 55. .61 1SG1418
ATOM 1418 C SER 186 104 , .933 18, .187 22, .383 1. .00 55. .61 1SG1419
ATOM 1419 O SER 186 103, .968 18, .168 21, .622 1. .00 55. .61 1SG1420
ATOM 1420 N MET 187 106. .184 17, .910 21. .968 1. .00 55, .40 1SG1421
ATOM 1421 CA MET 187 106. .434 17, .585 20. .596 1. .00 55, .40 1SG1422
ATOM 1422 CB MET 187 107, .896 17, .833 20, .203 1. .00 55. .40 1SG1423 HH CCNN Λ ^ ιn vo [^ oo c θ r^ r- r- r- t-~ r~ [^ r-
C_ C5 CD C_ C. CD C_ O C. C_ w w w -. w w c/_ w w __
σι σι σι σι _. σv o o o o
Figure imgf000189_0001
in m in in in in σi σi σi σi ιn ιn ιn m ιn cn ro ro n m n n oo oo co oo co oo ιn ιn ιn ιn ιn ιn ιn ^' ^. )< i< *!* ^i *3* -p -. ^ ^ ^■ u i i io io vD D Vo vo o o o o o o o n m m r i i in in in i m in in in in m 'j '. ^ 'j f i' ^ '. ^ ^ 'j 'f ^ '. ^ i1 '!' -p -p ^J* -fl ^ ^ <f ^ ^ rf ^ ^ <f ^ ιf ^ ιn ιn ιn ιn ιn ιn ιn ιn ι ι ιn o o o ooo o o ooo o o o oo o o oo oo o o o o o oo o oo ooo oo o o o oo oo oo oo o o o o oo o ooo o o o o o o o oo ooo oo o o o o oo o oo ooo oo ooo o o ooo o oo oo oo o o o o o o o o
H H H H H H H H o o t-- C H rn H σι vD σι rN iN in σι in H r~ n ιn H o cN CN in io in r H ro. rι^^ oo moo r^ iιrni oo ^^r, vo ιn n (N CN H CN M θ (vι crι H iιno iΛ «) iD r- ιn oi i ι|i H B)
O O O O H o. co co σ
Figure imgf000189_0002
> vo oo vo in m vo vo in m in vo i, K n K n m -f VD CN N H θ rι co σ. σι r ιi' CN H θ o CN CN CN CN CN -. r-i H -. H H H H H H H H H H H vo H i -- n
Figure imgf000189_0003
f
Λ Λ ri i. Ki in O O O O CN H H H CN CN H
Figure imgf000189_0004
CN CN CN CN CN CN CN CN CN CN CN 00 -p in o ιn _- ιo ro .~ ro o H n in vo H o ^ r^ r^ H CD in cΛ r M in in i o oo cτι σι H σι co oo cN θ in σι CN in r~ σ\ o o ,-, H π C_Ti. r .-- H OO VO CN VD t O in N H ri in H c^ r^ o o o σi cN vo m rji o vo i' σi cN O ^ H rn cN H in o vD M' o r- H C i p- n ^ σi vo m M r vD o cN ^' O H oo r-i m c oo CN O I- O -. H in n N io in ^ if cN r^ in in in vo oo σi H in r- oo in ^ O f CN oo r~ O rn o ^ cN cn in cri p~ H iN cn cN H co n cn ^' co cN CN Co vo oo o cn vD vo in ^ m cN rn in in vo r- vD in oo oo cri o H CN o σι H H CN CN CN H CN H H O O Ol H N n i in in n i cN O O o n -ai CN n m n
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H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H
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H H H H H H H H H H H H H H
Figure imgf000189_0005
H ^ H H H J J J J J J J « « « 05 « rt J J h. J J h5 J O O O O O O O « « « « « C. P5 J J J J J J J ω a w w a ft f£ ft >< fi ft a w a a a a ft ϊt oi Pi oi Qi K Di κ x x x x x x x ft ε ε > > > > > > > w w w w w w > > > > > > > cu ft ft ft (-. < ei( H E-ι EH H EH H > > > > > > > EH H H H E-ι H w w ω
H CN H CN H CN H CN H CN
CD Q ω ft PQ CD < CQ CD CD t P PQ CD ft PQ CD C PQ CD CD < m CD CD PQ CD uD CuD u pauupuoauuuuu p a u u u u u p a u u p uD u p a U U U U U O a U U P u u
90 u ω u u p a u ft uPQ C p a u u p r- r. 'S' in io t- oo σi O H CN r'i ^ in vo r- co σι o H CN d n« ιn vo r- co σi o H CN n '^' in vo c- oo σi O H CN ro q' in vo c^ oo σi o H CN n ^ in vo r- oo o c CN CN iN CN CN CN n r n n r n n <* in in in in in in in in in in io io vD VD io vo vo vo vo vo r- t- r- [^ r- r- t^ r~ r-- t-
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Figure imgf000189_0006
ATOM 1480 C SER 195 113..651 23,.853 2..429 1..00 53..90 1SG1481
ATOM 1481 O SER 195 114. .708 24 , .379 2. .773 1. .00 53. .90 1SG1482
ATOM 1482 N ASP 196 112. .461 24, .472 2 , .543 1. .00 55. .77 1SG1483
ATOM 1483 CA ASP 196 112. .268 25, .791 3. .080 1. .00 55. .77 1SG1484
ATOM 1484 CB ASP 196 111. .024 26, .474 2. .490 1. .00 55. .77 1SG1485
ATOM 1485 CG ASP 196 111. .332 26, .784 1, .032 1. .00 55. .77 1SG1486
ATOM 1486 OD1 ASP 196 112. .542 26. .841 0. .684 1. .00 55, .77 1SG1487
ATOM 1487 OD2 ASP 196 110. .364 26. .967 0. .246 1. .00 55, .77 1SG1488
ATOM 1488 C ASP 196 112. .171 25. .919 4. .579 1. .00 55, .77 1SG1489
ATOM 1489 O ASP 196 112. .577 26. .945 5. .124 1. .00 55, .77 1SG1490
ATOM 1490 N TYR 197 111. .594 24. .930 5. .296 1. .00 56, .72 1SG1491
ATOM 1491 CA TYR 197 Ill, .290 25. .190 6, .680 1, .00 56, .72 1SG1492
ATOM 1492 CB TYR 197 109, .779 25, .381 6, .893 1, .00 56 .72 1SG1493
ATOM 1493 CG TYR 197 109, .118 24, .168 6, .324 1, .00 56 .72 1SG1494
ATOM 1494 CD1 TYR 197 109. .009 22, .996 7, .039 1, .00 56 .72 1SG1495
ATOM 1495 CD2 TYR 197 108. .604 24 .206 5, .050 1, .00 56 .72 1SG1496
ATOM 1496 CE1 TYR 197 108, .397 21 .893 6, .487 1, .00 56 .72 1SG1497
ATOM 1497 CE2 TYR 197 107, .990 23, .109 4, .493 1. .00 56 .72 1SG1498
ATOM 1498 CZ TYR 197 107. .889 21, .945 5, .213 1, .00 56 .72 1SG1499
ATOM 1499 OH TYR 197 107. .263 20, .811 4, .651 1, .00 56 .72 1SG1500
ATOM 1500 C TYR 197 111. .688 24, .081 7, .605 1, .00 56 .72 1SG1501
ATOM 1501 O TYR 197 111. .960 22. .951 7, .205 1, .00 56 .72 1SG1502
ATOM 1502 N ILE 198 111. .720 24, .407 8, .914 1, .00 53 .50 1SG1503
ATOM 1503 CA ILE 198 111. .961 23, .400 9, .901 1, .00 53 .50 1SG1504
ATOM 1504 CB ILE 198 112. .992 23, .784 10, .940 1, .00 53. .50 1SG1505
ATOM 1505 CG2 ILE 198 114. .262 24, .186 10, .175 1, .00 53 .50 1SG1506
ATOM 1506 CGI ILE 198 112. .528 24, .894 11. .899 1, .00 53 .50 1SG1507
ATOM 1507 CD1 ILE 198 111. .727 24 .395 13 .104 1 .00 53 .50 1SG1508
ATOM 1508 C ILE 198 110, .616 23 .260 10 .541 1 .00 53 .50 1SG1509
ATOM 1509 0 ILE 198 110, .024 24 .244 10 .979 1 .00 53 .50 1SG1510
ATOM 1510 N SER 199 110. .053 22 .040 10 .562 1 .00 48 .23 1SG1511
ATOM 1511 CA SER 199 108. .731 21 .937 11 .101 1 .00 48 .23 1SG1512
ATOM 1512 CB SER 199 107, .748 21 .151 10 .220 1, .00 48 .23 1SG1513
ATOM 1513 OG SER 199 107, .397 21 .919 9 .080 1, .00 48 .23 1SG1514
ATOM 1514 C SER 199 108, .765 21, .255 12 .425 1 .00 48 .23 1SG1515
ATOM 1515 0 SER 199 109, .452 20 .252 12, .615 1 .00 48 .23 1SG1516
ATOM 1516 N LEU 200 108, .002 21, .815 13, .386 1, .00 44 .14 1SG1517
ATOM 1517 CA LEU 200 107, .912 21, .240 14 .697 1, .00 44 .14 1SG1518
ATOM 1518 CB LEU 200 108, .397 22, .182 15, .811 1, .00 44 .14 1SG1519
ATOM 1519 CG LEU 200 109, .888 22, .557 15. .695 1, .00 44, .14 1SG1520
ATOM 1520 CD2 LEU 200 110. .769 21, .301 15. .600 1, .00 44, .14 1SG1521
ATOM 1521 CD1 LEU 200 110. .318 23, .493 16. .835 1, .00 44. .14 1SG1522
ATOM 1522 C LEU 200 106. .465 20 .955 14 .955 1 .00 44 .14 1SG1523
ATOM 1523 0 LEU 200 105. .608 21 .824 14 .792 1 .00 44 .14 1SG1524
ATOM 1524 N GLU 201 106. .155 19 .714 15 .376 1 .00 38 .88 1SG1525
ATOM 1525 CA GLU 201 104, .794 19, .333 15 .624 1, .00 38 .88 1SG1526
ATOM 1526 CB GLU 201 104, .445 17 .964 15 .013 1, .00 38 .88 1SG1527
ATOM 1527 CG GLU 201 104, .515 17, .964 13 .482 1, .00 38 .88 1SG1528
ATOM 1528 CD GLU 201 104, .230 16, .558 12 .971 1, .00 38. .88 1SG1529
ATOM 1529 OEl GLU 201 103, .264 15, .924 13 .473 1, .00 38. .88 1SG1530
ATOM 1530 OE2 GLU 201 104, .980 16, .099 12. .069 1, .00 38, .88 1SG1531
ATOM 1531 C GLU 201 104. .609 19, .246 17. .109 1, .00 38. .88 1SG1532
ATOM 1532 0 GLU 201 105. .404 18, .625 17. .812 1, .00 38. .88 1SG1533
ATOM 1533 N VAL 202 103. .537 19. .887 17, .617 1, .00 36. .23 1SG1534
ATOM 1534 CA VAL 202 103. .261 19, .921 19, .022 1, .00 36, .23 1SG1535
ATOM 1535 CB VAL 202 103. .346 21. .318 19. .554 1. .00 36, .23 1SG1536
ATOM 1536 CGI VAL 202 102. ,895 21. .316 21. .015 1. .00 36 , .23 1SG1537 ATOM 1537 CG2 VAL 202 104..780 21,.832 19..341 1..00 36..23 1SG1538
ATOM 1538 C VAL 202 101. .859 19, .421 19. .241 1. .00 36. .23 1SG1539
ATOM 1539 O VAL 202 101. .026 19. .475 18. .338 1. .00 36. ,23 1SG1540
ATOM 1540 N ASN 203 101, .576 18, .886 20. .454 1. .00 35. .53 1SG1541
ATOM 1541 CA ASN 203 100. .279 18, .342 20. .781 1. .00 35. .53 1SG1542
ATOM 1542 CB ASN 203 100. .246 17, .663 22. .162 1. .00 35. .53 1SG1543
ATOM 1543 CG ASN 203 101, .025 16, .359 22. .072 1. .00 35. .53 1SG1544
ATOM 1544 OD1 ASN 203 102. .070 16, .199 22. .699 1. .00 35. .53 1SG1545
ATOM 1545 ND2 ASN 203 100. .502 15. .395 21. .266 1. .00 35. .53 1SG1546
ATOM 1546 C ASN 203 99, .229 19. .421 20. .788 1, .00 35. .53 1SG1547
ATOM 1547 O ASN 203 98, .160 19, .254 20, .201 1. .00 35, .53 1SG1548
ATOM 1548 N ALA 204 99. .520 20, .570 21. .435 1. .00 34. .81 1SG1549
ATOM 1549 CA ALA 204 98. .621 21. .698 21. .490 1. .00 34. .81 1SG1550
ATOM 1550 CB ALA 204 98, .512 22. .454 20, .154 1. .00 34. .81 1SG1551
ATOM 1551 C ALA 204 97. .229 21, .363 21, .940 1. .00 34. .81 1SG1552
ATOM 1552 O ALA 204 96. .264 21, .567 21. .202 1. .00 34. .81 1SG1553
ATOM 1553 N VAL 205 97, .082 20, .843 23. .176 1, .00 36, .23 1SG1554
ATOM 1554 CA VAL 205 95, .760 20, .611 23 , .690 1, .00 36, .23 1SG1555
ATOM 1555 CB VAL 205 95. .364 19, .163 23. .704 1. .00 36. .23 1SG1556
ATOM 1556 CGI VAL 205 93. .974 19 .046 24. .353 1. .00 36 .23 1SG1557
ATOM 1557 CG2 VAL 205 95, .432 18 .615 22. .270 1. .00 36. .23 1SG1558
ATOM 1558 C VAL 205 95, .768 21, .059 25. .114 1. .00 36, .23 1SG1559
ATOM 1559 O VAL 205 96, .715 20 .786 25. .850 1. .00 36 .23 1SG1560
ATOM 1560 N LEU 206 94, .714 21, .771 25, .558 1, .00 38, .75 1SG1561
ATOM 1561 CA LEU 206 94, .731 22, .135 26, .942 1, .00 38, .75 1SG1562
ATOM 1562 CB LEU 206 93. .730 23 , .220 27. .363 1. .00 38, .75 1SG1563
ATOM 1563 CG LEU 206 93. .931 24 .583 26. .675 1. .00 38 .75 1SG1564
ATOM 1564 CD2 LEU 206 95, .410 24, .899 26, .427 1, .00 38, .75 1SG1565
ATOM 1565 CD1 LEU 206 93 , .186 25, .691 27, .439 1. .00 38, .75 1SG1566
ATOM 1566 C LEU 206 94, .378 20 .895 27 .680 1, .00 38 .75 1SG1567
ATOM 1567 O LEU 206 93, .576 20, .096 27, .198 1, .00 38 .75 1SG1568
ATOM 1568 N PHE 207 94, .968 20, .691 28, .876 1, .00 40, .12 1SG1569
ATOM 1569 CA PHE 207 94, .614 19 .532 29 .646 1 .00 40 .12 1SG1570
ATOM 1570 CB PHE 207 95, .689 18 .427 29, .679 1, .00 40, .12 1SG1571
ATOM 1571 CG PHE 207 96. .907 18, .914 30, .378 1. .00 40, .12 1SG1572
ATOM 1572 CD1 PHE 207 97 .029 18 .782 31 .742 1, .00 40 .12 1SG1573
ATOM 1573 CD2 PHE 207 97, .934 19 .489 29, .662 1, .00 40, .12 1SG1574
ATOM 1574 CE1 PHE 207 98, .159 19, .229 32, .383 1, .00 40, .12 1SG1575
ATOM 1575 CE2 PHE 207 99. .063 19, .936 30, .302 1, .00 40, .12 1SG1576
ATOM 1576 CZ PHE 207 99. .182 19 .806 31 .664 1, .00 40 .12 1SG1577
ATOM 1577 C PHE 207 94. .280 19. .975 31, .042 1, .00 40, .12 1SG1578
ATOM 1578 O PHE 207 94. .553 21, .113 31, .423 1, .00 40, .12 1SG1579
ATOM 1579 N LEU 208 93. .605 19 .105 31 .820 1, .00 41, .05 1SG1580
ATOM 1580 CA LEU 208 93, .165 19, .511 33, .123 1, .00 41, .05 1SG1581
ATOM 1581 CB LEU 208 91. .621 19, .416 33. .239 1. .00 41. .05 1SG1582
ATOM 1582 CG LEU 208 90, .958 20 .226 34. .372 1. .00 41. .05 1SG1583
ATOM 1583 CD2 LEU 208 91, .181 21, .735 34. .171 1, .00 41. .05 1SG1584
ATOM 1584 CD1 LEU 208 91. .360 19, .726 35, .759 1. .00 41. .05 1SG1585
ATOM 1585 C LEU 208 93. .823 18 .577 34, .094 1. .00 41. .05 1SG1586
ATOM 1586 O LEU 208 93. .913 17, .376 33, .848 1, .00 41. .05 1SG1587
ATOM 1587 N LEU 209 94, .361 19, .124 35, .200 1. .00 41. .00 1SG1588
ATOM 1588 CA LEU 209 95. .050 18 .362 36. .207 1, .00 41, .00 1SG1589
ATOM 1589 CB LEU 209 95, .754 19, .285 37, .217 1, .00 41, .00 1SG1590
ATOM 1590 CG LEU 209 96. .496 18, .542 38. .342 1. .00 41. .00 1SG1591
ATOM 1591 CD2 LEU 209 96. .999 19. .527 39. .412 1. .00 41. .00 1SG1592
ATOM 1592 CD1 LEU 209 97. .612 17. .640 37. .788 1. .00 41, .00 1SG1593
ATOM 1593 C LEU 209 94. .108 17. .472 36. .968 1. .00 41. .00 1SG1594 ATOM 1594 O LEU 209 94..417 16..314 37..247 1.00 41.00 1SG1595
ATOM 1595 N GLY 210 92. .925 18. .000 37. .334 1. .00 39. ,34 1SG1596
ATOM 1596 CA GLY 210 92. .001 17, .265 38. .148 1. ,00 39. .34 1SG1597
ATOM 1597 C GLY 210 91. ,565 16, .011 37, .456 1. .00 39. .34 1SG1598
ATOM 1598 O GLY 210 91. ,551 14. .946 38. .072 1. .00 39. .34 1SG1599
ATOM 1599 N LYS 211 91. .181 16, .088 36. .166 1. ,00 39. ,75 1SG1600
ATOM 1600 CA LYS 211 90. .770 14, .883 35. .500 1. .00 39. .75 1SG1601
ATOM 1601 CB LYS 211 89. .262 14 .591 35 .590 1. .00 39. .75 1SG1602
ATOM 1602 CG LYS 211 88. .820 14, .013 36. .934 1. .00 39. .75 1SG1603
ATOM 1603 CD LYS 211 87. .301 13. .953 37, .104 1. ,00 39. ,75 1SG1604
ATOM 1604 CE LYS 211 86. .853 13, .079 38, .276 1. .00 39. .75 1SG1605
ATOM 1605 NZ LYS 211 87, .213 13 .721 39, .559 1. .00 39. .75 1SG1606
ATOM 1606 C LYS 211 91, .088 14, .998 34, .044 1. .00 39. .75 1SG1607
ATOM 1607 O LYS 211 90, .772 15 .995 33, .398 1. .00 39. .75 1SG1608
ATOM 1608 N PRO 212 91. .751 13, .995 33, .531 1. .00 39. .86 1SG1609
ATOM 1609 CA PRO 212 92. ,034 13 .994 32 .122 1. .00 39. .86 1SG1610
ATOM 1610 CD PRO 212 92. .840 13, .403 34, .294 1. .00 39. .86 1SG1611
ATOM 1611 CB PRO 212 93, .237 13 .075 31, .925 1. .00 39, .86 1SG1612
ATOM 1612 CG PRO 212 93. .963 13, .136 33, .279 1. .00 39. .86 1SG1613
ATOM 1613 C PRO 212 90. .842 13 .575 31, .321 1. .00 39. .86 1SG1614
ATOM 1614 O PRO 212 90. .155 12, .638 31, .725 1, .00 39. .86 1SG1615
ATOM 1615 N ILE 213 90. .586 14 .246 30, .181 1. .00 38. .79 1SG1616
ATOM 1616 CA ILE 213 89. .518 13 .864 29 .304 1, .00 38. .79 1SG1617
ATOM 1617 CB ILE 213 88, .279 14 .701 29, .433 1. .00 38. .79 1SG1618
ATOM 1618 CG2 ILE 213 87. .324 14, .280 28 .303 1. .00 38. .79 1SG1619
ATOM 1619 CGI ILE 213 87, .667 14 .572 30, .838 1. .00 38. .79 1SG1620
ATOM 1620 CD1 ILE 213 88, .493 15 .247 31 .932 1. .00 38. .79 1SG1621
ATOM 1621 C ILE 213 90, .023 14, .081 27, .914 1. ,00 38. .79 1SG1622
ATOM 1622 O ILE 213 90, .701 15 .071 27 .643 1. ,00 38. .79 1SG1623
ATOM 1623 N ILE 214 89. .690 13, .161 26, .992 1. .00 38, .35 1SG1624
ATOM 1624 CA ILE 214 90. .147 13 .273 25 .636 1. .00 38, .35 1SG1625
ATOM 1625 CB ILE 214 90 .359 11 .953 24 .954 1. .00 38 .35 1SG1626
ATOM 1626 CG2 ILE 214 88. .990 11 .267 24 .820 1. .00 38, .35 1SG1627
ATOM 1627 CGI ILE 214 91. .089 12, .151 23, .614 1. .00 38, .35 1SG1628
ATOM 1628 CD1 ILE 214 92. .525 12 .649 23, .765 1. .00 38, .35 1SG1629
ATOM 1629 C ILE 214 89 .119 14 .024 24 .850 1. .00 38 .35 1SG1630
ATOM 1630 O ILE 214 87. .919 13 .860 25. .062 1, .00 38, .35 1SG1631
ATOM 1631 N LEU 215 89. .586 14, .897 23, .936 1. .00 35, .39 1SG1632
ATOM 1632 CA LEU 215 88. .714 15 .698 23, .124 1. .00 35, .39 1SG1633
ATOM 1633 CB LEU 215 89 .454 16 .786 22 .327 1. .00 35, .39 1SG1634
ATOM 1634 CG LEU 215 90 .140 17 .842 23 .217 1. .00 35 .39 1SG1635
ATOM 1635 CD2 LEU 215 89. .148 18, .454 24, .219 1. .00 35, .39 1SG1636
ATOM 1636 CD1 LEU 215 90, .861 18, .903 22, .369 1. .00 35. .39 1SG1637
ATOM 1637 C LEU 215 88 .021 14 .810 22, .138 1. .00 35. .39 1SG1638
ATOM 1638 o LEU 215 88 .564 13 .826 21 .640 1. .00 35, .39 1SG1639
ATOM 1639 N PRO 216 86. .798 15 .168 21, .872 1. .00 32. .44 1SG1640
ATOM 1640 CA PRO 216 85. .954 14, .434 20, .970 1. .00 32. .44 1SG1641
ATOM 1641 CD PRO 216 86, .029 15 .954 22, .819 1. .00 32. .44 1SG1642
ATOM 1642 CB PRO 216 84 .523 14 .908 21 .246 1. .00 32, .44 1SG1643
ATOM 1643 CG PRO 216 84 .683 16 .171 22 .112 1, .00 32, .44 1SG1644
ATOM 1644 C PRO 216 86. .357 14, .543 19. .531 1. .00 32. .44 1SG1645
ATOM 1645 O PRO 216 85. .803 13, .805 18. .719 1. .00 32. .44 1SG1646
ATOM 1646 N THR 217 87. .284 15 .448 19. .167 1. .00 30. .94 1SG1647
ATOM 1647 CA THR 217 87 .581 15 .575 17 .767 1. .00 30, .94 1SG1648
ATOM 1648 CB THR 217 87. .183 16, .906 17. .200 1. 00 30. .94 1SG1649
ATOM 1649 OGl THR 217 87. .275 16, .889 15. .782 1. ,00 30. .94 1SG1650
ATOM 1650 CG2 THR 217 88. .111 17. .987 17. .781 1. .00 30. .94 1SG1651 ATOM 1651 C THR 217 89..053 15..420 17..542 1..00 30..94 1SG1652
ATOM 1652 O THR 217 89. .827 15. .248 18, .482 1. .00 30. .94 1SG1653
ATOM 1653 N ASP 218 89. ,458 15. .439 16. .252 1. .00 29. .31 1SG1654
ATOM 1654 CA ASP 218 90. ,831 15. .312 15. .854 1. .00 29. ,31 1SG1655
ATOM 1655 CB ASP 218 91. .052 14. .243 14, .769 1, .00 29. .31 1SG1656
ATOM 1656 CG ASP 218 90. .756 12. .878 15. .373 1. .00 29. .31 1SG1657
ATOM 1657 OD1 ASP 218 91. .118 12. .663 16. .561 1. .00 29, .31 1SG1658
ATOM 1658 OD2 ASP 218 90. .169 12. .029 14, .651 1. .00 29, .31 1SG1659
ATOM 1659 C ASP 218 91. .254 16. .626 15, .267 1. .00 29. .31 1SG1660
ATOM 1660 O ASP 218 90. .433 17, .368 14, .729 1. .00 29, .31 1SG1661
ATOM 1661 N ALA 219 92. .559 16. .953 15, .370 1. .00 31. .34 1SG1662
ATOM 1662 CA ALA 219 93. .069 18. .195 14. .855 1. .00 31. .34 1SG1663
ATOM 1663 CB ALA 219 94. .498 18, .514 15. .326 1. .00 31, .34 1SG1664
ATOM 1664 C ALA 219 93. .085 18, .132 13, .358 1. .00 31. .34 1SG1665
ATOM 1665 O ALA 219 93, .197 17, .058 12 .770 1 .00 31. .34 1SG1666
ATOM 1666 N THR 220 92. ,957 19. .303 12. .699 1. .00 34. .38 1SG1667
ATOM 1667 CA THR 220 92. .950 19, .335 11. .263 1, .00 34, .38 1SG1668
ATOM 1668 CB THR 220 92. .220 20, .514 10 .690 1 .00 34, .38 1SG1669
ATOM 1669 OGl THR 220 92, .860 21, .722 11. .075 1. .00 34 , .38 1SG1670
ATOM 1670 CG2 THR 220 90, .769 20. .495 11, .201 1. .00 34. .38 1SG1671
ATOM 1671 C THR 220 94. .362 19. .410 10, .781 1. .00 34. .38 1SG1672
ATOM 1672 O THR 220 95. .270 19, .784 11, .521 1. .00 34, .38 1SG1673
ATOM 1673 N PRO 221 94, .580 19 .014 9 .555 1 .00 3 .39 1SG1674
ATOM 1674 CA PRO 221 95. .896 19, .135 9. .000 1. .00 39. .39 1SG1675
ATOM 1675 CD PRO 221 93. .837 17, .926 8, .948 1. .00 39, .39 1SG1676
ATOM 1676 CB PRO 221 95. .933 18, .230 7. .765 1. .00 39, .39 1SG1677
ATOM 1677 CG PRO 221 94. .466 17, .802 7 .551 1 .00 39. .39 1SG1678
ATOM 1678 C PRO 221 96. .133 20, .583 8, .737 1. .00 39 .39 1SG1679
ATOM 1679 O PRO 221 95. .253 21, .228 8. .170 1, .00 39. .39 1SG1680
ATOM 1680 N PHE 222 97. .311 21, .115 9 .115 1 .00 48. .46 1SG1681
ATOM 1681 CA PHE 222 97, .512 2 .519 8 .918 1. .00 48 .46 1SG1682
ATOM 1682 CB PHE 222 98, .283 23, .208 10, .051 1, .00 48, .46 1SG1683
ATOM 1683 CG PHE 222 97, .622 22 .866 11 .329 1 .00 48, .46 1SG1684
ATOM 1684 CD1 PHE 222 96, .479 23, .509 11, .735 1, .00 48. .46 1SG1685
ATOM 1685 CD2 PHE 222 98 .180 21 .892 12 .119 1 .00 48. .46 1SG1686
ATOM 1686 CE1 PHE 222 95, .894 23 .168 12 .927 1 .00 48 .46 1SG1687
ATOM 1687 CE2 PHE 222 97, .600 21, .548 13, .310 1, .00 48. .46 1SG1688
ATOM 1688 CZ PHE 222 96 .458 2 .187 13 .708 1 .00 48. .46 1SG1689
ATOM 1689 C PHE 222 98, .435 22, .681 7, .764 1, .00 48, .46 1SG1690
ATOM 1690 O PHE 222 99, .634 22 .438 7 .899 1 .00 48, .46 1SG1691
ATOM 1691 N VAL 223 97, .907 23 .125 6, .609 1, .00 55, .33 1SG1692
ATOM 1692 CA VAL 223 98, .784 23, .376 5, .507 1, .00 55. .33 1SG1693
ATOM 1693 CB VAL 223 98 .280 22 .860 4 .192 1 .00 55. .33 1SG1694
ATOM 1694 CGI VAL 223 99 .233 23, .342 3, .085 1, .00 55. .33 1SG1695
ATOM 1695 CG2 VAL 223 98, .153 21, .331 4, .285 1, .00 55. .33 1SG1696
ATOM 1696 C VAL 223 98 .871 24 .860 5, .397 1, .00 55. .33 1SG1697
ATOM 1697 O VAL 223 97, .893 25, .533 5, .080 1, .00 55. .33 1SG1698
ATOM 1698 N LEU 224 100 .070 25 .403 5 .658 1 .00 63, .74 1SG1699
ATOM 1699 CA LEU 224 100, .284 26. .818 5. .638 1. .00 63. .74 1SG1700
ATOM 1700 CB LEU 224 101, .406 27. .265 6. .598 1. .00 63. .74 1SG1701
ATOM 1701 CG LEU 224 101 .143 26 .958 8. .083 1. .00 63, .74 1SG1702
ATOM 1702 CD2 LEU 224 102 .134 27. .708 8. .988 1. .00 63. .74 1SG1703
ATOM 1703 CD1 LEU 224 101, .124 25, .445 8 .345 1. .00 63. .74 1SG1704
ATOM 1704 C LEU 224 100, .712 27, .184 4. .259 1. .00 63. ,74 1SG1705
ATOM 1705 O LEU 224 101, .117 26, .318 3, .488 1. .00 63. .74 1SG1706
ATOM 1706 N PRO 225 100 .718 28 .457 3. .959 1, .00 67. .10 1SG1707
ATOM 1707 CA PRO 225 100. .923 28 .951 2. .632 1. .00 67. .10 1SG1708 oo θ H CN r f in vo .- oo σ. CN cι -f in mmm ro M r ^^ ^^ ^^ ^* ^^ ^* ^* ^ϊ^ ^^ in in in m in in in in in in vo vo io io r- r- r- r- O CD CD CD CD CD CD CD CD CD CD P CD CD P O CD H H H H H H H H
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ATOM 1765 N SER 233 108..139 36..037 7,.773 1..00 35,.88 1SG1766
ATOM 1766 CA SER 233 108, .375 36. .144 9, .185 1. .00 35, .88 1SG1767
ATOM 1767 CB SER 233 107, .103 35. .951 10, .028 1. .00 35, .88 1SG1768
ATOM 1768 OG SER 233 106, .608 34. .630 9, .862 1. .00 35, .88 1SG1769
ATOM 1769 C SER 233 109, .324 35. .060 9, .579 1. .00 35, .88 1SG1770
ATOM 1770 O SER 233 109, .556 34. .120 8, .823 1. .00 35, .88 1SG1771
ATOM 1771 N MET 234 109 .947 35. .209 10 .766 1. .00 35 .91 1SG1772
ATOM 1772 CA MET 234 110 .876 34, .232 11 .254 1, .00 35 .91 1SG1773
ATOM 1773 CB MET 234 111 .525 34, .660 12 .582 1, .00 35 .91 1SG1774
ATOM 1774 CG MET 234 112 .428 35, .895 12 .492 1. .00 35 .91 1SG1775
ATOM 1775 SD MET 234 114 .061 35, .597 11 .750 1. .00 35 .91 1SG1776
ATOM 1776 CE MET 234 114 .764 37. .210 12, .199 1. .00 35 .91 1SG1777
ATOM 1777 C MET 234 110. .159 32. .944 11. .536 1. .00 35 .91 1SG1778
ATOM 1778 O MET 234 110, .581 31. .878 11. .088 1. .00 35 .91 1SG1779
ATOM 1779 N ALA 235 109, .026 33. .004 12. .266 1. .00 35, .82 1SG1780
ATOM 1780 CA ALA 235 108, .382 31. .777 12. .636 1. .00 35, .82 1SG1781
ATOM 1781 CB ALA 235 108, .571 31. .408 14. .117 1. .00 35, .82 1SG1782
ATOM 1782 C ALA 235 106 .915 31. .896 12 .399 1. .00 35 .82 1SG1783
ATOM 1783 O ALA 235 106 .362 32. .994 12 .376 1. .00 35 .82 1SG1784
ATOM 1784 N THR 236 106 .255 30, .738 12 .188 1. .00 37 .38 1SG1785
ATOM 1785 CA THR 236 104 .842 30. .737 11 .983 1. .00 37 .38 1SG1786
ATOM 1786 CB THR 236 104 .437 30. .413 10 .578 1. .00 37 .38 1SG1787
ATOM 1787 OGl THR 236 104 .847 29. .096 10. .243 1. .00 37 .38 1SG1788
ATOM 1788 CG2 THR 236 105 .095 31. .428 9, .631 1, .00 37 .38 1SG1789
ATOM 1789 C THR 236 104, .260 29. .669 12, .847 1, .00 37 .38 1SG1790
ATOM 1790 O THR 236 104, .842 28. .599 13, .024 1. .00 37 .38 1SG1791
ATOM 1791 N VAL 237 103. .076 29. .941 13, .422 1. .00 36 .56 1SG1792
ATOM 1792 CA VAL 237 102, .458 28. .944 14, .235 1. .00 36 .56 1SG1793
ATOM 1793 CB VAL 237 102, .367 29. .313 15, .688 1. .00 36, .56 1SG1794
ATOM 1794 CGI VAL 237 101 .601 28. .201 16 .426 1, .00 36 .56 1SG1795
ATOM 1795 CG2 VAL 237 103 .802 29. .530 16 .208 1. .00 36 .56 1SG1796
ATOM 1796 C VAL 237 101 .086 28. .727 13 .691 1. .00 36 .56 1SG1797
ATOM 1797 O VAL 237 100 .443 29. .643 13 .182 1. .00 36 .56 1SG1798
ATOM 1798 N GLY 238 100, .616 27. .470 13, .759 1. .00 35 .29 1SG1799
ATOM 1799 CA GLY 238 99 .293 27. .187 13, .306 1. .00 35 .29 1SG1800
ATOM 1800 C GLY 238 98, .550 26. .748 14. .520 1. .00 35 .29 1SG1801
ATOM 1801 O GLY 238 98, .807 25. .681 15, .075 1. .00 35, .29 1SG1802
ATOM 1802 N LEU 239 97, .593 27. .580 14, .962 1. .00 34, .94 1SG1803
ATOM 1803 CA LEU 239 96, .838 27. .271 16. .137 1. .00 34, .94 1SG1804
ATOM 1804 CB LEU 239 96 , .566 28. .533 16. .975 1. .00 34, .94 1SG1805
ATOM 1805 CG LEU 239 97 .856 29. .245 17. .437 1. .00 34 .94 1SG1806
ATOM 1806 CD2 LEU 239 98, .792 28. .294 18, .201 1. .00 34, .94 1SG1807
ATOM 1807 CD1 LEU 239 97, .530 30. .496 18, .264 1. .00 34, .94 1SG1808
ATOM 1808 C LEU 239 95, .529 26. .721 15. .660 1. .00 34, .94 1SG1809
ATOM 1809 O LEU 239 94, .673 27. .456 15. .173 1. .00 34, .94 1SG1810
ATOM 1810 N SER 240 95, .342 25. .397 15, .806 1. .00 33, .16 1SG1811
ATOM 1811 CA SER 240 94, .173 24. .719 15, .318 1. .00 33. .16 1SG1812
ATOM 1812 CB SER 240 94. .278 23. .190 15, .391 1. .00 33. .16 1SG1813
ATOM 1813 OG SER 240 94. .448 22. .776 16, .739 1. ,00 33. .16 1SG1814
ATOM 1814 C SER 240 92. .983 25. ,052 16. .146 1. ,00 33. .16 1SG1815
ATOM 1815 O SER 240 93. .090 25. .532 17. .272 1. ,00 33. .16 1SG1816
ATOM 1816 N GLN 241 91, .798 24. .779 15, .568 1. .00 33. .78 1SG1817
ATOM 1817 CA GLN 241 90, .544 24. .990 16, .222 1. .00 33. .78 1SG1818
ATOM 1818 CB GLN 241 89, .328 24. .644 15, .346 1. ,00 33. .78 1SG1819
ATOM 1819 CG GLN 241 89. .225 23. .151 15. .023 1. ,00 33. .78 1SG1820
ATOM 1820 CD GLN 241 87. .924 22. .909 14. .269 1. ,00 33. .78 1SG1821
ATOM 1821 OEl GLN 241 87. .681 23. ,493 13. .214 1. 00 33. ,78 1SG1822 ATOM 1822 NE2 GLN 241 87,.059 22..022 14..829 1..00 33..78 1SG1823
ATOM 1823 C GLN 241 90, .503 24. .057 17. .385 1. .00 33. .78 1SG1824
ATOM 1824 O GLN 241 89. .958 24. .385 18. .437 1. .00 33. .78 1SG1825
ATOM 1825 N GLN 242 91. .088 22. .855 17. .218 1. .00 34. .38 1SG1826
ATOM 1826 CA GLN 242 91, .058 21. .882 18. .269 1. .00 34. .38 1SG1827
ATOM 1827 CB GLN 242 91 .785 20. .570 17. .927 1. .00 34. .38 1SG1828
ATOM 1828 CG GLN 242 91, .735 19, .557 19. .075 1. ,00 34. .38 1SG1829
ATOM 1829 CD GLN 242 92 .356 18, .250 18, .604 1. .00 34. .38 1SG1830
ATOM 1830 OEl GLN 242 91, .759 17, .519 17. .816 1. .00 34. .38 1SG1831
ATOM 1831 NE2 GLN 242 93, .583 17. .941 19. .104 1. .00 34. .38 1SG1832
ATOM 1832 C GLN 242 91, .735 22, .467 19. .461 1. ,00 34. .38 1SG1833
ATOM 1833 0 GLN 242 91 .281 22, .297 20, .591 1. .00 34. .38 1SG1834
ATOM 1834 N LEU 243 92, .840 23. .200 19. .238 1. .00 34. .69 1SG1835
ATOM 1835 CA LEU 243 93, .579 23. .742 20. .338 1. .00 34. .69 1SG1836
ATOM 1836 CB LEU 243 94, .801 24, .547 19. .843 1. .00 34, .69 1SG1837
ATOM 1837 CG LEU 243 95 .806 25, .045 20. .910 1. .00 34, .69 1SG1838
ATOM 1838 CD2 LEU 243 95, .158 25. .895 22. .015 1. .00 34 .69 1SG1839
ATOM 1839 CD1 LEU 243 96, .961 25. .799 20. .233 1. .00 34. .69 1SG1840
ATOM 1840 C LEU 243 92 .663 24. .645 21. .110 1. .00 34, .69 1SG1841
ATOM 1841 o LEU 243 92 .569 24. .543 22. .333 1. .00 34 .69 1SG1842
ATOM 1842 N PHE 244 91 .946 25, .542 20, .411 1. .00 34 .48 1SG1843
ATOM 1843 CA PHE 244 91, .081 26. .488 21. .060 1. ,00 34. .48 1SG1844
ATOM 1844 CB PHE 244 90, .482 27, .516 20. .085 1. .00 34, .48 1SG1845
ATOM 1845 CG PHE 244 91 .586 28, .402 19. .616 1, .00 34 .48 1SG1846
ATOM 1846 CD1 PHE 244 92, .378 28, .046 18. .549 1. .00 34, .48 1SG1847
ATOM 1847 CD2 PHE 244 91, .832 29, .597 20. .249 1. .00 34, .48 1SG1848
ATOM 1848 CE1 PHE 244 93 .394 28, .871 18, .124 1. .00 34, .48 1SG1849
ATOM 1849 CE2 PHE 244 92 .846 30 .425 19, .827 1, .00 34, .48 1SG1850
ATOM 1850 CZ PHE 244 93 .631 30, .064 18, .761 1, .00 34, .48 1SG1851
ATOM 1851 C PHE 244 89. .937 25, .789 21. .730 1. .00 34. .48 1SG1852
ATOM 1852 O PHE 244 89 .558 26, .138 22. .847 1. .00 34. .48 1SG1853
ATOM 1853 N ASP 245 89 .344 24 .791 21. .053 1. .00 31 .25 1SG1854
ATOM 1854 CA ASP 245 88 .186 24 , .109 21, .558 1, .00 31, .25 1SG1855
ATOM 1855 CB ASP 245 87, .593 23 , .122 20. .540 1. .00 31, .25 1SG1856
ATOM 1856 CG ASP 245 86 .935 23, .948 19. .442 1. .00 31, .25 1SG1857
ATOM 1857 OD1 ASP 245 86 .124 24 .849 19, .785 1. .00 31 .25 1SG1858
ATOM 1858 OD2 ASP 245 87 .246 23, .701 18, .247 1. .00 31, .25 1SG1859
ATOM 1859 C ASP 245 88, .509 23, .356 22, .812 1. .00 31 .25 1SG1860
ATOM 1860 O ASP 245 87, .673 23, .260 23, .708 1, .00 31, .25 1SG1861
ATOM 1861 N SER 246 89 .726 22, .792 22. .916 1, .00 28, .05 1SG1862
ATOM 1862 CA SER 246 90 .069 22, .013 24, .073 1. .00 28, .05 1SG1863
ATOM 1863 CB SER 246 91. .496 21, .441 24, .000 1. .00 28, .05 1SG1864
ATOM 1864 OG SER 246 92. .447 22, .495 23, .996 1. .00 28, .05 1SG1865
ATOM 1865 C SER 246 89, .999 22. .886 25, .285 1. ,00 28. .05 1SG1866
ATOM 1866 o SER 246 89, .699 22. .419 26, .383 1. .00 28. .05 1SG1867
ATOM 1867 N ALA 247 90, .294 24. .186 25, .121 1. .00 27, .31 1SG1868
ATOM 1868 CA ALA 247 90. .267 25, .073 26, .245 1. .00 27. .31 1SG1869
ATOM 1869 CB ALA 247 90. .705 26. .501 25. .884 1. .00 27. ,31 1SG1870
ATOM 1870 C ALA 247 88, .873 25. .152 26. .778 1. .00 27. .31 1SG1871
ATOM 1871 O ALA 247 88 .653 25. .074 27. .985 1. .00 27, .31 1SG1872
ATOM 1872 N LEU 248 87, .884 25. .287 25. .876 1. ,00 28. .36 1SG1873
ATOM 1873 CA LEU 248 86. .521 25. .455 26. .287 1. ,00 28. .36 1SG1874
ATOM 1874 CB LEU 248 85, .593 25. .763 25. .095 1. .00 28. .36 1SG1875
ATOM 1875 CG LEU 248 85, .940 27. .117 24. .444 1. .00 28, .36 1SG1876
ATOM 1876 CD2 LEU 248 85, .961 28. .238 25, .496 1. .00 28, .36 1SG1877
ATOM 1877 CD1 LEU 248 85. .025 27. ,447 23. .257 1. .00 28. .36 1SG1878 TOM 1878 C LEU 248 86. .049 24. .228 27. .001 1. .00 28. .36 1SG1879 ATOM 1879 O LEU 248 85..335 24..325 27.,998 1.00 28.36 1SG1880
ATOM 1880 N LEU 249 86. ,435 23. .036 26 , .511 1. .00 33. .84 1SG1881
ATOM 1881 CA LEU 249 85. ,986 21. ,816 27. .113 1. .00 33. 84 1SG1882
ATOM 1882 CB LEU 249 86, ,457 20. .574 26. .339 1. .00 33. ,84 1SG1883
ATOM 1883 CG LEU 249 85. .991 19. .239 26. .951 1. ,00 33. 84 1SG1884
ATOM 1884 CD2 LEU 249 86. .709 18. 051 26. .289 1. .00 33. ,84 1SG1885
ATOM 1885 CD1 LEU 249 84. .460 19, .104 26. .910 1. .00 33. 84 1SG1886
ATOM 1886 C LEU 249 86. .513 21. .716 28. .513 1. .00 33. ,84 1SG1887
ATOM 1887 O LEU 249 85. ,784 21. .352 29. .434 1. ,00 33. ,84 1SG1888
ATOM 1888 N LEU 250 87. ,801 22. .034 28. .712 1. .00 40. .29 1SG1889
ATOM 1889 CA LEU 250 88. ,386 21, ,897 30, .016 1. .00 40. ,29 1SG1890
ATOM 1890 CB LEU 250 89, ,892 22, .082 30. .018 1. .00 40. .29 1SG1891
ATOM 1891 CG LEU 250 90. .565 20, .969 29. .222 1. .00 40. .29 1SG1892
ATOM 1892 CD2 LEU 250 89. .969 19. .587 29. .548 1. .00 40. .29 1SG1893
ATOM 1893 CD1 LEU 250 92. .061 21. .041 29. .449 1. .00 40. .29 1SG1894
ATOM 1894 C LEU 250 87, .806 22. .866 30. .990 1. .00 40. .29 1SG1895
ATOM 1895 O LEU 250 87. .615 22. .532 32 .157 1, .00 40. .29 1SG1896
ATOM 1896 N LEU 251 87. .538 24. .107 30. .552 1. .00 42. .57 1SG1897
ATOM 1897 CA LEU 251 87. ,006 25. ,100 31. .443 1. .00 42, .57 1SG1898
ATOM 1898 CB LEU 251 86, .847 26. .482 30. .781 1. .00 42. .57 1SG1899
ATOM 1899 CG LEU 251 88, .186 27. .136 30, .390 1. .00 42. .57 1SG1900
ATOM 1900 CD2 LEU 251 89, .144 27. .196 31, .592 1. .00 42. .57 1SG1901
ATOM 1901 CD1 LEU 251 87, .966 28. .514 29 .742 1. .00 42. .57 1SG1902
ATOM 1902 C LEU 251 85, .641 24. .676 31, .887 1. .00 42. .57 1SG1903
ATOM 1903 O LEU 251 85. .278 24. .854 33, .047 1, .00 42. .57 1SG1904
ATOM 1904 N GLN 252 84. .831 24. .131 30. .957 1. .00 43. .44 1SG1905
ATOM 1905 CA GLN 252 83. .481 23. .751 31, .271 1 .00 43 .44 1SG1906
ATOM 1906 CB GLN 252 82 .699 23, .239 30 .046 1. .00 43. .44 1SG1907
ATOM 1907 CG GLN 252 81 .473 22, .389 30, .419 1 .00 43 .44 1SG1908
ATOM 1908 CD GLN 252 80, .440 23, .269 31 .093 1. .00 43. .44 1SG1909
ATOM 1909 OEl GLN 252 81 .095 23, .227 30, .053 1 .00 43 .44 1SG1910
ATOM 1910 NE2 GLN 252 80, .292 22 .492 32 .200 1. .00 43 .44 1SG1911
ATOM 1911 C GLN 252 83 .407 22, .634 32, .262 1 .00 43 .44 1SG1912
ATOM 1912 O GLN 252 82, .715 22, .742 33 .272 1. .00 43, .44 1SG1913
ATOM 1913 N LYS 253 84 .147 21, .540 32, .012 1. .00 39 .59 1SG1914
ATOM 1914 CA LYS 253 84, .031 20. .370 32, .835 1, .00 39. .59 1SG1915
ATOM 1915 CB LYS 253 84, .817 19. .158 32, .306 1. .00 39 .59 1SG1916
ATOM 1916 CG LYS 253 84, .102 18, .524 31, .109 1, .00 39, .59 1SG1917
ATOM 1917 CD LYS 253 84 .869 17. .413 30, .392 1, .00 39 .59 1SG1918
ATOM 1918 CE LYS 253 84, .041 16. .763 29, .280 1, .00 39, .59 1SG1919
ATOM 1919 NZ LYS 253 84, .778 15, .630 28, .682 1. .00 39 .59 1SG1920
ATOM 1920 C LYS 253 84 .443 20, .688 34 .233 1 .00 39 .59 1SG1921
ATOM 1921 O LYS 253 83 .991 20 .047 35 .181 1, .00 39 .59 1SG1922
ATOM 1922 N ALA 254 85 .331 21, .679 34 .391 1, .00 36 .60 1SG1923
ATOM 1923 CA ALA 254 85 .783 22 .091 35 .687 1. .00 36, .60 1SG1924
ATOM 1924 CB ALA 254 86 .821 23, .224 35 .623 1, .00 36 .60 1SG1925
ATOM 1925 C ALA 254 84 .599 2 .589 36, .461 1, . 00 36, .60 1SG1926
ATOM 1926 O ALA 254 84 .531 22. .404 37. .674 1, .00 36 .60 1SG1927
ATOM 1927 N GLY 255 83 .632 23 .244 35, .785 1, . 00 36, .30 1SG1928
ATOM 1928 CA GLY 255 82 .472 23. .748 36, .469 1, .00 36 .30 1SG1929
ATOM 1929 C GLY 255 82 .702 25 .190 36, .790 1. .00 36, .30 1SG1930
ATOM 1930 O GLY 255 81 .949 25, .801 37, .547 1. .00 36 .30 1SG1931
ATOM 1931 N ALA 256 83, .796 25, .748 36, .243 1, .00 38, .39 . 1SG1932
ATOM 1932 CA ALA 256 84 .199 27, .113 36, .425 1, .00 38 .39 1SG1933
ATOM 1933 CB ALA 256 85, .615 27. .383 35, .888 1, .00 38, .39 1SG1934
ATOM 1934 C ALA 256 83, .279 28. .082 35, .748 1. .00 38, .39 1SG1935
ATOM 1935 O ALA 256 83 .033 29. .164 36 .276 1. .00 38 .39 1SG1936 ATOM 1936 N LEU 257 82..767 27..738 34..551 1.00 42..12 1SG1937
ATOM 1937 CA LEU 257 82. .033 28. .708 33, .790 1. .00 42. .12 1SG1938
ATOM 1938 CB LEU 257 81 .922 28, .265 32, .318 1. .00 42. .12 1SG1939
ATOM 1939 CG LEU 257 81. .457 29. ,331 31. .311 1. ,00 42. .12 1SG1940
ATOM 1940 CD2 LEU 257 80, .142 30. .003 31. .723 1. ,00 42. .12 1SG1941
ATOM 1941 CD1 LEU 257 81, .401 28. .740 29. .895 1. .00 42. .12 1SG1942
ATOM 1942 C LEU 257 80. .662 28. .856 34. .382 1. .00 42. .12 1SG1943
ATOM 1943 O LEU 257 79. .675 28. .339 33 .856 1, .00 42, .12 1SG1944
ATOM 1944 N ASN 258 80. .574 29. .613 35, .494 1. ,00 43. .87 1SG1945
ATOM 1945 CA ASN 258 79 .323 29, .873 36 .139 1. .00 43. .87 1SG1946
ATOM 1946 CB ASN 258 78. .982 28. .862 37, .246 1. .00 43. .87 1SG1947
ATOM 1947 CG ASN 258 80 .037 28. .980 38 .337 1. .00 43, .87 1SG1948
ATOM 1948 OD1 ASN 258 81 .217 29. .185 38, .060 1. .00 43, .87 1SG1949
ATOM 1949 ND2 ASN 258 79. .600 28. .849 39, .619 1. .00 43. .87 1SG1950
ATOM 1950 C ASN 258 79 .443 31. .216 36, .785 1. .00 43. .87 1SG1951
ATOM 1951 O ASN 258 80 .524 31. .599 37 .230 1. .00 4 .87 1SG1952
ATOM 1952 N LEU 259 78, .337 31. ,985 36. .833 1. ,00 46. .29 1SG1953
ATOM 1953 CA LEU 259 78, .413 33. .264 37. .475 1. .00 46, .29 1SG1954
ATOM 1954 CB LEU 259 78 .812 34. .416 36 .527 1. .00 46 .29 1SG1955
ATOM 1955 CG LEU 259 77, .927 34. .595 35 .275 1. .00 46, .29 1SG1956
ATOM 1956 CD2 LEU 259 76, .510 35. .073 35. .627 1. .00 46 .29 1SG1957
ATOM 1957 CD1 LEU 259 77, .957 33. .343 34. .382 1. .00 46, .29 1SG1958
ATOM 1958 C LEU 259 77 .090 33, .573 38 .099 1, .00 46 .29 1SG1959
ATOM 1959 O LEU 259 76 .040 33, .203 37 .576 1, .00 46 .29 1SG1960
ATOM 1960 N ASP 260 77, .115 34. .251 39 .264 1, .00 46 .35 1SG1961
ATOM 1961 CA ASP 260 75 .896 34. .610 39 .928 1, .00 46 .35 1SG1962
ATOM 1962 CB ASP 260 75, .839 34. .167 41, .403 1. .00 46, .35 1SG1963
ATOM 1963 CG ASP 260 76 .952 34. .869 42 .169 1. .00 46 .35 1SG1964
ATOM 1964 OD1 ASP 260 78 .037 35 .093 41 .570 1 .00 46 .35 1SG1965
ATOM 1965 OD2 ASP 260 76, .730 35. .194 43, .367 1. .00 46, .35 1SG1966
ATOM 1966 C ASP 260 75 .783 36. .099 39 .892 1. .00 46 .35 1SG1967
ATOM 1967 O ASP 260 76 .719 36 .815 40 .247 1. .00 46 .35 1SG1968
ATOM 1968 N ILE 261 74 .624 36, .612 39 .438 1. .00 47 .61 1SG1969
ATOM 1969 CA ILE 261 74 .461 38, .035 39 .401 1. .00 47, .61 1SG1970
ATOM 1970 CB ILE 261 74 .139 38, .596 38 .042 1, .00 47 .61 1SG1971
ATOM 1971 CG2 ILE 261 75 .363 38, .364 37 .141 1, .00 47, .61 1SG1972
ATOM 1972 CGI ILE 261 72 .842 37, .995 37 .481 1, .00 4 .61 1SG1973
ATOM 1973 CD1 ILE 261 72 .976 36. .511 37, .146 1. .00 47 .61 1SG1974
ATOM 1974 C ILE 261 73 .380 38. .410 40 .353 1. .00 47 .61 1SG1975
ATOM 1975 O ILE 261 72 .316 37, .793 40, .390 1. .00 47, .61 1SG1976
ATOM 1976 N THR 262 73 .653 39, .430 41 .193 1. .00 48 .13 1SG1977
ATOM 1977 CA THR 262 72 .648 39, .796 42, .139 1. .00 48 .13 1SG1978
ATOM 1978 CB THR 262 72, .954 39. .347 43, .537 1. .00 48, .13 1SG1979
ATOM 1979 OGl THR 262 74 .138 39, .976 44 .004 1. .00 48 .13 1SG1980
ATOM 1980 CG2 THR 262 73 .129 37, .819 43 .536 1. .00 48 .13 1SG1981
ATOM 1981 C THR 262 72, .492 41. .280 42, .196 1. .00 48, .13 1SG1982
ATOM 1982 O THR 262 73 .467 42. .028 42, .169 1. .00 48. .13 1SG1983
ATOM 1983 N GLY 263 71 .216 41. .710 42, .223 1. .00 45. .92 1SG1984
ATOM 1984 CA GLY 263 70, .714 43. .029 42, .501 1. .00 45, .92 1SG1985
ATOM 1985 C GLY 263 71, .720 44, ,130 42 .359 1, .00 45, .92 1SG1986
ATOM 1986 O GLY 263 71 .684 44. .920 41, .419 1. .00 45, .92 1SG1987
ATOM 1987 N GLN 264 72 .627 44, .209 43, .352 1. .00 44, .34 1SG1988
ATOM 1988 CA GLN 264 73 .553 45. .285 43, .573 1. .00 44, .34 1SG1989
ATOM 1989 CB GLN 264 74 .484 45, ,026 44, .769 1. .00 44, .34 1SG1990
ATOM 1990 CG GLN 264 75, .479 46. .158 45, .030 1. .00 44, .34 1SG1991
ATOM 1991 CD GLN 264 76, .328 45. .770 46. .231 1. .00 44, .34 1SG1992
ATOM 1992 OEl GLN 264 76, .165 44. .692 46. .802 1. .00 44, .34 1SG1993 ATOM 1993 NE2 GLN 264 77..266 46,.671 46..628 1..00 44..34 1SG1994
ATOM 1994 C GLN 264 74. .424 45 .551 42. .388 1. .00 44, .34 1SG1995
ATOM 1995 O GLN 264 7 .763 46 .703 42. .123 1, .00 44 .34 1SG1996
ATOM 1996 N LEU 265 74. .817 44. .514 41. .639 1. .00 42, .66 1SG1997
ATOM 1997 CA LEU 265 75. .721 44, .753 40. .552 1. .00 42. .66 1SG1998
ATOM 1998 CB LEU 265 16. .078 43, .475 39, .768 1, .00 42, .66 1SG1999
ATOM 1999 CG LEU 265 76 .929 42 .474 40, .573 1. .00 42 .66 1SG2000
ATOM 2000 CD2 LEU 265 76. .189 41 .978 41, .824 1, .00 42, .66 1SG2001
ATOM 2001 CD1 LEU 265 78. .316 43, .053 40. .892 1. .00 42, .66 1SG2002
ATOM 2002 C LEU 265 75. .109 45, .721 39, .582 1. .00 42, .66 1SG2003
ATOM 2003 O LEU 265 75 .814 46 .544 39 .002 1. .00 42 .66 1SG2004
ATOM 2004 N ARG 266 73. .783 45, .648 39, .368 1. .00 43, .73 1SG2005
ATOM 2005 CA ARG 266 73. .144 46, .472 38. .377 1. .00 43, .73 1SG2006
ATOM 2006 CB ARG 266 71. .765 45, .927 37, .973 1. .00 43 .73 1SG2007
ATOM 2007 CG ARG 266 71 .835 44 .446 37, .602 1, .00 43 .73 1SG2008
ATOM 2008 CD ARG 266 70. .553 43, .872 37 , .001 1, .00 43 .73 1SG2009
ATOM 2009 NE ARG 266 70, .705 42 , .390 37. .020 1, .00 43 .73 1SG2010
ATOM 2010 CZ ARG 266 71. .588 41, .785 36, .174 1, .00 43 .73 1SG2011
ATOM 2011 NH1 ARG 266 72 .368 42 .544 35, .349 1, .00 43 .73 1SG2012
ATOM 2012 NH2 ARG 266 71. .700 40, .425 36, .161 1, .00 43 .73 1SG2013
ATOM 2013 C ARG 266 72. .958 47, .882 38, .854 1, .00 43 .73 1SG2014
ATOM 2014 O ARG 266 72. .630 48, .131 40, .014 1, .00 43 .73 1SG2015
ATOM 2015 N SER 267 73 .205 48 .848 37, .939 1, .00 47 .45 1SG2016
ATOM 2016 CA SER 267 73 .050 50 .251 38, .208 1, .00 47 .45 1SG2017
ATOM 2017 CB SER 267 73. .590 51, .134 37, .070 1, .00 47 .45 1SG2018
ATOM 2018 OG SER 267 74. .990 50, .943 36. .926 1. .00 47 .45 1SG2019
ATOM 2019 C SER 267 71 .602 50, .605 38. .392 1. .00 4 .45 1SG2020
ATOM 2020 O SER 267 71 .172 50 .884 39. .510 1 .00 47 .45 1SG2021
ATOM 2021 N ASP 268 70 .801 50, .603 37. .297 1. .00 50 .40 1SG2022
ATOM 2022 CA ASP 268 69. .433 51. .016 37. .466 1. .00 50, .40 1SG2023
ATOM 2023 CB ASP 268 69 .307 52. .524 37, .760 1, .00 50 .40 1SG2024
ATOM 2024 CG ASP 268 67 .957 52. .809 38, .408 1. .00 50 .40 1SG2025
ATOM 2025 OD1 ASP 268 67 .252 51. .830 38. .772 1. .00 50, .40 1SG2026
ATOM 2026 OD2 ASP 268 67. .618 54. .013 38. .558 1. .00 50, .40 1SG2027
ATOM 2027 C ASP 268 68 .642 50. .725 36. .215 1. .00 50, .40 1SG2028
ATOM 2028 O ASP 268 69 .154 50. .182 35. .238 1. .00 50 .40 1SG2029
ATOM 2029 N ASP 269 67. .341 51, .086 36. .262 1. .00 51, .18 1SG2030
ATOM 2030 CA ASP 269 66. .340 50. .987 35. .231 1. .00 51 .18 1SG2031
ATOM 2031 CB ASP 269 66, .842 51. .510 33. .873 1. .00 51, .18 1SG2032
ATOM 2032 CG ASP 269 65, .655 51. .662 32. .930 1. .00 51, .18 1SG2033
ATOM 2033 OD1 ASP 269 64, .498 51. .473 33. .390 1. .00 51, .18 1SG2034
ATOM 2034 OD2 ASP 269 65. .893 51. .972 31, .732 1. .00 51, .18 1SG2035
ATOM 2035 C ASP 269 65, .955 49. .556 35. .064 1. .00 51, .18 1SG2036
ATOM 2036 O ASP 269 64, .897 9. .237 34. .523 1. .00 51, .18 1SG2037
ATOM 2037 N ASN 270 66, .776 48. .646 35. .600 1. .00 49, .06 1SG2038
ATOM 2038 CA ASN 270 66. .436 47. .262 35. .539 1. .00 49, .06 1SG2039
ATOM 2039 CB ASN 270 67. .253 46. .473 34. .502 1. .00 49. .06 1SG2040
ATOM 2040 CG ASN 270 66, .638 45. .089 34. .346 1. .00 49. .06 1SG2041
ATOM 2041 OD1 ASN 270 67. .118 44. ,271 33. ,562 1. .00 49. .06 1SG2042
ATOM 2042 ND2 ASN 270 65. .543 44. .816 35. .103 1. .00 49, .06 1SG2043
ATOM 2043 C ASN 270 66. .811 46. .753 36. ,881 1. ,00 49. .06 1SG2044
ATOM 2044 O ASN 270 67. .908 47. .028 37. ,364 1. .00 49. .06 1SG2045
ATOM 2045 N LEU 271 65. .901 46. .025 37. ,541 1. .00 44. .98 1SG2046
ATOM 2046 CA LEU 271 66. .259 45. ,552 38. ,838 1. .00 44. .98 1SG2047
ATOM 2047 CB LEU 271 65. ,467 46. .215 39. .978 1. .00 44. .98 1SG2048
ATOM 2048 CG LEU 271 65. .729 47. .728 40. ,103 1. ,00 44. .98 1SG2049
ATOM 2049 CD2 LEU 271 67. .234 48. 029 40. 205 1. 00 44. ,98 1SG2050 ATOM 2050 CD1 LEU 271 64.915 48.343 41.256 1.00 44.98 1SG2051
ATOM 2051 C LEU 271 65.967 44.098 38.883 1.00 44.98 1SG2052
ATOM 2052 O LEU 271 64.997 43.627 38.289. 1.00 44.98 1SG2053
ATOM 2053 N LEU 272 66.823 43.332 39.583 1.00 41.98 1SG2054
ATOM 2054 CA LEU 272 66.525 41.946 39.720 1.00 41.98 1SG2055
ATOM 2055 CB LEU 272 67.771 41.067 39.917 1.00 41.98 1SG2056
ATOM 2056 CG LEU 272 68.724 41.074 38.705 1.00 41.98 1SG2057
ATOM 2057 CD2 LEU 272 67.980 40.719 37.406 1.00 41.98 1SG2058
ATOM 2058 CD1 LEU 272 69.948 40.176 38.952 1.00 41.98 1SG2059
ATOM 2059 C LEU 272 65.719 41.875 40.967 1.00 41.98 1SG2060
ATOM 2060 O LEU 272 66.213 41.489 42.026 00 41.98 1SG2061
ATOM 2061 N ASN 273 64.441 42.274 40.860 00 39.83 1SG2062
ATOM 2062 CA ASN 273 63.573 42.269 41.994 00 39.83 1SG2063
ATOM 2063 CB ASN 273 63.390 43.661 42.624 00 39.83 1SG2064
ATOM 2064 CG ASN 273 62.802 43.492 44.019 00 39.83 1SG2065
ATOM 2065 OD1 ASN 273 63.530 43.489 45.010 00 39.83 1SG2066
ATOM 2066 ND2 ASN 273 61.454 43.348 44.106 00 39.83 1SG2067
ATOM 2067 C ASN 273 62.245 41.816 41.494 1.00 39.83 1SG2068
ATOM 2068 O ASN 273 61.913 41.999 40.326 00 39.83 1SG2069
ATOM 2069 N THR 274 61.446 41.209 42.382 00 39.08 1SG2070
ATOM 2070 CA THR 274 60.157 40.709 42.020 00 39.08 1SG2071
ATOM 2071 CB THR 274 59.449 40.114 43.191 00 39.08 1SG2072
ATOM 2072 OGl THR 274 60.186 39.017 43.707 00 39.08 1SG2073
ATOM 2073 CG2 THR 274 58.055 39.675 42.742 00 39.08 1SG2074
ATOM 2074 C THR 274 59.329 41.859 41.557 1.00 39.08 1SG2075
ATOM 2075 O THR 274 58.538 41.733 40.624 1.00 39.08 1SG2076
ATOM 2076 N SER 275 59.491 43.016 42.218 1.00 37.45 1SG2077
ATOM 2077 CA SER 275 58.703 44.168 41.907 1.00 37.45 1SG2078
ATOM 2078 CB SER 275 59.075 45.389 42.766 1.00 37.45 1SG2079 TOM 2079 OG SER 275 58.263 46.500 42.416 1.00 37.45 1SG2080
ATOM 2080 C SER 275 58.909 44.552 40.475 1.00 37.45 1SG2081
ATOM 2081 O SER 275 57.941 44.736 39.737 00 37.45 1SG2082
ATOM 2082 N ALA 276 60.179 44.675 40.034 00 35.94 1SG2083
ATOM 2083 CA ALA 276 60.448 45.086 38.681 00 35.94 1SG2084
ATOM 2084 CB ALA 276 61.952 45.203 38.387 00 35.94 1SG2085
ATOM 2085 C ALA 276 59.884 44.062 37.751 00 35.94 1SG2086
ATOM 2086 O ALA 276 59.241 44.396 36.758 00 35.94 1SG2087
ATOM 2087 N LEU 277 60.085 4 .775 38.079 00 37.24 1SG2088
ATOM 2088 CA LEU 277 59.592 41.691 37.280 00 37.24 1SG2089
ATOM 2089 CB LEU 277 60.016 40.294 37.770 00 37.24 1SG2090
ATOM 2090 CG LEU 277 61.453 39.904 37.365 00 37.24 1SG2091
ATOM 2091 CD2 LEU 277 61.760 38.451 37.760 00 37.24 1SG2092
ATOM 2092 CD1 LEU 277 62.500 40.895 37.892 1.00 37.24 1SG2093
ATOM 2093 C LEU 277 58.103 41.769 37.271 1.00 37.24 1SG2094
ATOM 2094 0 LEU 277 57.449 41.232 36.382 1.00 37.24 1SG2095
ATOM 2095 N GLY 278 57.527 42.429 38.286 1.00 40.43 1SG2096
ATOM 2096 CA GLY 278 56.106 42.558 38.416 1.00 40.43 1SG2097
ATOM 2097 C GLY 278 55.548 43.244 37.204 1.00 40.43 1SG2098
ATOM 2098 0 GLY 278 54.387 43.055 36.856 1.00 40.43 1SG2099
ATOM 2099 N ARG 279 56.307 44.133 36.549 1.00 51.98 1SG2100
ATOM 2100 CA ARG 279 55.691 44.728 35.398 1.00 51.98 1SG2101
ATOM 2101 CB ARG 279 56.599 45.758 34.705 1.00 51.98 1SG2102
ATOM 2102 CG ARG 279 56.867 47.007 35.547 1.00 51.98 1SG2103
ATOM 2103 CD ARG 279 55.789 48.083 35.406 1.00 51.98 1SG2104
ATOM 2104 NE ARG 279 55.813 48.557 33.993 1.00 51.98 1SG2105
ATOM 2105 CZ ARG 279 56.633 49.587 33.632 1.00 51.98 1SG2106
ATOM 2106 NH1 ARG 279 57.429 50.185 34.566 1.00 51.98 1SG2107 ATOM 2107 NH2 ARG 279 56..657 50..019 32..338 1..00 51..98 1SG2108
ATOM 2108 C ARG 279 55. .396 43. .647 34. .393 1. .00 51. .98 1SG2109
ATOM 2109 O ARG 279 54. .287 43. .562 33. 865 1. ,00 51. .98 1SG2110
ATOM 2110 N LEU 280 56. .411 42. .814 34. .091 1. .00 68. .43 1SG2111
ATOM 2111 CA LEU 280 56. .324 41. .751 33, .128 1. .00 68. .43 1SG2112
ATOM 2112 CB LEU 280 57, .721 41. .256 32, .714 1. .00 68. .43 1SG2113
ATOM 2113 CG LEU 280 58, .586 42. .321 32. .008 1. ,00 68. .43 1SG2114
ATOM 2114 CD2 LEU 280 59. .861 41, .698 31. .417 1. .00 68. .43 1SG2115
ATOM 2115 CD1 LEU 280 58 .893 43. .509 32. .935 1. .00 68. .43 1SG2116
ATOM 2116 C LEU 280 55, .558 40. .532 33, .570 1. .00 68. .43 1SG2117
ATOM 2117 O LEU 280 54, .647 40. .097 32. .865 1. .00 68. .43 1SG2118
ATOM 2118 N ILE 281 55. .916 39. .910 34. .723 1, .00 82 .54 1SG2119
ATOM 2119 CA ILE 281 55. .210 38. .690 34. .999 1. .00 82. .54 1SG2120
ATOM 2120 CB ILE 281 55. .908 37. .487 34, .435 1. .00 82. .54 1SG2121
ATOM 2121 CG2 ILE 281 55. .858 37. .634 32. .908 1. .00 82. .54 1SG2122
ATOM 2122 CGI ILE 281 57. .329 37. ,325 35, .003 1. ,00 82. .54 1SG2123
ATOM 2123 CD1 ILE 281 57. .962 35. .970 34 .687 1. .00 82. .54 1SG2124
ATOM 2124 C ILE 281 54. .903 38. .428 36, .442 1. .00 82, .54 1SG2125
ATOM 2125 O ILE 281 55, .678 37, .772 37, .138 1, .00 82, .54 1SG2126
ATOM 2126 N PRO 282 53, .819 38, ,937 36, .951 1. .00 91. .50 1SG2127
ATOM 2127 CA PRO 282 53, .433 38. .446 38 .242 1, .00 91, .50 1SG2128
ATOM 2128 CD PRO 282 53, .607 40. ,363 36, .852 1. .00 91, .50 1SG2129
ATOM 2129 CB PRO 282 52. .888 39, .623 39 .040 1, .00 91. .50 1SG2130
ATOM 2130 CG PRO 282 53. .442 40, .843 38, .305 1. .00 91. .50 1SG2131
ATOM 2131 C PRO 282 52. .345 37, .466 37 .986 1. .00 91, .50 1SG2132
ATOM 2132 O PRO 282 51 .349 37 .893 37 .400 1. .00 91 .50 1SG2133
ATOM 2133 N GLU 283 52. .418 36, .185 38 .383 1. .00 87, .70 1SG2134
ATOM 2134 CA GLU 283 53, .473 35. .405 38, .954 1. .00 87, .70 1SG2135
ATOM 2135 CB GLU 283 54. .338 34, .695 37, .905 1. .00 87, .70 1SG2136
ATOM 2136 CG GLU 283 55 .135 33 .549 38 .523 1. .00 87, .70 1SG2137
ATOM 2137 CD GLU 283 54. .137 32, .495 38, .991 1, .00 87, .70 1SG2138
ATOM 2138 OEl GLU 283 52. .908 32 , .724 38, .829 1, .00 87. .70 1SG2139
ATOM 2139 OE2 GLU 283 54. .591 31, .446 39 .521 1. .00 87 .70 1SG2140
ATOM 2140 C GLU 283 54 .371 36 .049 39 .960 1. .00 87 .70 1SG2141
ATOM 2141 O GLU 283 53. .991 36, .198 41, .116 1. .00 87. .70 1SG2142
ATOM 2142 N VAL 284 55. .602 36. ,425 39. .543 1. .00 72. .32 1SG2143
ATOM 2143 CA VAL 284 56. .680 36. .769 40, .438 1. .00 72. .32 1SG2144
ATOM 2144 CB VAL 284 57 .850 37, .389 39, .719 1, .00 72, .32 1SG2145
ATOM 2145 CGI VAL 284 58, .415 36, .358 38, .725 1. .00 72, .32 1SG2146
ATOM 2146 CG2 VAL 284 57 .406 38 .703 39 .054 1. .00 72, .32 1SG2147
ATOM 2147 C VAL 284 56, .236 37, .702 41. .518 1. .00 72, .32 1SG2148
ATOM 2148 O VAL 284 56 .493 37, .434 42. .692 1, .00 72, .32 1SG2149
ATOM 2149 N ALA 285 55. .556 38, .809 41, .183 1. .00 55. .92 1SG2150
ATOM 2150 CA ALA 285 55 .136 39, .690 42, .233 1. .00 55. .92 1SG2151
ATOM 2151 CB ALA 285 54, .472 40. .973 41, .704 1. .00 55. .92 1SG2152
ATOM 2152 C ALA 285 54 .131 38, .988 43, .099 1. .00 55. .92 1SG2153
ATOM 2153 O ALA 285 54 .191 39 .078 44, .323 1. .00 55. .92 1SG2154
ATOM 2154 N ARG 286 53 .167 38, .279 42, .476 1. .00 45. .05 1SG2155
ATOM 2155 CA ARG 286 52 , .104 37. .642 43, .206 1. .00 45. .05 1SG2156
ATOM 2156 CB ARG 286 51, .059 37. .014 42, .269 1. .00 45, .05 1SG2157
ATOM 2157 CG ARG 286 49 .909 36, .324 43 .003 1, .00 45, .05 1SG2158
ATOM 2158 CD ARG 286 48, .869 35, .702 42, .066 1. .00 45. .05 1SG2159
ATOM 2159 NE ARG 286 49. .571 34. .711 41. .204 1. . 00 45. .05 1SG2160
ATOM 2160 CZ ARG 286 50. .080 35. .098 39. .998 1. .00 45. .05 1SG2161
ATOM 2161 NH1 ARG 286 49, .948 36, .393 39. .587 1. .00 45. .05 1SG2162
ATOM 2162 NH2 ARG 286 50, .716 34. .191 39. .202 1. .00 45. .05 1SG2163
ATOM 2163 C ARG 286 52, .594 36. .548 44. .112 1. .00 45. ,05 1SG2164 ATOM 2164 O ARG 286 52.,305 36..553 45..307 1.,00 45..05 1SG2165
ATOM 2165 N GLN 287 53. .352 35. .578 43. .565 1. ,00 42. .28 1SG2166
ATOM 2166 CA GLN 287 53. .806 34. .446 44. .323 1, ,00 42. .28 1SG2Ϊ67
ATOM 2167 CB GLN 287 54. .493 33. .385 43, .448 1. .00 42. .28 1SG2168
ATOM 2168 CG GLN 287 54. .985 32. .170 44. .238 1. .00 42. ,28 1SG2169
ATOM 2169 CD GLN 287 55, .635 31. .203 43. .258 1. .00 42. .28 1SG2170
ATOM 2170 OEl GLN 287 56, .105 30. .133 43. .641 1. .00 42. .28 1SG2171
ATOM 2171 NE2 GLN 287 55, .667 31. .592 41. .955 1. .00 42. .28 1SG2172
ATOM 2172 C GLN 287 54. .800 34. .889 45. .339 1. .00 42. .28 1SG2173
ATOM 2173 O GLN 287 54, .721 34, .499 46. .503 1. .00 42. .28 1SG2174
ATOM 2174 N PHE 288 55, .768 35. .733 44 , .925 1. .00 47. .06 1SG2175
ATOM 2175 CA PHE 288 56, .744 36. .208 45, .860 1. .00 47. .06 1SG2176
ATOM 2176 CB PHE 288 58. .176 35. ,979 45. .364 1. .00 47. ,06 1SG2177
ATOM 2177 CG PHE 288 58. .358 34. .505 45. .252 1. .00 47. .06 1SG2178
ATOM 2178 CD1 PHE 288 58. .686 33. .753 46. .357 1. .00 47. .06 1SG2179
ATOM 2179 CD2 PHE 288 58, .196 33. .873 44. .040 1. .00 47. .06 1SG2180
ATOM 2180 CE1 PHE 288 58, .850 32 .392 46. .254 1. .00 47. .06 1SG2181
ATOM 2181 CE2 PHE 288 58, .359 32. .513 43 , .931 1. .00 47. .06 1SG2182
ATOM 2182 CZ PHE 288 58, .687 31. .770 45. .040 1. .00 47. .06 1SG2183
ATOM 2183 C PHE 288 56 .531 37, .682 45. .971 1. .00 47, .06 1SG2184
ATOM 2184 O PHE 288 57 .132 38 .468 45 .240 1, .00 47 .06 1SG2185
ATOM 2185 N PRO 289 55, .707 38, .064 46. .907 1. ,00 54. .14 1SG2186
ATOM 2186 CA PRO 289 55, .363 39, .453 47. .021 1. .00 54. .14 1SG2187
ATOM 2187 CD PRO 289 54 .578 37 .215 47 .256 1. .00 54 .14 1SG2188
ATOM 2188 CB PRO 289 54, .004 39 .511 47, .716 1. .00 54. .14 1SG2189
ATOM 2189 CG PRO 289 53, .372 38. .150 47, .402 1. .00 54. .14 1SG2190
ATOM 2190 C PRO 289 56 .376 40 .273 47 .730 1. .00 54, .14 1SG2191
ATOM 2191 O PRO 289 57, .212 39, .731 48, .450 1. .00 54, .14 1SG2192
ATOM 2192 N GLU 290 56 .294 41 .599 47 .535 1. .00 57 .07 1SG2193
ATOM 2193 CA GLU 290 57, .153 42. .509 48. .218 1. .00 57. .07 1SG2194
ATOM 2194 CB GLU 290 57, .290 42. .225 49, .724 1. .00 57. .07 1SG2195
ATOM 2195 CG GLU 290 55 .997 42 .458 50 .508 1. .00 57 .07 1SG2196
ATOM 2196 CD GLU 290 56 .270 42, .143 51, .971 1. .00 57, .07 1SG2197
ATOM 2197 OEl GLU 290 57, .427 41, .755 52, .287 1. .00 57, .07 1SG2198
ATOM 2198 OE2 GLU 290 55 .326 42 .286 52, .793 1. .00 57, .07 1SG2199
ATOM 2199 C GLU 290 58 .483 42, .422 47, .604 1. .00 57, .07 1SG2200
ATOM 2200 O GLU 290 58 .880 41 .361 47 .121 1. .00 57 .07 1SG2201
ATOM 2201 N PRO 291 59 .136 43 .562 47, .638 1. .00 5 .67 1SG2202
ATOM 2202 CA PRO 291 60, .435 43, .743 47, .065 1. .00 54, .67 1SG2203
ATOM 2203 CD PRO 291 58 .801 44 .611 48 .585 1. .00 54, .67 1SG2204
ATOM 2204 CB PRO 291 60 .970 45 .068 47 .608 1. .00 54 .67 1SG2205
ATOM 2205 CG PRO 291 59, .732 45 .771 48 .198 1. .00 54, .67 1SG2206
ATOM 2206 C PRO 291 61 .254 42 .595 47, .515 1. .00 54, .67 1SG2207
ATOM 2207 O PRO 291 61 .707 42 .568 48 .658 1. .00 54, .67 1SG2208
ATOM 2208 N MET 292 61 .434 41 .636 46, .601 1. .00 49. .83 1SG2209
ATOM 2209 CA MET 292 62 .168 40 .455 46 .883 1. .00 49. .83 1SG2210
ATOM 2210 CB MET 292 61, .357 39, .194 46. .555 1. ,00 49. .83 1SG2211
ATOM 2211 CG MET 292 61 .897 37 .895 47. .145 1. ,00 49. .83 1SG2212
ATOM 2212 SD MET 292 60 .910 36 .447 46 .672 1. .00 49, .83 1SG2213
ATOM 2213 CE MET 292 61 .341 35 .412 48. .095 1. ,00 49. .83 1SG2214
ATOM 2214 C MET 292 63, .276 40, .528 45, .906 1. ,00 49. .83 1SG2215
ATOM 2215 O MET 292 63 .058 40 .857 44, .741 1. .00 49, .83 1SG2216
ATOM 2216 N PRO 293 64, .462 40, .276 46. .347 1. .00 42. .69 1SG2217
ATOM 2217 CA PRO 293 65 .544 40, .332 45. .421 1. .00 42. .69 1SG2218
ATOM 2218 CD PRO 293 64, .877 40, .639 47 .689 1, .00 42 .69 1SG2219
ATOM 2219 CB PRO 293 66, .819 40, .488 46. .256 1. .00 42. .69 1SG2220
ATOM 2220 CG PRO 293 66 .366 40, .267 47. .712 1. ,00 42. .69 1SG2221 ATOM 2221 C RO 293 65,.491 39,.121 44,.564 1..00 42,.69 1SG2222
ATOM 2222 O PRO 293 64, .959 38, .100 44 .996 1. .00 42 .69 1SG2223
ATOM 2223 N VAL 294 66 .014 39 .224 43 .333 1. .00 37 .45 1SG2224
ATOM 2224 CA VAL 294 66, .026 38, .099 42, .456 1. .00 37, .45 1SG2225
ATOM 2225 CB VAL 294 65, .422 38, .391 41, .117 1. .00 37, .45 1SG2226
ATOM 2226 CGI VAL 294 65 .656 37, .176 40 .208 1, .00 37 .45 1SG2227
ATOM 2227 CG2 VAL 294 63 .939 38 .751 41 .315 1. .00 37 .45 1SG2228
ATOM 2228 C VAL 294 67, .464 37, .780 42, .225 1. .00 37, .45 1SG2229
ATOM 2229 O VAL 294 68, .287 38, .681 42 .068 1. .00 37, .45 1SG2230
ATOM 2230 N VAL 295 67, .805 36 .478 42 .222 1, .00 35 .34 1SG2231
ATOM 2231 CA VAL 295 69, .160 36 .084 41 .984 1. .00 35 .34 1SG2232
ATOM 2232 CB VAL 295 69. .729 35, .208 43, .060 1. .00 35, .34 1SG2233
ATOM 2233 CGI VAL 295 68. .918 33, .902 43, .106 1. .00 35, .34 1SG2234
ATOM 2234 CG2 VAL 295 71. .227 34 .997 42 .778 1, .00 35 .34 1SG2235
ATOM 2235 C VAL 295 69 .148 35 .290 40 .722 1. .00 35 .34 1SG2236
ATOM 2236 O VAL 295 68 .243 34 .488 40 .496 1 .00 35 .34 1SG2237
ATOM 2237 N LEU 296 70. .152 35, .509 39 .852 1, .00 35 .73 1SG2238
ATOM 2238 CA LEU 296 70. .168 34, .811 38 .602 1, .00 35 .73 1SG2239
ATOM 2239 CB LEU 296 70, .136 35 .779 37 .403 1. .00 35 .73 1SG2240
ATOM 2240 CG LEU 296 69 .943 35 .120 36 .025 1 .00 35 .73 1SG2241
ATOM 2241 CD2 LEU 296 68, .580 34. .414 35 .957 1. .00 35 .73 1SG2242
ATOM 2242 CD1 LEU 296 71, .129 34. .224 35 .629 1. .00 35 .73 1SG2243
ATOM 2243 C LEU 296 71, .434 34 .010 38 .545 1. .00 35 .73 1SG2244
ATOM 2244 O LEU 296 72, .503 34 .481 38 .932 1. .00 35 .73 1SG2245
ATOM 2245 N LYS 297 71, .337 32. .758 38, .054 1. .00 37, .89 1SG2246
ATOM 2246 CA LYS 297 72, .488 31, .906 37 .963 1. .00 37 .89 1SG2247
ATOM 2247 CB LYS 297 72, .237 30, .505 38 .550 1, .00 37 .89 1SG2248
ATOM 2248 CG LYS 297 73, .462 29 .586 38 .564 1. .00 37 .89 1SG2249
ATOM 2249 CD LYS 297 74 , .500 29, .945 39 .629 1, .00 37, .89 1SG2250
ATOM 2250 CE LYS 297 75, .335 31, .178 39, .289 1. .00 37, .89 1SG2251
ATOM 2251 NZ LYS 297 76, .307 31, .445 40 .374 1. .00 37 .89 1SG2252
ATOM 2252 C LYS 297 72, .792 31 .716 36 .510 1, .00 37 .89 1SG2253
ATOM 2253 O LYS 297 71. .917 31. .358 35, .724 1. .00 37, .89 1SG2254
ATOM 2254 N VAL 298 74. .056 31. .961 36. .113 1. .00 38, .46 1SG2255
ATOM 2255 CA VAL 298 74. .425 31, .782 34 .740 1. .00 38, .46 1SG2256
ATOM 2256 CB VAL 298 75. .021 33, .017 34 .124 1, .00 38 .46 1SG2257
ATOM 2257 CGI VAL 298 75. .497 32. .681 32. .700 1. .00 38, .46 1SG2258
ATOM 2258 CG2 VAL 298 73. .978 34. .145 34. .186 1. .00 38, .46 1SG2259
ATOM 2259 C VAL 298 75, .473 30. .719 34. .700 1. .00 38, .46 1SG2260
ATOM 2260 0 VAL 298 76. .503 30. .819 35. .366 1. .00 38 .46 1SG2261
ATOM 2261 N ARG 299 75. .231 29. .658 33. .908 1. .00 39, .54 1SG2262
ATOM 2262 CA ARG 299 76. .195 28. .605 33. .803 1. .00 39, .54 1SG2263
ATOM 2263 CB ARG 299 75. .861 27. .370 34. .658 1. .00 39, .54 1SG2264
ATOM 2264 CG ARG 299 76. .885 26. .236 34, .550 1. .00 39, .54 1SG2265
ATOM 2265 CD ARG 299 78. .203 26. .512 35. .274 1. ,00 39. .54 1SG2266
ATOM 2266 NE ARG 299 77. ,996 26. .220 36. .721 1. ,00 39. .54 1SG2267
ATOM 2267 CZ ARG 299 78. .180 24. .953 37. .196 1. ,00 39. .54 1SG2268
ATOM 2268 NH1 ARG 299 78. .542 23. .949 36, .343 1. ,00 39. .54 1SG2269
ATOM 2269 NH2 ARG 299 78. .005 24. .690 38. .524 1. ,00 39. .54 1SG2270
ATOM 2270 C ARG 299 76. ,221 28. .178 32. .375 1. ,00 39. .54 1SG2271
ATOM 2271 O ARG 299 75. .307 28. .467 31. .606 1. ,00 39. .54 1SG2272
ATOM 2272 N LEU 300 77. .300 27. .483 31. .985 1. ,00 37. .39 1SG2273
ATOM 2273 CA LEU 300 77. .454 27. .050 30. .633 1. ,00 37. .39 1SG2274
ATOM 2274 CB LEU 300 78. .936 27. .128 30. .222 1. 00 37. .39 1SG2275
ATOM 2275 CG LEU 300 79. ,288 26. .520 28. ,865 1. .00 37. .39 1SG2276
ATOM 2276 CD2 LEU 300 78. ,361 27. ,022 27. .746 1. 00 37. .39 1SG2277
ATOM 2277 CD1 LEU 300 79. .318 25. .000 28. .993 1. 00 37. .39 1SG2278 ATOM 2278 C LEU 300 76..909 25.,657 30..526 1.00 37.39 1SG2279
ATOM 2279 O LEU 300 77. .337 24. .751 31. .240 1. .00 37. .39 1SG2280
ATOM 2280 N GLY 301 75. .904 25. .475 29. .643 1. .00 35. .15 1SG2281
ATOM 2281 CA GLY 301 75. .267 24. .203 29. .438 1. ,00 35. ,15 1SG2282
ATOM 2282 C GLY 301 76. .183 23. .216 28. .775 1. ,00 35. ,15 1SG2283
ATOM 2283 O GLY 301 76. ,281 22. .070 29. .213 1. .00 35. .15 1SG2284
ATOM 2284 N ALA 302 76. .874 23. .628 27. .690 1. .00 35. .49 1SG2285
ATOM 2285 CA ALA 302 77. .713 22. .703 26. .976 1. .00 35. .49 1SG2286
ATOM 2286 CB ALA 302 77. .050 22. .112 25. ,719 1. .00 35. .49 1SG2287
ATOM 2287 C ALA 302 78. .932 23. .441 26. .526 1. ,00 35. .49 1SG2288
ATOM 2288 O ALA 302 78, .895 24. .654 26. .337 1. .00 35. .49 1SG2289
ATOM 2289 N THR 303 80, .049 22, .714 26. .324 1. .00 34. .96 1SG2290
ATOM 2290 CA THR 303 81. .301 23. .339 26, .001 1. .00 34, .96 1SG2291
ATOM 2291 CB THR 303 82, .392 22. .353 25. .701 1. .00 34, .96 1SG2292
ATOM 2292 OGl THR 303 82, .052 21. .579 24. .561 1. .00 34. .96 1SG2293
ATOM 2293 CG2 THR 303 82, .577 21. .440 26. .925 1. .00 34, .96 1SG2294
ATOM 2294 C THR 303 81. .129 24. .223 24, .810 1. .00 34, .96 1SG2295
ATOM 2295 O THR 303 80. .540 23 , .853 23, .796 1. .00 34, .96 1SG2296
ATOM 2296 N PRO 304 81 .650 25. .413 24, .946 1. .00 36, .41 1SG2297
ATOM 2297 CA PRO 304 81. .531 26. .378 23. .890 1. .00 36, .41 1SG2298
ATOM 2298 CD PRO 304 81 .729 26 .044 26 .254 1. .00 36 .41 1SG2299
ATOM 2299 CB PRO 304 81 .936 27. .717 24, .500 1. .00 36. .41 1SG2300
ATOM 2300 CG PRO 304 81. .584 27. .553 25. .990 1. .00 36, .41 1SG2301
ATOM 2301 C PRO 304 82 .345 25 .961 22. .711 1. .00 36, .41 1SG2302
ATOM 2302 O PRO 304 8 .368 25 .300 22, .882 1. .00 36, .41 1SG2303
ATOM 2303 N VAL 305 81. .904 26. .324 21, .496 1. .00 36, .36 1SG2304
ATOM 2304 CA VAL 305 82 .640 25 .926 20 .337 1. .00 36, .36 1SG2305
ATOM 2305 CB VAL 305 81 .808 25, .193 19, .327 1. .00 36. .36 1SG2306
ATOM 2306 CGI VAL 305 81 .313 23 .881 19 .960 1. .00 36. .36 1SG2307
ATOM 2307 CG2 VAL 305 80 .675 26 .123 18, .861 1, .00 36. .36 1SG2308
ATOM 2308 C VAL 305 83 .154 27, .159 19, .678 1. .00 36, .36 1SG2309
ATOM 2309 O VAL 305 82 .520 28 .211 19, .726 1. .00 36, .36 1SG2310
ATOM 2310 N ALA 306 84 .352 27 .057 19, .069 1. .00 34, .52 1SG2311
ATOM 2311 CA ALA 306 8 .919 28, .169 18, .368 1, .00 34 .52 1SG2312
ATOM 2312 CB ALA 306 86 .234 28 .677 18 .982 1. .00 34, .52 1SG2313
ATOM 2313 C ALA 306 85 .232 27 .682 16, .991 1. .00 34, .52 1SG2314
ATOM 2314 O ALA 306 85 .812 26 .610 16 .818 1. .00 34 .52 1SG2315
ATOM 2315 N MET 307 84 .851 28 .467 15 .966 1 .00 33 .03 1SG2316
ATOM 2316 CA MET 307 85. .106 28. .050 14, .619 1. .00 33, .03 1SG2317
ATOM 2317 CB MET 307 83 .852 28 .052 13 .727 1, .00 33, .03 1SG2318
ATOM 2318 CG MET 307 8 .824 26, .991 14, .124 1. .00 33, .03 1SG2319
ATOM 2319 SD MET 307 81 .332 26 .972 13 .087 1. .00 33 .03 1SG2320
ATOM 2320 CE MET 307 80 .660 28 .500 13, .801 1. .00 33, .03 1SG2321
ATOM 2321 C MET 307 86, .078 29, .015 14, .026 1. .00 33, .03 1SG2322
ATOM 2322 0 MET 307 85 .941 30 .227 14 .185 1. .00 33 .03 1SG2323
ATOM 2323 N LEU 308 87 .106 28 .491 13 .332 1. .00 31 .92 1SG2324
ATOM 2324 CA LEU 308 88, .080 29, .357 12, .735 1. .00 31, .92 1SG2325
ATOM 2325 CB LEU 308 89 .534 28 .935 13, .012 1. .00 31, .92 1SG2326
ATOM 2326 CG LEU 308 89, .936 29, .007 14, .498 1. .00 31, .92 1SG2327
ATOM 2327 CD2 LEU 308 89 .075 28 .067 15 .356 1, .00 31, .92 1SG2328
ATOM 2328 CD1 LEU 308 89 .934 30, .456 15 .010 1. .00 31, .92 1SG2329
ATOM 2329 C LEU 308 87, .890 29, .316 11, .253 1. .00 31. .92 1SG2330
ATOM 2330 0 LEU 308 87 .890 28 .245 10, .646 1. .00 31. .92 1SG2331
ATOM 2331 N HIS 309 87 .721 30 .502 10 .632 1. .00 30 .96 1SG2332
ATOM 2332 CA HIS 309 87, .532 30 .560 9 .214 1. .00 30. .96 1SG2333
ATOM 2333 ND1 HIS 309 84, .492 29, .656 10, .531 1. .00 30. .96 1SG2334
ATOM 2334 CG HIS 309 85, .207 29, .568 9, .356 1. ,00 30. .96 1SG2335 ATOM 2335 CB HIS 309 86.053 30.679 8..804 1..00 30.96 1SG2336
ATOM 2336 NE2 HIS 309 84 .129 27, .617 9 .724 1. .00 30 .96 1SG2337
ATOM 2337 CD2 HIS 309 84 .972 28 .313 8 .878 1. .00 30 .96 1SG2338
ATOM 2338 CE1 HIS 309 83 .867 28 .465 10 .704 1, .00 30 .96 1SG2339
ATOM 2339 C HIS 309 88 .252 31 .779 8 .719 1, .00 30 .96 1SG2340
ATOM 2340 O HIS 309 88 .729 32 .600 9 .501 1, .00 30 .96 1SG2341
ATOM 2341 N THR 310 88 .334 31, .918 7 .383 1, .00 30 .66 1SG2342
ATOM 2342 CA THR 310 89 .041 32, .985 6 .736 1, .00 30 .66 1SG2343
ATOM 2343 CB THR 310 88 .989 32, .880 5 .240 1. .00 30 .66 1SG2344
ATOM 2344 OGl THR 310 87 .650 33, .011 4 .787 1, .00 30 .66 1SG2345
ATOM 2345 CG2 THR 310 89 .551 31, .507 4. .830 1, .00 30 .66 1SG2346
ATOM 2346 C THR 310 88 .418 34, .293 7, .107 1. .00 30, .66 1SG2347
ATOM 2347 O THR 310 89 .104 35, .308 7 .213 1. .00 30 .66 1SG2348
ATOM 2348 N ASN 311 87 .082 34. .337 7, .255 1, .00 31 .80 1SG2349
ATOM 2349 CA ASN 311 86 .501 35, .600 7, .604 1, .00 31 .80 1SG2350
ATOM 2350 CB ASN 311 84 .967 35, .620 7, .531 1, .00 31 .80 1SG2351
ATOM 2351 CG ASN 311 84 .552 37, .077 7, .686 1. .00 31 .80 1SG2352
ATOM 2352 OD1 ASN 311 84. .681 37, .659 8. .762 1. .00 31, .80 1SG2353
ATOM 2353 ND2 ASN 311 84 .063 37, .692 6, .576 1, .00 31 .80 1SG2354
ATOM 2354 C ASN 311 86, .906 35, .978 8, ,999 1, .00 31, .80 1SG2355
ATOM 2355 O ASN 311 87, .351 37, .100 9, .235 1. .00 31, .80 1SG2356
ATOM 2356 N ASN 312 86, .761 35, .050 9, .969 1. .00 33, .01 1SG2357
ATOM 2357 CA ASN 312 87, .142 35. .369 11, .318 1. .00 33, .01 1SG2358
ATOM 2358 CB ASN 312 86 .477 36. .644 11 .873 1. .00 33 .01 1SG2359
ATOM 2359 CG ASN 312 87 .280 37. .114 13 .085 1. .00 33 .01 1SG2360
ATOM 2360 OD1 ASN 312 88 .449 37. .479 12 .970 1. .00 33 .01 1SG2361
ATOM 2361 ND2 ASN 312 86 .639 37. .087 14 .285 1. .00 33 .01 1SG2362
ATOM 2362 C ASN 312 86 .745 34. .210 12 .183 1. .00 33 .01 1SG2363
ATOM 2363 O ASN 312 86 .328 33, .168 11, .679 1. .00 33 .01 1SG2364
ATOM 2364 N ALA 313 86 .880 34, .363 13 .518 1. .00 36 .08 1SG2365
ATOM 2365 CA ALA 313 86 .557 33, .303 14 , .424 1, .00 36 .08 1SG2366
ATOM 2366 CB ALA 313 87 .589 33, .129 15, .551 1, .00 36 .08 1SG2367
ATOM 2367 C ALA 313 85 .245 33, .610 15, .066 1. .00 36 .08 1SG2368
ATOM 2368 O ALA 313 84 .972 34, .746 15, .455 1, .00 36 .08 1SG2369
ATOM 2369 N THR 314 84 .390 32, .577 15, .185 1. .00 40 .97 1SG2370
ATOM 2370 CA THR 314 83, .102 32, .768 15, .777 1. .00 40 .97 1SG2371
ATOM 2371 CB THR 314 81, .978 32. .341 14 , .882 1. .00 40 .97 1SG2372
ATOM 2372 OGl THR 314 82 .038 33, .041 13 , .649 1. .00 40, .97 1SG2373
ATOM 2373 CG2 THR 314 80, .655 32, .658 15, .589 1. .00 40, .97 1SG2374
ATOM 2374 C THR 314 83, .048 31. .905 17, .000 1. .00 40, .97 1SG2375
ATOM 2375 O THR 314 83, .644 30. .830 17. .037 1. .00 40, .97 1SG2376
ATOM 2376 N LEU 315 82, .342 32. .373 18. .049 1. .00 44 , .75 1SG2377
ATOM 2377 CA LEU 315 82, .232 31. .615 19. .263 1. ,00 44. .75 1SG2378
ATOM 2378 CB LEU 315 82, .741 32. .396 20. .499 1. .00 44. .75 1SG2379
ATOM 2379 CG LEU 315 82. .836 31. .635 21. .846 1. ,00 44. .75 1SG2380
ATOM 2380 CD2 LEU 315 81. .515 30. ,974 22. .275 1. ,00 44. .75 1SG2381
ATOM 2381 CD1 LEU 315 83. .359 32. .572 22. .947 1. .00 44. .75 1SG2382
ATOM 2382 C LEU 315 80, .780 31. .313 19. .450 1. .00 44. .75 1SG2383
ATOM 2383 O LEU 315 79, .930 32. .178 19, .244 1. .00 44. .75 1SG2384
ATOM 2384 N ARG 316 80, .452 30. .057 19, .827 1. .00 48, .35 1SG2385
ATOM 2385 CA ARG 316 79, .073 29. .725 20. .045 1. .00 48. .35 1SG2386
ATOM 2386 CB ARG 316 78, .597 28. .526 19. .211 1. .00 48. .35 1SG2387
ATOM 2387 CG ARG 316 77, .128 28. .169 19. .444 1. ,00 48. .35 1SG2388
ATOM 2388 CD ARG 316 76. .695 26. .892 18. .721 1. .00 48. .35 1SG2389
ATOM 2389 NE ARG 316 77. .377 25. ,749 19. .392 1. ,00 48. .35 1SG2390
ATOM 2390 CZ ARG 316 77. .197 24. .478 18. .929 1. ,00 48. .35 1SG2391
ATOM 2391 NH1 ARG 316 76. .387 24. .255 17. .853 1. 00 48. .35 1SG2392 ATOM 2392 NH2 ARG 316 77..828 23..430 19..537 1..00 48.,35 1SG2393
ATOM 2393 C ARG 316 78. .914 29. .343 21, .483 1. .00 48. .35 1SG2394
ATOM 2394 O ARG 316 79. .254 28. .234 21. .887 1. ,00 48. .35 1SG2395
ATOM 2395 N LEU 317 78. .358 30. .251 22. .303 1. ,00 50. .58 1SG2396
ATOM 2396 CA LEU 317 78, .190 29. .914 23. .684 1. .00 50. .58 1SG2397
ATOM 2397 CB LEU 317 78, .741 30. .985 24, .651 1. .00 50. .58 1SG2398
ATOM 2398 CG LEU 317 78. .165 32. .404 24. .468 1. ,00 50. .58 1SG2399
ATOM 2399 CD2 LEU 317 79. .057 33. .451 25. .153 1. .00 50. .58 1SG2400
ATOM 2400 CD1 LEU 317 76, .696 32. .495 24. .911 1. .00 50. .58 1SG2401
ATOM 2401 C LEU 317 76. .735 29. .705 23. .952 1. .00 50. .58 1SG2402
ATOM 2402 O LEU 317 75, .882 30. .377 23, .374 1. .00 50. .58 1SG2403
ATOM 2403 N GLN 318 76, .414 28. .715 24, .815 1. .00 49, .33 1SG2404
ATOM 2404 CA GLN 318 75, .046 28. .476 25. .173 1. .00 49. .33 1SG2405
ATOM 2405 CB GLN 318 74, .465 27. .178 24, .576 1. .00 49, .33 1SG2406
ATOM 2406 CG GLN 318 75, .148 25. .894 25, .051 1. .00 49. .33 1SG2407
ATOM 2407 CD GLN 318 74, .458 24. .719 24, .371 1. .00 49, .33 1SG2408
ATOM 2408 OEl GLN 318 74, .282 24. .706 23, .155 1. .00 49, .33 1SG2409
ATOM 2409 NE2 GLN 318 74, .047 23, .705 25. .180 1. .00 49, .33 1SG2410
ATOM 2410 C GLN 318 74 .973 28, .391 26 .669 1. .00 49 .33 1SG2411
ATOM 2411 O GLN 318 75, .477 27, .451 27. .283 1. .00 49, .33 1SG2412
ATOM 2412 N PRO 319 74, .421 29, .416 27. .267 1. .00 47, .24 1SG2413
ATOM 2413 CA PRO 319 74 .282 29 .402 28. .703 1, .00 47 .24 1SG2414
ATOM 2414 CD PRO 319 74, .761 30, .744 26, .780 1. .00 47, .24 1SG2415
ATOM 2415 CB PRO 319 74, .670 30, .800 29, .186 1. .00 47, .24 1SG2416
ATOM 2416 CG PRO 319 74 .477 31, .692 27, .951 1. .00 47 .24 1SG2417
ATOM 2417 C PRO 319 72 .921 29, .013 29, .189 1. .00 47. .24 1SG2418
ATOM 2418 O PRO 319 71, .956 29, .118 28, .431 1. .00 47, .24 1SG2419
ATOM 2419 N PHE 320 72 .812 28 .591 30 .468 1. .00 43 .41 1SG2420
ATOM 2420 CA PHE 320 71 .501 28, .403 31, .003 1. .00 43 .41 1SG2421
ATOM 2421 CB PHE 320 71, .141 26, .985 31, .500 1, .00 43 .41 1SG2422
ATOM 2422 CG PHE 320 71 .943 26, .565 32 .680 1, .00 43 .41 1SG2423
ATOM 2423 CD1 PHE 320 71 .496 26, .841 33, .952 1. .00 43 .41 1SG2424
ATOM 2424 CD2 PHE 320 73 .126 25 .882 32 .519 1. .00 43 .41 1SG2425
ATOM 2425 CE1 PHE 320 72 .221 26, .447 35 .051 1. .00 43 .41 1SG2426
ATOM 2426 CE2 PHE 320 73 .853 25, .484 33, .615 1. .00 43 .41 1SG2427
ATOM 2427 CZ PHE 320 73 .402 25 .767 34 .882 1. .00 43 .41 1SG2428
ATOM 2428 C PHE 320 71 .376 29, .395 32 .110 1. .00 43 .41 1SG2429
ATOM 2429 O PHE 320 72 .221 29. .472 33, .001 1. .00 43 .41 1SG2430
ATOM 2430 N VAL 321 70 .313 30, .215 32 .039 1. .00 38 .42 1SG2431
ATOM 2431 CA VAL 321 70 .111 31, .275 32, .978 1. .00 38 .42 1SG2432
ATOM 2432 CB VAL 321 69, .848 32, .570 32. .256 1. .00 38, .42 1SG2433
ATOM 2433 CGI VAL 321 69 .478 33. .673 33, .253 1, .00 38 .42 1SG2434
ATOM 2434 CG2 VAL 321 71 .084 32. .900 31, .402 1. .00 38, .42 1SG2435
ATOM 2435 C VAL 321 68, .903 30. .930 33. .788 1. .00 38, .42 1SG2436
ATOM 2436 O VAL 321 67 .816 30. .753 33, .242 1. .00 38 .42 1SG2437
ATOM 2437 N GLU 322 69 .058 30. .821 35, .125 1. .00 35. .12 1SG2438
ATOM 2438 CA GLU 322 67 .905 30, .509 35, .918 1. .00 35, .12 1SG2439
ATOM 2439 CB GLU 322 67 .993 29, .206 36, .733 1. .00 35, .12 1SG2440
ATOM 2440 CG GLU 322 69, .011 29, .243 37, .871 1. .00 35, .12 1SG2441
ATOM 2441 CD GLU 322 68 .768 28, .017 38 .741 1. .00 35 .12 1SG2442
ATOM 2442 OEl GLU 322 67 .730 27, .335 38, .526 1. .00 35, .12 1SG2443
ATOM 2443 OE2 GLU 322 69, .615 27. .747 39, .633 1. .00 35, .12 1SG2444
ATOM 2444 C GLU 322 67 .701 31. .617 36 .898 1. .00 35 .12 1SG2445
ATOM 2445 O GLU 322 68 .652 32. .137 37, .480 1. .00 35, .12 1SG2446
ATOM 2446 N VAL 323 66, .427 32. .000 37. .100 1. .00 32, .72 1SG2447
ATOM 2447 CA VAL 323 66 .104 33. .072 37. .993 1. .00 32 .72 1SG2448
ATOM 2448 CB VAL 323 65, .068 33. .997 37. .428 1. .00 32, .72 1SG2449 ATOM 2449 CGI VAL 323 64,.640 34..988 38,.520 1..00 32..72 1SG2450
ATOM 2450 CG2 VAL 323 65. .646 34. .665 36, .169 1. .00 32. .72 1SG2451
ATOM 2451 C VAL 323 65. .536 32. .483 39, .240 1. .00 32. .72 1SG2452
ATOM 2452 O VAL 323 64, .726 31. .559 39, .195 1. .00 32. .72 1SG2453
ATOM 2453 N LEU 324 65, .974 33, .008 40, .402 1. .00 31. .81 1SG2454
ATOM 2454 CA LEU 324 65. .490 32. .532 41, .661 1. .00 31, .81 1SG2455
ATOM 2455 CB LEU 324 66. .580 31. .870 42, .522 1. .00 31, .81 1SG2456
ATOM 2456 CG LEU 324 67. .195 30. .612 41, .880 1, .00 31, .81 1SG2457
ATOM 2457 CD2 LEU 324 66. .110 29, .604 41, .471 1. .00 31, .81 1SG2458
ATOM 2458 CD1 LEU 324 68. .272 29. .991 42, .786 1. .00 31, .81 1SG2459
ATOM 2459 C LEU 324 64. .993 33. .714 42, .427 1. .00 31, .81 1SG2460
ATOM 2460 O LEU 324 65, .457 34. .836 42, .233 1. .00 31 .81 1SG2461
ATOM 2461 N ALA 325 64. .011 33. .487 43, .318 1. .00 32, .43 1SG2462
ATOM 2462 CA ALA 325 63. .527 34. .557 44, .137 1. ,00 32 .43 1SG2463
ATOM 2463 CB ALA 325 61. .996 34. .578 44 .291 1. .00 32, .43 1SG2464
ATOM 2464 C ALA 325 64, .123 34. .314 45, .481 1. , 00 32 .43 1SG2465
ATOM 2465 O ALA 325 64. .166 33. ,179 45 .953 1. .00 32, .43 1SG2466
ATOM 2466 N THR 326 64. .622 35, .378 46, .135 1. .00 34, .29 1SG2467
ATOM 2467 CA THR 326 65. .256 35. .166 47 .404 1. .00 34 .29 1SG2468
ATOM 2468 CB THR 326 66, .435 36, .064 47, .639 1. ,00 34, .29 1SG2469
ATOM 2469 OGl THR 326 66. .019 37. .421 47 .658 1. .00 34, .29 1SG2470
ATOM 2470 CG2 THR 326 67. .458 35. .839 46, .513 1. .00 34. .29 1SG2471
ATOM 2471 C THR 326 64, .263 35. .445 48 .483 1, .00 34 .29 1SG2472
ATOM 2472 O THR 326 63 .776 36 .564 48 .633 1. .00 34 .29 1SG2473
ATOM 2473 N ALA 327 63, .951 34. .407 49 .279 1. .00 35 .97 1SG2474
ATOM 2474 CA ALA 327 63 .006 34 .514 50 .352 1. . 00 35 .97 1SG2475
ATOM 2475 CB ALA 327 62. .585 33 .157 50 .941 1. .00 35 .97 1SG2476
ATOM 2476 C ALA 327 63, .612 35 .329 51 .452 1. .00 35 .97 1SG2477
ATOM 2477 O ALA 327 64, .815 35. .584 51 .466 1, .00 35 .97 1SG2478
ATOM 2478 N SER 328 62, .763 35 .747 52 .415 1, .00 36 .93 1SG2479
ATOM 2479 CA SER 328 63, .150 36. .610 53 .498 1. .00 36 .93 1SG2480
ATOM 2480 CB SER 328 62, .035 36 .791 54 .543 1. .00 36 .93 1SG2481
ATOM 2481 OG SER 328 60, .918 37. .443 53 .957 1. .00 36 .93 1SG2482
ATOM 2482 C SER 328 64. .323 36 .009 54 .191 1. .00 36 .93 1SG2483
ATOM 2483 O SER 328 65. .199 36, .723 54 .679 1. .00 36 .93 1SG2484
ATOM 2484 N ASN 329 64. .390 34 .671 54 .243 1. .00 38 .88 1SG2485
ATOM 2485 CA ASN 329 65. .568 34. .090 54 .806 1. .00 38 .88 1SG2486
ATOM 2486 CB ASN 329 65. .379 32, .635 55 .287 1. .00 38 .88 1SG2487
ATOM 2487 CG ASN 329 64, .889 31, .759 54 .144 1. , 00 38 .88 1SG2488
ATOM 2488 OD1 ASN 329 64. .541 32, .243 53 .068 1. .00 38, .88 1SG2489
ATOM 2489 ND2 ASN 329 64. .840 30, .423 54, .392 1. .00 38, .88 1SG2490
ATOM 2490 C ASN 329 66. .541 34. .170 53 .679 1. .00 38, .88 1SG2491
ATOM 2491 O ASN 329 66. .722 35. .241 53. .107 1. ,00 38. .88 1SG2492
ATOM 2492 N SER 330 67. .248 33. .089 53, .336 1. .00 38. .85 1SG2493
ATOM 2493 CA SER 330 68, .083 33. .247 52, .187 1. ,00 38. .85 1SG2494
ATOM 2494 CB SER 330 69, .580 33, .216 52 .529 1, .00 38 .85 1SG2495
ATOM 2495 OG SER 330 70 .353 33 .380 51 .351 1. .00 38, .85 1SG2496
ATOM 2496 C SER 330 67, .792 32, .077 51 .311 1. .00 38, .85 1SG2497
ATOM 2497 O SER 330 68. .642 31 .623 50 .548 1. .00 38, .85 1SG2498
ATOM 2498 N ALA 331 66. .546 31, .577 51 .384 1. .00 39, .43 1SG2499
ATOM 2499 CA ALA 331 66. .179 30 .440 50 .596 1. .00 39, .43 1SG2500
ATOM 2500 CB ALA 331 64, .868 29, .776 51, .050 1. .00 39, .43 1SG2501
ATOM 2501 C ALA 331 65. .989 30 .913 49 .196 1. ,00 39, .43 1SG2502
ATOM 2502 O ALA 331 65, .657 32, .075 48, .964 1. ,00 39, .43 1SG2503
ATOM 2503 N PHE 332 66. .213 30. .017 48 .217 1. .00 42. .55 1SG2504
ATOM 2504 CA PHE 332 66. .044 30, .411 46, .852 1. 00 42. .55 1SG2505
ATOM 2505 CB PHE 332 67. .272 30. .119 45, .971 1. .00 42. .55 1SG2506 ATOM 2506 CG PHE 332 67..469 28..643 45.948 1.,00 42..55 1SG2507
ATOM 2507 CD1 PHE 332 68. ,144 28. .012 46. .968 1. ,00 42. .55 1SG2508
ATOM 2508 CD2 PHE 332 66. .981 27. .889 44. .906 1. .00 42. .55 1SG2509
ATOM 2509 CE1 PHE 332 68. .327 26. .649 46. .949 1. .00 42. .55 1SG2510
ATOM 2510 CE2 PHE 332 67. .161 26. .526 44. .882 1. .00 42 .55 1SG2511
ATOM 2511 CZ PHE 332 67. .835 25. .903 45. .905 1. ,00 42, .55 1SG2512
ATOM 2512 C PHE 332 64. .899 29, .632 46. .290 1. ,00 42, .55 1SG2513
ATOM 2513 O PHE 332 64. .789 28, .426 46. .507 1. .00 42, .55 1SG2514
ATOM 2514 N GLN 333 63, .998 30, .317 45, .556 1. .00 46 .69 1SG2515
ATOM 2515 CA GLN 333 62. .890 29, .629 44. .960 1. .00 46, .69 1SG2516
ATOM 2516 CB GLN 333 61. .522 30, .216 45. .360 1. .00 46, .69 1SG2517
ATOM 2517 CG GLN 333 60, .325 29, .308 45. .054 1. .00 46, .69 1SG2518
ATOM 2518 CD GLN 333 60, .174 29, .157 43. .548 1. .00 46 .69 1SG2519
ATOM 2519 OEl GLN 333 60, .426 28 .084 43. .003 1. .00 46 .69 1SG2520
ATOM 2520 NE2 GLN 333 59. .762 30, .252 42. .856 1. ,00 46, .69 1SG2521
ATOM 2521 C GLN 333 63, .045 29, .799 43. .478 1. .00 46, .69 1SG2522
ATOM 2522 O GLN 333 63. .141 30, .923 42, .988 1. .00 46 .69 1SG2523
ATOM 2523 N SER 334 63. .072 28, .678 42, .722 1. .00 51 .01 1SG2524
ATOM 2524 CA SER 334 63. .289 28, .752 41, .299 1. .00 51, .01 1SG2525
ATOM 2525 CB SER 334 63. .547 27, .398 40, .618 1. .00 51 .01 1SG2526
ATOM 2526 OG SER 334 64 , .865 26, .954 40, .888 1. .00 51 .01 1SG2527
ATOM 2527 C SER 334 62, .108 29 .321 40, .588 1. .00 51 .01 1SG2528
ATOM 2528 O SER 334 61, .014 28 .759 40 .626 1, .00 51 .01 1SG2529
ATOM 2529 N LEU 335 62. .308 30, .484 39, .933 1. .00 53, .62 1SG2530
ATOM 2530 CA LEU 335 61. .281 31, .063 39, .118 1. .00 53 .62 1SG2531
ATOM 2531 CB LEU 335 61. .552 32, .543 38, .809 1. .00 53 .62 1SG2532
ATOM 2532 CG LEU 335 61. .561 33 .432 40 .066 1. .00 53 .62 1SG2533
ATOM 2533 CD2 LEU 335 60. .282 33, .241 40, .896 1. .00 53, .62 1SG2534
ATOM 2534 CD1 LEU 335 61. .831 34, .901 39, .714 1. .00 53 .62 1SG2535
ATOM 2535 C LEU 335 61. .165 30, .329 37, .810 1. .00 53 .62 1SG2536
ATOM 2536 O LEU 335 60. .094 29 .846 37, .450 1, .00 53 .62 1SG2537
ATOM 2537 N PHE 336 62 .289 30 .204 37 .070 1. .00 52 .84 1SG2538
ATOM 2538 CA PHE 336 62. .239 29, .568 35, .781 1. .00 52, .84 1SG2539
ATOM 2539 CB PHE 336 61, .451 30, .374 34, .737 1. .00 52 .84 1SG2540
ATOM 2540 CG PHE 336 62, .142 31, .684 34, .582 1, .00 52 .84 1SG2541
ATOM 2541 CD1 PHE 336 61, .898 32 .708 35, .463 1. .00 52 .84 1SG2542
ATOM 2542 CD2 PHE 336 63. .035 31, .892 33. .562 1. .00 52, .84 1SG2543
ATOM 2543 CE1 PHE 336 62 , .526 33, .923 35, .335 1. .00 52, .84 1SG2544
ATOM 2544 CE2 PHE 336 63. .668 33, .104 33, .427 1. .00 52, .84 1SG2545
ATOM 2545 CZ PHE 336 63. .417 34. .124 34, .311 1. .00 52 .84 1SG2546
ATOM 2546 C PHE 336 63. .632 29. .390 35, .255 1. .00 52 .84 1SG2547
ATOM 2547 O PHE 336 64. .593 29. .948 35. .783 1. ,00 52. .84 1SG2548
ATOM 2548 N SER 337 63. .772 28. .588 34. .177 1. ,00 46. .79 1SG2549
ATOM 2549 CA SER 337 65. .070 28. .376 33. .602 1. ,00 46, .79 1SG2550
ATOM 2550 CB SER 337 65, .523 26. .906 33. .630 1. .00 46, .79 1SG2551
ATOM 2551 OG SER 337 65. .664 26. .464 34. .972 1. .00 46. .79 1SG2552
ATOM 2552 C SER 337 65. .018 28, .805 32. .168 1. .00 46. .79 1SG2553
ATOM 2553 O SER 337 64, .069 28. .507 31. .445 1. ,00 46. .79 1SG2554
ATOM 2554 N LEU 338 66, .061 29. .532 31. .721 1. ,00 40. .45 1SG2555
ATOM 2555 CA LEU 338 66, .107 30. .028 30. .375 1. .00 40, .45 1SG2556
ATOM 2556 CB LEU 338 66. .270 31. .554 30. .312 1. .00 40. .45 1SG2557
ATOM 2557 CG LEU 338 66. .328 32. .117 28. .882 1. .00 40. .45 1SG2558
ATOM 2558 CD2 LEU 338 66. .860 33, .556 28. .881 1. .00 40. .45 1SG2559
ATOM 2559 CD1 LEU 338 64, .979 31, .965 28. .160 1. .00 40, .45 1SG2560
ATOM 2560 C LEU 338 67. .303 29. .448 29. .691 1. 00 40. ,45 1SG2561
ATOM 2561 O LEU 338 68. .353 29. .264 30. .304 1. 00 40. ,45 1SG2562
ATOM 2562 N ASP 339 67. .163 29. .132 28. ,388 1. 00 34. ,42 1SG2563 ATOM 2563 CA ASP 339 68..286 28..631 27..651 1.00 34..42 1SG2564
ATOM 2564 CB ASP 339 68. .016 27. .308 26. .914 1. .00 34. .42 1SG2565
ATOM 2565 CG ASP 339 69. .331 26. .802 26. .336 1. .00 34. .42 1SG2566
ATOM 2566 OD1 ASP 339 70, .348 27, .540 26. .432 1. ,00 34. .42 1SG2567
ATOM 2567 OD2 ASP 339 69. .336 25. .664 25. .795 1. .00 34. .42 1SG2568
ATOM 2568 C ASP 339 68. .626 29. .669 26. .632 1. 00 34. .42 1SG2569
ATOM 2569 O ASP 339 67. .807 30. .012 25. .781 1. ,00 34. .42 1SG2570
ATOM 2570 N VAL 340 69, .852 30, .216 26. .706 1. ,00 29. .59 1SG2571
ATOM 2571 CA VAL 340 70. .224 31, .235 25. .772 1. ,00 29, .59 1SG2572
ATOM 2572 CB VAL 340 70. .583 32, .538 26. .424 1. .00 29, .59 1SG2573
ATOM 2573 CGI VAL 340 71. .059 33, .515 25. ,335 1. .00 29. .59 1SG2574
ATOM 2574 CG2 VAL 340 69, .367 33 .037 27. .224 1. .00 29 .59 1SG2575
ATOM 2575 C VAL 340 71, .427 30, .778 25. .013 1. .00 29. .59 1SG2576
ATOM 2576 0 VAL 340 72. .297 30. .094 25. .550 1. .00 29. .59 1SG2577
ATOM 2577 N VAL 341 71. .480 31, .141 23. .715 1. ,00 29. .57 1SG2578
ATOM 2578 CA VAL 341 72. .595 30, .828 22. ,868 1. ,00 29. .57 1SG2579
ATOM 2579 CB VAL 341 72, .375 29 .620 22. .006 1. .00 29 .57 1SG2580
ATOM 2580 CGI VAL 341 73. .578 29 .468 21. .059 1. .00 29 .57 1SG2581
ATOM 2581 CG2 VAL 341 72. .142 28, .403 22. .918 1. .00 29 .57 1SG2582
ATOM 2582 C VAL 341 72. .745 32, .000 21. .952 1. .00 29 .57 1SG2583
ATOM 2583 O VAL 341 71. .769 32, .700 21. .687 1. .00 29, .57 1SG2584
ATOM 2584 N VAL 342 73. .974 32 .267 21. .460 1, .00 31 .25 1SG2585
ATOM 2585 CA VAL 342 74. .170 33 .402 20. .597 1. .00 31 .25 1SG2586
ATOM 2586 CB VAL 342 74, .405 34 .679 21. .388 1. .00 31 .25 1SG2587
ATOM 2587 CGI VAL 342 74, .542 35, .892 20. .450 1. .00 31 .25 1SG2588
ATOM 2588 CG2 VAL 342 73, .287 34, .855 22. .428 1. .00 31 .25 1SG2589
ATOM 2589 C VAL 342 75 .413 33 .099 19. .796 1, .00 31 .25 1SG2590
ATOM 2590 O VAL 342 76, .027 32 .053 19, .992 1, .00 31 .25 1SG2591
ATOM 2591 N ASN 343 75, .788 33 .983 18, .842 1. .00 34 .02 1SG2592
ATOM 2592 CA ASN 343 76. .995 33 .869 18, .069 1. .00 34 .02 1SG2593
ATOM 2593 CB ASN 343 76. .760 33 .865 16, .549 1. .00 34 .02 1SG2594
ATOM 2594 CG ASN 343 76. .077 32 .556 16, .180 1, .00 34 .02 1SG2595
ATOM 2595 OD1 ASN 343 76, .382 31 .503 16, .739 1, .00 34 .02 1SG2596
ATOM 2596 ND2 ASN 343 75. .124 32 .620 15, .212 1. .00 34 .02 1SG2597
ATOM 2597 C ASN 343 77, .800 35 .096 18, .394 1. .00 34 .02 1SG2598
ATOM 2598 O ASN 343 77. .238 36 .169 18, .608 1. .00 34 .02 1SG2599
ATOM 2599 N LEU 344 79 .144 34 .965 18 .460 1. .00 38 .21 1SG2600
ATOM 2600 CA LEU 344 79. .979 36 .065 18, .864 1. .00 38 .21 1SG2601
ATOM 2601 CB LEU 344 80. .674 35 .820 20, .216 1, .00 38 .21 1SG2602
ATOM 2602 CG LEU 344 79. .762 35 .387 21, .380 1. .00 38 .21 1SG2603
ATOM 2603 CD2 LEU 344 79. .113 34 .018 21. .121 1. .00 38 .21 1SG2604
ATOM 2604 CD1 LEU 344 78. .744 36 .471 21, .733 1, .00 38 .21 1SG2605
ATOM 2605 C LEU 344 81. .136 36 .169 17, .919 1, .00 38 .21 1SG2606
ATOM 2606 O LEU 344 81. .432 35 .244 17, .167 1. .00 38 .21 1SG2607
ATOM 2607 N ARG 345 81, .837 37 .321 17, .963 1. .00 41, .25 1SG2608
ATOM 2608 CA ARG 345 83. .020 37 .507 17, .175 1. .00 41, .25 1SG2609
ATOM 2609 CB ARG 345 83. .069 38 .872 16 .467 1, .00 41 .25 1SG2610
ATOM 2610 CG ARG 345 81, .974 39 .055 15, .414 1. .00 41 .25 1SG2611
ATOM 2611 CD ARG 345 81, .938 40 .458 14, .803 1. .00 41 .25 1SG2612
ATOM 2612 NE ARG 345 83, .207 40 .654 14, .047 1. .00 41 .25 1SG2613
ATOM 2613 CZ ARG 345 83. .435 41 .831 13. .393 1. .00 41, .25 1SG2614
ATOM 2614 NH1 ARG 345 82. .500 42 .825 13. .429 1. .00 41 .25 1SG2615
ATOM 2615 NH2 ARG 345 84 , .600 42 .015 12, .705 1. .00 41 .25 1SG2616
ATOM 2616 C ARG 345 84 , .160 37 .472 18, .144 1. .00 41, .25 1SG2617
ATOM 2617 O ARG 345 84. .098 38 .091 19. .206 1. .00 41, .25 1SG2618
ATOM 2618 N LEU 346 85. .229 36, .720 17. .812 1. .00 42, .25 1SG2619
ATOM 2619 CA LEU 346 86. .349 36 .635 18. .705 1. .00 42 .25 1SG2620 ATOM 2620 CB LEU 346 86..758 35..190 19..041 1..00 42..25 1SG2621
ATOM 2621 CG LEU 346 85, .666 34, .405 19 .792 1, .00 42, .25 1SG2622
ATOM 2622 CD2 LEU 346 86. .200 33. .054 20, .297 1. .00 42, .25 1SG2623
ATOM 2623 CD1 LEU 346 84. .400 34, .263 18 .934 1, .00 42, .25 1SG2624
ATOM 2624 C LEU 346 87. .515 37, .276 18 .026 1, .00 42, .25 1SG2625
ATOM 2625 O LEU 346 87, .927 36, .861 16, .944 1. .00 42. .25 1SG2626
ATOM 2626 N GLN 347 88. .082 38. .321 18 .654 1. .00 41, .37 1SG2627
ATOM 2627 CA GLN 347 89. .202 38. .998 18, .070 1. .00 41. .37 1SG2628
ATOM 2628 CB GLN 347 89, .166 40. .518 18 .306 1. .00 41, .37 1SG2629
ATOM 2629 CG GLN 347 90, .179 41. .290 17 .463 1, .00 41, .37 1SG2630
ATOM 2630 CD GLN 347 89, .664 41 .301 16 .031 1 .00 41 .37 1SG2631
ATOM 2631 OEl GLN 347 90. .440 41. .256 15 .078 1 .00 41, .37 1SG2632
ATOM 2632 NE2 GLN 347 88. .315 41. .364 15, .873 1, .00 41. .37 1SG2633
ATOM 2633 C GLN 347 90, .434 38, .458 18 .728 1, .00 41. .37 1SG2634
ATOM 2634 O GLN 347 90, .411 38, .124 19 .912 1 .00 41 .37 1SG2635
ATOM 2635 N LEU 348 91, .546 38, .337 17, .970 1, .00 37. .86 1SG2636
ATOM 2636 CA LEU 348 92. .745 37, .797 18 .550 1 .00 37 .86 1SG2637
ATOM 2637 CB LEU 348 93 .150 36 .442 17 .942 1 .00 37 .86 1SG2638
ATOM 2638 CG LEU 348 92. .095 35, .332 18 .116 1, .00 37 .86 1SG2639
ATOM 2639 CD2 LEU 348 90. .789 35. .677 17, .381 1. .00 37 .86 1SG2640
ATOM 2640 CD1 LEU 348 91. .879 34, .987 19, .598 1, .00 37 .86 1SG2641
ATOM 2641 C LEU 348 93. .886 38, .740 18, .296 1, .00 37 .86 1SG2642
ATOM 2642 O LEU 348 94. .055 39, .249 17 .188 1 .00 37 .86 1SG2643
ATOM 2643 N SER 349 94, .712 38. .982 19, .337 1 .00 34 .29 1SG2644
ATOM 2644 CA SER 349 95, .856 39. .847 19, .228 1 .00 34 .29 1SG2645
ATOM 2645 CB SER 349 95, .594 41. .278 19, .731 1, .00 34 .29 1SG2646
ATOM 2646 OG SER 349 94, .612 41. .908 18, .921 1 .00 34 .29 1SG2647
ATOM 2647 C SER 349 96. .928 39. .267 20 .099 1 .00 34 .29 1SG2648
ATOM 2648 O SER 349 96. .683 38, .324 20, .850 1, .00 34 .29 1SG2649
ATOM 2649 N VAL 350 98 .164 39, .802 20 .006 1 .00 32 .80 1SG2650
ATOM 2650 CA VAL 350 99 .218 39, .259 20 .815 1 .00 32 .80 1SG2651
ATOM 2651 CB VAL 350 100. .256 38. .526 20, .016 1, .00 32 .80 1SG2652
ATOM 2652 CGI VAL 350 101. .379 38. .078 20, .966 1. .00 32. .80 1SG2653
ATOM 2653 CG2 VAL 350 99, .572 37. .373 19, .263 1, .00 32 .80 1SG2654
ATOM 2654 C VAL 350 99 .927 40. .371 21, .520 1, .00 32 .80 1SG2655
ATOM 2655 O VAL 350 100 .177 41. .434 20 .953 1 .00 32 .80 1SG2656
ATOM 2656 N SER 351 100, .267 40. .135 22, .802 1, .00 33 .54 1SG2657
ATOM 2657 CA SER 351 101, .020 41, .075 23 .577 1, .00 33 .54 1SG2658
ATOM 2658 CB SER 351 100, .206 41. .755 24, .692 1, .00 33. .54 1SG2659
ATOM 2659 OG SER 351 99, .169 42. .545 24, .127 1, .00 33 .54 1SG2660
ATOM 2660 C SER 351 102. .077 40. .258 24, ,239 1, .00 33. .54 1SG2661
ATOM 2661 O SER 351 101. .788 39. .161 24, .719 1, .00 33, .54 1SG2662
ATOM 2662 N LYS 352 103. .328 40, ,766 24, .281 1. .00 36. .28 1SG2663
ATOM 2663 CA LYS 352 104 .379 39, .984 24 .865 1 .00 36 .28 1SG2664
ATOM 2664 CB LYS 352 104. ,148 39. ,659 26. .351 1, .00 36, .28 1SG2665
ATOM 2665 CG LYS 352 105. .365 39. ,035 27. .038 1. .00 36. .28 1SG2666
ATOM 2666 CD LYS 352 106, .542 40. .002 27. .181 1. .00 36. .28 1SG2667
ATOM 2667 CE LYS 352 106, .244 41. ,201 28. .085 1. .00 36. .28 1SG2668
ATOM 2668 NZ LYS 352 106, .238 40. .778 29 .503 1. .00 36. .28 1SG2669
ATOM 2669 C LYS 352 104 , .403 38. .712 24. .087 1. .00 36, .28 1SG2670
ATOM 2670 O LYS 352 104, .362 38. .730 22. .857 1, .00 36, .28 1SG2671
ATOM 2671 N VAL 353 104. .512 37. ,565 24. .780 1. .00 36. .52 1SG2672
ATOM 2672 CA VAL 353 104. .383 36. ,341 24. .049 1. .00 36. .52 1SG2673
ATOM 2673 CB VAL 353 105. .538 35. ,403 24. .246 1. .00 36. .52 1SG2674
ATOM 2674 CGI VAL 353 105. .262 34. .109 23. .460 1. .00 36. .52 1SG2675
ATOM 2675 CG2 VAL 353 106. .827 36. .124 23. .816 1. .00 36. .52 1SG2676
ATOM 2676 C VAL 353 103. .159 35. .678 24. .596 1. .00 36. .52 1SG2677 ATOM 2677 O VAL 353 103.238 34.,630 25.237 1.00 36.52 1SG2678
ATOM 2678 N LYS 354 101. 978 36. 273 24. 331 1. 00 34. 90 1SG2679
ATOM 2679 CA LYS 354 100. 761 35. 714 24. 843 1. 00 34. 90 1SG2680
ATOM 2680 CB LYS 354 100. 217 36. 449 26. 082 1. 00 34. 90 1SG2681
ATOM 2681 CG LYS 354 101. 111 36. .323 27. 319 1. 00 34. 90 1SG2682
ATOM 2682 CD LYS 354 100. ,744 37. .292 28. 445 1. 00 34. ,90 1SG2683
ATOM 2683 CE LYS 354 101. .096 38. .749 28. ,140 1. 00 34. 90 1SG2684
ATOM 2684 NZ LYS 354 100. ,704 39. .614 29. 275 1. 00 34. .90 1SG2685
ATOM 2685 C LYS 354 99. ,725 35. .837 23. .779 1. ,00 34, .90 1SG2686
ATOM 2686 O LYS 354 99. .832 36. .674 22. ,885 1. ,00 34. .90 1SG2687
ATOM 2687 N LEU 355 98. .692 34. ,976 23. ,849 1. 00 33. 11 1SG2688
ATOM 2688 CA LEU 355 97. .624 35. .030 22. 897 1. 00 33. .11 1SG2689
ATOM 2689 CB LEU 355 97. .222 33. .639 22. .371 1. ,00 33. .11 1SG2690
ATOM 2690 CG LEU 355 96. .079 33. .649 21. .338 1. ,00 33. .11 1SG2691
ATOM 2691 CD2 LEU 355 95. .533 32. .234 21. .088 1. .00 33. .11 1SG2692
ATOM 2692 CD1 LEU 355 96. .511 34, .356 20. .043 1. ,00 33. .11 1SG2693
ATOM 2693 C LEU 355 96. .459 35. .592 23. .647 1. .00 33. .11 1SG2694
ATOM 2694 O LEU 355 95. .973 34. .984 24. .600 1. .00 33. .11 1SG2695
ATOM 2695 N GLN 356 95, .989 36, .785 23. .240 1. .00 32. .29 1SG2696
ATOM 2696 CA GLN 356 94. ,898 37, .417 23. .922 1. .00 32. .29 1SG2697
ATOM 2697 CB GLN 356 95. .226 38. .845 24. .396 1. .00 32 , .29 1SG2698
ATOM 2698 CG GLN 356 94. .074 39, .535 25. .127 1. .00 32. .29 1SG2699
ATOM 2699 CD GLN 356 94. .545 40. .925 25. .529 1. .00 32. .29 1SG2700
ATOM 2700 OEl GLN 356 95. .676 41 .315 25. .245 1. .00 32. .29 1SG2701
ATOM 2701 NE2 GLN 356 93. .654 41. .699 26. .205 1. .00 32 .29 1SG2702
ATOM 2702 C GLN 356 93. .783 37 .538 22. .945 1. .00 32 .29 1SG2703
ATOM 2703 O GLN 356 93 .999 37 .531 21. .734 1, .00 32 .29 1SG2704
ATOM 2704 N GLY 357 92, .541 37 .637 23 .449 1 .00 33 .31 1SG2705
ATOM 2705 CA GLY 357 91, .450 37. .769 22 , .539 1. .00 33 .31 1SG2706
ATOM 2706 C GLY 357 90. .317 38 .362 23 .286 1, .00 33 .31 1SG2707
ATOM 2707 O GLY 357 90. .326 38 .413 24, .514 1. .00 33 .31 1SG2708
ATOM 2708 N THR 358 89 .307 38, .856 22 .554 1 .00 38 .48 1SG2709
ATOM 2709 CA THR 358 88 .194 39 .395 23 .257 1, .00 38 .48 1SG2710
ATOM 2710 CB THR 358 88 .177 40 .896 23 .293 1 .00 38 .48 1SG2711
ATOM 2711 OGl THR 358 88 .071 41 .418 21 .977 1, .00 38 .48 1SG2712
ATOM 2712 CG2 THR 358 89 .474 41 .387 23 .957 1 .00 38 .48 1SG2713
ATOM 2713 C THR 358 86 .964 38 .962 22 .550 1 .00 38 .48 1SG2714
ATOM 2714 O THR 358 86 .933 38 .898 21 .321 1 .00 38 .48 1SG2715
ATOM 2715 N THR 359 85 .915 38 .629 23 .323 1, .00 43, .84 1SG2716
ATOM 2716 CA THR 359 84 .676 38 .403 22 .665 1 .00 43 .84 1SG2717
ATOM 2717 CB THR 359 8 .650 37 .684 23 .504 1, .00 43 .84 1SG2718
ATOM 2718 OGl THR 359 83 .380 38 .382 24 .711 1 .00 43 .84 1SG2719
ATOM 2719 CG2 THR 359 84 .188 36 .278 23 .820 1 .00 43 .84 1SG2720
ATOM 2720 C THR 359 84 .270 39 .805 22 .406 1 .00 43 .84 1SG2721
ATOM 2721 O THR 359 83 .602 40 .455 23 .211 1 .00 43 .84 1SG2722
ATOM 2722 N SER 360 84 .734 40 .312 21 .252 1 .00 45 .42 1SG2723
ATOM 2723 CA SER 360 84 .544 41 .681 20 .928 1 .00 45 .42 1SG2724
ATOM 2724 CB SER 360 85 .059 42 .046 19 .526 1 .00 45 .42 1SG2725
ATOM 2725 OG SER 360 84 .832 43 .423 19 .266 1 .00 45 .42 1SG2726
ATOM 2726 C SER 360 83 .086 41 .884 20 .935 1 .00 45 .42 1SG2727
ATOM 2727 O SER 360 82 .593 42 .906 21 .411 1 .00 45 .42 1SG2728
ATOM 2728 N VAL 361 82 .340 40 .887 20 .434 1 .00 46 .61 1SG2729
ATOM 2729 CA VAL 361 80 .954 41 .181 20 .426 1 .00 46 .61 1SG2730
ATOM 2730 CB VAL 361 80 .495 41 .895 19 .184 1 .00 46 .61 1SG2731
ATOM 2731 CGI VAL 361 81 .190 43 .263 19 .087 1 .00 46 .61 1SG2732
ATOM 2732 CG2 VAL 361 80 .758 40 .977 17 .979 1 .00 46 .61 1SG2733
ATOM 2733 C VAL 361 80 .137 39 .949 20 .488 1 .00 46 .61 1SG2734 ATOM 2734 O VAL 361 80..581 38..841 20..191 1.,00 46.,61 1SG2735
ATOM 2735 N LEU 362 78. .877 40. .173 20. .890 1. .00 42. .03 1SG2736
ATOM 2736 CA LEU 362 77. .867 39. ,176 20. .978 1. .00 42. .03 1SG2737
ATOM 2737 CB LEU 362 77. .421 39. .008 22. .451 1. ,00 42. .03 1SG2738
ATOM 2738 CG LEU 362 76. .396 37. .906 22, .773 1. ,00 42. .03 1SG2739
ATOM 2739 CD2 LEU 362 75. .028 38. .225 22, .178 1. .00 42. .03 1SG2740
ATOM 2740 CD1 LEU 362 76, .287 37, .682 24, .288 1. .00 42. .03 1SG2741
ATOM 2741 C LEU 362 76, .775 39. .702 20. .094 1. .00 42. .03 1SG2742
ATOM 2742 O LEU 362 76, .606 40. .914 19, .974 1. .00 42. .03 1SG2743
ATOM 2743 N GLY 363 76, .035 38. .811 19, .404 1. .00 35. .71 1SG2744
ATOM 2744 CA GLY 363 75, .035 39. .252 18, .469 1. .00 35. .71 1SG2745
ATOM 2745 C GLY 363 73, .710 39. .277 19, .155 1. .00 35. .71 1SG2746
ATOM 2746 O GLY 363 73, .605 39. .628 20, .326 1. .00 35. .71 1SG2747
ATOM 2747 N ASP 364 72, .634 38. .940 18, .420 1. .00 33. .18 1SG2748
ATOM 2748 CA ASP 364 71, .352 38. .913 19, .056 1. .00 33, .18 1SG2749
ATOM 2749 CB ASP 364 70, .174 38. .794 18, .075 1. .00 33, .18 1SG2750
ATOM 2750 CG ASP 364 70, .075 40. .098 17, .297 1. .00 33, .18 1SG2751
ATOM 2751 OD1 ASP 364 70, .802 41. .061 17, .662 1. .00 33, .18 1SG2752
ATOM 2752 OD2 ASP 364 69. .276 40. .148 16, .324 1. .00 33. .18 1SG2753
ATOM 2753 C ASP 364 71. .348 37. .697 19, .921 1. .00 33, .18 1SG2754
ATOM 2754 O ASP 364 72. .054 36. .730 19, .643 1, .00 33, .18 1SG2755
ATOM 2755 N VAL 365 70. .557 37. .715 21, .010 1. .00 32, .78 1SG2756
ATOM 2756 CA VAL 365 70, .537 36. .572 21, .872 1, .00 32, .78 1SG2757
ATOM 2757 CB VAL 365 70, .622 36. .921 23, .329 1. .00 32, .78 1SG2758
ATOM 2758 CGI VAL 365 71, .977 37. .602 23, .590 1. .00 32, .78 1SG2759
ATOM 2759 CG2 VAL 365 69, .407 37. .789 23 .696 1, .00 32 .78 1SG2760
ATOM 2760 C VAL 365 69, .232 35. .877 21, .661 1. .00 32 .78 1SG2761
ATOM 2761 O VAL 365 68, .197 36. .522 21, .507 1. .00 32, .78 1SG2762
ATOM 2762 N GLN 366 69 .249 34, .528 21 .623 1. .00 34 .74 1SG2763
ATOM 2763 CA GLN 366 68, .005 33. .836 21 .463 1. .00 34 .74 1SG2764
ATOM 2764 CB GLN 366 67, .957 32. .799 20 .322 1. .00 34 .74 1SG2765
ATOM 2765 CG GLN 366 68, .918 31. .619 20, .466 1, .00 34 .74 1SG2766
ATOM 2766 CD GLN 366 70, .150 31. .915 19 .623 1. .00 34 .74 1SG2767
ATOM 2767 OEl GLN 366 71, .087 31. .120 19, .571 1. .00 34, .74 1SG2768
ATOM 2768 NE2 GLN 366 70, .151 33. .093 18 .943 1, .00 34. .74 1SG2769
ATOM 2769 C GLN 366 67, .709 33. .136 22 .745 1. .00 34. .74 1SG2770
ATOM 2770 O GLN 366 68, .572 32. .491 23, .339 1, .00 34, .74 1SG2771
ATOM 2771 N LEU 367 66, .456 33. .268 23 .214 1. .00 36. .38 1SG2772
ATOM 2772 CA LEU 367 66, .096 32, .677 24, .463 1. .00 36. .38 1SG2773
ATOM 2773 CB LEU 367 65, .496 33, .691 25, .453 1. .00 36. .38 1SG2774
ATOM 2774 CG LEU 367 66, .495 34. .801 25, .845 1. .00 36. .38 1SG2775
ATOM 2775 CD2 LEU 367 65, .974 35. .650 27, .009 1. .00 36. .38 1SG2776
ATOM 2776 CD1 LEU 367 66, .885 35. .667 24, .639 1. .00 36, .38 1SG2777
ATOM 2777 C LEU 367 65, .090 31. .609 24, .202 1. .00 36, .38 1SG2778
ATOM 2778 O LEU 367 64, .384 31. .633 23, .196 1. .00 36, .38 1SG2779
ATOM 2779 N THR 368 65, .053 30. .600 25, .092 1. .00 36, .21 1SG2780
ATOM 2780 CA THR 368 64, .074 29. .559 25, .003 1. .00 36. .21 1SG2781
ATOM 2781 CB THR 368 64, .565 28. .301 24, .350 1. .00 36. .21 1SG2782
ATOM 2782 OGl THR 368 63, .479 27. .419 24, .107 1. .00 36. .21 1SG2783
ATOM 2783 CG2 THR 368 65, .591 27. .632 25, .275 1. .00 36. .21 1SG2784
ATOM 2784 C THR 368 63, .714 29. .233 26, .415 1. .00 36. .21 1SG2785
ATOM 2785 O THR 368 64, .537 29. .390 27, .316 1. .00 36. .21 1SG2786
ATOM 2786 N VAL 369 62, .469 28. .781 26, .660 1. .00 35. .84 1SG2787
ATOM 2787 CA VAL 369 62, .115 28. .490 28, .019 1. .00 35. .84 1SG2788
ATOM 2788 CB VAL 369 60, .750 28. .976 28, .410 1. .00 35. .84 1SG2789
ATOM 2789 CGI VAL 369 60, .424 28. .436 29, .813 1. .00 35. .84 1SG2790
ATOM 2790 CG2 VAL 369 60, .741 30. .511 28, .334 1. .00 35. .84 1SG2791 ATOM 2791 C VAL 369 62,.135 27,.009 28,.219 1,.00 35..84 1SG2792
ATOM 2792 O VAL 369 61, .399 26 .273 27, .563 1, .00 35, .84 1SG2793
ATOM 2793 N ALA 370 63 .045 26 .535 29, .096 1, .00 37, .32 1SG2794
ATOM 2794 CA ALA 370 63. .135 25 .141 29, .423 1, .00 37, .32 1SG2795
ATOM 2795 CB ALA 370 64. .410 24 .800 30 .211 1, .00 37, .32 1SG2796
ATOM 2796 C ALA 370 61 .966 24 .724 30, .262 1 .00 37, .32 1SG2797
ATOM 2797 O ALA 370 61 .308 23 .727 29 .972 1, .00 37, .32 1SG2798
ATOM 2798 N SER 371 61 .674 25 .495 31 .332 1 .00 42, .85 1SG2799
ATOM 2799 CA SER 371 60 .590 25 .156 32 .211 1, .00 42, .85 1SG2800
ATOM 2800 CB SER 371 60 .884 23 .941 33 .106 1 .00 42 .85 1SG2801
ATOM 2801 OG SER 371 59 .768 23 .666 33 .940 1 .00 42 .85 1SG2802
ATOM 2802 C SER 371 60 .346 26 .321 33 .113 1 .00 42, .85 1SG2803
ATOM 2803 O SER 371 61, .246 27, .121 33, .360 1, .00 42, .85 1SG2804
ATOM 2804 N SER 372 59, .105 26, .446 33, .632 1, .00 47, .76 1SG2805
ATOM 2805 CA SER 372 58, .806 27, .541 34 , .505 1, .00 47, .76 1SG2806
ATOM 2806 CB SER 372 57, .903 28, .627 33, .895 1, .00 47, .76 1SG2807
ATOM 2807 OG SER 372 58, .629 29, .466 33. .016 1, .00 47, .76 1SG2808
ATOM 2808 C SER 372 58, .021 27, .042 35. .663 1, .00 47, .76 1SG2809
ATOM 2809 O SER 372 57, .106 26, .232 35, .523 1, .00 47, .76 1SG2810
ATOM 2810 N ASN 373 58. .394 27, .523 36, .856 1, .00 50, .98 1SG2811
ATOM 2811 CA ASN 373 57, .667 27. .228 38, .044 1. .00 50, .98 1SG2812
ATOM 2812 CB ASN 373 58, .469 27. .600 39, .298 1, .00 50, .98 1SG2813
ATOM 2813 CG ASN 373 58. .023 26, .647 40, .383 1, .00 50, .98 1SG2814
ATOM 2814 OD1 ASN 373 57, .274 25, .718 40. .088 1, .00 50, .98 1SG2815
ATOM 2815 ND2 ASN 373 58, .495 26, .858 41. .640 1. .00 50, .98 1SG2816
ATOM 2816 C ASN 373 56. .437 28, .089 37. .989 1, .00 50, .98 1SG2817
ATOM 2817 O ASN 373 55, .360 27, .717 38. .452 1, .00 50, .98 1SG2818
ATOM 2818 N VAL 374 56, .626 29, .293 37, .410 1. .00 52, .24 1SG2819
ATOM 2819 CA VAL 374 55, .715 30, .395 37. .248 1, .00 52, .24 1SG2820
ATOM 2820 CB VAL 374 56, .414 31, .608 36. .707 1, .00 52, .24 1SG2821
ATOM 2821 CGI VAL 374 57, .516 32, .019 37. .698 1. .00 52, .24 1SG2822
ATOM 2822 CG2 VAL 374 56, .933 31, .285 35. .296 1, .00 52, .24 1SG2823
ATOM 2823 C VAL 374 54, .603 30, .080 36. .298 1. .00 52, .24 1SG2824
ATOM 2824 O VAL 374 53, .550 30, .709 36, .363 1, .00 52, .24 1SG2825
ATOM 2825 N GLY 375 54, .807 29, .152 35, .347 1, .00 48, .06 1SG2826
ATOM 2826 CA GLY 375 53, .768 28, .884 34, .393 1. .00 48, .06 1SG2827
ATOM 2827 C GLY 375 54, .243 29, .426 33, .084 1, .00 48, .06 1SG2828
ATOM 2828 O GLY 375 55, .242 30. .141 33 , .030 1. .00 48, .06 1SG2829
ATOM 2829 N PHE 376 53, .533 29, .088 31. .988 1, .00 45, .09 1SG2830
ATOM 2830 CA PHE 376 53, .950 29, .495 30. .676 1. .00 45, .09 1SG2831
ATOM 2831 CB PHE 376 53 , .083 28, .915 29. .545 1. .00 45, .09 1SG2832
ATOM 2832 CG PHE 376 53, .332 27, .446 29, .499 1. .00 45, .09 1SG2833
ATOM 2833 CD1 PHE 376 54. .418 26, .945 28. .818 1. .00 45, .09 1SG2834
ATOM 2834 CD2 PHE 376 52. .483 26, .571 30. .135 1. .00 45, .09 1SG2835
ATOM 2835 CE1 PHE 376 54. .653 25. .592 28. .773 1. .00 45. .09 1SG2836
ATOM 2836 CE2 PHE 376 52. .713 25. .216 30. .092 1. .00 45. .09 1SG2837
ATOM 2837 CZ PHE 376 53. .800 24. .724 29. .411 1. .00 45. .09 1SG2838
ATOM 2838 C PHE 376 53. .914 30. .982 30. .575 1. .00 45. .09 1SG2839
ATOM 2839 O PHE 376 52. .984 31, .636 31. .049 1. .00 45. .09 1SG2840
ATOM 2840 N ILE 377 54. .964 31. .542 29. .949 1. .00 41. .21 1SG2841
ATOM 2841 CA ILE 377 55. .151 32. .956 29. .798 1. .00 41. .21 1SG2842
ATOM 2842 CB ILE 377 56. .171 33. .470 30. .763 1. .00 41. .21 1SG2843
ATOM 2843 CG2 ILE 377 57. .455 32. .655 30. .553 1. ,00 41. .21 1SG2844
ATOM 2844 CGI ILE 377 56. .381 34. .980 30. .611 1. ,00 41. .21 1SG2845
ATOM 2845 CD1 ILE 377 57. .421 35. .522 31. .591 1. .00 41. .21 1SG2846
ATOM 2846 C ILE 377 55. .739 33. .206 28. .451 1. .00 41. .21 1SG2847
ATOM 2847 O ILE 377 56. ,333 32. .314 27. ,841 1. .00 41. .21 1SG2848 ATOM 2848 N ASP 378 55..591 34..446 27..948 1..00 36..95 1SG2849
ATOM 2849 CA ASP 378 56. .222 34. .763 26. .707 1. .00 36. .95 1SG2850
ATOM 2850 CB ASP 378 55, .774 36. .111 26, .111 1. .00 36. .95 1SG2851
ATOM 2851 CG ASP 378 54. .331 35. .963 25. .649 1. ,00 36. .95 1SG2852
ATOM 2852 OD1 ASP 378 53. .829 34. .808 25. .634 1. .00 36. .95 1SG2853
ATOM 2853 OD2 ASP 378 53. .711 37. .005 25. .309 1. ,00 36. .95 1SG2854
ATOM 2854 C ASP 378 57, .683 34. .858 27, .014 1. .00 36, .95 1SG2855
ATOM 2855 O ASP 378 58, .116 35, .664 27, .835 1. .00 36, .95 1SG2856
ATOM 2856 N THR 379 58. .482 34. ,019 26. .338 1. ,00 36. .83 1SG2857
ATOM 2857 CA THR 379 59. .900 33. .924 26. .537 1. .00 36. .83 1SG2858
ATOM 2858 CB THR 379 60. .527 32. .873 25. .669 1. .00 36, .83 1SG2859
ATOM 2859 OGl THR 379 59. .925 31. .610 25. .910 1. .00 36, .83 1SG2860
ATOM 2860 CG2 THR 379 62. .031 32. .813 25. .981 1. .00 36, .83 1SG2861
ATOM 2861 C THR 379 60. .518 35. .227 26. .146 1. .00 36, .83 1ΞG2862
ATOM 2862 O THR 379 61. .578 35. .596 26. .645 1. .00 36, .83 1SG2863
ATOM 2863 N ASP 380 59, .871 35, .935 25. .206 1. .00 37, .32 1SG2864
ATOM 2864 CA ASP 380 60. .345 37. .158 24. .621 1. .00 37 .32 1SG2865
ATOM 2865 CB ASP 380 59. .435 37. .648 23, .484 1. .00 37, .32 1SG2866
ATOM 2866 CG ASP 380 59 .557 36. .657 22, .336 1. .00 37 .32 1SG2867
ATOM 2867 OD1 ASP 380 60 .468 35 .790 22 .397 1. .00 37 .32 1SG2868
ATOM 2868 OD2 ASP 380 58, .737 36. ,752 21, .383 1. .00 37 .32 1SG2869
ATOM 2869 C ASP 380 60, .441 38 , ,271 25. .625 1. .00 37, .32 1SG2870
ATOM 2870 O ASP 380 61, .240 39, .189 25. .450 1. .00 37, .32 1SG2871
ATOM 2871 N GLN 381 59 .620 38 .246 26. .688 1. .00 39 .73 1SG2872
ATOM 2872 CA GLN 381 59, .557 39 .338 27 .622 1. .00 39 .73 1SG2873
ATOM 2873 CB GLN 381 58, .471 39. .107 28. .685 1. .00 39, .73 1SG2874
ATOM 2874 CG GLN 381 58, .094 40, .360 29. .471 1. .00 39, .73 1SG2875
ATOM 2875 CD GLN 381 56, .789 40. .055 30. .189 1. .00 39 .73 1SG2876
ATOM 2876 OEl GLN 381 56 .534 38 .916 30 .577 1, .00 39 .73 1SG2877
ATOM 2877 NE2 GLN 381 55, .933 41, .097 30. .363 1, .00 39 .73 1SG2878
ATOM 2878 C GLN 381 60 .885 39 .571 28 .297 1, .00 39 .73 1SG2879
ATOM 2879 O GLN 381 61, .233 40, .712 28. .599 1. .00 39 .73 1SG2880
ATOM 2880 N VAL 382 61 .643 38, .493 28 .572 1, .00 42 .59 1SG2881
ATOM 2881 CA VAL 382 62, .926 38. .500 29, .233 1. .00 42 .59 1SG2882
ATOM 2882 CB VAL 382 63 .351 37. .137 29 .706 1, .00 42 .59 1SG2883
ATOM 2883 CGI VAL 382 63 .501 36 .217 28 .493 1. .00 42 .59 1SG2884
ATOM 2884 CG2 VAL 382 6 .627 37 .278 30 .553 1, .00 42 .59 1SG2885
ATOM 2885 C VAL 382 64, .012 39. .086 28, .373 1. .00 42, .59 1SG2886
ATOM 2886 O VAL 382 65, .096 39. .389 28, .867 1. .00 42, .59 1SG2887
ATOM 2887 N ARG 383 63, .779 39, .228 27 .057 1. .00 44, .93 1SG2888
ATOM 2888 CA ARG 383 64 .814 39, .644 26 .148 1. .00 44 .93 1SG2889
ATOM 2889 CB ARG 383 64, .294 39. .845 24 .715 1, .00 44 .93 1SG2890
ATOM 2890 CG ARG 383 65. .377 40. .285 23, .727 1. .00 44, .93 1SG2891
ATOM 2891 CD ARG 383 64, .859 40. .485 22, .301 1. .00 44, .93 1SG2892
ATOM 2892 NE ARG 383 66, .011 40. .920 21 .463 1. .00 44, .93 1SG2893
ATOM 2893 CZ ARG 383 66, .838 39. .992 20 .898 1, .00 44 .93 1SG2894
ATOM 2894 NH1 ARG 383 66, .611 38. .662 21, .102 1. .00 44, .93 1SG2895
ATOM 2895 NH2 ARG 383 67, .890 40, .396 20 .128 1, .00 44, .93 1SG2896
ATOM 2896 C ARG 383 65, .455 40, .935 26, .575 1. .00 44. .93 1SG2897
ATOM 2897 O ARG 383 66, .678 41, .049 26 .529 1. .00 44, .93 1SG2898
ATOM 2898 N THR 384 64. .674 41. .942 26, .997 1. .00 45. .35 1SG2899
ATOM 2899 CA THR 384 65. .261 43. .208 27, .354 1. .00 45. .35 1SG2900
ATOM 2900 CB THR 384 64, .235 44. .229 27 .752 1, .00 45. .35 1SG2901
ATOM 2901 OGl THR 384 63, .537 43. .797 28 .911 1, .00 45 .35 1SG2902
ATOM 2902 CG2 THR 384 63. ,254 44. ,420 26, .583 1. .00 45. .35 1SG2903
ATOM 2903 C THR 384 66. .188 43. ,028 28, .517 1. .00 45. .35 1SG2904
ATOM 2904 O THR 384 67. .288 43. .579 28, .536 1. .00 45, .35 1SG2905 ATOM 2905 N LEU 385 65..758 42,.255 29,.531 1..00 45,.49 1SG2906
ATOM 2906 CA LEU 385 66. .547 42 .050 30 .712 1, .00 45 .49 1SG2907
ATOM 2907 CB LEU 385 65. .768 41. .231 31. .769 1. .00 45, .49 1SG2908
ATOM 2908 CG LEU 385 66. .402 41, .087 33. .173 1. .00 45. .49 1SG2909
ATOM 2909 CD2 LEU 385 67, .828 40, .519 33 .144 1, .00 45, .49 1SG2910
ATOM 2910 CD1 LEU 385 65 .490 40 .254 34 .086 1 .00 45 .49 1SG2911
ATOM 2911 C LEU 385 67. .779 41, .302 30 .315 1, .00 45 .49 1SG2912
ATOM 2912 O LEU 385 68, .882 41, .603 30. .769 1, .00 45, .49 1SG2913
ATOM 2913 N MET 386 67, .608 40 .302 29 .439 1. .00 46 .23 1SG2914
ATOM 2914 CA MET 386 68 .677 39 .448 29 .020 1 .00 46 .23 1SG2915
ATOM 2915 CB MET 386 68, .177 38, .391 28 .020 1, .00 46 .23 1SG2916
ATOM 2916 CG MET 386 68, .971 37, .086 27 .990 1. .00 46, .23 1SG2917
ATOM 2917 SD MET 386 70, .767 37 .267 27 .837 1. .00 46 .23 1SG2918
ATOM 2918 CE MET 386 71, .036 37. .397 29, .627 1. .00 46, .23 1SG2919
ATOM 2919 C MET 386 69, .683 40 .291 28 .313 1. .00 46 .23 1SG2920
ATOM 2920 O MET 386 70, .885 40, .081 28, .457 1, .00 46. .23 1SG2921
ATOM 2921 N GLY 387 69, .205 41 .269 27 .521 1. .00 45 .40 1SG2922
ATOM 2922 CA GLY 387 70, .059 42, .101 26, .727 1. ,00 45, .40 1SG2923
ATOM 2923 C GLY 387 70, .967 42 .923 27 .581 1, .00 45 .40 1SG2924
ATOM 2924 O GLY 387 72, .121 43, .129 27, .216 1, .00 45 .40 1SG2925
ATOM 2925 N THR 388 70, .462 43 .493 28 .691 1, .00 45 .91 1SG2926
ATOM 2926 CA THR 388 71, .303 44. .307 29, .522 1, .00 45, .91 1SG2927
ATOM 2927 CB THR 388 70, .518 45, .176 30 .467 1, .00 45 .91 1SG2928
ATOM 2928 OGl THR 388 71, .394 46, .030 31, .187 1 .00 45 .91 1SG2929
ATOM 2929 CG2 THR 388 69, .705 44, .296 31 .432 1, .00 45 .91 1SG2930
ATOM 2930 C THR 388 72, .276 43, .490 30, .323 1, .00 45, .91 1SG2931
ATOM 2931 O THR 388 73, .474 43, .767 30 .338 1, .00 45, .91 1SG2932
ATOM 2932 N VAL 389 71. .778 42, .434 30 .994 1 .00 46 .95 1SG2933
ATOM 2933 CA VAL 389 72, .568 41, .665 31 .907 1, .00 46, .95 1SG2934
ATOM 2934 CB VAL 389 71. .767 40, .598 32, .593 1, .00 46 , .95 1SG2935
ATOM 2935 CGI VAL 389 70. .665 41. .279 33, .419 1, .00 46, .95 1SG2936
ATOM 2936 CG2 VAL 389 71. .223 39 .633 31 .532 1 .00 46 .95 1SG2937
ATOM 2937 C VAL 389 73. .718 41. .002 31. .216 1. .00 46. .95 1SG2938
ATOM 2938 O VAL 389 74. .837 41. .017 31, .722 1. .00 46. .95 1SG2939
ATOM 2939 N PHE 390 73. .506 40. .386 30 .043 1, .00 47. .91 1SG2940
ATOM 2940 CA PHE 390 74, .633 39 .673 29 .523 1, .00 47 .91 1SG2941
ATOM 2941 CB PHE 390 74. .337 38. .783 28. ,295 1. .00 47. .91 1SG2942
ATOM 2942 CG PHE 390 74. .174 39. .576 27. ,042 1. .00 47. .91 1SG2943
ATOM 2943 CD1 PHE 390 72, .987 40. .186 26. .715 1. .00 47. .91 1SG2944
ATOM 2944 CD2 PHE 390 75, .229 39. .687 26 .168 1. .00 47, .91 1SG2945
ATOM 2945 CE1 PHE 390 72. ,856 40. .902 25. .549 1. ,00 47. .91 1SG2946
ATOM 2946 CE2 PHE 390 75. .109 40. .399 24. .999 1. .00 47. .91 1SG2947
ATOM 2947 CZ PHE 390 73. .919 41, .010 24. .686 1. .00 47. .91 1SG2948
ATOM 2948 C PHE 390 75, .753 40, .607 29 .171 1, .00 47, .91 1SG2949
ATOM 2949 O PHE 390 76. .894 40. .392 29. .579 1, .00 47. .91 1SG2950
ATOM 2950 N GLU 391 75. .465 41. .682 28. ,416 1. .00 49. .07 1SG2951
ATOM 2951 CA GLU 391 76. .521 42. .553 27. .986 1. .00 49. .07 1SG2952
ATOM 2952 CB GLU 391 76. .036 43. ,683 27. .058 1. .00 49. ,07 1SG2953
ATOM 2953 CG GLU 391 75. .596 43 , ,225 25, .669 1. .00 49. .07 1SG2954
ATOM 2954 CD GLU 391 75. .147 44. ,451 24. ,888 1. ,00 49. .07 1SG2955
ATOM 2955 OEl GLU 391 75. .210 45. ,573 25. .459 1. .00 49. .07 1SG2956
ATOM 2956 OE2 GLU 391 74. .737 44. .283 23. .709 1. .00 49. .07 1SG2957
ATOM 2957 C GLU 391 77. .151 43. .246 29. .148 1. .00 49. .07 1SG2958
ATOM 2958 O GLU 391 78. ,374 43. .287 29. .253 1. .00 49. .07 1SG2959
ATOM 2959 N LYS 392 76. ,343 43. .867 30. .029 1. ,00 52. .01 1SG2960
ATOM 2960 CA LYS 392 76. 979 44. ,599 31. ,080 1. 00 52. 01 1SG2961
ATOM 2961 CB LYS 392 76. ,066 45. .669 31. .719 1. ,00 52. .01 1SG2962 ATOM 2962 CG LYS 392 76..762 46..500 32..800 1..00 52..01 1SG2963
ATOM 2963 CD LYS 392 75. .979 47. .748 33. .210 1. .00 52. .01 1SG2964
ATOM 2964 CE LYS 392 76, .671 48. .579 34. .293 1. .00 52. .01 1SG2965
ATOM 2965 NZ LYS 392 77. ,826 49, .300 33. .713 1. .00 52. .01 1SG2966
ATOM 2966 C LYS 392 77. .586 43. .701 32. .129 1. .00 52. .01 1SG2967
ATOM 2967 O LYS 392 78. .774 43, .856 32. .401 1. .00 52. .01 1SG2968
ATOM 2968 N PRO 393 76. .869 42, .811 32, .788 1. .00 52. .08 1SG2969
ATOM 2969 CA PRO 393 77 .566 41 .953 33 .716 1. .00 52 .08 1SG2970
ATOM 2970 CD PRO 393 75. .574 43. .192 33. .341 1. .00 52. .08 1SG2971
ATOM 2971 CB PRO 393 76. .578 41. .592 34. .830 1. .00 52, .08 1SG2972
ATOM 2972 CG PRO 393 75. .213 42. .067 34. .317 1. .00 52, .08 1SG2973
ATOM 2973 C PRO 393 78. .363 40. .765 33. .249 1. .00 52 .08 1SG2974
ATOM 2974 O PRO 393 79. .444 40, .549 33. .791 1, .00 52 .08 1SG2975
ATOM 2975 N LEU 394 77. .835 39 .954 32, .306 1. .00 49 .68 1SG2976
ATOM 2976 CA LEU 394 78. .466 38, .719 31. .903 1. .00 49, .68 1SG2977
ATOM 2977 CB LEU 394 77, .506 37, .794 31. .134 1. .00 49, .68 1SG2978
ATOM 2978 CG LEU 394 76. .328 37, .281 31. .983 1, .00 49 .68 1SG2979
ATOM 2979 CD2 LEU 394 75. .551 36, .175 31. .251 1, .00 49 .68 1SG2980
ATOM 2980 CD1 LEU 394 75. .425 38 .434 32. .446 1, .00 49 .68 1SG2981
ATOM 2981 C LEU 394 79 .701 38 .856 31 .052 1, .00 49 .68 1SG2982
ATOM 2982 O LEU 394 80. .741 38 .274 31, .355 1, .00 49 .68 1SG2983
ATOM 2983 N LEU 395 79. .626 39, .639 29. .963 1. .00 45, .82 1SG2984
ATOM 2984 CA LEU 395 80. .683 39, .704 28. .991 1. .00 45 .82 1SG2985
ATOM 2985 CB LEU 395 80. .345 40 .587 27. .776 1. .00 45 .82 1SG2986
ATOM 2986 CG LEU 395 79. .364 39 .932 26 .789 1 .00 45 .82 1SG2987
ATOM 2987 CD2 LEU 395 79, .892 38, .560 26. .337 1. .00 45. .82 1SG2988
ATOM 2988 CD1 LEU 395 79. .068 40, .859 25. .599 1. .00 45, .82 1SG2989
ATOM 2989 C LEU 395 81. .954 40 .228 29. .570 1. .00 45 .82 1SG2990
ATOM 2990 O LEU 395 83 .035 39 .755 29 .226 1. .00 45 .82 1SG2991
ATOM 2991 N ASP 396 81. .865 41, .224 30. .463 1. .00 37, .37 1SG2992
ATOM 2992 CA ASP 396 83 .046 41 .860 30. .964 1. .00 37 .37 1SG2993
ATOM 2993 CB ASP 396 82, .731 42 .974 31. .976 1. .00 37, .37 1SG2994
ATOM 2994 CG ASP 396 82, .075 44 .120 31. .219 1. .00 37 .37 1SG2995
ATOM 2995 OD1 ASP 396 82, .037 44. .053 29, .961 1. .00 37. .37 1SG2996
ATOM 2996 OD2 ASP 396 81, .607 45. .079 31, .888 1. .00 37. .37 1SG2997
ATOM 2997 C ASP 396 83, .932 40 .869 31, .656 1. .00 37 .37 1SG2998
ATOM 2998 O ASP 396 85 .145 40 .886 31 .462 1. .00 37 .37 1SG2999
ATOM 2999 N HIS 397 83. .359 39. .975 32. .482 1. .00 30, .59 1SG3000
ATOM 3000 CA HIS 397 84. .165 39. .055 33. .234 1. .00 30. .59 1SG3001
ATOM 3001 ND1 HIS 397 83. .360 39. .342 36, .472 1. .00 30. .59 1SG3002
ATOM 3002 CG HIS 397 8 .712 38 .989 35, .309 1. .00 30 .59 1SG3003
ATOM 3003 CB HIS 397 83. .341 38, .192 34, .204 1. .00 30 .59 1SG3004
ATOM 3004 NE2 HIS 397 81. .305 40. .178 36. .613 1. .00 30. .59 1SG3005
ATOM 3005 CD2 HIS 397 81, .457 39. .507 35. .412 1. ,00 30. .59 1SG3006
ATOM 3006 CE1 HIS 397 82, .474 40. .051 37. .215 1. .00 30. .59 1SG3007
ATOM 3007 C HIS 397 84, .897 38. .123 32. .319 1. .00 30. .59 1SG3008
ATOM 3008 O HIS 397 86, .084 37. .862 32. .513 1. ,00 30, .59 1SG3009
ATOM 3009 N LEU 398 84, .204 37. .593 31. .295 1. .00 26, .14 1SG3010
ATOM 3010 CA LEU 398 84. .789 36. .626 30. .408 1. ,00 26. .14 1SG3011
ATOM 3011 CB LEU 398 83. .788 36. .098 29. .364 1. ,00 26, .14 1SG3012
ATOM 3012 CG LEU 398 84. .395 35. .057 28. .405 1. 00 26. .14 1SG3013
ATOM 3013 CD2 LEU 398 83. .449 34. .764 27. .231 1. ,00 26. .14 1SG3014
ATOM 3014 CD1 LEU 398 84, .821 33, .788 29. .158 1. ,00 26, .14 1SG3015
ATOM 3015 C LEU 398 85, .936 37, .224 29, .660 1. ,00 26. .14 1SG3016
ATOM 3016 O LEU 398 86. .977 36. ,594 29. .487 1. 00 26, .14 1SG3017
ATOM 3017 N ASN 399 85. .772 38. .475 29. .202 1. 00 23. .39 1SG3018
ATOM 3018 CA ASN 399 86. .770 39. .138 28. ,407 1. .00 23. .39 1SG3019 ATOM 3019 CB ASN 399 86.320 40.,530 27.937 1.00 23.39 1SG3020
ATOM 3020 CG ASN 399 85. 210 40. ,324 26. 913 1. 00 23. 39 1SG3021
ATOM 3021 OD1 ASN 399 85. 305 39. .441 26. 063 1. 00 23. 39 1SG3022
ATOM 3022 ND2 ASN 399 84. ,130 41. .147 26. 997 1. 00 23. ,39 1SG3023
ATOM 3023 C ASN 399 88. .020 39. .292 29. .211 1. .00 23. .39 1SG3024
ATOM 3024 O ASN 399 89. .118 39. .281 28. .659 1. ,00 23. .39 1SG3025
ATOM 3025 N ALA 400 87. ,888 39. .453 30. .539 1. ,00 22. .50 1SG3026
ATOM 3026 CA ALA 400 89. ,040 39. .673 31. .366 1. .00 22. ,50 1SG3027
ATOM 3027 CB ALA 400 88. ,677 39. .846 32. .851 1. .00 22. ,50 1SG3028
ATOM 3028 C ALA 400 89. .974 38. .505 31. .263 1. .00 22. .50 1SG3029
ATOM 3029 O ALA 400 91. .187 38. .688 31. .167 1. ,00 22. .50 1SG3030
ATOM 3030 N LEU 401 89. .440 37. .268 31. .292 1. .00 23. .09 1SG3031
ATOM 3031 CA LEU 401 90. .282 36. .106 31. .210 1. .00 23. .09 1SG3032
ATOM 3032 CB LEU 401 89. .503 34. .793 31, .414 1. .00 23. .09 1SG3033
ATOM 3033 CG LEU 401 88. .869 34. .656 32, .810 1. .00 23. .09 1SG3034
ATOM 3034 CD2 LEU 401 89. .907 34. .869 33, .923 1, .00 23, .09 1SG3035
ATOM 3035 CD1 LEU 401 88. .111 33, .327 32 .947 1. .00 23, .09 1SG3036
ATOM 3036 C LEU 401 90. .916 36. .051 29, .856 1. .00 23, .09 1SG3037
ATOM 3037 O LEU 401 92, .106 35. .771 29 .718 1, .00 23, .09 1SG3038
ATOM 3038 N LEU 402 90, .128 36. .339 28 .807 1, .00 23, .66 1SG3039
ATOM 3039 CA LEU 402 90, .618 36, .272 27 .458 1. .00 23, .66 1SG3040
ATOM 3040 CB LEU 402 89, .532 36, .611 26 .423 1. .00 23 .66 1SG3041
ATOM 3041 CG LEU 402 88, .362 35, .611 26. .388 1. .00 23, .66 1SG3042
ATOM 3042 CD2 LEU 402 88. .863 34, .167 26. .217 1. .00 23, .66 1SG3043
ATOM 3043 CD1 LEU 402 87. .320 36, .011 25. .331 1. .00 23 , .66 1SG3044
ATOM 3044 C LEU 402 91. .717 37, .275 27. .308 1, .00 23, .66 1SG3045
ATOM 3045 O LEU 402 92. .716 37, .020 26. .637 1. .00 23, .66 1SG3046
ATOM 3046 N ALA 403 91. .545 38, .454 27. .927 1. .00 25, .02 1SG3047
ATOM 3047 CA ALA 403 92. .513 39, .508 27, .860 1. .00 25, .02 1SG3048
ATOM 3048 CB ALA 403 92. .057 40, .784 28 .588 1. .00 25, .02 1SG3049
ATOM 3049 C ALA 403 93, .782 39, .048 28 .509 1. .00 25, .02 1SG3050
ATOM 3050 O ALA 403 94, .869 39, .393 28 .050 1. .00 25, .02 1SG3051
ATOM 3051 N MET 404 93, .692 38 .271 29 .609 1. .00 27, .16 1SG3052
ATOM 3052 CA MET 404 94, .909 37, .853 30 .242 1. .00 27, .16 1SG3053
ATOM 3053 CB MET 404 94, .715 37 .027 31 .532 1 .00 27 .16 1SG3054
ATOM 3054 CG MET 404 94, .314 35 .568 31 .322 1. .00 27 .16 1SG3055
ATOM 3055 SD MET 404 94, .092 34 .615 32 .853 1 .00 27 .16 1SG3056
ATOM 3056 CE MET 404 93, .730 33 .048 32 .008 1 .00 27 .16 1SG3057
ATOM 3057 C MET 404 95 .647 37 .029 29 .237 1 .00 27 .16 1SG3058
ATOM 3058 O MET 404 96 .858 37 .171 29 .074 1 .00 27 .16 1SG3059
ATOM 3059 N GLY 405 94 .918 36 .160 28 .512 1 .00 29 .94 1SG3060
ATOM 3060 CA GLY 405 95 .524 35 .431 27 .437 1 .00 29 .94 1SG3061
ATOM 3061 C GLY 405 96 .050 34 .111 27 .893 1 .00 29 .94 1SG3062
ATOM 3062 O GLY 405 95 .903 33 .715 29 .049 1 .00 29 .94 1SG3063
ATOM 3063 N ILE 406 96 .674 33 .396 26 .934 1 .00 35 .47 1SG3064
ATOM 3064 CA ILE 406 97, .231 32, .095 27 .143 1. .00 35, .47 1SG3065
ATOM 3065 CB ILE 406 96, .537 31, .049 26 .325 1. .00 35, .47 1SG3066
ATOM 3066 CG2 ILE 406 96, .896 31, .282 24 .848 1. .00 35, .47 1SG3067
ATOM 3067 CGI ILE 406 96, .874 29 .646 26 .839 1. .00 35, .47 1SG3068
ATOM 3068 CD1 ILE 406 95, .974 28 .555 26 .259 1. .00 35, .47 1SG3069
ATOM 3069 C ILE 406 98, .661 32, .165 26 .693 1. .00 35, .47 1SG3070
ATOM 3070 O ILE 406 98, .985 32 .884 25 .750 1, .00 35 .47 1SG3071
ATOM 3071 N ALA 407 99, .566 31 .431 27 .371 1 .00 40 .33 1SG3072
ATOM 3072 CA ALA 407 100, .963 31 .492 27 .035 1, .00 40 .33 1SG3073
ATOM 3073 CB ALA 407 101, .876 30 .836 28 .085 1, .00 40 .33 1SG3074
ATOM 3074 C ALA 407 101, .213 30 .806 25 .725 1, .00 40 .33 1SG3075
ATOM 3075 O ALA 407 100, .558 29 .819 25 .392 1, .00 40 .33 1SG3076 ATOM 3076 N LEU 408 102..188 31..330 24..944 1.,00 46..48 1SG3077
ATOM 3077 CA LEU 408 102. .541 30. .750 23. .673 1. .00 46. .48 1SG3078
ATOM 3078 CB LEU 408 102. .749 31. .757 22. .526 1. .00 46. .48 1SG3079
ATOM 3079 CG LEU 408 101. .445 32. .339 21. .948 1. .00 46. .48 1SG3080
ATOM 3080 CD2 LEU 408 101. .713 33. .131 20. .659 1. .00 46. .48 1SG3081
ATOM 3081 CDl LEU 408 100. .671 33. ,149 22. .995 1. .00 46. .48 1SG3082
ATOM 3082 C LEU 408 103. .825 29. .995 23. .832 1. .00 46. .48 1SG3083
ATOM 3083 O LEU 408 104. .678 30. ,358 24. .638 1. .00 46. .48 1SG3084
ATOM 3084 N PRO 409 103. .950 28, .895 23. .133 1. .00 49. .49 1SG3085
ATOM 3085 CA PRO 409 105. .146 28. .100 23. .187 1. .00 49, .49 1SG3086
ATOM 3086 CD PRO 409 103. .201 28. .666 21, .909 1. .00 49, .49 1SG3087
ATOM 3087 CB PRO 409 104, .915 26. .967 22, .195 1. .00 49. .49 1SG3088
ATOM 3088 CG PRO 409 104 , .035 27. .638 21, .121 1. .00 49. .49 1SG3089
ATOM 3089 C PRO 409 106, .333 28. .901 22, .767 1. .00 49. .49 1SG3090
ATOM 3090 O PRO 409 106, .659 28. .880 21, .581 1. .00 49. .49 1SG3091
ATOM 3091 N GLY 410 107 .061 29, .526 23 .707 1. .00 47. .34 1SG3092
ATOM 3092 CA GLY 410 108. .197 30, .283 23 .272 1. .00 47. .34 1SG3093
ATOM 3093 C GLY 410 109. .324 29, .932 24, .182 1. .00 47. .34 1SG3094
ATOM 3094 O GLY 410 109. .154 29, .824 25, .395 1. .00 47, .34 1SG3095
ATOM 3095 N VAL 411 110. .522 29, .773 23, .593 1. .00 46. .04 1SG3096
ATOM 3096 CA VAL 411 111. .722 29, .453 24, .308 1, .00 46. .04 1SG3097
ATOM 3097 CB VAL 411 112, .924 29. .331 23, .419 1. .00 46. .04 1SG3098
ATOM 3098 CGI VAL 411 112 , .677 28. .220 22, .389 1. .00 46. .04 1SG3099
ATOM 3099 CG2 VAL 411 113 .203 30. .707 22 .791 1. .00 46 .04 1SG3100
ATOM 3100 C VAL 411 111, .994 30. .620 25 .195 1. .00 46. .04 1SG3101
ATOM 3101 O VAL 411 111, .344 31. .656 25 .084 1. .00 46, .04 1SG3102
ATOM 3102 N VAL 412 112. .941 30, .470 26 .137 1. .00 42, .34 1SG3103
ATOM 3103 CA VAL 412 113, .245 31, .543 27 .039 1. .00 42, .34 1SG3104
ATOM 3104 CB VAL 412 114, .073 31, .117 28 .215 1. .00 42, .34 1SG3105
ATOM 3105 CGI VAL 412 113. .264 30, .101 29 .039 1. .00 42, .34 1SG3106
ATOM 3106 CG2 VAL 412 115 .417 30 .576 27 .700 1 .00 42 .34 1SG3107
ATOM 3107 C VAL 412 114 .007 32. .613 26 .315 1 .00 42 .34 1SG3108
ATOM 3108 O VAL 412 114, .672 32, .364 25 .311 1, .00 42 .34 1SG3109
ATOM 3109 N ASN 413 113, .899 33 , .854 26 .834 1, .00 38 .95 1SG3110
ATOM 3110 CA ASN 413 114, .593 35, .014 26 .346 1. .00 38 .95 1SG3111
ATOM 3111 CB ASN 413 116, .123 34, .864 26 .403 1, .00 38 .95 1SG3112
ATOM 3112 CG ASN 413 116, .540 34, .856 27 .867 1, .00 38 .95 1SG3113
ATOM 3113 OD1 ASN 413 117, .143 33 , .899 28, .350 1, .00 38, .95 1SG3114
ATOM 3114 ND2 ASN 413 116, .212 35, .956 28 .595 1 .00 38 .95 1SG3115
ATOM 3115 C ASN 413 114, .230 35, .349 24 .932 1, .00 38 .95 1SG3116
ATOM 3116 O ASN 413 115, .071 35, .850 24 .187 1, .00 38 .95 1SG3117
ATOM 3117 N LEU 414 112, .972 35, .113 24 .513 1, .00 39 .20 1SG3118
ATOM 3118 CA LEU 414 112 , .630 35, .504 23 .174 1, .00 39, .20 1SG3119
ATOM 3119 CB LEU 414 112. .301 34. .321 22 .232 1, .00 39, .20 1SG3120
ATOM 3120 CG LEU 414 110. .819 33. .879 22, .151 1, .00 39, .20 1SG3121
ATOM 3121 CD2 LEU 414 109. .972 34. .803 21, .257 1. .00 39, .20 1SG3122
ATOM 3122 CDl LEU 414 110. .219 33. .616 23 .538 1. .00 39, .20 1SG3123
ATOM 3123 C LEU 414 111. .419 36. .376 23 .270 1, .00 39, .20 1SG3124
ATOM 3124 O LEU 414 110. .622 36. .249 24 .198 1, .00 39, .20 1SG3125
ATOM 3125 N HIS 415 111. .263 37. .307 22 .309 1, .00 38, .37 1SG3126
ATOM 3126 CA HIS 415 110. .115 38. .165 22 .292 1, .00 38, .37 1SG3127
ATOM 3127 ND1 HIS 415 112. .425 39. .784 24, .129 1. .00 38, .37 1SG3128
ATOM 3128 CG HIS 415 111. .078 39. .907 23, .872 1. .00 38, .37 1SG3129
ATOM 3129 CB HIS 415 110. .453 39. .646 22 .534 1. .00 38, .37 1SG3130
ATOM 3130 NE2 HIS 415 111. .470 40. .427 26 .031 1, .00 38, .37 1SG3131
ATOM 3131 CD2 HIS 415 110. .509 40. .300 25 .043 1, .00 38, .37 1SG3132
ATOM 3132 CE1 HIS 415 112. .604 40. .107 25, .435 1. .00 38. .37 1SG3133 ATOM 3133 C HIS 415 109..570 38..083 20.904 1.00 38..37 1SG3134
ATOM 3134 O HIS 415 110. ,313 37. ,832 19. .957 1. 00 38. .37 1SG3135
ATOM 3135 N TYR 416 108. .249 38. .291 20. .742 1. .00 40. .39 1SG3136
ATOM 3136 CA TYR 416 107. .685 38. ,220 19. .425 1. .00 40. .39 1SG3137
ATOM 3137 CB TYR 416 106. ,438 37. .324 19. ,330 1. 00 40. .39 1SG3138
ATOM 3138 CG TYR 416 106, .851 35. .914 19. .579 1. .00 40. .39 1SG3139
ATOM 3139 CDl TYR 416 107, .376 35. .149 18. .562 1. ,00 40, .39 1SG3140
ATOM 3140 CD2 TYR 416 106, .705 35. ,355 20. .827 1. ,00 40. .39 1SG3141
ATOM 3141 CE1 TYR 416 107, .756 33. .847 18. .787 1. ,00 40, .39 1SG3142
ATOM 3142 CE2 TYR 416 107. .082 34. .054 21. .059 1. .00 40, .39 1SG3143
ATOM 3143 CZ TYR 416 107. .607 33. .298 20. .038 1. .00 40. .39 1SG3144
ATOM 3144 OH TYR 416 107. .995 31. .962 20. .274 1. .00 40. .39 1SG3145
ATOM 3145 C TYR 416 107. .251 39. .604 19. .057 1. .00 40. .39 1SG3146
ATOM 3146 0 TYR 416 106. .587 40. .282 19. .840 1. .00 40 .39 1SG3147
ATOM 3147 N VAL 417 107. .638 40. .058 17. .846 1. .00 43, .63 1SG3148
ATOM 3148 CA VAL 417 107, ,303 41, .382 17. .399 1. ,00 43 .63 1SG3149
ATOM 3149 CB VAL 417 108, .478 42. .318 17. .365 1, .00 43 .63 1SG3150
ATOM 3150 CGI VAL 417 109, .027 42. .469 18. .793 1. ,00 43 .63 1SG3151
ATOM 3151 CG2 VAL 417 109. .509 41. .782 16, .356 1. .00 43, .63 1SG3152
ATOM 3152 C VAL 417 106, .787 41, .284 15. .996 1, .00 43 .63 1SG3153
ATOM 3153 0 VAL 417 106, .908 40, .248 15. .344 1. .00 43 .63 1SG3154
ATOM 3154 N ALA 418 106. .182 42, .386 15. .507 1. .00 45, .23 1SG3155
ATOM 3155 CA ALA 418 105. .598 42, .453 14, .193 1. .00 45 .23 1SG3156
ATOM 3156 CB ALA 418 106. .638 42, .617 13 , .069 1. .00 45 .23 1SG3157
ATOM 3157 C ALA 418 104. .784 41. .220 13. .901 1. .00 45 .23 1SG3158
ATOM 3158 0 ALA 418 105. .139 40. .480 12. .984 1. .00 45, .23 1SG3159
ATOM 3159 N PRO 419 103. .718 40. .928 14. .620 1, .00 47 .36 1SG3160
ATOM 3160 CA PRO 419 102. .958 39 .752 14. .289 1. .00 47 .36 1SG3161
ATOM 3161 CD PRO 419 103. .605 41. .237 16. .040 1, .00 47 .36 1SG3162
ATOM 3162 CB PRO 419 102, .378 39. .216 15. .598 1. .00 47 .36 1SG3163
ATOM 3163 CG PRO 419 102, .406 40. .424 16. .543 1. .00 47 .36 1SG3164
ATOM 3164 C PRO 419 101. .879 40. .011 13. .294 1. .00 47 .36 1SG3165
ATOM 3165 0 PRO 419 101, .487 41. .162 13. .105 1. .00 47 .36 1SG3166
ATOM 3166 N GLU 420 101, .385 38 .931 12. .659 1. .00 46 .49 1SG3167
ATOM 3167 CA GLU 420 100 .255 39 .024 11, .789 1, .00 46 .49 1SG3168
ATOM 3168 CB GLU 420 100. .587 39 .008 10. .288 1. .00 46 .49 1SG3169
ATOM 3169 CG GLU 420 101. .273 40, .288 9. .811 1. .00 46 .49 1SG3170
ATOM 3170 CD GLU 420 101. .382 40 .231 8 .296 1, .00 46 .49 1SG3171
ATOM 3171 OEl GLU 420 100, .912 39, .226 7. .698 1. .00 46 .49 1SG3172
ATOM 3172 OE2 GLU 420 101, .936 41, .200 7. .714 1. .00 46 .49 1SG3173
ATOM 3173 C GLU 420 99 .426 37 .817 12. .076 1. .00 46 .49 1SG3174
ATOM 3174 0 GLU 420 99, .944 36, .702 12 .140 1, .00 46 .49 1SG3175
ATOM 3175 N ILE 421 98, .108 38, .013 12. .271 1. .00 47 .91 1SG3176
ATOM 3176 CA ILE 421 97, .251 36, .898 12. .527 1. .00 47 .91 1SG3177
ATOM 3177 CB ILE 421 96 .379 37 .073 13. .751 1. .00 47 .91 1SG3178
ATOM 3178 CG2 ILE 421 97, .308 37. .127 14, .976 1. .00 47, .91 1SG3179
ATOM 3179 CGI ILE 421 95. .451 38, .299 13, .645 1. .00 47, .91 1SG3180
ATOM 3180 CDl ILE 421 96. .202 39, .630 13, .594 1. .00 47 .91 1SG3181
ATOM 3181 C ILE 421 96. .394 36 .722 11 .311 1. .00 47 .91 1SG3182
ATOM 3182 O ILE 421 95, .513 37, .531 11. .022 1. .00 47 .91 1SG3183
ATOM 3183 N PHE 422 96. .654 35 .645 10, .544 1, .00 50, .24 1SG3184
ATOM 3184 CA PHE 422 95. .928 35 .402 9, .333 1 .00 50 .24 1SG3185
ATOM 3185 CB PHE 422 96. .873 34. .878 8, .226 1. .00 50, .24 1SG3186
ATOM 3186 CG PHE 422 96. .289 35, .044 6. .861 1. .00 50 .24 1SG3187
ATOM 3187 CDl PHE 422 95. .213 34, .293 6 .440 1, .00 50, .24 1SG3188
ATOM 3188 CD2 PHE 422 96, .854 35. .940 5, .976 1. .00 50 .24 1SG3189
ATOM 3189 CE1 PHE 422 94. .704 34. .459 5, .171 1. .00 50, .24 1SG3190 H C ro ^ in io i^ oo cΛ O H C r ^ in io c^ oo o^ O H N ^ in vD t^ ∞ o H C ro ^ in io c^ oo o O H N ro ^ in io c^ oo σi O H cN r ^ in vo t^ CΛ σι CTι σι σ> σι CΛ σι cn o O O O O O O O O O H H H H H H H H H H <N CN CN CN CN CN CN CN CN CN rn rθ cΛ cη rθ rO rθ r cη r ^ τl< ri' 'tl< *lι *l< }i -fi
H CN CN CN CN CN CN CN CN CN CN C CN CN CN CN CN CN Γ^ CN CN CN CN CN CN CN CN C CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN
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H u α. ψ i. iii ^ iΛ m iΛ m m ij in iD iii io i iD io io iii ui io - Ui i'i n ni n n n n i'i n oi oi oi oi o o o o o o o o o o o o oi iΛ in iΛ in iΛ m o o
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Figure imgf000220_0001
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Figure imgf000220_0003
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Figure imgf000220_0004
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Figure imgf000220_0002
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H H H ri ri H H H H H M « M n N M M ( l. r< M M r) ri (N « M M M I M ( I N t. M N « n N M M « N I. I C>l (. M ri l r. M ( ( ( [ n n f , rι n n n n ιι n n n (i n n n n n n n n n n n n n n n m n n n n n n n n n n n rt n n n ιι n n n n n n n n n o O ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε s ε ε ε ε ε ε ε ε ε ε ε ε ε ε s ε ε ε ε ε ε ε s ε ε ε ε s ε ε ε ε s s
P P P d d P O P d P P P O P P P O O P P P P P P P O P P P P P P P P P P P P P P O P P P d d P P P P P P P P P O P H H H H H H H E-ι H H H E-ι E-ι H H H EH H E-< ι H H H EH EH H E-ι E-" EH EH H H EH E-< H E-ι H H E-< E-ι E-' E-ι H EH E-< H E-' H H E-' H EH tH H E-ι E-' H
ATOM 3247 CB VAL 429 98..326 31.,714 9..966 1.,00 35.,20 1SG3248
ATOM 3248 CGI VAL 429 99. .851 31. ,832 9. .795 1. 00 35. 20 1SG3249
ATOM 3249 CG2 VAL 429 97. .702 30. ,548 9. .180 1. 00 35. ,20 1SG3250
ATOM 3250 C VAL 429 98. .609 32. ,691 12. .145 1. 00 35. 20 1SG3251
ATOM 3251 0 VAL 429 98. .140 33. ,822 12. .016 1. ,00 35. ,20 1SG3252
ATOM 3252 N ILE 430 99. .660 32. .427 12. .944 1. ,00 34. ,93 1SG3253
ATOM 3253 CA ILE 430 100. .311 33. .499 13. ,627 1. .00 34. .93 1SG3254
ATOM 3254 CB ILE 430 100. .217 33. .436 15. .132 1. ,00 34. ,93 1SG3255
ATOM 3255 CG2 ILE 430 98, .743 33. .688 15. .498 1. ,00 34. .93 1SG3256
ATOM 3256 CGI ILE 430 100, .766 32. .122 15, .712 1. .00 34. .93 1SG3257
ATOM 3257 CDl ILE 430 99, .810 30. .948 15. ,505 1. 00 34. .93 1SG3258
ATOM 3258 C ILE 430 101. .736 33. .554 13. .179 1. ,00 34. .93 1SG3259
ATOM 3259 O ILE 430 102, .509 32. .613 13. .353 1. ,00 34. .93 1SG3260
ATOM 3260 N SER 431 102, .112 34. .690 12. .'558 1. ,00 31. .50 1SG3261
ATOM 3261 CA SER 431 103. .446 34, .844 12. .059 1. ,00 31. .50 1SG3262
ATOM 3262 CB SER 431 103, .511 35. .216 10. .570 1. .00 31, .50 1SG3263
ATOM 3263 OG SER 431 102. .961 36. .511 10, .369 1. .00 31, .50 1SG3264
ATOM 3264 C SER 431 104. .069 35. .972 12 , .801 1. .00 31 .50 1SG3265
ATOM 3265 O SER 431 103, .391 36. .926 13, .180 1. .00 31, .50 1SG3266
ATOM 3266 N SER 432 105, .389 35, .885 13. .047 1. .00 29, .56 1SG3267
ATOM 3267 CA SER 432 106. .003 36. .966 13 , .751 1. .00 29, .56 1SG3268
ATOM 3268 CB SER 432 105, .682 36, .979 15, .255 1. ,00 29, .56 1SG3269
ATOM 3269 OG SER 432 106, .198 35. .811 15, .876 1. .00 29, .56 1SG3270
ATOM 3270 C SER 432 107, .485 36, .879 13 , .606 1. .00 29, .56 1SG3271
ATOM 3271 O SER 432 108, .029 35. .908 13, .079 1, .00 29, .56 1SG3272
ATOM 3272 N GLY 433 108 .170 37. .938 14, .077 1. .00 29, .64 1SG3273
ATOM 3273 CA GLY 433 109. .599 37. .985 14, .059 1. .00 29 .64 1SG3274
ATOM 3274 C GLY 433 110, .002 37 .818 15 .484 1. .00 29, .64 1SG3275
ATOM 3275 O GLY 433 10 .245 38. .158 16 .392 1 .00 29 .64 1SG3276
ATOM 3276 N LEU 434 111. .210 37, .278 15, .722 1. .00 30, .27 1SG3277
ATOM 3277 CA LEU 434 Ill, .608 37, .052 17. .078 1. .00 30 .27 1SG3278
ATOM 3278 CB LEU 434 111, .949 35 .582 17, .375 1. .00 30 .27 1SG3279
ATOM 3279 CG LEU 434 110, .745 34, .636 17, .223 1, .00 30 .27 1SG3280
ATOM 3280 CD2 LEU 434 111, .065 33, .230 17 .756 1, .00 30 .27 1SG3281
ATOM 3281 CDl LEU 434 110 .230 34, .618 15 .775 1, .00 30 .27 1SG3282
ATOM 3282 C LEU 434 112, .833 37. .849 17 .364 1 .00 30 .27 1SG3283
ATOM 3283 O LEU 434 113 .655 38 .101 16 .485 1 .00 30 .27 1SG3284
ATOM 3284 N PHE 435 112 .962 38, .288 18 .629 1 .00 31 .88 1SG3285
ATOM 3285 CA PHE 435 114, .118 39, .009 19. .063 1, .00 31, .88 1SG3286
ATOM 3286 CB PHE 435 113 , .799 40, .428 19, .561 1 .00 31, .88 1SG3287
ATOM 3287 CG PHE 435 115, .075 41, .072 19, .981 1, .00 31, .88 1SG3288
ATOM 3288 CDl PHE 435 115, .891 41, .680 19, .053 1 .00 31 .88 1SG3289
ATOM 3289 CD2 PHE 435 115, .455 41 .072 21 .303 1 .00 31, .88 1SG3290
ATOM 3290 CE1 PHE 435 117 .068 42, .274 19, .439 1 .00 31 .88 1SG3291
ATOM 3291 CE2 PHE 435 116, .632 41 .665 21 .696 1 .00 31, .88 1SG3292
ATOM 3292 CZ PHE 435 117 .440 42, .268 20 .762 1, .00 31 .88 1SG3293
ATOM 3293 C PHE 435 114, .653 38 .245 20 .228 1 .00 31 .88 1SG3294
ATOM 3294 O PHE 435 113, .891 37, .802 21, .085 1, .00 31, .88 1SG3295
ATOM 3295 N TYR 436 115, .984 38. .066 20 .292 1 .00 33, .41 1SG3296
ATOM 3296 CA TYR 436 116, .540 37. .355 21, .405 1, .00 33, .41 1SG3297
ATOM 3297 CB TYR 436 117, .531 36. .239 21, .033 1 .00 33 .41 1SG3298
ATOM 3298 CG TYR 436 116, .741 35 .048 20 .624 1 .00 33, .41 1SG3299
ATOM 3299 CDl TYR 436 116, .208 34, .226 21, .590 1 .00 33 .41 1SG3300
ATOM 3300 CD2 TYR 436 116, .536 34 .744 19 .300 1 .00 33, .41 1SG3301
ATOM 3301 CE1 TYR 436 115 .476 33 .117 21, .244 1, .00 33 .41 1SG3302
ATOM 3302 CE2 TYR 436 115, .804 33 .636 18 .946 1 .00 33 .41 1SG3303
ATOM 3303 CZ TYR 436 115, .273 32, .822 19, .918 1, .00 33, .41 1SG3304 ATOM 3304 OH TYR 436 114.,521 31..685 19.,555 1..00 33..41 1SG3305
ATOM 3305 C TYR 436 117. ,276 38. .330 22. ,251 1. ,00 33. .41 1SG3306
ATOM 3306 O TYR 436 118. .086 39. .117 21. ,762 1. ,00 33. .41 1SG3307
ATOM 3307 N GLN 437 116. .985 38. .301 23. .563 1. .00 30. .85 1SG3308
ATOM 3308 CA GLN 437 117. .630 39. .193 24. ,473 1. .00 30. .85 1SG3309
ATOM 3309 CB GLN 437 117. .193 38. .984 25. .934 1. .00 30. .85 1SG3310
ATOM 3310 CG GLN 437 117. .874 39. .930 26. .924 1. .00 30. .85 1SG3311
ATOM 3311 CD GLN 437 117. .350 39. .606 28. .316 1. .00 30. .85 1SG3312
ATOM 3312 OEl GLN 437 116. .426 38. .810 28. .477 1. .00 30. .85 1SG3313
ATOM 3313 NE2 GLN 437 117. .952 40, .244 29. .355 1. .00 30. .85 1SG3314
ATOM 3314 C GLN 437 119. .121 38. .910 24. .382 1. .00 30. .85 1SG3315
ATOM 3315 O GLN 437 119. .519 37, .752 24. .678 1. .00 30. .85 1SG3316
ATOM 3316 OXT GLN 437 119. .880 39, .845 24. .015 1. .00 30. .85 1SG3317
END
TABLE 50 Atomic Coordinates ofBPIL 196-2 Molecular Model
ATOM 1 N SER 1 97. .943 12, .795 13. .749 1. .00 28. .80 1SG 2
ATOM 2 CA SER 1 96. .934 13, .751 13, .236 1. .00 28. .80 1SG 3
ATOM 3 CB SER 1 95. .831 13, .986 14 , .281 1, .00 28. .80 1SG 4
ATOM 4 OG SER 1 96, .375 14, .618 15, .431 1. .00 28. .80 1SG 5
ATOM 5 C SER 1 97, .559 15, .064 12 , .906 1, .00 28. .80 1SG 6
ATOM 6 O SER 1 98, .777 15, .221 12, .975 1, .00 28, .80 1SG 7
ATOM 7 N THR 2 96, .725 16, .047 12 , .520 1, .00 33, .53 1SG 8
ATOM 8 CA THR 2 97. .240 17, .338 12. .177 1. .00 33. .53 1SG 9
ATOM 9 CB THR 2 96, .256 18, .204 11, .449 1, .00 33 .53 1SG 10
ATOM 10 OGl THR 2 95. .125 18, .457 12 , .269 1, .00 33 .53 1SG 11
ATOM 11 CG2 THR 2 95. .826 17, .484 10, .160 1. .00 33 .53 1SG 12
ATOM 12 C THR 2 97, .596 18, .029 13 , .452 1, .00 33, .53 1SG 13
ATOM 13 O THR 2 96, .896 17, .916 14, .457 1, .00 33 .53 1SG 14
ATOM 14 N PRO 3 98, .703 18, .719 13 , .427 1. .00 38. .37 1SG 15
ATOM 15 CA PRO 3 99, .133 19, .423 14, .603 1. .00 38, .37 1SG 16
ATOM 16 CD PRO 3 99, .831 18, .249 12, .639 1, .00 38 .37 1SG 17
ATOM 17 CB PRO 3 100, .621 19, .705 14. .414 1. .00 38, .37 1SG 18
ATOM 18 CG PRO 3 101, .082 18, .588 13, .465 1. .00 38, .37 1SG 19
ATOM 19 C PRO 3 98, .335 20, .662 14 , .852 1, .00 38, .37 1SG 20
ATOM 20 O PRO 3 97, .932 21. .322 13 , .895 1, .00 38, .37 1SG 21
ATOM 21 N GLY 4 98, .083 20, .972 16, .137 1. .00 41, .14 1SG 22
ATOM 22 CA GLY 4 97, .374 22, .155 16, .534 1, .00 41, .14 1SG 23
ATOM 23 C GLY 4 98, .222 23, .359 16. .285 1, .00 41, .14 1SG 24
ATOM 24 O GLY 4 97, .711 24, .417 15. .925 1. .00 41, .14 1SG 25
ATOM 25 N THR 5 99, .543 23, .251 16. .541 1. .00 46, .30 1SG 26
ATOM 26 CA THR 5 100, .397 24, .378 16. .310 1, .00 46 .30 1SG 27
ATOM 27 CB THR 5 100, .820 25, .113 17, .550 1, .00 46, .30 1SG 28
ATOM 28 OGl THR 5 99. .688 25, .654 18, .214 1, .00 46, .30 1SG 29
ATOM 29 CG2 THR 5 101. .782 26, .242 17, .145 1, .00 46. .30 1SG 30
ATOM 30 C THR 5 101, .632 23, .912 15, .622 1. .00 46. .30 1SG 31
ATOM 31 O THR 5 102. .100 22, .796 15, .836 1, .00 46. .30 1SG 32
ATOM 32 N VAL 6 102, .176 24, .772 14, .742 1, .00 51, .31 1SG 33
ATOM 33 CA VAL 6 103, .393 24, .448 14 , .066 1. .00 51, .31 1SG 34
ATOM 34 CB VAL 6 103, .247 24, .198 12, .595 1, .00 51, .31 1SG 35
ATOM 35 CGI VAL 6 102, .561 22, .847 12, .380 1. .00 51, .31 1SG 36
ATOM 36 CG2 VAL 6 102, .458 25, .370 11, .995 1. .00 51. .31 1SG 37
ATOM 37 C VAL 6 104, .317 25, .602 14, .201 1, .00 51. .31 1SG 38
ATOM 38 O VAL 6 103 , .905 26, .759 14, .137 1, .00 51. .31 1SG 39
ATOM 39 N VAL 7 105. .608 25, .300 14. .420 1. .00 53. .33 1SG 40 ATOM 40 CA VAL 7 106..570 26.,351 14..464 1..00 53.,33 1SG 41
ATOM 41 CB VAL 7 107. .430 26. .387 15. .691 1. .00 53. .33 1SG 42
ATOM 42 CGI VAL 7 106. .559 26. .790 16. .884 1, ,00 53. .33 1SG 43
ATOM 43 CG2 VAL 7 108. .100 25. .019 15. .863 1, .00 53. .33 1SG 44
ATOM 44 C VAL 7 107, .461 26. .158 13. .294 1. .00 53. .33 1SG 45
ATOM 45 O VAL 7 107. .943 25. .056 13. .034 1. ,00 53. .33 1SG 46
ATOM 46 N ARG 8 107. .676 27. .247 12, .538 1. .00 53. .86 1SG 47
ATOM 47 CA ARG 8 108 .525 27. .175 11, .395 1, ,00 53. .86 1SG 48
ATOM 48 CB ARG 8 107. .849 27. ,704 10. .120 1. .00 53. .86 1SG 49
ATOM 49 CG ARG 8 106, .569 26. .947 9. .758 1. .00 53. .86 1SG 50
ATOM 50 CD ARG 8 106 .788 25. .783 8. .792 1. .00 53. .86 1SG 51
ATOM 51 NE ARG 8 107, .247 26. .360 7, .497 1. .00 53. .86 1SG 52
ATOM 52 CZ ARG 8 106, .336 26. .720 6. .548 1. .00 53. .86 1SG 53
ATOM 53 NH1 ARG 8 105 .000 26. .580 6. .792 1. .00 53. .86 1SG 54
ATOM 54 NH2 ARG 8 106, .764 27. .212 5. .348 1. .00 53. .86 1SG 55
ATOM 55 C ARG 8 109 .675 28. .072 11. .689 1. .00 53. .86 1SG 56
ATOM 56 0 ARG 8 109 .502 29, .261 11. .954 1. .00 53. .86 1SG 57
ATOM 57 N LEU 9 110, .895 27. .515 11. .653 1. .00 50. .17 1SG 58
ATOM 58 CA LEU 9 112 .046 28. .312 11. .938 1. .00 50. .17 1SG 59
ATOM 59 CB LEU 9 113 .084 2 .536 12 .767 1. .00 50. .17 1SG 60
ATOM 60 CG LEU 9 114. .170 28. .410 13. .413 1. .00 50. .17 1SG 61
ATOM 61 CD2 LEU 9 115. .351 27, .561 13. .909 1. .00 50. .17 1SG 62
ATOM 62 CDl LEU 9 113 .562 29 .283 14 .525 1. .00 50. .17 1SG 63
ATOM 63 C LEU 9 112, .638 28, .620 10, .598 1. .00 50. .17 1SG 64
ATOM 64 O LEU 9 112, .884 27 .717 9 .799 1, .00 50. .17 1SG 65
ATOM 65 N ASN 10 112 .856 29, .918 10 .309 1. .00 43. .15 1SG 66
ATOM 66 CA ASN 10 113, .357 30, .326 9, .026 1. .00 43. .15 1SG 67
ATOM 67 CB ASN 10 112 .845 31 .710 8 .586 1. .00 43. .15 1SG 68
ATOM 68 CG ASN 10 113 .098 31 .860 7 .093 1, .00 43 .15 1SG 69
ATOM 69 OD1 ASN 10 114, .056 32, .506 6, .670 1. .00 43. .15 1SG 70
ATOM 70 ND2 ASN 10 112, .222 31, .228 6 .266 1. .00 43. .15 1SG 71
ATOM 71 C ASN 10 114 .851 30 .362 9 .070 1 .00 43. .15 1SG 72
ATOM 72 O ASN 10 115 .462 30 .212 10 .126 1. .00 43, .15 1SG 73
ATOM 73 N LYS 11 115, .478 30, .566 7, .895 1. .00 37. .90 1SG 74
ATOM 74 CA LYS 11 116 .906 30 .573 7. .796 1. .00 37. .90 1SG 75
ATOM 75 CB LYS 11 117, .432 30, .791 6 .366 1. .00 37. .90 1SG 76
ATOM 76 CG LYS 11 117 .211 32 .202 5 .822 1. .00 37. .90 1SG 77
ATOM 77 CD LYS 11 118. .063 32, .497 4 .586 1. .00 37 .90 1SG 78
ATOM 78 CE LYS 11 119. .567 32, .377 4, .849 1. .00 37. .90 1SG 79
ATOM 79 NZ LYS 11 120 .318 32 .486 3 .579 1. .00 37, .90 1SG 80
ATOM 80 C LYS 11 117 .426 31 .681 8 .646 1 .00 37 .90 1SG 81
ATOM 81 O LYS 11 118. .472 31, .550 9 .279 1. .00 37, .90 1SG 82
ATOM 82 N ALA 12 116. .700 32, .810 8 .692 1. .00 33. .55 1SG 83
ATOM 83 CA ALA 12 117 .156 33 .915 9 .476 1. .00 33, .55 1SG 84
ATOM 84 CB ALA 12 116. .183 35, .106 9 .448 1. .00 33, .55 1SG 85
ATOM 85 C ALA 12 117, .249 33 .439 10 .889 1. .00 33, .55 1SG 86
ATOM 86 O ALA 12 118, .188 33, .775 11 .607 1. .00 33. .55 1SG 87
ATOM 87 N ALA 13 116, .255 32, .645 11, .326 1. .00 33. .68 1SG 88
ATOM 88 CA ALA 13 116, .224 32 .144 12 .667 1. .00 33, .68 1SG 89
ATOM 89 CB ALA 13 114 .938 31 .371 12 ,974 1, .00 33, .68 1SG 90
ATOM 90 C ALA 13 117. .362 31. .208 12, , 906 1. .00 33. .68 1SG 91
ATOM 91 O ALA 13 118. .016 31. .271 13 .945 1, .00 33. .68 1SG 92
ATOM 92 N LEU 14 117, .633 30 .301 11 .950 1, .00 35, .94 1SG 93
ATOM 93 CA LEU 14 118, .686 29. .359 12, .176 1. .00 35, .94 1SG 94
ATOM 94 CB LEU 14 118, .727 28, .183 11. .192 1. .00 35, .94 1SG 95
ATOM 95 CG LEU 14 117, .586 27, .187 11. .478 1. .00 35, .94 1SG 96
ATOM 96 CD2 LEU 14 117, .873 25, .806 10. .881 1. .00 35. .94 1SG 97 ATOM 97 CDl LEU 14 116.,215 27.,760 11.,095 1..00 35.,94 1SG 98
ATOM 98 C LEU 14 119. .997 30. .064 12. ,218 1. ,00 35. .94 1SG 99
ATOM 99 O LEU 14 120. .884 29. .680 12. .976 1. .00 35. .94 1SG 100
ATOM 100 N SER 15 120, .153 31, .128 11, .413 1, .00 38. .08 1SG 101
ATOM 101 CA SER 15 121. .398 31. .836 11. ,401 1, ,00 38. ,08 1SG 102
ATOM 102 CB SER 15 121, .377 33. .049 10. .457 1. .00 38. .08 1SG 103
ATOM 103 OG SER 15 122. .632 33. ,712 10. .484 1. .00 38. ,08 1SG 104
ATOM 104 C SER 15 121. .656 32. .341 12. .789 1, .00 38. .08 1SG 105
ATOM 105 O SER 15 122, .791 32. .327 13. .262 1. .00 38. .08 1SG 106
ATOM 106 N TYR 16 120. .598 32. .797 13. .479 1. .00 40. .16 1SG 107
ATOM 107 CA TYR 16 120, .726 33. .315 14. .812 1. .00 40. .16 1SG 108
ATOM 108 CB TYR 16 119, .390 33. .852 15. .354 1. .00 40. .16 1SG 109
ATOM 109 CG TYR 16 119. .629 34. .482 16. .684 1. .00 40. .16 1SG 110
ATOM 110 CDl TYR 16 119. .707 33. .722 17. ,828 1. .00 40. .16 1SG 111
ATOM 111 CD2 TYR 16 119, .767 35. .846 16. .783 1. .00 40, .16 1SG 112
ATOM 112 CE1 TYR 16 119 .923 34, .318 19, .050 1. .00 40, .16 1SG 113
ATOM 113 CE2 TYR 16 119', .983 36, .447 18, .000 1, .00 40, .16 1SG 114
ATOM 114 CZ TYR 16 120, .062 35. .683 19. .137 1. .00 40, .16 1SG 115
ATOM 115 OH TYR 16 120, .283 36. .299 20. .386 1. .00 40, .16 1SG 116
ATOM 116 C TYR 16 121 .159 32, .194 15, .704 1, .00 40, .16 1SG 117
ATOM 117 O TYR 16 122 .032 32, .362 16. .554 1. .00 40, .16 1SG 118
ATOM 118 N VAL 17 120, .551 31. .008 15. .516 1. .00 40, .03 1SG 119
ATOM 119 CA VAL 17 120 .846 29. .864 16. .329 1, .00 40 .03 1SG 120
ATOM 120 CB VAL 17 120, .052 28. .656 15. .924 1, .00 40, .03 1SG 121
ATOM 121 CGI VAL 17 120 .526 27. .453 16. .756 1, .00 40 .03 1SG 122
ATOM 122 CG2 VAL 17 118, .556 28. , 976 16. .084 1. .00 40, .03 1SG 123
ATOM 123 C VAL 17 122 .288 29. .532 16. .142 1, .00 40, .03 1SG 124
ATOM 124 O VAL 17 122 .988 29. .160 17. .081 1, .00 40 .03 1SG 125
ATOM 125 N SER 18 122 .777 29, .650 14. .901 1, .00 39, .96 1SG 126
ATOM 126 CA SER 18 124 .147 29. .339 14. .638 1, .00 39 .96 1SG 127
ATOM 127 CB SER 18 124, .522 29. .579 13. .177 1. .00 39. .96 1SG 128
ATOM 128 OG SER 18 125 .914 29, .393 12. .994 1. .00 39 .96 1SG 129
ATOM 129 C SER 18 125 .014 30, .253 15. .425 1, .00 39. .96 1SG 130
ATOM 130 O SER 18 125 .970 29. .816 16. .062 1, .00 39 .96 1SG 131
ATOM 131 N GLU 19 124 .685 31. .557 15. .415 1. .00 39. .74 1SG 132
ATOM 132 CA GLU 19 125 .514 32, .527 16, .064 1, .00 39. .74 1SG 133
ATOM 133 CB GLU 19 124 .987 33 .961 15, .896 1 .00 39 .74 1SG 134
ATOM 134 CG GLU 19 125, .089 34, .466 14 , .455 1. .00 39. .74 1SG 135
ATOM 135 CD GLU 19 124 .538 35, .882 14 , .406 1, .00 39, .74 1SG 136
ATOM 136 OEl GLU 19 124 .079 36 .377 15, .470 1 .00 39 .74 1SG 137
ATOM 137 OE2 GLU 19 124 .569 36, .487 13 , .302 1. .00 39, .74 1SG 138
ATOM 138 C GLU 19 125 .568 32 .223 17 .522 1 .00 39 .74 1SG 139
ATOM 139 O GLU 19 126, .634 32, .279 18. .132 1. .00 39, .74 1SG 140
ATOM 140 N ILE 20 124 .418 31, .880 18. .126 1. .00 40, .54 1SG 141
ATOM 141 CA ILE 20 124, .446 31, .610 19. .529 1. .00 40. .54 1SG 142
ATOM 142 CB ILE 20 123 .096 31, .339 20. .146 1, .00 40 .54 1SG 143
ATOM 143 CG2 ILE 20 122 .213 32, .573 19. .903 1. .00 40, .54 1SG 144
ATOM 144 CGI ILE 20 122, .486 30, .034 19. .615 1. .00 40, .54 1SG 145
ATOM 145 CDl ILE 20 121 .268 29 .543 20, .396 1. .00 40, .54 1SG 146
ATOM 146 C ILE 20 125 .290 30, .402 19, .739 1. .00 40, .54 1SG 147
ATOM 147 O ILE 20 126, .078 30, .358 20. .672 1. .00 40, .54 1SG 148
ATOM 148 N GLY 21 125, .155 29. .368 18. .893 1. .00 42. .42 1SG 149
ATOM 149 CA GLY 21 125 .931 28, .184 19. .129 1. .00 42. .42 1SG 150
ATOM 150 C GLY 21 127 .398 28 .452 18. .976 1. .00 42. .42 1SG 151
ATOM 151 O GLY 21 128 .200 28, .076 19. .829 1. .00 42. .42 1SG 152
ATOM 152 N LYS 22 127, .782 29, .169 17. .908 1. .00 45. .79 1SG 153
ATOM 153 CA LYS 22 129, .163 29, .347 17. ,568 1. .00 45. .79 1SG 154 ATOM 154 CB LYS 22 129..330 30..304 16..376 1..00 45..79 1SG 155
ATOM 155 CG LYS 22 128, .548 29. .867 15 .137 1. .00 45. .79 1SG 156
ATOM 156 CD LYS 22 128, .328 30. .990 14. .121 1. .00 45. .79 1SG 157
ATOM 157 CE LYS 22 128 .154 32, .373 14 .753 1. .00 45. .79 1SG 158
ATOM 158 NZ LYS 22 128, .033 33. .401 13, .694 1. .00 45. .79 1SG 159
ATOM 159 C LYS 22 129, .885 29. .972 18 .715 1. .00 45. .79 1SG 160
ATOM 160 O LYS 22 130, .968 29, .516 19 .083 1, .00 45. .79 1SG 161
ATOM 161 N ALA 23 129 .300 31, .012 19 .339 1. .00 49. .45 1SG 162
ATOM 162 CA ALA 23 130, .050 31, .698 20 .351 1. .00 49. .45 1SG 163
ATOM 163 CB ALA 23 129 .331 32, .942 20 .910 1, .00 49. .45 1SG 164
ATOM 164 C ALA 23 130, .387 30, .746 21 .464 1. .00 49. .45 1SG 165
ATOM 165 O ALA 23 131 .543 30, .692 21 .875 1. .00 49. .45 1SG 166
ATOM 166 N PRO 24 129, .461 29. .976 21 .969 1. .00 53. .76 1SG 167
ATOM 167 CA PRO 24 129 .879 29. .009 22 .936 1. .00 53, .76 1SG 168
ATOM 168 CD PRO 24 128, .223 30, .583 22 .419 1. .00 53. .76 1SG 169
ATOM 169 CB PRO 24 128, .608 28, .496 23 .599 1. .00 53, .76 1SG 170
ATOM 170 CG PRO 24 127, .729 29, .755 23, .618 1, .00 53. .76 1SG 171
ATOM 171 C PRO 24 130 .787 27, .965 22 .382 1. .00 53, .76 1SG 172
ATOM 172 O PRO 24 131, .514 27, .356 23 .164 1, .00 53, .76 1SG 173
ATOM 173 N LEU 25 130 .755 27, .708 21 .062 1, .00 55, .31 1SG 174
ATOM 174 CA LEU 25 131, .684 26, .751 20 .535 1, .00 55, .31 1SG 175
ATOM 175 CB LEU 25 131 .514 26, .418 19 .038 1, .00 55, .31 1SG 176
ATOM 176 CG LEU 25 130, .525 25, .281 18 .711 1 .00 55. .31 1SG 177
ATOM 177 CD2 LEU 25 130 .594 24, .921 17 .218 1, .00 55, .31 1SG 178
ATOM 178 CDl LEU 25 129, .097 25, .575 19, .180 1, .00 55, .31 1SG 179
ATOM 179 C LEU 25 133 .075 27, .271 20 .689 1, .00 55. .31 1SG 180
ATOM 180 O LEU 25 133. .977 26, .526 21 .064 1 .00 55 .31 1SG 181
ATOM 181 N GLN 26 133 .273 28, .583 20 .459 1, .00 55, .34 1SG 182
ATOM 182 CA GLN 26 134. .592 29, .147 20, .403 1, .00 55, .34 1SG 183
ATOM 183 CB GLN 26 134 .592 30, .659 20 .123 1, .00 55, .34 1SG 184
ATOM 184 CG GLN 26 134. .000 31 .002 18 .756 1 .00 55 .34 1SG 185
ATOM 185 CD GLN 26 134 .724 30 .158 17 .717 1, .00 55, .34 1SG 186
ATOM 186 OEl GLN 26 134 .117 29 .307 17 .070 1. .00 55 .34 1SG 187
ATOM 187 NE2 GLN 26 136 .054 30. .390 17, .556 1, .00 55, .34 1SG 188
ATOM 188 C GLN 26 135 .328 28 .919 21 .683 1, .00 55, .34 1SG 189
ATOM 189 0 GLN 26 136. .524 28. .634 21, .666 1, .00 55. .34 1SG 190
ATOM 190 N ARG 27 134 .644 29 .019 22 .833 1, .00 53, .99 1SG 191
ATOM 191 CA ARG 27 135 .344 28. .847 24, .072 1, .00 53. .99 1SG 192
ATOM 192 CB ARG 27 134 .440 28 .998 25 .309 1, .00 53. .99 1SG 193
ATOM 193 CG ARG 27 133. .282 28. .001 25, .365 1. .00 53. .99 1SG 194
ATOM 194 CD ARG 27 132 .403 28 .176 26 .604 1, .00 53, .99 1SG 195
ATOM 195 NE ARG 27 131, .267 27, .219 26, .497 1. .00 53. .99 1SG 196
ATOM 196 CZ ARG 27 130 .222 27, .311 27, .370 1. .00 53. .99 1SG 197
ATOM 197 NHl ARG 27 130, .228 28, .273 28. .339 1. .00 53. .99 1SG 198
ATOM 198 NH2 ARG 27 129, .170 26, .446 27, .273 1. .00 53. .99 1SG 199
ATOM 199 C ARG 27 135, .928 27, .470 24, .086 1. .00 53. .99 1SG 200
ATOM 200 O ARG 27 137, .036 27, .259 24, .575 1. .00 53. .99 1SG 201
ATOM 201 N ALA 28 135, .195 26, .497 23 .521 1, .00 52. .56 1SG 202
ATOM 202 CA ALA 28 135, .610 25, .124 23, .501 1. .00 52. .56 1SG 203
ATOM 203 CB ALA 28 134, .593 24, .207 22. .800 1. .00 52. ,56 1SG 204
ATOM 204 C ALA 28 136, .909 25, .010 22, .757 1. .00 52. .56 1SG 205
ATOM 205 O ALA 28 137, .774 24, .217 23 .124 1, .00 52. .56 1SG 206
ATOM 206 N LEU 29 137, .091 25, .838 21, .714 1. .00 54. .46 1SG 207
ATOM 207 CA LEU 29 138, .239 25. .806 20, .849 1. .00 54. .46 1SG 208
ATOM 208 CB LEU 29 138, .193 26, .808 19, .682 1. .00 54. .46 1SG 209
ATOM 209 CG LEU 29 137. .240 26, .377 18, .550 1. .00 54. ,46 1SG 210
ATOM 210 CD2 LEU 29 137. .456 27. .220 17, .286 1. .00 54. ,46 1SG 211 ATOM 211 CDl LEU 29 135..779 26..351 19. Oil 1.00 54.46 1SG 212
ATOM 212 C LEU 29 139, .491 26. .055 21. .633 1. .00 54. ,46 1SG 213
ATOM 213 O LEU 29 140, .589 25. .767 21. .162 1. .00 54. ,46 1SG 214
ATOM 214 N GLN 30 139, .355 26. .571 22. ,865 1. .00 56. ,01 1SG 215
ATOM 215 CA GLN 30 140. .461 26. .956 23. ,696 1. 00 56. .01 1SG 216
ATOM 216 CB GLN 30 140, .050 27. .347 25. .126 1. ,00 56. .01 1SG 217
ATOM 217 CG GLN 30 139, .299 28. .678 25. .196 1. ,00 56. .01 1SG 218
ATOM 218 CD GLN 30 138, .947 28. .958 26. ,650 1. .00 56. .01 1SG 219
ATOM 219 OEl GLN 30 139, .156 28. .123 27. .529 1. .00 56. .01 1SG 220
ATOM 220 NE2 GLN 30 138, .395 30. .173 26. .914 1. ,00 56. .01 1SG 221
ATOM 221 C GLN 30 141, .452 25. .835 23. .786 1. ,00 56. .01 1SG 222
ATOM 222 O GLN 30 142. .592 26. .100 24. .162 1. .00 56. .01 1SG 223
ATOM 223 N VAL 31 141, .033 24, .578 23. .493 1. .00 59. .83 1SG 224
ATOM 224 CA VAL 31 141. .845 23, .380 23. .534 1. ,00 59. .83 1SG 225
ATOM 225 CB VAL 31 141, .332 22. .279 22. .652 1. ,00 59. .83 1SG 226
ATOM 226 CGI VAL 31 141 .413 22. .744 21, .188 1. .00 59. .83 1SG 227
ATOM 227 CG2 VAL 31 142, .139 21, .004 22 , .945 1. .00 59. .83 1SG 228
ATOM 228 C VAL 31 143, .255 23 , .686 23. .121 1. .00 59. .83 1SG 229
ATOM 229 O VAL 31 143, .511 24. .599 22. .338 1. ,00 59. .83 1SG 230
ATOM 230 N THR 32 144 .215 22. .930 23. .690 1. .00 61, .35 1SG 231
ATOM 231 CA THR 32 145, .614 23, .213 23. .535 1. .00 61. .35 1SG 232
ATOM 232 CB THR 32 146, .502 22, .280 24 , .308 1. .00 61. .35 1SG 233
ATOM 233 OGl THR 32 147 .851 22, .720 24. .243 1, .00 61, .35 1SG 234
ATOM 234 CG2 THR 32 146 .374 20, .863 23, .720 1. .00 61, .35 1SG 235
ATOM 235 C THR 32 146 .038 23, .158 22, .105 1. .00 61, .35 1SG 236
ATOM 236 O THR 32 145. .789 22, .190 21. .391 1. .00 61. .35 1SG 237
ATOM 237 N VAL 33 146 .691 24, .247 21, .659 1, .00 61, .18 1SG 238
ATOM 238 CA VAL 33 147, .251 24 , .342 20, .346 1. .00 61, .18 1SG 239
ATOM 239 CB VAL 33 146, .262 24 , .741 19, .291 1. .00 61, .18 1SG 240
ATOM 240 CGI VAL 33 145 .748 26 .154 19 .612 1. .00 61, .18 1SG 241
ATOM 241 CG2 VAL 33 146 .942 24, .628 17, .916 1, .00 61, .18 1SG 242
ATOM 242 C VAL 33 148, .267 25. .432 20, .435 1. .00 61, .18 1SG 243
ATOM 243 O VAL 33 148, .219 26. .265 21, .338 1. .00 61. .18 1SG 244
ATOM 244 N PRO 34 149 .207 25. .432 19, .539 1, .00 60. .55 1SG 245
ATOM 245 CA PRO 34 150 .195 26. .475 19, .551 1. .00 60. .55 1SG 246
ATOM 246 CD PRO 34 149, .750 24. .183 19, .036 1. .00 60. .55 1SG 247
ATOM 247 CB PRO 34 151 .416 25 .921 18 .812 1 .00 60. .55 1SG 248
ATOM 248 CG PRO 34 150 .919 24. .625 18, .146 1. .00 60. .55 1SG 249
ATOM 249 C PRO 34 149, .620 27. .709 18, .938 1. .00 60. .55 1SG 250
ATOM 250 O PRO 34 148, .602 27. .618 18, .255 1, .00 60. .55 1SG 251
ATOM 251 N HIS 35 150 .239 28. .878 19, .181 1, .00 57. .03 1SG 252
ATOM 252 CA HIS 35 149, .715 30. .079 18, .604 1, .00 57. .03 1SG 253
ATOM 253 NDl HIS 35 151, .937 31. .090 20, .943 1. .00 57. .03 1SG 254
ATOM 254 CG HIS 35 151 .264 31. .634 19, .872 1. .00 57, .03 1SG 255
ATOM 255 CB HIS 35 149, .841 31. .309 19, .520 1, .00 57. .03 1SG 256
ATOM 256 NE2 HIS 35 153, .365 32. .455 19, .921 1. .00 57. .03 1SG 257
ATOM 257 CD2 HIS 35 152 .150 32, .465 19 .259 1. .00 57, .03 1SG 258
ATOM 258 CE1 HIS 35 153 .189 31, .615 20, .926 1. .00 57, .03 1SG 259
ATOM 259 C HIS 35 150. .501 30. .360 17, .375 1. .00 57, .03 1SG 260
ATOM 260 O HIS 35 151. .722 30. .214 17. .355 1. .00 57. .03 1SG 261
ATOM 261 N PHE 36 149 .801 30, .753 16, .298 1, .00 55, .90 1SG 262
ATOM 262 CA PHE 36 150 .505 31. .071 15, .099 1. .00 55. .90 1SG 263
ATOM 263 CB PHE 36 149, .864 30. .458 13, .848 1. .00 55. .90 1SG 264
ATOM 264 CG PHE 36 150 .077 29, .001 14, .051 1. .00 55. .90 1SG 265
ATOM 265 CDl PHE 36 151, .248 28. .408 13, .640 1. .00 55. .90 1SG 266
ATOM 266 CD2 PHE 36 149, .120 28. .236 14. .677 1. .00 55. .90 1SG 267
ATOM 267 CE1 PHE 36 151. .459 27. .065 13. .836 1. ,00 55. .90 1SG 268 ATOM 268 CE2 PHE 36 149..325 26..892 14..877 1..00 55.,90 1SG 269
ATOM 269 CZ PHE 36 150. .496 26 .309 14, .456 1. .00 55. .90 1SG 270
ATOM 270 C PHE 36 150 .509 32 .552 15, .011 1. .00 55. .90 1SG 271
ATOM 271 O PHE 36 149. .459 33. .191 15, .010 1. .00 55. .90 1SG 272
ATOM 272 N LEU 37 151. .722 33. .128 14. .950 1. .00 54. .02 1SG 273
ATOM 273 CA LEU 37 151 .857 34 .550 14. .963 1. .00 54, .02 1SG 274
ATOM 274 CB LEU 37 153 , .020 35 .034 15, .843 1. .00 54, .02 1SG 275
ATOM 275 CG LEU 37 153. .183 36 .564 15, .861 1. .00 54, .02 1SG 276
ATOM 276 CD2 LEU 37 154. .481 36 .981 16. .571 1. .00 54. .02 1SG 277
ATOM 277 CDl LEU 37 151 .938 37 .246 16. .449 1. .00 54, .02 1SG 278
ATOM 278 C LEU 37 152. .132 35 .023 13 , .581 1. .00 54, .02 1SG 279
ATOM 279 O LEU 37 152 .841 34 .378 12 .810 1. .00 54, .02 1SG 280
ATOM 280 N ASP 38 151. .533 36 .178 13. .236 1. .00 51, .14 1SG 281
ATOM 281 CA ASP 38 151. .736 36 .775 11. .955 1. .00 51, .14 1SG 282
ATOM 282 CB ASP 38 150 .435 37 .051 11. .188 1. .00 51, .14 1SG 283
ATOM 283 CG ASP 38 150 .783 37 .447 9 .759 1. .00 51 .14 1SG 284
ATOM 284 OD1 ASP 38 151. .906 37. .099 9. .306 1. .00 51 .14 1SG 285
ATOM 285 OD2 ASP 38 149, .929 38 .099 9, .102 1. .00 51, .14 1SG 286
ATOM 286 C ASP 38 152 .360 38 .110 12. .197 1, .00 51 .14 1SG 287
ATOM 287 O ASP 38 152, .380 38 .602 13. .323 1. .00 51 .14 1SG 288
ATOM 288 N TRP 39 152, .904 38 .715 11. .125 1, .00 49 .50 1SG 289
ATOM 289 CA TRP 39 153, .496 40 .018 11. .175 1. .00 49 .50 1SG 290
ATOM 290 CB TRP 39 154, .997 40 .015 10, .842 1. .00 49 .50 1SG 291
ATOM 291 CG TRP 39 155, .833 39 .278 11. .862 1. .00 49 .50 1SG 292
ATOM 292 CD2 TRP 39 156, .543 39 .900 12 .945 1, .00 49 .50 1SG 293
ATOM 293 CDl TRP 39 156 .075 37 .939 11. .962 1. .00 49 .50 1SG 294
ATOM 294 NE1 TRP 39 156, .883 37 .686 13. .044 1. .00 49, .50 1SG 295
ATOM 295 CE2 TRP 39 157 .180 38 .885 13. .657 1. .00 49 .50 1SG 296
ATOM 296 CE3 TRP 39 156 .653 41 .210 13 .317 1. .00 49 .50 1SG 297
ATOM 297 CZ2 TRP 39 157, .941 39. .164 14. .757 1. .00 49, .50 1SG 298
ATOM 298 CZ3 TRP 39 157, .422 41 .487 14, .426 1. .00 49 .50 1SG 299
ATOM 299 CH2 TRP 39 158, .053 40 .484 15, .133 1. .00 49 .50 1SG 300
ATOM 300 C TRP 39 152, .793 40 .784 10, .104 1. .00 49 .50 1SG 301
ATOM 301 O TRP 39 151, .925 40. .240 9. .424 1. .00 49, .50 1SG 302
ATOM 302 N SER 40 153, .101 42 .083 9, .935 1, .00 43 .37 1SG 303
ATOM 303 CA SER 40 152 , .382 42. .753 8. .896 1. .00 43 .37 1SG 304
ATOM 304 CB SER 40 151, .053 43. .361 9, .369 1. .00 43 .37 1SG 305
ATOM 305 OG SER 40 150. .317 43 , .874 8, .269 1. .00 43 .37 1SG 306
ATOM 306 C SER 40 153. .234 43 .840 8, .330 1. .00 43 .37 1SG 307
ATOM 307 O SER 40 154. .364 44. .060 8, .764 1. .00 43, .37 1SG 308
ATOM 308 N GLY 41 152, .703 44 .528 7, .301 1. .00 39 .48 1SG 309
ATOM 309 CA GLY 41 153 , .427 45. .574 6, .646 1. .00 39 .48 1SG 310
ATOM 310 C GLY 41 153. .274 46. .822 7. .446 1. .00 39. .48 1SG 311
ATOM 311 O GLY 41 152. .449 46. .903 8. .353 1. .00 39. .48 1SG 312
ATOM 312 N GLU 42 154. .074 47. .846 7, .100 1. .00 39. .62 1SG 313
ATOM 313 CA GLU 42 154. .049 49. .079 7. .826 1. .00 39. .62 1SG 314
ATOM 314 CB GLU 42 155. .095 50. .091 7. .321 1. ,00 39. .62 1SG 315
ATOM 315 CG GLU 42 155. .224 51. .349 8. .188 1. .00 39. .62 1SG 316
ATOM 316 CD GLU 42 154. .078 52. .300 7. .862 1. .00 39. .62 1SG 317
ATOM 317 OEl GLU 42 153. .933 52. .670 6. .668 1. .00 39. .62 1SG 318
ATOM 318 OE2 GLU 42 153. .325 52. .661 8. .808 1. ,00 39. .62 1SG 319
ATOM 319 C GLU 42 152. .702 49. .707 7. .672 1. .00 39, .62 1SG 320
ATOM 320 O GLU 42 152. .143 50. .230 8. .635 1. ,00 39. .62 1SG 321
ATOM 321 N ALA 43 152. .145 49. .682 6. .448 1. .00 40. .49 1SG 322
ATOM 322 CA ALA 43 150. .886 50. .330 6. .226 1. .00 40. .49 1SG 323
ATOM 323 CB ALA 43 150. .426 50. .260 4. .760 1. 00 40. ,49 1SG 324
ATOM 324 C ALA 43 149. .831 49. .664 7. .047 1. ,00 40. .49 1SG 325 ATOM 325 O ALA 43 149.,032 50..334 7..700 1.,00 40..49 1SG 326
ATOM 326 N LEU 44 149. .804 48. .317 7. .036 1. ,00 47. .19 1SG 327
ATOM 327 CA LEU 44 148. .781 47. .611 7. .751 1. .00 47. .19 1SG 328
ATOM 328 CB LEU 44 148. ,809 46. .092 7. .525 1. .00 47. .19 1SG 329
ATOM 329 CG LEU 44 148. ,548 45. .668 6. .073 1, .00 47. .19 1SG 330
ATOM 330 CD2 LEU 44 149. .663 46. .166 5. .141 1. .00 47. .19 1SG 331
ATOM 331 CDl LEU 44 147. .140 46. .079 5, .617 1. .00 47, .19 1SG 332
ATOM 332 C LEU 44 148. ,932 47. .801 9. .226 i, .00 47, .19 1SG 333
ATOM 333 O LEU 44 147. .953 48. .114 9. .901 1. .00 47. .19 1SG 334
ATOM 334 N GLN 45 150. .172 47. .625 9. .741 1. .00 52. .53 1SG 335
ATOM 335 CA GLN 45 150. .498 47, .646 11. .146 1. .00 52, .53 1SG 336
ATOM 336 CB GLN 45 149. .581 48 , .506 12. .052 1, .00 52, .53 1SG 337
ATOM 337 CG GLN 45 149. .981 49. .983 12. .142 1. .00 52. .53 1SG 338
ATOM 338 CD GLN 45 149. .209 50, .803 11. .124 1. .00 52, .53 1SG 339
ATOM 339 OEl GLN 45 147. .994 50, .965 11, .236 1. .00 52, .53 1SG 340
ATOM 340 NE2 GLN 45 149, .934 51 .354 10, .115 1. .00 52 .53 1SG 341
ATOM 341 C GLN 45 150, .512 46. .220 11. .609 1. .00 52 .53 1SG 342
ATOM 342 O GLN 45 149, .994 45. .367 10, .891 1. .00 52, .53 1SG 343
ATOM 343 N PRO 46 151 .090 45. .889 12, .745 1. .00 55 .07 1SG 344
ATOM 344 CA PRO 46 151 .185 4 .516 13 .164 1. .00 55 .07 1SG 345
ATOM 345 CD PRO 46 151, .258 46, .800 13, .870 1, .00 55 .07 1SG 346
ATOM 346 CB PRO 46 151, .794 44, .545 14, .561 1. .00 55 .07 1SG 347
ATOM 347 CG PRO 46 151 .325 45 .901 15, .115 1. .00 55 .07 1SG 348
ATOM 348 C PRO 46 149. .838 43. .879 13. .198 1. .00 55, .07 1SG 349
ATOM 349 O PRO 46 148. .870 44. .527 13. .594 1, .00 55, .07 1SG 350
ATOM 350 N THR 47 149. .750 42. .609 12. .774 1. .00 58, .84 1SG 351
ATOM 351 CA THR 47 148. .483 41. .961 12. .817 1. .00 58, .84 1SG 352
ATOM 352 CB THR 47 147. .785 41. .948 11, .478 1, .00 58, .84 1SG 353
ATOM 353 OGl THR 47 146. .494 41. .378 11, .579 1. .00 58 .84 1SG 354
ATOM 354 CG2 THR 47 148. .646 41. .149 10. .482 1. .00 58, .84 1SG 355
ATOM 355- C THR 47 148. .727 40. .548 13. .202 1. .00 58. .84 1SG 356
ATOM 356 O THR 47 149. .717 39, .941 12. .796 1. .00 58. .84 1SG 357
ATOM 357 N ARG 48 147. .829 39, .992 14. .032 1, .00 62 .06 1SG 358
ATOM 358 CA ARG 48 147. .937 38, .603 14. .320 1. .00 62, .06 1SG 359
ATOM 359 CB ARG 48 147. .423 38, .208 15. .711 1. .00 62, .06 1SG 360
ATOM 360 CG ARG 48 148. .318 38, .733 16. .833 1, .00 62 .06 1SG 361
ATOM 361 CD ARG 48 149, .089 37 .641 17, .577 1. .00 62 .06 1SG 362
ATOM 362 NE ARG 48 150, .104 38, .324 18. .430 1. .00 62, .06 1SG 363
ATOM 363 CZ ARG 48 149. .777 38, .821 19. .659 1. .00 62, .06 1SG 364
ATOM 364 NHl ARG 48 148, .501 38, .717 20. .132 1, .00 62, .06 1SG 365
ATOM 365 NH2 ARG 48 150, .736 39 .428 20. .417 1, .00 62 .06 1SG 366
ATOM 366 C ARG 48 147. .050 37, .994 13. .301 1. .00 62 .06 1SG 367
ATOM 367 O ARG 48 145. .930 38, .459 13. .092 1, .00 62, .06 1SG 368
ATOM 368 N ILE 49 147, .532 36 .943 12. .623 1. .00 65, .13 1SG 369
ATOM 369 CA ILE 49 146, .762 36 .405 11. .551 1. .00 65, .13 1SG 370
ATOM 370 CB ILE 49 147. ,541 36. .267 10. .279 1. .00 65. .13 1SG 371
ATOM 371 CG2 ILE 49 148. .445 35. .030 10. .409 1. ,00 65. .13 1SG 372
ATOM 372 CGI ILE 49 146. .594 36. .186 9. .078 1. ,00 65. .13 1SG 373
ATOM 373 CDl ILE 49 147. .310 36. .394 7. .746 1. .00 65. .13 1SG 374
ATOM 374 C ILE 49 146. ,354 35. .042 11. .956 1. .00 65. .13 1SG 375
ATOM 375 0 ILE 49 147. .075 34. .360 12. ,684 1. .00 65. .13 1SG 376
ATOM 376 N ARG 50 145. .147 34. .631 11. .525 1. .00 68. .72 1SG 377
ATOM 377 CA ARG 50 144. .708 33, .339 11. .927 1. .00 68. .72 1SG 378
ATOM 378 CB ARG 50 145. .730 32, .223 11. .631 1. .00 68. .72 1SG 379
ATOM 379 CG ARG 50 146. ,135 32. .120 10. .158 1. ,00 68. .72 1SG 380
ATOM 380 CD ARG 50 147. ,326 31. .187 9. .915 1. ,00 68. .72 1SG 381
ATOM 381 NE ARG 50 146. .969 29. .837 10. .437 1. ,00 68. .72 1SG 382 ATOM 382 CZ ARG 50 147.951 28..983 10,.855 1,.00 68.72 1SG 383
ATOM 383 NHl ARG 50 149 .259 29, .367 10, .805 1. .00 68 .72 1SG 384
ATOM 384 NH2 ARG 50 147 .624 27, .746 11, .329 1, .00 68 .72 1SG 385
ATOM 385 C ARG 50 144 .579 33. .470 13, .396 1. .00 68 .72 1SG 386
ATOM 386 0 ARG 50 144 .503 34. .579 13, .920 1. .00 68 .72 1SG 387
ATOM 387 N ILE 51 144 .462 32. .332 14, .086 1, .00 72 .36 1SG 388
ATOM 388 CA ILE 51 144 .495 32, .327 15, .510 1, .00 72 .36 1SG 389
ATOM 389 CB ILE 51 143 .136 32, .527 16, .134 1. .00 72 .36 1SG 390
ATOM 390 CG2 ILE 51 143 .263 32, .397 17, .660 1. .00 72 .36 1SG 391
ATOM 391 CGI ILE 51 142 .556 33, .889 15, .736 1. .00 72 .36 1SG 392
ATOM 392 CDl ILE 51 143. .331 35, .052 16, .351 1. .00 72 .36 1SG 393
ATOM 393 C ILE 51 145 .093 30. .990 15, .814 1, .00 72 .36 1SG 394
ATOM 394 O ILE 51 145. .275 30. .185 14, .903 1. .00 72 .36 1SG 395
ATOM 395 N LEU 52 145, .443 30. .712 17, .081 1. .00 73, .35 1SG 396
ATOM 396 CA LEU 52 146 .068 29, .457 17, .393 1, .00 73 .35 1SG 397
ATOM 397 CB LEU 52 146, .235 29. .260 18, .906 1. .00 73 .35 1SG 398
ATOM 398 CG LEU 52 146, .977 30. .395 19, .633 1. .00 73 .35 1SG 399
ATOM 399 CD2 LEU 52 147, .379 29. .957 21, .048 1. .00 73 .35 1SG 400
ATOM 400 CDl LEU 52 146, .173 31. .707 19, .622 1. .00 73 .35 1SG 401
ATOM 401 C LEU 52 145, .111 28. .394 16. .968 1. .00 73, .35 1SG 402
ATOM 402 O LEU 52 145, .456 27. .457 16. .250 1. .00 73, .35 1SG 403
ATOM 403 N ASN 53 143, .860 28. .556 17. .418 1. .00 74, .96 1SG 404
ATOM 404 CA ASN 53 142, .734 27. .768 17. .035 1. .00 74. .96 1SG 405
ATOM 405 CB ASN 53 141 .850 27. .341 18 .216 1. .00 74 .96 1SG 406
ATOM 406 CG ASN 53 142 .685 26. .417 19 .087 1. .00 74 .96 1SG 407
ATOM 407 OD1 ASN 53 143 .120 26. .796 20 .173 1. .00 74 .96 1SG 408
ATOM 408 ND2 ASN 53 142 .928 25. .173 18 .594 1. .00 74 .96 1SG 409
ATOM 409 C ASN 53 142 .020 28, .824 16, .303 1, .00 74 .96 1SG 410
ATOM 410 O ASN 53 142 .619 29, .871 16 .100 1, .00 74 .96 1SG 411
ATOM 411 N VAL 54 140 .788 28, .674 15 .823 1. .00 77 .03 1SG 412
ATOM 412 CA VAL 54 140 .437 29, .914 15, .209 1, .00 77 .03 1SG 413
ATOM 413 CB VAL 54 140 .290 29, .849 13, .718 1, .00 77, .03 1SG 414
ATOM 414 CGI VAL 54 141 .661 29, .505 13 .111 1, .00 77, .03 1SG 415
ATOM 415 CG2 VAL 54 139 .178 28, .848 13, .369 1. .00 77, .03 1SG 416
ATOM 416 C VAL 54 139 .169 30, .418 15, .766 1, .00 77, .03 1SG 417
ATOM 417 O VAL 54 138 .234 29, .667 16, .049 1. .00 77, .03 1SG 418
ATOM 418 N HIS 55 139 .147 31, .742 15, .982 1. .00 75, .30 1SG 419
ATOM 419 CA HIS 55 137 .914 32 , .327 16, .360 1, .00 75, .30 1SG 420
ATOM 420 NDl HIS 55 140, .257 33. .773 18, .168 1. .00 75, .30 1SG 421
ATOM 421 CG HIS 55 138, .879 33, .764 18, .161 1. .00 75, .30 1SG 422
ATOM 422 CB HIS 55 138, .053 33. .754 16, .908 1. .00 75, .30 1SG 423
ATOM 423 NE2 HIS 55 139, .611 33. .724 20, .295 1. .00 75, .30 1SG 424
ATOM 424 CD2 HIS 55 138, .502 33. .734 19, .469 1. .00 75, .30 1SG 425
ATOM 425 CE1 HIS 55 140, .642 33. .748 19, .469 1. .00 75. .30 1SG 426
ATOM 426 C HIS 55 137, .167 32. .332 15. .082 1. .00 75. .30 1SG 427
ATOM 427 0 HIS 55 137 .735 32. .645 14. .036 1, .00 75. .30 1SG 428
ATOM 428 N VAL 56 135 .891 31, .924 15. .115 1. .00 72. .65 1SG 429
ATOM 429 CA VAL 56 135 .219 31, .860 13. .861 1. .00 72, .65 1SG 430
ATOM 430 CB VAL 56 134, .554 30, .537 13. .633 1. .00 72, .65 1SG 431
ATOM 431 CGI VAL 56 133 .872 30, .559 12. .256 1. .00 72 , .65 1SG 432
ATOM 432 CG2 VAL 56 135, .599 29, .427 13. .821 1. .00 72 , .65 1SG 433
ATOM 433 C VAL 56 134, .162 32, .903 13 , .914 1. .00 72. .65 1SG 434
ATOM 434 O VAL 56 133, .131 32. .756 14. .563 1. .00 72. .65 1SG 435
ATOM 435 N PRO 57 134, .437 33. .990 13. .272 1. .00 67. .98 1SG 436
ATOM 436 CA PRO 57 133, .450 35. .019 13, .265 1. .00 67. .98 1SG 437
ATOM 437 CD PRO 57 135, .771 34. .545 13. .348 1. .00 67. .98 1SG 438
ATOM 438 CB PRO 57 134. .185 36. ,329 13. .064 1. .00 67. .98 1SG 439 ATOM 439 CG PRO 57 135..626 35..928 12..716 1..00 67..98 1SG 440
ATOM 440 C PRO 57 132 .296 34. .760 12. .354 1. .00 67. .98 1SG 441
ATOM 441 O PRO 57 131 .272 35. .423 12. .510 1. .00 67. .98 1SG 442
ATOM 442 N ARG 58 132 .422 33. .836 11 .382 1, .00 61, .39 1SG 443
ATOM 443 CA ARG 58 131, .279 33. .611 10. .553 1. .00 61. .39 1SG 444
ATOM 444 CB ARG 58 131 .414 34. .194 9. .139 1. .00 61. .39 1SG 445
ATOM 445 CG ARG 58 130 .109 34. .180 8 .340 1. .00 61. .39 1SG 446
ATOM 446 CD ARG 58 129 .021 35. .068 8 .948 1. .00 61, .39 1SG 447
ATOM 447 NE ARG 58 127. .849 35. .034 8. .030 1. .00 61. .39 1SG 448
ATOM 448 CZ ARG 58 126. .597 35. .307 8, .500 1. .00 61. .39 1SG 449
ATOM 449 NHl ARG 58 126. .401 35. .561 9. .828 1. .00 61. .39 1SG 450
ATOM 450 NH2 ARG 58 125 .541 35. .326 7 .638 1 .00 61. .39 1SG 451
ATOM 451 C ARG 58 131 .072 32. .138 10 .439 1. .00 61. .39 1SG 452
ATOM 452 O ARG 58 132 .023 31. .377 10 .280 1, .00 61. .39 1SG 453
ATOM 453 N LEU 59 129 .805 31. .700 10 .577 1. .00 56. .27 1SG 454
ATOM 454 CA LEU 59 129 .444 30. .324 10 .412 1. .00 56. .27 1SG 455
ATOM 455 CB LEU 59 129 .268 29, .518 11 .713 1, .00 56. .27 1SG 456
ATOM 456 CG LEU 59 130 .576 29, .308 12 .499 1. .00 56. .27 1SG 457
ATOM 457 CD2 LEU 59 130, .445 28, .168 13 .522 1. .00 56, .27 1SG 458
ATOM 458 CDl LEU 59 131 .066 30, .623 13 .121 1. .00 56, .27 1SG 459
ATOM 459 C LEU 59 128 .134 30, .337 9 .702 1, .00 56, .27 1SG 460
ATOM 460 O LEU 59 127 .488 31. .380 9 .615 1. .00 56, .27 1SG 461
ATOM 461 N HIS 60 127, .732 29, .183 9, .133 1. .00 51, .66 1SG 462
ATOM 462 CA HIS 60 126, .471 29, .125 8, .456 1. .00 51, .66 1SG 463
ATOM 463 NDl HIS 60 127, .837 31. .011 5, .510 1. .00 51, .66 1SG 464
ATOM 464 CG HIS 60 126, .947 30. .699 6 .515 1. .00 51, .66 1SG 465
ATOM 465 CB HIS 60 126 .578 29 .299 6 .928 1 .00 51 .66 1SG 466
ATOM 466 NE2 HIS 60 127 .090 32 .943 6 .322 1 .00 51, .66 1SG 467
ATOM 467 CD2 HIS 60 126 .500 31, .888 6 .999 1 .00 51 .66 1SG 468
ATOM 468 CE1 HIS 60 127 .883 32, .368 5 .439 1. .00 51, .66 1SG 469
ATOM 469 C HIS 60 125 .856 27, .787 8 .721 1. .00 51, .66 1SG 470
ATOM 470 O HIS 60 126 .557 26, .797 8 .930 1. .00 51, .66 1SG 471
ATOM 471 N LEU 61 124 .508 27, .741 8 .745 1, .00 49, .02 1SG 472
ATOM 472 CA LEU 61 123 .796 26, .511 8 .947 1, .00 49. .02 1SG 473
ATOM 473 CB LEU 61 122 .649 26. .579 9 .972 1, .00 49. .02 1SG 474
ATOM 474 CG LEU 61 122, .959 27. .429 11 .209 1, .00 49, .02 1SG 475
ATOM 475 CD2 LEU 61 122, .009 27. .137 12 .383 1, .00 49. .02 1SG 476
ATOM 476 CDl LEU 61 122, .960 28. .909 10 .793 1, .00 49. .02 1SG 477
ATOM 477 C LEU 61 123, .049 26. .344 7, .673 1, .00 49. .02 1SG 478
ATOM 478 O LEU 61 122, .243 27. .200 7, .311 1, .00 49. .02 1SG 479
ATOM 479 N LYS 62 123, .281 25. .247 6, .943 1. .00 46. .25 1SG 480
ATOM 480 CA LYS 62 122, .526 25. .135 5 .738 1. .00 46. .25 1SG 481
ATOM 481 CB LYS 62 123, .379 25, .183 4 .461 1. .00 46. .25 1SG 482
ATOM 482 CG LYS 62 124, .752 24 , .531 4, .590 1, .00 46, .25 1SG 483
ATOM 483 CD LYS 62 125, .607 24. .742 3 .340 1, .00 46. .25 1SG 484
ATOM 484 CE LYS 62 125, .602 26. .195 2, .845 1. .00 46. .25 1SG 485
ATOM 485 NZ LYS 62 125, .690 27. .139 3, .984 1, .00 46. .25 1SG 486
ATOM 486 C LYS 62 121, .665 23. .925 5. .812 1. .00 46. .25 1SG 487
ATOM 487 O LYS 62 121. .985 22. .944 6, .483 1. .00 46. .25 1SG 488
ATOM 488 N PHE 63 120, .507 24. .004 5. .140 1. .00 42. .04 1SG 489
ATOM 489 CA PHE 63 119, .541 22. .952 5, .179 1. .00 42. .04 1SG 490
ATOM 490 CB PHE 63 118. .089 23. .423 5, .008 1. .00 42. ,04 1SG 491
ATOM 491 CG PHE 63 117. .468 23. .760 6, .312 1. ,00 42. ,04 1SG 492
ATOM 492 CDl PHE 63 117. .617 24. .988 6, .913 1. .00 42. ,04 1SG 493
ATOM 493 CD2 PHE 63 116. .705 22. ,800 6. .937 1. ,00 42. ,04 1SG 494
ATOM 494 CE1 PHE 63 117. ,012 25. ,241 8. .121 1. ,00 42. ,04 1SG 495
ATOM 495 CE2 PHE 63 116. .101 23. .052 8, .140 1. .00 42. .04 1SG 496 r~ oo σι θ H n ι, m vo σ
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ATOM 553 CD2 LEU 71 124,.360 24..433 11..497 1..00 68..12 1SG 554
ATOM 554 CDl LEU 71 125. .088 23, .287 13, .664 1. .00 68. .12 1SG 555
ATOM 555 C LEU 71 128. .552 23. .943 10. .239 1. .00 68. .12 1SG 556
ATOM 556 O LEU 71 129. .317 22. .982 10. .164 1. .00 68. .12 1SG 557
ATOM 557 N LEU 72 128. .966 25. .234 10. .228 1. .00 82, .25 1SG 558
ATOM 558 CA LEU 72 130. .314 25, .665 10, .501 1. .00 82, .25 1SG 559
ATOM 559 CB LEU 72 131. .270 24, .639 11, .133 1. .00 82. .25 1SG 560
ATOM 560 CG LEU 72 131. .035 24 , .498 12. .655 1. .00 82. .25 1SG 561
ATOM 561 CD2 LEU 72 132 .173 23, .725 13. .341 1. .00 82, .25 1SG 562
ATOM 562 CDl LEU 72 129 .638 23, .944 12. .977 1. .00 82, .25 1SG 563
ATOM 563 C LEU 72 130. .976 26, .599 9. .524 1. .00 82, .25 1SG 564
ATOM 564 O LEU 72 130. .363 27. .066 8. .565 1. .00 82, .25 1SG 565
ATOM 565 N ALA 73 132 .240 26. .981 9. .863 1, .00 90, .11 1SG 566
ATOM 566 CA ALA 73 133. .081 27. .899 9, .126 1. .00 90, .11 1SG 567
ATOM 567 CB ALA 73 132. .355 29, .179 8. .687 1. .00 90, .11 1SG 568
ATOM 568 C ALA 73 134, .242 28, .303 10. .020 1. .00 90, .11 1SG 569
ATOM 569 O ALA 73 134 .424 27, .669 11. .059 1, .00 90 .11 1SG 570
ATOM 570 N ALA 74 135 .108 29, .287 9. .600 1, .00 91 .40 1SG 571
ATOM 571 CA ALA 74 136, .143 29, .835 10. .477 1. .00 91, .40 1SG 572
ATOM 572 CB ALA 74 136, .935 28, .754 11. .239 1. .00 91, .40 1SG 573
ATOM 573 C ALA 74 137 .166 30 .730 9 .764 1. .00 91 .40 1SG 574
ATOM 574 O ALA 74 137 .460 30, .513 8, .587 1. .00 91 .40 1SG 575
ATOM 575 N ALA 75 137 .734 31, .766 10, .478 1, .00 85, .19 1SG 576
ATOM 576 CA ALA 75 138, .796 32 , .657 10, .006 1. .00 85, .19 1SG 577
ATOM 577 CB ALA 75 138 .563 33 .201 8 .585 1. .00 85 .19 1SG 578
ATOM 578 C ALA 75 138 .924 33 .865 10, .925 1. .00 85 .19 1SG 579
ATOM 579 O ALA 75 137 .945 34. .249 11, .568 1, .00 85, .19 1SG 580
ATOM 580 N ASN 76 140, .117 34. .519 11, .017 1. .00 75, .14 1SG 581
ATOM 581 CA ASN 76 140 .207 35 .665 11 .897 1. .00 75 .14 1SG 582
ATOM 582 CB ASN 76 140 .165 35. .222 13 .376 1, .00 75 .14 1SG 583
ATOM 583 CG ASN 76 139 .727 36. .381 14, .259 1. .00 75, .14 1SG 584
ATOM 584 OD1 ASN 76 138 .550 36. .467 14, .603 1, .00 75, .14 1SG 585
ATOM 585 ND2 ASN 76 140 .670 37 .283 14 .638 1 .00 75 .14 1SG 586
ATOM 586 C ASN 76 141 .503 36. .429 11 .668 1. .00 75 .14 1SG 587
ATOM 587 O ASN 76 142 .559 35, .826 11, .478 1. .00 75 .14 1SG 588
ATOM 588 N PHE 77 141, .442 37, .789 11, .683 1, .00 65 .67 1SG 589
ATOM 589 CA PHE 77 142, .612 38. .637 11. .584 1. .00 65, .67 1SG 590
ATOM 590 CB PHE 77 142 .672 39 .646 10 .408 1. .00 65 .67 1SG 591
ATOM 591 CG PHE 77 142 .537 39. .097 9, .030 1. .00 65 .67 1SG 592
ATOM 592 CDl PHE 77 143, .578 38. .447 8, .401 1, .00 65, .67 1SG 593
ATOM 593 CD2 PHE 77 141, .350 39, .259 8, .347 1, .00 65, .67 1SG 594
ATOM 594 CE1 PHE 77 143 .436 37, .967 7 .124 1. .00 65 .67 1SG 595
ATOM 595 CE2 PHE 77 141, .205 38, .781 7, .068 1, .00 65 .67 1SG 596
ATOM 596 CZ PHE 77 142, .249 38. .132 6, .450 1. .00 65, .67 1SG 597
ATOM 597 C PHE 77 142, .492 39. .594 12, .739 1. .00 65, .67 1SG 598
ATOM 598 O PHE 77 141, .391 39, .860 13, .214 1. .00 65 .67 1SG 599
ATOM 599 N THR 78 143, .614 40, .136 13, .251 1, .00 56, .37 1SG 600
ATOM 600 CA THR 78 143, .419 41. .114 14, .281 1. .00 56, .37 1SG 601
ATOM 601 CB THR 78 143 , .588 40. .563 15, .672 1. .00 56, .37 1SG 602
ATOM 602 OGl THR 78 143, .248 41. .552 16, .629 1. .00 56, .37 1SG 603
ATOM 603 CG2 THR 78 145, .029 40. .069 15, .872 1, .00 56, .37 1SG 604
ATOM 604 C THR 78 144, .378 42. .244 14, .076 1. .00 56, .37 1SG 605
ATOM 605 O THR 78 145. .581 42. .033 13. .920 1. .00 56, .37 1SG 606
ATOM 606 N PHE 79 143, .870 43. .491 14. .028 1, .00 51, .00 1SG 607
ATOM 607 CA PHE 79 144, .829 44. .549 13. .958 1. .00 51, .00 1SG 608
ATOM 608 CB PHE 79 144. .853 45. .363 12. .642 1. .00 51. .00 1SG 609
ATOM 609 CG PHE 79 143. .809 46. .427 12. .553 1. .00 51. .00 1SG 610 ATOM 610 CDl PHE 79 142..464 46..144 12.,466 1.,00 51.,00 1SG 611
ATOM 611 CD2 PHE 79 144, .220 47, .740 12. .502 1. .00 51. .00 1SG 612
ATOM 612 CE1 PHE 79 141, .556 47, .175 12. .365 1. .00 51. .00 1SG 613
ATOM 613 CE2 PHE 79 143. .321 48, .772 12. .397 1. .00 51. .00 1SG 614
ATOM 614 CZ PHE 79 141. .982 48, .484 12. .335 1. .00 51. .00 1SG 615
ATOM 615 C PHE 79 144. .490 45. .458 15. .080 1. ,00 51. .00 1SG 616
ATOM 616 O PHE 79 143, .350 45. .892 15. .226 1. .00 51, .00 1SG 617
ATOM 617 N LYS 80 145, .493 45. .759 15. .919 1. .00 47. .87 1SG 618
ATOM 618 CA LYS 80 145, .292 46. .590 17. .063 1. .00 47. .87 1SG 619
ATOM 619 CB LYS 80 145, .201 48, .098 16. .800 1. ,00 47. .87 1SG 620
ATOM 620 CG LYS 80 145, .368 48, .830 18. .130 1. ,00 47. .87 1SG 621
ATOM 621 CD LYS 80 145, .739 50 .302 18. .025 1. .00 47. .87 1SG 622
ATOM 622 CE LYS 80 146, .634 50, .731 19. .186 1. .00 47. .87 1SG 623
ATOM 623 NZ LYS 80 146, .816 52, .196 19. .181 1. .00 47, .87 1SG 624
ATOM 624 C LYS 80 144 , .091 46, .150 17. .849 1. .00 47. .87 1SG 625
ATOM 625 O LYS 80 144 , .022 45, .008 18. ,297 1. .00 47. .87 1SG 626
ATOM 626 N VAL 81 143 .110 47 .056 18, .034 1, .00 47 .32 1SG 627
ATOM 627 CA VAL 81 141, .991 46, .837 18 , .912 1. .00 47, .32 1SG 628
ATOM 628 CB VAL 81 141, .029 47, .987 18. .906 1. .00 47, .32 1SG 629
ATOM 629 CGI VAL 81 139, .863 47, .685 19. .864 1. .00 47, .32 1SG 630
ATOM 630 CG2 VAL 81 141, .813 49, .257 19. .256 1. .00 47, .32 1SG 631
ATOM 631 C VAL "81 141 .180 45 .640 18. .550 1. .00 47 .32 1SG 632
ATOM 632 O VAL 81 140 .857 44 .821 19. .409 1. .00 47 .32 1SG 633
ATOM 633 N PHE 82 140 .822 45, .452 17. .275 1. .00 50, .50 1SG 634
ATOM 634 CA PHE 82 139, .883 44, .385 17. .224 1. .00 50, .50 1SG 635
ATOM 635 CB PHE 82 138, .437 44, .894 17, .120 1. .00 50, .50 1SG 636
ATOM 636 CG PHE 82 137 .632 44 .147 18, .132 1. .00 50 .50 1SG 637
ATOM 637 CDl PHE 82 137 .015 42 .946 17, .852 1. .00 50 .50 1SG 638
ATOM 638 CD2 PHE 82 137 .508 44 .670 19, .401 1. .00 50 .50 1SG 639
ATOM 639 CE1 PHE 82 136, .285 42, .295 18, .824 1. .00 50, .50 1SG 640
ATOM 640 CE2 PHE 82 136, .783 44, .027 20. .372 1. .00 50, .50 1SG 641
ATOM 641 CZ PHE 82 136 .169 42 .833 20. .084 1, .00 50 .50 1SG 642
ATOM 642 C PHE 82 140 .185 43 .485 16, .083 1, .00 50 .50 1SG 643
ATOM 643 O PHE 82 141 .151 43 .675 15, .344 1, .00 50 .50 1SG 644
ATOM 644 N ARG 83 139, .344 42 .448 15, .944 1, .00 52 .60 1SG 645
ATOM 645 CA ARG 83 139, .561 41, .459 14, .939 1. .00 52 .60 1SG 646
ATOM 646 CB ARG 83 139 .127 40 .047 15, .360 1, .00 52 .60 1SG 647
ATOM 647 CG ARG 83 139 .355 39 .670 16, .825 1, .00 52 .60 1SG 648
ATOM 648 CD ARG 83 138, .305 40 .288 17, .750 1, .00 52 .60 1SG 649
ATOM 649 NE ARG 83 138, .350 39 .585 19. .063 1. .00 52 .60 1SG 650
ATOM 650 CZ ARG 83 137, .457 38, .587 19. .337 1. .00 52, .60 1SG 651
ATOM 651 NHl ARG 83 136 .585 38 .156 18. .384 1, .00 52 .60 1SG 652
ATOM 652 NH2 ARG 83 137 .420 38 .040 20. .591 1. .00 52 .60 1SG 653
ATOM 653 C ARG 83 138, .653 41 .757 13. .790 1. .00 52, .60 1SG 654
ATOM 654 O ARG 83 137, .520 42, .198 13. .986 1. .00 52, .60 1SG 655
ATOM 655 N ALA 84 139, .160 41, .510 12. .560 1. .00 56. .27 1SG 656
ATOM 656 CA ALA 84 138 .405 41 .622 11, .346 1. .00 56 .27 1SG 657
ATOM 657 CB ALA 84 139 .202 42 .222 10, .178 1, .00 56, .27 1SG 658
ATOM 658 C ALA 84 138, .064 40, .223 10, .970 1. .00 56, .27 1SG 659
ATOM 659 O ALA 84 138, .920 39, .361 10. .770 1. .00 56, .27 1SG 660
ATOM 660 N PRO 85 136, .787 40, .019 10. .923 1. ,00 61, .83 1SG 661
ATOM 661 CA PRO 85 136 .232 38 .736 10, .602 1. .00 61, .83 1SG 662
ATOM 662 CD PRO 85 135 .905 40, .802 11. .775 1. .00 61, .83 lsσ 663
ATOM 663 CB PRO 85 134, .851 38, .722 11. .246 1. .00 61, .83 1SG 664
ATOM 664 CG PRO 85 134, .522 40, .187 11. .554 1. .00 61, .83 1SG 665
ATOM 665 C PRO 85 136. .130 38, .428 9. .145 1. .00 61. .83 1SG 666
ATOM 666 O PRO 85 136. .067 39., .341 8. .325 1. .00 61. .83 1SG 667 ATOM 667 N GLU 86 136..117 37..126 8..807 1..00 66,.60 1SG 668
ATOM 668 CA GLU 86 135. .827 36. .723 7. .467 1. .00 66, .60 1SG 669
ATOM 669 CB GLU 86 136. .929 36. .953 6. .419 1. .00 66. .60 1SG 670
ATOM 670 CG GLU 86 137, .044 38, .388 5. .918 1. .00 66 .60 1SG 671
ATOM 671 CD GLU 86 137, .799 38, .324 4. .598 1. .00 66, .60 1SG 672
ATOM 672 OEl GLU 86 138. .472 37. .289 4. .347 1. .00 66, .60 1SG 673
ATOM 673 OE2 GLU 86 137. .697 39. .304 3. .815 1. .00 66. .60 1SG 674
ATOM 674 C GLU 86 135, .614 35. .255 7, .489 1. .00 66 .60 1SG 675
ATOM 675 O GLU 86 136, .158 34, .518 8. .308 1. .00 66 .60 1SG 676
ATOM 676 N PRO 87 134. .756 34 , .852 6, .611 1. .00 76. .20 1SG 677
ATOM 677 CA PRO 87 134. .531 33. .449 6. .421 1. .00 76. .20 1SG 678
ATOM 678 CD PRO 87 133, .553 35. .639 6, .400 1. .00 76 .20 1SG 679
ATOM 679 CB PRO 87 133, .109 33, .318 5, .883 1. .00 76 .20 1SG 680
ATOM 680 CG PRO 87 132. .414 34. .620 6, .315 1, .00 76 .20 1SG 681
ATOM 681 C PRO 87 135. .552 33. .062 5, .404 1. .00 76. .20 1SG 682
ATOM 682 O PRO 87 136, .221 33, .963 4, .902 1 .00 76 .20 1SG 683
ATOM 683 N LEU 88 135, .708 31, .750 5, .124 1. .00 83 .34 1SG 684
ATOM 684 CA LEU 88 136. .533 31, .217 4, .071 1, .00 83 .34 1SG 685
ATOM 685 CB LEU 88 137. .049 32. .198 2. .992 1. .00 83 .34 1SG 686
ATOM 686 CG LEU 88 135, .952 32 .597 1 .969 1 .00 83 .34 1SG 687
ATOM 687 CD2 LEU 88 136. .547 33, .200 0 .689 1 .00 83 .34 1SG 688
ATOM 688 CDl LEU 88 134, .854 33, .482 2, .578 1, .00 83 .34 1SG 689
ATOM 689 C LEU 88 137. .622 30, .363 4, .611 1, .00 83 .34 1SG 690
ATOM 690 O LEU 88 137, .791 30 .247 5 .824 1 .00 83 .34 1SG 691
ATOM 691 N GLU 89 138, .346 29, .679 3 .701 1, .00 88 .23 1SG 692
ATOM 692 CA GLU 89 139, .401 28, .809 4. .127 1. .00 88 .23 1SG 693
ATOM 693 CB GLU 89 139, .833 27, .784 3, .067 1, .00 88 .23 1SG 694
ATOM 694 CG GLU 89 138. .735 26. .768 2, .751 1, .00 88 .23 1SG 695
ATOM 695 CD GLU 89 139. .293 25. .764 1 .756 1, .00 88 .23 ISG'696
ATOM 696 OEl GLU 89 140, .206 24, .990 2 .149 1, .00 88 .23 1SG 697
ATOM 697 OE2 GLU 89 138. .816 25, .756 0, .590 1, .00 88 .23 1SG 698
ATOM 698 C GLU 89 140. .577 29. .663 4, .457 1, .00 88 .23 1SG 699
ATOM 699 O GLU 89 140, .870 30. .616 3 .740 1, .00 88 .23 1SG 700
ATOM 700 N LEU 90 141. .281 29. .320 5, .555 1, .00 94 .01 1SG 701
ATOM 701 CA LEU 90 142. .384 30. .081 6, .071 1, .00 94 .01 1SG 702
ATOM 702 CB LEU 90 142. .519 29. .932 7. .595 1, .00 94 .01 1SG 703
ATOM 703 CG LEU 90 143. .678 30. .718 8 .228 1, .00 94 .01 1SG 704
ATOM 704 CD2 LEU 90 143. .898 30. .269 9, .678 1, .00 94 .01 1SG 705
ATOM 705 CDl LEU 90 143. .480 32. .238 8, .088 1, .00 94 .01 1SG 706
ATOM 706 C LEU 90 143. .635 29, .584 5, .434 1, .00 94 .01 1SG 707
ATOM 707 O LEU 90 143. .603 28, .581 4, .724 1, .00 94 .01 1SG 708
ATOM 708 N THR 91 144, .769 30, .288 5, .662 1, .00 91 .26 1SG 709
ATOM 709 CA THR 91 146. .014 29, .856 5, .099 1, .00 91 .26 1SG 710
ATOM 710 CB THR 91 147. .187 30. .663 5. .539 1, .00 91, .26 1SG 711
ATOM 711 OGl THR 91 147. .005 32. .030 5, .200 1, .00 91 .26 1SG 712
ATOM 712 CG2 THR 91 148. .428 30. .108 4 , .823 1, .00 91 .26 1SG 713
ATOM 713 C THR 91 146. .172 28. .479 5. .615 1, .00 91 .26 1SG 714
ATOM 714 O THR 91 146. .527 27. .561 4. .878 1. .00 91, .26 1SG 715
ATOM 715 N LEU 92 145. .907 28, .313 6, .920 1 .00 88 .64 1SG 716
ATOM 716 CA LEU 92 145. .705 26, .976 7, .358 1, .00 88 .64 1SG 717
ATOM 717 CB LEU 92 146. .114 26. .708 8 , .819 1, .00 88, .64 1SG 718
ATOM 718 CG LEU 92 146. .067 25. .222 9. .250 1, .00 88, .64 1SG 719
ATOM 719 CD2 LEU 92 144. .734 24. .532 8. .912 1, .00 88 .64 1SG 720
ATOM 720 CDl LEU 92 146. .434 25. .079 10. .734 1, .00 88 .64 1SG 721
ATOM 721 C LEU 92 144. .216 26. .926 7. .288 1. .00 88, .64 1SG 722
ATOM 722 O LEU 92 143. .521 27. .366 8. .205 1. .00 88, .64 1SG 723
ATOM 723 N PRO 93 143. .722 26. .416 6. .194 1, .00 82 .92 1SG 724 H oo r~ - O . CI . - t5 0 0 Cl U U O U . ) 0 - U ϋ - . . O O . O O . . O U U O . - . O . O U O O O C) C) 0 (5 (5 -3 w cΛ w w -3 w w w iΛ -2 w w ιn w w -5 w ω cn ϊΛ cf) cn cn w w cΛ -j co ω w H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H
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Figure imgf000235_0005
ATOM 781 O THR 100 121.,311 17.,791 11.,567 1.00 38.52 1SG 782
ATOM 782 N ARG 101 121. ,585 16. .203 13. ,154 1. ,00 37. ,98 1SG 783
ATOM 783 CA ARG 101 120. .397 15. .512 12. ,765 1. 00 37. 98 1SG 784
ATOM 784 CB ARG 101 120. .574 13. .986 12. ,684 1. ,00 37. ,98 1SG 785
ATOM 785 CG ARG 101 119. .391 13. .263 12. .039 1. .00 37. ,98 1SG 786
ATOM 786 CD ARG 101 119. .559 11. .743 11. .992 1. .00 37. 98 1SG 787
ATOM 787 NE ARG 101 120. ,806 11. ,454 11. .230 1. 00 37. 98 1SG 788
ATOM 788 CZ ARG 101 121. .304 10, .183 11. .199 1. .00 37. ,98 1SG 789
ATOM 789 NHl ARG 101 120. .640 9, .175 11. .836 1. ,00 37. ,98 1SG 790
ATOM 790 NH2 ARG 101 122. .467 9. .921 10. ,535 1. ,00 37. 98 1SG 791
ATOM 791 C ARG 101 119. .374 15. .795 13. .808 1. . 00 37. ,98 1SG 792
ATOM 792 O ARG 101 119. .668 15. ,790 15. .003 1. .00 37. ,98 1SG 793
ATOM 793 N VAL 102 118. .133 16, .072 13. .372 1. ,00 37. ,52 1SG 794
ATOM 794 CA VAL 102 117. .104 16, .373 14. .318 1. .00 37. ,52 1SG 795
ATOM 795 CB VAL 102 116. .327 17. .611 13. . 919 1. .00 37. ,52 1SG 796
ATOM 796 CGI VAL 102 115. .614 17, .385 12. .635 1, ,00 37. .52 1SG 797
ATOM 797 CG2 VAL 102 115. .368 17, .917 15. .142 1. .00 37. .52 1SG 798
ATOM 798 C VAL 102 116. .139 15. .239 14. .323 1. .00 37. .52 1SG 799
ATOM 799 O VAL 102 115, .781 14, .702 13 , .277 1. .00 37. .52 1SG 800
ATOM 800 N THR 103 115. .709 14, .823 15. .526 1. .00 36. .90 1SG 801
ATOM 801 CA THR 103 114. .734 13, .782 15. .608 1. .00 36. .90 1SG 802
ATOM 802 CB THR 103 115. .305 12 .395 15. .738 1, .00 36, .90 1SG 803
ATOM 803 OGl THR 103 114. .266 11, .429 15. .671 1. .00 36, .90 1SG 804
ATOM 804 CG2 THR 103 116. .075 12, .264 17. .055 1. .00 36. .90 1SG 805
ATOM 805 C THR 103 113 .864 14 .096 16 .776 1. .00 36. .90 1SG 806
ATOM 806 O THR 103 114. .026 15 .130 17. .423 1. .00 36, .90 1SG 807
ATOM 807 N GLN 104 112. .878 13, .230 17. .058 1. .00 37. .22 1SG 808
ATOM 808 CA GLN 104 112, .009 13, .520 18. .156 1. .00 37. .22 1SG 809
ATOM 809 CB GLN 104 110 .539 13 .727 17 .754 1, .00 37. .22 1SG 810
ATOM 810 CG GLN 104 110, .286 15, .047 17. .028 1. .00 37. .22 1SG 811
ATOM 811 CD GLN 104 110, .381 16 .162 18. .062 1, .00 37. .22 1SG 812
ATOM 812 OEl GLN 104 110, .414 15, . 906 19. .265 1, .00 37. .22 1SG 813
ATOM 813 NE2 GLN 104 110. .423 17 .434 17. .584 1, .00 37. .22 1SG 814
ATOM 814 C GLN 104 112 .038 12 .369 19 .089 1 .00 37 .22 1SG 815
ATOM 815 O GLN 104 112. .301 11 .231 18, .700 1, .00 37, .22 1SG 816
ATOM 816 N SER 105 111. .776 12 .658 20 .372 1 .00 41, .37 1SG 817
ATOM 817 CA SER 105 Ill, .703 11 .604 21, .324 1 .00 41 .37 1SG 818
ATOM 818 CB SER 105 112, .401 11 .913 22 .658 1 .00 41, .37 1SG 819
ATOM 819 OG SER 105 112 .275 10 .808 23 .540 1 .00 41, .37 1SG 820
ATOM 820 C SER 105 110, .251 11 .462 21, .597 1, .00 41, .37 1SG 821
ATOM 821 O SER 105 109, .529 12, .450 21, .724 1. .00 41, .37 1SG 822
ATOM 822 N SER 106 109 .777 10 .214 21 .702 1 .00 46 .91 1SG 823
ATOM 823 CA SER 106 108 .385 10 .005 21 .934 1, .00 46, .91 1SG 824
ATOM 824 CB SER 106 108, .005 8, .517 22, .009 1, .00 46. .91 1SG 825
ATOM 825 OG SER 106 108, .227 7 .895 20, .752 1, .00 46. .91 1SG 826
ATOM 826 C SER 106 108, .078 10 .625 23 .253 1 .00 46, .91 1SG 827
ATOM 827 O SER 106 106, .924 10 .935 23, .541 1, .00 46, .91 1SG 828
ATOM 828 N ILE 107 109 .109 10 .841 24 .095 1, .00 52, .57 1SG 829
ATOM 829 CA ILE 107 108, .807 11, .453 25, .348 1, .00 52. .57 1SG 830
ATOM 830 CB ILE 107 109 .859 11 .193 26 .390 1, .00 52, .57 1SG 831
ATOM 831 CG2 ILE 107 111 .189 11 .798 25 .907 1 .00 52, .57 1SG 832
ATOM 832 CGI ILE 107 109, .393 11 .692 27 .767 1, .00 52, .57 1SG 833
ATOM 833 CDl ILE 107 110 .260 11 .191 28 .920 1 . 00 52, .57 1SG 834
ATOM 834 C ILE 107 108, .711 12. .942 25, .124 1, .00 52 .57 1SG 835
ATOM 835 O ILE 107 109, .246 13 .732 25 .901 1, .00 52, .57 1SG 836
ATOM 836 N ARG 108 107 .978 13 .332 24 .049 1 .00 54, .96 1SG 837
ATOM 837 CA ARG 108 107, .545 14. .659 23 .679 1. .00 54, .96 1SG 838 ATOM 838 CB ARG 108 106,.664 15..264 24..791 1..00 54..96 1SG 839
ATOM 839 CG ARG 108 106. .137 16. .676 24. .525 1. .00 54. .96 1SG 840
ATOM 840 CD ARG 108 105. .275 17. .220 25. .663 1. ,00 54. .96 1SG 841
ATOM 841 NE ARG 108 106 .142 17, .306 26, .870 1. .00 54. .96 1SG 842
ATOM 842 CZ ARG 108 105, .576 17. .439 28, .104 1. .00 54. .96 1SG 843
ATOM 843 NHl ARG 108 104, .218 17. .486 28, .226 1. .00 54. .96 1SG 844
ATOM 844 NH2 ARG 108 106, .366 17. .518 29. .214 1. .00 54. .96 1SG 845
ATOM 845 C ARG 108 108 .651 15, .636 23. .387 1. .00 54, .96 1SG 846
ATOM 846 O ARG 108 108 .367 16. .750 22, .946 1. .00 54. .96 1SG 847
ATOM 847 N THR 109 109, .938 15. .272 23, .540 1. .00 50. .48 1SG 848
ATOM 848 CA THR 109 110, .912 16. .315 23. .354 1. .00 50. .48 1SG 849
ATOM 849 CB THR 109 111 .890 16. .435 24. .486 1. .00 50, .48 1SG 850
ATOM 850 OGl THR 109 111 .203 16. .691 25. .702 1. .00 50, .48 1SG 851
ATOM 851 CG2 THR 109 112, .860 17. .588 24. .176 1. .00 50, .48 1SG 852
ATOM 852 C THR 109 111, .705 16. .067 22. .112 1. .00 50, .48 1SG 853
ATOM 853 O THR 109 111 .893 14, .935 21. .670 1. .00 50, .48 1SG 854
ATOM 854 N PRO 110 112 .129 17, .155 21. .522 1. .00 44, .69 1SG 855
ATOM 855 CA PRO 110 112 .942 17. .091 20. .337 1. .00 44, .69 1SG 856
ATOM 856 CD PRO 110 111. .360 18. .387 21. .586 1. .00 44, .69 1SG 857
ATOM 857 CB PRO 110 112 .757 18, .430 19. .616 1, .00 44, .69 1SG 858
ATOM 858 CG PRO 110 112 .119 19, .355 20, .668 1, .00 44 .69 1SG 859
ATOM 859 C PRO 110 114 .360 16, .806 20, .703 1. .00 44, .69 1SG 860
ATOM 860 O PRO 110 114. .746 17. .079 21, .838 1. .00 44, .69 1SG 861
ATOM 861 N VAL 111 115 .161 16. .247 19, .776 1, .00 39 .53 1SG 862
ATOM 862 CA VAL 111 116 .529 16. .028 20, .136 1. .00 39, .53 1SG 863
ATOM 863 CB VAL 111 116 .813 14 , .662 20, .691 1. .00 39, .53 1SG 864
ATOM 864 CGI VAL 111 116. .045 14. .505 22. .014 1. .00 39, .53 1SG 865
ATOM 865 CG2 VAL 111 116, .442 13, .613 19. .640 1, .00 39 .53 1SG 866
ATOM 866 C VAL 111 117 .387 16, .250 18. .936 1, .00 39 .53 1SG 867
ATOM 867 O VAL 111 116 .929 16 , .162 17. .798 1. .00 39, .53 1SG 868
ATOM 868 N VAL 112 118 .669 16. .582 19. .182 1. .00 35, .66 1SG 869
ATOM 869 CA VAL 112 119, .599 16. .821 18. .120 1. .00 35, .66 1SG 870
ATOM 870 CB VAL 112 119 .903 18. .277 17. .920 1. .00 35, .66 1SG 871
ATOM 871 CGI VAL 112 120 .986 18. .410 16, .837 1, .00 35, .66 1SG 872
ATOM 872 CG2 VAL 112 118, .592 19. .012 17, .591 1. .00 35. .66 1SG 873
ATOM 873 C VAL 112 120, .883 16. .155 18. .498 1. .00 35. .66 1SG 874
ATOM 874 O VAL 112 121 .230 16. .070 19. .675 1, .00 35. .66 1SG 875
ATOM 875 N SER 113 121 .625 15, .653 17. .493 1, .00 35. .73 1SG 876
ATOM 876 CA SER 113 122, .874 15, .008 17. .769 1. .00 35. .73 1SG 877
ATOM 877 CB SER 113 122, .768 13. .476 17. .859 1. .00 35. .73 1SG 878
ATOM 878 OG SER 113 122 .342 12. .940 16. .615 1. .00 35, .73 1SG 879
ATOM 879 C SER 113 123 .800 15. .333 16, .643 1, .00 35, .73 1SG 880
ATOM 880 O SER 113 123, .377 15. .857 15, .614 1. .00 35. .73 1SG 881
ATOM 881 N ILE 114 125, .104 15. .040 16. .821 1. .00 40. .43 1SG 882
ATOM 882 CA ILE 114 126 .051 15. .324 15, .784 1. .00 40, .43 1SG 883
ATOM 883 CB ILE 114 127. .299 16. .002 16, .313 1. .00 40. .43 1SG 884
ATOM 884 CG2 ILE 114 127, .955 15. .094 17. .367 1. .00 40. .43 1SG 885
ATOM 885 CGI ILE 114 128, .238 16. .466 15. .183 1. ,00 40. .43 1SG 886
ATOM 886 CDl ILE 114 128 .912 15. .341 14. .399 1. .00 40. .43 1SG 887
ATOM 887 C ILE 114 126, .382 14. .026 15, .114 1. .00 40, .43 1SG 888
ATOM 888 O ILE 114 127, .029 13. .148 15. .684 1. .00 40. .43 1SG 889
ATOM 889 N SER 115 125, .888 13. .869 13. .870 1. .00 43. ,12 1SG 890
ATOM 890 CA SER 115 126, .095 12. .675 13. .104 1. .00 43. .12 1SG 891
ATOM 891 CB SER 115 125, .287 12. .661 11. .797 1. .00 43. .12 1SG 892
ATOM 892 OG SER 115 123, .898 12. .709 12. .078 1. ,00 43. .12 1SG 893
ATOM 893 C SER 115 127, .529 12. .566 12. .711 1. ,00 43. .12 1SG 894
ATOM 894 O SER 115 128, .186 11. .563 12, .991 1. .00 43. .12 1SG 895 ATOM 895 N ALA 116 128,.054 13,.612 12,.043 1,.00 49,.07 1SG 896
ATOM 896 CA ALA 116 129, .400 13, .532 11, .565 1. .00 49, .07 1SG 897
ATOM 897 CB ALA 116 129, .494 13, .153 10, .078 1, .00 49, .07 1SG 898
ATOM 898 C ALA 116 130, .045 14, .867 11, .716 1. .00 49, .07 1SG 899
ATOM 899 O ALA 116 129, .381 15, .903 11, .752 1, .00 49, .07 1SG 900
ATOM 900 N CYS 117 131, .386 14, .856 11, .822 1. .00 58, .34 1SG 901
ATOM 901 CA CYS 117 132, .141 16, .060 11, .972 1. .00 58, .34 1SG 902
ATOM 902 CB CYS 117 132, .774 16, .203 13 , .364 1. .00 58, .34 1SG 903
ATOM 903 SG CYS 117 134, .014 14, .893 13, .576 1. .00 58, .34 1SG 904
ATOM 904 C CYS 117 133, .305 15, .926 11, .056 1. .00 58, .34 1SG 905
ATOM 905 O CYS 117 133, .777 14, .825 10, .775 1. .00 58, .34 1SG 906
ATOM 906 N SER 118 133, .798 17, .056 10, .535 1. .00 63, .94 1SG 907
ATOM 907 CA SER 118 134. .986 16, .918 9, .769 1. .00 63, .94 1SG 908
ATOM 908 CB SER 118 134, .770 16, .374 8, .347 1. .00 63, .94 1SG 909
ATOM 909 OG SER 118 134 , .064 17, .320 7, .559 1. .00 63, .94 1SG 910
ATOM 910 C SER 118 135, .585 18, .266 9, .651 1. .00 63. .94 1SG 911
ATOM 911 O SER 118 134. .919 19. .237 9, .295 1. .00 63. .94 1SG 912
ATOM 912 N LEU 119 136. .882 18. .347 9, .965 1. .00 71, .39 1SG 913
ATOM 913 CA LEU 119 137. .588 19. .561 9, .771 1. .00 71, .39 1SG 914
ATOM 914 CB LEU 119 138. .513 19. .912 10, .952 1. .00 71, .39 1SG 915
ATOM 915 CG LEU 119 139. .264 21. .252 10, .811 1. .00 71, .39 1SG 916
ATOM 916 CD2 LEU 119 138. .282 22. .431 10, .730 1. .00 71, .39 1SG 917
ATOM 917 CDl LEU 119 140. .277 21. .230 9. .655 1. .00 71, .39 1SG 918
ATOM 918 C LEU 119 138 .425 19. .196 8 .601 1. .00 71 .39 1SG 919
ATOM 919 O LEU 119 138. .910 18 .070 8 .529 1. .00 71 .39 1SG 920
ATOM 920 N PHE 120 138. .575 20, .074 7, .600 1. .00 74 .57 1SG 921
ATOM 921 CA PHE 120 139. .424 19, .569 6, .571 1. .00 74 .57 1SG 922
ATOM 922 CB PHE 120 138, .697 19, .111 5, .292 1. .00 74 .57 1SG 923
ATOM 923 CG PHE 120 138, .060 20, .274 4 , .620 1. .00 74 .57 1SG 924
ATOM 924 CDl PHE 120 136, .849 20, .761 5, .053 1. .00 74, .57 1SG 925
ATOM 925 CD2 PHE 120 138, .673 20, .864 3, .539 1. .00 74, .57 1SG 926
ATOM 926 CE1 PHE 120 136, .263 21, .832 4 , .421 1. .00 74, .57 1SG 927
ATOM 927 CE2 PHE 120 138, .093 21, .934 2, .903 1, .00 74, .57 1SG 928
ATOM 928 CZ PHE 120 136, .887 22, .419 3, .346 1. .00 74, .57 1SG 929
ATOM 929 C PHE 120 140, .422 20, .610 6, .226 1. .00 74, .57 1SG 930
ATOM 930 O PHE 120 140. .080 21, .712 5. .800 1. .00 74, .57 1SG 931
ATOM 931 N SER 121 141. .701 20. .267 6. .457 1. .00 71, .83 1SG 932
ATOM 932 CA SER 121 142. .790 21. .134 6, .154 1. .00 71. .83 1SG 933
ATOM 933 CB SER 121 144. .111 20. .680 6. .800 1. .00 71. .83 1SG 934
ATOM 934 OG SER 121 145. .155 21. .580 6. .459 1. .00 71. .83 1SG 935
ATOM 935 C SER 121 142. .998 21. .133 4 , .678 1. .00 71. .83 1SG 936
ATOM 936 O SER 121 143. .250 22. .176 4. .081 1. .00 71. .83 1SG 937
ATOM 937 N GLY 122 142. .884 19. .949 4. .045 1. ,00 65. .09 1SG 938
ATOM 938 CA GLY 122 143. .168 19. .871 2. .649 1. ,00 65. .09 1SG 939
ATOM 939 C GLY 122 144. ,629 20. .147 2. .549 1. .00 65. .09 1SG 940
ATOM 940 O GLY 122 145. .428 19. .595 3. .303 1. .00 65. .09 1SG 941
ATOM 941 N HIS 123 145. .020 21, .018 1. .606 1. .00 57. .48 1SG 942
ATOM 942 CA HIS 123 146. .399 21, .389 1, .516 1. .00 57. .48 1SG 943
ATOM 943 NDl HIS 123 149. .447 20, .563 0. .381 1. .00 57. .48 1SG 944
ATOM 944 CG HIS 123 148. .477 21. .490 0. .070 1. .00 57, .48 1SG 945
ATOM 945 CB HIS 123 147. .003 21. .211 0. .113 1. .00 57, .48 1SG 946
ATOM 946 NE2 HIS 123 150. .512 22. .439 -0. .159 1. .00 57. .48 1SG 947
ATOM 947 CD2 HIS 123 149. .145 22. .630 -0. .258 1. .00 57. .48 1SG 948
ATOM 948 CE1 HIS 123 150. .644 21. .183 0. .228 1. .00 57. .48 1SG 949
ATOM 949 C HIS 123 146. .400 22. .843 1. .827 1. .00 57. .48 1SG 950
ATOM 950 O HIS 123 145. ,337 23. ,459 1. .883 1. .00 57. ,48 1SG 951
ATOM 951 N ALA 124 147. ,576 23. ,451 2. .067 1. .00 51. ,86 1SG 952 ATOM 952 CA ALA 124 147..475 24..854 2..330 1..00 51..86 1SG 953
ATOM 953 CB ALA 124 148. .647 25, .399 3, .162 1. .00 51. .86 1SG 954
ATOM 954 C ALA 124 147 .539 25, .527 0 .997 1. .00 51. .86 1SG 955
ATOM 955 O ALA 124 147. .831 26 .717 0 .895 1. .00 51. .86 1SG 956
ATOM 956 N ASN 125 147. .229 24, .759 -0 .062 1, .00 51. .59 1SG 957
ATOM 957 CA ASN 125 147. .144 25, .252 -1, .401 1. .00 51. .59 1SG 958
ATOM 958 CB ASN 125 147. .061 24, .134 -2 .454 1. .00 51. .59 1SG 959
ATOM 959 CG ASN 125 147. .026 24, .787 -3, .829 1. .00 51. .59 1SG 960
ATOM 960 OD1 ASN 125 148. .002 25, .394 -4, .268 1. .00 51. .59 1SG 961
ATOM 961 ND2 ASN 125 145, .871 24 , .658 -4, .535 1. .00 51. .59 1SG 962
ATOM 962 C ASN 125 145, .874 26. .020 -1, .469 1. .00 51, .59 1SG 963
ATOM 963 O ASN 125 145. .744 26 .979 -2 .228 1. .00 51, .59 1SG 964
ATOM 964 N GLU 126 144. .903 25 .579 -0 .647 1, .00 57, .69 1SG 965
ATOM 965 CA GLU 126 143. .576 26 .110 -0 .643 1. .00 57, .69 1SG 966
ATOM 966 CB GLU 126 142. .724 25, .620 0 .540 1. .00 57, .69 1SG 967
ATOM 967 CG GLU 126 142. .496 24, .107 0, .531 1. .00 57, .69 1SG 968
ATOM 968 CD GLU 126 141, .723 23, .747 -0 .730 1, .00 57, .69 1SG 969
ATOM 969 OEl GLU 126 141, .344 24, .683 -1, .484 1. .00 57, .69 1SG 970
ATOM 970 OE2 GLU 126 141. .501 22, .527 -0, .955 1. .00 57, .69 1SG 971
ATOM 971 C GLU 126 143. .647 27, .592 -0, .578 1. .00 57, .69 1SG 972
ATOM 972 O GLU 126 144 .409 28 .174 0 .193 1 .00 57 .69 1SG 973
ATOM 973 N PHE 127 142. .834 28 .233 -1 .433 1 .00 64 .38 1SG 974
ATOM 974 CA PHE 127 142. .806 29 .655 -1 .517 1 .00 64 .38 1SG 975
ATOM 975 CB PHE 127 142, .015 30, .179 -2 .728 1. .00 64 .38 1SG 976
ATOM 976 CG PHE 127 142, .736 29, .741 -3 .957 1, .00 64 .38 1SG 977
ATOM 977 CDl PHE 127 142, .610 28, .449 -4 .413 1, .00 64 .38 1SG 978
ATOM 978 CD2 PHE 127 143, .529 30, .619 -4, .659 1, .00 64, .38 1SG 979
ATOM 979 CE1 PHE 127 143, .270 28, .037 -5, .547 1. .00 64, .38 1SG 980
ATOM 980 CE2 PHE 127 144. .192 30, .213 -5, .794 1. .00 64, .38 1SG 981
ATOM 981 CZ PHE 127 144, .063 28 .920 -6 .240 1, .00 64 .38 1SG 982
ATOM 982 C PHE 127 142, .145 30 .149 -0 .289 1, .00 64 .38 1SG 983
ATOM 983 O PHE 127 141. .268 29, .499 0 .271 1. .00 64 .38 1SG 984
ATOM 984 N ASP 128 142, .577 31, .325 0 .178 1, .00 68, .07 1SG 985
ATOM 985 CA ASP 128 142, .068 31, .821 1 .411 1. .00 68, .07 1SG 986
ATOM 986 CB ASP 128 143, .223 32, .160 2, .380 1. .00 68, .07 1SG 987
ATOM 987 CG ASP 128 142, .741 32, .603 3, .762 1. .00 68, .07 1SG 988
ATOM 988 OD1 ASP 128 141, .596 33 , .114 3, .890 1. .00 68. .07 1SG 989
ATOM 989 OD2 ASP 128 143. .533 32, .420 4, .724 1. .00 68, .07 1SG 990
ATOM 990 C ASP 128 141. .315 33 .086 1 .173 1, .00 68 .07 1SG 991
ATOM 991 O ASP 128 141, .916 34, .131 0 .949 1, .00 68 .07 1SG 992
ATOM 992 N GLY 129 139, .974 33, .036 1 .234 1. .00 65, .53 1SG 993
ATOM 993 CA GLY 129 139. .235 34, .264 1, .222 1. .00 65, .53 1SG 994
ATOM 994 C GLY 129 139. .513 35, .053 -0, .007 1. .00 65, .53 1SG 995
ATOM 995 O GLY 129 139. .987 36, .183 0, .070 1. .00 65, .53 1SG 996
ATOM 996 N SER 130 139. .211 34, .486 -1, .180 1. .00 59, .65 1SG 997
ATOM 997 CA SER 130 139. .462 35. .180 -2. .404 1. .00 59. ,65 1SG 998
ATOM 998 CB SER 130 139. .136 34. .320 -3. .635 1. ,00 59. ,65 1SG 999
ATOM 999 OG SER 130 139. .945 33, .153 -3 .643 1. .00 59. .65 1SG1000
ATOM 1000 C SER 130 138. .584 36, .398 -2. .460 1. .00 59. .65 1SG1001
ATOM 1001 O SER 130 138, .759 37, .243 -3, .332 1. .00 59, .65 1SG1002
ATOM 1002 N ASN 131 137. .596 36, .505 -1. .549 1. .00 53, .83 1SG1003
ATOM 1003 CA ASN 131 136. .640 37. .583 -1, .560 1. .00 53. .83 1SG1004
ATOM 1004 CB ASN 131 135. .479 37. .364 -0. .576 1. ,00 53. .83 1SG1005
ATOM 1005 CG ASN 131 134. .534 36. .342 -1. .192 1. ,00 53. .83 1SG1006
ATOM 1006 OD1 ASN 131 134. .256 35. .294 -0. .612 1. ,00 53. .83 1SG1007
ATOM 1007 ND2 ASN 131 134. .019 36. ,661 -2. .410 1. ,00 53. .83 1SG1008
ATOM 1008 C ASN 131 137. .216 38. .941 -1. .266 1. .00 53. .83 1SG1009 cxι σι θ H CN r | ιn ιo m in ic io iD io iD io - o o o o o o o o o O O CD CD O D CD CD CD H
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ATOM 1066 O VAL 139 151.,047 34.222 5.665 1.00 94.,46 1SG1067
ATOM 1067 N LEU 140 150. 518 32. 078 5. ,147 1. 00 98. ,08 1SG1068
ATOM 1068 CA LEU 140 150. ,576 31. ,533 6. ,486 1. 00 98. .08 1SG1069
ATOM 1069 CB LEU 140 149. 301 31. 638 7. ,338 1. 00 98. .08 1SG1070
ATOM 1070 CG LEU 140 149. ,003 33. ,078 7. ,776 1. 00 98. .08 1SG1071
ATOM 1071 CD2 LEU 140 148. ,493 33. ,939 6. .617 1. ,00 98. .08 1SG1072
ATOM 1072 CDl LEU 140 150. ,223 33. ,678 8. .494 1. ,00 98. .08 1SG1073
ATOM 1073 C LEU 140 150. ,935 30. 068 6. .370 1. ,00 98. .08 1SG1074
ATOM 1074 O LEU 140 151. ,108 29. .574 5. .257 1. ,00 98. .08 1SG1075
ATOM 1075 N VAL 141 151. .083 29. .326 7. ,504 1. .00 92. .44 1SG1076
ATOM 1076 CA VAL 141 151, .499 27. ,943 7. ,390 1. .00 92. .44 1SG1077
ATOM 1077 CB VAL 141 152, .871 27. ,701 7. ,943 1, .00 92. .44 1SG1078
ATOM 1078 CGI VAL 141 153. .888 28. .493 7. .103 1. .00 92. .44 1SG1079
ATOM 1079 CG2 VAL 141 152. .861 28. .083 9. .432 1. .00 92. .44 1SG1080
ATOM 1080 C VAL 141 150. .571 26. .981 8. .084 1. ,00 92. .44 1SG1081
ATOM 1081 O VAL 141 150, .191 27. .141 9. ,246 1. .00 92, .44 1SG1082
ATOM 1082 N GLN 142 150. .195 25. .909 7, .356 1. .00 83, .83 1SG1083
ATOM 1083 CA GLN 142 149. .350 24. ,885 7. .903 1. .00 83, .83 1SG1084
ATOM 1084 CB GLN 142 148. .899 23. ,839 6. .870 1. .00 83. .83 1SG1085
ATOM 1085 CG GLN 142 147, .917 24. .381 5. .832 1. .00 83 .83 1SG1086
ATOM 1086 CD GLN 142 147, .562 23. .244 4. .890 1. .00 83 .83 1SG1087
ATOM 1087 OEl GLN 142 146 , .393 23. .028 4. .567 1. , 00 83 .83 1SG1088
ATOM 1088 NE2 GLN 142 148, .597 22. .489 4. .428 1. .00 83 .83 1SG1089
ATOM 1089 C GLN 142 150, .100 24. .154 8. .962 1. .00 83 .83 1SG1090
ATOM 1090 O GLN 142 149, .559 23. .867 10. .026 1. .00 83 .83 1SG1091
ATOM 1091 N LYS 143 151, .380 23, .842 8. .684 1. .00 75 .36 1SG1092
ATOM 1092 CA LYS 143 152, .215 23. .153 9. .622 1. .00 75 .36 1SG1093
ATOM 1093 CB LYS 143 152 .675 24, .020 10. .808 1. .00 75 .36 1SG1094
ATOM 1094 CG LYS 143 153, .674 25. .117 10. .433 1. .00 75 .36 1SG1095
ATOM 1095 CD LYS 143 153, .893 26. .140 11. .550 1. .00 75 .36 1SG1096
ATOM 1096 CE LYS 143 154 .992 27, .161 11. .250 1 .00 75 .36 1SG1097
ATOM 1097 NZ LYS 143 155, .121 28, .109 12. .380 1. .00 75 .36 1SG1098
ATOM 1098 C LYS 143 151 .513 21, .957 10. .177 1. .00 75 .36 1SG1099
ATOM 1099 O LYS 143 150 .487 21 .505 9. .671 1. .00 75 .36 1SG1100
ATOM 1100 N HIS 144 152 .119 21, .413 11. .247 1 .00 68 .29 1SG1101
ATOM 1101 CA HIS 144 151, .694 20, .267 11. .994 1. .00 68 .29 1SG1102
ATOM 1102 NDl HIS 144 151 .624 18, .530 14, .927 1 .00 68 .29 1SG1103
ATOM 1103 CG HIS 144 152 .379 18 .588 13 .777 1 .00 68 .29 1SG1104
ATOM 1104 CB HIS 144 152 .726 19. .858 13. .059 1. .00 68 .29 1SG1105
ATOM 1105 NE2 HIS 144 152 .177 16. .435 14, .424 1. .00 68 .29 1SG1106
ATOM 1106 CD2 HIS 144 152 .707 17 .300 13, .483 1. .00 68 .29 1SG1107
ATOM 1107 CE1 HIS 144 151 .535 17 .220 15 .271 1 .00 68 .29 1SG1108
ATOM 1108 C HIS 144 150 .426 20 .614 12, .696 1, .00 68 .29 1SG1109
ATOM 1109 O HIS 144 149 .617 19, .745 13 .021 1. .00 68 .29 1SG1110
ATOM 1110 N ILE 145 150 .223 21 .915 12, .952 1. .00 65 .47 1SG1111
ATOM llll CA ILE 145 149 .091 22, .332 13, .715 1. .00 65 .47 1SG1112
ATOM 1112 CB ILE 145 149 .020 23 .824 13, .899 1. .00 65 .47 1SG1113
ATOM 1113 CG2 ILE 145 148 .672 24 .459 12, .549 1 .00 65 .47 1SG1114
ATOM 1114 CGI ILE 145 148 .052 24 .227 15 .028 1 .00 65 .47 1SG1115
ATOM 1115 CDl ILE 145 146 .577 23, .967 14. .730 1, .00 65 .47 1SG1116
ATOM 1116 C ILE 145 147 .845 21 .841 13. .052 1, .00 65 .47 1SG1117
ATOM 1117 O ILE 145 146 .902 21 .440 13. .729 1 .00 65 .47 1SG1118
ATOM 1118 N LYS 146 147 .798 21 .830 11. .711 1, .00 62 .67 1SG1119
ATOM 1119 CA LYS 146 146 .580 21 .436 11. .065 1, .00 62 .67 1ΞG1120
ATOM 1120 CB LYS 146 146 .680 21 .476 9, .528 1, .00 62 .67 1SG1121
ATOM 1121 CG LYS 146 147 .761 20 .567 8, .941 1, .00 62 .67 1SG1122
ATOM 1122 CD LYS 146 147 .669 20, .422 7, .420 1, .00 62 .67 1SG1123 ATOM 1123 CE LYS 146 148.786 19.,570 6.813 1.00 62.67 1SG1124
ATOM 1124 NZ LYS 146 148. .550 18. ,141 7. ,113 1. 00 62. 67 1SG1125
ATOM 1125 C LYS 146 146. 169 20. ,056 11. ,484 1. 00 62. 67 1SG1126
ATOM 1126 O LYS 146 144. ,999 19. ,819 11. ,780 1. 00 62. 67 1SG1127
ATOM 1127 N ALA 147 147. 111 19. .102 11. ,550 1. 00 57. 48 1SG1128
ATOM 1128 CA ALA 147 146. ,695 17. .771 11. ,891 1. 00 57. .48 1SG1129
ATOM 1129 CB ALA 147 147. .857 16. .764 11. .878 1. ,00 57. .48 1SG1130
ATOM 1130 C ALA 147 146. ,101 17. .755 13. .264 1. 00 57. .48 1SG1131
ATOM 1131 O ALA 147 145. .034 17. .182 13. .483 1. 00 57. 48 1SG1132
ATOM 1132 N VAL 148 146. .774 18. .404 14, .230 1. .00 54. .05 1SG1133
ATOM 1133 CA VAL 148 146. .299 18. .382 15. .584 1. .00 54. .05 1SG1134
ATOM 1134 CB VAL 148 147. .275 18. ,971 16. .565 1. ,00 54. .05 1SG1135
ATOM 1135 CGI VAL 148 148. .530 18. .081 16. .577 1. ,00 54. .05 1SG1136
ATOM 1136 CG2 VAL 148 147. .570 20. .430 16. .186 1. .00 54. .05 1SG1137
ATOM 1137 C VAL 148 145. .008 19, .124 15. .665 1. .00 54. .05 1SG1138
ATOM 1138 O VAL 148 144. ,119 18. ,787 16. .447 1. .00 54. ,05 1SG1139
ATOM 1139 N LEU 149 144. ,882 20. .180 14. .851 1. ,00 52. .00 1SG1140
ATOM 1140 CA LEU 149 143. , 715 20. .999 14. .903 1. .00 52. .00 1SG1141
ATOM 1141 CB LEU 149 143. .806 22, .192 13. .933 1. .00 52. .00 1SG1142
ATOM 1142 CG LEU 149 142, .629 23, .180 14. .033 1. .00 52. .00 1SG1143
ATOM 1143 CD2 LEU 149 142. .579 24. .121 12, ,819 1. .00 52. .00 1SG1144
ATOM 1144 CDl LEU 149 142. .656 23. .935 15. ,371 1. .00 52. .00 1SG1145
ATOM 1145 C LEU 149 142. .516 20 .201 14 .514 1, .00 52. .00 1SG1146
ATOM 1146 O LEU 149 141. .469 20. .289 15. .152 1. .00 52. .00 1SG1147
ATOM 1147 N SER 150 142. .641 19. .379 13. ,461 1. .00 51. .74 1SG1148
ATOM 1148 CA SER 150 141, .500 18. .677 12. .957 1. .00 51, .74 1SG1149
ATOM 1149 CB SER 150 141, .839 17 .779 11 .755 1, .00 51, .74 1SG1150
ATOM 1150 OG SER 150 142, .268 18. .574 10. .660 1. .00 51. .74 1SG1151
ATOM 1151 C SER 150 140. .905 17, .809 14, .010 1. .00 51. .74 1SG1152
ATOM 1152 O SER 150 139, .686 17. .782 14, .170 1. .00 51. .74 1SG1153
ATOM 1153 N ASN 151 141 .744 17 .056 14 .741 1. .00 56. .07 1SG1154
ATOM 1154 CA ASN 151 141. .190 16, .154 15. .703 1. .00 56. .07 1SG1155
ATOM 1155 CB ASN 151 142. .206 15 .143 16 .270 1, .00 56. .07 1SG1156
ATOM 1156 CG ASN 151 143. .300 15, .883 17. .023 1. .00 56, .07 1SG1157
ATOM 1157 OD1 ASN 151 144. .317 16, .259 16 .443 1. .00 56 .07 1SG1158
ATOM 1158 ND2 ASN 151 143 .090 16 .094 18 .350 1, .00 56 .07 1SG1159
ATOM 1159 C ASN 151 140. .553 16 .870 16 .853 1, .00 56, .07 1SG1160
ATOM 1160 O ASN 151 139. .439 16, .528 17, .249 1. .00 56, .07 1SG1161
ATOM 1161 N LYS 152 141. .221 17 .890 17 .427 1 .00 58 .68 1SG1162
ATOM 1162 CA LYS 152 140 .631 18 .461 18 .604 1, .00 58 .68 1SG1163
ATOM 1163 CB LYS 152 141. .479 19 .477 19 .397 1, .00 58 .68 1SG1164
ATOM 1164 CG LYS 152 141, .690 20 .844 18 .747 1. .00 58, .68 1SG1165
ATOM 1165 CD LYS 152 142, .793 20, .880 17 .696 1, .00 58 .68 1SG1166
ATOM 1166 CE LYS 152 144 .180 20 .988 18 .336 1, .00 58 .68 1SG1167
ATOM 1167 NZ LYS 152 145, .155 21, .532 17 .369 1, .00 58. .68 1SG1168
ATOM 1168 C LYS 152 139, .327 19 .124 18 .299 1, .00 58, .68 1SG1169
ATOM 1169 O LYS 152 138, .383 19 .019 19 .082 1, .00 58. .68 1SG1170
ATOM 1170 N LEU 153 139, .226 19 .828 17 .158 1, .00 58 .14 1SG1171
ATOM 1171 CA LEU 153 138 .016 20 .549 16 .894 1 .00 58 .14 1SG1172
ATOM 1172 CB LEU 153 138, .078 21 .426 15 .631 1, .00 58 .14 1SG1173
ATOM 1173 CG LEU 153 138, .860 22, .734 15 .855 1, .00 58. .14 1SG1174
ATOM 1174 CD2 LEU 153 138 .805 23 .639 14 .614 1 .00 58 .14 1SG1175
ATOM 1175 CDl LEU 153 140 .292 22 .462 16 .334 1 .00 58 .14 1SG1176
ATOM 1176 C LEU 153 136, .840 19 .633 16 .790 1, .00 58 .14 1SG1177
ATOM 1177 O LEU 153 135 .791 19 .914 17 .367 1 .00 58 .14 1SG1178
ATOM 1178 N CYS 154 136, .976 18 .503 16 .081 1 .00 56 .58 1SG1179
ATOM 1179 CA CYS 154 135 .852 17 .626 15 .947 1 .00 56 .58 1SG1180 ATOM 1180 CB CYS 154 136..148 16.347 15.159 1..00 56.58 1SG1181
ATOM 1181 SG CYS 154 134. .807 15. .152 15 .414 1. .00 56 .58 1SG1182
ATOM 1182 C CYS 154 135. .445 17 .143 17 .293 1, .00 56 .58 1SG1183
ATOM 1183 O CYS 154 134, .256 16 .991 17 .569 1 .00 56 .58 1SG1184
ATOM 1184 N LEU 155 136, .428 16. .861 18. .164 1. .00 51. .28 1SG1185
ATOM 1185 CA LEU 155 136, .084 16 .325 19 .443 1. .00 51 .28 1SG1186
ATOM 1186 CB LEU 155 137 .306 16 .038 20 .329 1 .00 51 .28 1SG1187
ATOM 1187 CG LEU 155 136 .929 15 .461 21 .706 1 .00 51 .28 1SG1188
ATOM 1188 CD2 LEU 155 138, .138 15. .425 22 .652 1. .00 51 .28 1SG1189
ATOM 1189 CDl LEU 155 136, .236 14 .096 21 .570 1. .00 51 .28 1SG1190
ATOM 1190 C LEU 155 135 .233 17 .312 20 .170 1 .00 51 .28 1SG1191
ATOM 1191 O LEU 155 134, .214 16 .951 20 .756 1. .00 51 .28 1SG1192
ATOM 1192 N SER 156 135, .628 18. .594 20 .143 1, .00 47 .26 1SG1193
ATOM 1193 CA SER 156 134, .901 19 .587 20 .872 1. .00 47 .26 1SG1194
ATOM 1194 CB SER 156 135 .547 20 .983 20 .779 1 .00 47 .26 1SG1195
ATOM 1195 OG SER 156 136, .833 20 .968 21 .381 1. .00 47 .26 1SG1196
ATOM 1196 C SER 156 133, .508 19. .717 20 .336 1. .00 47 .26 1SG1197
ATOM 1197 O SER 156 132, .534 19 .684 21 .085 1, .00 47 .26 1SG1198
ATOM 1198 N ILE 157 133, .366 19. .835 19 .007 1, .00 45 .43 1SG1199
ATOM 1199 CA ILE 157 132, .071 20 .105 18 .455 1, .00 45 .43 1SG1200
ATOM 1200 CB ILE 157 132. .096 20 .261 16 .960 1 .00 45 .43 1SG1201
ATOM 1201 CG2 ILE 157 132 .975 21 .479 16 .629 1, .00 45 .43 1SG1202
ATOM 1202 CGI ILE 157 132, .554 18. .960 16 .282 1. .00 45 .43 1SG1203
ATOM 1203 CDl ILE 157 132 .337 18 .958 1 .769 1, .00 45 .43 1SG1204
ATOM 1204 C ILE 157 131, .109 19. .012 18 .790 1 .00 45 .43 1SG1205
ATOM 1205 O ILE 157 129. .977 19, .279 19, .192 1. .00 45 .43 1SG1206
ATOM 1206 N SER 158 131, .526 17, .745 18 .650 1. .00 42 .97 1SG1207
ATOM 1207 CA SER 158 130, .599 16 .682 18 .888 1. .00 42 .97 1SG1208
ATOM 1208 CB SER 158 131 .210 15 .294 18 .628 1 .00 42 .97 1SG1209
ATOM 1209 OG SER 158 132. .327 15, ,080 19, .476 1. .00 42 .97 1SG1210
ATOM 1210 C SER 158 130. .101 16, .731 20 .301 1. .00 42 .97 1SG1211
ATOM 1211 O SER 158 128. .901 16 ,602 20 .536 1, .00 42 .97 1SG1212
ATOM 1212 N ASN 159 130. .998 16, .930 21 .286 1. .00 42 .12 1SG1213
ATOM 1213 CA ASN 159 130. .560 16, .894 22, .654 1. .00 42. .12 1SG1214
ATOM 1214 CB ASN 159 131. .703 16, .871 23 .689 1, .00 42 .12 1SG1215
ATOM 1215 CG ASN 159 132. .492 18 .167 23 .638 1. .00 42 .12 1SG1216
ATOM 1216 OD1 ASN 159 133. .507 18, .272 22 .952 1. .00 42 .12 1SG1217
ATOM 1217 ND2 ASN 159 132. .014 19, .184 24, .402 1. ,00 42, .12 1SG1218
ATOM 1218 C ASN 159 129. .636 18, .035 22 .967 1, .00 42 .12 1SG1219
ATOM 1219 O ASN 159 128. .655 17, .855 23, .688 1. .00 42, .12 1SG1220
ATOM 1220 N LEU 160 129. .902 19, .240 22, .426 1. .00 39 .39 1SG1221
ATOM 1221 CA LEU 160 129. .074 20, .378 22, .733 1. .00 39, .39 1SG1222
ATOM 1222 CB LEU 160 129. .537 21, .711 22, .107 1. .00 39, .39 1SG1223
ATOM 1223 CG LEU 160 130. .666 22. .442 22. .864 1. .00 39, .39 1SG1224
ATOM 1224 CD2 LEU 160 131. .967 21, .634 22, .918 1. .00 39, .39 1SG1225
ATOM 1225 CDl LEU 160 130. .190 22, .893 24. .253 1. .00 39 .39 1SG1226
ATOM 1226 C LEU 160 127. .672 20. ,144 22. .271 1. 00 39. .39 1SG1227
ATOM 1227 O LEU 160 126. ,727 20. .625 22. .896 1. .00 39. .39 1SG1228
ATOM 1228 N VAL 161 127. .496 19. .395 21. .170 1. .00 34. .66 1SG1229
ATOM 1229 CA VAL 161 126. ,190 19, .201 20. .607 1. .00 34, .66 1SG1230
ATOM 1230 CB VAL 161 126. ,188 18. ,234 19. ,460 1. 00 34. .66 1SG1231
ATOM 1231 CGI VAL 161 124. ,734 18. .014 19. .011 1. .00 34. .66 1SG1232
ATOM 1232 CG2 VAL 161 127. .105 18. .787 18. .356 1. .00 34. .66 1SG1233
ATOM 1233 C VAL 161 125. .286 18, .650 21. .658 1. 00 34. .66 1SG1234
ATOM 1234 O VAL 161 124. 119 19. .030 21. .735 1. 00 34. .66 1SG1235
ATOM 1235 N GLN 162 125. ,806 17. .758 22. .517 1. 00 31. .59 1SG1236
ATOM 1236 CA GLN 162 124. 971 17, ,190 23. ,532 1. 00 31. ,59 1SG1237 ATOM 1237 CB GLN 162 125,,722 16.,243 24.,486 1..00 31.,59 1SG1238
ATOM 1238 CG GLN 162 126. ,131 14. ,909 23. ,858 1. .00 31. ,59 1SG1239
ATOM 1239 CD GLN 162 127. .205 15. ,171 22. .814 1. .00 31. .59 1SG1240
ATOM 1240 OEl GLN 162 126. .903 15. .530 21. .677 1. ,00 31. .59 1SG1241
ATOM 1241 NE2 GLN 162 128. .493 14. .981 23. .205 1. .00 31. .59 1SG1242
ATOM 1242 C GLN 162 124. ,427 18. .313 24. ,363 1. ,00 31. ,59 1SG1243
ATOM 1243 O GLN 162 123. ,263 18. .288 24. .755 1. ,00 31. .59 1SG1244
ATOM 1244 N GLY 163 125. .255 19. ,336 24. .644 1. .00 28. .30 1SG1245
ATOM 1245 CA GLY 163 124. .826 20. ,458 25. .433 1. .00 28. .30 1SG1246
ATOM 1246 C GLY 163 123, .719 21. .157 24. .711 1. .00 28. .30 1SG1247
ATOM 1247 O GLY 163 122. .784 21. .668 25. .324 1. .00 28. .30 1SG1248
ATOM 1248 N VAL 164 123. .808 21. .220 23 , .373 1. .00 27. .71 1SG1249
ATOM 1249 CA VAL 164 122. .808 21. .909 22. .612 1. .00 27. .71 1SG1250
ATOM 1250 CB VAL 164 123, .086 21. .888 21. .138 1. .00 27, .71 1SG1251
ATOM 1251 CGI VAL 164 121, .911 22. .562 20. .410 1, .00 27, .71 1SG1252
ATOM 1252 CG2 VAL 164 124, .446 22 , .563 20. .888 1. .00 27, .71 1SG1253
ATOM 1253 C VAL 164 121, .492 21. .236 22. .829 1, .00 27, .71 1SG1254
ATOM 1254 O VAL 164 120. .458 21. .892 22. .945 1. .00 27. .71 1SG1255
ATOM 1255 N ASN 165 121. .503 19. .894 22. .899 1. .00 30. .05 1SG1256
ATOM 1256 CA ASN 165 120. .290 19. .140 23, .017 1. .00 30. .05 1SG1257
ATOM 1257 CB ASN 165 120, .550 17, .625 23, .076 1. .00 30, .05 1SG1258
ATOM 1258 CG ASN 165 119, .227 16. .897 22, .877 1. .00 30, .05 1SG1259
ATOM 1259 OD1 ASN 165 119. .155 15, .677 23 .015 1. .00 30, .05 1SG1260
ATOM 1260 ND2 ASN 165 118. .154 17. .658 22 .537 1. .00 30 .05 1SG1261
ATOM 1261 C ASN 165 119, .563 19. .523 24, .271 1, .00 30 .05 1SG1262
ATOM 1262 O ASN 165 118 .343 19. .679 24 .260 1 .00 30 .05 1SG1263
ATOM 1263 N VAL 166 120 .287 19, .701 25 .391 1 .00 32 .76 1SG1264
ATOM 1264 CA VAL 166 119 .622 19 .975 26 .634 1 .00 32 .76 1SG1265
ATOM 1265 CB VAL 166 120, .549 20, .105 27, .811 1, .00 32, .76 1SG1266
ATOM 1266 CGI VAL 166 121, .354 18, .803 27 .947 1, .00 32, .76 1SG1267
ATOM 1267 CG2 VAL 166 121 .391 21, .381 27 .663 1, .00 32 .76 1SG1268
ATOM 1268 C VAL 166 118 .863 21, .260 26 .527 1 .00 32 .76 1SG1269
ATOM 1269 O VAL 166 117 .771 21, .384 27 .077 1 .00 32 .76 1SG1270
ATOM 1270 N HIS 167 119 .427 22 .259 25 .825 1 .00 37 .11 1SG1271
ATOM 1271 CA HIS 167 118 .787 23 .542 25 .729 1 .00 37 .11 1SG1272
ATOM 1272 NDl HIS 167 122 .087 24 .302 25 .437 1 .00 37 .11 1SG1273
ATOM 1273 CG HIS 167 120 .891 24 .963 25 .604 1 .00 37 .11 1SG1274
ATOM 1274 CB HIS 167 119 .610 24 .570 24 .931 1 .00 37 .11 1SG1275
ATOM 1275 NE2 HIS 167 122 .480 25 .980 26 .843 1 .00 37 .11 1SG1276
ATOM 1276 CD2 HIS 167 121, .148 25, .984 26 .467 1. .00 37, .11 1SG1277
ATOM 1277 CE1 HIS 167 123, .003 24, .952 26 .199 1, .00 37, .11 1SG1278
ATOM 1278 C HIS 167 117 .462 23, .414 25 .038 1 .00 37, .11 1SG1279
ATOM 1279 O HIS 167 116 .471 24, .004 25 .466 1 .00 37, .11 1SG1280
ATOM 1280 N LEU 168 117 .411 22 .624 23 .952 1 .00 42 .46 1SG1281
ATOM 1281 CA LEU 168 116 .230 22 .455 23 .147 1, .00 42, .46 1SG1282
ATOM 1282 CB LEU 168 116 .475 21 .560 21 .921 1 .00 42 .46 1SG1283
ATOM 1283 CG LEU 168 117 .488 22 .155 20 .925 1 .00 42 .46 1SG1284
ATOM 1284 CD2 LEU 168 117 .097 23 .585 20 .518 1 .00 42 .46 1SG1285
ATOM 1285 CDl LEU 168 117 .695 21 .228 19 .718 1 .00 42 .46 1SG1286
ATOM 1286 C LEU 168 115 .154 21 .819 23 .969 1 .00 42 .46 1SG1287
ATOM 1287 O LEU 168 113 .967 21 .988 23 .697 1 .00 42 .46 1SG1288
ATOM 1288 N GLY 169 115, .562 21. .034 24 .976 1, .00 48, .43 1SG1289
ATOM 1289 CA GLY 169 114, .705 20 .313 25 .874 1, .00 48, .43 1SG1290
ATOM 1290 C GLY 169 113, .882 21, .276 26 .667 1, .00 48, .43 1SG1291
ATOM 1291 O GLY 169 112. .862 20 .903 27 .241 1. .00 48, .43 1SG1292
ATOM 1292 N THR 170 114 .351 22, .530 26 .766 1, .00 53, .48 1SG1293
ATOM 1293 CA THR 170 113 .746 23 .561 27 .555 1 .00 53 .48 1SG1294 ATOM 1294 CB THR 170 114..481 24..859 27..485 1.,00 53..48 1SG1295
ATOM 1295 OGl THR 170 115. .831 24. .686 27. .887 1. ,00 53. ,48 1SG1296
ATOM 1296 CG2 THR 170 113. .775 25. .831 28. .439 1. .00 53. ,48 1SG1297
ATOM 1297 C THR 170 112. .347 23. .832 27. .089 1. .00 53. ,48 1SG1298
ATOM 1298 O THR 170 111. .540 24. .341 27. .864 1. .00 53. ,48 1SG1299
ATOM 1299 N LEU 171 112. .030 23. ,550 25. .809 1. .00 57. .72 1SG1300
ATOM 1300 CA LEU 171 110. .702 23. ,807 25. .315 1. .00 57. .72 1SG1301
ATOM 1301 CB LEU 171 110. .421 23. .240 23. .913 1. .00 57. .72 1SG1302
ATOM 1302 CG LEU 171 111. .011 24. .056 22. .758 1. ,00 57. .72 1SG1303
ATOM 1303 CD2 LEU 171 110. .525 25, ,513 22. .815 1. .00 57. .72 1SG1304
ATOM 1304 CDl LEU 171 110. .676 23 , .408 21. .408 1. .00 57. .72 1SG1305
ATOM 1305 C LEU 171 109. .705 23. ,154 26. .218 1. ,00 57. .72 1SG1306
ATOM 1306 O LEU 171 109. .922 22. ,050 26, .712 1. .00 57. .72 1SG1307
ATOM 1307 N ILE 172 108. .569 23. ,839 26, .470 1. .00 59. ,24 1SG1308
ATOM 1308 CA ILE 172 107, .651 23. .270 27, .406 1. .00 59. .24 1SG1309
ATOM 1309 CB ILE 172 106. .924 24. .291 28, .237 1. .00 59. .24 1SG1310
ATOM 1310 CG2 ILE 172 105. .892 25. .008 27, .350 1. .00 59. .24 1SG1311
ATOM 1311 CGI ILE 172 106. .337 23. .617 29, .487 1. .00 59. .24 1SG1312
ATOM 1312 CDl ILE 172 106. .039 24. .596 30 .620 1, .00 59, .24 1SG1313
ATOM 1313 C ILE 172 106. .677 22. .382 26 .703 1, .00 59, .24 1SG1314
ATOM 1314 O ILE 172 106. .007 22. .780 25, .752 1. .00 59, .24 1SG1315
ATOM 1315 N GLY 173 106, .675 21. .094 27, .103 1. .00 57, .66 1SG1316
ATOM 1316 CA GLY 173 105. .756 20. .133 26, .574 1. .00 57, .66 1SG1317
ATOM 1317 C GLY 173 104. .407 20, .301 27 .187 1. .00 57, .66 1SG1318
ATOM 1318 O GLY 173 103, .385 20, .311 26 .506 1. .00 57 .66 1SG1319
ATOM 1319 N LEU 174 104, .382 20, .421 28, .525 1. .00 56. .98 1SG1320
ATOM 1320 CA LEU 174 103 , .144 20, .502 29, .229 1. .00 56, .98 1SG1321
ATOM 1321 CB LEU 174 102, .973 19. .249 30, .114 1. .00 56, .98 1SG1322
ATOM 1322 CG LEU 174 101, .793 19. .249 31 .091 1, .00 56 .98 1SG1323
ATOM 1323 CD2 LEU 174 100. .519 19, .743 30 .395 1. .00 56, .98 1SG1324
ATOM 1324 CDl LEU 174 102, .135 20. .031 32, .366 1. .00 56, .98 1SG1325
ATOM 1325 C LEU 174 103 , .203 21. .739 30, .053 1. .00 56, .98 1SG1326
ATOM 1326 O LEU 174 103 .836 21. .762 31 .106 1. .00 56 .98 1SG1327
ATOM 1327 N ASN 175 102, .551 22, .829 29 .602 1. .00 53 .14 1SG1328
ATOM 1328 CA ASN 175 102, .671 23 , .946 30 .481 1. .00 53, .14 1SG1329
ATOM 1329 CB ASN 175 103 , .266 25, .261 29 .905 1. .00 53, .14 1SG1330
ATOM 1330 CG ASN 175 102. .386 26. .032 28, .931 1. .00 53, .14 1SG1331
ATOM 1331 OD1 ASN 175 101. .201 26. .278 29 .147 1. .00 53, .14 1SG1332
ATOM 1332 ND2 ASN 175 103, .027 26. .495 27 .824 1. .00 53, .14 1SG1333
ATOM 1333 C ASN 175 101, .349 24, .209 31 .119 1. .00 53, .14 1SG1334
ATOM 1334 O ASN 175 100, .310 24, .316 30, .467 1. .00 53, .14 1SG1335
ATOM 1335 N PRO 176 101, .381 24, .190 32 .424 1. .00 49, .05 1SG1336
ATOM 1336 CA PRO 176 100, .210 24, .520 33 .183 1. .00 49. .05 1SG1337
ATOM 1337 CD PRO 176 102, .254 23. .282 33, .145 1. .00 49. .05 1SG1338
ATOM 1338 CB PRO 176 100. .399 23. .905 34, .571 1. .00 49, .05 1SG1339
ATOM 1339 CG PRO 176 101. .887 23. .510 34, .619 1. .00 49. .05 1SG1340
ATOM 1340 C PRO 176 100. .016 26. .000 33 .213 1, .00 49. .05 1SG1341
ATOM 1341 O PRO 176 100. .930 26. .704 33 .642 1, .00 49. .05 1SG1342
ATOM 1342 N VAL 177 98, .851 26. .493 32 .753 1. .00 45. .69 1SG1343
ATOM 1343 CA VAL 177 98. .553 27. .895 32, .804 1. .00 45. .69 1SG1344
ATOM 1344 CB VAL 177 97. .491 28. .304 31 .826 1. .00 45. .69 1SG1345
ATOM 1345 CGI VAL 177 96, .171 27, .620 32 .213 1. .00 45, .69 1SG1346
ATOM 1346 CG2 VAL 177 97, .412 29. .840 31, .810 1. .00 45, .69 1SG1347
ATOM 1347 C VAL 177 98. .097 28. .293 34, .174 1. .00 45. .69 1SG1348
ATOM 1348 O VAL 177 98. .457 29. .358 34, .674 1. .00 45. .69 1SG1349
ATOM 1349 N GLY 178 97, .269 27. .436 34 .808 1. .00 41, .24 1SG1350
ATOM 1350 CA GLY 178 96. .697 27. .752 36 .084 1. .00 41, .24 1SG1351 ATOM 1351 C GLY 178 96..186 26.475 36..662 1,.00 41,.24 1SG1352
ATOM 1352 O GLY 178 96. .560 25 .388 36. .229 1, .00 41, .24 1SG1353
ATOM 1353 N PRO 179 95. .363 26 .573 37, .663 1, .00 41, .41 1SG1354
ATOM 1354 CA PRO 179 94, .847 25 .377 38, .259 1. .00 41, .41 1SG1355
ATOM 1355 CD PRO 179 95, .455 27 .667 38, .616 1. .00 41, .41 1SG1356
ATOM 1356 CB PRO 179 94, .172 25 .823 39. .554 1, .00 41, .41 1SG1357
ATOM 1357 CG PRO 179 94, .959 27 .087 39. .951 1, .00 41. .41 1SG1358
ATOM 1358 C PRO 179 93, .976 24 .566 37. .348 1. .00 41. .41 1SG1359
ATOM 1359 O PRO 179 93, .996 23, .342 37, .464 1. .00 41, .41 1SG1360
ATOM 1360 N GLU 180 93, .158 25 .217 36. .496 1. .00 44. .12 1SG1361
ATOM 1361 CA GLU 180 92, .251 24, .509 35. .635 1. .00 44. .12 1SG1362
ATOM 1362 CB GLU 180 91, .126 25 .422 35. .120 1. .00 44. .12 1SG1363
ATOM 1363 CG GLU 180 90 .196 25 .922 36 .227 1 .00 44, .12 1SG1364
ATOM 1364 CD GLU 180 89 .154 26 .831 35. .593 1. .00 44, .12 1SG1365
ATOM 1365 OEl GLU 180 89 .239 27 .054 34. .356 1, .00 44, .12 1SG1366
ATOM 1366 OE2 GLU 180 88 .261 27 .319 36. .337 1, .00 44 .12 1SG1367
ATOM 1367 C GLU 180 92 .881 23 .877 34, .421 1, .00 44 .12 1SG1368
ATOM 1368 O GLU 180 92 .775 22 .668 34, .220 1, .00 44 .12 1SG1369
ATOM 1369 N SER 181 93 .597 24 .671 33, .594 1, .00 48 .77 1SG1370
ATOM 1370 CA SER 181 94, .001 24 .175 32, .304 1. .00 48 .77 1SG1371
ATOM 1371 CB SER 181 93 .426 25 .010 31, .147 1, .00 48 .77 1SG1372
ATOM 1372 OG SER 181 93, .920 26 .339 31, .197 1, .00 48, .77 1SG1373
ATOM 1373 C SER 181 95, .482 24 .165 32, .126 1, .00 48, .77 1SG1374
ATOM 1374 O SER 181 96, .242 24 .651 32 , .961 1, .00 48, .77 1SG1375
ATOM 1375 N GLN 182 95, .909 23, .557 30, .996 1, .00 56, .02 1SG1376
ATOM 1376 CA GLN 182 97, .294 23 .396 30, .679 1, .00 56, .02 1SG1377
ATOM 1377 CB GLN 182 97, .808 22, .154 31, .416 1, .00 56, .02 1SG1378
ATOM 1378 CG GLN 182 99 .298 22 .084 31, .706 1 .00 56 .02 1SG1379
ATOM 1379 CD GLN 182 99 .408 21 .034 32, .804 1 .00 56 .02 1SG1380
ATOM 1380 OEl GLN 182 100 .113 21 .207 33 .796 1, .00 56 .02 1SG1381
ATOM 1381 NE2 GLN 182 98 .679 19 .901 32, .626 1, .00 56 .02 1SG1382
ATOM 1382 C GLN 182 97 .334 23 .177 29, .192 1, .00 56, .02 1SG1383
ATOM 1383 O GLN 182 96 .328 22 .798 28, .595 1. .00 56, .02 1SG1384
ATOM 1384 N ILE 183 98 .486 23 .425 28, .539 1, .00 61, .36 1SG1385
ATOM 1385 CA ILE 183 98, .562 23 .230 27, .116 1, .00 61, .36 1SG1386
ATOM 1386 CB ILE 183 98, .896 24 .464 26, .320 1, .00 61, .36 1SG1387
ATOM 1387 CG2 ILE 183 97, .652 25, .345 26. .209 1. .00 61, .36 1SG1388
ATOM 1388 CGI ILE 183 100, .135 25, .171 26. .877 1, .00 61, .36 1SG1389
ATOM 1389 CDl ILE 183 101. .442 24, .429 26. .646 1. .00 61, .36 1SG1390
ATOM 1390 C ILE 183 99. .563 22, .173 26. .806 1, .00 61, .36 1SG1391
ATOM 1391 O ILE 183 100. .562 21, .996 27. .503 1, .00 61, .36 1SG1392
ATOM 1392 N ARG 184 99. .291 21, .400 25. .743 1. .00 63. .02 1SG1393
ATOM 1393 CA ARG 184 100, .239 20, .388 25, .416 1. .00 63, .02 1SG1394
ATOM 1394 CB ARG 184 99, .597 19, .013 25, .156 1. .00 63, .02 1SG1395
ATOM 1395 CG ARG 184 100, .598 17, .856 25. .146 1. .00 63 , .02 1SG1396
ATOM 1396 CD ARG 184 101, .240 17, .583 26, .508 1. .00 63. .02 1SG1397
ATOM 1397 NE ARG 184 102, .161 16, .423 26. .339 1. .00 63. .02 1SG1398
ATOM 1398 CZ ARG 184 101, .692 15. .154 26. .513 1. .00 63. .02 1SG1399
ATOM 1399 NHl ARG 184 100, .387 14. .950 26. .858 1. .00 63. .02 1SG1400
ATOM 1400 NH2 ARG 184 102. .526 14. .087 26. .340 1. .00 63. .02 1SG1401
ATOM 1401 C ARG 184 100. .948 20, .824 24. .175 1. .00 63. .02 1SG1402
ATOM 1402 O ARG ■184 100. .348 20, .916 23. .105 1. .00 63. .02 1SG1403
ATOM 1403 N TYR 185 102. .257 21. .132 24. ,292 1. .00 63. .95 1SG1404
ATOM 1404 CA TYR 185 102. .997 21. .488 23. ,117 1. ,00 63. .95 1SG1405
ATOM 1405 CB TYR 185 103. ,892 22. .739 23. .237 1. ,00 63. ,95 1SG1406
ATOM 1406 CG TYR 185 103. ,080 23. .989 23. ,297 1. .00 63. ,95 1SG1407
ATOM 1407 CDl TYR 185 102. ,230 24. .329 22. ,270 1. .00 63. ,95 1SG1408 ATOM 1408 CD2 TYR 185 103.224 24.860 24..351 1.,00 63.,95 1SG1409
ATOM 1409 CE1 TYR 185 101. .496 25. ,492 22. .317 1. ,00 63. ,95 1SG1410
ATOM 1410 CE2 TYR 185 102. 495 26. 025 24. .405 1. .00 63. 95 1SG1411
ATOM 1411 CZ TYR 185 101. 625 26. 341 23. .390 1. 00 63. 95 1SG1412
ATOM 1412 OH TYR 185 100. .877 27. 535 23. .443 1. ,00 63. 95 1SG1413
ATOM 1413 C TYR 185 103. .941 20. .369 22. .798 1. .00 63. .95 1SG1414
ATOM 1414 O TYR 185 105. 102 20. .602 22. .465 1. .00 63. ,95 1SG1415
ATOM 1415 N SER 186 103. ,45θ' 19. .119 22. .831 1. ,00 60. ,76 1SG1416
ATOM 1416 CA SER 186 104. .276 17. .974 22. .559 1. .00 60. ,76 1SG1417
ATOM 1417 CB SER 186 103. .622 16. .649 22. .988 1. .00 60. .76 1SG1418
ATOM 1418 OG SER 186 104. ,446 15. ,551 22. .623 1. .00 60. .76 1SG1419
ATOM 1419 C SER 186 104. ,508 17. .873 21. .087 1. .00 60. .76 1SG1420
ATOM 1420 O SER 186 103. ,630 18. ,179 20. .284 1. . 00 60. , 76 1SG1421
ATOM 1421 N MET 187 105. ,715 17. .415 20. .697 1. .00 55. .72 1SG1422
ATOM 1422 CA MET 187 106, .020 17. .252 19. .307 1. .00 55. .72 1SG1423
ATOM 1423 CB MET 187 107. .525 17. .125 19. .017 1. .00 55. .72 1SG1424
ATOM 1424 CG MET 187 108. .316 18. ,396 19. .335 1. .00 55. .72 1SG1425
ATOM 1425 SD MET 187 107. .891 19. ,829 18. .299 1. .00 55. .72 1SG1426
ATOM 1426 CE MET 187 109. .090 20, .949 19. .077 1 .00 55. .72 1SG1427
ATOM 1427 C MET 187 105. .356 15. .995 18. .849 1, .00 55. .72 1SG1428
ATOM 1428 O MET 187 105. .529 14. .926 19. .429 1. .00 55. .72 1SG1429
ATOM 1429 N VAL 188 104. .520 16. .135 17. .809 1, .00 51 .70 1SG1430
ATOM 1430 CA VAL 188 103. .788 15. .069 17. .192 1 .00 51 .70 1SG1431
ATOM 1431 CB VAL 188 102. .611 15. .589 16. .423 1, .00 51, .70 1SG1432
ATOM 1432 CGI VAL 188 103. .111 16. .634 15. .421 1 , .00 51, .70 1SG1433
ATOM 1433 CG2 VAL 188 101. .880 14. .402 15, .782 1, .00 51, .70 1SG1434
ATOM 1434 C VAL 188 104. .653 14. .243 16 .290 1 .00 51 .70 1SG1435
ATOM 1435 O VAL 188 104. .369 13. .064 16, .084 1, .00 51 .70 1SG1436
ATOM 1436 N SER 189 105. .695 14. .845 15 .676 1 .00 45 .32 1SG1437
ATOM 1437 CA SER 189 106. .516 14. .100 14, .761 1 .00 45 .32 1SG1438
ATOM 1438 CB SER 189 106, .005 14. .172 13 .309 1 .00 45 .32 1SG1439
ATOM 1439 OG SER 189 106, .846 13, .421 12, .443 1 .00 45 .32 1SG1440
ATOM 1440 C SER 189 107. .897 14, .687 14 .787 1 .00 45 .32 1SG1441
ATOM 1441 O SER 189 108. .139 15, .703 15, .435 1 .00 45 .32 1SG1442
ATOM 1442 N VAL 190 108. .848 14, .039 14 .081 1 .00 41 .08 1SG1443
ATOM 1443 CA VAL 190 110 .215 14 .483 14 .047 1 .00 41 .08 1SG1444
ATOM 1444 CB VAL 190 111, .146 13 .496 13 .407 1 .00 41 .08 1SG1445
ATOM 1445 CGI VAL 190 112, .551 14, .118 13. .340 1 . 00 41 .08 1SG1446
ATOM 1446 CG2 VAL 190 111, .082 12. .176 14 .194 1 .00 41 .08 1SG1447
ATOM 1447 C VAL 190 110 .277 15 .744 13 .246 1 .00 41 .08 1SG1448
ATOM 1448 O VAL 190 109 .468 15 .966 12 .346 1 .00 41 .08 1SG1449
ATOM 1449 N PRO 191 111, .225 16, .587 13, .565 1 .00 40 .46 1SG1450
ATOM 1450 CA PRO 191 111, .350 17 .830 12 .861 1 .00 40 .46 1SG1451
ATOM 1451 CD PRO 191 111 .735 16 .681 14 .924 1 .00 40 .46 1SG1452
ATOM 1452 CB PRO 191 112 .371 18 .653 13 .641 1 .00 40 .46 1SG1453
ATOM 1453 CG PRO 191 112, .210 18, .137 15, .084 1, .00 40, .46 1SG1454
ATOM 1454 C PRO 191 111 .698 17 .593 11 .429 1 .00 40 .46 1SG1455
ATOM 1455 O PRO 191 112 .556 16 .759 11 .140 1 .00 40 .46 1SG1456
ATOM 1456 N THR 192 111 .055 18 .339 10 .518 1 .00 41 .29 1SG1457
ATOM 1457 CA THR 192 111 .295 18 .120 9 .125 1 .00 41 .29 1SG1458
ATOM 1458 CB THR 192 110 .037 18 .097 8 .310 1 .00 41 .29 1SG1459
ATOM 1459 OGl THR 192 110 .339 17 .803 6 .955 1 .00 41 .29 1SG1460
ATOM 1460 CG2 THR 192 109 .347 19 .468 8 .422 1 .00 41 .29 1SG1461
ATOM 1461 C THR 192 112 .124 19 .242 8 .609 1 .00 41 .29 1SG1462
ATOM 1462 O THR 192 111 .880 20 .411 8 . 900 1 . 00 41 .29 1SG1463
ATOM 1463 N VAL 193 113, .153 18, .898 7, .817 1 .00 44 .69 1SG1464
ATOM 1464 CA VAL 193 113 .969 19 .920 7 .248 1 .00 44 .69 1SG1465 vD t-~ ∞ cn o H CN ro -φ iιnn vvoo r>~ ccoo ccnn oo HH CCNN rroo '^>j' _ω. vvoo rr^- ccoo ccnn oo HH CN n ^ ιn vo [^ <x3 cn o H CN rθ '* ιn ιo r-- oo σι θ H CN cθ '^ ιn vo r~ co cn o H CN ιø iD io vo r r- r- r- r~ r^ r^ c^ ^ r^ ∞ ∞ ∞ eD CD co cϊi oo co oD cn σi cn cn cn cn cn cri cn cn o o o o o o o o o o H H H H H H H H H H CN CN CN
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ATOM 1522 CDl LEU 200 111,.036 21..076 15..347 1,.00 44..61 1SG1523
ATOM 1523 C LEU 200 106, .732 21. .414 14. .235 1. .00 44. .61 1SG1524
ATOM 1524 O LEU 200 106, .012 22. .410 14, .159 1. .00 44. .61 1SG1525
ATOM 1525 N GLU 201 106. .235 20. .186 14, .477 1. .00 40. .55 1SG1526
ATOM 1526 CA GLU 201 104. .822 19. .992 14, .625 1. .00 40. .55 1SG1527
ATOM 1527 CB GLU 201 104, .304 18. .794 13 .812 1. .00 40. .55 1SG1528
ATOM 1528 CG GLU 201 104, .452 18. .978 12 .300 1. .00 40, .55 1SG1529
ATOM 1529 CD GLU 201 103, .994 17, .694 11 .623 1, .00 40, .55 1SG1530
ATOM 1530 OEl GLU 201 103, .572 16. .759 12 .354 1, .00 40, .55 1SG1531
ATOM 1531 OE2 GLU 201 104, .060 17. .630 10, .366 1. .00 40, .55 1SG1532
ATOM 1532 C GLU 201 104. .545 19. .723 16, .074 1, .00 40. .55 1SG1533
ATOM 1533 O GLU 201 105, .216 18, .908 16 .705 1. .00 40. .55 1SG1534
ATOM 1534 N VAL 202 103 .535 20. .422 16 .634 1. .00 39. .14 1SG1535
ATOM 1535 CA VAL 202 103, .180 20. .291 18 .022 1, .00 39, .14 1SG1536
ATOM 1536 CB VAL 202 103, .398 21. .568 18 .774 1. .00 39, .14 1SG1537
ATOM 1537 CGI VAL 202 102, .822 21. .412 20, .185 1. .00 39, .14 1SG1538
ATOM 1538 CG2 VAL 202 104, .899 21. .904 18, .746 1, .00 39, .14 1SG1539
ATOM 1539 C VAL 202 101, .711 19. .974 18, .096 1. .00 39, .14 1SG1540
ATOM 1540 O VAL 202 100 .959 20. .313 17 .184 1 .00 39 .14 1SG1541
ATOM 1541 N ASN 203 101, .262 19, .285 19 .175 1. .00 40 .28 1SG1542
ATOM 1542 CA ASN 203 99 .867 18, .924 19 .276 1. .00 40 .28 1SG1543
ATOM 1543 CB ASN 203 99, .525 17. .904 20 .376 1. .00 40, .28 1SG1544
ATOM 1544 CG ASN 203 99, .656 18. .564 21 .732 1. .00 40, .28 1SG1545
ATOM 1545 OD1 ASN 203 98, .717 19. .179 22, .234 1. .00 40, .28 1SG1546
ATOM 1546 ND2 ASN 203 100 .853 18. .413 22 .351 1, .00 40 .28 1SG1547
ATOM 1547 C ASN 203 99 .007 20, .145 19 .475 1, .00 40 .28 1SG1548
ATOM 1548 O ASN 203 97, .961 20. .275 18 .842 1, .00 40 .28 1SG1549
ATOM 1549 N ALA 204 99, .441 21. .087 20 .339 1, .00 40, .55 1SG1550
ATOM 1550 CA ALA 204 98, .743 22. .329 20 .576 1, .00 40, .55 1SG1551
ATOM 1551 CB ALA 204 98, .821 23. .287 19, .380 1, .00 40, .55 1SG1552
ATOM 1552 C ALA 204 97, .292 22. .176 20, .930 1. .00 40, .55 1SG1553
ATOM 1553 O ALA 204 96, .417 22, .662 20 .212 1. .00 40 .55 1SG1554
ATOM 1554 N VAL 205 96, .994 21, .502 22 .058 1, .00 44 .37 1SG1555
ATOM 1555 CA VAL 205 95, .633 21, .428 22 .506 1, .00 44, .37 1SG1556
ATOM 1556 CB VAL 205 95. .014 20. .075 22 .317 1, .00 44, .37 1SG1557
ATOM 1557 CGI VAL 205 95, .801 19. .058 23, .162 1, .00 44, .37 1SG1558
ATOM 1558 CG2 VAL 205 93. .524 20. .163 22. .687 1. .00 44, .37 1SG1559
ATOM 1559 C VAL 205 95. .638 21. .706 23 .975 1. .00 44, .37 1SG1560
ATOM 1560 O VAL 205 96, .499 21, .224 24 .708 1. .00 44, .37 1SG1561
ATOM 1561 N LEU 206 94, .671 22, .513 24 .448 1. .00 47, .26 • 1SG1562
ATOM 1562 CA LEU 206 94, .582 22 , .780 25. .851 1. .00 47. .26 1SG1563
ATOM 1563 CB LEU 206 93 , .644 23. .964 26, .155 1. .00 47. .26 1SG1564
ATOM 1564 CG LEU 206 93. .564 24. .383 27, .634 1. .00 47. .26 1SG1565
ATOM 1565 CD2 LEU 206 92. .320 25. .245 27, .902 1. .00 47. .26 1SG1566
ATOM 1566 CDl LEU 206 94. .864 25. .059 28, .097 1. .00 47. .26 1SG1567
ATOM 1567 C LEU 206 93. .965 21. .548 26, .424 1. .00 47, .26 1SG1568
ATOM 1568 O LEU 206 93. .094 20. .950 25, .795 1. .00 47. .26 1SG1569
ATOM 1569 N PHE 207 94. .408 21. .101 27, .614 1. .00 47. .03 1SG1570
ATOM 1570 CA PHE 207 93. .743 19. .953 28. .156 1. .00 47. .03 1SG1571
ATOM 1571 CB PHE 207 94. .462 18. .604 27. .955 1. .00 47. .03 1SG1572
ATOM 1572 CG PHE 207 95. .689 18. .515 28. .791 1. .00 47. .03 1SG1573
ATOM 1573 CDl PHE 207 95. .599 18. .082 30. .093 1. .00 47. .03 1SG1574
ATOM 1574 CD2 PHE 207 96. .921 18. .841 28, .275 1. .00 47. .03 1SG1575
ATOM 1575 CE1 PHE 207 96. .721 17. .981 30, .878 1. .00 47. .03 1SG1576
ATOM 1576 CE2 PHE 207 98. ,048 18. ,744 29. .056 1. ,00 47. .03 1SG1577
ATOM 1577 CZ PHE 207 97. ,946 18. ,313 30. .357 1. 00 47. .03 1SG1578
ATOM 1578 C PHE 207 93. .549 20. .200 29. .615 1. .00 47. .03 1SG1579 ATOM 1579 O PHE 207 94.,123 21..137 30..165 1..00 47..03 1SG1580
ATOM 1580 N LEU 208 92. .685 19. .410 30. .286 1. .00 47. .03 1SG1581
ATOM 1581 CA LEU 208 92. .577 19. .674 31. .689 1. ,00 47. .03 1SG1582
ATOM 1582 CB LEU 208 91. .300 20. .434 32. .135 1. ,00 47. .03 1SG1583
ATOM 1583 CG LEU 208 89. .982 19, .660 32. .292 1. .00 47. ,03 1SG1584
ATOM 1584 CD2 LEU 208 90. .037 18, .732 33. .504 1. .00 47. ,03 1SG1585
ATOM 1585 CDl LEU 208 89. .527 18, .988 30. .993 1. .00 47. ,03 1SG1586
ATOM 1586 C LEU 208 92. .819 18, .407 32. .445 1. .00 47. ,03 1SG1587
ATOM 1587 O LEU 208 92. .512 17, .314 31, .977 1. .00 47. ,03 1SG1588
ATOM 1588 N LEU 209 93. .467 18, .547 33, .618 1. .00 43. ,80 1SG1589
ATOM 1589 CA LEU 209 93. .880 17, .460 34, .459 1. .00 43. .80 1SG1590
ATOM 1590 CB LEU 209 94 , .791 17 .913 35, .613 1. .00 43. .80 1SG1591
ATOM 1591 CG LEU 209 96. .146 18, .474 35, .145 1. .00 43. .80 1SG1592
ATOM 1592 CD2 LEU 209 97. .112 18, .657 36, .326 1. .00 43. .80 1SG1593
ATOM 1593 CDl LEU 209 95. .964 19 .756 34, .318 1. .00 43. .80 1SG1594
ATOM 1594 C LEU 209 92. .714 16 .750 35, .072 1. .00 43. .80 1SG1595
ATOM 1595 O LEU 209 92. .742 15, .530 35, .225 > 1. .00 43. .80 1SG1596
ATOM 1596 N GLY 210 91. .657 17, .490 35, .455 1. .00 41. .19 1SG1597
ATOM 1597 CA GLY 210 90. .579 16 .866 36 .166 1, .00 41, .19 1SG1598
ATOM 1598 C GLY 210 89, .981 15 .760 35 .353 1. .00 41, .19 1SG1599
ATOM 1599 O GLY 210 89. .760 14, .668 35, .875 1. .00 41. .19 1SG1600
ATOM 1600 N LYS 211 89. .689 15, .998 34, .061 1. .00 41. .10 1SG1601
ATOM 1601 CA LYS 211 89. .128 14 .947 33 .267 1. .00 41, .10 1SG1602
ATOM 1602 CB LYS 211 87. .591 14 .885 33 .331 1. .00 41, .10 1SG1603
ATOM 1603 CG LYS 211 86. .990 13, .758 32, .490 1. .00 41. .10 1SG1604
ATOM 1604 CD LYS 211 85. .515 13 .487 32 .794 1. .00 41, .10 1SG1605
ATOM 1605 CE LYS 211 84. .572 14 .572 32 .269 1. .00 41, .10 1SG1606
ATOM 1606 NZ LYS 211 83. .171 14 .231 32 .604 1, .00 41, .10 1SG1607
ATOM 1607 C LYS 211 89, .501 15, .189 31, .841 1. .00 41, .10 1SG1608
ATOM 1608 O LYS 211 89. .321 16 .288 31 .324 1. .00 41, .10 1SG1609
ATOM 1609 N PRO 212 90. .046 14 .199 31 .193 1, .00 40, .68 1SG1610
ATOM 1610 CA PRO 212 90, .385 14 .399 29 .811 1, .00 40, .68 1SG1611
ATOM 1611 CD PRO 212 91. .026 13 .362 31. .868 1. .00 40. .68 1SG1612
ATOM 1612 CB PRO 212 91, .466 13 .372 29 .483 1. .00 40. .68 1SG1613
ATOM 1613 CG PRO 212 92 , .143 13 .118 30 .841 1, .00 40. .68 1SG1614
ATOM 1614 C PRO 212 89, .187 14 .310 28 .919 1. .00 40. .68 1SG1615
ATOM 1615 O PRO 212 88. .324 13 .466 29, .159 1. .00 40. .68 1SG1616
ATOM 1616 N ILE 213 89. .121 15 .168 27 .882 1, .00 40. .33 1SG1617
ATOM 1617 CA ILE 213 88, .053 15 .128 26 .928 1, .00 40, .33 1SG1618
ATOM 1618 CB ILE 213 86, .992 16 .162 27 .169 1. .00 40, .33 1SG1619
ATOM 1619 CG2 ILE 213 87. .632 17, .551 27, .012 1. .00 40. .33 1SG1620
ATOM 1620 CGI ILE 213 85. .784 15 .918 26 .249 1. .00 40. .33 1SG1621
ATOM 1621 CDl ILE 213 84. .555 16 .745 26 .623 1. .00 40. .33 1SG1622
ATOM 1622 C ILE 213 88, .663 15 .426 25 .594 1. .00 40. .33 1SG1623
ATOM 1623 O ILE 213 89, .532 16 .290 25 .481 1. .00 40. .33 1SG1624
ATOM 1624 N ILE 214 88. .210 14, .720 24 .541 1. .00 39. .55 1SG1625
ATOM 1625 CA ILE 214 88, .754 14 .909 23 .227 1. .00 39. .55 1SG1626
ATOM 1626 CB ILE 214 88. .740 13 .664 22 .390 1. .00 39. .55 1SG1627
ATOM 1627 CG2 ILE 214 89, .206 14 .040 20 .974 1. .00 39. .55 1SG1628
ATOM 1628 CGI ILE 214 89, .597 12 .569 23 .049 1. .00 39. .55 1SG1629
ATOM 1629 CDl ILE 214 91, .064 12 .963 23 .213 1. .00 39. .55 1SG1630
ATOM 1630 C ILE 214 87, .924 15 .934 22 .521 1. .00 39. .55 1SG1631
ATOM 1631 O ILE 214 86, .703 15 .964 22 .661 1, .00 39. .55 1SG1632
ATOM 1632 N LEU 215 88. .592 16. .826 21, .761 1. .00 37. .89 1SG1633
ATOM 1633 CA LEU 215 87. .926 17. .880 21 .051 1. .00 37. .89 1SG1634
ATOM 1634 CB LEU 215 88. .930 18 .935 20 .530 1. .00 37. .89 1SG1635
ATOM 1635 CG LEU 215 88. .359 20 .294 20 .067 1. .00 37. .89 1SG1636 ATOM 1636 CD2 LEU 215 87..246 20..164 19..019 1.,00 37.,89 1SG1637
ATOM 1637 CDl LEU 215 89. .489 21. .216 19. .583 1. ,00 37. ,89 1SG1638
ATOM 1638 C LEU 215 87. .193 17. ,246 19. ,903 1. ,00 37. ,89 1SG1639
ATOM 1639 O LEU 215 87. .670 16. .300 19. .277 1. ,00 37. ,89 1SG1640
ATOM 1640 N PRO 216 86, .023 17. .750 19. .637 1. .00 35. .35 1SG1641
ATOM 1641 CA PRO 216 85. .167 17. .231 18. .606 1. .00 35. .35 1SG1642
ATOM 1642 CD PRO 216 85, .284 18. .507 20. .633 1. .00 35. .35 1SG1643
ATOM 1643 CB PRO 216 83, .781 17. .834 18, .864 1. .00 35. .35 1SG1644
ATOM 1644 CG PRO 216 84 .022 18. .960 19. .886 1. .00 35. .35 1SG1645
ATOM 1645 C PRO 216 85. .661 17. .445 17. .209 1. .00 35. .35 1SG1646
ATOM 1646 O PRO 216 85. .097 16, .843 16, .298 1. ,00 35. .35 1SG1647
ATOM 1647 N THR 217 86, .680 18, .293 16, .987 1. .00 32. .87 1SG1648
ATOM 1648 CA THR 217 87. .077 18. .530 15. .629 1. .00 32. ,87 1SG1649
ATOM 1649 CB THR 217 86. .838 19. .941 15. .178 1. .00 32. .87 1SG1650
ATOM 1650 OGl THR 217 87. .030 20. .051 13. .776 1. .00 32 , .87 1SG1651
ATOM 1651 CG2 THR 217 87, .811 20. .869 15. .925 1. .00 32. .87 1SG1652
ATOM 1652 C THR 217 88, .538 18, .246 15. .475 1. .00 32. .87 1SG1653
ATOM 1653 O THR 217 89, .223 17, .895 16, .434 1. .00 32 .87 1SG1654
ATOM 1654 N ASP 218 89. .035 18. .356 14, .223 1. .00 31. .17 1SG1655
ATOM 1655 CA ASP 218 90. .415 18 , .110 13, .914 1. .00 31 .17 1SG1656
ATOM 1656 CB ASP 218 90. .622 17, .130 1 .747 1. .00 31. .17 1SG1657
ATOM 1657 CG ASP 218 90 .047 17 , .763 11 .487 1, .00 31 .17 1SG1658
ATOM 1658 OD1 ASP 218 89. .117 18. .603 11, .614 1, .00 31. .17 1SG1659
ATOM 1659 OD2 ASP 218 90, .532 17. .413 10. .377 1, .00 31. .17 1SG1660
ATOM 1660 C ASP 218 91, .043 19. .410 13 .513 1, .00 31 .17 1SG1661
ATOM 1661 O ASP 218 90. .361 20, .331 13. .069 1. .00 31. .17 1SG1662
ATOM 1662 N ALA 219 92. .379 19. .511 13. .678 1. .00 30 .50 1SG1663
ATOM 1663 CA ALA 219 93. .105 20, .704 13 .340 1, .00 30. .50 1SG1664
ATOM 1664 CB ALA 219 94. .563 20. .698 13. .829 1. .00 30 .50 1SG1665
ATOM 1665 C ALA 219 93, .150 20. .829 11 .852 1. .00 30, .50 1SG1666
ATOM 1666 O ALA 219 93 .102 19, .833 11 .132 1 .00 30 .50 1SG1667
ATOM 1667 N THR 220 93, .234 22. .077 11. .350 1. .00 32, .44 1SG1668
ATOM 1668 CA THR 220 93 .286 22. .277 9. .931 1. .00 32 .44 1SG1669
ATOM 1669 CB THR 220 92, .784 23. .622 9 .497 1 .00 32 .44 1SG1670
ATOM 1670 OGl THR 220 91 .437 23. .801 9, .912 1, .00 32 .44 1SG1671
ATOM 1671 CG2 THR 220 92, .880 23. .711 7 .964 1, .00 32, .44 1SG1672
ATOM 1672 C THR 220 94 .711 22. .167 9. .500 1, .00 32 .44 1SG1673
ATOM 1673 O THR 220 95 .631 22. .325 10 .300 1 .00 32 .44 1SG1674
ATOM 1674 N PRO 221 94, .931 21. .844 8, .256 1, .00 36, .58 1SG1675
ATOM 1675 CA PRO 221 96, .288 21, .823 7, .799 1, .00 36 .58 1SG1676
ATOM 1676 CD PRO 221 94, .112 20 .854 7. .577 1, .00 36 .58 1SG1677
ATOM 1677 CB PRO 221 96, .279 21. .053 6, .482 1, .00 36, .58 1SG1678
ATOM 1678 CG PRO 221 95, .075 20. .104 6 .638 1. .00 36, .58 1SG1679
ATOM 1679 C PRO 221 96 .721 23. .243 7, .696 1, .00 36 .58 1SG1680
ATOM 1680 O PRO 221 95, .977 24. .040 7, .126 1, .00 36. .58 1SG1681
ATOM 1681 N PHE 222 97 .910 23. .598 8, .212 1. .00 4 .23 1SG1682
ATOM 1682 CA PHE 222 98, .235 24, .984 8 .111 1, .00 43, .23 1SG1683
ATOM 1683 CB PHE 222 98, .562 25. .645 9, .458 1. .00 43, .23 1SG1684
ATOM 1684 CG PHE 222 97, .314 25. .507 10 .254 1. .00 43, .23 1SG1685
ATOM 1685 CDl PHE 222 96, .220 26 .283 9. .958 1. .00 43. .23 1SG1686
ATOM 1686 CD2 PHE 222 97 .221 24. .574 11, .261 1 .00 43 .23 1SG1687
ATOM 1687 CE1 PHE 222 95. .054 26, .156 10, .672 1. .00 43, .23 1SG1688
ATOM 1688 CE2 PHE 222 96, .059 24, .445 11, .982 1 .00 43, .23 1SG1689
ATOM 1689 CZ PHE 222 94, .976 25, .237 11 .687 1, .00 43, .23 1SG1690
ATOM 1690 C PHE 222 99, .405 25. .147 7, .208 1, .00 43, .23 1SG1691
ATOM 1691 O PHE 222 100, .522 24. .746 7, .533 1, .00 43, .23 1SG1692
ATOM 1692 N VAL 223 99, .160 25. .760 6, .035 1, .00 51 .72 1SG1693 ATOM 1693 CA VAL 223 100.220 26..032 5,.117 1..00 51..72 1SG1694
ATOM 1694 CB VAL 223 99 .927 25, .595 3. .708 1. .00 51. .72 1SG1695
ATOM 1695 CGI VAL 223 98 .631 26, .266 3, .220 1. .00 51. .72 1SG1696
ATOM 1696 CG2 VAL 223 101. .155 25. .917 2 .840 1, .00 51. .72 1SG1697
ATOM 1697 C VAL 223 100 .398 27. .514 5, .141 1. .00 51. .72 1SG1698
ATOM 1698 O VAL 223 99 .462 28, .271 4 .890 1, .00 51. .72 1SG1699
ATOM 1699 N LEU 224 101 .618 27, .972 5. .467 1. .00 61. .53 1SG1700
ATOM 1700 CA LEU 224 101 .840 29, .382 5 .570 1. .00 61. .53 1SG1701
ATOM 1701 CB LEU 224 102 .605 29, .754 6. .859 1, .00 61. .53 1SG1702
ATOM 1702 CG LEU 224 102. .701 31. .256 7. .208 1. .00 61. .53 1SG1703
ATOM 1703 CD2 LEU 224 103 .274 32. .104 6. .064 1. .00 61. .53 1SG1704
ATOM 1704 CDl LEU 224 103 .492 31. .454 8 .511 1 .00 61. .53 1SG1705
ATOM 1705 C LEU 224 10 .644 29, .772 4, .377 1. .00 61. .53 1SG1706
ATOM 1706 O LEU 224 103. .597 29. .109 3. .973 1. .00 61. .53 1SG1707
ATOM 1707 N PRO 225 102 .211 30. .857 3. .816 1, .00 70, .45 1SG1708
ATOM 1708 CA PRO 225 102 .765 31. .341 2 .582 1 .00 70, .45 1SG1709
ATOM 1709 CD PRO 225 100 .801 31. .187 3. .939 1, .00 70 .45 1SG1710
ATOM 1710 CB PRO 225 101. .620 32. .050 1. .852 1, .00 70. .45 1SG1711
ATOM 1711 CG PRO 225 100 .573 32. .326 2, .940 1. .00 70, .45 1SG1712
ATOM 1712 C PRO 225 103 .997 32. .181 2. .599 1 .00 70 .45 1SG1713
ATOM 1713 O PRO 225 104 .517 32. .538 3 .659 1 .00 70 .45 1SG1714
ATOM 1714 N ARG 226 104. .452 32. .457 1. .359 1, .00 71, .72 1SG1715
ATOM 1715 CA ARG 226 105. .551 33. .274 0. .947 1, .00 71, .72 1SG1716
ATOM 1716 CB ARG 226 106 .433 33. .837 2 .067 1 .00 71 .72 1SG1717
ATOM 1717 CG ARG 226 107, .338 34. .963 1, .561 1, .00 71, .72 1SG1718
ATOM 1718 CD ARG 226 108, .403 35. .421 2. .557 1, .00 71, .72 1SG1719
ATOM 1719 NE ARG 226 109 .644 34. .656 2. .253 1, .00 71, .72 1SG1720
ATOM 1720 CZ ARG 226 110 .495 35. .104 1 .285 1, .00 71 .72 1SG1721
ATOM 1721 NHl ARG 226 110 .208 36, .250 0, .602 1, .00 71, .72 1SG1722
ATOM 1722 NH2 ARG 226 111, .632 34. .406 0. .998 1. .00 71. .72 1SG1723
ATOM 1723 C ARG 226 106 .368 32. .366 0, .101 1, .00 71. .72 1SG1724
ATOM 1724 O ARG 226 105 .952 31, .233 -0 .136 1, .00 71 .72 1SG1725
ATOM 1725 N HIS 227 107 .527 32, .822 -0. .411 1, .00 67. .74 1SG1726
ATOM 1726 CA HIS 227 108, .303 31. .852 -1. .123 1. .00 67. .74 1SG1727
ATOM 1727 NDl HIS 227 110 .183 31. .105 -3, .829 1. .00 67, .74 1SG1728
ATOM 1728 CG HIS 227 110 .378 31. .386 -2 .495 1 .00 67 .74 1SG1729
ATOM 1729 CB HIS 227 109 .600 32. .414 -1. .729 1. .00 67, .74 1SG1730
ATOM 1730 NE2 HIS 227 111, .809 29. , 759 -3. .128 1. .00 67. .74 1SG1731
ATOM 1731 CD2 HIS 227 111, .374 30. .555 -2, .083 1. .00 67. .74 1SG1732
ATOM 1732 CE1 HIS 227 111, .065 30. .126 -4. .156 1. .00 67. .74 1SG1733
ATOM 1733 C HIS 227 108 .672 30. ,888 -0. .052 1. .00 67. .74 1SG1734
ATOM 1734 O HIS 227 109, .515 31. .211 0. .784 1. .00 67, .74 1SG1735
ATOM 1735 N VAL 228 108, .053 29. .682 -0. .111 1. .00 60. .07 1SG1736
ATOM 1736 CA VAL 228 108, .033 28. ,642 0. .886 1. .00 60. ,07 1SG1737
ATOM 1737 CB VAL 228 108, .884 27. .453 0. .531 1. .00 60. .07 1SG1738
ATOM 1738 CGI VAL 228 110. .328 27. .917 0. .283 1. .00 60. .07 1SG1739
ATOM 1739 CG2 VAL 228 108, .749 26. ,407 1. .650 1. .00 60. .07 1SG1740
ATOM 1740 C VAL 228 108, .430 29. .193 2. .217 1. .00 60. .07 1SG1741
ATOM 1741 0 VAL 228 109, .609 29. .257 2. .564 1. .00 60. .07 1SG1742
ATOM 1742 N GLY 229 107 .418 29. .630 2. .995 1. .00 51. .66 1SG1743
ATOM 1743 CA GLY 229 107, .674 30. .214 4. .277 1. .00 51. .66 1SG1744
ATOM 1744 C GLY 229 108, .184 31. ,591 4. ,016 1. .00 51. .66 1SG1745
ATOM 1745 O GLY 229 108. .304 32. ,004 2. ,865 1. ,00 51. ,66 1SG1746
ATOM 1746 N THR 230 108 .513 32. .344 5. .083 1. .00 48. .80 1SG1747
ATOM 1747 CA THR 230 108. .980 33. .682 4. .867 1. .00 48. .80 1SG1748
ATOM 1748 CB THR 230 108. .083 34. .726 5. .465 1. 00 48. .80 1SG1749
ATOM 1749 OGl THR 230 108, .072 34. .601 6. ,880 1. ,00 48. ,80 1SG1750 ATOM 1750 CG2 THR 230 106,.660 34 ,.541 4..917 1..00 48..80 1SG1751
ATOM 1751 C THR 230 110, .291 33. .846 5. .561 1. .00 48, .80 1SG1752
ATOM 1752 O THR 230 110, .526 33. .251 6, .611 1. .00 48. .80 1SG1753
ATOM 1753 N GLU 231 111, .201 34. .639 4. .957 1. .00 47. .56 1SG1754
ATOM 1754 CA GLU 231 112, .431 34. .965 5. .615 1. .00 47. .56 1SG1755
ATOM 1755 CB GLU 231 113, .396 35. .759 4. .718 1. .00 47. .56 1SG1756
ATOM 1756 CG GLU 231 113, .994 34. .942 3. .570 1. .00 47, .56 1SG1757
ATOM 1757 CD GLU 231 115, .142 34. .111 4. .126 1. .00 47, .56 1SG1758
ATOM 1758 OEl GLU 231 115, .431 34, .244 5. .345 1, .00 47, .56 1SG1759
ATOM 1759 OE2 GLU 231 115, .748 33, .336 3. .339 1. .00 47, .56 1SG1760
ATOM 1760 C GLU 231 112, .041 35, .851 6, .746 1, .00 47, .56 1SG1761
ATOM 1761 O GLU 231 112, .496 35, .654 7, .866 1. .00 47, .56 1SG1762
ATOM 1762 N GLY 232 111, .197 36, .862 6. .437 1. .00 45, .45 1SG1763
ATOM 1763 CA GLY 232 110, .526 37. .776 7. .328 1. .00 45, .45 1SG1764
ATOM 1764 C GLY 232 111, .238 37. .935 8. .631 1, .00 45, .45 1SG1765
ATOM 1765 O GLY 232 112 .119 38. .778 8. .802 1, .00 45 .45 1SG1766
ATOM 1766 N SER 233 110 .810 37. .102 9. .601 1, .00 44 .01 1SG1767
ATOM 1767 CA SER 233 111 .325 37. .086 10, .935 1 .00 44 .01 1SG1768
ATOM 1768 CB SER 233 110, .246 37. .300 12, .011 1, .00 44 .01 1SG1769
ATOM 1769 OG SER 233 109, .681 38, .596 11. .881 1, .00 44 .01 1SG1770
ATOM 1770 C SER 233 111, .917 35, .731 11. .157 1, .00 44 .01 1SG1771
ATOM 1771 O SER 233 111, .909 34. .883 10. .265 1, .00 44. .01 1SG1772
ATOM 1772 N MET 234 112, .513 35. .525 12. .346 1, .00 41, .84 1SG1773
ATOM 1773 CA MET 234 113 .171 34. .285 12. .644 1 .00 41 .84 1SG1774
ATOM 1774 CB MET 234 113 .923 34. .333 13, .984 1 .00 41 .84 1SG1775
ATOM 1775 CG MET 234 115 .090 35. .320 13, .985 1 .00 41 .84 1SG1776
ATOM 1776 SD MET 234 116 .002 35. .406 15, .555 1, .00 41 .84 1SG1777
ATOM 1777 CE MET 234 117, .185 36. .658 14, .981 1, .00 41 .84 1SG1778
ATOM 1778 C MET 234 112, .219 33, .127 12, .718 1, .00 41 .84 1SG1779
ATOM 1779 O MET 234 112, .449 32. .096 12. .087 1, .00 41 .84 1SG1780
ATOM 1780 N ALA 235 111 .105 33 .256 13 .467 1 .00 40 .52 1SG1781
ATOM 1781 CA ALA 235 110 .269 32 .100 13. .622 1 .00 40 .52 1SG1782
ATOM 1782 CB ALA 235 110 .324 31. .489 15. .032 1 .00 40 .52 1SG1783
ATOM 1783 C ALA 235 108 .851 32 .472 13. .363 1 .00 40 .52 1SG1784
ATOM 1784 O ALA 235 108 .470 33. .635 13. .476 1, .00 40 .52 1SG1785
ATOM 1785 N THR 236 108 .035 31, .471 12. .973 1 .00 43 .22 1SG1786
ATOM 1786 CA THR 236 106, .649 31, .730 12. .732 1, .00 43 .22 1SG1787
ATOM 1787 CB THR 236 106, .288 31. .757 11. .275 1, .00 43, .22 1SG1788
ATOM 1788 OGl THR 236 104 .948 32 .198 11, .109 1 .00 43 .22 1SG1789
ATOM 1789 CG2 THR 236 106 .459 30 .343 10, .694 1 .00 43 .22 1SG1790
ATOM 1790 C THR 236 105 .861 30. .629 13 , .363 1 .00 43 .22 1SG1791
ATOM 1791 O THR 236 106 .238 29. .460 13, .285 1 .00 43 .22 1SG1792
ATOM 1792 N VAL 237 104, .735 30. .971 14 , .021 1, .00 45, .38 1SG1793
ATOM 1793 CA VAL 237 103, .963 29, .899 14. .569 1, .00 45, .38 1SG1794
ATOM 1794 CB VAL 237 103, .832 29, .869 16. .066 1, .00 45, .38 1SG1795
ATOM 1795 CGI VAL 237 102, .652 30. .751 16. .488 1, .00 45, .38 1SG1796
ATOM 1796 CG2 VAL 237 103 .685 28. .404 16, .506 1 .00 45 .38 1SG1797
ATOM 1797 C VAL 237 102 .593 30. .010 14 , .005 1 .00 45 .38 1SG1798
ATOM 1798 O VAL 237 102, .094 31, .106 13, .749 1, .00 45, .38 1SG1799
ATOM 1799 N GLY 238 101, .957 28, .849 13 , .774 1, .00 45, .28 1SG1800
ATOM 1800 CA GLY 238 100, .627 28, .857 13. .258 1. .00 45, .28 1SG1801
ATOM 1801 C GLY 238 99, .764 28, .376 14. .368 1. .00 45, .28 1SG1802
ATOM 1802 O GLY 238 99, .829 27. .213 14. .765 1, .00 45, .28 1SG1803
ATOM 1803 N LEU 239 98 .917 29. .276 14, .899 1, .00 45 .87 1SG1804
ATOM 1804 CA LEU 239 98, .082 28. .856 15, .976 1, .00 45 .87 1SG1805
ATOM 1805 CB LEU 239 97, .943 29, .900 17. .094 1, .00 45, .87 1SG1806
ATOM 1806 CG LEU 239 99, .309 30, .429 17. .566 1, .00 45, .87 1SG1807 ATOM 1807 CD2 LEU 239 99.301 30.814 19.044 1.00 45.87 1SG1808
ATOM 1808 CDl LEU 239 99.818 31.547 16.645 1.00 45.87 1SG1809
ATOM 1809 C LEU 239 96.736 28.604 15.389 1.00 45.87 1SG1810
ATOM 1810 O LEU 239 96.021 29.523 14.995 1.00 45.87 1SG1811
ATOM 1811 N SER 240 96.367 27.318 15.332 1.00 42.90 1SG1812
ATOM 1812 CA SER 240 95.151 26.867 14.728 1.00 42.90 1SG1813
ATOM 1813 CB SER 240 95.101 25.335 14.628 1.00 42.90 1SG1814
ATOM 1814 OG SER 240 93.819 24.912 14.196 1.00 42.90 1SG1815
ATOM 1815 C SER 240 93.977 27.277 15.550 00 42.90 1SG1816
ATOM 1816 0 SER 240 94.088 27.585 16.734 00 42.90 1SG1817
ATOM 1817 N GLN 241 92.802 27.280 14.894 00 40.93 1SG1818
ATOM 1818 CA GLN 241 91.552 27.601 15.507 00 40.93 1SG1819
ATOM 1819 CB GLN 241 90.386 27.577 14.505 00 40.93 1SG1820
ATOM 1820 CG GLN 241 90.503 28.632 13.402 00 40.93 1SG1821
ATOM 1821 CD GLN 241 89.294 28.493 12.488 00 40.93 1SG1822
ATOM 1822 OEl GLN 241 88.496 27.568 12.633 00 40.93 1SG1823
ATOM 1823 NE2 GLN 241 89.155 29.432 11.514 00 40.93 1SG1824
ATOM 1824 C GLN 241 91.292 26.542 16.527 00 40.93 1SG1825
ATOM 1825 O GLN 241 90.741 26.814 17.592 00 40.93 1SG1826
ATOM 1826 N GLN 242 91.695 25.292 16.221 00 41.37 1SG1827
ATOM 1827 CA GLN 242 91.436 24.214 17.128 1.00 41.37 1SG1828
ATOM 1828 CB GLN 242 91.950 22.840 16.672 00 41.37 1SG1829
ATOM 1829 CG GLN 242 93.472 22.710 16.669 00 41.37 1SG1830
ATOM 1830 CD GLN 242 93.781 21.221 16.621 00 41.37 1SG1831
ATOM 1831 OEl GLN 242 93.008 20.435 16.076 00 41.37 1SG1832
ATOM 1832 NE2 GLN 242 94.933 20.816 17.220 00 41.37 1SG1833
ATOM 1833 C GLN 242 92.142 24.515 18.408 00 41.37 1SG1834
ATOM 1834 O GLN 242 91.611 24.266 19.489 00 41.37 1SG1835
ATOM 1835 N LEU 243 93.361 25.076 18.323 1.00 41.15 1SG1836
ATOM 1836 CA LEU 243 94.115 25.325 19.514 1.00 41.15 1SG1837
ATOM 1837 CB LEU 243 95.472 25.991 19.197 1.00 41.15 1SG1838
ATOM 1838 CG LEU 243 96.482 26.122 20.365 1.00 41.15 1SG1839
ATOM 1839 CD2 LEU 243 95.908 26.831 21.603 1.00 41.15 1SG1840
ATOM 1840 CDl LEU 243 97.771 26.802 19.879 1.00 41.15 1SG1841
ATOM 1841 C LEU 243 93.309 26.245 20.377 1.00 41.15 1SG1842
ATOM 1842 O LEU 243 93.133 25.993 21.569 1.00 41.15 1SG1843
ATOM 1843 N PHE 244 92.781 27.334 19.790 1.00 41.27 1SG1844
ATOM 1844 CA PHE 244 92.040 28.310 20.538 1.00 41.27 1SG1845
ATOM 1845 CB PHE 244 91.680 29.553 19.705 1.00 41.27 1SG1846
ATOM 1846 CG PHE 244 92.949 30.270 19.389 1.00 41.27 1SG1847
ATOM 1847 CDl PHE 244 93.676 29.960 18.262 1.00 41.27 1SG1848
ATOM 1848 CD2 PHE 244 93.420 31.253 20.227 1.00 41.27 1SG1849
ATOM 1849 CE1 PHE 244 94.846 30.625 17.976 00 41.27 1SG1850
ATOM 1850 CE2 PHE 244 94.589 31.920 19.945 00 41.27 1SG1851
ATOM 1851 CZ PHE 244 95.306 31.608 18.816 00 41.27 1SG1852
ATOM 1852 C PHE 244 90.765 27.721 21.056 00 41.27 1SG1853
ATOM 1853 O PHE 244 90.386 27.960 22.200 00 41.27 1SG1854
ATOM 1854 N ASP 245 90.063 26.940 20.216 00 39.28 1SG1855
ATOM 1855 CA ASP 245 88.783 26.389 20.563 00 39.28 1SG1856
ATOM 1856 CB ASP 245 88.139 25.627 19.392 00 39.28 1SG1857
ATOM 1857 CG ASP 245 87.731 26.654 18.344 00 39.28 1SG1858
ATOM 1858 OD1 ASP 245 87.037 27.638 18.717 1.00 39.28 1SG1859
ATOM 1859 OD2 ASP 245 88.120 26.477 17.159 1.00 39.28 1SG1860
ATOM 1860 C ASP 245 88.917 25.441 21.712 1.00 39.28 1SG1861
ATOM 1861 0 ASP 245 88.029 25.358 22.558 1.00 39.28 1SG1862
ATOM 1862 N SER 246 90.031 24.696 21.775 1.00 36.54 1SG1863
ATOM 1863 CA SER 246 90.218 23.731 22.817 1.00 36.54 1SG1864 ATOM 1864 CB SER 246 91,.576 23..028 22..700 1..00 36..54 1SG1865
ATOM 1865 OG SER 246 91, .756 22. .156 23. .801 1. .00 36. .54 1SG1866
ATOM 1866 C SER 246 90 .191 24. .430 24. .137 1. .00 36, .54 1SG1867
ATOM 1867 O SER 246 89. .736 23. .874 25. .136 1. .00 36, .54 1SG1868
ATOM 1868 N ALA 247 90. .696 25. .674 24. .182 1. .00 33. .24 1SG1869
ATOM 1869 CA ALA 247 90 .728 26. .389 25. .423 1. .00 33. .24 1SG1870
ATOM 1870 CB ALA 247 91 .396 27, .768 25. .295 1. .00 33, .24 1SG1871
ATOM 1871 C ALA 247 89 .330 26, .615 25. .904 1. .00 33 , .24 1SG1872
ATOM 1872 O ALA 247 89 .022 26, .397 27. .073 1. .00 33. .24 1SG1873
ATOM 1873 N LEU 248 88 .431 27, .037 25. .000 1. .00 32. .23 1SG1874
ATOM 1874 CA LEU 248 87 .092 27, .369 25. .388 1. .00 32. .23 1SG1875
ATOM 1875 CB LEU 248 86 .294 28, .007 24, .233 1. .00 32. .23 1SG1876
ATOM 1876 CG LEU 248 86, .844 29, .399 23. .839 1. .00 32. .23 1SG1877
ATOM 1877 CD2 LEU 248 85 .937 30, .123 22. .831 1. .00 32, .23 1SG1878
ATOM 1878 CDl LEU 248 88 .294 29, .317 23. .342 1. .00 32, .23 1SG1879
ATOM 1879 C LEU 248 86 .394 26, .149 25, .905 1. .00 32, .23 1SG1880
ATOM 1880 O LEU 248 85 .641 26, .225 26. .875 1. .00 32, .23 1SG1881
ATOM 1881 N LEU 249 86 .629 24, .988 25. .269 1. .00 33, .42 1SG1882
ATOM 1882 CA LEU 249 85, .974 23, .772 25, .654 1, .00 33, .42 1SG1883
ATOM 1883 CB LEU 249 86 .335 22, .610 24, .711 1. .00 33, .42 1SG1884
ATOM 1884 CG LEU 249 85 .498 21, .339 24. .930 1. .00 33, .42 1SG1885
ATOM 1885 CD2 LEU 249 86, .126 20, .123 24. .229 1. .00 33, .42 1SG1886
ATOM 1886 CDl LEU 249 84, .037 21, .576 24, .516 1. .00 33, .42 1SG1887
ATOM 1887 C LEU 249 86 .417 23, .386 27, .034 1, .00 33, .42 1SG1888
ATOM 1888 O LEU 249 85, .611 22, .982 27, .870 1. .00 33, .42 1SG1889
ATOM 1889 N LEU 250 87 .728 23, .511 27, .299 1. .00 36, .21 1SG1890
ATOM 1890 CA LEU 250 88 .322 23, .074 28, .528 1. .00 36, .21 1SG1891
ATOM 1891 CB LEU 250 89 .844 23, .274 28, .486 1. .00 36, .21 1SG1892
ATOM 1892 CG LEU 250 90 .608 22. .410 29, .494 1. .00 36, .21 1SG1893
ATOM 1893 CD2 LEU 250 92 .055 22. .874 29, .668 1. .00 36, .21 1SG1894
ATOM 1894 CDl LEU 250 90, .541 20, .943 29, .056 1. .00 36 .21 1SG1895
ATOM 1895 C LEU 250 87, .771 23. .881 29, .670 1. .00 36, .21 1SG1896
ATOM 1896 O LEU 250 87, .434 23. .335 30, .719 1. .00 36, .21 1SG1897
ATOM 1897 N LEU 251 87 .674 25. .213 29, .495 1, .00 39, .19 1SG1898
ATOM 1898 CA LEU 251 87, .175 26. .085 30, .525 1, .00 39, .19 1SG1899
ATOM 1899 CB LEU 251 87 .333 27. .582 30, .194 1, .00 39, .19 1SG1900
ATOM 1900 CG LEU 251 88 .767 28. .118 30, .367 1. .00 39, .19 1SG1901
ATOM 1901 CD2 LEU 251 89, .783 27. .324 29. .535 1. .00 39, .19 1SG1902
ATOM 1902 CDl LEU 251 89, .156 28. .175 31, .852 1. .00 39. .19 1SG1903
ATOM 1903 C LEU 251 85, .719 25. .828 30, .786 1, .00 39. .19 1SG1904
ATOM 1904 O LEU 251 85, .275 25. .892 31, .931 1. .00 39. .19 1SG1905
ATOM 1905 N GLN 252 84, .929 25. .564 29. .727 1. .00 39. .85 1SG1906
ATOM 1906 CA GLN 252 83, .510 25. .354 29. .856 1. .00 39. .85 1SG1907
ATOM 1907 CB GLN 252 82, .851 25. .165 28. .475 1. .00 39. .85 1SG1908
ATOM 1908 CG GLN 252 81, .476 24. .490 28. .486 1. .00 39. .85 1SG1909
ATOM 1909 CD GLN 252 80, .492 25. .328 29. .275 1. .00 39. .85 1SG1910
ATOM 1910 OEl GLN 252 80, .724 25. .632 30. .443 1. .00 39. .85 1SG1911
ATOM 1911 NE2 GLN 252 79, .357 25. .703 28. .628 1. .00 39. .85 1SG1912
ATOM 1912 C GLN 252 83, .202 24. .131 30. .668 1. ,00 39. .85 1SG1913
ATOM 1913 O GLN 252 82, .439 24. .191 31. .631 1. ,00 39. .85 1SG1914
ATOM 1914 N LYS 253 83 , .831 22. .992 30. .333 1. ,00 38. .74 1SG1915
ATOM 1915 CA LYS 253 83, .534 21. .748 30. .989 1. ,00 38. .74 1SG1916
ATOM 1916 CB LYS 253 84, .305 20. .547 30. .414 1. .00 38. .74 1SG1917
ATOM 1917 CG LYS 253 83, .636 19. ,929 29. .185 1. .00 38. .74 1SG1918
ATOM 1918 CD LYS 253 83. .580 20. ,847 27. .966 1. ,00 38. .74 1SG1919
ATOM 1919 CE LYS 253 82. .748 20. .267 26. .820 1. ,00 38. ,74 1SG1920
ATOM 1920 NZ LYS 253 81. .305 20. .423 27. .110 1. ,00 38. ,74 1SG1921 ATOM 1921 C LYS 253 83..860 21.,847 32.,441 1.,00 38.,74 1SG1922
ATOM 1922 O LYS 253 83. .238 21. ,183 33. .269 1. ,00 38. ,74 1SG1923
ATOM 1923 N ALA 254 84. ,866 22 , ,663 32. ,784 1. 00 36. ,58 1SG1924
ATOM 1924 CA ALA 254 85. .283 22. 828 34. ,144 1. ,00 36. 58 1SG1925
ATOM 1925 CB ALA 254 86. .474 23. .792 34. .289 1. ,00 36. ,58 1SG1926
ATOM 1926 C ALA 254 84. .135 23. ,385 34. .929 1. .00 36. .58 1SG1927
ATOM 1927 O ALA 254 83. .967 23. ,052 36. .100 1. 00 36. .58 1SG1928
ATOM 1928 N GLY 255 83. .313 24. ,255 34. .310 1. ,00 35. ,14 1SG1929
ATOM 1929 CA GLY 255 82. .203 24. .832 35. .017 1. ,00 35. .14 1SG1930
ATOM 1930 C GLY 255 82. .641 26. ,159 35. .547 1. .00 35. .14 1SG1931
ATOM 1931 O GLY 255 81. .966 26. ,768 36. .374 1. .00 35. .14 1SG1932
ATOM 1932 N ALA 256 83. .828 26. .602 35. .097 1. .00 36. .55 1SG1933
ATOM 1933 CA ALA 256 84. .436 27. .846 35. .472 1. .00 36. ,55 1SG1934
ATOM 1934 CB ALA 256 85. .892 27. .959 34. .989 1. .00 36. .55 1SG1935
ATOM 1935 C ALA 256 83. .700 29. .034 34, .934 1, .00 36. .55 1SG1936
ATOM 1936 O ALA 256 83. .600 30. ,047 35. .623 1. .00 36. .55 1SG1937
ATOM 1937 N LEU 257 83. .182 28. .974 33. .689 1. .00 38. .34 1SG1938
ATOM 1938 CA LEU 257 82, .617 30. .183 33, .160 1. .00 38. .34 1SG1939
ATOM 1939 CB LEU 257 82, .489 30. .196 31 .629 1. .00 38. .34 1SG1940
ATOM 1940 CG LEU 257 83, .844 30, .076 30. .909 1. .00 38, .34 1SG1941
ATOM 1941 CD2 LEU 257 83. .747 30. .539 29. .451 1. .00 38. .34 1SG1942
ATOM 1942 CDl LEU 257 84, .435 28, .665 31. .057 1. .00 38 .34 1SG1943
ATOM 1943 C LEU 257 81, .258 30, .407 33 .736 1. .00 38. .34 1SG1944
ATOM 1944 O LEU 257 80, .239 30, .141 33. .100 1. .00 38, .34 1SG1945
ATOM 1945 N ASN 258 81, .233 30, .953 34 .965 1. .00 38, .66 1SG1946
ATOM 1946 CA ASN 258 80, .017 31. .274 35. .646 1. .00 38 .66 1SG1947
ATOM 1947 CB ASN 258 79, .646 30, .278 36 .761 1 .00 38 .66 1SG1948
ATOM 1948 CG ASN 258 79, .338 28, .914 36. .158 1, .00 38, .66 1SG1949
ATOM 1949 OD1 ASN 258 79, .198 28. .754 34 .947 1, .00 38, .66 1SG1950
ATOM 1950 ND2 ASN 258 79 .211 27, .886 37, .039 1. .00 38, .66 1SG1951
ATOM 1951 C ASN 258 80 .281 32, .570 36 .345 1 .00 38 .66 1SG1952
ATOM 1952 O ASN 258 81. .401 32, .822 36, .787 1. .00 38, .66 1SG1953
ATOM 1953 N LEU 259 79. .262 33 , .440 36, .447 1. .00 39, .00 1SG1954
ATOM 1954 CA LEU 259 79. .467 34 .665 37 .164 1, .00 39, .00 1SG1955
ATOM 1955 CB LEU 259 79 .810 35, .871 36 .269 1 .00 39 .00 1SG1956
ATOM 1956 CG LEU 259 81. .192 35, .777 35, .594 1. .00 39, .00 1SG1957
ATOM 1957 CD2 LEU 259 82, .300 35, .525 36, .631 1, .00 39, .00 1SG1958
ATOM 1958 CDl LEU 259 81, .476 37 .009 34 .720 1, .00 39, .00 1SG1959
ATOM 1959 C LEU 259 78 .200 34 .991 37. .882 1 .00 39 .00 1SG1960
ATOM 1960 O LEU 259 77, .105 34, .786 37. .361 1, .00 39, .00 1SG1961
ATOM 1961 N ASP 260 78, .325 35, .502 39, .120 1, .00 35, .93 1SG1962
ATOM 1962 CA ASP 260 77, .166 35 .865 39 .874 1, .00 35. .93 1SG1963
ATOM 1963 CB ASP 260 77 .161 35 .276 41 .295 1, .00 35. .93 1SG1964
ATOM 1964 CG ASP 260 75. .768 35 .450 41, .878 1, .00 35. .93 1SG1965
ATOM 1965 OD1 ASP 260 74. .871 35, .932 41, .135 1, .00 35. .93 1SG1966
ATOM 1966 OD2 ASP 260 75. .581 35, .102 43 .074 1, .00 35. .93 1SG1967
ATOM 1967 C ASP 260 77 .197 37 .353 40 .002 1, .00 35 .93 1SG1968
ATOM 1968 0 ASP 260 78. .208 37. .926 40 .404 1. .00 35. .93 1SG1969
ATOM 1969 N ILE 261 76, .085 38 .024 39 .649 1. .00 34. .07 1SG1970
ATOM 1970 CA ILE 261 76, .059 39 .452 39 .739 1, .00 34, .07 1SG1971
ATOM 1971 CB ILE 261 75, .590 40 .130 38 .481 1, .00 34. .07 1SG1972
ATOM 1972 CG2 ILE 261 74 .134 39 .715 38 .212 1 .00 34. .07 1SG1973
ATOM 1973 CGI ILE 261 75, .809 41 .649 38 .579 1, .00 34. .07 1SG1974
ATOM 1974 CDl ILE 261 75, .653 42 .376 37, .244 1, .00 34. .07 1SG1975
ATOM 1975 C ILE 261 75, .120 39 .817 40 .839 1, .00 34. .07 1SG1976
ATOM 1976 O ILE 261 74 .006 39 .302 40 .922 1 .00 34. .07 1SG1977
ATOM 1977 N THR 262 75. .574 40, .716 41 .734 1, .00 34. .20 1SG1978 ATOM 1978 CA THR 262 74..764 41..126 42,.840 1..00 34..20 1SG1979
ATOM 1979 CB THR 262 75, .416 40. .924 44, .176 1. .00 34. .20 1SG1980
ATOM 1980 OGl THR 262 74 .487 41. .176 45 .219 1. .00 34. .20 1SG1981
ATOM 1981 CG2 THR 262 76 .616 41. .879 44 .290 1. .00 34, .20 1SG1982
ATOM 1982 C THR 262 74 .508 42, .589 42 .686 1. .00 34, .20 1SG1983
ATOM 1983 O THR 262 75 .181 43, .278 41, .921 1. .00 34, .20 1SG1984
ATOM 1984 N GLY 263 73 .501 43, .092 43 .421 1. .00 34, .50 1SG1985
ATOM 1985 CA GLY 263 73 .083 44, .462 43 .348 1, .00 34 , .50 1SG1986
ATOM 1986 C GLY 263 74, .194 45, .369 43, .774 1, .00 34 , .50 1SG1987
ATOM 1987 O GLY 263 74, .326 46. .481 43, .267 1. .00 34. .50 1SG1988
ATOM 1988 N GLN 264 75, .013 44. .924 44, .740 1. .00 37. .98 1SG1989
ATOM 1989 CA GLN 264 76 .046 45, .748 45 .302 1 .00 37. .98 1SG1990
ATOM 1990 CB GLN 264 76 .829 45, .032 46 .416 1. .00 37, .98 1SG1991
ATOM 1991 CG GLN 264 77 .921 45, .896 47 .048 1. .00 37, .98 1SG1992
ATOM 1992 CD GLN 264 77 .242 46, .964 47 .894 1. .00 37, .98 1SG1993
ATOM 1993 OEl GLN 264 76 .222 47, .529 47 .502 1, .00 37, .98 1SG1994
ATOM 1994 NE2 GLN 264 77, .817 47, .245 49, .094 1, .00 37, .98 1SG1995
ATOM 1995 C GLN 264 77 .033 46, .153 44 .248 1. .00 37, .98 1SG1996
ATOM 1996 O GLN 264 77, .553 47. .267 44, .277 1. .00 37, .98 1SG1997
ATOM 1997 N LEU 265 77, .320 45. .260 43. .286 1. .00 41, .71 1SG1998
ATOM 1998 CA LEU 265 78 .330 45. .505 42 .296 1 .00 41 .71 1SG1999
ATOM 1999 CB LEU 265 78 .514 44, .293 41 .357 1 .00 41 .71 1SG2000
ATOM 2000 CG LEU 265 79 .595 44, .442 40 .263 1 .00 41. .71 1SG2001
ATOM 2001 CD2 LEU 265 80 .948 44, .824 40 .883 1. .00 41, .71 1SG2002
ATOM 2002 CDl LEU 265 79 .170 45, .390 39 .128 1. .00 41, .71 1SG2003
ATOM 2003 C LEU 265 77 .987 46, .711 41 .471 1. .00 41, .71 1SG2004
ATOM 2004 O LEU 265 78, .875 47, .473 41. .091 1, .00 41, .71 1SG2005
ATOM 2005 N ARG 266 76, .697 46, .914 41. .150 1, .00 45, .93 1SG2006
ATOM 2006 CA ARG 266 76, .321 47, .975 40. .255 1. .00 45, .93 1SG2007
ATOM 2007 CB ARG 266 74 .969 47 .750 39 .556 1 .00 45 .93 1SG2008
ATOM 2008 CG ARG 266 74 .915 46, .508 38 .666 1. .00 45 ,93 1SG2009
ATOM 2009 CD ARG 266 73 .631 46, .431 37 .838 1. .00 45, ,93 1SG2010
ATOM 2010 NE ARG 266 73 .516 45, .047 37 .300 1, .00 45, .93 1SG2011
ATOM 2011 CZ ARG 266 72 .278 44, .524 37 .062 1. .00 45, .93 1SG2012
ATOM 2012 NHl ARG 266 71, .167 45. .290 37, .271 1. .00 45, .93 1SG2013
ATOM 2013 NH2 ARG 266 72. .145 43 , .236 36, .630 1, .00 45, .93 1SG2014
ATOM 2014 C ARG 266 76, .224 49. .308 40, .926 1. .00 45. , 93 1SG2015
ATOM 2015 O ARG 266 76, .147 49. .427 42, .148 1. .00 45. ,93 1SG2016
ATOM 2016 N SER 267 76 .248 50. .354 40 .070 1. .00 49. ,92 1SG2017
ATOM 2017 CA SER 267 76 .121 51, .741 40 .415 1, .00 49. .92 1SG2018
ATOM 2018 CB SER 267 76 .914 52, .680 39 .491 1, .00 49. .92 1SG2019
ATOM 2019 OG SER 267 78, .306 52, .439 39 .632 1. .00 49. .92 1SG2020
ATOM 2020 C SER 267 74, .670 52. .101 40, .287 1. .00 49. .92 1SG2021
ATOM 2021 O SER 267 73, .793 51. .252 40, .430 1. .00 49. .92 1SG2022
ATOM 2022 N ASP 268 74, .391 53. .398 40, .039 1. .00 52. .29 1SG2023
ATOM 2023 CA ASP 268 73. .051 53. .915 39, .999 1. .00 52. ,29 1SG2024
ATOM 2024 CB ASP 268 73. .004 55. .420 40, .337 1. .00 52. .29 1SG2025
ATOM 2025 CG ASP 268 71. .607 55. .815 40 .804 1. .00 52. .29 1SG2026
ATOM 2026 OD1 ASP 268 70. .786 54, .899 41. .075 1. .00 52. .29 1SG2027
ATOM 2027 OD2 ASP 268 71, .348 57. .044 40. .906 1. .00 52. .29 1SG2028
ATOM 2028 C ASP 268 72, .411 53. .725 38, .649 1. .00 52. .29 1SG2029
ATOM 2029 O ASP 268 73, .016 53. .209 37, .711 1. .00 52. ,29 1SG2030
ATOM 2030 N ASP 269 71. .123 54. .137 38, .592 1. .00 53. .52 1SG2031
ATOM 2031 CA ASP 269 70. .143 54. .200 37. .536 1. .00 53. .52 1SG2032
ATOM 2032 CB ASP 269 70. .586 54. ,994 36. .286 1. ,00 53. .52 1SG2033
ATOM 2033 CG ASP 269 71. .717 54. ,283 35. .557 1. ,00 53. 52 1SG2034
ATOM 2034 OD1 ASP 269 71, .499 53. .140 35, .072 1. .00 53. ,52 1SG2035 ATOM 2035 OD2 ASP 269 72.823 54,.881 35..475 1..00 53..52 1SG2036
ATOM 2036 C ASP 269 69 .711 52, .834 37 .126 1, .00 53, .52 1SG2037
ATOM 2037 O ASP 269 68 .709 52, .673 36. .431 1. .00 53, .52 1SG2038
ATOM 2038 N ASN 270 70 .412 51, .799 37. .607 1, .00 51, .26 1SG2039
ATOM 2039 CA ASN 270 69 .994 50, .468 37 .301 1, .00 51, .26 1SG2040
ATOM 2040 CB ASN 270 70 .888 49, .755 36, .272 1. .00 51, .26 1SG2041
ATOM 2041 CG ASN 270 70 .690 50. .434 34, .923 1. .00 51, .26 1SG2042
ATOM 2042 OD1 ASN 270 71 .651 50. .737 34, .218 1. .00 51, .26 1SG2043
ATOM 2043 ND2 ASN 270 69 .405 50. .680 34, .551 1. .00 51, .26 1SG2044
ATOM 2044 C ASN 270 70 .130 49. .743 38, .587 1. .00 51, .26 1SG2045
ATOM 2045 0 ASN 270 71 .154 49. .856 39 .260 1, .00 51, .26 1SG2046
ATOM 2046 N LEU 271 69 .090 48. .995 38, .985 1. .00 47, .45 1SG2047
ATOM 2047 CA LEU 271 69. .203 48. .325 40. .239 1. .00 47, .45 1SG2048
ATOM 2048 CB LEU 271 68 .285 48. .914 41. .325 1. .00 47, .45 1SG2049
ATOM 2049 CG LEU 271 68 .568 50. .394 41. .645 1, .00 47, .45 1SG2050
ATOM 2050 CD2 LEU 271 67 .805 50. .851 42. .900 1. .00 47, .45 1SG2051
ATOM 2051 CDl LEU 271 68. .291 51. .292 40. .428 1, .00 47, .45 1SG2052
ATOM 2052 C LEU 271 68. .778 46. .912 40, .039 1. .00 47, .45 1SG2053
ATOM 2053 O LEU 271 67, .858 46. .629 39, .273 1. .00 47, .45 1SG2054
ATOM 2054 N LEU 272 69. .459 45. .980 40, .727 1. .00 43 , .31 1SG2055
ATOM 2055 CA LEU 272 69. .051 44. .615 40, .651 1. .00 43 , .31 1SG2056
ATOM 2056 CB LEU 272 70. .199 43. .626 40, .912 1. .00 43, .31 1SG2057
ATOM 2057 CG LEU 272 71, .350 43. .700 39, .894 1. .00 43 .31 1SG2058
ATOM 2058 CD2 LEU 272 72 .290 42. .495 40 .038 1. .00 43 .31 1SG2059
ATOM 2059 CDl LEU 272 72 .090 45. .043 39 .984 1. .00 43 .31 1SG2060
ATOM 2060 C LEU 272 68 .107 44. .469 41 .792 1, .00 43 .31 1SG2061
ATOM 2061 O LEU 272 68 .418 43, .827 42 .795 1, .00 43 .31 1SG2062
ATOM 2062 N ASN 273 66 .918 45, .079 41 .658 1. .00 37 .81 1SG2063
ATOM 2063 CA ASN 273 65 .948 45, .016 42 .705 1. .00 37 .81 1SG2064
ATOM 2064 CB ASN 273 65 .816 46, .321 43. .511 1. .00 37, .81 1SG2065
ATOM 2065 CG ASN 273 67 .049 46. .505 44, .382 1. .00 37, .81 1SG2066
ATOM 2066 OD1 ASN 273 68 .165 46, .658 43 .889 1. .00 37, .81 1SG2067
ATOM 2067 ND2 ASN 273 66, .839 46, .499 45, .726 1, .00 37, .81 1SG2068
ATOM 2068 C ASN 273 64 .629 44, .802 42, .051 1. .00 37, .81 1SG2069
ATOM 2069 O ASN 273 64, .431 45, .147 40, .887 1. .00 37, .81 1SG2070
ATOM 2070 N THR 274 63, .688 44. .217 42, .806 1. .00 34, .64 1SG2071
ATOM 2071 CA THR 274 62 .372 43. .987 42, .299 1. .00 34, .64 1SG2072
ATOM 2072 CB THR 274 61, .492 43. .261 43, .277 1. .00 34, .64 1SG2073
ATOM 2073 OGl THR 274 61, .325 44. .036 44, .456 1. .00 34. .64 1SG2074
ATOM 2074 CG2 THR 274 62, .136 41. .905 43 , .615 1. .00 34. .64 1SG2075
ATOM 2075 C THR 274 61, .770 45. .331 42. .047 1. .00 34. .64 1SG2076
ATOM 2076 O THR 274 61, .008 45. .516 41. .100 1. .00 34. .64 1ΞG2077
ATOM 2077 N SER 275 62, .104 46. ,310 42. .908 1. .00 32. .68 1SG2078
ATOM 2078 CA SER 275 61, .538 47. ,624 42. .809 1. ,00 32. .68 1SG2079
ATOM 2079 CB SER 275 62. .099 48. ,588 43. .868 1. ,00 32. .68 1SG2080
ATOM 2080 OG SER 275 61 .504 49. .870 43, .732 1. .00 32 , .68 1SG2081
ATOM 2081 C SER 275 61. .845 48. .211 41, .465 1. .00 32. .68 1SG2082
ATOM 2082 O SER 275 60. .940 48. .649 40. .757 1. .00 32. .68 1SG2083
ATOM 2083 N ALA 276 63. .133 48. .228 41. .071 1. .00 31. .89 1SG2084
ATOM 2084 CA ALA 276 63. .509 48. .821 39. .817 1. .00 31. .89 1SG2085
ATOM 2085 CB ALA 276 65, .025 48. .771 39. .562 1. .00 31. .89 1SG2086
ATOM 2086 C ALA 276 62, .852 48. .059 38. .715 1. .00 31. .89 1SG2087
ATOM 2087 O ALA 276 62 , .310 48. .636 37. .774 1. .00 31. .89 1SG2088
ATOM 2088 N LEU 277 62, .855 46. .724 38. .841 1. .00 34. .59 1SG2089
ATOM 2089 CA LEU 277 62. .279 45. .852 37. .863 1. .00 34. ,59 1SG2090
ATOM 2090 CB LEU 277 62. .408 44. ,358 38. .215 1. .00 34. .59 1SG2091
ATOM 2091 CG LEU 277 63. .856 43. .836 38. .194 1. ,00 34. ,59 1SG2092 ATOM 2092 CD2 LEU 277 64..559 44 ,.204 36,.878 1..00 34..59 1SG2093
ATOM 2093 CDl LEU 277 63. .911 42. .329 38. .498 1. .00 34. .59 1SG2094
ATOM 2094 C LEU 277 60, .823 46. .162 37. .792 1. .00 34. .59 1SG2095
ATOM 2095 O LEU 277 60. .166 45. .890 36 .789 1, .00 34. .59 1SG2096
ATOM 2096 N GLY 278 60. .280 46. .730 38. .879 1. .00 40. ,86 1SG2097
ATOM 2097 CA GLY 278 58, .872 46. .980 38, .980 1, .00 40. .86 1SG2098
ATOM 2098 C GLY 278 58 .407 47 .833 37 .843 1. .00 40. .86 1SG2099
ATOM 2099 O GLY 278 57. .283 47, .675 37, .370 1. .00 40. .86 1SG2100
ATOM 2100 N ARG 279 59. .225 48, .792 37, .383 1. .00 51. .89 1SG2101
ATOM 2101 CA ARG 279 58. .727 49, .615 36, .322 1, .00 51. .89 1SG2102
ATOM 2102 CB ARG 279 59. .743 50, .676 35, .872 1. .00 51. .89 1SG2103
ATOM 2103 CG ARG 279 60 .040 51, .717 36 .952 1. .00 51, .89 1SG2104
ATOM 2104 CD ARG 279 61. .105 52, .739 36, .550 1. .00 51, .89 1SG2105
ATOM 2105 NE ARG 279 60, .435 53, .815 35, .769 1. .00 51. .89 1SG2106
ATOM 2106 CZ ARG 279 61, .103 54, .977 35, .505 1, .00 51. .89 1SG2107
ATOM 2107 NHl ARG 279 62, .386 55, .140 35, .939 1. .00 51. .89 1SG2108
ATOM 2108 NH2 ARG 279 60. .485 55, .975 34. .808 1. .00 51. .89 1SG2109
ATOM 2109 C ARG 279 58. .418 48, .759 35, .126 1. .00 51, .89 1SG2110
ATOM 2110 O ARG 279 57. .342 48, .874 34, .538 1, .00 51, .89 1SG2111
ATOM 2111 N LEU 280 59. .380 47, .911 34, .709 1, .00 64, .64 1SG2112
ATOM 2112 CA LEU 280 59. .213 47, .068 33 .557 1 .00 64 .64 1SG2113
ATOM 2113 CB LEU 280 60. .550 46. .553 33. .000 1. .00 64, .64 1SG2114
ATOM 2114 CG LEU 280 61, .443 47, .672 32. .433 1. .00 64, .64 1SG2115
ATOM 2115 CD2 LEU 280 62 .627 47 .099 31 .637 1, .00 64 .64 1SG2116
ATOM 2116 CDl LEU 280 61. .880 48, .649 33. .535 1, .00 64 .64 1SG2117
ATOM 2117 C LEU 280 58, .340 45, .864 33. .772 1, .00 64, .64 1SG2118
ATOM 2118 O LEU 280 57, .431 45, .629 32 .976 1 .00 64 .64 1SG2119
ATOM 2119 N ILE 281 58, .605 45, .049 34. .824 1, .00 75, .30 1SG2120
ATOM 2120 CA ILE 281 57 .819 4 .853 34 .984 1 .00 75 .30 1SG2121
ATOM 2121 CB ILE 281 58, .549 42, .573 34, .675 1, .00 75. .30 1SG2122
ATOM 2122 CG2 ILE 281 58, .832 42, .565 33, .167 1, .00 75, .30 1SG2123
ATOM 2123 CGI ILE 281 59, .794 42, .381 35. .558 1, .00 75, .30 1SG2124
ATOM 2124 CDl ILE 281 60. .871 43 , .440 35, .336 1, .00 75, .30 1SG2125
ATOM 2125 C ILE 281 57. .247 43. .748 36, .357 1, .00 75, .30 1SG2126
ATOM 2126 O ILE 281 57. .828 43. .192 37, .284 1, .00 75, .30 1SG2127
ATOM 2127 N PRO 282 56. .024 44. ,165 36. .404 1, .00 78, .32 1SG2128
ATOM 2128 CA PRO 282 55, .222 44, ,298 37, .585 1, .00 78, .32 1SG2129
ATOM 2129 CD PRO 282 55. .310 44 , .541 35, .195 1, .00 78, .32 1SG2130
ATOM 2130 CB PRO 282 53. .963 45. .029 37. .139 1. .00 78. .32 1SG2131
ATOM 2131 CG PRO 282 53. .850 44. .698 35, .641 1. .00 78, .32 1SG2132
ATOM 2132 C PRO 282 54. .886 43. .023 38 .251 1. .00 78, .32 1SG2133
ATOM 2133 O PRO 282 54. ,228 43. .087 39, .285 1. .00 78, .32 1SG2134
ATOM 2134 N GLU 283 55. .192 41. .868 37, .647 1. .00 72. .31 1SG2135
ATOM 2135 CA GLU 283 55, .019 40, .690 38, .415 1. .00 72, .31 1SG2136
ATOM 2136 CB GLU 283 55. .118 39. .409 37, .583 1. .00 72. .31 1SG2137
ATOM 2137 CG GLU 283 54, .720 38. .179 38, .393 1, .00 72. .31 1SG2138
ATOM 2138 CD GLU 283 53. .262 38. .349 38, .804 1. .00 72. .31 1SG2139
ATOM 2139 OEl GLU 283 52. .422 38. .630 37. .912 1. .00 72. .31 1SG2140
ATOM 2140 OE2 GLU 283 52. .973 38. .201 40. .024 1. .00 72. .31 1SG2141
ATOM 2141 C GLU 283 56. .100 40. .680 39. .462 1. .00 72. .31 1SG2142
ATOM 2142 O GLU 283 55. .841 40. ,376 40. .619 1. ,00 72. .31 1SG2143
ATOM 2143 N VAL 284 57. .348 41. .063 39. .104 1. .00 60. .97 1SG2144
ATOM 2144 CA VAL 284 58. ,428 40. ,971 40. .052 1. ,00 60. ,97 1SG2145
ATOM 2145 CB VAL 284 59. .763 41. .423 39. .513 1. .00 60. .97 1SG2146
ATOM 2146 CGI VAL 284 60. .116 40. .548 38. .301 1. .00 60. .97 1SG2147
ATOM 2147 CG2 VAL 284 59. .746 42. .931 39. .212 1. .00 60. .97 1SG2148
ATOM 2148 C VAL 284 58. .143 41. .766 41. ,289 1. ,00 60. ,97 1SG2149 ATOM 2149 O VAL 284 58,.344 41..285 42..404 1..00 60..97 1SG2150
ATOM 2150 N ALA 285 57, .693 43. .019 41. ,136 1. .00 50. .29 1SG2151
ATOM 2151 CA ALA 285 57, .413 43. .825 42. .284 1. .00 50. .29 1SG2152
ATOM 2152 CB ALA 285 57, .069 45. .276 41, .900 1. .00 50, .29 1SG2153
ATOM 2153 C ALA 285 56, .247 43. .238 43. .014 1. .00 50. .29 1SG2154
ATOM 2154 O ALA 285 56 .240 43. .156 44, .240 1, .00 50, .29 1SG2155
ATOM 2155 N ARG 286 55, .227 42. .814 42. .253 1. .00 44 , .38 1SG2156
ATOM 2156 CA ARG 286 53 .978 42. .336 42, .769 1, .00 44, .38 1SG2157
ATOM 2157 CB ARG 286 53, .063 41. .982 41. .587 1. .00 44, .38 1SG2158
ATOM 2158 CG ARG 286 51. .565 41, .918 41. .856 1, .00 44. .38 1SG2159
ATOM 2159 CD ARG 286 50 .819 41, .530 40. .578 1. .00 44. .38 1SG2160
ATOM 2160 NE ARG 286 49. .396 41, .946 40. .703 1, .00 44, .38 1SG2161
ATOM 2161 CZ ARG 286 48. .459 41. .099 41. .224 1. .00 44, .38 1SG2162
ATOM 2162 NHl ARG 286 48. .824 39. .889 41. .730 1. .00 44, .38 1SG2163
ATOM 2163 NH2 ARG 286 47 .148 41. .481 41, .232 1, .00 44 .38 1SG2164
ATOM 2164 C ARG 286 54 .172 41. .094 43, .593 1, .00 44 .38 1SG2165
ATOM 2165 O ARG 286 53. .761 41. .028 44, .752 1, .00 44 .38 1SG2166
ATOM 2166 N GLN 287 54. .812 40. .077 42. .989 1. .00 45, .92 1SG2167
ATOM 2167 CA GLN 287 55. .041 38, .788 43, .562 1, .00 45 .92 1SG2168
ATOM 2168 CB GLN 287 55 .566 37, .821 42, .486 1 .00 45 .92 1SG2169
ATOM 2169 CG GLN 287 55. .595 36 .343 42 .871 1 .00 45 .92 1SG2170
ATOM 2170 CD GLN 287 55, .825 35. .561 41. .581 1. .00 45, .92 1SG2171
ATOM 2171 OEl GLN 287 56, .876 34. .956 41. .378 1, .00 45 .92 1SG2172
ATOM 2172 NE2 GLN 287 54 .810 35. .580 40. .675 1, .00 45 .92 1SG2173
ATOM 2173 C GLN 287 56 .031 38 .897 44. .676 1, .00 45 .92 1SG2174
ATOM 2174 O GLN 287 55, .802 38. .391 45, .772 1, .00 45 .92 1SG2175
ATOM 2175 N PHE 288 57, .169 39. .575 44. .432 1. .00 51, .47 1SG2176
ATOM 2176 CA PHE 288 58 .095 39. .722 45. .510 1. .00 51 .47 1SG2177
ATOM 2177 CB PHE 288 59 .453 39 .048 45. .270 1 .00 51 .47 1SG2178
ATOM 2178 CG PHE 288 59, .146 37. .592 45. .248 1. .00 51 .47 1SG2179
ATOM 2179 CDl PHE 288 58 .890 36. .906 46. .414 1, .00 51 .47 1SG2180
ATOM 2180 CD2 PHE 288 59, .113 36, .917 44. .051 1, .00 51, .47 1SG2181
ATOM 2181 CE1 PHE 288 58 .603 35, .563 46. .380 1, .00 51 .47 1SG2182
ATOM 2182 CE2 PHE 288 58, .827 35. .575 44. .011 1, .00 51 .47 1SG2183
ATOM 2183 CZ PHE 288 58 .574 34, .895 45, .178 1, .00 51 .47 1SG2184
ATOM 2184 C PHE 288 58 .289 41, .183 45, .716 1, .00 51 .47 1SG2185
ATOM 2185 O PHE 288 59 .108 41, .844 45, .081 1. .00 51, .47 1SG2186
ATOM 2186 N PRO 289 57, .499 41. .658 46. .632 1, .00 57 .50 1SG2187
ATOM 2187 CA PRO 289 57, .468 43. .051 46. .976 1, .00 57, .50 1SG2188
ATOM 2188 CD PRO 289 56 .212 41, .026 46. .853 1, .00 57 .50 1SG2189
ATOM 2189 CB PRO 289 56 .070 43, .332 47. .527 1, .00 57 .50 1SG2190
ATOM 2190 CG PRO 289 55. .497 41. .945 47. .853 1, .00 57, .50 1SG2191
ATOM 2191 C PRO 289 58, .528 43. .384 47. .957 1. .00 57. .50 1SG2192
ATOM 2192 O PRO 289 59, .256 42, .484 48. .376 1. .00 57. .50 1SG2193
ATOM 2193 N GLU 290 58 .571 44, .662 48. .381 1. .00 63. .93 1SG2194
ATOM 2194 CA GLU 290 59 .572 45, .080 49, .313 1, .00 63 .93 1SG2195
ATOM 2195 CB GLU 290 59. .457 44. ,381 50. .682 1. .00 63. .93 1SG2196
ATOM 2196 CG GLU 290 58. .123 44. .595 51. .408 1. .00 63. .93 1SG2197
ATOM 2197 CD GLU 290 58. .231 45, .801 52. .333 1. .00 63. .93 1SG2198
ATOM 2198 OEl GLU 290 58 .702 46, .868 51. .864 1. .00 63. .93 1SG2199
ATOM 2199 OE2 GLU 290 57. .843 45. .668 53. .525 1. .00 63, .93 1SG2200
ATOM 2200 C GLU 290 60. .849 44. ,679 48. .713 1. .00 63. .93 1SG2201
ATOM 2201 0 GLU 290 61. .450 43. .658 49. ,060 1. ,00 63. .93 1SG2202
ATOM 2202 N PRO 291 61, .181 45. .569 47. .809 1. .00 64, .49 1SG2203
ATOM 2203 CA PRO 291 62, .250 45. .416 46. .862 1. .00 64, .49 1SG2204
ATOM 2204 CD PRO 291 60, .952 46. .969 48. .120 1. .00 64. .49 1SG2205
ATOM 2205 CB PRO 291 62. .710 46. ,824 46. ,475 1. .00 64. .49 1SG2206 ATOM 2206 CG PRO 291 61..584 47,.749 46..960 1..00 64..49 1SG2207
ATOM 2207 C PRO 291 63. .372 44, .671 47. .457 1, .00 64. .49 1SG2208
ATOM 2208 O PRO 291 64. .133 45, .226 48, .248 1. .00 64, .49 1SG2209
ATOM 2209 N MET 292 63. .482 43, .398 47, .065 1. .00 62, .89 1SG2210
ATOM 2210 CA MET 292 64, .564 42, .621 47, .546 1. .00 62, .89 1SG2211
ATOM 2211 CB MET 292 64, .233 41, .176 47, .960 1, .00 62. .89 1SG2212
ATOM 2212 CG MET 292 63, .397 40, .388 46, .956 1. .00 62. .89 1SG2213
ATOM 2213 SD MET 292 61, .611 40, ,674 47, .117 1. .00 62, .89 1SG2214
ATOM 2214 CE MET 292 61 .488 39 ,853 48, .734 1. .00 62 .89 1SG2215
ATOM 2215 C MET 292 65, .514 42, .597 46, .421 1. .00 62, .89 1SG2216
ATOM 2216 O MET 292 65, .203 43, .031 45, .312 1. .00 62, .89 1SG2217
ATOM 2217 N PRO 293 66 .685 42 .145 46 .706 1. .00 57 .82 1SG2218
ATOM 2218 CA PRO 293 67, .666 42, .166 45, .676 1, .00 57, .82 1SG2219
ATOM 2219 CD PRO 293 67. .267 42, .331 48, .025 1. .00 57, .82 1SG2220
ATOM 2220 CB PRO 293 69. .010 41, .975 46, .375 1. .00 57. .82 1SG2221
ATOM 2221 CG PRO 293 68. .767 42, .556 47 .780 1, .00 57 .82 1SG2222
ATOM 2222 C PRO 293 67, .353 41, .135 44, .658 1, .00 57. .82 1SG2223
ATOM 2223 O PRO 293 66, .677 40, .157 44, .974 1, .00 57, .82 1SG2224
ATOM 2224 N VAL 294 67, .805 41 .355 43 .417 1 .00 49 .37 1SG2225
ATOM 2225 CA VAL 294 67, .618 40, .351 42 .426 1, .00 49 .37 1SG2226
ATOM 2226 CB VAL 294 66, .972 40, .830 41, .155 1 .00 49 .37 1SG2227
ATOM 2227 CGI VAL 294 65, .576 41, .382 41, .490 1, .00 49, .37 1SG2228
ATOM 2228 CG2 VAL 294 67, .899 41, .842 40 .467 1 .00 49 .37 1SG2229
ATOM 2229 C VAL 294 69, .002 39, .907 42, .099 1, .00 49 .37 1SG2230
ATOM 2230 O VAL 294 69, .910 40, .730 41, .990 1, .00 49 .37 1SG2231
ATOM 2231 N VAL 295 69, .209 38 .584 41 .977 1 .00 44 .23 1SG2232
ATOM 2232 CA VAL 295 70, .521 38, .100 41, .675 1, .00 44 .23 1SG2233
ATOM 2233 CB VAL 295 71, .000 37, .018 42, .595 1, .00 44 .23 1SG2234
ATOM 2234 CGI VAL 295 70. .064 35, .803 42, .459 1 .00 44 .23 1SG2235
ATOM 2235 CG2 VAL 295 72, .464 36, .703 4 .244 1 .00 44 .23 1SG2236
ATOM 2236 C VAL 295 70, .466 37, .505 40, .308 1, .00 44 .23 1SG2237
ATOM 2237 O VAL 295 69, .513 36, .808 39, .965 1. .00 44 .23 1SG2238
ATOM 2238 N LEU 296 71, .493 37 .783 39 .482 1 .00 40 .01 1SG2239
ATOM 2239 CA LEU 296 71, .506 37, .231 38 .159 1 .00 40 .01 1SG2240
ATOM 2240 CB LEU 296 71. .705 38, .261 37, .032 1. .00 40 .01 1SG2241
ATOM 2241 CG LEU 296 70. .550 39 .257 36 .827 1, .00 40 .01 1SG2242
ATOM 2242 CD2 LEU 296 70, .716 40 .016 35, .500 1 .00 40 .01 1SG2243
ATOM 2243 CDl LEU 296 70, .386 40, .195 38, .034 1, .00 40 .01 1SG2244
ATOM 2244 C LEU 296 72. .671 36, ,303 38, .055 1, .00 40, .01 1SG2245
ATOM 2245 O LEU 296 73, .780 36, .630 38 .475 1 .00 40 .01 1SG2246
ATOM 2246 N LYS 297 72, .448 35, .107 37, .480 1, .00 38, .55 1SG2247
ATOM 2247 CA LYS 297 73. .547 34, .203 37, .338 1, .00 38. .55 1SG2248
ATOM 2248 CB LYS 297 73, .292 32, .811 37, .939 1, .00 38 .55 1SG2249
ATOM 2249 CG LYS 297 73, .278 32, .819 39, .469 1, .00 38, .55 1SG2250
ATOM 2250 CD LYS 297 72. .683 31, .554 40, .086 1, .00 38, .55 1SG2251
ATOM 2251 CE LYS 297 73. .441 30. .279 39. .715 1. .00 38, .55 1SG2252
ATOM 2252 NZ LYS 297 72. .816 29, .111 40, .373 1. .00 38, .55 1SG2253
ATOM 2253 C LYS 297 73, .827 34, .044 35, .884 1. .00 38, .55 1SG2254
ATOM 2254 O LYS 297 72. .923 33. .810 35. .083 1. .00 38. .55 1SG2255
ATOM 2255 N VAL 298 75. .112 34. .189 35. .509 1. .00 38. .41 1SG2256
ATOM 2256 CA VAL 298 75. .456 34. .045 34, .131 1. .00 38. .41 1SG2257
ATOM 2257 CB VAL 298 76. .155 35. .241 33. .549 1. .00 38. .41 1SG2258
ATOM 2258 CGI VAL 298 77. .573 35. .347 34. .128 1. .00 38. .41 1SG2259
ATOM 2259 CG2 VAL 298 76. .108 35, .129 32. .021 1. .00 38, .41 1SG2260
ATOM 2260 C VAL 298 76. .347 32. .850 34. .007 1. .00 38. .41 1SG2261
ATOM 2261 O VAL 298 77. .320 32. .692 34. .744 1. .00 38. .41 1SG2262
ATOM 2262 N ARG 299 76. .008 31. .953 33. .062 1. .00 35. .51 1SG2263 ATOM 2263 CA ARG 299 76,.792 30,.775 32,.845 1.,00 35..51 1SG2264
ATOM 2264 CB ARG 299 76, .129 29, .480 33, .351 1. .00 35. .51 1SG2265
ATOM 2265 CG ARG 299 75 .862 29, .465 34 .857 1. .00 35. .51 1SG2266
ATOM 2266 CD ARG 299 75, .297 28. .142 35 .384 1, .00 35. .51 1SG2267
ATOM 2267 NE ARG 299 76, .432 27. .362 35, .956 1. .00 35. .51 1SG2268
ATOM 2268 CZ ARG 299 76, .917 26, .262 35, .311 1. .00 35. .51 1SG2269
ATOM 2269 NHl ARG 299 76 .326 25, .826 34 .160 1. .00 35. .51 1SG2270
ATOM 2270 NH2 ARG 299 77, .987 25 .589 35 .826 1. .00 35, .51 1SG2271
ATOM 2271 C ARG 299 76, .908 30. .625 31, .367 1. .00 35. .51 1SG2272
ATOM 2272 O ARG 299 76 .129 31. .208 30, .615 1. .00 35. .51 1SG2273
ATOM 2273 N LEU 300 77 .901 29. .841 30 .909 1. .00 33. .13 1SG2274
ATOM 2274 CA LEU 300 78 .046 29 .631 29 .499 1, .00 33. .13 1SG2275
ATOM 2275 CB LEU 300 79, .506 29, .470 29, .026 1. .00 33. .13 1SG2276
ATOM 2276 CG LEU 300 80 .249 28, .250 29, .603 1. .00 33. .13 1SG2277
ATOM 2277 CD2 LEU 300 80 .202 28 .227 31 .139 1. .00 33. .13 1SG2278
ATOM 2278 CDl LEU 300 81 .691 28 .177 29 .076 1, .00 33. .13 1SG2279
ATOM 2279 C LEU 300 77 .299 28, .380 29, .169 1, .00 33 .13 1SG2280
ATOM 2280 O LEU 300 77 .534 27 .325 29 .757 1. .00 33, .13 1SG2281
ATOM 2281 N GLY 301 76 .328 28 .496 28 .241 1. .00 30, .51 1SG2282
ATOM 2282 CA GLY 301 75 .516 27 .386 27 .841 1 .00 30 .51 1SG2283
ATOM 2283 C GLY 301 76 .340 26 .377 27 .104 1 .00 30 .51 1SG2284
ATOM 2284 O GLY 301 76 .230 25 .177 27 .351 1. .00 30, .51 1SG2285
ATOM 2285 N ALA 302 77 .193 26 .844 26 .172 1, .00 29 .73 1SG2286
ATOM 2286 CA ALA 302 77 .964 25, .935 25, .374 1, .00 29, .73 1SG2287
ATOM 2287 CB ALA 302 77, .418 25. .754 23 .947 1, .00 29, .73 1SG2288
ATOM 2288 C ALA 302 79, .341 26, .497 25, .255 1. .00 29. .73 1SG2289
ATOM 2289 O ALA 302 79, .591 27, .641 25, .630 1. .00 29. .73 1SG2290
ATOM 2290 N THR 303 80 .287 25, .682 24, .749 1. .00 31. .42 1SG2291
ATOM 2291 CA THR 303 81. .640 26 .136 24 .636 1, .00 31, .42 1SG2292
ATOM 2292 CB THR 303 82 .601 25, .050 24, .249 1. .00 31, .42 1SG2293
ATOM 2293 OGl THR 303 82 .569 24, .001 25, .206 1. .00 31, .42 1SG2294
ATOM 2294 CG2 THR 303 84 .015 25 .650 24 .169 1, .00 31. .42 1SG2295
ATOM 2295 C THR 303 81 .694 27 .193 23 .582 1, .00 31 .42 1SG2296
ATOM 2296 O THR 303 81 .203 27, .028 22, .467 1. .00 31, .42 1SG2297
ATOM 2297 N PRO 304 82 .296 28, .291 23, .941 1. .00 32, .33 1SG2298
ATOM 2298 CA PRO 304 82 .444 29 .430 23, .080 1, .00 32, .33 1SG2299
ATOM 2299 CD PRO 304 83 .011 28 .427 25 .198 1, .00 32, .33 1SG2300
ATOM 2300 CB PRO 304 83. .132 30, .495 23, .936 1. .00 32, .33 1SG2301
ATOM 2301 CG PRO 304 83 .881 29, .680 25, .010 1. .00 32, .33 1SG2302
ATOM 2302 C PRO 304 83 .244 29 .038 21, .880 1, .00 32, .33 1SG2303
ATOM 2303 O PRO 304 84 .153 28 .218 21, .998 1. .00 32. .33 1SG2304
ATOM 2304 N VAL 305 82. .924 29, .605 20. .705 1, .00 32. .71 1SG2305
ATOM 2305 CA VAL 305 83, .658 29, .234 19. .535 1. .00 32. .71 1SG2306
ATOM 2306 CB VAL 305 82 .794 28 .745 18, .411 1, .00 32. .71 1SG2307
ATOM 2307 CGI VAL 305 81 .883 29 .898 17, .956 1, .00 32. .71 1SG2308
ATOM 2308 CG2 VAL 305 83. .706 28. .198 17. .301 1. .00 32. .71 1SG2309
ATOM 2309 C VAL 305 84. .383 30. .439 19. .042 1. .00 32. .71 1SG2310
ATOM 2310 O VAL 305 83, .912 31. .564 19. .190 1, ,00 32. ,71 1SG2311
ATOM 2311 N ALA 306 85, .580 30. .222 18. .464 1, .00 31. ,36 1SG2312
ATOM 2312 CA ALA 306 86. .337 31, .306 17. .916 1. .00 31. .36 1SG2313
ATOM 2313 CB ALA 306 87, .683 31. .529 18. .624 1. .00 31. .36 1SG2314
ATOM 2314 C ALA 306 86, .636 30, .929 16. .503 1. .00 31. .36 1SG2315
ATOM 2315 O ALA 306 87, .061 29, .809 16. .223 1. .00 31. .36 1SG2316
ATOM 2316 N MET 307 86, .419 31. .863 15. .560 1. .00 30. .28 1SG2317
ATOM 2317 CA MET 307 86. .686 31. .524 14. ,195 1. .00 30. .28 1SG2318
ATOM 2318 CB MET 307 85. .454 31. .662 13. .280 1. ,00 30. ,28 1SG2319
ATOM 2319 CG MET 307 84. .946 33. .098 13. .160 1. ,00 30. ,28 1SG2320 ATOM 2320 SD MET 307 83.,432 33..307 12..174 1.00 30.28 1SG2321
ATOM 2321 CE MET 307 84. .261 33. .180 10. .565 1. .00 30. ,28 1SG2322
ATOM 2322 C MET 307 87. .743 32. .451 13. ,704 1. .00 30. ,28 1SG2323
ATOM 2323 O MET 307 87. .676 33. .658 13. .934 1. ,00 30. ,28 1SG2324
ATOM 2324 N LEU 308 88. .777 31. .911 13. .027 1. ,00 29. ,81 1SG2325
ATOM 2325 CA LEU 308 89. ,756 32, .839 12. .555 1. ,00 29. ,81 1SG2326
ATOM 2326 CB LEU 308 91. .207 32, .604 12. .985 1. .00 29. .81 1SG2327
ATOM 2327 CG LEU 308 92. .078 33, .761 12. .459 1. .00 29. .81 1SG2328
ATOM 2328 CD2 LEU 308 93. .567 33. .519 12. .700 1. .00 29. .81 1SG2329
ATOM 2329 CDl LEU 308 91. .611 35. .107 13, .035 1. .00 29. ,81 1SG2330
ATOM 2330 C LEU 308 89. .737 32, .871 11. .068 1. ,00 29. ,81 1SG2331
ATOM 2331 O LEU 308 89. .687 31 .838 10. .401 1. .00 29. .81 1SG2332
ATOM 2332 N HIS 309 89. ,763 34. .100 10. .521 1. .00 29. .80 1SG2333
ATOM 2333 CA HIS 309 89. .784 34, .305 9. .108 1. ,00 29. .80 1SG2334
ATOM 2334 NDl HIS 309 86. .890 32 .738 9. .463 1. .00 29. .80 1SG2335
ATOM 2335 CG HIS 309 87. .597 33, .275 8. .410 1. .00 29. .80 1SG2336
ATOM 2336 CB HIS 309 88. .399 34, .540 8. .484 1. .00 29, .80 1SG2337
ATOM 2337 NE2 HIS 309 86. ,611 31, .359 7. .740 1. ,00 29. .80 1SG2338
ATOM 2338 CD2 HIS 309 87. .415 32, .421 7. .366 1. .00 29. .80 1SG2339
ATOM 2339 CE1 HIS 309 86. .321 31 .593 9. .007 1. .00 29. .80 1SG2340
ATOM 2340 C HIS 309 90. .637 35 .503 8. .848 1. .00 29, .80 1SG2341
ATOM 2341 O HIS 309 91. .092 36, .176 9. .772 1. .00 29. .80 1SG2342
ATOM 2342 N THR 310 90. .867 35, .797 7. .558 1. .00 30. .46 1SG2343
ATOM 2343 CA THR 310 91. .724 36 .868 7. .146 1. .00 30. .46 1SG2344
ATOM 2344 CB THR 310 91 .825 36 .985 5 .654 1, .00 30 .46 1SG2345
ATOM 2345 OGl THR 310 92. .325 35, .777 5. .100 1. .00 30. .46 1SG2346
ATOM 2346 CG2 THR 310 92. .768 38 .153 5. .319 1. .00 30, .46 1SG2347
ATOM 2347 C THR 310 91, .172 38, .158 7, .659 1. .00 30. .46 1SG2348
ATOM 2348 O THR 310 91. .924 39 .081 7. .970 1. .00 30 .46 1SG2349
ATOM 2349 N ASN 311 89, .835 38 .282 7. .724 1. .00 30, .13 1SG2350
ATOM 2350 CA ASN 311 89. .282 39, .524 8. .173 1. .00 30. .13 1SG2351
ATOM 2351 CB ASN 311 87. .743 39 .530 8. .142 1. .00 30. .13 1SG2352
ATOM 2352 CG ASN 311 87. .276 40, .962 8, .355 1. .00 30. .13 1SG2353
ATOM 2353 OD1 ASN 311 88, .048 41, .820 8, .780 1. .00 30. .13 1SG2354
ATOM 2354 ND2 ASN 311 85. .976 41 .231 8, .057 1, .00 30. .13 1SG2355
ATOM 2355 C ASN 311 89, .716 39 .789 9, .585 1, .00 30. .13 1SG2356
ATOM 2356 O ASN 311 90 .297 40 .837 .856 1, .00 30. .13 1SG2357
ATOM 2357 N ASN 312 89, .461 38 .835 10. .510 1, .00 30 .15 1SG2358
ATOM 2358 CA ASN 312 89. .812 38, .958 11. .906 1. .00 30, .15 1SG2359
ATOM 2359 CB ASN 312 89 .165 40 .140 12. .664 1, .00 30, .15 1SG2360
ATOM 2360 CG ASN 312 90, .002 41 .402 12. .507 1, .00 30, .15 1SG2361
ATOM 2361 OD1 ASN 312 89, .482 42 .479 12, .217 1, .00 30, .15 1SG2362
ATOM 2362 ND2 ASN 312 91, .340 41, .268 12, .709 1, .00 30, .15 1SG2363
ATOM 2363 C ASN 312 89, .311 37 .736 12. .606 1. .00 30. .15 1SG2364
ATOM 2364 O ASN 312 88 .840 36 .791 11, .976 1, .00 30, .15 1SG2365
ATOM 2365 N ALA 313 89, .408 37 .730 13, .953 1. .00 32. .14 1SG2366
ATOM 2366 CA ALA 313 88, .924 36, .611 14. .708 1. .00 32. .14 1SG2367
ATOM 2367 CB ALA 313 89 .897 36 .135 15. .801 1, .00 32, .14 1SG2368
ATOM 2368 C ALA 313 87, .665 37 .036 15. .391 1. .00 32, .14 1SG2369
ATOM 2369 O ALA 313 87 .589 38 .122 15. .965 1. .00 32, .14 1SG2370
ATOM 2370 N THR 314 86, .629 36, .177 15. .339 1. ,00 36. ,34 1SG2371
ATOM 2371 CA THR 314 85, .400 36 .525 15. .985 1. .00 36. .34 1SG2372
ATOM 2372 CB THR 314 84, .218 36, .603 15. .060 1. .00 36. .34 1SG2373
ATOM 2373 OGl THR 314 83, .957 35 .334 14. .483 1. .00 36, .34 1SG2374
ATOM 2374 CG2 THR 314 84, .520 37, .631 13. .957 1. .00 36, .34 1SG2375
ATOM 2375 C THR 314 85, .114 35, .475 17. .011 1. .00 36. ,34 1SG2376
ATOM 2376 O THR 314 85, .476 34, .310 16. .841 1. .00 36. .34 1SG2377 ATOM 2377 N LEU 315 84..473 35..881 18..127 1..00 41..98 1SG2378
ATOM 2378 CA LEU 315 84, .154 34. .961 19. .180 1, .00 41, .98 1SG2379
ATOM 2379 CB LEU 315 84 .714 35 .400 20 .553 1 .00 41 .98 1SG2380
ATOM 2380 CG LEU 315 84, .410 34. .455 21 .737 1 .00 41 .98 1SG2381
ATOM 2381 CD2 LEU 315 84 .897 33, .027 21. .436 1, .00 41, .98 1SG2382
ATOM 2382 CDl LEU 315 82 .937 34, .499 22, .173 1 .00 41, .98 1SG2383
ATOM 2383 C LEU 315 82 .663 34, .884 19, .271 1 .00 41 .98 1SG2384
ATOM 2384 O LEU 315 81 .972 35, .890 19, .113 1 .00 41 .98 1SG2385
ATOM 2385 N ARG 316 82, .125 33. .669 19. .509 1, .00 48, .56 1SG2386
ATOM 2386 CA ARG 316 80, .700 33. .519 19. .606 1, .00 48, .56 1SG2387
ATOM 2387 CB ARG 316 80 .142 32. .477 18, .621 1, .00 48, .56 1SG2388
ATOM 2388 CG ARG 316 78 .618 32 .497 18 .485 1 .00 48 .56 1SG2389
ATOM 2389 CD ARG 316 78 .112 33, .572 17, .523 1, .00 48 .56 1SG2390
ATOM 2390 NE ARG 316 78 .174 32, .994 16, .150 1 .00 48 .56 1SG2391
ATOM 2391 CZ ARG 316 77 .108 32, .298 15, .659 1 .00 48 .56 1SG2392
ATOM 2392 NHl ARG 316 75 .966 32, .192 16, .399 1 .00 48 .56 1SG2393
ATOM 2393 NH2 ARG 316 77, .181 31. .710 14. .428 1 .00 48 .56 1SG2394
ATOM 2394 C ARG 316 80, .393 33. .004 20. .978 1, .00 48, .56 1SG2395
ATOM 2395 O ARG 316 80 .589 31. .827 21, .269 1, .00 48 .56 1SG2396
ATOM 2396 N LEU 317 79 .874 33. .867 21, .867 1 .00 53 .59 1SG2397
ATOM 2397 CA LEU 317 79 .569 33. .390 23 .183 1 .00 53 .59 1SG2398
ATOM 2398 CB LEU 317 80 .140 34, .282 24, .306 1 .00 53 .59 1SG2399
ATOM 2399 CG LEU 317 79 .719 35, .765 24, .255 1 .00 53 .59 1SG2400
ATOM 2400 CD2 LEU 317 80 .652 36, .630 25, .117 1 .00 53 .59 1SG2401
ATOM 2401 CDl LEU 317 78, .236 35, .964 24 .609 1 .00 53 .59 1SG2402
ATOM 2402 C LEU 317 78 .080 33, .310 23. .331 1, .00 53, .59 1SG2403
ATOM 2403 O LEU 317 77 .348 34, .131 22. .778 1, .00 53 .59 1SG2404
ATOM 2404 N GLN 318 77 .597 32, .273 24, .053 1. .00 55 .28 1SG2405
ATOM 2405 CA GLN 318 76, .187 32, .112 24, .296 1, .00 55 .28 1SG2406
ATOM 2406 CB GLN 318 75, .608 30. .823 23. .691 1. .00 55, .28 1SG2407
ATOM 2407 CG GLN 318 75 .669 30, .714 22. .170 1 .00 55 .28 1SG2408
ATOM 2408 CD GLN 318 75 .078 29 .353 21, .823 1 .00 55 .28 1SG2409
ATOM 2409 OEl GLN 318 74 .023 29 .252 21 .201 1 .00 55 .28 1SG2410
ATOM 2410 NE2 GLN 318 75, .779 28, .270 22. .252 1, .00 55 .28 1SG2411
ATOM 2411 C GLN 318 76 .005 31, .934 25. .782 1, .00 55, .28 1SG2412
ATOM 2412 O GLN 318 76 .334 30, .877 26. .309 1, .00 55, .28 1SG2413
ATOM 2413 N PRO 319 75 .550 32, .949 26. .481 1, .00 55 .35 1SG2414
ATOM 2414 CA PRO 319 75, .331 32. .751 27. , 905 1. .00 55, .35 1SG2415
ATOM 2415 CD PRO 319 76, .197 34. .228 26. .224 1. .00 55. .35 1SG2416
ATOM 2416 CB PRO 319 75 .799 34, .035 28. .594 1. .00 55 .35 1SG2417
ATOM 2417 CG PRO 319 76 .739 34, .701 27, .579 1. .00 55. .35 1SG2418
ATOM 2418 C PRO 319 73, .913 32. .428 28. .331 1, .00 55, .35 1SG2419
ATOM 2419 O PRO 319 72, .986 32. .697 27. .568 1. .00 55. .35 1SG2420
ATOM 2420 N PHE 320 73 .727 31. .895 29. .569 1. .00 52. .54 1SG2421
ATOM 2421 CA PHE 320 72 .417 31. .786 30. .170 1. .00 52. .54 1SG2422
ATOM 2422 CB PHE 320 72, .154 30. .796 31. .342 1. .00 52. .54 1SG2423
ATOM 2423 CG PHE 320 71. .910 29. .331 31. ,166 1. .00 52. .54 1SG2424
ATOM 2424 CDl PHE 320 70, .808 28. .843 30. ,500 1. ,00 52. .54 1SG2425
ATOM 2425 CD2 PHE 320 72 .742 28. .434 31. .805 1. .00 52, .54 1SG2426
ATOM 2426 CE1 PHE' 320 70. .602 27. .486 30. .399 1. .00 52, .54 1SG2427
ATOM 2427 CE2 PHE 320 72, .542 27. .079 31. , 709 1. ,00 52. .54 1SG2428
ATOM 2428 CZ PHE 320 71. .468 26. .600 30. .998 1. .00 52. .54 1SG2429
ATOM 2429 C PHE 320 72. .396 32. .967 31. .080 1. .00 52. .54 1SG2430
ATOM 2430 O PHE 320 73. .356 33. ,193 31. ,816 1. .00 52. .54 1SG2431
ATOM 2431 N VAL 321 71. .304 33. ,743 31. 085 1. .00 46. .73 1SG2432
ATOM 2432 CA VAL 321 71. .239 34. 769 32. 078 1. .00 46. ,73 1SG2433
ATOM 2433 CB VAL 321 71. .188 36. ,158 31. 506 1. .00 46. .73 1SG2434 ATOM 2434 CGI VAL 321 71..011 37..146 32.,670 1.,00 46..73 1SG2435
ATOM 2435 CG2 VAL 321 72. .461 36. .407 30. .677 1. .00 46. .73 1SG2436
ATOM 2436 C VAL 321 69. .955 34. .516 32. .801 1. .00 46. ,73 1SG2437
ATOM 2437 O VAL 321 68. .883 34. .592 32. .207 1. .00 46. .73 1SG2438
ATOM 2438 N GLU 322 70. .030 34. .200 34. .110 1. ,00 41. .86 1SG2439
ATOM 2439 CA GLU 322 68. .829 33. .906 34. .840 1. .00 41. .86 1SG2440
ATOM 2440 CB GLU 322 68, .826 32. .532 35. .525 1. .00 41, .86 1SG2441
ATOM 2441 CG GLU 322 67. .494 32. .252 36. .224 1. .00 41. .86 1SG2442
ATOM 2442 CD GLU 322 67. .614 30. .977 37. .046 1. ,00 41. .86 1SG2443
ATOM 2443 OEl GLU 322 68. .467 30 .122 36. .704 1. .00 41. .86 1SG2444
ATOM 2444 OE2 GLU 322 66, .840 30. .844 38. .032 1. .00 41, .86 1SG2445
ATOM 2445 C GLU 322 68. .694 34. .902 35. .939 1. .00 41. .86 1SG2446
ATOM 2446 O GLU 322 69. .672 35. .263 36. .590 1. .00 41. .86 1SG2447
ATOM 2447 N VAL 323 67. .459 35. .372 36, .181 1. .00 38 .33 1SG2448
ATOM 2448 CA VAL 323 67, .264 36. .324 37, .229 1. .00 38, .33 1SG2449
ATOM 2449 CB VAL 323 66. .434 37. .488 36. .789 1. .00 38. .33 1SG2450
ATOM 2450 CGI VAL 323 67. .202 38, .242 35, .689 1. . 00 38. .33 1SG2451
ATOM 2451 CG2 VAL 323 65. .070 36, .947 36. .328 1. .00 38 .33 1SG2452
ATOM 2452 C VAL 323 66, .536 35, .637 38. .335 1. .00 38, .33 1SG2453
ATOM 2453 O VAL 323 65, .570 34 .909 38, .106 1. .00 38 .33 1SG2454
ATOM 2454 N LEU 324 67, .009 35, .842 39, .578 1. .00 35, .18 1SG2455
ATOM 2455 CA LEU 324 66. .382 35. .250 40. .721 1. .00 35, .18 1SG2456
ATOM 2456 CB LEU 324 67 .317 34 .350 41 .543 1 .00 35 .18 1SG2457
ATOM 2457 CG LEU 324 67 .763 33 .066 40. .829 1. .00 35 .18 1SG2458
ATOM 2458 CD2 LEU 324 66, .554 32. .233 40, .380 1. .00 35, .18 1SG2459
ATOM 2459 CDl LEU 324 68, .721 32 .256 41, .716 1. .00 35 .18 1SG2460
ATOM 2460 C LEU 324 66 .008 36 .362 41 .633 1, .00 35 .18 1SG2461
ATOM 2461 O LEU 324 66 .630 37 .423 41. .631 1, .00 35 .18 1SG2462
ATOM 2462 N ALA 325 64, .956 36 .133 42, .435 1. .00 34. .29 1SG2463
ATOM 2463 CA ALA 325 64. .565 37 .097 43 , .415 1, .00 34 .29 1SG2464
ATOM 2464 CB ALA 325 63, .040 37 .282 43 .521 1, .00 34 .29 1SG2465
ATOM 2465 C ALA 325 65, .041 36 .512 44, .699 1, .00 34, .29 1SG2466
ATOM 2466 O ALA 325 64 .842 35 .326 44, .954 1, .00 34 .29 1SG2467
ATOM 2467 N THR 326 65, .708 37 .319 45, .542 1. .00 36, .49 1SG2468
ATOM 2468 CA THR 326 66 . .179 36 .735 46, .757 1, .00 36 .49 1SG2469
ATOM 2469 CB THR 326 67 .565 37 .167 47 .161 1 .00 36 .49 1SG2470
ATOM 2470 OGl THR 326 68 .003 36 .407 48, .276 1, .00 36 .49 1SG2471
ATOM 2471 CG2 THR 326 67, .577 38, .670 47. .487 1. .00 36, .49 1SG2472
ATOM 2472 C THR 326 65 .207 37 .076 47, .835 1 .00 36 .49 1SG2473
ATOM 2473 O THR 326 64 .952 38 .241 48 .139 1. .00 36 .49 1SG2474
ATOM 2474 N ALA 327 64 .611 36 .029 48, .428 1. .00 38, .60 1SG2475
ATOM 2475 CA ALA 327 63 .648 36 .221 49 .467 1, .00 38, .60 1SG2476
ATOM 2476 CB ALA 327 62, .756 34 .993 49, .708 1. .00 38 .60 1SG2477
ATOM 2477 C ALA 327 64 .395 36 .525 50 .726 1. .00 38, .60 1SG2478
ATOM 2478 O ALA 327 65, .613 36, .374 50, .792 1. .00 38, .60 1SG2479
ATOM 2479 N SER 328 63 .670 36 .993 51, .758 1. .00 42, .49 1SG2480
ATOM 2480 CA SER 328 64, .272 37, .334 53, .016 1. .00 42. .49 1SG2481
ATOM 2481 CB SER 328 63, .265 37 .925 54, .014 1. .00 42. .49 1SG2482
ATOM 2482 OG SER 328 62 .767 39 .160 53 .521 1. .00 42 .49 1SG2483
ATOM 2483 C SER 328 64, .828 36 .076 53, .606 1. .00 42, .49 1SG2484
ATOM 2484 O SER 328 65, .687 36, .114 54 , .488 1. .00 42. .49 1SG2485
ATOM 2485 N ASN 329 64, .324 34 .927 53 .118 1 .00 48 .30 1SG2486
ATOM 2486 CA ASN 329 64 .718 33 .603 53, .516 1, .00 48. .30 1SG2487
ATOM 2487 CB ASN 329 63, .959 32, .498 52, .766 1. .00 48. .30 1SG2488
ATOM 2488 CG ASN 329 62, .485 32 .833 52, .762 1. .00 48. .30 1SG2489
ATOM 2489 OD1 ASN 329 62, .095 33, .773 52. .073 1. .00 48. .30 1SG2490
ATOM 2490 ND2 ASN 329 61, .655 32 .057 53, .507 1. .00 48. .30 1SG2491 ATOM 2491 C ASN 329 66..117 33..430 53..035 1..00 48..30 1SG2492
ATOM 2492 O ASN 329 66. .876 32. .617 53. .561 1, .00 48. .30 1SG2493
ATOM 2493 N SER 330 66. .474 34. .213 51, .999 1, .00 49. .67 1SG2494
ATOM 2494 CA SER 330 67. .705 34. .096 51. .276 1, .00 49, .67 1SG2495
ATOM 2495 CB SER 330 68, .921 33. .796 52. .169 1. .00 49, .67 1SG2496
ATOM 2496 OG SER 330 70, .093 33. .692 51. .376 ' 1. .00 49, .67 1SG2497
ATOM 2497 C SER 330 67, .543 32, .973 50. .304 1, .00 49, .67 1SG2498
ATOM 2498 O SER 330 68, .495 32, .571 49. .638 1, .00 49, .67 1SG2499
ATOM 2499 N ALA 331 66. .302 32, .464 50, .166 1. .00 49. .20 1SG2500
ATOM 2500 CA ALA 331 66. .041 31, .458 49, .180 1. .00 49. .20 1SG2501
ATOM 2501 CB ALA 331 64, .684 30, .759 49, .370 1, .00 49. .20 1SG2502
ATOM 2502 C ALA 331 66 .017 32 .172 47 .863 1 .00 49 .20 1SG2503
ATOM 2503 O ALA 331 65 .742 33 .370 47 .810 1 .00 49 .20 1SG2504
ATOM 2504 N PHE 332 66 .329 31 .461 46 .758 1 .00 48 .59 1SG2505
ATOM 2505 CA PHE 332 66 .341 32 .100 45 .471 1 .00 48 .59 1SG2506
ATOM 2506 CB PHE 332 67 .638 31 .819 44 .678 1 .00 48 .59 1SG2507
ATOM 2507 CG PHE 332 67 .805 30, .342 44 .525 1 .00 48 .59 1SG2508
ATOM 2508 CDl PHE 332 68 .474 29, .618 45 .486 1 .00 48 .59 1SG2509
ATOM 2509 CD2 PHE 332 67 .300 29 .676 43 .431 1 .00 48 .59 1SG2510
ATOM 2510 CE1 PHE 332 68 .633 28 .258 45 .361 1 .00 48 .59 1SG2511
ATOM 2511 CE2 PHE 332 67 .455 28 .315 43 .300 1 .00 48 .59 1SG2512
ATOM 2512 CZ PHE 332 68 .125 27 .602 44 .265 1 .00 48 .59 1SG2513
ATOM 2513 C PHE 332 65, .166 31, .614 44 .680 1 .00 48 .59 1SG2514
ATOM 2514 O PHE 332 64, .922 30 .412 44 .583 1 .00 48 .59 1SG2515
ATOM 2515 N GLN 333 64, .379 32, .551 44 .106 1 .00 46 .31 1SG2516
ATOM 2516 CA GLN 333 63, .261 32, .136 43 .308 1 .00 46 .31 1SG2517
ATOM 2517 CB GLN 333 61 .893 32 .635 43 .804 1 .00 46 .31 1SG2518
ATOM 2518 CG GLN 333 61 .438 31, .895 45 .063 1 .00 46 .31 1SG2519
ATOM 2519 CD GLN 333 61 .285 30, .421 44 .698 1 .00 46 .31 1SG2520
ATOM 2520 OEl GLN 333 61 .513 30, .028 43 .555 1 .00 46 .31 1SG2521
ATOM 2521 NE2 GLN 333 60 .892 29, .579 45 .692 1 .00 46 .31 1SG2522
ATOM 2522 C GLN 333 63, .480 32, .617 41 .911 1 .00 46, .31 1SG2523
ATOM 2523 O GLN 333 63 .712 33, .801 41 .675 1 .00 46, .31 1SG2524
ATOM 2524 N SER 334 63, .415 31, .676 40 .946 1 .00 44, .09 1SG2525
ATOM 2525 CA SER 334 63, .701 31, .957 39 .567 1 .00 44, .09 1SG2526
ATOM 2526 CB SER 334 63, .833 30, .674 38 .725 1, .00 44, .09 1SG2527
ATOM 2527 OG SER 334 64, .115 30, .988 37 .370 1 .00 44, .09 1SG2528
ATOM 2528 C SER 334 62, .632 32, .802 38, .946 1, .00 44, .09 1SG2529
ATOM 2529 O SER 334 61, .479 32, .386 38 .846 1, .00 44, .09 1SG2530
ATOM 2530 N LEU 335 62, .994 34, .043 38 .551 1. .00 43. .60 1SG2531
ATOM 2531 CA LEU 335 62. .081 34. .911 37, .866 1, .00 43, .60 1SG2532
ATOM 2532 CB LEU 335 62, .538 36. .378 37, .909 1, .00 43, .60 1SG2533
ATOM 2533 CG LEU 335 62 , .667 36. .928 39, .346 1, .00 43 , .60 1SG2534
ATOM 2534 CD2 LEU 335 61, .421 36. .617 40, .194 1, .00 43 , .60 1SG2535
ATOM 2535 CDl LEU 335 63. .032 38. .421 39, .339 1, .00 43. .60 1SG2536
ATOM 2536 C LEU 335 61. .928 34. .502 36, .424 1, .00 43. .60 1SG2537
ATOM 2537 O LEU 335 60. .820 34. .241 35, .958 1, .00 43. .60 1SG2538
ATOM 2538 N PHE 336 63. .058 34. .408 35. .681 1. .00 41. .50 1SG2539
ATOM 2539 CA PHE 336 63. .010 34. .063 34. .282 1, .00 41. .50 1SG2540
ATOM 2540 CB PHE 336 62. .426 35. .177 33, .389 1, .00 41. .50 1SG2541
ATOM 2541 CG PHE 336 63. .191 36. .442 33 , .601 1, .00 41. .50 1SG2542
ATOM 2542 CDl PHE 336 64. .417 36. .644 33 , .011 1, .00 41. .50 1SG2543
ATOM 2543 CD2 PHE 336 62. .663 37. .443 34. .386 1. .00 41. .50 1SG2544
ATOM 2544 CE1 PHE 336 65. .108 37. .817 33. .210 1. .00 41. .50 1SG2545
ATOM 2545 CE2 PHE 336 63. ,348 38. .618 34. .589 1. .00 41. .50 1SG2546
ATOM 2546 CZ PHE 336 64. ,576 38. ,806 34. .001 1. .00 41. .50 1SG2547
ATOM 2547 C PHE 336 64. .388 33. .724 33. .784 1. .00 41. .50 1SG2548 ATOM 2548 O PHE 336 65..392 34..064 34..408 1..00 41..50 1SG2549
ATOM 2549 N SER 337 64. .463 33. .028 32. .626 1. ,00 38. .46 1SG2550
ATOM 2550 CA SER 337 65. .732 32. .643 32. .066 1. .00 38. .46 1SG2551
ATOM 2551 CB SER 337 65. .861 31. .126 31. ,838 1. .00 38. .46 1SG2552
ATOM 2552 OG SER 337 65. .791 30. .433 33. .076 1. .00 38. .46 1SG2553
ATOM 2553 C SER 337 65, .872 33 , .310 30, .729 1. .00 38. .46 1SG2554
ATOM 2554 O SER 337 64. .937 33. .337 29. .932 1. .00 38. .46 1SG2555
ATOM 2555 N LEU 338 67. .067 33. .873 30. .457 1. .00 37. .57 1SG2556
ATOM 2556 CA LEU 338 67, .309 34. .577 29. .231 1. .00 37, .57 1SG2557
ATOM 2557 CB LEU 338 67, .755 36, .036 29. .454 1. .00 37, .57 1SG2558
ATOM 2558 CG LEU 338 68. .018 36. .824 28. .157 1. .00 37. .57 1SG2559
ATOM 2559 CD2 LEU 338 68. .740 38. .152 28, .443 1. .00 37, .57 1SG2560
ATOM 2560 CDl LEU 338 66, .727 37. .016 27, .349 1. .00 37, .57 1SG2561
ATOM 2561 C LEU 338 68, .419 33. .895 28. .502 1. .00 37, .57 1SG2562
ATOM 2562 O LEU 338 69, .364 33. .392 29. .108 1. .00 37, .57 1SG2563
ATOM 2563 N ASP 339 68, .314 33, .853 27. .159 1. .00 35 .94 1SG2564
ATOM 2564 CA ASP 339 69, .348 33. .265 26. .360 1. .00 35, .94 1SG2565
ATOM 2565 CB ASP 339 68, .818 32, .257 25. .322 1, .00 35 .94 1SG2566
ATOM 2566 CG ASP 339 69 .999 31, .510 24, .714 1. .00 35 .94 1SG2567
ATOM 2567 ODl ASP 339 71, .036 32. .163 24. .425 1. .00 35 .94 1SG2568
ATOM 2568 OD2 ASP 339 69, .881 30. .266 24. .543 1. .00 35 .94 1SG2569
ATOM 2569 C ASP 339 69, .981 34, .397 25. .620 1. .00 35 .94 1SG2570
ATOM 2570 O ASP 339 69, .328 35. .088 24. .839 1. .00 35 .94 1SG2571
ATOM 2571 N VAL 340 71, .281 34, .626 25, .867 1, .00 35 .82 1SG2572
ATOM 2572 CA VAL 340 71 .957 35, .713 25, .229 1. .00 35 .82 1SG2573
ATOM 2573 CB VAL 340 72 .631 36, .623 26, .213 1 .00 35 .82 1SG2574
ATOM 2574 CGI VAL 340 73. .453 37, .668 25, .445 1, .00 35 .82 1SG2575
ATOM 2575 CG2 VAL 340 71. .564 37, .212 27, .149 1. .00 35 .82 1SG2576
ATOM 2576 C VAL 340 73 .035 35, .142 24 .370 1 .00 35 .82 1SG2577
ATOM 2577 O VAL 340 73, .694 34, .172 24, .743 1, .00 35 .82 1SG2578
ATOM 2578 N VAL 341 73, .219 35, .730 23, .174 1. .00 38 .87 1SG2579
ATOM 2579 CA VAL 341 74 .269 35, .330 22 .285 1 .00 38 .87 1SG2580
ATOM 2580 CB VAL 341 73, .845 34. .317 21, .260 1, .00 38 .87 1SG2581
ATOM 2581 CGI VAL 341 72, .700 34. .904 20, .419 1. .00 38 .87 1SG2582
ATOM 2582 CG2 VAL 341 75 .080 33. .928 20, .429 1 .00 38 .87 1SG2583
ATOM 2583 C VAL 341 74, .683 36. .571 21. .566 1, .00 38 .87 1SG2584
ATOM 2584 O VAL 341 73, .877 37, .482 21. .382 1. .00 38 .87 1SG2585
ATOM 2585 N VAL 342 75 .964 36, .653 21. .154 1. .00 41 .62 1SG2586
ATOM 2586 CA VAL 342 76 .415 37 .842 20, .491 1 .00 41 .62 1SG2587
ATOM 2587 CB VAL 342 76, .863 38. .918 21, .438 1, .00 41 .62 1SG2588
ATOM 2588 CGI VAL 342 75, .657 39. .370 22, .278 1, .00 41 .62 1SG2589
ATOM 2589 CG2 VAL 342 78 .033 38. .371 22, .274 1. .00 41 .62 1SG2590
ATOM 2590 C VAL 342 77, .599 37. .493 19, .646 1. .00 41, .62 1SG2591
ATOM 2591 O VAL 342 77, .969 36. .327 19. .529 1, .00 41, .62 1SG2592
ATOM 2592 N ASN 343 78 .193 38, .526 19. .007 1, .00 44 .72 1SG2593
ATOM 2593 CA ASN 343 79, .364 38. .416 18. .180 1. .00 44, .72 1SG2594
ATOM 2594 CB ASN 343 79, .129 38. .934 16. .749 1, .00 44, .72 1SG2595
ATOM 2595 CG ASN 343 80 .289 38, .532 15. .848 1, .00 44 .72 1SG2596
ATOM 2596 ODl ASN 343 81, .460 38. .602 16. .217 1. .00 44, .72 1SG2597
ATOM 2597 ND2 ASN 343 79, .947 38, .095 14, .606 1. .00 44, .72 1SG2598
ATOM 2598 C ASN 343 80, .379 39. .314 18, .825 1. .00 44, .72 1SG2599
ATOM 2599 O ASN 343 80, .029 40. .365 19, .359 1, .00 44 .72 1SG2600
ATOM 2600 N LEU 344 81, .665 38. .911 18. .809 1. .00 47, .69 1SG2601
ATOM 2601 CA LEU 344 82, .696 39. .624 19, .513 1, .00 47, .69 1SG2602
ATOM 2602 CB LEU 344 83, .015 38. .832 20, .806 1, .00 47 .69 1SG2603
ATOM 2603 CG LEU 344 84, .151 39. .300 21. .737 1. .00 47, .69 1SG2604
ATOM 2604 CD2 LEU 344 83, .889 40. .686 22. .339 1. .00 47, .69 1SG2605 ATOM 2605 CDl LEU 344 85..520 39..148 21..068 1..00 47..69 1SG2606
ATOM 2606 C LEU 344 83. ,923 39. .693 18. .647 1. ,00 47. .69 1SG2607
ATOM 2607 O LEU 344 84. ,156 38. .821 17. .813 1. ,00 47. ,69 1SG2608
ATOM 2608 N ARG 345 84. .740 40, .755 18. .826 1. .00 47. .62 1SG2609
ATOM 2609 CA ARG 345 85. .963 40, .930 18. .087 1. .00 47. .62 1SG2610
ATOM 2610 CB ARG 345 86. .189 42. .391 17. .660 1. .00 47. .62 1SG2611
ATOM 2611 CG ARG 345 87. .551. 42. .666 17, .020 1, .00 47. .62 1SG2612
ATOM 2612 CD ARG 345 87. .697 42. .146 15, .590 1. .00 47. .62 1SG2613
ATOM 2613 NE ARG 345 89. .048 42. .558 15. .114 1. .00 47. .62 1SG2614
ATOM 2614 CZ ARG 345 89. .239 43. .813 14. .612 1. .00 47. .62 1SG2615
ATOM 2615 NHl ARG 345 88. .193 44. .688 14. .546 1. .00 47. .62 1SG2616
ATOM 2616 NH2 ARG 345 90. .477 44, .198 14. .185 1. .00 47. .62 1SG2617
ATOM 2617 C ARG 345 87. .074 40. .585 19. .021 1. .00 47. .62 1SG2618
ATOM 2618 O ARG 345 87. .152 41. .133 20. .120 1. .00 47. .62 1SG2619
ATOM 2619 N LEU 346 87, .964 39. .654 18. .615 1. .00 46. .43 1SG2620
ATOM 2620 CA LEU 346 89. .019 39. .266 19. .504 1. .00 46. .43 1SG2621
ATOM 2621 CB LEU 346 89. .121 37. .731 19. .665 1, .00 46. .43 1SG2622
ATOM 2622 CG LEU 346 90, .062 37, .206 20. .779 1. .00 46, .43 1SG2623
ATOM 2623 CD2 LEU 346 91, .493 37. .755 20. .681 1. .00 46, .43 1SG2624
ATOM 2624 CDl LEU 346 90 .045 35 .669 20 .811 1, .00 46 .43 1SG2625
ATOM 2625 C LEU 346 90, .300 39. .779 18. .923 1. .00 46, .43 1SG2626
ATOM 2626 O LEU 346 90, .693 39, .403 17, .820 1. .00 46, .43 1SG2627
ATOM 2627 N GLN 347 90, .983 40 .661 19 .673 1, .00 43 .58 1SG2628
ATOM 2628 CA GLN 347 92. .238 41, .197 19, .231 1, .00 43, .58 1SG2629
ATOM 2629 CB GLN 347 92, .454 42, .659 19, .658 1, .00 43, .58 1SG2630
ATOM 2630 CG GLN 347 93, .790 43, .242 19, .197 1. .00 43, .58 1SG2631
ATOM 2631 CD GLN 347 93 .736 43 .449 17 .691 1. .00 43 .58 1SG2632
ATOM 2632 OEl GLN 347 92, .706 43, .235 17, .053 1. .00 43, .58 1SG2633
ATOM 2633 NE2 GLN 347 94, .881 43 , .881 17, .099 1. .00 43, .58 1SG2634
ATOM 2634 C GLN 347 93 .311 40 .375 19 .868 1 .00 43 .58 1SG2635
ATOM 2635 O GLN 347 93 .162 39 .917 21 .000 1. .00 43 .58 1SG2636
ATOM 2636 N LEU 348 94, .426 40, .150 19 .143 1. .00 39, .44 1SG2637
ATOM 2637 CA LEU 348 95 .486 39 .354 19 .690 1 .00 39 .44 1SG2638
ATOM 2638 CB LEU 348 95 .699 38 .040 18 .906 1, .00 39 .44 1SG2639
ATOM 2639 CG LEU 348 96, .758 37, .069 19 .476 1, .00 39, .44 1SG2640
ATOM 2640 CD2 LEU 348 96 .402 36 .644 20 .909 1 .00 39 .44 1SG2641
ATOM 2641 CDl LEU 348 98 .193 37 .607 19 .344 1, .00 39 .44 1SG2642
ATOM 2642 C LEU 348 96, .753 40, .152 19 .624 1. .00 39, .44 1SG2643
ATOM 2643 O LEU 348 97, .023 40. .840 18, .640 1, .00 39. .44 1SG2644
ATOM 2644 N SER 349 97 .569 40 .071 20 .693 1 .00 36. .38 1SG2645
ATOM 2645 CA SER 349 98, .821 40 .771 20, .746 1, .00 36. .38 1SG2646
ATOM 2646 CB SER 349 98, .706 42. .168 21, .374 1, .00 36, .38 1SG2647
ATOM 2647 OG SER 349 98 .213 42 .061 22 .700 1 .00 36, .38 1SG2648
ATOM 2648 C SER 349 99, .738 39 .956 21, .604 1, .00 36, .38 1SG2649
ATOM 2649 O SER 349 99, .315 38, .977 22. .215 1, .00 36, .38 1SG2650
ATOM 2650 N VAL 350 101 .036 40 .320 21 .654 1, .00 34, .24 1SG2651
ATOM 2651 CA VAL 350 101, .928 39, .540 22 .461 1, .00 34. .24 1SG2652
ATOM 2652 CB VAL 350 102, .882 38, .708 21, .659 1, .00 34. .24 1SG2653
ATOM 2653 CGI VAL 350 103 .865 38 .021 22 .623 1, .00 34. .24 1SG2654
ATOM 2654 CG2 VAL 350 102, .069 37, .729 20, .793 1, .00 34, .24 1SG2655
ATOM 2655 C VAL 350 102, .752 40, .445 23, .318 1, .00 34, .24 1SG2656
ATOM 2656 O VAL 350 103 .175 41, .521 22 .899 1, .00 34, .24 1SG2657
ATOM 2657 N SER 351 102, .992 40, .010 24, .571 1, .00 34. .84 1SG2658
ATOM 2658 CA SER 351 103, .836 40, .722 25, .482 1. .00 34. .84 1SG2659
ATOM 2659 CB SER 351 103. .076 41. .412 26. .626 1. .00 34. .84 1SG2660
ATOM 2660 OG SER 351 103. .987 42. .087 27. .481 1. .00 34, .84 1SG2661
ATOM 2661 C SER 351 104. .703 39. .673 26. .092 1. .00 34. .84 1SG2662 ATOM 2662 0 SER 351 104..216 38..590 26..412 1..00 34..84 1SG2663
ATOM 2663 N LYS 352 106, .010 39. ,963 26, .267 1. .00 36. .43 1SG2664
ATOM 2664 CA LYS 352 106, .868 38. .947 26, .806 1, .00 36, .43 1SG2665
ATOM 2665 CB LYS 352 106, .431 38, .457 28, .197 1. .00 36. .43 1SG2666
ATOM 2666 CG LYS 352 107, .469 37. ,585 28. .906 1. .00 36. .43 1SG2667
ATOM 2667 CD LYS 352 108, .705 38. .364 29. .363 1. .00 36, .43 1SG2668
ATOM 2668 CE LYS 352 109 .719 37. ,515 30 .131 1, .00 36 .43 1SG2669
ATOM 2669 NZ LYS 352 110. .875 38, .349 30. .530 1. .00 36, .43 1SG2670
ATOM 2670 C LYS 352 106. .769 37. .812 25 .843 1. .00 36, .43 1SG2671
ATOM 2671 O LYS 352 106, .801 38. .018 24. .630 1. .00 36, .43 1SG2672
ATOM 2672 N VAL 353 106 .685 36. .570 26 .356 1, .00 36 .54 1SG2673
ATOM 2673 CA VAL 353 106, .435 35. .488 25, .454 1. .00 36, .54 1SG2674
ATOM 2674 CB VAL 353 107, .429 34, .371 25 .579 1, .00 36 .54 1SG2675
ATOM 2675 CGI VAL 353 107, .027 33. .240 24, .616 1. .00 36. .54 1SG2676
ATOM 2676 CG2 VAL 353 108, .835 34, .938 25 .319 1, .00 36 .54 1SG2677
ATOM 2677 C VAL 353 105, .097 34. .951 25, .849 1. .00 36. .54 1SG2678
ATOM 2678 O VAL 353 104, .986 33. .833 26, .352 1, .00 36 .54 1SG2679
ATOM 2679 N LYS 354 104, .031 35. .741 25, .610 1. .00 35, .78 1SG2680
ATOM 2680 CA LYS 354 102, .716 35. .303 25, .976 1. .00 35 .78 1SG2681
ATOM 2681 CB LYS 354 102, .182 35. .908 27. .288 1. .00 35, .78 1SG2682
ATOM 2682 CG LYS 354 102, .903 35, .415 28. .545 1. .00 35 .78 1SG2683
ATOM 2683 CD LYS 354 102, .479 36, .150 29, .820 1, .00 35 .78 1SG2684
ATOM 2684 CE LYS 354 102, .985 37, .591 29, .906 1. .00 35 .78 1SG2685
ATOM 2685 NZ LYS 354 104 , .443 37. .600 30, .154 1. .00 35, .78 1SG2686
ATOM 2686 C LYS 354 101, .777 35, .726 24, .897 1, .00 35 .78 1SG2687
ATOM 2687 O LYS 354 102 , .032 36. .686 24. .173 1. .00 35 .78 1SG2688
ATOM 2688 N LEU 355 100, .661 34. .986 24. .758 1, .00 34. .02 1SG2689
ATOM 2689 CA LEU 355 99 .674 35, .320 23 .778 1, .00 34, .02 1SG2690
ATOM 2690 CB LEU 355 99, .143 34. .076 23, .034 1, .00 34. .02 1SG2691
ATOM 2691 CG LEU 355 98, .201 34. .367 21, .849 1, .00 34 .02 1SG2692
ATOM 2692 CD2 LEU 355 97, .517 33. .085 21, .345 1, .00 34. .02 1SG2693
ATOM 2693 CDl LEU 355 98 .942 35. .111 20 .727 1, .00 34 .02 1SG2694
ATOM 2694 C LEU 355 98, .548 35. .932 24. .553 1. .00 34. .02 1SG2695
ATOM 2695 O LEU 355 97. .920 35. .271 25 .377 1. .00 34. .02 1SG2696
ATOM 2696 N GLN 356 98. .278 37. .232 24, .313 1. .00 33, .89 1SG2697
ATOM 2697 CA GLN 356 97. .250 37. .912 25 .048 1, .00 33. .89 1SG2698
ATOM 2698 CB GLN 356 97, .765 39. .151 25, .803 1. .00 33. .89 1SG2699
ATOM 2699 CG GLN 356 96. .684 39, .896 26 .588 1. .00 33, .89 1SG2700
ATOM 2700 CD GLN 356 97. .346 41. .085 27, .270 1. .00 33. .89 1SG2701
ATOM 2701 OEl GLN 356 98, .565 41. .239 27. .226 1. .00 33. .89 1SG2702
ATOM 2702 NE2 GLN 356 96. .523 41. .954 27, .916 1. .00 33. .89 1SG2703
ATOM 2703 C GLN 356 96. .248 38, .397 24, .058 1. .00 33. .89 1SG2704
ATOM 2704 O GLN 356 96. .548 38. .554 22. .877 1. .00 33. .89 1SG2705
ATOM 2705 N GLY 357 95. .008 38, .632 24. .521 1. .00 34. .88 1SG2706
ATOM 2706 CA GLY 357 94. .021 39. .107 23. .605 1. .00 34. .88 1SG2707
ATOM 2707 C GLY 357 92. .951 39. .750 24, .402 1. .00 34. .88 1SG2708
ATOM 2708 O GLY 357 92. .891 39. .604 25. .620 1. .00 34. .88 1SG2709
ATOM 2709 N THR 358 92. .075 40. .510 23. .728 1. .00 40. .31 1SG2710
ATOM 2710 CA THR 358 91. .018 41. .102 24. .475 1. .00 40. .31 1SG2711
ATOM 2711 CB THR 358 91, .218 42. .566 24. .739 1. .00 40. .31 1SG2712
ATOM 2712 OGl THR 358 91. .250 43. .286 23. .515 1. .00 40. .31 1SG2713
ATOM 2713 CG2 THR 358 92. .542 42. .753 25. .500 1. ,00 40. ,31 1SG2714
ATOM 2714 C THR 358 89. .781 40. ,969 23. .672 1. ,00 40. ,31 1SG2715
ATOM 2715 0 THR 358 89. .813 41. .096 22. .447 1. ,00 40. .31 1SG2716
ATOM 2716 N THR 359 88. .652 40. .679 24. .345 1. .00 45. .40 1SG2717
ATOM 2717 CA THR 359 87. .442 40. .754 23. .605 1. .00 45. .40 1SG2718
ATOM 2718 CB THR 359 86. ,240 40. ,173 24. .308 1. ,00 45. .40 1SG2719 ATOM 2719 OGl THR 359 86..013 40..804 25,.560 1..00 45..40 1SG2720
ATOM 2720 CG2 THR 359 86. .482 38. .668 24, .511 1. .00 45. .40 1SG2721
ATOM 2721 C THR 359 87. .325 42. .224 23, .471 1. .00 45. .40 1SG2722
ATOM 2722 O THR 359 86. .894 42. .917 24, .396 1. .00 45. .40 1SG2723
ATOM 2723 N SER 360 87. .778 42. .723 22, .305 1. .00 45. .94 1SG2724
ATOM 2724 CA SER 360 87. .854 44. .127 22, .084 1. .00 45. .94 1SG2725
ATOM 2725 CB SER 360 88, .249 44. .491 20, .644 1. .00 45, .94 1SG2726
ATOM 2726 OG SER 360 88, .306 45. .902 20, .495 1. .00 45, .94 1SG2727
ATOM 2727 C SER 360 86, .495 44. .629 22, .317 1, .00 45, .94 1SG2728
ATOM 2728 O SER 360 86, .289 45. .523 23, .136 1, .00 45, .94 1SG2729
ATOM 2729 N VAL 361 85, .516 44. .014 21, .639 1. .00 45, .85 1SG2730
ATOM 2730 CA VAL 361 84. .211 44. .516 21, .879 1. .00 45. .85 1SG2731
ATOM 2731 CB VAL 361 83. .841 45. .710 21, .039 1. .00 45. .85 1SG2732
ATOM 2732 CGI VAL 361 84. .742 46. ,913 21, .366 1. .00 45. .85 1SG2733
ATOM 2733 CG2 VAL 361 83. .896 45. ,280 19. .563 1. .00 45. .85 1SG2734
ATOM 2734 C VAL 361 83, .204 43. .501 21. .498 1. .00 45, .85 1SG2735
ATOM 2735 O VAL 361 83, .390 42. .711 20. .572 1. .00 45. .85 1SG2736
ATOM 2736 N LEU 362 82. .080 43. ,538 22, .228 1. .00 39. .34 1SG2737
ATOM 2737 CA LEU 362 80, .958 42. .725 21, .908 1. .00 39, .34 1SG2738
ATOM 2738 CB LEU 362 80, .070 42. .390 23, .118 1. .00 39, .34 1SG2739
ATOM 2739 CG LEU 362 80, .795 41. .617 24, .234 1. .00 39, .34 1SG2740
ATOM 2740 CD2 LEU 362 81, .930 42. .454 24, .838 1. .00 39, .34 1SG2741
ATOM 2741 CDl LEU 362 81, .264 40. .235 23. .757 1. .00 39, .34 1SG2742
ATOM 2742 C LEU 362 80, .138 43. .565 20. .989 1. .00 39, .34 1SG2743
ATOM 2743 O LEU 362 80, .270 44. .789 20. .973 1. .00 39, .34 1SG2744
ATOM 2744 N GLY 363 79, .280 42. .925 20. .179 1, .00 32, .95 1SG2745
ATOM 2745 CA GLY 363 78, .434 43. .664 19. .295 1. .00 32, .95 1SG2746
ATOM 2746 C GLY 363 77, .132 43. .815 20. .003 1. .00 32, .95 1SG2747
ATOM 2747 O GLY 363 77, .081 43. .837 21. .232 1. .00 32, .95 1SG2748
ATOM 2748 N ASP 364 76, .034 43. .928 19. .235 1. .00 31, .54 1SG2749
ATOM 2749 CA ASP 364 74, .756 44. .060 19, .859 1. .00 31, .54 1SG2750
ATOM 2750 CB ASP 364 73, .614 44. .339 18, .867 1. .00 31, .54 1SG2751
ATOM 2751 CG ASP 364 73, .836 45. .724 18, .275 1. .00 31, .54 1SG2752
ATOM 2752 ODl ASP 364 74, .762 46, .432 18, .753 1, .00 31, .54 1SG2753
ATOM 2753 OD2 ASP 364 73, .081 46. .091 17, .336 1. .00 31, .54 1SG2754
ATOM 2754 C ASP 364 74, .479 42. .754 20, .526 1. .00 31, .54 1SG2755
ATOM 2755 O ASP 364 74, .987 41. .714 20, .111 1. .00 31, .54 1SG2756
ATOM 2756 N VAL 365 73, .674 42, .782 21, .605 1, .00 31, .60 1SG2757
ATOM 2757 CA VAL 365 73, .374 41. .581 22, .324 1. .00 31, .60 1SG2758
ATOM 2758 CB VAL 365 73, .379 41. .787 23 .812 1. .00 31, .60 1SG2759
ATOM 2759 CGI VAL 365 72, .330 42. .857 24 .164 1. .00 31, .60 1SG2760
ATOM 2760 CG2 VAL 365 73, .121 40. .438 24, .498 1. .00 31, .60 1SG2761
ATOM 2761 C VAL 365 71, .996 41. .167 21. .935 1. .00 31, .60 1SG2762
ATOM 2762 O VAL 365 71, .090 41, .994 21 .860 1. .00 31. .60 1SG2763
ATOM 2763 N GLN 366 71, .801 39. .865 21 .652 1. .00 34. .96 1SG2764
ATOM 2764 CA GLN 366 70, .475 39. .460 21, .308 1. .00 34. .96 1SG2765
ATOM 2765 CB GLN 366 70, .344 38. .663 20, .000 1. .00 34. .96 1SG2766
ATOM 2766 CG GLN 366 71, .029 37. .301 20. .015 1. .00 34. .96 1SG2767
ATOM 2767 CD GLN 366 70, .777 36. .665 18, .657 1. .00 34. .96 1SG2768
ATOM 2768 OEl GLN 366 70, .464 35. .480 18 .563 1. .00 34. .96 1SG2769
ATOM 2769 NE2 GLN 366 70, .914 37. .475 17, .572 1. .00 34. .96 1SG2770
ATOM 2770 C GLN 366 69, .970 38. .629 22, .430 1. .00 34. .96 1SG2771
ATOM 2771 O GLN 366 70, .678 37. .788 22, .984 1. .00 34. .96 1SG2772
ATOM 2772 N LEU 367 68, .708 38. .877 22 .809 1. .00 36. .98 1SG2773
ATOM 2773 CA LEU 367 68, .154 38. .208 23, .935 1. .00 36. .98 1SG2774
ATOM 2774 CB LEU 367 67, .668 39. .230 24, .968 1. .00 36. .98 1SG2775
ATOM 2775 CG LEU 367 68. .827 40. .168 25. .361 1. .00 36. .98 1SG2776 ATOM 2776 CD2 LEU 367 70..054 39..368 25..818 1..00 36,.98 1SG2777
ATOM 2777 CDl LEU 367 68. .409 41. .215 26. .390 1. .00 36, .98 1SG2778
ATOM 2778 C LEU 367 67. .012 37. .385 23. .454 1. .00 36, .98 1SG2779
ATOM 2779 O LEU 367 66, .382 37. .703 22. .447 1. .00 36, .98 1SG2780
ATOM 2780 N THR 368 66. .763 36. .257 24. .142 1. .00 36, .09 1SG2781
ATOM 2781 CA THR 368 65 .651 35. .419 23. .814 1. .00 36, .09 1SG2782
ATOM 2782 CB THR 368 66 .024 34, .217 23. .000 1, .00 36, .09 1SG2783
ATOM 2783 OGl THR 368 66 .634 34, .621 21. .783 1, .00 36 .09 1SG2784
ATOM 2784 CG2 THR 368 64. .747 33, .412 22, .709 1. .00 36 .09 1SG2785
ATOM 2785 C THR 368 65, .118 34, .936 25, .122 1. .00 36, .09 1SG2786
ATOM 2786 O THR 368 65, .881 34, .742 26. .067 1. .00 36, .09 1SG2787
ATOM 2787 N VAL 369 63. .790 34, .736 25, .229 1, .00 34, .91 1SG2788
ATOM 2788 CA VAL 369 63. .293 34. .280 26, .494 1. .00 34, .91 1SG2789
ATOM 2789 CB VAL 369 62. .045 34. .975 26. .957 1. .00 34, .91 1SG2790
ATOM 2790 CGI VAL 369 62. .398 36. .437 27. .276 1. .00 34, .91 1SG2791
ATOM 2791 CG2 VAL 369 60. .957 34. .819 25. .880 1. .00 34, .91 1SG2792
ATOM 2792 C VAL 369 63, .008 32. .816 26. .402 1. .00 34, .91 1SG2793
ATOM 2793 O VAL 369 62 .181 32. .379 25 .602 1, .00 34 .91 1SG2794
ATOM 2794 N ALA 370 63 .758 32. .012 27. .185 1, .00 32 .17 1SG2795
ATOM 2795 CA ALA 370 63 .551 30. .593 27. .223 1, .00 32 .17 1SG2796
ATOM 2796 CB ALA 370 64 .681 29, .845 27. .949 1, .00 32 .17 1SG2797
ATOM 2797 C ALA 370 62, .272 30, .272 27. .928 1, .00 32 .17 1SG2798
ATOM 2798 O ALA 370 61, .447 29, .511 27, .425 1, .00 32 .17 1SG2799
ATOM 2799 N SER 371 62. .070 30. .863 29, .126 1, .00 33 .08 1SG2800
ATOM 2800 CA SER 371 60, .888 30. .586 29, .890 1, .00 33, .08 1SG2801
ATOM 2801 CB SER 371 60, .894 29. .198 30, .549 1, .00 33, .08 1SG2802
ATOM 2802 OG SER 371 59, .694 29. .004 31. .283 1, .00 33, .08 1SG2803
ATOM 2803 C SER 371 60, .812 31. .599 30. .985 1, .00 33, .08 1SG2804
ATOM 2804 O SER 371 61 .820 32. .196 31. .359 1 .00 33 .08 1SG2805
ATOM 2805 N SER 372 59 .601 31. .825 31, .527 1, .00 34 .01 1SG2806
ATOM 2806 CA SER 372 59 .491 32, .802 32, .566 1, .00 34 .01 1SG2807
ATOM 2807 CB SER 372 59 .048 34. .176 32, .040 1, .00 34 .01 1SG2808
ATOM 2808 OG SER 372 58, .947 35. .097 33, .112 1, .00 34 .01 1SG2809
ATOM 2809 C SER 372 58, .464 32. .348 33. .549 1, .00 34, .01 1SG2810
ATOM 2810 O SER 372 57, .392 31. .875 33. .178 1. .00 34, .01 1SG2811
ATOM 2811 N ASN 373 58, .798 32. .455 34. .850 1. .00 35, .18 1SG2812
ATOM 2812 CA ASN 373 57. .884 32. .116 35. .898 1, .00 35, .18 1SG2813
ATOM 2813 CB ASN 373 58. .581 31. .951 37. .259 1, .00 35, .18 1SG2814
ATOM 2814 CG ASN 373 59. .460 30. .711 37. .154 1. .00 35, .18 1SG2815
ATOM 2815 ODl ASN 373 59. .655 30. .169 36, .066 1, .00 35 .18 1SG2816
ATOM 2816 ND2 ASN 373 59. .995 30. .240 38, .312 1, .00 35, .18 1SG2817
ATOM 2817 C ASN 373 56, .851 33. .198 36, .006 1, .00 35, .18 1SG2818
ATOM 2818 O ASN 373 55, .684 32. .935 36, .291 1, .00 35, .18 1SG2819
ATOM 2819 N VAL 374 57, .280 34. .460 35, .797 1. .00 38, .68 1SG2820
ATOM 2820 CA VAL 374 56. .441 35. .621 35. .928 1. .00 38, .68 1SG2821
ATOM 2821 CB VAL 374 57. .185 36. .929 35. .933 1. .00 38. .68 1SG2822
ATOM 2822 CGI VAL 374 58. .192 36. , 915 37. .095 1. .00 38. .68 1SG2823
ATOM 2823 CG2 VAL 374 57. .799 37. .180 34. .549 1. .00 38. .68 1SG2824
ATOM 2824 C VAL 374 55. .418 35. ,690 34. .840 1. .00 38. .68 1SG2825
ATOM 2825 O VAL 374 54. .372 36. .304 35. .024 1. ,00 38. .68 1SG2826
ATOM 2826 N GLY 375 55. .700 35. ,139 33. .648 1. .00 37. .85 1SG2827
ATOM 2827 CA GLY 375 54. .711 35. .196 32. .610 1. .00 37. .85 1SG2828
ATOM 2828 C GLY 375 55. .397 35. .719 31. .394 1. .00 37, .85 1SG2829
ATOM 2829 O GLY 375 56. .561 36. .108 31. .453 1. .00 37, .85 1SG2830
ATOM 2830 N PHE 376 54. .681 35. .751 30. .254 1. .00 39. .17 1SG2831
ATOM 2831 CA PHE 376 55. .293 36. .219 29. .045 1. .00 39. .17 1SG2832
ATOM 2832 CB PHE 376 54. .489 35. .874 27. .775 1. ,00 39. .17 1SG2833 ATOM 2833 CG PHE 376 55..231 36..413 26..599 1.,00 39.,17 1SG2834
ATOM 2834 CDl PHE 376 55. .057 37. .721 26. .200 1. .00 39. .17 1SG2835
ATOM 2835 CD2 PHE 376 56. 096 35. 615 25. ,890 1. .00 39. .17 1SG2836
ATOM 2836 CE1 PHE 376 55. .739 38. .223 25. ,118 1. .00 39. .17 1SG2837
ATOM 2837 CE2 PHE 376 56. .782 36. 111 24. .805 1. ,00 39. .17 1SG2838
ATOM 2838 CZ PHE 376 56. ,603 37. ,417 24. .417 1. ,00 39. .17 1SG2839
ATOM 2839 C PHE 376 55. ,401 37. ,706 29. .125 1. .00 39. .17 1SG2840
ATOM 2840 O PHE 376 54. .461 38. .391 29. .524 1. .00 39. .17 1SG2841
ATOM 2841 N ILE 377 56. .580 38. .239 28. .745 1. .00 39. .45 1SG2842
ATOM 2842 CA ILE 377 56. .814 39. .650 28, .766 1. .00 39. .45 1SG2843
ATOM 2843 CB ILE 377 57. .496 40. .088 30, .037 1. .00 39. .45 1SG2844
ATOM 2844 CG2 ILE 377 57. .768 41. .601 29. .988 1. .00 39. .45 1SG2845
ATOM 2845 CGI ILE 377 56. .632 39. .687 31. .244 1. .00 39. .45 1SG2846
ATOM 2846 CDl ILE 377 57. .355 39. .820 32 , .583 1. .00 39. .45 1SG2847
ATOM 2847 C ILE 377 57. .704 39. .962 27, .600 1. .00 39. .45 1SG2848
ATOM 2848 0 ILE 377 58. .328 39. .072 27, .024 1. .00 39. .45 1SG2849
ATOM 2849 N ASP 378 57. .765 41. .246 27, .197 1, .00 37, .92 1SG2850
ATOM 2850 CA ASP 378 58. .609 41. .607 26, .098 1. .00 37, .92 1SG2851
ATOM 2851 CB ASP 378 58. .495 43. .090 25 .704 1. .00 37 .92 1SG2852
ATOM 2852 CG ASP 378 57. .113 43. .311 25 .108 1 .00 37 .92 1SG2853
ATOM 2853 ODl ASP 378 56. .421 42. .296 24. .829 1. .00 37, .92 1SG2854
ATOM 2854 OD2 ASP 378 56. .732 44. .497 24, .920 1. .00 37, .92 1SG2855
ATOM 2855 C ASP 378 60. .025 41. .353 26, .516 1, .00 37, .92 1SG2856
ATOM 2856 O ASP 378 60. .509 41. .878 27, .517 1, .00 37 .92 1SG2857
ATOM 2857 N THR 379 60. .728 40. .534 25 .720 1. .00 40, .00 1SG2858
ATOM 2858 CA THR 379 62. .090 40. .143 25 .952 1. .00 40 .00 1SG2859
ATOM 2859 CB THR 379 62. .581 39, .164 24 .928 1, .00 40 .00 1SG2860
ATOM 2860 OGl THR 379 62, .631 39, .780 23 .650 1, .00 40 .00 1SG2861
ATOM 2861 CG2 THR 379 61, .613 37, .971 24 .885 1 .00 40 .00 1SG2862
ATOM 2862 C THR 379 62. .949 41. .361 25, .832 1, .00 40 .00 1SG2863
ATOM 2863 O THR 379 64. .028 41. .433 26, .415 1, .00 40 .00 1SG2864
ATOM 2864 N ASP 380 62. .487 42, .335 25 .028 1, .00 40 .50 1SG2865
ATOM 2865 CA ASP 380 63. .186 43, .545 24 .691 1, .00 40 .50 1SG2866
ATOM 2866 CB ASP 380 62, .426 44, .387 23 .654 1 .00 40 .50 1SG2867
ATOM 2867 CG ASP 380 62. .422 43, .609 22 .347 1 .00 40 .50 1SG2868
ATOM 2868 ODl ASP 380 63. .101 42, .549 22 .290 1 .00 40 .50 1SG2869
ATOM 2869 OD2 ASP 380 61. .745 44, .064 21 .387 1 .00 40 .50 1SG2870
ATOM 2870 C ASP 380 63. .411 44, .421 25 .893 1 .00 40 .50 1SG2871
ATOM 2871 O ASP 380 64. .352 45, .210 25 .908 1, .00 40 .50 1SG2872
ATOM 2872 N GLN 381 62. .550 44. .330 26 .920 1, .00 41 .97 1SG2873
ATOM 2873 CA GLN 381 62, .620 45. .201 28 .064 1, .00 41 .97 1SG2874
ATOM 2874 CB GLN 381 61, .557 44. .840 29 .108 1, .00 41 .97 1SG2875
ATOM 2875 CG GLN 381 61, .794 43, .439 29 .670 1, .00 41 .97 1SG2876
ATOM 2876 CD GLN 381 60, .714 43, .134 30 .689 1 .00 41 .97 1SG2877
ATOM 2877 OEl GLN 381 60, .638 42, .011 31 .183 1 .00 41 .97 1SG2878
ATOM 2878 NE2 GLN 381 59, .860 44, .145 31 .006 1 .00 41 .97 1SG2879
ATOM 2879 C GLN 381 63, .951 45, .085 28 .753 1 .00 41 .97 1SG2880
ATOM 2880 0 GLN 381 64. .476 46. .077 29 .258 1, .00 41, .97 1SG2881
ATOM 2881 N VAL 382 64. .508 43. .862 28 .818 1, .00 43, .64 1SG2882
ATOM 2882 CA VAL 382 65. .743 43. .530 29 .479 1, .00 43, .64 1SG2883
ATOM 2883 CB VAL 382 65, .975 42, .051 29 .608 1, .00 43, .64 1SG2884
ATOM 2884 CGI VAL 382 64, .837 41, .462 30 .459 1, .00 43 .64 1SG2885
ATOM 2885 CG2 VAL 382 66, .101 41. .437 28 .208 1 .00 43 .64 1ΞG2886
ATOM 2886 C VAL 382 66, .939 44, .099 28 .777 1 .00 43 .64 1SG2887
ATOM 2887 0 VAL 382 68, .026 44, .139 29 .351 1 .00 43 .64 1SG2888
ATOM 2888 N ARG 383 66, .799 44, .512 27 .506 1 .00 44 .42 1SG2889
ATOM 2889 CA ARG 383 67. .941 44. .908 26 .729 1, .00 44, .42 1SG2890 ATOM 2890 CB ARG 383 67.571 45..450 25.,338 1.00 44.42 1SG2891
ATOM 2891 CG ARG 383 66. .693 46. .702 25. .381 1. ,00 44. .42 1SG2892
ATOM 2892 CD ARG 383 66. ,494 47. .358 24. .012 1. ,00 44. .42 1SG2893
ATOM 2893 NE ARG 383 65. ,674 46. .434 23. .179 1. ,00 44. .42 1SG2894
ATOM 2894 CZ ARG 383 66. ,285 45. .476 22. .423 1. 00 44. .42 1SG2895
ATOM 2895 NHl ARG 383 67. .643 45, .348 22. .452 1. ,00 44. .42 1SG2896
ATOM 2896 NH2 ARG 383 65. .537 44 , .648 21. .636 1. ,00 44. .42 1SG2897
ATOM 2897 C ARG 383 68. ,734 45. .981 27. .416 1. ,00 44. .42 1SG2898
ATOM 2898 0 ARG 383 69. ,961 45. .903 27. .444 1. ,00 44. ,42 1SG2899
ATOM 2899 N THR 384 68. .082 47. .011 27, .986 1. ,00 44. .33 1SG2900
ATOM 2900 CA THR 384 68. .828 48. .078 28, .597 1. .00 44. .33 1SG2901
ATOM 2901 CB THR 384 67. .953 49. .190 29. .106 1. .00 44. .33 1SG2902
ATOM 2902 OGl THR 384 68. .753 50. .258 29. .588 1. .00 44. .33 1SG2903
ATOM 2903 CG2 THR 384 67. .038 48. .657 30, .221 1. .00 44. .33 1SG2904
ATOM 2904 C THR 384 69. .633 47. .549 29, .745 1. ,00 44. .33 1SG2905
ATOM 2905 0 THR 384 70. ,800 47. .903 29, .905 1. ,00 44. .33 1SG2906
ATOM 2906 N LEU 385 69. .029 46. .688 30, .583 1. ,00 44. .16 1SG2907
ATOM 2907 CA LEU 385 69. .727 46. .163 31, .719 1. .00 44, .16 1SG2908
ATOM 2908 CB LEU 385 68. .844 45. .276 32, .615 1. .00 44, .16 1SG2909
ATOM 2909 CG LEU 385 67. .694 46. .031 33. .307 1. .00 44, .16 1SG2910
ATOM 2910 CD2 LEU 385 67. .031 45 .162 34 .389 1. .00 44 .16 1SG2911
ATOM 2911 CDl LEU 385 66. .687 46 .580 32 .286 1. .00 44 .16 1SG2912
ATOM 2912 C LEU 385 70. .852 45. .308 31. .237 1. .00 44 .16 1SG2913
ATOM 2913 O LEU 385 71. .961 45. .355 31. .767 1. .00 44, .16 1SG2914
ATOM 2914 N MET 386 70. .577 44 .507 30 .197 1. .00 44 .90 1SG2915
ATOM 2915 CA MET 386 71. .514 43 .564 29 .667 1. .00 44 .90 1SG2916
ATOM 2916 CB MET 386 70. .915 42. .785 28. .485 1. .00 44 .90 1SG2917
ATOM 2917 CG MET 386 71. .442 41, .360 28, .311 1. .00 44, .90 1SG2918
ATOM 2918 SD MET 386 73. .233 41 .162 28 .492 1. .00 44 .90 1SG2919
ATOM 2919 CE MET 386 73. .133 40, .902 30 .285 1. .00 44 .90 1SG2920
ATOM 2920 C MET 386 72. .683 44, .330 29, .141 1. .00 44 .90 1SG2921
ATOM 2921 0 MET 386 73, .824 43, .896 29, .270 1. .00 44 .90 1SG2922
ATOM 2922 N GLY 387 72, .411 45 .491 28 .517 1. .00 43 .76 1SG2923
ATOM 2923 CA GLY 387 73, .425 46 .292 27 .897 1. .00 43 .76 1SG2924
ATOM 2924 C GLY 387 74, .405 46, .811 28, .898 1. .00 43 .76 1SG2925
ATOM 2925 0 GLY 387 75 .594 46 .875 28 .602 1, .00 43 .76 1SG2926
ATOM 2926 N THR 388 73, .940 47 .280 30 .072 1, .00 44 .82 1SG2927
ATOM 2927 CA THR 388 74, .863 47 .799 31, .042 1, .00 44 .82 1SG2928
ATOM 2928 CB THR 388 74, .198 48, .656 32, .086 1. .00 44 .82 1SG2929
ATOM 2929 OGl THR 388 75 .180 49 .257 32 .917 1, .00 44 .82 1SG2930
ATOM 2930 CG2 THR 388 73, .229 47 .804 32 .924 1. .00 44 .82 1SG2931
ATOM 2931 C THR 388 75, .629 46 .707 31, .733 1. .00 44, .82 1SG2932
ATOM 2932 0 THR 388 76, .853 46, .764 31, .841 1. .00 44, .82 1SG2933
ATOM 2933 N VAL 389 74, .918 45 .664 32 .200 1, .00 46 .33 1SG2934
ATOM 2934 CA VAL 389 75, .498 44 .625 33 .000 1. .00 46, .33 1SG2935
ATOM 2935 CB VAL 389 74, .473 43 .640 33 .466 1. .00 46, .33 1SG2936
ATOM 2936 CGI VAL 389 73, .473 44, .384 34, .364 1. .00 46, .33 1SG2937
ATOM 2937 CG2 VAL 389 73 .825 42 .997 32 .233 1. .00 46 .33 1SG2938
ATOM 2938 C VAL 389 76, .553 43 .871 32 .251 1. .00 46 .33 1SG2939
ATOM 2939 0 VAL 389 77. .617 43 .587 32, .795 1. .00 46, .33 1SG2940
ATOM 2940 N PHE 390 76 .313 43 .500 30 .983 1. .00 47, .40 1SG2941
ATOM 2941 CA PHE 390 77 .321 4 .678 30 .382 1. .00 47 .40 1SG2942
ATOM 2942 CB PHE 390 76, .940 42, .088 28, .998 1. .00 47 .40 1SG2943
ATOM 2943 CG PHE 390 77, .025 43, .102 27, .904 1. .00 47, .40 1SG2944
ATOM 2944 CDl PHE 390 78 .212 43 .281 27 .228 1. .00 47 .40 1SG2945
ATOM 2945 CD2 PHE 390 75, .943 43, .866 27, .539 1. .00 47 .40 1SG2946
ATOM 2946 CE1 PHE 390 78, .318 44, .207 26, .217 1. .00 47, .40 1SG2947 ATOM 2947 CE2 PHE 390 76.,040 44..794 26..529 1.,00 47..40 1SG2948
ATOM 2948 CZ PHE 390 77. ,229 44. ,966 25. .864 1. ,00 47. .40 1SG2949
ATOM 2949 C PHE 390 78. ,612 43. .434 30. .243 1. .00 47. ,40 1SG2950
ATOM 2950 O PHE 390 79. ,663 42. .950 30. .656 1. .00 47. ,40 1SG2951
ATOM 2951 N GLU 391 78. .571 44. .651 29. .671 1. .00 50. .18 1SG2952
ATOM 2952 CA GLU 391 79. .780 45. .378 29. .417 1. .00 50. .18 1SG2953
ATOM 2953 CB GLU 391 79. ,539 46. ,639 28. .566 1. ,00 50. .18 1SG2954
ATOM 2954 CG GLU 391 80. .817 47. .387 28. .174 1. .00 50. .18 1SG2955
ATOM 2955 CD GLU 391 81. .223 48. .294 29. .327 1. .00 50. .18 1SG2956
ATOM 2956 OEl GLU 391 80. .366 48. .535 30. .219 1. .00 50. .18 1SG2957
ATOM 2957 OE2 GLU 391 82. ,394 48. .759 29. .331 1. .00 50. .18 1SG2958
ATOM 2958 C GLU 391 80. .428 45. .807 30. .693 1. .00 50, .18 1SG2959
ATOM 2959 O GLU 391 81. .639 45. .668 30. .845 1. .00 50. .18 1SG2960
ATOM 2960 N LYS 392 79. .662 46. .397 31. .630 1. ,00 52. .33 1SG2961
ATOM 2961 CA LYS 392 80, .325 46, .859 32, .812 1. .00 52. .33 1SG2962
ATOM 2962 CB LYS 392 79, .529 47, .944 33, .571 1. .00 52. .33 1SG2963
ATOM 2963 CG LYS 392 80. .281 48. .544 34. .761 1. .00 52. .33 1SG2964
ATOM 2964 CD LYS 392 79. .637 49. .820 35. .306 1. .00 52. .33 1SG2965
ATOM 2965 CE LYS 392 79, .804 51, .033 34, .388 1. .00 52. .33 1SG2966
ATOM 2966 NZ LYS 392 79. .151 52, .217 34, .990 1. .00 52, .33 1SG2967
ATOM 2967 C LYS 392 - 80. .730 45. .727 33, .725 1. .00 52, .33 1SG2968
ATOM 2968 O LYS 392 81. .906 45. .654 34 .072 1. .00 52, .33 1SG2969
ATOM 2969 N PRO 393 79. .850 44. .863 34, .197 1. .00 51, .50 1SG2970
ATOM 2970 CA PRO 393 80. .354 43. .773 34. .999 1. .00 51, .50 1SG2971
ATOM 2971 CD PRO 393 78. .592 45. .349 34. .753 1. .00 51, .50 1SG2972
ATOM 2972 CB PRO 393 79. .263 43. .414 36 .013 1. .00 51 .50 1SG2973
ATOM 2973 CG PRO 393 78. .014 44. .162 35. .531 1, .00 51, .50 1SG2974
ATOM 2974 C PRO 393 80. .984 42, .551 34 , .379 1. .00 51, .50 1SG2975
ATOM 2975 O PRO 393 81 .982 42, .081 34 .920 1. .00 51 .50 1SG2976
ATOM 2976 N LEU 394 80. .391 41, .986 33 .302 1, .00 48 .70 1SG2977
ATOM 2977 CA LEU 394 80, .818 40, .728 32. .733 1. .00 48, .70 1SG2978
ATOM 2978 CB LEU 394 79, .700 40. .124 31, .847 1. .00 48, .70 1SG2979
ATOM 2979 CG LEU 394 79, .841 38. .652 31 .379 1, .00 48 .70 1SG2980
ATOM 2980 CD2 LEU 394 81, .148 38, .344 30, .629 1, .00 48, .70 1SG2981
ATOM 2981 CDl LEU 394 78, .620 38, .256 30, .533 1, .00 48, .70 1SG2982
ATOM 2982 C LEU 394 82 .091 40 .791 31 .929 1, .00 48 .70 1SG2983
ATOM 2983 O LEU 394 83 .012 40, .004 32, .137 1, .00 48, .70 1SG2984
ATOM 2984 N LEU 395 82, .171 41, .738 30, .982 1. .00 43, .70 1SG2985
ATOM 2985 CA LEU 395 83, .215 41. .789 29, .995 1. .00 43, .70 1SG2986
ATOM 2986 CB LEU 395 82, .949 42 .933 28 .993 1, .00 43, .70 1SG2987
ATOM 2987 CG LEU 395 83, .758 42. .912 27, .678 1. .00 43, .70 1SG2988
ATOM 2988 CD2 LEU 395 85, .267 42. .805 27. .910 1. .00 43. .70 1SG2989
ATOM 2989 CDl LEU 395 83 .384 44. .113 26 .794 1. .00 43, .70 1SG2990
ATOM 2990 C LEU 395 84 .548 41, .997 30. .649 1. .00 43, .70 1SG2991
ATOM 2991 O LEU 395 85, .545 41, .400 30. .247 1. .00 43. .70 1SG2992
ATOM 2992 N ASP 396 84, .597 42 , .845 31. .689 1. .00 36. .37 1SG2993
ATOM 2993 CA ASP 396 85 .840 43, .202 32, .309 1, .00 36, .37 1SG2994
ATOM 2994 CB ASP 396 85, .655 44, .177 33, .484 1. .00 36. .37 1SG2995
ATOM 2995 CG ASP 396 85, .200 45, .518 32, .927 1. .00 36. .37 1SG2996
ATOM 2996 ODl ASP 396 85 .191 45 .668 31, .676 1, .00 36, .37 1SG2997
ATOM 2997 OD2 ASP 396 84 .850 46, .410 33, .746 1. .00 36. .37 1SG2998
ATOM 2998 C ASP 396 86, .533 41, .991 32, .852 1. .00 36. .37 1SG2999
ATOM 2999 O ASP 396 87, .742 41, .846 32 , .683 1. .00 36. .37 1SG3000
ATOM 3000 N HIS 397 85 .795 41, .088 33, .521 1. .00 30. .90 1SG3001
ATOM 3001 CA HIS 397 86, .413 39. .945 34, .134 1. .00 30. .90 1SG3002
ATOM 3002 NDl HIS 397 83. .836 40, .637 36. .198 1. ,00 30. .90 1SG3003
ATOM 3003 CG HIS 397 84, .924 39, .793 36, .174 1. .00 30. .90 1SG3004 ATOM 3004 CB HIS 397 85..423 39..092 34.,946 1..00 30..90 1SG3005
ATOM 3005 NE2 HIS 397 84. .635 40. .572 38. .272 1. ,00 30. .90 1SG3006
ATOM 3006 CD2 HIS 397 85. .400 39. ,765 37. .449 1. .00 30. .90 1SG3007
ATOM 3007 CE1 HIS 397 83. .708 41. ,074 37. .477 1. .00 30. .90 1SG3008
ATOM 3008 C HIS 397 87. .025 39. .062 33. .093 1. .00 30. .90 1SG3009
ATOM 3009 0 HIS 397 88. .135 38. .564 33. .272 1. .00 30. .90 1SG3010
ATOM 3010 N LEU 398 86. .310 38. .842 31. .976 1. .00 28, .19 1SG3011
ATOM 3011 CA LEU 398 86. .772 37. .955 30. .948 1. .00 28, .19 1SG3012
ATOM 3012 CB LEU 398 85. .754 37. .808 29, .803 1. .00 28. .19 1SG3013
ATOM 3013 CG LEU 398 86, .214 36. .863 28, .678 1. .00 28. .19 1SG3014
ATOM 3014 CD2 LEU 398 85, .282 36. .954 27, .459 1. .00 28, .19 1SG3015
ATOM 3015 CDl LEU 398 86. .384 35. ,424 29. .191 1. .00 28. .19 1SG3016
ATOM 3016 C LEU 398 88. .049 38. ,469 30. .349 1. .00 28. .19 1SG3017
ATOM 3017 O LEU 398 88. .981 37. .702 30. .112 1. .00 28. .19 1SG3018
ATOM 3018 N ASN 399 88. .129 39. .785 30. .102 1. .00 27. .13 1SG3019
ATOM 3019 CA ASN 399 89. .285 40. .368 29. .474 1. .00 27. .13 1SG3020
ATOM 3020 CB ASN 399 89. .162 41. .879 29. .226 1. .00 27. .13 1SG3021
ATOM 3021 CG ASN 399 88, .250 42. .091 28. .029 1. .00 27, .13 1SG3022
ATOM 3022 ODl ASN 399 87, .740 41. .135 27. .447 1. .00 27, .13 1SG3023
ATOM 3023 ND2 ASN 399 88, .060 43. .378 27, .634 1. .00 27, .13 1SG3024
ATOM 3024 C ASN 399 90, .482 40. .167 30, .342 1. .00 27 .13 1SG3025
ATOM 3025 O ASN 399 91, .594 40, .037 29. .837 1. .00 27 .13 1SG3026
ATOM 3026 N ALA 400 90, .291 40, .156 31. .672 1. .00 27 .14 1SG3027
ATOM 3027 CA ALA 400 91, .407 40, .053 32 .563 1, .00 27 .14 1SG3028
ATOM 3028 CB ALA 400 90. .983 40, .052 34. .043 1. .00 27 .14 1SG3029
ATOM 3029 C ALA 400 92 .147 38, .776 32, .308 1, .00 27 .14 1SG3030
ATOM 3030 O ALA 400 93, .377 38. .769 32, .282 1. .00 27, .14 1SG3031
ATOM 3031 N LEU 401 91, .425 37. .656 32 , .124 1. .00 28, .54 1SG3032
ATOM 3032 CA LEU 401 92, .076 36. .399 31, .889 1. .00 28, .54 1SG3033
ATOM 3033 CB LEU 401 91, .091 35. .220 31, .834 1. .00 28, .54 1SG3034
ATOM 3034 CG LEU 401 91, .776 33. .862 31, .589 1, .00 28 .54 1SG3035
ATOM 3035 CD2 LEU 401 90, .741 32, .765 31, .285 1. .00 28 .54 1SG3036
ATOM 3036 CDl LEU 401 92, .719 33. .491 32, .741 1. .00 28 .54 1SG3037
ATOM 3037 C LEU 401 92, .791 36. .445 30, .575 1, .00 28 .54 1SG3038
ATOM 3038 O LEU 401 93 .934 36. .005 30, .458 1. .00 28 .54 1SG3039
ATOM 3039 N LEU 402 92, .123 36. .999 29, .550 1. .00 27 .74 1SG3040
ATOM 3040 CA LEU 402 92 .664 37. .062 28, .222 1, .00 27 .74 1SG3041
ATOM 3041 CB LEU 402 91 .700 37, .721 27. .218 1, .00 27 .74 1SG3042
ATOM 3042 CG LEU 402 90 .402 36, .927 26. .977 1, .00 27 .74 1SG3043
ATOM 3043 CD2 LEU 402 90 .700 35, .472 26 .583 1, .00 27 .74 1SG3044
ATOM 3044 CDl LEU 402 89 .494 37, .643 25 .963 1, .00 27 .74 1SG3045
ATOM 3045 C LEU 402 93, .908 37. .890 28. .252 1. .00 27, .74 1SG3046
ATOM 3046 O LEU 402 94, .891 37. .579 27. .582 1. .00 27. .74 1SG3047
ATOM 3047 N ALA 403 93, .883 38. .981 29. .036 1. .00 27, .69 1SG3048
ATOM 3048 CA ALA 403 95, .003 39. .865 29. .162 1. .00 27, .69 1SG3049
ATOM 3049 CB ALA 403 94, .711 41. .073 30. .069 1. .00 27, .69 1SG3050
ATOM 3050 C ALA 403 96, .134 39, .102 29. .775 1. .00 27, .69 1SG3051
ATOM 3051 O ALA 403 97. .294 39, .321 29. .431 1. .00 27, .69 1SG3052
ATOM 3052 N MET 404 95. .827 38, .190 30, .719 1. .00 28, .55 1SG3053
ATOM 3053 CA MET 404 96. .878 37, .443 31, .348 1. .00 28, .55 1SG3054
ATOM 3054 CB MET 404 96 .354 36, .391 32, .340 1. .00 28, .55 1SG3055
ATOM 3055 CG MET 404 95 .635 36, .980 33, .554 1. .00 28, .55 1SG3056
ATOM 3056 SD MET 404 96 .706 37, .883 34, .713 1. .00 28, .55 1SG3057
ATOM 3057 CE MET 404 96 .975 39, .313 33, .627 1. .00 28, .55 1SG3058
ATOM 3058 C MET 404 97, .569 36, .700 30, .255 1. .00 28. .55 1SG3059
ATOM 3059 O MET 404 98, .797 36, .688 30, .174 1, .00 28. .55 1SG3060
ATOM 3060 N GLY 405 96. .777 36. .079 29. .362 1. .00 30. .55 1SG3061 ATOM 3061 CA GLY 405 97..341 35,.426 28..219 1..00 30..55 1SG3062
ATOM 3062 C GLY 405 97. .667 34, .002 28. .529 1. .00 30, .55 1SG3063
ATOM 3063 O GLY 405 97, .422 33, .511 29. .630 1. .00 30, .55 1SG3064
ATOM 3064 N ILE 406 98, .229 33, .312 27. .512 1. .00 36, .43 1SG3065
ATOM 3065 CA ILE 406 98, .625 31, .938 27. .598 1. .00 36, .43 1SG3066
ATOM 3066 CB ILE 406 97, .886 31, .028 26. .660 1. .00 36. .43 1SG3067
ATOM 3067 CG2 ILE 406 98, .241 31, .437 25. .221 1. .00 36, .43 1SG3068
ATOM 3068 CGI ILE 406 98, .188 29, .557 26. .989 1. .00 36, .43 1SG3069
ATOM 3069 CDl ILE 406 97, .258 28. .570 26. .285 1. .00 36, .43 1SG3070
ATOM 3070 C ILE 406 100, .072 31, .873 27. .223 1. .00 36, .43 1SG3071
ATOM 3071 O ILE 406 100, .550 32, .655 26. .404 1. .00 36, .43 1SG3072
ATOM 3072 N ALA 407 100, .815 30, .934 27, .841 1. .00 41, .64 1SG3073
ATOM 3073 CA ALA 407 102, .225 30. .818 27. .599 1. .00 41, .64 1SG3074
ATOM 3074 CB ALA 407 102, .940 29. .885 28, .592 1. .00 41. .64 1SG3075
ATOM 3075 C ALA 407 102, .473 30. .289 26, .221 1. .00 41. .64 1SG3076
ATOM 3076 O ALA 407 101, .723 29. .459 25, .708 1. .00 41. .64 1SG3077
ATOM 3077 N LEU 408 103 , .565 30. .775 25. .593 1. .00 48, .14 1SG3078
ATOM 3078 CA LEU 408 103 , .951 30. .337 24. .280 1. .00 48, .14 1SG3079
ATOM 3079 CB LEU 408 104, .503 31. .450 23, .374 1. .00 48, .14 1SG3080
ATOM 3080 CG LEU 408 103, .418 32. .429 22 , .898 1. .00 48. .14 1SG3081
ATOM 3081 CD2 LEU 408 102, .677 33, .037 24, .094 1. .00 48. .14 1SG3082
ATOM 3082 CDl LEU 408 102 , .453 31, .760 21, .907 1. .00 48, .14 1SG3083
ATOM 3083 C LEU 408 105 .018 29 .292 24 .429 1. .00 48 .14 1SG3084
ATOM 3084 O LEU 408 105 .655 29 .138 25 .469 1. .00 48 .14 1SG3085
ATOM 3085 N PRO 409 105 .193 28 .589 23 .345 1. .00 50 .63 1SG3086
ATOM 3086 CA PRO 409 106 .089 27 .464 23 .197 1. .00 50 .63 1SG3087
ATOM 3087 CD PRO 409 104 .180 28 .611 22 .303 1, .00 50 .63 1SG3088
ATOM 3088 CB PRO 409 105 .595 26 .687 21 .975 1. .00 50 .63 1SG3089
ATOM 3089 CG PRO 409 104 .729 27, .693 21, .201 1. .00 50 .63 1SG3090
ATOM 3090 C PRO 409 107 .538 27 .839 23, .080 1, .00 50 .63 1SG3091
ATOM 3091 O PRO 409 108 .229 27, .216 22, .276 1. .00 50 .63 1SG3092
ATOM 3092 N GLY 410 108 .010 28 .903 23 .756 1. .00 48 .16 1SG3093
ATOM 3093 CA GLY 410 109 .401 29 .252 23, .613 1, .00 48 .16 1SG3094
ATOM 3094 C GLY 410 110, .270 28, .502 24. .583 1, .00 48 .16 1SG3095
ATOM 3095 O GLY 410 109, .848 28, .138 25. .678 1. .00 48, .16 1SG3096
ATOM 3096 N VAL 411 111, .549 28, .300 24. .196 1. .00 46, .19 1SG3097
ATOM 3097 CA VAL 411 112, .540 27, .644 25. .008 1. .00 46, .19 1SG3098
ATOM 3098 CB VAL 411 113, .768 27, .192 24. .265 1. .00 46, .19 1SG3099
ATOM 3099 CGI VAL 411 113, .371 26, .158 23, .202 1. .00 46, .19 1SG3100
ATOM 3100 CG2 VAL 411 114, .491 28, .427 23, .705 1. .00 46, .19 1SG3101
ATOM 3101 C VAL 411 112, .998 28, .661 26, .002 1. .00 46, .19 1SG3102
ATOM 3102 O VAL 411 112 , .587 29, .817 25. .950 1. .00 46, .19 1SG3103
ATOM 3103 N VAL 412 113, .838 28, .240 26. .965 1. .00 41. .97 1SG3104
ATOM 3104 CA VAL 412 114, .298 29. .122 27. .998 1. .00 41. .97 1SG3105
ATOM 3105 CB VAL 412 115. .013 28, .419 29, .116 1. .00 41. .97 1SG3106
ATOM 3106 CGI VAL 412 116, .296 27 .785 28 .550 1. .00 41. .97 1SG3107
ATOM 3107 CG2 VAL 412 115 .264 29, .424 30, .253 1, .00 41, .97 1SG3108
ATOM 3108 C VAL 412 115 .247 30, .139 27 .441 1. .00 41, .97 1SG3109
ATOM 3109 O VAL 412 115, .899 29 .928 26, .419 1. .00 41, .97 1SG3110
ATOM 3110 N ASN 413 115, .317 31, .294 28, .133 1. .00 39, .12 1SG3111
ATOM 3111 CA ASN 413 116. .209 32, .383 27. .849 1. .00 39, .12 1SG3112
ATOM 3112 CB ASN 413 117. .690 31, .985 27. .970 1. .00 39, .12 1SG3113
ATOM 3113 CG ASN 413 117. .965 31, .660 29. .432 1. .00 39, .12 1SG3114
ATOM 3114 ODl ASN 413 117. .585 32, .410 30. .329 1. .00 39. .12 1SG3115
ATOM 3115 ND2 ASN 413 118. .635 30, .503 29, .681 1. .00 39. .12 1SG3116
ATOM 3116 C ASN 413 115. .988 32, .964 26, .486 1. .00 39. .12 1SG3117
ATOM 3117 O ASN 413 116. .935 33, .430 25, .853 1. .00 39. .12 1SG3118 ATOM 3118 N LEU 414 114..734 32..980 25..997 1.,00 40..08 1SG3119
ATOM 3119 CA LEU 414 114. .495 33. .607 24. .728 1. ,00 40. .08 1SG3120
ATOM 3120 CB LEU 414 114, .072 32. .635 23, .602 1. .00 40. .08 1SG3121
ATOM 3121 CG LEU 414 112. .834 31. .750 23. .881 1. .00 40. .08 1SG3122
ATOM 3122 CD2 LEU 414 112. .730 30, .626 22. .839 1. .00 40. .08 1SG3123
ATOM 3123 CDl LEU 414 111. .526 32. .553 23. .980 1. .00 40. .08 1SG3124
ATOM 3124 C LEU 414 113. .402 34, .608 24. .914 1. .00 40. .08 1SG3125
ATOM 3125 O LEU 414 112. .557 34, .460 25. .795 1. .00 40. .08 1SG3126
ATOM 3126 N HIS 415 113 , .405 35 .673 24. .091 1. .00 40, .65 1SG3127
ATOM 3127 CA HIS 415 112. .363 36, .655 24, .152 1. .00 40. .65 1SG3128
ATOM 3128 NDl HIS 415 112. .223 38, .049 27, .175 1. .00 40. .65 1SG3129
ATOM 3129 CG HIS 415 113. .155 37, .987 26, .164 1. .00 40. .65 1SG3130
ATOM 3130 CB HIS 415 112. .811 38, .019 24, .705 1. ,00 40. .65 1SG3131
ATOM 3131 NE2 HIS 415 114. .214 37, .909 28. .155 1. ,00 40. .65 1SG3132
ATOM 3132 CD2 HIS 415 114, .366 37 .902 26 .779 1. .00 40, .65 1SG3133
ATOM 3133 CE1 HIS 415 112, .910 37, .999 28. .345 1. .00 40, .65 1SG3134
ATOM 3134 C HIS 415 111, .923 36, .880 22. .741 1. .00 40. .65 1SG3135
ATOM 3135 O HIS 415 112, .709 36, .722 21, .808 1. .00 40. .65 1SG3136
ATOM 3136 N TYR 416 110. .643 37, .256 22. .551 1. .00 43. .57 1SG3137
ATOM 3137 CA TYR 416 110. .137 37 .476 21 .226 1. .00 43. .57 1SG3138
ATOM 3138 CB TYR 416 108. .754 36 .840 20 .990 1. .00 43 .57 1SG3139
ATOM 3139 CG TYR 416 108, .878 35 .354 21 .035 1. .00 43, .57 1SG3140
ATOM 3140 CDl TYR 416 108. .794 34, .680 22. .233 1. .00 43, .57 1SG3141
ATOM 3141 CD2 TYR 416 109. .079 34, .633 19. .881 1. .00 43, .57 1SG3142
ATOM 3142 CE1 TYR 416 108. .907 33, .310 22, .277 1. .00 43, .57 1SG3143
ATOM 3143 CE2 TYR 416 109. .191 33 .262 19 .919 1, .00 43 .57 1SG3144
ATOM 3144 CZ TYR 416 109, .105 32 .599 21 .119 1, .00 43 .57 1SG3145
ATOM 3145 OH TYR 416 109, .222 31 .193 21, .160 1, .00 43, .57 1SG3146
ATOM 3146 C TYR 416 109, .948 38 .952 21, .062 1. .00 43, .57 1SG3147
ATOM 3147 O TYR 416 109. .383 39, .615 21, .931 1. .00 43, .57 1SG3148
ATOM 3148 N VAL 417 110. .436 39, .505 19, .931 1. .00 46, .62 1SG3149
ATOM 3149 CA VAL 417 110, .329 40 .917 19 .691 1, .00 46 .62 1SG3150
ATOM 3150 CB VAL 417 111, .637 41 .640 19 .825 1. .00 46 .62 1SG3151
ATOM 3151 CGI VAL 417 112. .131 41 .494 21, .275 1. .00 46, .62 1SG3152
ATOM 3152 CG2 VAL 417 112, .613 41. .085 18, .774 1. .00 46, .62 1SG3153
ATOM 3153 C VAL 417 109. .866 41, .122 18, .281 1. .00 46, .62 1SG3154
ATOM 3154 O VAL 417 109. .894 40 .205 17, .462 1. .00 46. .62 1SG3155
ATOM 3155 N ALA 418 109. .417 42 .359 17 .978 1. .00 47, .36 1SG3156
ATOM 3156 CA ALA 418 108, .914 42 .729 16 .682 1. .00 47, .36 1SG3157
ATOM 3157 CB ALA 418 110, .026 42 .970 15, .645 1. .00 47, .36 1SG3158
ATOM 3158 C ALA 418 107. .980 41, .681 16, .136 1. .00 47, .36 1SG3159
ATOM 3159 O ALA 418 108. .305 41, .077 15, .114 1. .00 47. .36 1SG3160
ATOM 3160 N PRO 419 106, .847 41 .401 16 .748 1. .00 48. .75 1SG3161
ATOM 3161 CA PRO 419 105. .971 40 .416 16, .171 1. .00 48. .75 1SG3162
ATOM 3162 CD PRO 419 106. .707 41 .434 18, .199 1. .00 48. .75 1SG3163
ATOM 3163 CB PRO 419 105. .251 39, .729 17, .332 1. .00 48. .75 1SG3164
ATOM 3164 CG PRO 419 105. .388 40, .712 18. .500 1. .00 48. .75 1SG3165
ATOM 3165 C PRO 419 105. .003 40, .981 15. .181 1. ,00 48. .75 1SG3166
ATOM 3166 O PRO 419 104. .754 42 .186 15, .190 1. .00 48. .75 1SG3167
ATOM 3167 N GLU 420 104, .440 40 .105 14. .326 1. .00 47. .20 1SG3168
ATOM 3168 CA GLU 420 103. .423 40, .491 13. .397 1. .00 47. .20 1SG3169
ATOM 3169 CB GLU 420 103. .925 40, .599 11. .947 1. .00 47. .20 1SG3170
ATOM 3170 CG GLU 420 102. .843 41, .014 10. .948 1. .00 47. .20 1SG3171
ATOM 3171 CD GLU 420 103. .481 41 .081 9, .567 1. .00 47. .20 1SG3172
ATOM 3172 OEl GLU 420 104. .703 40, .791 9, .466 1. .00 47. .20 1SG3173
ATOM 3173 OE2 GLU 420 102. .755 41, .420 8, .595 1. ,00 47. .20 1SG3174
ATOM 3174 C GLU 420 102. .405 39. .397 13 , .442 1. ,00 47. ,20 1SG3175 ATOM 3175 O GLU 420 102.,748 38..221 13.332 1.00 47..20 1SG3176
ATOM 3176 N ILE 421 101. ,117 39. .745 13. .627 1. ,00 46. .12 1SG3177
ATOM 3177 CA ILE 421 100. .149 38. .691 13. .647 1. ,00 46. .12 1SG3178
ATOM 3178 CB ILE 421 99. .335 38. .618 14. .913 1. ,00 46. .12 1SG3179
ATOM 3179 CG2 ILE 421 100. .300 38. .297 16. .067 1. ,00 46. .12 1SG3180
ATOM 3180 CGI ILE 421 98. .510 39. .894 15. .137 1. ,00 46. .12 1SG3181
ATOM 3181 CDl ILE 421 97, .401 39. .715 16. .170 1. .00 46. .12 1SG3182
ATOM 3182 C ILE 421 99, .234 38. .878 12. .486 1. .00 46. .12 1SG3183
ATOM 3183 O ILE 421 98. .477 39. .845 12. .405 1. .00 46. .12 1SG3184
ATOM 3184 N PHE 422 99. .287 37. .948 11. .518 1. ,00 46. .05 1SG3185
ATOM 3185 CA PHE 422 98. .371 38. .120 10. .439 1. .00 46. .05 1SG3186
ATOM 3186 CB PHE 422 99. .021 38. .530 9. .096 1. .00 46. .05 1SG3187
ATOM 3187 CG PHE 422 100. .208 37. .692 8. .770 1. .00 46. .05 1SG3188
ATOM 3188 CDl PHE 422 101, .378 37. .869 9. .473 1. .00 46, .05 1SG3189
ATOM 3189 CD2 PHE 422 100, .165 36. .743 7. .777 1. .00 46, .05 1SG3190
ATOM 3190 CE1 PHE 422 102. .491 37. .114 9. .194 1. .00 46, .05 1SG3191
ATOM 3191 CE2 PHE 422 101. .278 35. .985 7. .492 1. .00 46, .05 1SG3192
ATOM 3192 CZ PHE 422 102, .442 36. .168 8. .199 1. .00 46, .05 1SG3193
ATOM 3193 C PHE 422 97, .451 36. .949 10. .364 1. .00 46, .05 1SG3194
ATOM 3194 O PHE 422 97. .855 35. .790 10. .293 1. .00 46 .05 1SG3195
ATOM 3195 N VAL 423 96 .144 37. .254 10. .417 1, .00 43 .39 1SG3196
ATOM 3196 CA VAL 423 95 .149 36. .228 10. .454 1. .00 43 .39 1SG3197
ATOM 3197 CB VAL 423 93 .805 36. .716 10, .903 1. .00 43 .39 1SG3198
ATOM 3198 CGI VAL 423 93. .919 37. .187 12 , .363 1. .00 43, .39 1SG3199
ATOM 3199 CG2 VAL 423 93. .346 37, .818 9, .940 1. .00 43, .39 1SG3200
ATOM 3200 C VAL 423 95. .008 35, .619 9, .099 1. .00 43 .39 1SG3201
ATOM 3201 O VAL 423 95 .099 36. .296 8, .076 1, .00 43 .39 1SG3202
ATOM 3202 N TYR 424 94 .787 34, .291 9, .088 1. .00 42 .20 1SG3203
ATOM 3203 CA TYR 424 94 .601 33 .522 7, .893 1. .00 42 .20 1SG3204
ATOM 3204 CB TYR 424 95 .685 32 .474 7, .584 1. .00 42 .20 1SG3205
ATOM 3205 CG TYR 424 96, .886 33, .104 6 , .976 1. .00 42 .20 1SG3206
ATOM 3206 CDl TYR 424 96, .948 33, .259 5. .610 1. .00 42 .20 1SG3207
ATOM 3207 CD2 TYR 424 97 .943 33, .526 7, .746 1, .00 42 .20 1SG3208
ATOM 3208 CE1 TYR 424 98 .044 33, .829 5, .011 1, .00 42 .20 1SG3209
ATOM 3209 CE2 TYR 424 99 .041 34, .096 7, .150 1. .00 42 .20 1SG3210
ATOM 3210 CZ TYR 424 99 .096 34 .250 5, .785 1. .00 42 .20 1SG3211
ATOM 3211 OH TYR 424 100 .228 34 .837 5 .180 1 .00 42 .20 1SG3212
ATOM 3212 C TYR 424 93 .359 32 .725 8 .073 1. .00 42 .20 1SG3213
ATOM 3213 O TYR 424 92, .696 32, .800 9, .105 1. .00 42 .20 1SG3214
ATOM 3214 N GLU 425 92, .996 31, .945 7, .040 1. .00 40 .75 1SG3215
ATOM 3215 CA GLU 425 91 .801 31, .179 7, .179 1. .00 40 .75 1SG3216
ATOM 3216 CB GLU 425 91 .205 30. .677 5, .860 1. .00 40 .75 1SG3217
ATOM 3217 CG GLU 425 90 .621 31, .789 4, .996 1. .00 40 .75 1SG3218
ATOM 3218 CD GLU 425 89 .754 31 .104 3, .959 1, .00 40 .75 1SG3219
ATOM 3219 OEl GLU 425 88 .912 30 .265 4, .376 1, .00 40 .75 1SG3220
ATOM 3220 OE2 GLU 425 89 .920 31, .399 2, .745 1. .00 40 .75 1SG3221
ATOM 3221 C GLU. 425 92 .090 29, .977 8. .008 1. .00 40, .75 1SG3222
ATOM 3222 O GLU 425 92 .877 29, .108 7, .632 1. .00 40, .75 1SG3223
ATOM 3223 N GLY 426 91 .441 29 .918 9, .182 1, .00 39 .05 1SG3224
ATOM 3224 CA GLY 426 91 .524 28 .771 10, .033 1, .00 39 .05 1SG3225
ATOM 3225 C GLY 426 92 .688 28 .851 10, .975 1. .00 39 .05 1SG3226
ATOM 3226 O GLY 426 92 .790 28 .023 11, .880 1. .00 39 .05 1SG3227
ATOM 3227 N TYR 427 93 .621 29 .809 10 .797 1. .00 40 .10 1SG3228
ATOM 3228 CA TYR 427 94, .703 29, .840 11. .744 1. .00 40, .10 1SG3229
ATOM 3229 CB TYR 427 95, .869 28, .891 11. .407 1. .00 40, .10 1SG3230
ATOM 3230 CG TYR 427 96 .550 29. .328 10, .152 1. .00 40, .10 1SG3231
ATOM 3231 CDl TYR 427 96 .023 29. .034 8, .914 1. .00 40 .10 1SG3232 ATOM 3232 CD2 TYR 427 97..736 30..022 10..216 1..00 40..10 1SG3233
ATOM 3233 CE1 TYR 427 96. .665 29. .435 7. .765 1. ,00 40. .10 1SG3234
ATOM 3234 CE2 TYR 427 98. .382 30. .426 9. .071 1. .00 40. .10 1SG3235
ATOM 3235 CZ TYR 427 97. .846 30. .133 7. .842 1. .00 40. ,10 1SG3236
ATOM 3236 OH TYR 427 98, .504 30. .546 6. .664 1. .00 40. .10 1SG3237
ATOM 3237 C TYR 427 95. .262 31. .228 11. ,830 1. .00 40. .10 1SG3238
ATOM 3238 O TYR 427 95. .047 32. .048 10. .937 1. .00 40. .10 1SG3239
ATOM 3239 N VAL 428 96. .016 31. .503 12. .923 1. .00 40. ,45 1SG3240
ATOM 3240 CA VAL 428 96, .613 32, .789 13. .170 1. .00 40. ,45 1SG3241
ATOM 3241 CB VAL 428 96. .566 33. .206 14. .617 1. .00 40. .45 1SG3242
ATOM 3242 CGI VAL 428 97. .248 34. .578 14, .742 1. .00 40. .45 1SG3243
ATOM 3243 CG2 VAL 428 95. .132 33. .142 15. .156 1. .00 40. .45 1SG3244
ATOM 3244 C VAL 428 98, .082 32. .650 12, .899 1. .00 40. .45 1SG3245
ATOM 3245 O VAL 428 98. .708 31. .676 13. .318 1. .00 40. .45 1SG3246
ATOM 3246 N VAL 429 98. .695 33. .625 12. .198 1. .00 40. ,75 1SG3247
ATOM 3247 CA VAL 429 100. .100 33 .454 12. .003 1. .00 40. .75 1SG3248
ATOM 3248 CB VAL 429 100, .584 33. .631 10. .590 1. .00 40. .75 1SG3249
ATOM 3249 CGI VAL 429 100, .506 35 .112 10. .203 1. .00 40. .75 1SG3250
ATOM 3250 CG2 VAL 429 102, .006 33 .052 10, .498 1, .00 40. .75 1SG3251
ATOM 3251 C VAL 429 100, .809 34. .443 12. .862 1. .00 40. .75 1SG3252
ATOM 3252 O VAL 429 100 .468 35 .627 12 .891 1. .00 40. .75 1SG3253
ATOM 3253 N ILE 430 101, .810 33 .965 13. .627 1. .00 39, .24 1SG3254
ATOM 3254 CA ILE 430 102, .547 34. .911 14. .398 1. .00 39, .24 1SG3255
ATOM 3255 CB ILE 430 10 .483 34 .754 15 .897 1. .00 39, .24 1SG3256
ATOM 3256 CG2 ILE 430 103 .374 33 .587 16. .335 1. .00 39, .24 1SG3257
ATOM 3257 CGI ILE 430 102 .907 36 .072 16 .566 1, .00 39 .24 1SG3258
ATOM 3258 CDl ILE 430 102 .617 36 .117 18 .066 1, .00 39, .24 1SG3259
ATOM 3259 C ILE 430 103 .970 34 .822 13. .955 1, .00 39, .24 1SG3260
ATOM 3260 0 ILE 430 104 .556 33 .743 13 .876 1, .00 39 .24 1SG3261
ATOM 3261 N SER 431 104 .555 35 .981 13 .614 1, .00 36, .88 1SG3262
ATOM 3262 CA SER 431 105 .921 35 .989 13. .185 1, .00 36, .88 1SG3263
ATOM 3263 CB SER 431 106 .129 36 .609 11 .792 1 .00 36, .88 1SG3264
ATOM 3264 OG SER 431 105 .456 35 .838 10. .808 1, .00 36, .88 1SG3265
ATOM 3265 C SER 431 106 .653 36 .847 14 .156 1 .00 36 .88 1SG3266
ATOM 3266 O SER 431 106 .105 37 .825 14 .662 1 .00 36 .88 1SG3267
ATOM 3267 N SER 432 107 .914 36 .495 14, .469 1, .00 34, .83 1SG3268
ATOM 3268 CA SER 432 108 .616 37 .306 15 .415 1 .00 34 .83 1SG3269
ATOM 3269 CB SER 432 108 .221 36 .997 16 .871 1 .00 34, .83 1SG3270
ATOM 3270 OG SER 432 108. .940 37 .826 17 .773 1 .00 34, .83 1SG3271
ATOM 3271 C SER 432 110 .085 37 .066 15 .287 1, .00 34. .83 1SG3272
ATOM 3272 0 SER 432 110 .528 36 .142 14, .605 1, .00 34, .83 1SG3273
ATOM 3273 N GLY 433 110 .877 37 .929 15 .952 1 .00 32, .16 1SG3274
ATOM 3274 CA GLY 433 112 .302 37 .795 15 .977 1 .00 32 .16 1SG3275
ATOM 3275 C GLY 433 112, .626 37. .383 17, .375 1, .00 32. .16 1SG3276
ATOM 3276 0 GLY 433 111 .883 37 .693 18 .306 1, .00 32. .16 1SG3277
ATOM 3277 N LEU 434 113 .746 36 .662 17, .564 1, .00 32, .13 1SG3278
ATOM 3278 CA LEU 434 114 .066 36 .195 18 .879 1 .00 32, .13 1SG3279
ATOM 3279 CB LEU 434 114 .266 34 .673 18 .961 1, .00 32, .13 1SG3280
ATOM 3280 CG LEU 434 112, .969 33 .875 18, .768 1, .00 32, .13 1SG3281
ATOM 3281 CD2 LEU 434 112 .334 34 .149 17 .395 1 .00 32, .13 1SG3282
ATOM 3282 CDl LEU 434 112 .006 34 .126 19 .937 1 .00 32 .13 1SG3283
ATOM 3283 C LEU 434 115, .348 36. .805 19. .337 1, .00 32, .13 1SG3284
ATOM 3284 0 LEU 434 116 .234 37 .111 18 .544 1, .00 32, .13 1SG3285
ATOM 3285 N PHE 435 115 .450 37, .000 20, .662 1, .00 30, .83 1SG3286
ATOM 3286 CA PHE 435 116 .646 37 .495 21 .270 1 .00 30, .83 1SG3287
ATOM 3287 CB PHE 435 116 .434 38 .803 22 .049 1 .00 30 .83 1SG3288
ATOM 3288 CG PHE 435 117, .742 39, .218 22, .631 1. .00 30. .83 1SG3289 θ H CN ro -. ιn ιo r-- CD cn o H CN rθ '5. ιn ιo c^ co cn θ H CN rθ '3, ιn vo [- co n n ni oi iD Mi m o H cN co ^» in io r- oo cn o H CN ro in vo cn cn cn cn cn σi cn cn cn cn o o o o o o o o o o H H H H H H H H H H H H H H H H H CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN ro ro ro ro ro ro ro ro ro ro r ro ro ro fo ro ro r ro
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ATOM 26 C PRO 3 96..283 17,.843 13,.578 1..00 38.02 1SG 27
ATOM 27 O PRO 3 95. .693 18. .240 12. .575 1. ,00 38. .02 1SG 28
ATOM 28 N GLY 4 96. .070 18. .333 14. .811 1. .00 37. .83 1SG 29
ATOM 29 CA GLY 4 95. .179 19, .420 15. .092 1. .00 37. .83 1SG 30
ATOM 30 C GLY 4 95. .750 20, .706 14. .589 1, .00 37. .83 1SG 31
ATOM 31 O GLY 4 95. .007 21, .610 14. .210 1. .00 37, .83 1SG 32
ATOM 32 N ILE 5 97. .089 20. .858 14. .663 1. .00 40. .57 1SG 33
ATOM 33 CA ILE 5 97. .688 22. .089 14, .238 1. .00 40, .57 1SG 34
ATOM 34 CB ILE 5 98, .089 22, .972 15, .387 1. .00 40 .57 1SG 35
ATOM 35 CG2 ILE 5 99. .298 22, .328 16. .087 1. .00 40, .57 1SG 36
ATOM 36 CGI ILE 5 98. .330 24, .410 14. .899 1. .00 40, .57 1SG 37
ATOM 37 CDl ILE 5 98. .329 25. .446 16. .022 1. .00 40, .57 1SG 38
ATOM 38 C ILE 5 98. .901 21. .768 13, .427 1. .00 40, .57 1SG 39
ATOM 39 O ILE 5 99. .626 20. .819 13. .724 1. .00 40, .57 1SG 40
ATOM 40 N LYS 6 99. .136 22. .550 12. .354 1. .00 44, .99 1SG 41
ATOM 41 CA LYS 6 100. .274 22 .325 11. .514 1, .00 44 .99 1SG 42
ATOM 42 CB LYS 6 99, .886 21, .919 10, .077 1. .00 44, .99 1SG 43
ATOM 43 CG LYS 6 101. .056 21. .608 9. .132 1. .00 44 .99 1SG 44
ATOM 44 CD LYS 6 101. .936 22. .806 8. .760 1. .00 44, .99 1SG 45
ATOM 45 CE LYS 6 102, .969 22. .501 7, .675 1. .00 44 .99 1SG 46
ATOM 46 NZ LYS 6 102, .333 22 .567 6 .340 1. .00 44 .99 1SG 47
ATOM 47 C LYS 6 101. .025 23. .613 11. .433 1. .00 44 .99 1SG 48
ATOM 48 O LYS 6 100. .435 24. .686 11. .313 1. .00 44, .99 1SG 49
ATOM 49 N ALA 7 102 , .367 23. .524 11, .507 1. .00 47, .28 1SG 50
ATOM 50 CA ALA 7 103. .185 24 .692 11 .399 1. .00 47 .28 1SG 51
ATOM 51 CB ALA 7 104. .180 24. .854 12 .560 1, .00 47 .28 1SG 52
ATOM 52 C ALA 7 103. .980 24, .525 10. .151 1. .00 47, .28 1SG 53
ATOM 53 O ALA 7 104. .618 23, .497 9. .931 1. .00 47, .28 1SG 54
ATOM 54 N ARG 8 103. .956 25 .552 9, .292 1. .00 50 .29 1SG 55
ATOM 55 CA ARG 8 104, .653 25 .435 8 .056 1. .00 50 .29 1SG 56
ATOM 56 CB ARG 8 103, .678 25, .527 6. .879 1. .00 50 .29 1SG 57
ATOM 57 CG ARG 8 104. .288 25, .154 5, .543 1. .00 50, .29 1SG 58
ATOM 58 CD ARG 8 103. .293 25, .255 4, .389 1. .00 50 .29 1SG 59
ATOM 59 NE ARG 8 104, .103 25 .200 3 .147 1, .00 50 .29 1SG 60
ATOM 60 CZ ARG 8 104. .764 26, .329 2, .755 1, .00 50, .29 1SG 61
ATOM 61 NHl ARG 8 104. .598 27 .487 3 .458 1. .00 50 .29 1SG 62
ATOM 62 NH2 ARG 8 105. .611 26, .301 1, .685 1. .00 50. .29 1SG 63
ATOM 63 C ARG 8 105. .603 26, .581 7, .994 1, .00 50, .29 1SG 64
ATOM 64 O ARG 8 105. .202 27, .744 8. .006 1. .00 50, .29 1SG 65
ATOM 65 N ILE 9 106. .903 26, .271 7, .904 1. .00 48, .27 1SG 66
ATOM 66 CA ILE 9 107. .894 27 .298 7 .887 1. .00 48, .27 1SG 67
ATOM 67 CB ILE 9 109. .008 26, .957 8. .837 1. .00 48, .27 1SG 68
ATOM 68 CG2 ILE 9 109. .638 25. .661 8. .337 1. .00 48, .27 1SG 69
ATOM 69 CGI ILE 9 110. .034 28, .074 8, .990 1. .00 48. .27 1SG 70
ATOM 70 CDl ILE 9 110. .968 28, .158 7, .789 1. .00 48, .27 1SG 71
ATOM 71 C ILE 9 108. .352 27 .403 6. .467 1. .00 48, .27 1SG 72
ATOM 72 O ILE 9 108. ,752 26. .417 5, .850 1. .00 48, .27 1SG 73
ATOM 73 N THR 10 108. ,245 28. .623 5. .904 1. .00 41. .55 1SG 74
ATOM 74 CA THR 10 108. .524 28. .870 4, .519 1. .00 41. .55 1SG 75
ATOM 75 CB THR 10 107. .678 30. .007 3. .997 1. .00 41, .55 1SG 76
ATOM 76 OGl THR 10 106. .312 29 .731 4, .270 1. .00 41, .55 1SG 77
ATOM 77 CG2 THR 10 107. .847 30. .164 2. .475 1. .00 41. .55 1SG 78
ATOM 78 C THR 10 109. .977 29. .210 4. .373 1. ,00 41. ,55 1SG 79
ATOM 79 O THR 10 110. .696 29, .381 5. .356 1. .00 41. .55 1SG 80
ATOM 80 N GLN 11 110. .446 29, .322 3, .116 1. .00 36. .46 1SG 81
ATOM 81 CA GLN 11 111. ,820 29, .604 2. .840 1. .00 36. .46 1SG 82
ATOM 82 CB GLN 11 112. ,155 29. .648 1. .342 1. .00 36. .46 1SG 83 co c o H CN ro -. oo en o H ro -. ιn iD -~ co cn o H CN ro -|i ιn ιo t oo cn o o o H H H H H H H H CN CN CN CN M M iN M C M O tn m m fi ri m M n ci i. oe
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ATOM 140 CGI VAL 18 121..336 30,.762 6..971 1..00 22..89 1SG 141
ATOM 141 CG2 VAL 18 118. .923 29, .804 6. .839 1, .00 22, .89 1SG 142
ATOM 142 C VAL 18 120. .505 32, .212 9. .245 1. .00 22, .89 1SG 143
ATOM 143 O VAL 18 121. .626 32, .117 9. .740 1. .00 22, .89 1SG 144
ATOM 144 N GLN 19 119. .904 33, .397 9. .038 1, .00 24, .34 1SG 145
ATOM 145 CA GLN 19 120. .579 34. .634 9. .313 1. .00 24, .34 1SG 146
ATOM 146 CB GLN 19 119. .725 35. .860 8. ,956 1. .00 24 , .34 1SG 147
ATOM 147 CG GLN 19 120. .434 37. .191 9. .209 1. .00 24, .34 1SG 148
ATOM 148 CD GLN 19 121. .461 37, .383 8. .103 1. .00 24, .34 1SG 149
ATOM 149 OEl GLN 19 121. .149 37, .237 6. .923 1. .00 24, .34 1SG 150
ATOM 150 NE2 GLN 19 122. .723 37, .712 8. .492 1. .00 24, .34 1SG 151
ATOM 151 C GLN 19 120. .874 34, .705 10. .773 1. .00 24, .34 1SG 152
ATOM 152 O GLN 19 121. .971 35, .089 11. .173 1. .00 24, .34 1SG 153
ATOM 153 N ALA 20 119. .895 34, .333 11. .614 1. .00 24 .02 1SG 154
ATOM 154 CA ALA 20 120, .114 34, .397 13. .026 1. .00 24, .02 1SG 155
ATOM 155 CB ALA 20 118, .873 33, .994 13. .841 1. .00 24 .02 1SG 156
ATOM 156 C ALA 20 121, .205 33. .437 13 , .365 1. .00 24, .02 1SG 157
ATOM 157 0 ALA 20 122 , .110 33. .757 14. .132 1. .00 24, .02 1SG 158
ATOM 158 N GLY 21 121, .157 32 , .232 12. .772 1. .00 26. .52 1SG 159
ATOM 159 CA GLY 21 122. .115 31, .216 13. .092 1, .00 26 .52 1SG 160
ATOM 160 C GLY 21 123. .491 31, .651 12. .702 1, .00 26 .52 1SG 161
ATOM 161 0 GLY 21 124, .435 31, .497 13. .473 1, .00 26 .52 1SG 162
ATOM 162 N MET 22 123, .642 32, .226 11. .496 1, .00 32 .46 1SG 163
ATOM 163 CA MET 22 124, .939 32, .598 11, .017 1, .00 32 .46 1SG 164
ATOM 164 CB MET 22 124, .897 33, .214 9, .608 1, .00 32 .46 1SG 165
ATOM 165 CG MET 22 126, .274 33 .612 9, .075 1 .00 32 .46 1SG 166
ATOM 166 SD MET 22 126 .252 34 .340 7, .409 1 .00 32 .46 1SG 167
ATOM 167 CE MET 22 125 .413 35 .869 7, .914 1 .00 32 .46 1SG 168
ATOM 168 C MET 22 125, .520 33, .620 11. .939 1, .00 32 .46 1SG 169
ATOM 169 O MET 22 126, .695 33, .556 12. .301 1, .00 32 .46 1SG 170
ATOM 170 N LYS 23 124, .696 34, .585 12. .372 1, .00 37 .50 1SG 171
ATOM 171 CA LYS 23 125, .202 35, .609 13. .231 1, .00 37 .50 1SG 172
ATOM 172 CB LYS 23 124. .116 36, .606 13 , .668 1, .00 37 .50 1SG 173
ATOM 173 CG LYS 23 124. .637 37, .718 14, .580 1, .00 37 .50 1SG 174
ATOM 174 CD LYS 23 123. .652 38, .874 14, .759 1, .00 37 .50 1SG 175
ATOM 175 CE LYS 23 124. .169 39, .984 15, .676 1 .00 37 .50 1SG 176
ATOM 176 NZ LYS 23 123. .160 41, .061 15, .785 1 .00 37 .50 1SG 177
ATOM 177 C LYS 23 125 .716 34, .936 14, .455 1 .00 37 .50 1SG 178
ATOM 178 O LYS 23 126, .798 35 .255 14. .944 1 .00 37 .50 1SG 179
ATOM 179 N MET 24 124, .953 33 , .961 14. .971 1, .00 43. .61 1SG 180
ATOM 180 CA MET 24 125, .380 33. .254 16. .135 1, .00 43 .61 1SG 181
ATOM 181 CB MET 24 124 , .318 32 , .304 16. .721 1, .00 43. .61 1SG 182
ATOM 182 CG MET 24 123. .336 32, .980 17. .686 1, .00 43 .61 1SG 183
ATOM 183 SD MET 24 122, .192 34 , .189 16. .959 1. .00 43 .61 1SG 184
ATOM 184 CE MET 24 123, .434 35, .504 16, .792 1, .00 43 .61 1SG 185
ATOM 185 C MET 24 126, .612 32 , .455 15. .841 1, .00 43 .61 1SG 186
ATOM 186 O MET 24 127, .466 32, .328 16. .717 1, .00 43 .61 1SG 187
ATOM 187 N ILE 25 126, .753 31, .859 14. .634 1 .00 46 .79 1SG 188
ATOM 188 CA ILE 25 127, .928 31, .042 14. .513 1, .00 46 .79 1SG 189
ATOM 189 CB ILE 25 128, .090 30, .024 13, .397 1 .00 46 .79 1SG 190
ATOM 190 CG2 ILE 25 126. .766 29. .247 13. .328 1, .00 46. .79 1SG 191
ATOM 191 CGI ILE 25 128. .555 30. .570 12. .035 1. .00 46, .79 1SG 192
ATOM 192 CDl ILE 25 127. .507 31. .213 11. .156 1, .00 46, .79 1SG 193
ATOM 193 C ILE 25 129. .145 31. .903 14. .465 1. .00 46, .79 1SG 194
ATOM 194 O ILE 25 130. .202 31. .497 14. .940 1. .00 46, .79 1SG 195
ATOM 195 N GLU 26 129. .042 33. .113 13. .879 1. .00 44, .83 1SG 196
ATOM 196 CA GLU 26 130. .214 33. .915 13. .668 1. .00 44. .83 1SG 197 ATOM 197 CB GLU 26 129..929 35..299 13..052 1.,00 44.,83 1SG 198
ATOM 198 CG GLU 26 129. .159 36. .251 13. ,966 1. ,00 44. .83 1SG 199
ATOM 199 CD GLU 26 128. .971 37. .567 13. .224 1. .00 44. ,83 1SG 200
ATOM 200 OEl GLU 26 129. .446 37. ,664 12. .061 1. ,00 44. .83 1SG 201
ATOM 201 OE2 GLU 26 128. .352 38. .493 13. .812 1. .00 44. .83 1SG 202
ATOM 202 C GLU 26 130. .932 34. ,141 14. .964 1. .00 44. ,83 1SG 203
ATOM 203 O GLU 26 132. ,160 34. ,087 15. .001 1. ,00 44. ,83 1SG 204
ATOM 204 N GLN 27 130. .205 34. ,375 16. .072 1. ,00 43. ,67 1SG 205
ATOM 205 CA GLN 27 130. .888 34. ,642 17. .307 1. .00 43. ,67 1SG 206
ATOM 206 CB GLN 27 129, .945 34. .909 18. .495 1. ,00 43. ,67 1SG 207
ATOM 207 CG GLN 27 129. .140 36. .204 18. .375 1. ,00 43. ,67 1SG 208
ATOM 208 CD GLN 27 127. .944 35. .934 17. .476 1. 00 43. ,67 1SG 209
ATOM 209 OEl GLN 27 127. .509 34. .792 17. ,336 1. ,00 43. .67 1SG 210
ATOM 210 NE2 GLN 27 127. .393 37. .012 16. .855 1. ,00 43. ,67 1SG 211
ATOM 211 C GLN 27 131. .727 33. .457 17. ,672 1. .00 43. ,67 1SG 212
ATOM 212 O GLN 27 132. .871 33. .609 18. .097 1. .00 43. .67 1SG 213
ATOM 213 N MET 28 131. .185 32. .238 17. .507 1. .00 42. .82 1SG 214
ATOM 214 CA MET 28 131. .906 31. .053 17. .874 1. ,00 42. .82 1SG 215
ATOM 215 CB MET 28 131. .077 29. .767 17. .732 1. ,00 42. .82 1SG 216
ATOM 216 CG MET 28 131. .759 28, .550 18. .358 1. ,00 42. .82 1SG 217
ATOM 217 SD MET 28 131. .823 28. .571 20. .175 1. ,00 42. .82 1SG 218
ATOM 218 CE MET 28 132. .688 26. .980 20, .322 1. .00 42. .82 1SG 219
ATOM 219 C MET 28 133 .118 30, .917 17, .002 1. .00 42, .82 1SG 220
ATOM 220 o MET 28 134. .176 30. .495 17, .465 1. .00 42, .82 1SG 221
ATOM 221 N LEU 29 13 .993 31, .265 15. .707 1. .00 44, .27 1SG 222
ATOM 222 CA LEU 29 134. .092 31. .145 14, .788 1. .00 44, .27 1SG 223
ATOM 223 CB LEU 29 133 .727 31. .494 13, .333 1. .00 44, .27 1SG 224
ATOM 224 CG LEU 29 132 .994 30. .373 12 .573 1, .00 44, .27 1SG 225
ATOM 225 CD2 LEU 29 131 .725 29. .913 13, .301 1. .00 44, .27 1SG 226
ATOM 226 CDl LEU 29 133 .948 29, .208 12 .269 1. .00 44, .27 1SG 227
ATOM 227 C LEU 29 135 .210 32, .054 15. .195 1. .00 44, .27 1SG 228
ATOM 228 0 LEU 29 136 .378 31, .690 15. .088 1. .00 44 .27 1SG 229
ATOM 229 N LYS 30 134 .879 33, .257 15. .689 1. .00 47, .13 1SG 230
ATOM 230 CA LYS 30 135 .857 34. .249 16. .049 1, .00 47 .13 1SG 231
ATOM 231 CB LYS 30 135 .203 35. .507 16. .645 1. . 00 47, .13 1SG 232
ATOM 232 CG LYS 30 136 .098 36. .746 16. .669 1. .00 47 .13 1SG 233
ATOM 233 CD LYS 30 136 .160 37. .471 15. .325 1. .00 47, .13 1SG 234
ATOM 234 CE LYS 30 134 .889 38. .277 15. .039 1, .00 47, .13 1SG 235
ATOM 235 NZ LYS 30 134. .993 38. .961 13, .733 1. .00 47. .13 1SG 236
ATOM 236 C LYS 30 136 .735 33 , .685 17, .125 1. .00 47. .13 1SG 237
ATOM 237 O LYS 30 137. .914 34, .018 17, .224 1. .00 47. .13 1SG 238
ATOM 238 N GLU 31 136 .148 32, .826 17. .972 1. .00 49, .94 1SG 239
ATOM 239 CA GLU 31 136 .743 32, .235 19. .136 1. .00 49. .94 1SG 240
ATOM 240 CB GLU 31 135 .720 31. .472 19. .996 1. .00 49. .94 1SG 241
ATOM 241 CG GLU 31 134 .668 32. .376 20 .641 1, .00 49. .94 1SG 242
ATOM 242 CD GLU 31 133 .728 31 .495 21 .451 1. .00 49 .94 1SG 243
ATOM 243 OEl GLU 31 133 .948 30. .254 21 .466 1, .00 49. .94 1SG 244
ATOM 244 OE2 GLU 31 132 .780 32 .050 22 .068 1. .00 49 .94 1SG 245
ATOM 245 C GLU 31 137 .849 31. .268 18 .824 1. .00 49 .94 1SG 246
ATOM 246 O GLU 31 138 .676 31 .015 19 .695 1. .00 49, .94 1SG 247
ATOM 247 N LYS 32 137 .904 30, .657 17 .622 1. .00 53 .38 1SG 248
ATOM 248 CA LYS 32 138 .866 29 .595 17 .485 1, .00 53, .38 1SG 249
ATOM 249 CB LYS 32 138 .785 28, .724 16, .207 1, .00 53 .38 1SG 250
ATOM 250 CG LYS 32 139 .414 29 .268 14 .921 1. .00 53, .38 1SG 251
ATOM 251 CD LYS 32 138 .649 30, .406 14, .256 1. .00 53 .38 1SG 252
ATOM 252 CE LYS 32 139 .260 30 .859 12 .929 1. .00 53 .38 1SG 253
ATOM 253 NZ LYS 32 140 .633 31, .368 13, .146 1. .00 53 .38 1SG 254 ATOM 254 C LYS 32 140..270 30.,067 17..671 1..00 53..38 1SG 255
ATOM 255 O LYS 32 140. .641 31. ,189 17. .326 1. .00 53. .38 1SG 256
ATOM 256 N LYS 33 141. .093 29. .186 18. .274 1. .00 53. ,56 1SG 257
ATOM 257 CA LYS 33 142. .453 29. .532 18. .540 1. .00 53. ,56 1SG 258
ATOM 258 CB LYS 33 142. .894 29. .240 19. .985 1. .00 53. ,56 1SG 259
ATOM 259 CG LYS 33 142, .261 30. .169 21, .023 1. .00 53. .56 1SG 260
ATOM 260 CD LYS 33 142, .648 31, .639 20, .845 1. .00 53. .56 1SG 261
ATOM 261 CE LYS 33 142, .016 32 , .569 21, .882 1. .00 53. .56 1SG 262
ATOM 262 NZ LYS 33 142, .659 32, .370 23, .200 1. .00 53. .56 1SG 263
ATOM 263 C LYS 33 143, .328 28, .723 17, .646 1. .00 53. .56 1SG 264
ATOM 264 O LYS 33 143, .192 27, .503 17, .556 1. .00 53. .56 1SG 265
ATOM 265 N LEU 34 144. .253 29. .400 16. .941 1. .00 53. ,73 1SG 266
ATOM 266 CA LEU 34 145. .170 28. .670 16. .126 1. .00 53. ,73 1SG 267
ATOM 267 CB LEU 34 145, .251 29. .154 14. .659 1. .00 53. .73 1SG 268
ATOM 268 CG LEU 34 145, .921 30. .516 14 , .412 1. .00 53. ,73 1SG 269
ATOM 269 CD2 LEU 34 145, .488 31. .114 13 , .064 1. .00 53. .73 1SG 270
ATOM 270 CDl LEU 34 147, .445 30, .422 14. .555 1, .00 53. .73 1SG 271
ATOM 271 C LEU 34 146, .493 28, .753 16, .821 1. .00 53. .73 1SG 272
ATOM 272 O LEU 34 146, .827 29, .749 17, .462 1, .00 53. .73 1SG 273
ATOM 273 N PRO 35 147, .231 27, .686 16. .725 1. .00 51. .12 1SG 274
ATOM 274 CA PRO 35 148 .482 27, .555 17 .426 1. .00 51. .12 1SG 275
ATOM 275 CD PRO 35 146 .627 26, .394 16 .453 1. .00 51, .12 1SG 276
ATOM 276 CB PRO 35 148 .810 26, .058 17 .432 1. .00 51, .12 1SG 277
ATOM 277 CG PRO 35 147 .819 25 .429 16 .436 1. .00 51, .12 1SG 278
ATOM 278 C PRO 35 149 .574 28 .405 16 .869 1, .00 51, .12 1SG 279
ATOM 279 O PRO 35 149 .414 28 .992 15 .803 1 .00 51, .12 1SG 280
ATOM 280 N ASP 36 150, .684 28, .529 17, .613 1, .00 45. .05 1SG 281
ATOM 281 CA ASP 36 151, .790 29, .302 17, .140 1, .00 45. .05 1SG 282
ATOM 282 CB ASP 36 152, .536 30, .046 18, .258 1. .00 45. .05 1SG 283
ATOM 283 CG ASP 36 153 .070 29, .017 19, .240 1, .00 45. .05 1SG 284
ATOM 284 ODl ASP 36 152 .283 28, .120 19, .645 1, .00 45, .05 1SG 285
ATOM 285 OD2 ASP 36 154 .275 29 .109 19 .594 1, .00 45, .05 1SG 286
ATOM 286 C ASP 36 152 .743 28, .371 16 .468 1, .00 45, .05 1SG 287
ATOM 287 O ASP 36 152 .949 27 .246 16 .924 1, .00 45, .05 1SG 288
ATOM 288 N LEU 37 153 .330 28 .799 15 .332 1, .00 39, .78 1SG 289
ATOM 289 CA LEU 37 154 .251 27 .906 14 .696 1, .00 39, .78 1SG 290
ATOM 290 CB LEU 37 153 .935 27 .550 13 .230 1. .00 39, .78 1SG 291
ATOM 291 CG LEU 37 152 .695 26 .638 13 .118 1, .00 39, .78 1SG 292
ATOM 292 CD2 LEU 37 152 .673 25 .599 14 .251 1, .00 39, .78 1SG 293
ATOM 293 CDl LEU 37 152 .572 25 .995 11 .727 1, .00 39, .78 1SG 294
ATOM 294 C LEU 37 155 .636 28 .442 14 .785 1 .00 39, .78 1SG 295
ATOM 295 O LEU 37 155 .927 29, .572 14, .390 1, .00 39. .78 1SG 296
ATOM 296 N SER 38 156 .532 27, .602 15, .333 1. .00 34. .91 1SG 297
ATOM 297 CA SER 38 157 .903 27, .966 15, .480 1. .00 34. .91 1SG 298
ATOM 298 CB SER 38 158 .333 28, .061 16 .951 1, .00 34. .91 1SG 299
ATOM 299 OG SER 38 157 .581 29, .068 17, .613 1, .00 34. .91 1SG 300
ATOM 300 C SER 38 158 .699 26 .876 14 .839 1. .00 34. .91 1SG 301
ATOM 301 O SER 38 158 .338 25, .702 14 .916 1, .00 34. .91 1SG 302
ATOM 302 N GLY 39 159 .807 27, .247 14 .169 1, .00 32, .75 1SG 303
ATOM 303 CA GLY 39 160 .628 26, .265 13 .526 1, .00 32. .75 1SG 304
ATOM 304 C GLY 39 161 .909 26 .943 13 .161 1, .00 32, .75 1SG 305
ATOM 305 O GLY 39 161 .996 28 .168 13 .175 1, .00 32, .75 1SG 306
ATOM 306 N SER 40 162 .954 26 .150 12 .851 1, .00 33, .97 1SG 307
ATOM 307 CA SER 40 164 .217 26 .706 12 .456 1, .00 33, .97 1SG 308
ATOM 308 CB SER 40 165 .430 25 .862 12 .883 1, .00 33, .97 1SG 309
ATOM 309 OG SER 40 165 .533 25 .834 14 .298 1, .00 33, .97 1SG 310
ATOM 310 C SER 40 164, .233 26, .766 10, .966 1. .00 33. .97 1SG 311 ATOM 311 O SER 40 163..317 26,.276 10.308 1..00 33.97 1SG 312
ATOM 312 N GLU 41 165, .270 27, .404 10 .388 1. .00 34, .78 1SG 313
ATOM 313 CA GLU 41 165 .350 27 .447 8 .959 1. .00 34 .78 1SG 314
ATOM 314 CB GLU 41 164, .546 28 .597 8 .329 1, .00 34 .78 1SG 315
ATOM 315 CG GLU 41 164. .632 28, .640 6 .802 1. .00 34, .78 1SG 316
ATOM 316 CD GLU 41 163 .796 29 .817 6 .318 1. .00 34 .78 1SG 317
ATOM 317 OEl GLU 41 163 .194 30 .508 7 .182 1, .00 34 .78 1SG 318
ATOM 318 OE2 GLU 41 163. .749 30, .039 5 .079 1. .00 34. .78 1SG 319
ATOM 319 C GLU 41 166 .775 27 .642 8 .580 1. .00 34 .78 1SG 320
ATOM 320 O GLU 41 167. .582 28, .103 9 .384 1. .00 34 .78 1SG 321
ATOM 321 N SER 42 167. .122 27, .238 7 .341 1. .00 34. .16 1SG 322
ATOM 322 CA SER 42 168 .440 27, .459 6 .833 1, .00 34 .16 1SG 323
ATOM 323 CB SER 42 169. .348 26, .221 6 .916 1. .00 34. .16 1SG 324
ATOM 324 OG SER 42 168. .836 25. .184 6, .092 1. .00 34, .16 1SG 325
ATOM 325 C SER 42 168. .283 27. .797 5 .385 1, .00 34 .16 1SG 326
ATOM 326 O SER 42 167. .724 27. .024 4 .610 1. .00 34 .16 1SG 327
ATOM 327 N LEU 43 168, .772 28. .984 4, .987 1. .00 33, .59 1SG 328
ATOM 328 CA LEU 43 168 .710 29. .384 3 .614 1, .00 33 .59 1SG 329
ATOM 329 CB LEU 43 168, .004 30, .745 3 .432 1, .00 33 .59 1SG 330
ATOM 330 CG LEU 43 167, .693 31. .163 1, .979 1. .00 33, .59 1SG 331
ATOM 331 CD2 LEU 43 168, .932 31. .128 1 .078 1. .00 33 .59 1SG 332
ATOM 332 CDl LEU 43 166, .992 32, .530 1 .944 1, .00 33 .59 1SG 333
ATOM 333 C LEU 43 170, .147 29. .517 3, .232 1. .00 33, .59 1SG 334
ATOM 334 O LEU 43 170, .940 30. .068 3 .994 1. .00 33 .59 1SG 335
ATOM 335 N GLU 44 170, .535 29, .017 2 .043 1, .00 33 .18 1SG 336
ATOM 336 CA GLU 44 171, .927 29, .009 1, .703 1. .00 33 , .18 1SG 337
ATOM 337 CB GLU 44 172, .179 28, .459 0 .289 1. .00 33 .18 1SG 338
ATOM 338 CG GLU 44 171, .828 26, .977 0 .144 1. .00 33, .18 1SG 339
ATOM 339 CD GLU 44 172. .099 26, .565 -1, .296 1. .00 33 , .18 1SG 340
ATOM 340 OEl GLU 44 172. .532 27. .442 -2 .091 1. .00 33 .18 1SG 341
ATOM 341 OE2 GLU 44 171. .873 25, .369 -1 .621 1. .00 33, .18 1SG 342
ATOM 342 C GLU 44 172 , .451 30, .408 1, .742 1. .00 33, .18 1SG 343
ATOM 343 O GLU 44 173. .486 30 .672 2 .353 1. .00 33 .18 1SG 344
ATOM 344 N PHE 45 171, .748 31. .347 1 .089 1. .00 35, .19 1SG 345
ATOM 345 CA PHE 45 172. .192 32. .708 1, .083 1. .00 35, .19 1SG 346
ATOM 346 CB PHE 45 171, .421 33. .573 0 .072 1. .00 35 .19 1SG 347
ATOM 347 CG PHE 45 171, .752 33. .070 -1 .291 1. .00 35, .19 1SG 348
ATOM 348 CDl PHE 45 171. .089 31. .983 -1, .813 1. ,00 35. .19 1SG 349
ATOM 349 CD2 PHE 45 172, .724 33, .684 -2 .048 1. .00 35. .19 1SG 350
ATOM 350 CE1 PHE 45 171. .391 31. .515 -3, .070 1. .00 35, .19 1SG 351
ATOM 351 CE2 PHE 45 173. .029 33. .220 -3, .305 1. ,00 35. .19 1SG 352
ATOM 352 CZ PHE 45 172. .363 32. .133 -3 .818 1. .00 35. .19 1SG 353
ATOM 353 C PHE 45 172. .018 33. .344 2, .432 1. .00 35. .19 1SG 354
ATOM 354 O PHE 45 172. .942 33. .970 2 , .950 1. .00 35. .19 1SG 355
ATOM 355 N LEU 46 170. .818 33. .196 3 .034 1. .00 40. .46 1SG 356
ATOM 356 CA LEU 46 170. .505 33. .921 4, .235 1. .00 40. .46 1SG 357
ATOM 357 CB LEU 46 169. .026 33. ,783 4 , .637 1. ,00 40. .46 1SG 358
ATOM 358 CG LEU 46 168. .659 34. .552 5, .920 1. .00 40. .46 1SG 359
ATOM 359 CD2 LEU 46 167. .243 34. .194 6, .399 1. .00 40. .46 1SG 360
ATOM 360 CDl LEU 46 168. ,858 36. .065 5. .737 1. 00 40. ,46 1SG 361
ATOM 361 C LEU 46 171. .333 33. .501 5, .411 1. ,00 40. .46 1SG 362
ATOM 362 O LEU 46 172. ,011 34. .348 5. .990 1. ,00 40. ,46 1SG 363
ATOM 363 N LYS 47 171. ,305 32. .191 5. .764 1. 00 47. ,89 1SG 364
ATOM 364 CA LYS 47 172. .003 31. ,586 6. .878 1. ,00 47. ,89 1SG 365
ATOM 365 CB LYS 47 172. .596 32. ,549 7. .932 1. 00 47. ,89 1SG 366
ATOM 366 CG LYS 47 173. .641 31. 916 8. .856 1. 00 47. 89 1SG 367
ATOM 367 CD LYS 47 174. ,940 31. .533 8. .144 1. 00 47. ,89 1SG 368 ATOM 368 CE LYS 47 175..834 32..730 7..814 1..00 47..89 1SG 369
ATOM 369 NZ LYS 47 176. .456 33. .254 9. ,050 1, .00 47. .89 1SG 370
ATOM 370 C LYS 47 171. .001 30, .735 7. ,598 1. .00 47. .89 1SG 371
ATOM 371 O LYS 47 169. .925 30, .449 7. .074 1. .00 47. .89 1SG 372
ATOM 372 N VAL 48 171. .343 30. .283 8. .822 1. .00 53 .25 1SG 373
ATOM 373 CA VAL 48 170, .415 29. .512 9. .593 1. .00 53. .25 1SG 374
ATOM 374 CB VAL 48 171, .063 28. .449 10. .434 1. .00 53. .25 1SG 375
ATOM 375 CGI VAL 48 171, .725 27, .426 9. .496 1. .00 53 .25 1SG 376
ATOM 376 CG2 VAL 48 172, .046 29, .116 11. .410 1. .00 53 .25 1SG 377
ATOM 377 C VAL 48 169, .733 30, .476 10. .506 1. .00 53. .25 1SG 378
ATOM 378 O VAL 48 170, .379 31. .283 11. .173 1. .00 53 .25 1SG 379
ATOM 379 N ASP 49 168. .387 30. .437 10. .533 1. .00 58. .24 1SG 380
ATOM 380 CA ASP 49 167. .686 31. .382 11. .345 1. .00 58. .24 1SG 381
ATOM 381 CB ASP 49 167. .008 32. .506 10. ,540 1. .00 58. .24 1SG 382
ATOM 382 CG ASP 49 165. .957 31, .878 9. .636 1. .00 58. .24 1SG 383
ATOM 383 ODl ASP 49 166, .009 30, .634 9. .445 1. .00 58. .24 1SG 384
ATOM 384 OD2 ASP 49 165. .089 32, .635 9. .125 1. .00 58 .24 1SG 385
ATOM 385 C ASP 49 166, .621 30. .686 12. .121 1. .00 58. .24 1SG 386
ATOM 386 O ASP 49 166, .235 29, .560 11. .806 1. .00 58 .24 1SG 387
ATOM 387 N TYR 50 166, .142 31, .369 13. .185 1. .00 66 .35 1SG 388
ATOM 388 CA TYR 50 165, .154 30 .824 14, .060 1. .00 66 .35 1SG 389
ATOM 389 CB TYR 50 165, .672 29, .426 14 , .479 1. .00 66 .35 1SG 390
ATOM 390 CG TYR 50 164. .940 28 .631 15, .510 1. .00 66 .35 1SG 391
ATOM 391 CDl TYR 50 163 .837 27 .872 15, .190 1, .00 66 .35 1SG 392
ATOM 392 CD2 TYR 50 165 .411 28 .597 16 .802 1. .00 66 .35 1SG 393
ATOM 393 CE1 TYR 50 163. .204 27 .116 16, .152 1. .00 66 .35 1SG 394
ATOM 394 CE2 TYR 50 164. .784 27. .845 17. .768 1. ,00 66. .35 1SG 395
ATOM 395 CZ TYR 50 163 , .676 27. .099 17. .444 1. .00 66. .35 1SG 396
ATOM 396 OH TYR 50 163. .033 26. .325 18. .434 1. .00 66, .35 1SG 397
ATOM 397 C TYR 50 165. .138 31, .726 15. .273 1. .00 66 .35 1SG 398
ATOM 398 O TYR 50 166. .101 31, .751 16. .023 1. .00 66, .35 1SG 399
ATOM 399 N VAL 51 164. .100 32 .550 15". .538 1. .00 69, .60 1SG 400
ATOM 400 CA VAL 51 164. .070 32 .994 16. .916 1. .00 69 .60 1SG 401
ATOM 401 CB VAL 51 163. .467 34, .344 17, .232 1. .00 69 .60 1SG 402
ATOM 402 CGI VAL 51 163. .396 34 .495 18, .765 1. .00 69 .60 1SG 403
ATOM 403 CG2 VAL 51 164. .325 35 .457 16, .641 1. .00 69 .60 1SG 404
ATOM 404 C VAL 51 163. .058 32 .025 17 .366 1. .00 69 .60 1SG 405
ATOM 405 O VAL 51 161, .966 32 .376 17 .817 1. .00 69 .60 1SG 406
ATOM 406 N ASN 52 163, .451 30 .747 17, .262 1. .00 74 .77 1SG 407
ATOM 407 CA ASN 52 162, .450 29 .758 17 .261 1. .00 74 .77 1SG 408
ATOM 408 CB ASN 52 161 .659 29 .692 18 .578 1. .00 74 .77 1SG 409
ATOM 409 CG ASN 52 160. .857 28 .400 18, .574 1. .00 74, .77 1SG 410
ATOM 410 ODl ASN 52 160. .946 27, .611 17. .635 1. ,00 74. .77 1SG 411
ATOM 411 ND2 ASN 52 160. .054 28, .176 19. .648 1. .00 74 , .77 1SG 412
ATOM 412 C ASN 52 161, .546 30 .250 16, .175 1. .00 74. .77 1SG 413
ATOM 413 O ASN 52 160, .338 30 .180 16, .407 1. .00 74. .77 1SG 414
ATOM 414 N TYR 53 162. .153 30, .748 15. .025 1. .00 77. .76 1SG 415
ATOM 415 CA TYR 53 161. .564 31 .429 13, .868 1. .00 77. .76 1SG 416
ATOM 416 CB TYR 53 162. .068 30 .826 12, .534 1. .00 77. .76 1SG 417
ATOM 417 CG TYR 53 161 .085 30 .979 11, .417 1. .00 77. .76 1SG 418
ATOM 418 CDl TYR 53 160, .060 30, .067 11, .292 1. .00 77. .76 1SG 419
ATOM 419 CD2 TYR 53 161, .185 31 .976 10, .476 1. .00 77. .76 1SG 420
ATOM 420 CE1 TYR 53 159, .131 30 .144 10, .286 1. .00 77. .76 1SG 421
ATOM 421 CE2 TYR 53 160 .257 32 .060 9, .461 1. .00 77. .76 1SG 422
ATOM 422 CZ TYR 53 159, .229 31 .151 9 .363 1. .00 77, .76 1SG 423
ATOM 423 OH TYR 53 158, .279 31 .240 8. .323 1. .00 77, .76 1SG 424
ATOM 424 C TYR 53 160. .107 31, .272 13. .985 1. .00 77. .76 1SG 425 ATOM 425 O TYR 53 159..620 30.148 13..983 1..00 77,.76 1SG 426
ATOM 426 N ASN 54 159, .345 32 .367 14 .152 1. .00 69 .25 1SG 427
ATOM 427 CA ASN 54 158, .021 31 .969 14. .492 1. .00 69, .25 1SG 428
ATOM 428 CB ASN 54 157, .870 31 .590 15 .975 1, .00 69 .25 1SG 429
ATOM 429 CG ASN 54 158, .150 32 .833 16 .808 1. .00 69 .25 1SG 430
ATOM 430 ODl ASN 54 159. .133 33, .538 16, .585 1. .00 69, .25 1SG 431
ATOM 431 ND2 ASN 54 157. .257 33 .116 17, .794 1. .00 69, .25 1SG 432
ATOM 432 C ASN 54 156. .993 32 .999 14 .215 1, .00 69 .25 1SG 433
ATOM 433 O ASN 54 157. .260 34 .195 14 .099 1. .00 69 .25 1SG 434
ATOM 434 N PHE 55 155. .757 32, .487 14, .091 1. .00 62, .75 1SG 435
ATOM 435 CA PHE 55 154. .572 33, .268 13, .958 1. .00 62, .75 1SG 436
ATOM 436 CB PHE 55 153. .773 32 .961 12 .680 1, .00 62 .75 1SG 437
ATOM 437 CG PHE 55 154 .553 33 .493 11 .527 1. .00 62 .75 1SG 438
ATOM 438 CDl PHE 55 155. .677 32, .842 11, .077 1. ,00 62, .75 1SG 439
ATOM 439 CD2 PHE 55 154. .155 34, .643 10, .887 1. .00 62 .75 1SG 440
ATOM 440 CE1 PHE 55 156. .394 33 .333 10 .012 1. .00 62 .75 1SG 441
ATOM 441 CE2 PHE 55 154 .867 35 .138 9 .821 1. .00 62 .75 1SG 442
ATOM 442 CZ PHE 55 155. .991 34, .484 9, .381 1. .00 62, .75 1SG 443
ATOM 443 C PHE 55 153. .737 32, .859 15, .127 1. .00 62, .75 1SG 444
ATOM 444 0 PHE 55 153. .500 31 .669 15 .334 1. .00 62 .75 1SG 445
ATOM 445 N SER 56 153. .276 33 .834 15, .937 1. .00 52 .76 1SG 446
ATOM 446 CA SER 56 152. .534 33, .460 17, .105 1. .00 52 .76 1SG 447
ATOM 447 CB SER 56 153. .433 33 .166 18, .319 1. .00 52, .76 1SG 448
ATOM 448 OG SER 56 154. .358 32 .134 18 .008 1. .00 52 .76 1SG 449
ATOM 449 C SER 56 151. .648 34, .602 17, .498 1. .00 52, .76 1SG 450
ATOM 450 O SER 56 151, .585 35, .625 16. .817 1. .00 52 .76 1SG 451
ATOM 451 N ASN 57 150. .932 34, .428 18. .630 1. .00 44, .30 1SG 452
ATOM 452 CA ASN 57 150. .058 35 .431 19, .171 1, .00 44 .30 1SG 453
ATOM 453 CB ASN 57 150. .803 36, .699 19, .625 1. .00 44, .30 1SG 454
ATOM 454 CG ASN 57 151. .669 36 .331 20, .821 1. .00 44 .30 1SG 455
ATOM 455 ODl ASN 57 152. .890 36, .482 20, .790 1. .00 44, .30 1SG 456
ATOM 456 ND2 ASN 57 151, .022 35 .833 21, .909 1. .00 44 .30 1SG 457
ATOM 457 C ASN 57 149, .057 35, .823 18. .136 1. .00 44, .30 1SG 458
ATOM 458 O ASN 57 148. .756 37 .002 17. .961 1, .00 44 .30 1SG 459
ATOM 459 N ILE 58 148. .489 34, .816 17. .450 1. .00 41, .68 1SG 460
ATOM 460 CA ILE 58 147. .538 35, .017 16. .398 1. .00 41, .68 1SG 461
ATOM 461 CB ILE 58 147. .372 33, .775 15. .554 1. .00 41, .68 1SG 462
ATOM 462 CG2 ILE 58 148. .776 33 .334 15. .103 1. .00 41 .68 1SG 463
ATOM 463 CGI ILE 58 146. .660 32, .639 16. .322 1. .00 41, .68 1ΞG 464
ATOM 464 CDl ILE 58 145. .128 32, .664 16. .271 1. ,00 41, .68 1SG 465
ATOM 465 C ILE 58 146. .210 35, .283 17. .037 1. .00 41, .68 1SG 466
ATOM 466 0 ILE 58 145. .845 34, .640 18. .020 1. .00 41, .68 1SG 467
ATOM 467 N LYS 59 145, .464 36, .272 16. .510 1. .00 37, .15 1SG 468
ATOM 468 CA LYS 59 144. .148 36. .534 17. .018 1. .00 37, .15 1SG 469
ATOM 469 CB LYS 59 144. .051 37. .828 17. .844 1. .00 37, .15 1SG 470
ATOM 470 CG LYS 59 144. .837 37. .776 19, .156 1. .00 37. .15 1SG 471
ATOM 471 CD LYS 59 145. .009 39. .143 19. .821 1. .00 37. .15 1SG 472
ATOM 472 CE LYS 59 143. .723 39. .686 20. .448 1. .00 37. .15 1SG 473
ATOM 473 NZ LYS 59 143. .980 41. .004 21. .069 1. .00 37. .15 1SG 474
ATOM 474 C LYS 59 143. .257 36, .702 15, .829 1. .00 37, .15 1SG 475
ATOM 475 0 LYS 59 143. .719 37 .059 14 , .746 1. .00 37, .15 1SG 476
ATOM 476 N ILE 60 141. .945 36. .443 15. .997 1. 00 43. .17 1SG 477
ATOM 477 CA ILE 60 141. .041 36. .601 14. .894 1. .00 43. .17 1SG 478
ATOM 478 CB ILE 60 139. .909 35. .616 14. .886 1. .00 43. .17 1SG 479
ATOM 479 CG2 ILE 60 138. ,948 35. .996 13. .747 1. .00 43. .17 1SG 480
ATOM 480 CGI ILE 60 140. ,431 34. ,180 14. ,778 1. 00 43. .17 1SG 481
ATOM 481 CDl ILE 60 139. .331 33. .156 15. ,036 1. .00 43. ,17 1SG 482 ATOM 482 C ILE 60 140..414 37..946 15..061 1.,00 43..17 1SG 483
ATOM 483 O ILE 60 139. .691 38. .185 16, .027 1. .00 43 .17 1SG 484
ATOM 484 N SER 61 140. .750 38, .882 14, .150 1. .00 48. .24 1SG 485
ATOM 485 CA SER 61 140. .203 40. .208 14. .174 1. .00 48, .24 1SG 486
ATOM 486 CB SER 61 140. .978 41. .183 13, .271 1. .00 48 .24 1SG 487
ATOM 487 OG SER 61 142. .306 41. .341 13, .748 1. .00 48 .24 1SG 488
ATOM 488 C SER 61 138. .785 40. .189 13. .700 1. .00 48, .24 1SG 489
ATOM 489 O SER 61 137. .887 40. .675 14, .387 1. .00 48 .24 1SG 490
ATOM 490 N ALA 62 138, .547 39, .623 12, .496 1. .00 54 .48 1SG 491
ATOM 491 CA ALA 62 137, .212 39, .615 11, .973 1. .00 54, .48 1SG 492
ATOM 492 CB ALA 62 136. .931 40, .770 10. .996 1. .00 54, .48 1SG 493
ATOM 493 C ALA 62 136. .998 38 .343 11. .220 1. .00 54 .48 1SG 494
ATOM 494 O ALA 62 137, .900 37, .832 10. .557 1. .00 54, .48 1SG 495
ATOM 495 N PHE 63 135, .775 37, .791 11. .329 1. .00 65, .05 1SG 496
ATOM 496 CA PHE 63 135, .429 36 .589 10, .634 1. .00 65 .05 1SG 497
ATOM 497 CB PHE 63 135, .214 35, .426 11, .618 1. .00 65 .05 1SG 498
ATOM 498 CG PHE 63 135, .361 34, .007 10, .823 1. .00 65 .05 1SG 499
ATOM 499 CDl PHE 63 134, .550 33, .317 9, .923 1. .00 65, .05 1SG 500
ATOM 500 CD2 PHE 63 136, .070 32 .805 10, .491 1. .00 65 .05 1SG 501
ATOM 501 CE1 PHE 63 135, .505 32, .265 9, .830 1. .00 65 .05 1SG 502
ATOM 502 CE2 PHE 63 134, .876 33 , .278 10, .086 1. .00 65 .05 1SG 503
ATOM 503 CZ PHE 63 136, .105 33 .100 10 .701 1, .00 65 .05 1SG 504
ATOM 504 C PHE 63 134, .104 36, .912 10, .021 1, .00 65 .05 1SG 505
ATOM 505 O PHE 63 133, .067 36, .812 10, .675 1. .00 65 .05 1SG 506
ATOM 506 N SER 64 134, .079 37, .278 8, .729 1. .00 59, .44 1SG 507
ATOM 507 CA SER 64 132, .816 37 .715 8 .222 1, .00 5 .44 1SG 508
ATOM 508 CB SER 64 132, .909 38. .980 7, .351 1. .00 59 .44 1SG 509
ATOM 509 OG SER 64 133 , .657 38, .709 6, .175 1. .00 59 .44 1SG 510
ATOM 510 C SER 64 132, .214 36 .645 7 .382 1, .00 59 .44 1SG 511
ATOM 511 O SER 64 132, .882 36. .033 6, .551 1. .00 59 .44 lsσ 512
ATOM 512 N PHE 65 130, .917 36, .373 7, .628 1. .00 54 .98 1SG 513
ATOM 513 CA PHE 65 130, .182 35, .464 6, .800 1. .00 54, .98 1SG 514
ATOM 514 CB PHE 65 129, .395 34, .393 7 .578 1. .00 54 .98 1SG 515
ATOM 515 CG PHE 65 130, .338 33, .470 8, .267 1. .00 54 .98 1SG 516
ATOM 516 CDl PHE 65 130. .778 33, .744 9, .541 1. .00 54, .98 1SG 517
ATOM 517 CD2 PHE 65 130. .777 32, .326 7 .642 1. .00 54 .98 1SG 518
ATOM 518 CE1 PHE 65 131. .644 32, .890 10, .181 1. .00 54 .98 1SG 519
ATOM 519 CE2 PHE 65 131. .644 31. .469 8, .277 1. .00 54, .98 1SG 520
ATOM 520 CZ PHE 65 132. .078 31. .750 9, .549 1. ,00 54, .98 1SG 521
ATOM 521 C PHE 65 129, .145 36, .312 6 .132 1. .00 54 .98 1SG 522
ATOM 522 O PHE 65 128, .081 36, .559 6, .698 1. .00 54, .98 1SG 523
ATOM 523 N PRO 66 129. .438 36. .782 4 , .952 1. ,00 48, .86 1SG 524
ATOM 524 CA PRO 66 128, .515 37. .628 4, .246 1. .00 48, .86 1SG 525
ATOM 525 CD PRO 66 130. .816 37. .037 4, .566 1. .00 48, .86 1SG 526
ATOM 526 CB PRO 66 129. .303 38. .241 3, .092 1. .00 48. .86 1SG 527
ATOM 527 CG PRO 66 130. .755 38. .229 3. .597 1. ,00 48. .86 1SG 528
ATOM 528 C PRO 66 127. .269 36. .946 3. .795 1. .00 48. .86 1SG 529
ATOM 529 O PRO 66 126. .208 37. .567 3. .828 1. ,00 48, .86 1SG 530
ATOM 530 N ASN 67 127. ,361 35. .674 3. .367 1. ,00 38. .09 1SG 531
ATOM 531 CA ASN 67 126. .182 35. .054 2, .848 1. .00 38. .09 1SG 532
ATOM 532 CB ASN 67 126. .211 34. .890 1. .316 1. ,00 38. .09 1SG 533
ATOM 533 CG ASN 67 124. .841 34. ,428 0. .838 1. ,00 38. .09 1SG 534
ATOM 534 ODl ASN 67 124. ,375 33. ,342 1. .179 1. .00 38. .09 1SG 535
ATOM 535 ND2 ASN 67 124. .172 35. .280 0. .016 1. ,00 38. .09 1SG 536
ATOM 536 C ASN 67 126. ,050 33. .695 3. .444 1. ,00 38. .09 1SG 537
ATOM 537 O ASN 67 127. ,034 32. .987 3. ,650 1. .00 38. .09 1SG 538
ATOM 538 N THR 68 124. .798 33. .319 3. .764 1. .00 34. .19 1SG 539 ATOM 539 CA THR 68 124,.493 32..021 4.279 1..00 34,.19 1SG 540
ATOM 540 CB THR 68 124 .284 32 .010 5 .764 1, .00 34, .19 1SG 541
ATOM 541 OGl THR 68 124 .019 30 .690 6 .217 1. .00 34, .19 1SG 542
ATOM 542 CG2 THR 68 123 .114 32 .948 6 .103 1. .00 34, .19 1SG 543
ATOM 543 C THR 68 123, .206 31. .622 3 .635 1, .00 34, .19 1SG 544
ATOM 544 O THR 68 122, .411 32 .480 3 .250 1. .00 34, .19 1SG 545
ATOM 545 N SER 69 122, .973 30. .305 3 .465 1. .00 29, .48 1SG 546
ATOM 546 CA SER 69 121, .732 29. .921 2 .863 1, .00 29, .48 1SG 547
ATOM 547 CB SER 69 121. .786 29. .868 1 .326 1. .00 29. .48 1SG 548
ATOM 548 OG SER 69 120. .522 29, .482 0 .806 1. .00 29. .48 1SG 549
ATOM 549 C SER 69 121. .375 28, .547 3 .333 1. .00 29. .48 1SG 550
ATOM 550 O SER 69 122 .241 27 .732 3 .646 1 .00 29. .48 1SG 551
ATOM 551 N LEU 70 120 .060 28 .272 3 .419 1, .00 26. .32 1SG 552
ATOM 552 CA LEU 70 119 .607 26 .961 3 .765 1, .00 26, .32 1ΞG 553
ATOM 553 CB LEU 70 118 .802 26 .874 5 .074 1, .00 26, .32 1SG 554
ATOM 554 CG LEU 70 119 .663 27 .005 6 .343 1, .00 26, .32 1SG 555
ATOM 555 CD2 LEU 70 120 .817 25 .992 6 .337 1, .00 26, .32 1SG 556
ATOM 556 CDl LEU 70 118 .803 26 .906 7 .614 1, .00 26, .32 1SG 557
ATOM 557 C LEU 70 118, .711 26, .505 2 .666 1, .00 26, .32 1SG 558
ATOM 558 O LEU 70 117, .692 27 .130 2 .375 1, .00 26, .32 1SG 559
ATOM 559 N ALA 71 119, .076 25. .384 2 .023 1, .00 27, .45 1SG 560
ATOM 560 CA ALA 71 118, .249 24, .881 0 .973 1, .00 27, .45 1SG 561
ATOM 561 CB ALA 71 119, .004 24, .538 -0 .323 1, .00 27, .45 1SG 562
ATOM 562 C ALA 71 117, .622 23, .639 1 .500 1, .00 27, .45 1SG 563
ATOM 563 O ALA 71 118, .168 22, .978 2, .382 1, .00 27, .45 1SG 564
ATOM 564 N PHE 72 116, .420 23, .307 1, .002 1, .00 29, .74 1SG 565
ATOM 565 CA PHE 72 115 .780 22 .141 1 .521 1, .00 29 .74 1SG 566
ATOM 566 CB PHE 72 114 .311 22 .366 1 .913 1, .00 29, .74 1SG 567
ATOM 567 CG PHE 72 114, .373 22 .986 3 .268 1, .00 29, .74 1SG 568
ATOM 568 CDl PHE 72 114 .935 24, .227 3 .456 1, .00 29, .74 1SG 569
ATOM 569 CD2 PHE 72 113, .857 22 .320 4 .356 1, .00 29, .74 1SG 570
ATOM 570 CE1 PHE 72 114, .990 24, .783 4 .713 1, .00 29, .74 1SG 571
ATOM 571 CE2 PHE 72 113, .906 22, .874 5, .613 1, .00 29, .74 1SG 572
ATOM 572 CZ PHE 72 114, .477 24, .110 5, .794 1, .00 29. .74 1SG 573
ATOM 573 C PHE 72 115, .907 21, .011 0, .561 1. .00 29. .74 1SG 574
ATOM 574 O PHE 72 115. .666 21, .149 -0, .638 1, .00 29. .74 1SG 575
ATOM 575 N VAL 73 116. .353 19. .856 1, .092 1. .00 31. .95 1SG 576
ATOM 576 CA VAL 73 116. .462 18. .675 0, .295 1. .00 31. .95 1SG 577
ATOM 577 CB VAL 73 117, .693 17. .869 0, .587 1. .00 31. , 95 1SG 578
ATOM 578 CGI VAL 73 117. .672 16. .603 -0, .285 1. .00 31. .95 1SG 579
ATOM 579 CG2 VAL 73 118. .927 18. .758 0, .367 1. .00 31. ,95 1SG 580
ATOM 580 C VAL 73 115. .289 17. .841 0, .686 1, .00 31. .95 1SG 581
ATOM 581 O VAL 73 115. .233 17. .294 1, .786 1, .00 31. .95 1SG 582
ATOM 582 N PRO 74 114. .359 17, .723 -0, .216 1. .00 33. .39 1SG 583
ATOM 583 CA PRO 74 113. .126 17. .036 0, .049 1. .00 33. .39 1SG 584
ATOM 584 CD PRO 74 114. .655 17, .802 -1, .635 1. .00 33. ,39 1SG 585
ATOM 585 CB PRO 74 112. .402 16. .974 -1, .294 1. .00 33. .39 1SG 586
ATOM 586 CG PRO 74 113. .556 16. .967 -2, .314 1. ,00 33. .39 1SG 587
ATOM 587 C PRO 74 113. .356 15. .671 0, .616 1. .00 33. .39 1SG 588
ATOM 588 O PRO 74 114. .164 14. .920 0. .074 1. ,00 33. .39 1SG 589
ATOM 589 N GLY 75 112. .666 15. ,351 1. .728 1. ,00 31. 57 1SG 590
ATOM 590 CA GLY 75 112. .706 14. ,043 2. .313 1. ,00 31. 57 1SG 591
ATOM 591 C GLY 75 114. .064 13. ,782 2. .880 1. ,00 31. 57 1SG 592
ATOM 592 O GLY 75 114. .369 12. ,655 3. .264 1. 00 31. 57 1SG 593
ATOM 593 N VAL 76 114. .914 14. ,817 2. ,978 1. 00 31. 99 1SG 594
ATOM 594 CA VAL 76 116. ,243 14. ,583 3. ,460 1. 00 31. 99 1SG 595
ATOM 595 CB VAL 76 117. .301 14. ,879 2. .438 1. ,00 31. .99 1SG 596 r- oo σ. o H CN ro -* in vo r- oooo eenn Oo HH CCNN rroo ^^ mm iioo rr^- co cn o H cN rO 'H. in vo t- co cn o H CN ro -fi ιn iD r- co en o H (N ro <jι ιn vo r~ co en o H cN ro cn cn cn o o o O O O O oO oO oO HH HH HH HH HH H H H H H CN CN CN CN CN CN CN C CN CN fO rO ro rO rO i M-i πi rr'i. . n i ij ^i '. iii ^ '. ^ i. ^ i _fl. i_n. i_n. _in.
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ATOM 653 CB HIS 84 132.297 35,.121 0..087 1..00 38,.84 1SG 654
ATOM 654 NE2 HIS 84 135 .328 37, .289 0, .024 1. .00 38, .84 1SG 655
ATOM 655 CD2 HIS 84 134. .100 36. .930 0. .550 1. .00 38, .84 1SG 656
ATOM 656 CE1 HIS 84 135, .535 36, .425 -0. .954 1. .00 38, .84 1SG 657
ATOM 657 C HIS 84 132, .907 34, .285 2. .288 1. .00 38, .84 1SG 658
ATOM 658 O HIS 84 132, .901 35. .474 2. .602 1. .00 38, .84 1SG 659
ATOM 659 N GLY 85 133 .366 33 .332 3 .111 1. .00 33 .75 1SG 660
ATOM 660 CA GLY 85 133 .816 33. .701 4 .414 1, .00 33 .75 1SG 661
ATOM 661 C GLY 85 135 .132 34. .389 4 .278 1, .00 33 .75 1SG 662
ATOM 662 O GLY 85 135 .977 34. .000 3 .471 1. .00 33 .75 1SG 663
ATOM 663 N THR 86 135 .333 35. .440 5 .094 1. .00 30, .42 1SG 664
ATOM 664 CA THR 86 136 .571 36, .157 5 .089 1. .00 30, .42 1SG 665
ATOM 665 CB THR 86 136 .408 37, .604 4, .730 1. .00 30, .42 1SG 666
ATOM 666 OGl THR 86 135 .844 37. .729 3, .433 1. .00 30, .42 1SG 667
ATOM 667 CG2 THR 86 137, .784 38. .284 4, .786 1. .00 30, .42 1SG 668
ATOM 668 C THR 86 137, .097 36. .109 6. .485 1. .00 30. .42 1SG 669
ATOM 669 O THR 86 136, .432 36, .545 7, .423 1. .00 30. .42 1SG 670
ATOM 670 N ALA 87 138 .313 35 .559 6 .665 1 .00 29 .19 1SG 671
ATOM 671 CA ALA 87 138 .860 35, .515 7 .988 1. .00 29 .19 1SG 672
ATOM 672 CB ALA 87 139 .329 34, .112 8 .410 1. .00 29 .19 1SG 673
ATOM 673 C ALA 87 140 .063 36, .403 8 .016 1. .00 29 .19 1SG 674
ATOM 674 O ALA 87 141 .057 36, .153 7 .337 1. .00 29 .19 1SG 675
ATOM 675 N ASN 88 140, .014 37, .466 8, .836 1, .00 31 .19 1SG 676
ATOM 676 CA ASN 88 141 .145 38, .340 8, .922 1, .00 31 .19 1SG 677
ATOM 677 CB ASN 88 140, .764 39, .829 8, .982 1. .00 31 .19 1SG 678
ATOM 678 CG ASN 88 140, .116 40, .193 7, .655 1, .00 31 .19 1SG 679
ATOM 679 ODl ASN 88 140, .118 39. .399 6, .716 1. .00 31 .19 1SG 680
ATOM 680 ND2 ASN 88 139, .549 41. .426 7, .571 1 , .00 31, .19 1SG 681
ATOM 681 C ASN 88 141, .829 38. .003 10, .205 1. .00 31, .19 1SG 682
ATOM 682 O ASN 88 141 .220 38, .032 11 .273 1, .00 31 .19 1SG 683
ATOM 683 N ILE 89 143 .128 37, .666 10 .124 1, .00 34 .18 1SG 684
ATOM 684 CA ILE 89 143 .853 37, .271 11 .297 1, .00 34 .18 1SG 685
ATOM 685 CB ILE 89 144 .393 35, .873 11, .199 1, .00 34 .18 1SG 686
ATOM 686 CG2 ILE 89 145 .302 35, .618 12, .412 1, .00 34 .18 1SG 687
ATOM 687 CGI ILE 89 143, .241 34. .865 11, .063 1. .00 34, .18 1SG 688
ATOM 688 CDl ILE 89 143, .702 33. .465 10, .659 1, .00 34, .18 1SG 689
ATOM 689 C ILE 89 145, .026 38. .187 11, .433 1. .00 34, .18 1SG 690
ATOM 690 O ILE 89 145, .546 38. .696 10, .442 1. .00 34 , .18 1SG 691
ATOM 691 N SER 90 145, .450 38. .448 12 , .687 1. .00 37. .65 1SG 692
ATOM 692 CA SER 90 146. .576 39. .309 12. .903 1. .00 37. .65 1SG 693
ATOM 693 CB SER 90 146, .160 40, .690 13, .430 1. .00 37. .65 1SG 694
ATOM 694 OG SER 90 147, .282 41. .554 13, .457 1. .00 37, .65 1SG 695
ATOM 695 C SER 90 147, .442 38. .647 13 , .932 1. .00 37, .65 1SG 696
ATOM 696 O SER 90 146, .940 37. .966 14 , .825 1. .00 37, .65 1SG 697
ATOM 697 N THR 91 148, .780 38. .804 13 , .821 1. .00 38. .69 1SG 698
ATOM 698 CA THR 91 149, .648 38. .128 14 , .745 1. .00 38. .69 1SG 699
ATOM 699 CB THR 91 150, .016 36. .750 14. .283 1. .00 38. .69 1SG 700
ATOM 700 OGl THR 91 150. .864 36. ,833 13. .148 1. .00 38. .69 1SG 701
ATOM 701 CG2 THR 91 148. .731 36. .007 13. .889 1. ,00 38. .69 1SG 702
ATOM 702 C THR 91 150. .956 38. ,857 14. .810 1. ,00 38. ,69 1SG 703
ATOM 703 O THR 91 151. ,119 39. ,944 14. ,258 1. .00 38. ,69 1SG 704
ATOM 704 N ASP 92 151. .924 38. .251 15. .533 1. .00 39. .47 1SG 705
ATOM 705 CA ASP 92 153. .260 38. .761 15. .647 1. .00 39. .47 1SG 706
ATOM 706 CB ASP 92 153. .660 39. .134 17. .085 1. .00 39. .47 1SG 707
ATOM 707 CG ASP 92 152. .871 40. .372 17. .488 1. ,00 39. .47 1SG 708
ATOM 708 ODl ASP 92 152. .234 40. .985 16. .591 1. ,00 39. .47 1SG 709
ATOM 709 OD2 ASP 92 152. .892 40. .718 18. .699 1. ,00 39. ,47 1SG 710 ATOM 710 C ASP 92 154..174 37..657 15.,209 1.00 39.,47 1SG 711
ATOM 711 O ASP 92 153. .765 36. .500 15. .140 1. .00 39. .47 1SG 712
ATOM 712 N TRP 93 155. .433 37. ,997 14. .861 1. .00 41. .82 1SG 713
ATOM 713 CA TRP 93 156. .380 37. .003 14. .448 1. .00 41. ,82 1SG 714
ATOM 714 CB TRP 93 156. .434 36. .817 12. .922 1. .00 41. .82 1SG 715
ATOM 715 CG TRP 93 156. .668 38. .119 12. .199 1. .00 41. .82 1SG 716
ATOM 716 CD2 TRP 93 157. .947 38. ,760 12. .079 1. .00 41. .82 1SG 717
ATOM 717 CDl TRP 93 155. .764 38. .949 11. .604 1. .00 41. .82 1SG 718
ATOM 718 NE1 TRP 93 156. .398 40. , 073 11. .130 1. ,00 41. .82 1SG 719
ATOM 719 CE2 TRP 93 157. .743 39. .970 11, .418 1. .00 41. .82 1SG 720
ATOM 720 CE3 TRP 93 159, .190 38. .377 12, .492 1. .00 41. .82 1SG 721
ATOM 721 CZ2 TRP 93 158, .783 40. .818 11, .165 1. .00 41. .82 1SG 722
ATOM 722 CZ3 TRP 93 160. .234 39. .233 12, .231 1. .00 41. .82 1SG 723
ATOM 723 CH2 TRP 93 160. .036 40. .431 11, .582 1. .00 41. .82 1SG 724
ATOM 724 C TRP 93 157. .734 37. .467 14 , .884 1. .00 41. .82 1SG 725
ATOM 725 O TRP 93 157, .923 38. .638 15 .213 1. .00 41. .82 1SG 726
ATOM 726 N GLY 94 158, .718 36. .542 14, .907 1. .00 44. .53 1SG 727
ATOM 727 CA GLY 94 160, .055 36. .919 15, .258 1. .00 44. .53 1SG 728
ATOM 728 C GLY 94 160 .967 35, .909 14 .641 1. .00 44. .53 1SG 729
ATOM 729 O GLY 94 160, .676 34. .715 14, .652 1. .00 44. .53 1SG 730
ATOM 730 N PHE 95 162, .099 36. .372 14 , .072 1. .00 50. .15 1SG 731
ATOM 731 CA PHE 95 163 .040 35. .466 13 .486 1, .00 50, .15 1SG 732
ATOM 732 CB PHE 95 162, .920 35. .304 11, .958 1, .00 50, .15 1SG 733
ATOM 733 CG PHE 95 163. .308 36. .582 11, .301 1. .00 50. .15 1SG 734
ATOM 734 CDl PHE 95 162 .377 37. .569 11 .083 1. .00 50, .15 1SG 735
ATOM 735 CD2 PHE 95 164 .606 36. .793 10, .897 1, .00 50, .15 1SG 736
ATOM 736 CE1 PHE 95 162 .732 38. .750 10 .475 1 .00 50 .15 1SG 737
ATOM 737 CE2 PHE 95 164 .969 37. .971 10 .288 1. .00 50, .15 1SG 738
ATOM 738 CZ PHE 95 164 .031 38. .952 10 .076 1. .00 50, .15 1SG 739
ATOM 739 C PHE 95 164 .402 36. .004 13 .770 1 .00 50 .15 1SG 740
ATOM 740 O PHE 95 164 .592 37, .217 13 .865 1. .00 50 .15 1SG 741
ATOM 741 N GLU 96 165, .389 35, .105 13 .966 1. .00 53, .68 1SG 742
ATOM 742 CA GLU 96 166 .688 35 .617 14 .279 1 .00 53 .68 1SG 743
ATOM 743 CB GLU 96 167 .115 35, .367 15 .738 1. .00 53 .68 1SG 744
ATOM 744 CG GLU 96 168, .361 36, .135 16 .181 1. .00 53, .68 1SG 745
ATOM 745 CD GLU 96 168 .636 35. .777 17 .636 1 .00 53 .68 1SG 746
ATOM 746 OEl GLU 96 167 .862 34. .959 18 .199 1. .00 53. .68 1SG 747
ATOM 747 OE2 GLU 96 169, .621 36 , .320 18 .204 1. .00 53, .68 1SG 748
ATOM 748 C GLU 96 167 .717 34. .952 13 .429 1. .00 53 .68 1SG 749
ATOM 749 O GLU 96 167 .773 33. .725 13 .339 1. .00 53, .68 1SG 750
ATOM 750 N SER 97 168, .532 35. .784 12, .752 1. .00 55, .71 1SG 751
ATOM 751 CA SER 97 169 .715 35. .323 12 .094 1. .00 55, .71 1SG 752
ATOM 752 CB SER 97 170, .200 36. .274 10 .985 1, .00 55, .71 1SG 753
ATOM 753 OG SER 97 170 .566 37. .528 11 .542 1 .00 55 .71 1SG 754
ATOM 754 C SER 97 170 .671 35. .380 13 .233 1. .00 55, .71 .1SG 755
ATOM 755 O SER 97 170, .279 35. .991 14 .222 1. .00 55, .71 1SG 756
ATOM 756 N PRO 98 171 .855 34, .814 13 .193 1. .00 53, .83 1SG 757
ATOM 757 CA PRO 98 172 .701 34, .761 14 .365 1, .00 53, .83 1SG 758
ATOM 758 CD PRO 98 172, .635 34. .771 11, .966 1, .00 53, .83 1SG 759
ATOM 759 CB PRO 98 174 .070 34. .315 13 .863 1 .00 53 .83 1SG 760
ATOM 760 CG PRO 98 174 .103 34. .843 12 .418 1. .00 53, .83 1SG 761
ATOM 761 C PRO 98 172, .795 36. .043 15, .137 1. .00 53, .83 1SG 762
ATOM 762 O PRO 98 172 .348 36. .064 16 .283 1 .00 53, .83 1SG 763
ATOM 763 N LEU 99 173 .315 37. .118 14 .523 1. .00 49, .00 1SG 764
ATOM 764 CA LEU 99 173, .442 38. .384 15, .181 1. .00 49, ,00 1SG 765
ATOM 765 CB LEU 99 174, .394 39. .339 14 .443 1 .00 49, .00 1SG 766
ATOM 766 CG LEU 99 174, .544 40. .706 15 .136 1. .00 49, .00 1SG 767 ATOM 767 CD2 LEU 99 175..292 41..708 14..241 1..00 49..00 1SG 768
ATOM 768 CDl LEU 99 175. .180 40. .562 16. .527 1. ,00 49. .00 1SG 769
ATOM 769 C LEU 99 172. .135 39. .103 15. .331 1. ,00 49. .00 1SG 770
ATOM 770 O LEU 99 171. .884 39. .726 16. .362 1. ,00 49, .00 1SG 771
ATOM 771 N PHE 100 171, .256 39. .052 14. .313 1. .00 43, .90 1SG 772
ATOM 772 CA PHE 100 170. .171 39. .990 14. .381 1. ,00 43, .90 1SG 773
ATOM 773 CB PHE 100 169, .956 40. .723 13. .045 1. ,00 43, .90 1SG 774
ATOM 774 CG PHE 100 169, .197 41. .976 13. .318 1. ,00 43, .90 1SG 775
ATOM 775 CDl PHE 100 167. .825 41. .984 13. .408 1. .00 43, .90 1SG 776
ATOM 776 CD2 PHE 100 169. .881 43. .159 13. .482 1. .00 43. .90 1SG 777
ATOM 111 CE1 PHE 100 167, .156 43. .159 13. .660 1. .00 43. .90 1SG 778
ATOM 778 CE2 PHE 100 169, .215 44. .334 13 , .734 1. .00 43. .90 1SG 779
ATOM 779 CZ PHE 100 167, .846 44. .336 13. .823 1. .00 43, .90 1SG 780
ATOM 780 C PHE 100 168. .875 39. .357 14. .772 1. .00 43, .90 1SG 781
ATOM 781 O PHE 100 168, .566 38. .222 14. .409 1. .00 43, .90 1SG 782
ATOM 782 N GLN 101 168, .074 40. .118 15. .551 1. .00 36, .91 1SG 783
ATOM 783 CA GLN 101 166, .782 39, .666 15. .973 1. .00 36, .91 1SG 784
ATOM 784 CB GLN 101 166, .600 39. .679 17. .500 1. .00 36, .91 1SG 785
ATOM 785 CG GLN 101 167, .524 38. .702 18. .230 1. .00 36, .91 1SG 786
ATOM 786 CD GLN 101 167, .245 38. .813 19. .722 1. .00 36 .91 1SG 787
ATOM 787 OEl GLN 101 166, .410 39. .606 20. .154 1. .00 36 .91 1SG 788
ATOM 788 NE2 GLN 101 167, .966 37. .995 20. .536 1. .00 36 .91 1SG 789
ATOM 789 C GLN 101 165, .772 40. .607 15. .393 1. .00 36 .91 1SG 790
ATOM 790 O GLN 101 165, .822 41. .811 15. .640 1. .00 36 .91 1SG 791
ATOM 791 N ASP 102 164, .826 40. .073 14, .594 1. .00 32 .28 1SG 792
ATOM 792 CA ASP 102 163, .826 40, .900 13 , .979 1. .00 32 .28 1SG 793
ATOM 793 CB ASP 102 163, .747 40, .728 12, .452 1. .00 32 .28 1SG 794
ATOM 794 CG ASP 102 164, .923 41. .463 11, .825 1. .00 32 .28 1SG 795
ATOM 795 ODl ASP 102 165, .006 42. .705 12, .019 1. .00 32 .28 1SG 796
ATOM 796 OD2 ASP 102 165 .754 40, .798 11, .151 1. .00 32 .28 1SG 797
ATOM 797 C ASP 102 162, .491 40, .531 14, .536 1, .00 32 .28 1SG 798
ATOM 798 O ASP 102 162, .194 39. .358 14, .761 1. .00 32 .28 1SG 799
ATOM 799 N THR 103 161, .651 41. .551 14 , .789 1. .00 28 .80 1SG 800
ATOM 800 CA THR 103 160, .339 41. .308 15, .311 1. .00 28 .80 1SG 801
ATOM 801 CB THR 103 160, .211 41. .617 16. .773 1. .00 28 .80 1SG 802
ATOM 802 OGl THR 103 158, .947 41. .187 17. .257 1. .00 28 .80 1SG 803
ATOM 803 CG2 THR 103 160, .372 43. .133 16, .972 1. .00 28 .80 1SG 804
ATOM 804 C THR 103 159, .390 42 , .209 14 , .588 1, .00 28 .80 1SG 805
ATOM 805 O THR 103 159, .796 43. .194 13, .973 1. .00 28 .80 1SG 806
ATOM 806 N GLY 104 158, .085 41. .878 14 , .634 1. .00 25, .66 1SG 807
ATOM 807 CA GLY 104 157, .121 42. .725 13, .997 1. .00 25 .66 1SG 808
ATOM 808 C GLY 104 155, .827 41. .985 13 , .924 1. .00 25, .66 1SG 809
ATOM 809 O GLY 104 155, .786 40. .761 14 , .032 1. .00 25, .66 1SG 810
ATOM 810 N GLY 105 154, .723 42. .734 13, .734 1. .00 26, .24 1SG 811
ATOM 811 CA GLY 105 153, .430 42. .125 13, .631 1. .00 26, .24 1SG 812
ATOM 812 C GLY 105 153, .232 41. .724 12 , .205 1. .00 26, .24 1SG 813
ATOM 813 O GLY 105 153, .993 42. .126 11, .326 1. .00 26, .24 1SG 814
ATOM 814 N ALA 106 152, .186 40. .916 11, .939 1. .00 29, .32 1SG 815
ATOM 815 CA ALA 106 151, .920 40. .501 10, .592 1. .00 29, .32 1SG 816
ATOM 816 CB ALA 106 152. .520 39, .129 10, .239 1. .00 29, .32 1SG 817
ATOM 817 C ALA 106 150. .437 40. .392 10. .421 1. .00 29, .32 1SG 818
ATOM 818 O ALA 106 149, .703 40. .240 11. .395 1. .00 29 .32 1SG 819
ATOM 819 N ASP 107 149, .963 40. .495 9. .161 1. .00 33, .88 1SG 820
ATOM 820 CA ASP 107 148, .560 40. .397 8. .866 1. .00 33, .88 1SG 821
ATOM 821 CB ASP 107 147, .986 41. .640 8. .164 1. .00 33 .88 1SG 822
ATOM 822 CG ASP 107 147, .924 42. ,780 9. .171 1. .00 33 .88 1SG 823
ATOM 823 ODl ASP 107 147, .995 42. ,494 10. .396 1. .00 33, .88 1SG 824 ATOM 824 OD2 ASP 107 147..798 43..953 8,.728 1..00 33,.88 1SG 825
ATOM 825 C ASP 107 148. .361 39. .240 7. ,935 1. .00 33. .88 1SG 826
ATOM 826 O ASP 107 149. .168 39. .007 7. .037 1. .00 33, .88 1SG 827
ATOM 827 N LEU 108 147, .273 38. .471 8. .151 1. .00 38, .93 1SG 828
ATOM 828 CA LEU 108 146, .955 37. .345 7, .322 1. .00 38 .93 1SG 829
ATOM 829 CB LEU 108 146. .936 36. .007 8, .077 1. .00 38, .93 1SG 830
ATOM 830 CG LEU 108 146. .594 34. .812 7, .168 1, .00 38, .93 1SG 831
ATOM 831 CD2 LEU 108 146, .032 33, .625 7, .961 1. .00 38 .93 1SG 832
ATOM 832 CDl LEU 108 147, .773 34, .446 6 .258 1. .00 38 .93 1SG 833
ATOM 833 C LEU 108 145. .553 37. .543 6, .841 1. .00 38, .93 1SG 834
ATOM 834 O LEU 108 144. .731 38. .134 7, .539 1. .00 38, .93 1SG 835
ATOM 835 N PHE 109 145, .243 37, .061 5 .620 1. .00 40 .38 1SG 836
ATOM 836 CA PHE 109 143, .906 37, .219 5, .128 1. .00 40, .38 1SG 837
ATOM 837 CB PHE 109 143 , .850 38. .248 3, .983 1. .00 40, .38 1SG 838
ATOM 838 CG PHE 109 142, .485 38. .839 3, .903 1. .00 40 .38 1SG 839
ATOM 839 CDl PHE 109 141, .455 38, .210 3 .247 1, .00 40 .38 1SG 840
ATOM 840 CD2 PHE 109 142. .250 40. .060 4. .493 1. .00 40, .38 1SG 841
ATOM ' 841 CE1 PHE 109 140. .212 38. .798 3, .194 1. .00 40 .38 1SG 842
ATOM 842 CE2 PHE 109 141, .010 40. .649 4, .442 1, .00 40 .38 1SG 843
ATOM 843 CZ PHE 109 139, .983 40. .014 3, .789 1. .00 40 .38 1SG 844
ATOM 844 C PHE 109 143 , .515 35. .880 4. .573 1. .00 40 .38 1SG 845
ATOM 845 O PHE 109 144, .235 35. .297 3, .763 1, .00 40 .38 1SG 846
ATOM 846 N LEU 110 142, .357 35, .350 5 .007 1, .00 38 .13 1SG 847
ATOM 847 CA LEU 110 141, .906 34, .068 4 .547 1. .00 38 .13 1SG 848
ATOM 848 CB LEU 110 141. .664 33. .124 5, .739 1. .00 38, .13 1SG 849
ATOM 849 CG LEU 110 141, .395 31, .661 5, .368 1, .00 38 .13 1SG 850
ATOM 850 CD2 LEU 110 142, .624 31, .030 4, .696 1, .00 38 .13 1SG 851
ATOM 851 CDl LEU 110 140, .105 31, .525 4 .557 1, .00 38 .13 1SG 852
ATOM 852 C LEU 110 140. .602 34. .349 3, .867 1. .00 38, .13 1SG 853
ATOM 853 O LEU 110 139. .691 34. .900 4, .482 1. .00 38 .13 1SG 854
ATOM 854 N SER 111 140. .469 33, .993 2 .574 1, .00 33 .60 1SG 855
ATOM 855 CA SER 111 139. .253 34. .342 1, .894 1. .00 33, .60 1SG 856
ATOM 856 CB SER 111 139. .431 35. .454 0, .849 1. .00 33, .60 1SG 857
ATOM 857 OG SER 111 139. .879 36 , .647 1, .469 1. .00 33 .60 1SG 858
ATOM 858 C SER 111 138, .757 33, .166 1, .125 1, .00 33 .60 1SG 859
ATOM 859 O SER 111 139. .453 32. .166 0, .959 1. .00 33, .60 1SG 860
ATOM 860 N GLY 112 137. .505 33. .277 0, .636 1. .00 31, .59 1SG 861
ATOM 861 CA GLY 112 136. .935 32. .253 -0, .186 1, .00 31, .59 1SG 862
ATOM 862 C GLY 112 136. .694 31, .032 0, .639 1. .00 31 .59 1SG 863
ATOM 863 O GLY 112 136. .899 29. .916 0, .164 1. .00 31, .59 1SG 864
ATOM 864 N VAL 113 136. .262 31. .212 1, .902 1. .00 32, .55 1SG 865
ATOM 865 CA VAL 113 135. .989 30. .082 2, .747 1. .00 32, .55 1SG 866
ATOM 866 CB VAL 113 135, .905 30. .419 4, .206 1. .00 32, .55 1SG 867
ATOM 867 CGI VAL 113 135. .580 29. .133 4. .983 1. .00 32. .55 1SG 868
ATOM 868 CG2 VAL 113 137. .197 31. .114 4, .643 1. .00 32. .55 1SG 869
ATOM 869 C VAL 113 134. .624 29. .579 2, .398 1. .00 32. .55 1SG 870
ATOM 870 O VAL 113 133. .693 30. ,363 2. .224 1. .00 32. .55 1SG 871
ATOM 871 N TYR 114 134. .479 28. .242 2. .291 1. .00 34. .61 1SG 872
ATOM 872 CA TYR 114 133. .220 27. .647 1, .941 1. .00 34. .61 1SG 873
ATOM 873 CB TYR 114 133. .358 26. .915 0. .590 1. .00 34, .61 1SG 874
ATOM 874 CG TYR 114 132. .044 26. .565 -0. .017 1. .00 34. .61 1SG 875
ATOM 875 CDl TYR 114 131. .362 27. .506 -0. .753 1. ,00 34. .61 1SG 876
ATOM 876 CD2 TYR 114 131. .499 25. ,311 0. .131 1. ,00 34. .61 1SG 877
ATOM 877 CE1 TYR 114 130. .152 27. ,209 -1. .334 1. .00 34. .61 1SG 878
ATOM 878 CE2 TYR 114 130. ,291 25. 009 -0. .450 1. 00 34. .61 1SG 879
ATOM 879 CZ TYR 114 129. ,615 25. ,955 -1. .183 1. .00 34. .61 1SG 880
ATOM 880 OH TYR 114 128. ,374 25. ,639 -1. .776 1. .00 34. .61 1SG 881 ATOM 881 C TYR 114 132.,915 26..655 3.,030 1..00 34..61 1SG 882
ATOM 882 O TYR 114 133. .706 25. .753 3. ,298 1. .00 34. .61 1SG 883
ATOM 883 N PHE 115 131. .755 26. ,813 3. .700 1. .00 37, .18 1SG 884
ATOM 884 CA PHE 115 131. .368 25. .970 4. .800 1. .00 37, .18 1SG 885
ATOM 885 CB PHE 115 131. .134 26. .817 6. .062 1. .00 37 .18 1SG 886
ATOM 886 CG PHE 115 130. .665 25. .966 7. .184 1. .00 37, .18 1SG 887
ATOM 887 CDl PHE 115 129. .324 25. .694 7, .327 1. .00 37, .18 1SG 888
ATOM 888 CD2 PHE 115 131. .559 25, .448 8. .090 1, .00 37 .18 1SG 889
ATOM 889 CE1 PHE 115 128. .875 24. .912 8. .362 1. .00 37, .18 1SG 890
ATOM 890 CE2 PHE 115 131. .115 24. ,667 9. .129 1. .00 37, .18 1SG 891
ATOM 891 CZ PHE 115 129. .774 24. .399 9. .264 1, .00 37 .18 1SG 892
ATOM 892 C PHE 115 130. .053 25. .346 4. .445 1, .00 37, .18 1SG 893
ATOM 893 O PHE 115 129. .083 26. .048 4, .167 1. .00 37 .18 1SG 894
ATOM 894 N THR 116 129. .978 24. .000 4. .457 1, .00 36, .09 1SG 895
ATOM 895 CA THR 116 128. .737 23. ,351 4. .143 1. .00 36, .09 1SG 896
ATOM 896 CB THR 116 128. .799 22. .482 2. .923 1, .00 36 .09 1SG 897
ATOM 897 OGl THR 116 129. .737 21. .433 3 .117 1 .00 36 .09 1SG 898
ATOM 898 CG2 THR 116 129. .209 23. .343 1. .722 1. .00 36, .09 1SG 899
ATOM 899 C THR 116 128. .404 22. .441 5. .279 1. .00 36 .09 1SG 900
ATOM 900 O THR 116 129. .284 21. .801 5 .850 1 .00 36 .09 1SG 901
ATOM 901 N GLY 117 127. .107 22. .354 5. .636 1. .00 33 .49 1SG 902
ATOM 902 CA GLY 117 126. .728 21. .489 6. .717 1. .00 33 .49 1SG 903
ATOM 903 C GLY 117 125. .364 20, .943 6 .426 1, .00 33 .49 1SG 904
ATOM 904 O GLY 117 124. .545 21, .592 5, .777 1. .00 33 .49 1SG 905
ATOM 905 N ILE 118 125, .077 19, .726 6, .934 1 .00 32 .06 1SG 906
ATOM 906 CA ILE 118 123, .809 19, .102 6 .690 1 .00 32 .06 1SG 907
ATOM 907 CB ILE 118 123, .920 17. .690 6, .194 1, .00 32, .06 1SG 908
ATOM 908 CG2 ILE 118 122, .500 17. .103 6 .123 1, .00 32 .06 1SG 909
ATOM 909 CGI ILE 118 124 .670 17 .651 4 .852 1 .00 32 .06 1SG 910
ATOM 910 CDl ILE 118 123. .984 18, .456 3 .749 1, .00 32 .06 1SG 911
ATOM 911 C ILE 118 123 , .064 19, .057 7. .986 1, .00 32 .06 1SG 912
ATOM 912 O ILE 118 123 .612 18, .705 9 .030 1 .00 32 .06 1SG 913
ATOM 913 N ILE 119 121. .774 19, .435 7, .929 1, .00 31 .31 1SG 914
ATOM 914 CA ILE 119 120, .901 19 .516 9 .066 1 .00 31 .31 1SG 915
ATOM 915 CB ILE 119 120, .193 20, .845 9 .067 1 .00 31 .31 1SG 916
ATOM 916 CG2 ILE 119 118. .910 20. .768 9, .902 1, .00 31, .31 1SG 917
ATOM 917 CGI ILE 119 121. .175 21, .965 9 .447 1 .00 31 .31 1SG 918
ATOM 918 CDl ILE 119 120 .634 23 .369 9 .183 1 .00 31 .31 1SG 919
ATOM 919 C ILE 119 119. .865 18. .438 8, .942 1, .00 31, .31 1SG 920
ATOM 920 O ILE 119 119. .136 18. .374 7, .955 1, .00 31 .31 1SG 921
ATOM 921 N ILE 120 119. .769 17 .555 9 .961 1 .00 33 .25 1SG 922
ATOM 922 CA ILE 120 118, .806 16. .490 9, .920 1 .00 33 .25 1SG 923
ATOM 923 CB ILE 120 119. .402 15. .130 10, .161 1, .00 33. .25 1SG 924
ATOM 924 CG2 ILE 120 120. .056 15. .115 11 .553 1 .00 33 .25 1SG 925
ATOM 925 CGI ILE 120 118. .344 14. .035 9, .945 1, .00 33, .25 1SG 926
ATOM 926 CDl ILE 120 118. .928 12, .625 9 .885 1, .00 33 .25 1SG 927
ATOM 927 C ILE 120 117. .789 16, .737 10 .989 1 .00 33 .25 1SG 928
ATOM 928 O ILE 120 118. .128 16, .971 12, .148 1. .00 33, .25 1SG 929
ATOM 929 N LEU 121 116. .493 16, .698 10, .617 1. .00 36, .13 1SG 930
ATOM 930 CA LEU 121 115 .462 16 .973 11 .574 1 .00 36 .13 1SG 931
ATOM 931 CB LEU 121 114. .386 17, .934 11, .040 1. .00 36, .13 1SG 932
ATOM 932 CG LEU 121 114. .922 19, .337 10, .702 1. .00 36, .13 1SG 933
ATOM 933 CD2 LEU 121 115. .670 19, .952 11, .893 1. .00 36, .13 1SG 934
ATOM 934 CDl LEU 121 113. .806 20. .249 10, .175 1. .00 36, .13 1SG 935
ATOM 935 C LEU 121 114. .769 15 .695 11 .927 1. .00 36 .13 1SG 936
ATOM 936 O LEU 121 114. .495 14. .862 11, .066 1. .00 36, .13 1SG 937
ATOM 937 N THR 122 114. .483 15. .504 13 , .229 1. .00 38, .82 1SG 938 ATOM 938 CA THR 122 113..768 14..336 13..651 1..00 38..82 1SG 939
ATOM 939 CB THR 122 114. .645 13. .155 13, .965 1. .00 38. .82 1SG 940
ATOM 940 OGl THR 122 115. .574 13 .465 14, .988 1. .00 38, .82 1SG 941
ATOM 941 CG2 THR 122 115. .395 12 .757 12, .682 1, .00 38, .82 1SG 942
ATOM 942 C THR 122 112. .947 14 .716 14, .844 1, .00 38, .82 1SG 943
ATOM 943 O THR 122 112. .878 15. .888 15, .208 1. .00 38, .82 1SG 944
ATOM 944 N ARG 123 112, .259 13, .737 15, .462 1. .00 41. .30 1SG 945
ATOM 945 CA ARG 123 111, .432 i4, .059 16. .591 1, .00 41. .30 1SG 946
ATOM 946 CB ARG 123 109, .929 14, .067 16. .274 1, .00 41. .30 1SG 947
ATOM 947 CG ARG 123 109, .063 14, .430 17, .482 1. .00 41. .30 1SG 948
ATOM 948 CD ARG 123 107, .600 14, .014 17, .333 1. .00 41. .30 1SG 949
ATOM 949 NE ARG 123 107, .487 12 .631 17 .875 1. .00 41. .30 1SG 950
ATOM 950 CZ ARG 123 107, .820 11 .562 17 .093 1, .00 41, .30 1SG 951
ATOM 951 NHl ARG 123 108, .246 11 .761 15, .814 1. .00 41, .30 1SG 952
ATOM 952 NH2 ARG 123 107, .735 10 .295 17, .596 1. .00 41, .30 1SG 953
ATOM 953 C ARG 123 111, .619 12 .991 17. .617 1, .00 41. .30 1SG 954
ATOM 954 O ARG 123 112, .055 11, .884 17. .304 1. .00 41, .30 1SG 955
ATOM 955 N ASN 124 111. .306 13, .306 18, .890 1. .00 40, .99 1SG 956
ATOM 956 CA ASN 124 Ill, .371 12, .275 19, .879 1, .00 40, .99 1SG 957
ATOM 957 CB ASN 124 112 , .459 12, .444 20, .966 1. .00 40. .99 1SG 958
ATOM 958 CG ASN 124 112, .197 13 .654 21, .845 1. .00 40, .99 1SG 959
ATOM 959 ODl ASN 124 111, .914 14 .751 21 .372 1. .00 40, .99 1SG 960
ATOM 960 ND2 ASN 124 112, .317 13 .449 23 .183 1, .00 40, .99 1SG 961
ATOM 961 C ASN 124 110, .016 12 .190 20, .506 1, .00 40, .99 1SG 962
ATOM 962 O ASN • 124 109, .218 13, .120 20, .426 1. .00 40, .99 1SG 963
ATOM 963 N ASP 125 109, .729 11, .048 21, .148 1, .00 39. .54 1SG 964
ATOM 964 CA ASP 125 108, .450 10, .740 21, .720 1, .00 39. .54 1SG 965
ATOM 965 CB ASP 125 108, .409 9, .353 22, .384 1. .00 39. .54 1SG 966
ATOM 966 CG ASP 125 108. .397 8, .305 21, .281 1. .00 39. .54 1SG 967
ATOM 967 ODl ASP 125 107. .930 8, .639 20. .159 1. .00 39. .54 1SG 968
ATOM 968 OD2 ASP 125 108, .849 7 .158 21 .543 1. .00 39. .54 1SG 969
ATOM 969 C ASP 125 108, .111 11 .748 22. .771 1. .00 39. .54 1SG 970
ATOM 970 O ASP 125 106, .935 11, .959 23. .059 1. .00 39, .54 1SG 971
ATOM 971 N PHE 126 109, .126 12, .398 23. .373 1. .00 38, .01 1SG 972
ATOM 972 CA PHE 126 108, .869 13, .387 24, .384 1. .00 38. .01 1SG 973
ATOM 973 CB PHE 126 110. .128 14, .102 24, .894 1. .00 38. .01 1SG 974
ATOM 974 CG PHE 126 109. .753 14, .777 26. .165 1. .00 38. .01 1SG 975
ATOM 975 CDl PHE 126 109. .855 14, .103 27, .359 1. .00 38. .01 1SG 976
ATOM 976 CD2 PHE 126 109. .286 16. .069 26. .171 1. .00 38. .01 1SG 977
ATOM 977 CE1 PHE 126 109. .507 14 .712 28. .541 1, .00 38. .01 1SG 978
ATOM 978 CE2 PHE 126 108. .937 16, .686 27. .349 1. .00 38. .01 1SG 979
ATOM 979 CZ PHE 126 109. .048 16 .007 28. .538 1. .00 38. .01 1SG 980
ATOM 980 C PHE 126 108. .005 14, .397 23. .704 1. .00 38. .01 1SG 981
ATOM 981 O PHE 126 107. .164 15, .047 24. .326 1. ,00 38. .01 1SG 982
ATOM 982 N GLY 127 108. .200 14, .543 22. .380 1. ,00 37. ,08 1SG 983
ATOM 983 CA GLY 127 107. .354 15. .412 21. .621 1. ,00 37. .08 1SG 984
ATOM 984 C GLY 127 108. .132 16. .597 21. .164 1. .00 37. .08 1SG 985
ATOM 985 O GLY 127 107. .590 17. .467 20. .484 1. .00 37. ,08 1SG 986
ATOM 986 N HIS 128 109. .427 16, .662 21. .524 1. .00 39. .10 1SG 987
ATOM 987 CA HIS 128 110, .224 17, .772 21. .096 1. .00 39. .10 1SG 988
ATOM 988 NDl HIS 128 110. .792 20. .177 23. .517 1. .00 39. .10 1SG 989
ATOM 989 CG HIS 128 110. .859 18. .814 23. .332 1. .00 39. .10 1SG 990
ATOM 990 CB HIS 128 111. .347 18. .156 22. .076 1. ,00 39. .10 1SG 991
ATOM 991 NE2 HIS 128 110. .065 19. .245 25. ,400 1. ,00 39. .10 1SG 992
ATOM 992 CD2 HIS 128 110. .411 18. .262 24. ,491 1. 00 39. .10 1SG 993
ATOM 993 CE1 HIS 128 110. .311 20. .379 24. .770 1. 00 39. 10 1SG 994
ATOM 994 C HIS 128 110. .878 17. ,420 19. .799 1. 00 39. 10 1SG 995 ATOM 995 O HIS 128 111.141 16,.259 19..493 1..00 39.10 1SG 996
ATOM 996 N PRO 129 111 .095 18, .422 18. .998 1. .00 41 .11 1SG 997
ATOM 997 CA PRO 129 111 .777 18, .207 17. .753 1. .00 41 .11 1SG 998
ATOM 998 CD PRO 129 110 .173 19, .542 18. .926 1. .00 41 .11 1SG 999
ATOM 999 CB PRO 129 111, .364 19, .359 16. .833 1, .00 41 .11 1SG1000
ATOM 1000 CG PRO 129 110, .714 20, .394 17, .769 1. .00 41 .11 1SG1001
ATOM 1001 C PRO 129 113 .245 18, .127 18, .009 1. .00 41 .11 1SG1002
ATOM 1002 O PRO 129 113 .697 18, .633 19, .033 1. .00 41 .11 1SG1003
ATOM 1003 N THR 130 114, .016 17. .481 17. .117 1, .00 43 .89 1SG1004
ATOM 1004 CA THR 130 115, .424 17. .446 17, .365 1. .00 43. .89 1SG1005
ATOM 1005 CB THR 130 115, .869 16. .209 18. .097 1. .00 43. .89 1SG1006
ATOM 1006 OGl THR 130 117 .271 16 .233 18 .318 1. .00 43 .89 1SG1007
ATOM 1007 CG2 THR 130 115 .440 14 .966 17 .316 1, .00 43 .89 1SG1008
ATOM 1008 C THR 130 116 .164 17, .621 16. .078 1, .00 43 .89 1SG1009
ATOM 1009 O THR 130 115 .668 17, .285 15. .004 1, .00 43 .89 1SG1010
ATOM 1010 N LEU 131 117 .374 18 .212 16. .173 1, .00 44 .88 1SG1011
ATOM 1011 CA LEU 131 118, .210 18 .494 15 .042 1, .00 44 .88 1SG1012
ATOM 1012 CB LEU 131 118, .213 19, .981 14, .658 1. .00 44 .88 1SG1013
ATOM 1013 CG LEU 131 119, .350 20, .333 13, .686 1, .00 44 .88 1SG1014
ATOM 1014 CD2 LEU 131 119 .331 21, .824 13, .313 1, .00 44 .88 1SG1015
ATOM 1015 CDl LEU 131 119 .331 19 .411 12 .465 1, .00 44 .88 1SG1016
ATOM 1016 C LEU 131 119. .630 18, .139 15, .366 1, .00 44 .88 1SG1017
ATOM 1017 O LEU 131 120. .091 18, .333 16, .488 1, .00 44 .88 1SG1018
ATOM 1018 N LYS 132 120. .362 17, .598 14, .370 1, .00 43 .76 1SG1019
ATOM 1019 CA LYS 132 121. .750 17, .277 14. .556 1. .00 43 .76 1SG1020
ATOM 1020 CB LYS 132 121. .994 15. .801 14, .915 1, .00 43 .76 1SG1021
ATOM 1021 CG LYS 132 121 .420 15 .401 16 .276 1, .00 43 .76 1SG1022
ATOM 1022 CD LYS 132 121 .368 13 .887 16 .497 1 .00 43 .76 1SG1023
ATOM 1023 CE LYS 132 120 .797 13 .484 17 .859 1 .00 43 .76 1SG1024
ATOM 1024 NZ LYS 132 120. .785 12. .009 17 .984 1 .00 43 .76 1SG1025
ATOM 1025 C LYS 132 122. .430 17. .529 13, .246 1, .00 43 .76 1SG1026
ATOM 1026 O LYS 132 121. .777 17, .531 12 .203 1, .00 43 .76 1SG1027
ATOM 1027 N LEU 133 123 .761 17, .772 13 .244 1, .00 45 .25 1SG1028
ATOM 1028 CA LEU 133 124, .349 17, .960 11 .950 1, .00 45 .25 1SG1029
ATOM 1029 CB LEU 133 125. .215 19. .227 11, .759 1. .00 45. .25 1SG1030
ATOM 1030 CG LEU 133 126, .576 19. .319 12, .468 1, .00 45. .25 1SG1031
ATOM 1031 CD2 LEU 133 127, .067 20, .773 12, .414 1, .00 45. .25 1SG1032
ATOM 1032 CDl LEU 133 127, .618 18, .347 11, .891 1. .00 45 .25 1SG1033
ATOM 1033 C LEU 133 125. .089 16. .721 11. .570 1. .00 45, .25 1SG1034
ATOM 1034 O LEU 133 125. .946 16. .226 12. .302 1. .00 45, .25 1SG1035
ATOM 1035 N GLN 134 124. .683 16. .140 10. .422 1. .00 44 , .38 1SG1036
ATOM 1036 CA GLN 134 125 .255 14. .925 9 .925 1, .00 44 .38 1SG1037
ATOM 1037 CB GLN 134 124. .450 14. .303 8, .770 1, .00 44 .38 1SG1038
ATOM 1038 CG GLN 134 123, .027 13. .876 9, .137 1, .00 44, .38 1SG1039
ATOM 1039 CD GLN 134 122, .114 15. .086 9. .000 1. .00 44, .38 1SG1040
ATOM 1040 OEl GLN 134 122, .139 16, .009 9. .812 1, .00 44, .38 1SG1041
ATOM 1041 NE2 GLN 134 121. .271 15. .081 7 .933 1, .00 44, .38 1SG1042
ATOM 1042 C GLN 134 126, .639 15. .144 9, .394 1. .00 44. .38 1SG1043
ATOM 1043 O GLN 134 127, .548 14. .373 9, .700 1. .00 44. .38 1SG1044
ATOM 1044 N ASP 135 126. .843 16. .200 8, .575 1. .00 44. .30 1SG1045
ATOM 1045 CA ASP 135 128. .135 16. .347 7. .959 1, .00 44. .30 1SG1046
ATOM 1046 CB ASP 135 128. .188 15. .766 6. .534 1. .00 44. .30 1SG1047
ATOM 1047 CG ASP 135 129. .643 15. .648 6. .103 1. ,00 44. .30 1SG1048
ATOM 1048 ODl ASP 135 130. .536 15. ,698 6. .991 1. .00 44. .30 1SG1049
ATOM 1049 OD2 ASP 135 129. .881 15. ,492 4 , .875 1. .00 44. .30 1SG1050
ATOM 1050 C ASP 135 128. .497 17. 798 7. ,855 1. .00 44. .30 1SG1051
ATOM 1051 O ASP 135 127. .629 18. ,669 7. .836 1. .00 44. .30 1SG1052 ATOM 1052 N CYS 136 129,.818 18..084 7..797 1..00 44..47 1SG1053
ATOM 1053 CA CYS 136 130, .299 19. .431 7, .684 1. .00 44. .47 1SG1054
ATOM 1054 CB CYS 136 130, .639 20. .044 9, .049 1. .00 44. .47 1SG1055
ATOM 1055 SG CYS 136 131. .434 21. .666 8. .921 1. .00 44. .47 1SG1056
ATOM 1056 C CYS 136 131. .562 19. .425 6. .874 1. .00 44. .47 1SG1057
ATOM 1057 O CYS 136 132 .337 18, .470 6. .923 1. .00 44. .47 1SG1058
ATOM 1058 N TYR 137 131 .782 20, .493 6, .072 1, .00 42. .33 1SG1059
ATOM 1059 CA TYR 137 132. .979 20, .602 5, .284 1. .00 42. .33 1SG1060
ATOM 1060 CB TYR 137 132, .796 20, .035 3, .864 1. .00 42. .33 1SG1061
ATOM 1061 CG TYR 137 134 .066 20, .184 3 .100 1, .00 42, .33 1SG1062
ATOM 1062 CDl TYR 137 135 .123 19, .330 3, .321 1. .00 42, .33 1SG1063
ATOM 1063 CD2 TYR 137 134, .192 21, .165 2, .144 1. .00 42. .33 1SG1064
ATOM 1064 CE1 TYR 137 136, .291 19. .464 2, .609 1. .00 42. .33 1SG1065
ATOM 1065 CE2 TYR 137 135, .358 21. .303 1. .428 1. .00 42. .33 1SG1066
ATOM 1066 CZ TYR 137 136 .411 20. .453 1, .662 1, .00 42, .33 1SG1067
ATOM 1067 OH TYR 137 137 .609 20. .591 0, .930 1. .00 42, .33 1SG1068
ATOM 1068 C TYR 137 133, .326 22, .059 5. .162 1, .00 42, .33 1SG1069
ATOM 1069 O TYR 137 132, .446 22 , .901 4, .998 1. .00 42, .33 1SG1070
ATOM 1070 N ALA 138 134 .633 22, .388 5 .219 1 .00 40, .66 1SG1071
ATOM 1071 CA ALA 138 135 .083 23 , .748 5, .092 1. .00 40, .66 1SG1072
ATOM 1072 CB ALA 138 135 .892 24, .236 6, .307 1. .00 40, .66 1SG1073
ATOM 1073 C ALA 138 136, .017 23. .766 3, .919 1. .00 40, .66 1SG1074
ATOM 1074 O ALA 138 136, .489 22. .715 3 , .492 1. .00 40. .66 1SG1075
ATOM 1075 N GLN 139 136 .269 24. .954 3 .328 1 .00 38. .95 1SG1076
ATOM 1076 CA GLN 139 137 .187 25, .015 2, .222 1. .00 38. .95 1SG1077
ATOM 1077 CB GLN 139 136, .520 24. .754 0, .860 1. .00 38. .95 1SG1078
ATOM 1078 CG GLN 139 137, .495 24. .811 -0, .318 1. .00 38. .95 1SG1079
ATOM 1079 CD GLN 139 136 .708 24. .538 -1 .592 1 .00 38 .95 1SG1080
ATOM 1080 OEl GLN 139 137 .265 24 , .521 -2 .689 1 .00 38. .95 1SG1081
ATOM 1081 NE2 GLN 139 135 .374 24, .320 -1, .446 1. .00 38, .95 1SG1082
ATOM 1082 C GLN 139 137, .791 26. .387 2, .167 1, .00 38, .95 1SG1083
ATOM 1083 O GLN 139 137, .084 27. .389 2, .238 1, .00 38, .95 1SG1084
ATOM 1084 N LEU 140 139 .133 26, .458 2 .024 1 .00 37 .91 1SG1085
ATOM 1085 CA LEU 140 139, .849 27. .704 1, .950 1. .00 37, .91 1SG1086
ATOM 1086 CB LEU 140 140. .981 27. .803 2, .992 1. .00 37, .91 1SG1087
ATOM 1087 CG LEU 140 141, .991 28. .937 2, .718 1. .00 37. .91 1SG1088
ATOM 1088 CD2 LEU 140 141 .276 30, .196 2 .210 1. .00 37. .91 1SG1089
ATOM 1089 CDl LEU 140 143 .090 28, .498 1 .734 1. .00 37. .91 1SG1090
ATOM 1090 C LEU 140 140, .459 27. .855 0, .589 1. .00 37. .91 1SG1091
ATOM 1091 O LEU 140 141, .169 26. .970 0, .113 1. .00 37. .91 1SG1092
ATOM 1092 N SER 141 140, .150 28. .986 -0. .083 1. .00 35. .23 1SG1093
ATOM 1093 CA SER 141 140 .674 29. .300 -1, .384 1. .00 35, .23 1SG1094
ATOM 1094 CB SER 141 139. .901 30. .437 -2 , .072 1. .00 35. .23 1SG1095
ATOM 1095 OG SER 141 138. .559 30. .039 -2. .312 1. .00 35. .23 1SG1096
ATOM 1096 C SER 141 142. .115 29. .722 -1. .325 1. .00 35. .23 1SG1097
ATOM 1097 O SER 141 142. .986 29. .051 -1. .879 1, .00 35. .23 1SG1098
ATOM 1098 N HIS 142 142. .410 30. .856 -0, .647 1. .00 34. .90 1SG1099
ATOM 1099 CA HIS 142 143. .761 31. .352 -0. .667 1. .00 34. .90 1SG1100
ATOM 1100 NDl HIS 142 145, .977 33. .879 -1. .172 1. .00 34. .90 1SG1101
ATOM 1101 CG HIS 142 145, .424 32. ,841 -1. .890 1. .00 34. .90 1SG1102
ATOM 1102 CB HIS 142 143, .996 32. .400 -1. .770 1. .00 34. .90 1SG1103
ATOM 1103 NE2 HIS 142 147, .592 33. .075 -2. .472 1. .00 34. .90 1SG1104
ATOM 1104 CD2 HIS 142 146, .425 32. .362 -2. .679 1. .00 34. ,90 1SG1105
ATOM 1105 CE1 HIS 142 147. .274 33. .975 -1. .560 1. .00 34. ,90 1SG1106
ATOM 1106 C HIS 142 144. .087 32. .003 0. .643 1. .00 34. .90 1SG1107
ATOM 1107 O HIS 142 143. .200 32. .331 1. .429 1. .00 34. .90 1SG1108
ATOM 1108 N ALA 143 145. .400 32. .185 0. .912 1. .00 35. .46 1SG1109 H H H H H H H H H H CN CN CN CN C CN C CN C C r ro ro O M ro ro n ' ^ ^ ^ ^ ^ ^ ^ ^ ^ in i i i ui i i i i vo vD o vo io vo vo H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H
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ATOM 1337 CB GLU 172 140.117 20.754 11.887 1,.00 44.39 1SG1338
ATOM 1338 CG GLU 172 139 .724 19 .788 13 .008 1, .00 44, .39 1SG1339
ATOM 1339 CD GLU 172 140 .992 19 .116 13 .515 1 .00 44 .39 1SG1340
ATOM 1340 OEl GLU 172 142 .090 19 .460 13 .001 1 .00 44 .39 1SG1341
ATOM 1341 OE2 GLU 172 140 .880 18 .252 14 .425 1 .00 44 .39 1SG1342
ATOM 1342 C GLU 172 138 .276 22 .289 12 .377 1 .00 44 .39 1SG1343
ATOM 1343 O GLU 172 137 .303 21 .846 12 .965 1 .00 44 .39 1SG1344
ATOM 1344 N MET 173 138 .782 23 .477 12 .731 1 .00 49 .20 1SG1345
ATOM 1345 CA MET 173 138 .170 24 .168 13 .832 1 .00 49 .20 1SG1346
ATOM 1346 CB MET 173 138 .912 25 .467 14 .185 1 .00 49 .20 1SG1347
ATOM 1347 CG MET 173 140 .344 25 .230 14 .667 1 .00 49 .20 1SG1348
ATOM 1348 SD MET 173 141 .257 26 .743 15 .095 1 .00 49 .20 1SG1349
ATOM 1349 CE MET 173 142. .838 25, .891 15 .362 1, .00 49 .20 1SG1350
ATOM 1350 C MET 173 136 .762 24 .539 13 .484 1 .00 49 .20 1SG1351
ATOM 1351 O MET 173 135 .848 24 .361 14 .287 1 .00 49 .20 1SG1352
ATOM 1352 N LEU 174 136 .538 25 .046 12 .260 1 .00 52 .40 1SG1353
ATOM 1353 CA LEU 174 135, .225 25 .506 11 .912 1 .00 52 .40 1SG1354
ATOM 1354 CB LEU 174 135 .130 26, .139 10 .511 1, .00 52 .40 1SG1355
ATOM 1355 CG LEU 174 135 .663 27 .584 10 .437 1, .00 52 .40 1SG1356
ATOM 1356 CD2 LEU 174 135 .372 28 .208 9 .062 1 .00 52 .40 1SG1357
ATOM 1357 CDl LEU 174 137 .143 27 .680 10 .830 1 .00 52 .40 1SG1358
ATOM 1358 C LEU 174 134 , .211 24. .403 11, .987 1. .00 52. .40 1SG1359
ATOM 1359 0 LEU 174 133, .147 24, .599 12 .570 1, .00 52 .40 1SG1360
ATOM 1360 N CYS 175 134 .490 23 .213 11 .421 1. .00 54 .62 1SG1361
ATOM 1361 CA CYS 175 133 .472 22 .195 11 .441 1 .00 54 .62 1SG1362
ATOM 1362 CB CYS 175 133 .800 20 .954 10 .589 1. .00 54 .62 1SG1363
ATOM 1363 SG CYS 175 133, .411 21, .211 8, .837 1, .00 54 .62 1SG1364
ATOM 1364 C CYS 175 133, .140 21, .775 12 .843 1. .00 54 .62 1SG1365
ATOM 1365 0 CYS 175 131 .962 21 .651 13 .163 1 .00 54 .62 1SG1366
ATOM 1366 N PRO 176 134, .087 21, .501 13, .694 1, .00 53 .35 1SG1367
ATOM 1367 CA PRO 176 133 .678 21 .264 15 .043 1, .00 53 .35 1SG1368
ATOM 1368 CD PRO 176 134, .975 20, .414 13, .316 1, .00 53. .35 1SG1369
ATOM 1369 CB PRO 176 134, .891 20, .668 15 .740 1 .00 53 .35 1SG1370
ATOM 1370 CG PRO 176 135. .446 19, .758 14, .630 1, .00 53 .35 1SG1371
ATOM 1371 C PRO 176 132. .947 22, .361 15, .742 1, .00 53 .35 1SG1372
ATOM 1372 0 PRO 176 132. .104 22, .043 16 .578 1, .00 53 .35 1SG1373
ATOM 1373 N ILE 177 133. .223 23, .643 15, .450 1, .00 48. .32 1SG1374
ATOM 1374 CA ILE 177 132. .419 24. .647 16, .079 1. .00 48 .32 1SG1375
ATOM 1375 CB ILE 177 132. .925 26. .039 15, .807 1. .00 48. .32 1SG1376
ATOM 1376 CG2 ILE 177 131, .741 27. .011 15, .845 1, .00 48, .32 1SG1377
ATOM 1377 CGI ILE 177 134, .063 26. .402 16. .781 1. .00 48. .32 1SG1378
ATOM 1378 CDl ILE 177 135. ,301 25. .517 16. .702 1. .00 48, .32 1SG1379
ATOM 1379 C ILE 177 131. .001 24. .509 15. .600 1. .00 48. .32 1SG1380
ATOM 1380 0 ILE 177 130. .069 24. .488 16. .402 1. .00 48. .32 1SG1381
ATOM 1381 N ILE 178 130. .796 24. .355 14. .279 1. .00 43. .43 1SG1382
ATOM 1382 CA ILE 178 129. .466 24. .290 13. .733 1. .00 43. .43 1SG1383
ATOM 1383 CB ILE 178 129. .451 24. .238 12. .223 1. .00 43. .43 1SG1384
ATOM 1384 CG2 ILE 178 129. .933 22. ,852 11. .765 1. ,00 43. .43 1SG1385
ATOM 1385 CGI ILE 178 128. .071 24. ,634 11. .663 1. .00 43. .43 1SG1386
ATOM 1386 CDl ILE 178 126. .927 23. .695 12. .039 1. .00 43. .43 1SG1387
ATOM 1387 C ILE 178 128. ,736 23. .100 14. .287 1. .00 43. .43 1SG1388
ATOM 1388 O ILE 178 127. .570 23. 205 14. .662 1. 00 43. .43 1SG1389
ATOM 1389 N ALA 179 129. ,399 21. 932 14. .373 1. .00 36. .26 1SG1390
ATOM 1390 CA ALA 179 128. ,725 20. .756 14. ,839 1. .00 36. .26 1SG1391
ATOM 1391 CB ALA 179 129. 629 19. .511 14. ,840 1. ,00 36. .26 1SG1392
ATOM 1392 C ALA 179 128. 263 20. ,980 16. ,243 1. .00 36. .26 1SG1393
ATOM 1393 O ALA 179 127. 144 20. 612 16. 598 1. 00 36. 26 1SG1394 ATOM 1394 N SER 180 129..119 21..598 17..078 1..00 32..13 1SG1395
ATOM 1395 CA SER 180 128. .798 21. .797 18. .463 1. .00 32. .13 1SG1396
ATOM 1396 CB SER 180 129 .968 22, .380 19 .276 1 .00 32. .13 1SG1397
ATOM 1397 OG SER 180 130 .255 23, .704 18 .852 1, .00 32. .13 1SG1398
ATOM 1398 C SER 180 127, .635 22, .730 18 .611 1. .00 32, .13 1SG1399
ATOM 1399 O SER 180 126, .749 22, .488 19 .429 1, .00 32, .13 1SG1400
ATOM 1400 N GLU 181 127, .592 23, .819 17 .818 1, .00 30, .33 1SG1401
ATOM 1401 CA GLU 181 126, .526 24, .775 17 .962 1, .00 30, .33 1SG1402
ATOM 1402 CB GLU 181 126, .605 26, .024 17 .066 1, .00 30, .33 1SG1403
ATOM 1403 CG GLU 181 127, .524 27. .126 17 .590 1, .00 30. .33 1SG1404
ATOM 1404 CD GLU 181 128. .898 26. .887 17 .008 1, .00 30. .33 1SG1405
ATOM 1405 OEl GLU 181 129 .007 26. .921 15 .753 1 .00 30, .33 1SG1406
ATOM 1406 OE2 GLU 181 129, .850 26. .657 17 .800 1, .00 30. .33 1SG1407
ATOM 1407 C GLU 181 125, .222 24, .135 17 .637 1, .00 30. .33 1SG1408
ATOM 1408 O GLU 181 124, .190 24, .533 18 .174 1, .00 30. .33 1SG1409
ATOM 1409 N VAL 182 125, .225 23, .143 16 .732 1, .00 28. .74 1SG1410
ATOM 1410 CA VAL 182 123, .993 22. .524 16 .342 1, .00 28, .74 1SG1411
ATOM 1411 CB VAL 182 124, .194 21. .368 15. .408 1, .00 28, .74 1SG1412
ATOM 1412 CGI VAL 182 122, .830 20. .707 15. .147 1, .00 28, .74 1SG1413
ATOM 1413 CG2 VAL 182 124, .894 21. .882 14, .139 1. .00 28, .74 1SG1414
ATOM 1414 C VAL 182 123 .348 21. .995 17 .577 1 .00 28 .74 1SG1415
ATOM 1415 O VAL 182 122 .138 22. .123 17 .760 1 .00 28. .74 1SG1416
ATOM 1416 N LYS 183 124, .153 21. .417 18 .481 1, .00 29, .98 1SG1417
ATOM 1417 CA LYS 183 123, .603 20. .893 19 .694 1, .00 29, .98 1SG1418
ATOM 1418 CB LYS 183 124, .683 20, .346 20 .643 1, .00 29, .98 1SG1419
ATOM 1419 CG LYS 183 125, .423 19, .131 20 .080 1, .00 29, .98 1SG1420
ATOM 1420 CD LYS 183 126, .714 18. .791 20, .828 1, .00 29, .98 1SG1421
ATOM 1421 CE LYS 183 127, .445 17. .575 20, .257 1, .00 29. .98 1SG1422
ATOM 1422 NZ LYS 183 128, .692 17. .327 21, .015 1, .00 29. .98 1SG1423
ATOM 1423 C LYS 183 122 .921 22. .038 20 .388 1 .00 29, .98 1SG1424
ATOM 1424 O LYS 183 121 .850 21, .874 20 .967 1, .00 29 .98 1SG1425
ATOM 1425 N ALA 184 123, .530 23, .238 20 .343 1, .00 29 .90 1SG1426
ATOM 1426 CA ALA 184 122, .969 24, .427 20 .927 1, .00 29, .90 1SG1427
ATOM 1427 CB ALA 184 123, .886 25. .653 20, .781 1, .00 29, .90 1SG1428
ATOM 1428 C ALA 184 121, .689 24, .738 20 .219 1, .00 29, .90 1SG1429
ATOM 1429 O ALA 184 120, .717 25. .180 20, .829 1, .00 29, .90 1SG1430
ATOM 1430 N LEU 185 121, .667 24. .521 18, .892 1, .00 29, .13 1SG1431
ATOM 1431 CA LEU 185 120, .513 24. .830 18, .102 1. .00 29, .13 1SG1432
ATOM 1432 CB LEU 185 120 .759 24, .547 16 .602 1, .00 29 .13 1SG1433
ATOM 1433 CG LEU 185 119 .693 25, .063 15 .604 1, .00 29, .13 1SG1434
ATOM 1434 CD2 LEU 185 118 .265 24. .599 15, .931 1, .00 29, .13 1SG1435
ATOM 1435 CDl LEU 185 120, .092 24, .697 14, .166 1, .00 29, .13 1SG1436
ATOM 1436 C LEU 185 119, .377 23 , .976 18, .575 1, .00 29, .13 1SG1437
ATOM 1437 O LEU 185 118, .256 24. .460 18, .724 1. .00 29. .13 1SG1438
ATOM 1438 N ASN 186 119, .628 22. .679 18, .835 1. .00 28. .83 1SG1439
ATOM 1439 CA ASN 186 118, .543 21. .815 19, .202 1. .00 28. .83 1SG1440
ATOM 1440 CB ASN 186 118, .903 20. ,313 19, .271 1. .00 28. .83 1SG1441
ATOM 1441 CG ASN 186 119, .905 20, .034 20 .379 1. .00 28,, .83 1SG1442
ATOM 1442 ODl ASN 186 119, .639 20, .242 21, .562 1. .00 28, .83 1SG1443
ATOM 1443 ND2 ASN 186 121, .099 19. .518 19, .983 1. .00 28. .83 1SG1444
ATOM 1444 C ASN 186 117, .952 22. .242 20, .510 1. .00 28. .83 1SG1445
ATOM 1445 O ASN 186 116, .740 22. .165 20, .699 1. .00 28. .83 1SG1446
ATOM 1446 N ALA 187 118. .788 22. .716 21. .449 1. .00 27. .91 1SG1447
ATOM 1447 CA ALA 187 118. .301 23. ,096 22. .745 1. .00 27. .91 1SG1448
ATOM 1448 CB ALA 187 119. .419 23. ,596 23. .676 1. .00 27. ,91 1SG1449
ATOM 1449 C ALA 187 117. .312 24. ,209 22. .589 1. .00 27. .91 1SG1450
ATOM 1450 O ALA 187 116, .301 24. .251 23. .289 1. .00 27. .91 1SG1451 ATOM 1451 N ASN 188 117..590 25..150 21..670 1..00 30,.41 1SG1452
ATOM 1452 CA ASN 188 116. .730 26. .281 21. .467 1. 00 30. ,41 1SG1453
ATOM 1453 CB ASN 188 117. .292 27. .269 20. .430 1. 00 30. ,41 1SG1454
ATOM 1454 CG ASN 188 116. .401 28. .503 20. .417 1. .00 30. .41 1SG1455
ATOM 1455 ODl ASN 188 115. .766 28. .836 21. ,416 1. 00 30. ,41 1SG1456
ATOM 1456 ND2 ASN 188 116. .346 29. .199 19. ,250 1. .00 30. .41 1SG1457
ATOM 1457 C ASN 188 115, .397 25. .821 20. .959 1. ,00 30. .41 1SG1458
ATOM 1458 O ASN 188 114, .353 26. .309 21. .386 1. .00 30. .41 1SG1459
ATOM 1459 N LEU 189 115. .402 24. .850 20. .032 1. .00 35. .18 1SG1460
ATOM 1460 CA LEU 189 114. .211 24. .355 19. .401 1. ,00 35. .18 1SG1461
ATOM 1461 CB LEU 189 114, .504 23. .315 18. .308 1. .00 35. .18 1SG1462
ATOM 1462 CG LEU 189 115. .291 23. .890 17. .117 1. .00 35. .18 1SG1463
ATOM 1463 CD2 LEU 189 114. .626 25. .164 16. .572 1. ,00 35. .18 1SG1464
ATOM 1464 CDl LEU 189 115, .522 22. .825 16. .033 1. ,00 35, .18 1SG1465
ATOM 1465 C LEU 189 113, .329 23, .696 20. .415 1. .00 35. .18 1SG1466
ATOM 1466 O LEU 189 112, .116 23. .632 20. .233 1. .00 35. .18 1SG1467
ATOM 1467 N SER 190 113 , .928 23. .135 21. .478 1. .00 40. .51 1SG1468
ATOM 1468 CA SER 190 113, .230 22. .426 22. .514 1. .00 40, .51 1SG1469
ATOM 1469 CB SER 190 114 , .183 21. .674 23. .457 1. ,00 40. .51 1SG1470
ATOM 1470 OG SER 190 114, .859 20. .647 22. .747 1. .00 40. .51 1SG1471
ATOM 1471 C SER 190 112, .440 23, .386 23, .346 1. .00 40. .51 1SG1472
ATOM 1472 O SER 190 111 .750 22, .981 24, .278 1, .00 40, .51 1SG1473
ATOM 1473 N THR 191 112, .560 24. .690 23, .055 1. .00 46. .15 1SG1474
ATOM 1474 CA THR 191 111, .864 25. .714 23. .776 1. .00 46. .15 1SG1475
ATOM 1475 CB THR 191 112 .319 27. .097 23, .437 1, .00 46, .15 1SG1476
ATOM 1476 OGl THR 191 113. .706 27. .241 23. .699 1. .00 46 , .15 1SG1477
ATOM 1477 CG2 THR 191 111. .525 28. .067 24. .321 1. .00 46, .15 1SG1478
ATOM 1478 C THR 191 110 .403 25, .633 23, .464 1. .00 46, .15 1SG1479
ATOM 1479 O THR 191 109 .573 26 .114 24, .233 1. .00 46 .15 1SG1480
ATOM 1480 N LEU 192 110. .058 25. .056 22. .297 1. .00 49, .20 1SG1481
ATOM 1481 CA LEU 192 108 .701 24, .963 21, .841 1. .00 49, .20 1SG1482
ATOM 1482 CB LEU 192 108 .591 24, .102 20, .565 1. .00 49 .20 1SG1483
ATOM 1483 CG LEU 192 107. .181 23, .992 19, .957 1. .00 49, .20 1SG1484
ATOM 1484 CD2 LEU 192 107 .120 22, .886 18, .887 1. .00 49, .20 1SG1485
ATOM 1485 CDl LEU 192 106 .698 25, .352 19, .429 1. .00 49, .20 1SG1486
ATOM 1486 C LEU 192 107 .883 24 .310 22 .922 1. .00 49 .20 1SG1487
ATOM 1487 O LEU 192 108 .317 23, .340 23, .541 1. .00 49, .20 1SG1488
ATOM 1488 N GLU 193 106 .671 24, .849 23, .201 1. .00 50, .37 1SG1489
ATOM 1489 CA GLU 193 105 .872 24 .311 24 .274 1. .00 50 .37 1SG1490
ATOM 1490 CB GLU 193 104. .760 25, .267 24, .740 1. .00 50. .37 1SG1491
ATOM 1491 CG GLU 193 105 .283 26, .581 25, .324 1. .00 50. .37 1SG1492
ATOM 1492 CD GLU 193 105 .897 26, .302 26, .688 1. .00 50, .37 1SG1493
ATOM 1493 OEl GLU 193 105 .542 25 .260 27 .303 1. .00 50. .37 1SG1494
ATOM 1494 OE2 GLU 193 106. .729 27, .135 27, .133 1. .00 50. .37 1SG1495
ATOM 1495 C GLU 193 105 .193 23, .048 23, .833 1. .00 50, .37 1SG1496
ATOM 1496 O GLU 193 104 .498 23, .041 22 .820 1. .00 50, .37 1SG1497
ATOM 1497 N VAL 194 105. .436 21, .920 24, .538 1. .00 51. .19 1SG1498
ATOM 1498 CA VAL 194 104 .730 20, .699 24, .248 1. .00 51. .19 1SG1499
ATOM 1499 CB VAL 194 105 .460 19, .471 24, .703 1. .00 51. .19 1SG1500
ATOM 1500 CGI VAL 194 104 .604 18, .235 24, .366 1. .00 51, .19 1SG1501
ATOM 1501 CG2 VAL 194 106. .852 19, .469 24, .046 1. .00 51, .19 1SG1502
ATOM 1502 C VAL 194 103 .389 20, .702 24, .912 1. .00 51, .19 1SG1503
ATOM 1503 O VAL 194 102 .345 20, .537 24, .283 1. .00 51, .19 1SG1504
ATOM 1504 N LEU 195 103, .401 20. .904 26, .241 1. .00 52. .09 1SG1505
ATOM 1505 CA LEU 195 102, .173 20. .960 26, .967 1. .00 52. .09 1SG1506
ATOM 1506 CB LEU 195 102 .018 19. .916 28, .092 1. .00 52, .09 1SG1507
ATOM 1507 CG LEU 195 101. .822 18. .480 27. .575 1. ,00 52. ,09 1SG1508 ATOM 1508 CD2 LEU 195 101..286 17.564 28.684 1.00 52.09 1SG1509
ATOM 1509 CDl LEU 195 103. .085 17 .941 26 .893 1 .00 52 .09 1SG1510
ATOM 1510 C LEU 195 102. .149 22 .315 27 .558 1 .00 52 .09 1SG1511
ATOM 1511 O LEU 195 102. .859 22 .607 28 .520 1 .00 52 .09 1SG1512
ATOM 1512 N THR 196 101. .314 23 .184 26 .972 1 .00 56, .02 1SG1513
ATOM 1513 CA THR 196 101. .280 24 .528 27 .436 1 .00 56, .02 1SG1514
ATOM 1514 CB THR 196 101. .043 25 .511 26 .327 1 .00 56, .02 1SG1515
ATOM 1515 OGl THR 196 102. .022 25 .350 25 .310 1 .00 56, .02 1SG1516
ATOM 1516 CG2 THR 196 101. .127 26 .928 26 .917 1 .00 56 .02 1SG1517
ATOM 1517 C THR 196 100. .139 24 .631 28 .389 1 .00 56, .02 1SG1518
ATOM 1518 O THR 196 98. .981 24 .443 28 .018 1, .00 56, .02 1SG1519
ATOM 1519 N LYS 197 100. .456 24 .925 29 .663 1 .00 61, .58 1SG1520
ATOM 1520 CA LYS 197 99, .447 25 .039 30 .671 1 .00 61, .58 1SG1521
ATOM 1521 CB LYS 197 99, .970 24 .774 32 .089 1, .00 61, .58 1SG1522
ATOM 1522 CG LYS 197 98, .863 24 .901 33 .132 1, .00 61 .58 1SG1523
ATOM 1523 CD LYS 197 99, .353 24 .766 34 .570 1 .00 61, .58 1SG1524
ATOM 1524 CE LYS 197 100, .565 23 .856 34, .731 1, .00 61, .58 1SG1525
ATOM 1525 NZ LYS 197 101, .190 24. .093 36 .050 1, .00 61 .58 1SG1526
ATOM 1526 C LYS 197 99, .015 26, .466 30 .685 1, .00 61 .58 1SG1527
ATOM 1527 O LYS 197 99. .774 27, .356 31, .066 1, .00 61, .58 1SG1528
ATOM 1528 N ILE 198 97, .799 26, .730 30 .187 1. .00 67, .27 1SG1529
ATOM 1529 CA ILE 198 97, .261 28, .051 30, .206 1, .00 67 .27 1SG1530
ATOM 1530 CB ILE 198 96, .225 28 .284 29 .145 1 .00 67 .27 1SG1531
ATOM 1531 CG2 ILE 198 96 .945 28 .178 27 .794 1 .00 67 .27 1SG1532
ATOM 1532 CGI ILE 198 95, .016 27 .344 29 .270 1 .00 67 .27 1SG1533
ATOM 1533 CDl ILE 198 93, .926 27 .674 28 .247 1 .00 67 .27 1SG1534
ATOM 1534 C ILE 198 96, .738 28 .416 31 .552 1 .00 67 .27 1SG1535
ATOM 1535 O ILE 198 96, .840 29 .573 31 .961 1, .00 67 .27 1SG1536
ATOM 1536 N ASP 199 96, .116 27 .446 32 .252 1 .00 73 .19 1SG1537
ATOM 1537 CA ASP 199 95, .428 27 .801 33 .452 1 .00 73 .19 1SG1538
ATOM 1538 CB ASP 199 93, .951 27 .967 33 .111 1, .00 73, .19 1SG1539
ATOM 1539 CG ASP 199 93, .539 29, .261 33 .743 1, .00 73, .19 1SG1540
ATOM 1540 ODl ASP 199 93, .649 29 .382 34 .986 1, .00 73 .19 1SG1541
ATOM 1541 OD2 ASP 199 93, .147 30, .170 32, .962 1, .00 73, .19 1SG1542
ATOM 1542 C ASP 199 95, .531 26, .658 34, .420 1, .00 73, .19 1SG1543
ATOM 1543 O ASP 199 96, .328 25, .737 34, .248 1, .00 73, .19 1SG1544
ATOM 1544 N ASN 200 94, .725 26, .708 35, .503 1, .00 73, .49 1SG1545
ATOM 1545 CA ASN 200 94, .690 25, .573 36, .375 1, .00 73, .49 1SG1546
ATOM 1546 CB ASN 200 94, .629 25, .918 37, .869 1, .00 73 , .49 1SG1547
ATOM 1547 CG ASN 200 96, .009 26, .412 38, .300 1. .00 73, .49 1SG1548
ATOM 1548 ODl ASN 200 96, .992 26, .329 37, .562 1. .00 73. .49 1SG1549
ATOM 1549 ND2 ASN 200 96. .093 26, .928 39, .554 1. .00 73. .49 1SG1550
ATOM 1550 C ASN 200 93. .454 24. .818 36, .010 1. .00 73. .49 1SG1551
ATOM 1551 O ASN 200 92. .781 24. .225 36. .853 1. .00 73. .49 1SG1552
ATOM 1552 N TYR 201 93. .163 24. .801 34. .702 1. .00 72. .12 1SG1553
ATOM 1553 CA TYR 201 92. .055 24. .114 34, .118 1. .00 72. .12 1SG1554
ATOM 1554 CB TYR 201 90. .905 25. .034 33, .675 1, .00 72. .12 1SG1555
ATOM 1555 CG TYR 201 90, .092 25. .448 34, .861 1. .00 72. .12 1SG1556
ATOM 1556 CDl TYR 201 90, .443 26, .563 35, .583 1. .00 72. .12 1SG1557
ATOM 1557 CD2 TYR 201 88, .978 24 , .729 35, .250 1. .00 72. .12 1SG1558
ATOM 1558 CE1 TYR 201 89, .700 26. .962 36, .664 1. .00 72. .12 1SG1559
ATOM 1559 CE2 TYR 201 88, .229 25. .126 36. .337 1. .00 72. .12 1SG1560
ATOM 1560 CZ TYR 201 88. .593 26. .249 37. .044 1. .00 72. ,12 1SG1561
ATOM 1561 OH TYR 201 87, .843 26. .681 38. .160 1. .00 72. .12 1SG1562
ATOM 1562 C TYR 201 92. .589 23. .432 32. .897 1. .00 72. .12 1SG1563
ATOM 1563 O TYR 201 92. .951 22. ,256 32. .949 1. .00 72. .12 1SG1564
ATOM 1564 N THR 202 92. .617 24. ,156 31. .758 1. ,00 69. .92 1SG1565 ATOM 1565 CA THR 202 93..033 23..574 30,.506 1..00 69..92 1SG1566
ATOM 1566 CB THR 202 92. .263 24. .071 29. .303 1. .00 69. .92 1SG1567
ATOM 1567 OGl THR 202 92. .483 25. .461 29, .124 1. .00 69. .92 1SG1568
ATOM 1568 CG2 THR 202 90 .760 23 .784 29 .470 1. .00 69 .92 1SG1569
ATOM 1569 C THR 202 94. .461 23. .880 30. .172 1. .00 69. .92 1SG1570
ATOM 1570 O THR 202 95, .100 24. .756 30. .756 1. .00 69. .92 1SG1571
ATOM 1571 N LEU 203 94 .985 23 .101 29 .196 1, .00 70 .42 1SG1572
ATOM 1572 CA LEU 203 96 .291 23. .262 28 .619 1. .00 70. .42 1SG1573
ATOM 1573 CB LEU 203 97, .423 22 .531 29 .368 1. .00 70 .42 1SG1574
ATOM 1574 CG LEU 203 97 .401 20. .994 29. .339 1, .00 70. .42 1SG1575
ATOM 1575 CD2 LEU 203 98 .281 20 .424 30 .466 1, .00 70 .42 1SG1576
ATOM 1576 CDl LEU 203 97 .751 20, .439 27, .947 1. .00 70. .42 1SG1577
ATOM 1577 C LEU 203 96 .187 22 .820 27 .182 1. .00 70 .42 1SG1578
ATOM 1578 O LEU 203 95 .142 22, .327 26, .761 1. .00 70, .42 1SG1579
ATOM 1579 N LEU 204 97, .252 23. .030 26, .381 1. .00 73. .83 1SG1580
ATOM 1580 CA LEU 204 97 .231 22, .756 24, .969 1, .00 73. .83 1SG1581
ATOM 1581 CB LEU 204 97 .756 23 .939 24 .147 1. .00 73 .83 1SG1582
ATOM 1582 CG LEU 204 97 .092 25, .285 24, .478 1, .00 73. .83 1SG1583
ATOM 1583 CD2 LEU 204 97, .414 25, .788 25, .902 1. .00 73, .83 1SG1584
ATOM 1584 CDl LEU 204 95 .593 25, .216 24, .173 1. .00 73, .83 1SG1585
ATOM 1585 C LEU 204 98 .272 21 .724 24 .725 1 .00 73 .83 1SG1586
ATOM 1586 O LEU 204 99, .358 21. .825 25. .293 1. .00 73, .83 1SG1587
ATOM 1587 N ASP 205 97, .981 20, .737 23. .854 1. .00 78, .50 1SG1588
ATOM 1588 CA ASP 205 98 .906 19, .674 23 .564 1. .00 78 .50 1SG1589
ATOM 1589 CB ASP 205 98 .194 18 .313 23 .524 1 .00 78 .50 1SG1590
ATOM 1590 CG ASP 205 99, .241 17. .228 23, .454 1, .00 78 .50 1SG1591
ATOM 1591 ODl ASP 205 99, .902 17. .132 22, .393 1. .00 78, .50 1SG1592
ATOM 1592 OD2 ASP 205 99 .395 16. .479 24 .456 1, .00 78 .50 1SG1593
ATOM 1593 C ASP 205 99 .505 19, .921 22, .208 1. .00 78, .50 1SG1594
ATOM 1594 O ASP 205 98. .929 19, .570 21 .184 1. .00 78 .50 1SG1595
ATOM 1595 N TYR 206 100 .663 20, .598 22, .208 1, .00 83, .32 1SG1596
ATOM 1596 CA TYR 206 101 .517 21, .035 21, .139 1. .00 8 .32 1SG1597
ATOM 1597 CB TYR 206 102 .199 22, .352 21, .512 1, .00 83, .32 1SG1598
ATOM 1598 CG TYR 206 101 .155 23, .401 21, .270 1, .00 83 .32 1SG1599
ATOM 1599 CDl TYR 206 99 .811 23, .174 21, .454 1. .00 83, .32 1SG1600
ATOM 1600 CD2 TYR 206 101. .533 24. .660 20. .910 1. .00 83, .32 1SG1601
ATOM 1601 CE1 TYR 206 98 .874 24. .158 21, .227 1. .00 83, .32 1SG1602
ATOM 1602 CE2 TYR 206 100 .610 25. .653 20, .681 1. .00 83 .32 1SG1603
ATOM 1603 CZ TYR 206 99 .273 25. .406 20. .832 1. .00 83, .32 1SG1604
ATOM 1604 OH TYR 206 98. .329 26. .430 20. .594 1. .00 83, .32 1SG1605
ATOM 1605 C TYR 206 102 .445 19. .972 20. .613 1. .00 83, .32 1SG1606
ATOM 1606 O TYR 206 103 .228 20. .236 19. .702 1, .00 83 .32 1SG1607
ATOM 1607 N SER 207 102. .506 18. .805 21. .280 1. .00 79. .60 1SG1608
ATOM 1608 CA SER 207 103. .429 17. .748 20. .952 1. .00 79. .60 1SG1609
ATOM 1609 CB SER 207 103. .185 16. .458 21. .756 1, .00 79, .60 1SG1610
ATOM 1610 OG SER 207 101 .923 15. .900 21. .423 1. .00 79. .60 1SG1611
ATOM 1611 C SER 207 103. .406 17. .386 19. .498 1. .00 79, .60 1SG1612
ATOM 1612 O SER 207 102. .364 17. .306 18. .852 1. .00 79. .60 1SG1613
ATOM 1613 N LEU 208 104. .619 17. .147 18. .958 1. .00 73. .32 1SG1614
ATOM 1614 CA LEU 208 104. .841 16. .812 17. .584 1. .00 73. .32 1SG1615
ATOM 1615 CB LEU 208 106. .336 16. .982 17. .263 1. .00 73. .32 1SG1616
ATOM 1616 CG LEU 208 106. .670 17. .182 15. .784 1. .00 73. .32 1SG1617
ATOM 1617 CD2 LEU 208 108. .193 17. .199 15. .567 1. .00 73. .32 1SG1618
ATOM 1618 CDl LEU 208 106. .007 18. ,471 15. .270 1. .00 73. .32 1SG1619
ATOM 1619 C LEU 208 104. .409 15. .380 17. .403 1. .00 73. .32 1SG1620
ATOM 1620 O LEU 208 104. .846 14. .491 18. ,131 1. ,00 73. .32 1SG1621
ATOM 1621 N ILE 209 103. .480 15. .146 16. 452 1. 00 63. .81 1SG1622 ATOM 1622 CA ILE 209 102..934 13,.858 16.118 1,.00 63.81 1SG1623
ATOM 1623 CB ILE 209 101. .633 13 .929 15 .366 1. .00 63 .81 1SG1624
ATOM 1624 CG2 ILE 209 101. .926 14, .397 13 .930 1. .00 63, .81 1SG1625
ATOM 1625 CGI ILE 209 100. .913 12. .569 15 .430 1, .00 63 .81 1SG1626
ATOM 1626 CDl ILE 209 100. .445 12. .189 16 .836 1. .00 63 .81 1SG1627
ATOM 1627 C ILE 209 103 .887 13 .029 15 .317 1, .00 63 .81 1SG1628
ATOM 1628 O ILE 209 103 .881 11 .807 15 .441 1, .00 63 .81 1SG1629
ATOM 1629 N SER 210 104 .670 13 .655 14 .411 1, .00 51 .96 1SG1630
ATOM 1630 CA SER 210 105 .566 12 .906 13 .569 1, .00 51 .96 1SG1631
ATOM 1631 CB SER 210 104. .979 12, .612 12 .177 1. .00 51 .96 1SG1632
ATOM 1632 OG SER 210 103. .813 11, .808 12 .290 1, .00 51 .96 1SG1633
ATOM 1633 C SER 210 106. .809 13, .724 13 .372 1, .00 51 .96 1SG1634
ATOM 1634 O SER 210 106, .898 14, .854 13 .848 1. .00 51 .96 1SG1635
ATOM 1635 N SER 211 107, .825 13, .170 12 .676 1. .00 44 .36 1SG1636
ATOM 1636 CA SER 211 109, .052 13, .901 12 .503 1. .00 44, .36 1SG1637
ATOM 1637 CB SER 211 110. .219 13, .029 12 .005 1. .00 44, .36 1SG1638
ATOM 1638 OG SER 211 110. .506 12 , .014 12 .956 1. .00 44, .36 1SG1639
ATOM 1639 C SER 211 108. .815 14 .997 11 .509 1. .00 44 .36 1SG1640
ATOM 1640 O SER 211 107. .902 14 .912 10 .690 1. .00 4 .36 1SG1641
ATOM 1641 N PRO 212 109. .610 16 .038 11 .561 1, .00 41 .26 1SG1642
ATOM 1642 CA PRO 212 109. .417 17 .128 10 .648 1. .00 41 .26 1SG1643
ATOM 1643 CD PRO 212 110. .185 16, .487 12 .820 1, .00 41 .26 1SG1644
ATOM 1644 CB PRO 212 110. .307 18, .260 11 .153 1. .00 41 .26 1SG1645
ATOM 1645 CG PRO 212 110, .368 18, .010 12 .671 1. .00 41 .26 1SG1646
ATOM 1646 C PRO 212 109, .692 16, .698 9 .248 1. .00 41 .26 1SG1647
ATOM 1647 O PRO 212 110. .712 16, .053 9 .004 1. .00 41, .26 1SG1648
ATOM 1648 N GLU 213 108, .807 17, .070 8 .308 1. .00 40, .30 1SG1649
ATOM 1649 CA GLU 213 108. .996 16. .655 6 .954 1. .00 40, .30 1SG1650
ATOM 1650 CB GLU 213 107, .708 16, .147 6 .280 1. .00 40 .30 1SG1651
ATOM 1651 CG GLU 213 106, .556 17, .158 6 .274 1, .00 40 .30 1SG1652
ATOM 1652 CD GLU 213 105, .780 17, .016 7 .577 1, .00 40 .30 1SG1653
ATOM 1653 OEl GLU 213 106, .293 16, .337 8 .506 1. .00 40 .30 1SG1654
ATOM 1654 OE2 GLU 213 104, .657 17, .583 7 .658 1. .00 40 .30 1SG1655
ATOM 1655 C GLU 213 109. .501 17, .819 6 .172 1. .00 40, .30 1SG1656
ATOM 1656 O GLU 213 109. .041 18, .948 6 .331 1. .00 40, .30 1SG1657
ATOM 1657 N ILE 214 110. .488 17. .560 5 .296 1. .00 41, .58 1SG1658
ATOM 1658 CA ILE 214 111. .019 18. .623 4 .503 1. .00 41, .58 1SG1659
ATOM 1659 CB ILE 214 112. .509 18. .708 4. .554 1. .00 41, .58 1SG1660
ATOM 1660 CG2 ILE 214 113. .001 19. .650 3. .443 1. ,00 41. .58 1SG1661
ATOM 1661 CGI ILE 214 112, .892 19. .144 5 .980 1. .00 41 .58 1SG1662
ATOM 1662 CDl ILE 214 114 , .365 18. .989 6 .320 1. .00 41. .58 1SG1663
ATOM 1663 C ILE 214 110. .532 18. .410 3 .115 1. .00 41. .58 1SG1664
ATOM 1664 O ILE 214 110. .577 17. .303 2, .579 1. ,00 41. .58 1SG1665
ATOM 1665 N THR 215 109. .992 19. .491 2, .525 1. ,00 44, .97 1SG1666
ATOM 1666 CA THR 215 109. .355 19. .407 1, .250 1. ,00 44, .97 1SG1667
ATOM 1667 CB THR 215 107. .984 20. .019 1, .310 1. .00 44 , .97 1SG1668
ATOM 1668 OGl THR 215 107. ,321 19. .565 2, .476 1. .00 44. .97 1SG1669
ATOM 1669 CG2 THR 215 107. .156 19. .537 0, .112 1. .00 44. .97 1SG1670
ATOM 1670 C THR 215 110. .174 20. ,223 0. .298 1. .00 44. .97 1SG1671
ATOM 1671 O THR 215 111. .320 20. ,572 0. .578 1. 00 44. ,97 1SG1672
ATOM 1672 N GLU 216 109. ,595 20. ,512 -0, .883 1. ,00 46. .71 1SG1673
ATOM 1673 CA GLU 216 110. ,225 21. .296 -1, .896 1. ,00 46. .71 1SG1674
ATOM 1674 CB GLU 216 109. ,413 21. .333 -3, .202 1. .00 46. .71 1SG1675
ATOM 1675 CG GLU 216 109. ,298 19. .971 -3. .889 1. 00 46. .71 1SG1676
ATOM 1676 CD GLU 216 110. ,683 19. .571 -4. .377 1. 00 46. ,71 1SG1677
ATOM 1677 OEl GLU 216 111. 639 20. .359 -4. .148 1. 00 46. ,71 1SG1678
ATOM 1678 OE2 GLU 216 110. 804 18. 473 -4. .983 1. 00 46. ,71 1SG1679 ATOM 1679 C GLU 216 110,.364 22.709 -1.416 1,.00 46.71 1SG1680
ATOM 1680 O GLU 216 111, .393 23 .339 -1 .654 1 .00 46 .71 1SG1681
ATOM 1681 N ASN 217 109, .333 23 .271 -0 .745 1 .00 49 .53 1SG1682
ATOM 1682 CA ASN 217 109, .505 24 .646 -0 .367 1 .00 49 .53 1SG1683
ATOM 1683 CB ASN 217 108, ,722 25 .607 -1 .277 1, .00 49 .53 1SG1684
ATOM 1684 CG ASN 217 109. .342 25 .547 -2 .666 1, .00 49 .53 1SG1685
ATOM 1685 ODl ASN 217 108. .663 25 .257 -3 .650 1 .00 49 .53 1SG1686
ATOM 1686 ND2 ASN 217 110. .669 25 .830 -2 .753 1 .00 49 .53 1SG1687
ATOM 1687 C ASN 217 109. .035 24 .902 1 .036 1 .00 49 .53 1SG1688
ATOM 1688 O ASN 217 108. .914 26 .060 1 .432 1 .00 49 .53 1SG1689
ATOM 1689 N TYR 218 108 .753 23 .858 1 .837 1 .00 53 .54 1SG1690
ATOM 1690 CA TYR 218 108. .325 24 .131 3 .180 1, .00 53 .54 1SG1691
ATOM 1691 CB TYR 218 106. .806 24 .273 3 .308 1, .00 53 .54 1SG1692
ATOM 1692 CG TYR 218 106, .149 23 .208 2 .496 1 .00 53 .54 1SG1693
ATOM 1693 CDl TYR 218 106, .041 23 .366 1 .133 1 .00 53 .54 1SG1694
ATOM 1694 CD2 TYR 218 105. .625 22 .076 3 .075 1 .00 53 .54 1SG1695
ATOM 1695 CE1 TYR 218 105 .435 22 .409 0 .356 1 .00 53 .54 1SG1696
ATOM 1696 CE2 TYR 218 105. .017 21. .115 2. .302 1, .00 53 .54 1SG1697
ATOM 1697 CZ TYR 218 104. .922 21 .279 0, .942 1, .00 53 .54 1SG1698
ATOM 1698 OH TYR 218 104. .298 20 .293 0 .150 1, .00 53 .54 1SG1699
ATOM 1699 C TYR 218 108, .777 23 .066 4 .124 1, .00 53 .54 1SG1700
ATOM 1700 O TYR 218 108, .947 21 .908 3 .750 1 .00 53 .54 1SG1701
ATOM 1701 N LEU 219 108, .983 23 .453 5 .401 1 .00 54 .85 1SG1702
ATOM 1702 CA LEU 219 109, .325 22 .488 6 .404 1 .00 54 .85 1SG1703
ATOM 1703 CB LEU 219 110. .381 22. .981 7, .406 1, .00 54 .85 1SG1704
ATOM 1704 CG LEU 219 110. .985 21 .919 8, .350 1, .00 54 .85 1SG1705
ATOM 1705 CD2 LEU 219 110. .002 20 .812 8, .749 1, .00 54 .85 1SG1706
ATOM 1706 CDl LEU 219 Ill, .640 22 .595 9, .559 1, .00 54 .85 1SG1707
ATOM 1707 C LEU 219 108, .044 22 .330 7 .160 1 .00 54 .85 1SG1708
ATOM 1708 O LEU 219 107, .541 23 .290 7 .744 1 .00 54 .85 1SG1709
ATOM 1709 N ASP 220 107. .466 21. .115 7. .157 1, .00 54, .02 1SG1710
ATOM 1710 CA ASP 220 106. .188 20, .966 7, .786 1. .00 54 .02 1SG1711
ATOM 1711 CB ASP 220 105. .169 20, .204 6, .916 1, .00 54 .02 1SG1712
ATOM 1712 CG ASP 220 104. .789 21, .121 5, .754 1, .00 54, .02 1SG1713
ATOM 1713 ODl ASP 220 105. .220 22, .306 5, .777 1, .00 54 .02 1SG1714
ATOM 1714 OD2 ASP 220 104. .062 20 .658 4 , .835 1, .00 54 .02 1SG1715
ATOM 1715 C ASP 220 106. .323 20 .292 9 .118 1. .00 54 .02 1SG1716
ATOM 1716 O ASP 220 106. .989 19, .266 9, .258 1. .00 54. .02 1SG1717
ATOM 1717 N LEU 221 105. .683 20, .894 10, .145 1. .00 52. .64 1SG1718
ATOM 1718 CA LEU 221 105. .697 20, .381 11. .486 1. .00 52. .64 1SG1719
ATOM 1719 CB LEU 221 106. .139 21, .433 12, .520 1. .00 52. .64 1SG1720
ATOM 1720 CG LEU 221 107. .540 22, .027 12 , .283 1. .00 52. .64 1SG1721
ATOM 1721 CD2 LEU 221 108. .603 20, .927 12 , .134 1. .00 52, .64 1SG1722
ATOM 1722 CDl LEU 221 107. .890 23. .062 13. .365 1. ,00 52. ,64 1SG1723
ATOM 1723 C LEU 221 104. ,279 20. .033 11. .842 1. .00 52. .64 1SG1724
ATOM 1724 O LEU 221 103. ,385 20. .874 11. .745 1. ,00 52. .64 1SG1725
ATOM 1725 N ASN 222 104. ,032 18. .780 12. .278 1. ,00 48. .59 1SG1726
ATOM 1726 CA ASN 222 102. ,691 18. .401 12. .627 1. ,00 48. .59 1SG1727
ATOM 1727 CB ASN 222 102. .239 17. .084 11. .972 1. .00 48. .59 1SG1728
ATOM 1728 CG ASN 222 101. .953 17. .402 10. .507 1. .00 48. .59 1SG1729
ATOM 1729 ODl ASN 222 102. 501 16. .790 9. .592 1. ,00 48. .59 1SG1730
ATOM 1730 ND2 ASN 222 101. .060 18. .403 10. .280 1. ,00 48. .59 1SG1731
ATOM 1731 C ASN 222 102. ,592 18. ,274 14. ,116 1. ,00 48. .59 1SG1732
ATOM 1732 O ASN 222 103. ,409 17. ,614 14. ,757 1. ,00 48. .59 1SG1733
ATOM 1733 N LEU 223 101. .571 18. .936 14. ,704 1. ,00 46. .26 1SG1734
ATOM 1734 CA LEU 223 101. .396 18. .939 16. .131 1. ,00 46. .26 1SG1735
ATOM 1735 CB LEU 223 101. 564 20. 342 16. 745 1. 00 46. 26 1SG1736 ATOM 1736 CG LEU 223 102.,991 20..908 16..568 1..00 46..26 1SG1737
ATOM 1737 CD2 LEU 223 103. .195 22. .179 17. .408 1. ,00 46. .26 1SG1738
ATOM 1738 CDl LEU 223 103. .344 21. .109 15. ,084 1. .00 46. .26 1SG1739
ATOM 1739 C LEU 223 100. .017 18. .422 16. ,453 1. .00 46. .26 1SG1740
ATOM 1740 O LEU 223 99. .119 18. .444 15. .614 1. .00 46. .26 1SG1741
ATOM 1741 N LYS 224 99. .837 17. .907 17. .689 1. .00 46. .57 1SG1742
ATOM 1742 CA LYS 224 98. .615 17. .287 18. .144 1. .00 46. .57 1SG1743
ATOM 1743 CB LYS 224 98. .811 16. .755 19. .577 1. .00 46. .57 1SG1744
ATOM 1744 CG LYS 224 98. .144 15. .417 19. .915 1. .00 46. .57 1SG1745
ATOM 1745 CD LYS 224 96. .622 15. .350 19. .862 1. .00 46. .57 1SG1746
ATOM 1746 CE LYS 224 96. .105 13. .943 20. .183 1. .00 46. .57 1SG1747
ATOM 1747 NZ LYS 224 96. .653 13. .484 21. .480 1, .00 46. .57 1SG1748
ATOM 1748 C LYS 224 97. .504 18. .313 18. .147 1. .00 46. .57 1SG1749
ATOM 1749 O LYS 224 96, .448 18. .102 17. .552 1. .00 46, .57 1SG1750
ATOM 1750 N GLY 225 97, .733 19, .472 18. .801 1. .00 49, .52 1SG1751
ATOM 1751 CA GLY 225 96. .810 20. .580 18. .799 1. .00 49, .52 1SG1752
ATOM 1752 C GLY 225 95. .467 20. .286 19. .408 1. .00 49, .52 1SG1753
ATOM 1753 O GLY 225 94. .443 20. .440 18. .742 1. .00 49, .52 1SG1754
ATOM 1754 N VAL 226 95. .410 19. .861 20. .685 1. .00 56. .05 1SG1755
ATOM 1755 CA VAL 226 94. .114 19. .676 21. .274 1, .00 56. .05 1SG1756
ATOM 1756 CB VAL 226 93. .745 18. .234 21. .442 1. .00 56 .05 1SG1757
ATOM 1757 CGI VAL 226 92 .339 18. .124 22. .073 1. .00 56 .05 1SG1758
ATOM 1758 CG2 VAL 226 93 .971 17. .524 20. .101 1 .00 56 .05 1SG1759
ATOM 1759 C VAL 226 94, .198 20. .223 22. .662 1. .00 56. .05 1SG1760
ATOM 1760 O VAL 226 95, .220 20, .060 23. .327 1. .00 56. .05 1SG1761
ATOM 1761 N PHE 227 93, .126 20, .885 23. .140 1. .00 63. .23 1SG1762
ATOM 1762 CA PHE 227 93, .109 21, .328 24. .504 1. .00 63 .23 1SG1763
ATOM 1763 CB PHE 227 91, .924 22, .240 24. .870 1, .00 63 .23 1SG1764
ATOM 1764 CG PHE 227 92 .151 23 .650 24, .431 1 .00 63 .23 1SG1765
ATOM 1765 CDl PHE 227 91 .892 24 .053 23 , .145 1 .00 63 .23 1SG1766
ATOM 1766 CD2 PHE 227 92. .633 24, .583 25. .317 1, .00 63. .23 1SG1767
ATOM 1767 CE1 PHE 227 92. .099 25, .362 22. .767 1, .00 63 .23 1SG1768
ATOM 1768 CE2 PHE 227 92. .836 25, .890 24. .941 1 .00 63 .23 1SG1769
ATOM 1769 CZ PHE 227 92. .571 26, .291 23. .659 1 .00 63 .23 1SG1770
ATOM 1770 C PHE 227 92 .947 20, .074 25, .295 1 .00 63 .23 1SG1771
ATOM 1771 O PHE 227 92 .288 19. .133 24, .855 1 .00 63 .23 1SG1772
ATOM 1772 N TYR 228 93 .563 20, .041 26. .487 1 .00 68 .03 1SG1773
ATOM 1773 CA TYR 228 93 .681 18 .851 27, .281 1 .00 68 .03 1SG1774
ATOM 1774 CB TYR 228 95. .173 18, .522 27, .155 1, .00 68. .03 1SG1775
ATOM 1775 CG TYR 228 95. .739 17. .412 27, .941 1, .00 68 .03 1SG1776
ATOM 1776 CDl TYR 228 96. .152 17, .623 29, .234 1 .00 68. .03 1SG1777
ATOM 1777 CD2 TYR 228 95 .915 16, .184 27, .351 1 .00 68, .03 1SG1778
ATOM 1778 CE1 TYR 228 96 .718 16, .601 29, .953 1 .00 68 .03 1SG1779
ATOM 1779 CE2 TYR 228 96 .481 15, .159 28, .069 1 .00 68 .03 1SG1780
ATOM 1780 CZ TYR 228 96 .880 15, .370 29, .369 1 .00 68 .03 1SG1781
ATOM 1781 OH TYR 228 97, .468 14, .331 30. .119 1, .00 68, .03 1SG1782
ATOM 1782 C TYR 228 93, .331 19, .174 28. .710 1, .00 68, .03 1SG1783
ATOM 1783 O TYR 228 93, .718 20, .225 29. .208 1, .00 68, .03 1SG1784
ATOM 1784 N PRO 229 92 .514 18, .371 29. .355 1, .00 64, .45 1SG1785
ATOM 1785 CA PRO 229 92 .292 18, .591 30. .769 1, .00 64, .45 1SG1786
ATOM 1786 CD PRO 229 91 .271 18, .018 28. .683 1 .00 64. .45 1SG1787
ATOM 1787 CB PRO 229 90 .842 18, .213 31. .058 1 .00 64, .45 1SG1788
ATOM 1788 CG PRO 229 90 .151 18 .319 29. .693 1 .00 64 .45 1SG1789
ATOM 1789 C PRO 229 93, .221 17, .799 31. .636 1, .00 64. .45 1SG1790
ATOM 1790 O PRO 229 93, .487 16. .639 31. .318 1, .00 64, .45 1SG1791
ATOM 1791 N LEU 230 93, .697 18. .393 32. .745 1, .00 56, .08 1SG1792
ATOM 1792 CA LEU 230 94, .514 17. .701 33. .697 1, .00 56, .08 1SG1793 ATOM 1793 CB LEU 230 95..164 18..690 34..689 1..00 56..08 1SG1794
ATOM 1794 CG LEU 230 96. ,046 18. ,064 35. .792 1. .00 56. .08 1SG1795
ATOM 1795 CD2 LEU 230 97. .108 17. .128 35. .193 1. .00 56. .08 1SG1796
ATOM 1796 CDl LEU 230 95. .213 17. .385 36. .893 1. .00 56. .08 1SG1797
ATOM 1797 C LEU 230 93. .682 16. .732 34, .479 1, .00 56. .08 1SG1798
ATOM 1798 O LEU 230 94. .052 15. .570 34. .645 1. .00 56. .08 1SG1799
ATOM 1799 N GLU 231 92. ,523 17. .193 34. .993 1. .00 44. .60 1SG1800
ATOM 1800 CA GLU 231 91. .781 16. .350 35. .886 1 .00 44, .60 1SG1801
ATOM 1801 CB GLU 231 90. ,535 16. .994 36. .506 1, .00 44. .60 1SG1802
ATOM 1802 CG GLU 231 89. ,880 16. .054 37. .522 1, .00 44. .60 1SG1803
ATOM 1803 CD GLU 231 88. .609 16. .710 38. .034 1. .00 44. .60 1SG1804
ATOM 1804 OEl GLU 231 87, .653 16. .857 37. .228 1. .00 44. .60 1SG1805
ATOM 1805 OE2 GLU 231 88, .580 17. .079 39, .239 1, .00 44. .60 1SG1806
ATOM 1806 C GLU 231 91, .293 15. .130 35. .191 1. .00 44, .60 1SG1807
ATOM 1807 0 GLU 231 91. .485 14. .022 35. .685 1. .00 44, .60 1SG1808
ATOM 1808 N ASN 232 90, .648 15, .291 34, .022 1. .00 33 .57 1SG1809
ATOM 1809 CA ASN 232 90. .147 14. .120 33, .366 1, .00 33. .57 1SG1810
ATOM 1810 CB ASN 232 88. .614 13, .994 33. .354 1. .00 33, .57 1SG1811
ATOM 1811 CG ASN 232 88. .131 13, .655 34 .752 1 .00 33, .57 1SG1812
ATOM 1812 ODl ASN 232 88. .628 12 .736 35, .402 1 .00 33. .57 1SG1813
ATOM 1813 ND2 ASN 232 87. .126 14, .432 35, .235 1 .00 33, .57 1SG1814
ATOM 1814 C ASN 232 90, .535 14 .192 31, .933 1. .00 33, .57 1SG1815
ATOM 1815 0 ASN 232 90, .517 15, .261 31, .327 1 .00 33 .57 1SG1816
ATOM 1816 N LEU 233 90. .883 13, .032 31. .350 1, .00 29. .07 1SG1817
ATOM 1817 CA LEU 233 91. .258 13, .031 29. .972 1, .00 29, .07 1SG1818
ATOM 1818 CB LEU 233 92. .485 12 .151 29. .673 1, .00 29, .07 1SG1819
ATOM 1819 CG LEU 233 93. .753 1 .551 30, .455 1 .00 29 .07 1SG1820
ATOM 1820 CD2 LEU 233 94. .054 14 .055 30. .333 1. .00 29. .07 1SG1821
ATOM 1821 CDl LEU 233 94. .944 11 .660 30. .065 1 .00 29. .07 1SG1822
ATOM 1822 C LEU 233 90, .108 12 .454 29. .211 1 .00 29, .07 1SG1823
ATOM 1823 0 LEU 233 89 .657 11 .345 29. .496 1 .00 29 .07 1SG1824
ATOM 1824 N THR 234 89. .581 13, .217 28. .233 1, .00 28 , .77 1SG1825
ATOM 1825 CA THR 234 88. .513 12 .722 27. .417 1, .00 28, .77 1SG1826
ATOM 1826 CB THR 234 87, .193 13, .382 27. .684 1, .00 28, .77 1SG1827
ATOM 1827 OGl THR 234 86 .808 13 .181 29. .036 1, .00 28 .77 1SG1828
ATOM 1828 CG2 THR 234 86, .140 1 .787 26. .733 1, .00 28, .77 1SG1829
ATOM 1829 C THR 234 88 .868 13 .036 25. .999 1, .00 28 .77 1SG1830
ATOM 1830 0 THR 234 89, .273 14 .155 25. .686 1 .00 28 .77 1SG1831
ATOM 1831 N ASP 235 88 .725 12 .041 25. .101 1 .00 32 .37 1SG1832
ATOM 1832 CA ASP 235 89, .032 1 .245 23. .715 1, .00 32, .37 1SG1833
ATOM 1833 CB ASP 235 89 .237 10 .938 22. .927 1, .00 32, .37 1SG1834
ATOM 1834 CG ASP 235 90 .532 10 .287 23, .392 1 .00 32, .37 1SG1835
ATOM 1835 ODl ASP 235 91. .329 10 .977 24. .083 1. .00 32. .37 1SG1836
ATOM 1836 OD2 ASP 235 90. .745 9, .090 23. .058 1, .00 32. .37 1SG1837
ATOM 1837 C ASP 235 87. .885 12 .969 23, .080 1, .00 32. .37 1SG1838
ATOM 1838 0 ASP 235 86 .742 12 .871 23. .522 1 .00 32 .37 1SG1839
ATOM 1839 N PRO 236 88. .194 13 .715 22. .052 1, .00 37. .68 1SG1840
ATOM 1840 CA PRO 236 87. .173 14, .438 21. .337 1, .00 37, .68 1SG1841
ATOM 1841 CD PRO 236 89, .463 14 .426 22. .042 1. .00 37, .68 1SG1842
ATOM 1842 CB PRO 236 87 .901 15 .519 20, .542 1, .00 37, .68 1SG1843
ATOM 1843 CG PRO 236 89, .180 15, .772 21. .356 1, .00 37. .68 1SG1844
ATOM 1844 C PRO 236 86 .367 13 .519 20. .473 1. .00 37. .68 1SGΪ845
ATOM 1845 0 PRO 236 86 .898 12 .516 20. .002 1, .00 37. .68 1SG1846
ATOM 1846 N PRO 237 85 .127 13 .848 20. .250 1, .00 42 .47 1SG1847
ATOM 1847 CA PRO 237 84, .246 13, .030 19. .460 1. .00 42. .47 1SG1848
ATOM 1848 CD PRO 23-7 84, .397 14 .699 21. .171 1. .00 42. .47 1SG1849
ATOM 1849 CB PRO 237 82, .824 13, .488 19. .794 1. .00 42. .47 1SG1850
:ιo ATOM 1850 CG PRO 237 83..004 14.824 20,.537 1..00 42,.47 1SG1851
ATOM 1851 C PRO 237 84. .565 13 .053 17, .998 1. .00 42, .47 1SG1852
ATOM 1852 O PRO 237 83. .939 12 .307 17, .249 1. .00 42, .47 1SG1853
ATOM 1853 N PHE 238 85. .499 13 .903 17, .551 1. .00 44, .88 1SG1854
ATOM 1854 CA PHE 238 85. .754 13 .992 16, .143 1. .00 44, .88 1SG1855
ATOM 1855 CB PHE 238 85. .209 15 .295 15 .551 1. .00 44, .88 1SG1856
ATOM 1856 CG PHE 238 85. .609 16 .340 16 .528 1. .00 44, .88 1SG1857
ATOM 1857 CDl PHE 238 86. .884 16 .826 16, .576 1. .00 44 .88 1SG1858
ATOM 1858 CD2 PHE 238 84. .702 16 .810 17 .443 1. .00 44 .88 1SG1859
ATOM 1859 CE1 PHE 238 87. .232 17 .782 17, .500 1, .00 44 .88 1SG1860
ATOM 1860 CE2 PHE 238 85. .046 17 .766 18, .367 1. .00 44 .88 1SG1861
ATOM 1861 CZ PHE 238 86. .319 18 .263 18, .401 1, .00 44 .88 1SG1862
ATOM 1862 C PHE 238 87. .223 13 .905 15, .862 1. .00 44 .88 1SG1863
ATOM 1863 O PHE 238 88. .038 13 .767 16, .770 1. .00 44 .88 1SG1864
ATOM 1864 N SER 239 87. .580 13 .939 14 .559 1. .00 45 .43 1SG1865
ATOM 1865 CA SER 239 88. .952 13 .858 14 .142 1. .00 45 .43 1SG1866
ATOM 1866 CB SER 239 89. .232 12 .714 13 .152 1, .00 45 .43 1SG1867
ATOM 1867 OG SER 239 90. .607 12 .707 12 .794 1, .00 45 .43 1SG1868
ATOM 1868 C SER 239 89. .282 15 .138 13 .436 1. .00 45 .43 1SG1869
ATOM 1869 O SER 239 88. .408 15 .811 12 .894 1. .00 45 .43 1SG1870
ATOM 1870 N PRO 240 90. .542 15 .493 13 .450 1, .00 45 .68 1SG1871
ATOM 1871 CA PRO 240 90. .967 16 .710 12 .809 1. .00 45 .68 1SG1872
ATOM 1872 CD PRO 240 91. .409 15 .139 14 .558 1. .00 45 .68 1SG1873
ATOM 1873 CB PRO 240 92. .341 17 .054 13 .395 1. .00 45 .68 1SG1874
ATOM 1874 CG PRO 240 92. .743 15 .809 14 .207 1. .00 45 .68 1SG1875
ATOM 1875 C PRO 240 90. .920 16 .574 11 .323 1. .00 45 .68 1SG1876
ATOM 1876 O PRO 240 91. .071 15 .464 10 .818 1. .00 45 .68 1SG1877
ATOM 1877 N VAL 241 90. .692 17 .688 10 .602 1. .00 43 .92 1SG1878
ATOM 1878 CA VAL 241 90. .578 17 .621 9, .175 1, .00 43 .92 1SG1879
ATOM 1879 CB VAL 241 89. .674 18 .677 8 .613 1. .00 43 .92 1SG1880
ATOM 1880 CGI VAL 241 89. .753 18 .668 7, .078 1. .00 43 .92 1SG1881
ATOM 1881 CG2 VAL 241 88. .261 18 .378 9, .145 1, .00 43 .92 1SG1882
ATOM 1882 C VAL 241 91. .937 17 .721 8 .560 1. .00 43 .92 1SG1883
ATOM 1883 O VAL 241 92. .881 18 .207 9, .178 1, .00 43 .92 1SG1884
ATOM 1884 N PRO 242 92. .087 17 .186 7, .376 1. .00 43 .60 1SG1885
ATOM 1885 CA PRO 242 93. .347 17 .334 6 .715 1. .00 43 .60 1SG1886
ATOM 1886 CD PRO 242 91. .416 15 .952 6, .999 1. .00 43 .60 1SG1887
ATOM 1887 CB PRO 242 93. .329 16 .357 5 .543 1. .00 43 .60 1SG1888
ATOM 1888 CG PRO 242 92. .384 15 .242 6, .033 1. .00 43 .60 1SG1889
ATOM 1889 C PRO 242 93. .488 18, .766 6, .343 1. .00 43 .60 1SG1890
ATOM 1890 O PRO 242 92. .606 19, .293 5, .664 1. .00 43 .60 1SG1891
ATOM 1891 N PHE 243 94. .591 19, .419 6, .745 1. .00 42, .10 1SG1892
ATOM 1892 CA PHE 243 94. .658 20, .799 6, .398 1. .00 42, .10 1SG1893
ATOM 1893 CB PHE 243 94. .994 21, .712 7, .583 1. .00 42. .10 1SG1894
ATOM 1894 CG PHE 243 93. .847 21, .501 8, .503 1. .00 42, .10 1SG1895
ATOM 1895 CDl PHE 243 92. .606 22, .007 8, .193 1. .00 42, .10 1SG1896
ATOM 1896 CD2 PHE 243 94. .012 20, .794 9, .670 1. .00 42, .10 1SG1897
ATOM 1897 CE1 PHE 243 91. .538 21, .807 9, .035 1. .00 42, .10 1SG1898
ATOM 1898 CE2 PHE 243 92. .948 20, .594 10, .513 1. .00 42, .10 1SG1899
ATOM 1899 CZ PHE 243 91. .709 21, .098 10, .197 1. .00 42, .10 1SG1900
ATOM 1900 C PHE 243 95. ,679 20, .965 5, .334 1. .00 42. .10 1SG1901
ATOM 1901 O PHE 243 96. .882 20, .967 5, .593 1. .00 42. .10 1SG1902
ATOM 1902 N VAL 244 95. ,196 21, .110 4 , .088 1. .00 39. .68 1SG1903
ATOM 1903 CA VAL 244 96. ,086 21, .340 2. .999 1. .00 39. .68 1SG1904
ATOM 1904 CB VAL 244 95. ,858 20, .422 1. .828 1. .00 39. .68 1SG1905
ATOM 1905 CGI VAL 244 94. .395 20, .523 1. .366 1. .00 39. .68 1SG1906
ATOM 1906 CG2 VAL 244 96. ,883 20. .769 0. .736 1. ,00 39. .68 1SG1907 ATOM 1907 C VAL 244 95..864 22..757 2..588 1..00 39..68 1SG1908
ATOM 1908 O VAL 244 94. .796 23. .127 2. .102 1. .00 39. .68 1SG1909
ATOM 1909 N LEU 245 96. .883 23. .604 2. .805 1. .00 39, .09 1SG1910
ATOM 1910 CA LEU 245 96. .745 24. .990 2. .479 1, .00 39 .09 1SG1911
ATOM 1911 CB LEU 245 96. .872 25. .926 3 , .698 1 .00 39 .09 1SG1912
ATOM 1912 CG LEU 245 98. .265 25. .935 4. .360 1. .00 39, .09 1SG1913
ATOM 1913 CD2 LEU 245 98. .737 24, .518 4. .728 1, .00 39, .09 1SG1914
ATOM 1914 CDl LEU 245 98 .296 26 .890 5 .563 1, .00 39 .09 1SG1915
ATOM 1915 C LEU 245 97, .831 25 .347 1, .520 1, .00 39, .09 1SG1916
ATOM 1916 O LEU 245 98, .889 24, .721 1, .482 1. .00 39, .09 1SG1917
ATOM 1917 N PRO 246 97, .567 26 .334 0 .713 1, .00 37 .51 1SG1918
ATOM 1918 CA PRO 246 98, .519 26, .772 -0, .265 1, .00 37, .51 1SG1919
ATOM 1919 CD PRO 246 96, .607 27 .373 1 .046 1, .00 37 .51 1SG1920
ATOM 1920 CB PRO 246 97, .891 28, .001 -0, .914 1, .00 37, .51 1SG1921
ATOM 1921 CG PRO 246 97. .053 28. .601 0. .231 1. .00 37, .51 1SG1922
ATOM 1922 C PRO 246 99, .808 27. .118 0. .409 1, .00 37, .51 1SG1923
ATOM 1923 O PRO 246 99, .802 27 .928 1 .335 1. .00 37 .51 1SG1924
ATOM 1924 N GLU 247 100. .927 26. .535 -0. .056 1. .00 36. .57 1SG1925
ATOM 1925 CA GLU 247 102. .201 26. .868 0. .502 1. .00 36 .57 1SG1926
ATOM 1926 CB GLU 247 103 .294 25 .882 0 .068 1. .00 36 .57 1SG1927
ATOM 1927 CG GLU 247 103. .492 25. .818 -1. .447 1. .00 36. .57 1SG1928
ATOM 1928 CD GLU 247 104. .596 24. .812 -1. .737 1. .00 36 .57 1SG1929
ATOM 1929 OEl GLU 247 105, .681 24. .924 -1, .106 1. .00 36 .57 1SG1930
ATOM 1930 OE2 GLU 247 104, .367 23, .914 -2 , .591 1. .00 36. .57 1SG1931
ATOM 1931 C GLU 247 102. .539 28, .215 -0 .045 1. .00 36 .57 1SG1932
ATOM 1932 O GLU 247 102, .465 28, .435 -1 .252 1 .00 36 .57 1SG1933
ATOM 1933 N ARG 248 102, .931 29, ,162 0, .827 1. .00 35. .82 1SG1934
ATOM 1934 CA ARG 248 103. .208 30, .481 0, .339 1. .00 35 .82 1SG1935
ATOM 1935 CB ARG 248 102. .063 31 .465 0, .647 1, .00 35 .82 1SG1936
ATOM 1936 CG ARG 248 102. .241 32, .859 0, .048 1, .00 35 .82 1SG1937
ATOM 1937 CD ARG 248 100. .947 33, .679 0, .040 1. .00 35, .82 1SG1938
ATOM 1938 NE ARG 248 100. .517 33 .884 1, .452 1, .00 35 .82 1SG1939
ATOM 1939 CZ ARG 248 99, .623 33, .025 2 , .023 1. .00 35, .82 1SG1940
ATOM 1940 NHl ARG 248 99 .138 31 .968 1, .307 1, .00 35 .82 1SG1941
ATOM 1941 NH2 ARG 248 99, .205 33, .226 3 , .307 1, .00 35, .82 1SG1942
ATOM 1942 C ARG 248 104, .453 30, .959 1. .012 1. .00 35, .82 1SG1943
ATOM 1943 O ARG 248 104, .910 30, .356 1. .982 1. .00 35, .82 1SG1944
ATOM 1944 N SER 249 105 .069 32 .035 0. .480 1. .00 34 .09 1SG1945
ATOM 1945 CA SER 249 106. .256 32. .530 1. .113 1. ,00 34. .09 1SG1946
ATOM 1946 CB SER 249 107, .507 32. .393 0. .230 1. .00 34, .09 1SG1947
ATOM 1947 OG SER 249 107 .373 33. .201 -0, .930 1. .00 34, .09 1SG1948
ATOM 1948 C SER 249 106, .074 33. .990 1. .384 1. .00 34, .09 1SG1949
ATOM 1949 O SER 249 107, .042 34. .750 1. ,379 1. .00 34. .09 1SG1950
ATOM 1950 N ASN 250 104, .824 34. .423 1. .634 1. .00 34, .00 1SG1951
ATOM 1951 CA ASN 250 104, .578 35. .804 1. .939 1. ,00 34. .00 1SG1952
ATOM 1952 CB ASN 250 103, .086 36. .172 1. .945 1. .00 34. .00 1SG1953
ATOM 1953 CG ASN 250 102, .582 36. .083 0. .514 1, .00 34, .00 1SG1954
ATOM 1954 ODl ASN 250 103, .296 35. .632 -0. .380 1. ,00 34. .00 1SG1955
ATOM 1955 ND2 ASN 250 101, .314 36, .521 0. .288 1. ,00 34. .00 1SG1956
ATOM 1956 C ASN 250 105 .105 36, .085 3. .308 1. .00 34. .00 1SG1957
ATOM 1957 O ASN 250 105. .709 37, .129 3. .552 1. .00 34. .00 1SG1958
ATOM 1958 N SER 251 104. .879 35. .138 4. .240 1. .00 35. .15 1SG1959
ATOM 1959 CA SER 251 105, .296 35. .313 5. .600 1. .00 35. .15 1SG1960
ATOM 1960 CB SER 251 104, .137 35. .287 6. .611 1. ,00 35. ,15 1SG1961
ATOM 1961 OG SER 251 103, .275 36, .395 6. ,396 1. ,00 35. .15 1SG1962
ATOM 1962 C SER 251 106. .204 34. .177 5. ,940 1. ,00 35. .15 1SG1963
ATOM 1963 O SER 251 106. .326 33. ,214 5. .185 1. 00 35. ,15 1SG1964 in vo t- oo σι θ co c o H vD VD VD iD iD r- H ri CN CN
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P εPε εPPεOεPεPεPεPεPε εPPεdεPε εPPεPεPε εPPεPε εP εP εP εPPεPε εPPεPε εP PεPεPε εPPε εP εP dεPε εP εP εP εP εP εP PεPε εP εP PεPεdεPεPε εP εP H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H HH H H H H H H H H H H H H ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft fi ft ft ft ft ft ft ft ft ft ft ft ft ft ft f^
ATOM 2021 CD GLU 259 85.643 23.,413 11.,213 1.00 37..89 1SG2022
ATOM 2022 OEl GLU 259 85. .415 22. .175 11. .274 1. .00 37. .89 1SG2023
ATOM 2023 OE2 GLU 259 84. ,958 24. .220 10. .530 1. .00 37. .89 1SG2024
ATOM 2024 C GLU 259 88. ,323 22. ,614 15. .256 1. ,00 37. ,89 1SG2025
ATOM 2025 O GLU 259 87. ,814 22. ,934 16. .328 1. 00 37. .89 1SG2026
ATOM 2026 N TYR 260 88. .974 21. .454 15. .069 1. ,00 40. .30 1SG2027
ATOM 2027 CA TYR 260 89. .139 20. .441 16. .068 1. ,00 40. .30 1SG2028
ATOM 2028 CB TYR 260 90. .031 19. .321 15. .484 1. ,00 40. .30 1SG2029
ATOM 2029 CG TYR 260 90. ,377 18. .242 16. ,449 1. . 00 40. .30 1SG2030
ATOM 2030 CDl TYR 260 91. ,312 18. ,456 17. .430 1. .00 40. .30 1SG2031
ATOM 2031 CD2 TYR 260 89. .810 16. .996 16. .339 1. .00 40. .30 1SG2032
ATOM 2032 CE1 TYR 260 91. .647 17. .457 18. .307 1. .00 40. .30 1SG2033
ATOM 2033 CE2 TYR 260 90. .138 15. .990 17. .214 1. .00 40, .30 1SG2034
ATOM 2034 CZ TYR 260 91. .059 16. .224 18. .204 1. .00 40 .30 1SG2035
ATOM 2035 OH TYR 260 91, .414 15. .206 19. .111 1. .00 40, .30 1SG2036
ATOM 2036 C TYR 260 89, .834 21. .097 17. .222 1, .00 40, .30 1SG2037
ATOM 2037 O TYR 260 89. .420 20. .948 18. .372 1. .00 40, .30 1SG2038
ATOM 2038 N PHE 261 90 . .888 21. .887 16, .933 1. .00 39, .48 1SG2039
ATOM 2039 CA PHE 261 91, .629 22 .541 17, .974 1. .00 39 .48 1SG2040
ATOM 2040 CB PHE 261 92, .780 23. .422 17 .449 1, .00 39 .48 1SG2041
ATOM 2041 CG PHE 261 93, .293 24. .278 18, .568 1. .00 39, .48 1SG2042
ATOM 2042 CDl PHE 261 94 , .018 23. .748 19, .613 1. . 00 39, .48 1SG2043
ATOM 2043 CD2 PHE 261 93. .064 25, .637 18 .550 1, .00 39 .48 1SG2044
ATOM 2044 CE1 PHE 261 94. .487 24, .556 20, .625 1. .00 39 .48 1SG2045
ATOM 2045 CE2 PHE 261 93. .531 26, .451 19, .557 1. .00 39 .48 1SG2046
ATOM 2046 CZ PHE 261 94. .243 25, .908 20. .599 1. .00 39. .48 1SG2047
ATOM 2047 C PHE 261 90. .713 23, .426 18 .761 1. .00 39 .48 1SG2048
ATOM 2048 O PHE 261 90. .681 23 .349 19 .987 1. .00 39 .48 1SG2049
ATOM 2049 N PHE 262 89. .930 24, .282 18. .080 1, .00 38 .51 1SG2050
ATOM 2050 CA PHE 262 89. .060 25, .196 18. .769 1. .00 38 .51 1SG2051
ATOM 2051 CB PHE 262 88. .350 26, .205 17, .851 1. .00 38 .51 1SG2052
ATOM 2052 CG PHE 262 89 .322 27 .261 17 .457 1, .00 38 .51 1SG2053
ATOM 2053 CDl PHE 262 89. .666 28, .245 18, .357 1. .00 38 .51 1SG2054
ATOM 2054 CD2 PHE 262 89. .868 27, .286 16, .194 1. .00 38, .51 1SG2055
ATOM 2055 CE1 PHE 262 90, .554 29, .235 18, .011 1. .00 38 .51 1SG2056
ATOM 2056 CE2 PHE 262 90, .756 28 .275 15, .842 1, .00 38 .51 1SG2057
ATOM 2057 CZ PHE 262 91, .098 29, .248 16, .751 1. .00 38 .51 1SG2058
ATOM 2058 C PHE 262 87, .984 24. .473 19, .517 1. .00 38, .51 1SG2059
ATOM 2059 O PHE 262 87, .647 24. .852 20. .637 1. .00 38, .51 1SG2060
ATOM 2060 N LYS 263 87, .391 23 .430 18. .910 1. .00 35, .71 1SG2061
ATOM 2061 CA LYS 263 86, .303 22. .737 19. .539 1. .00 35 .71 1SG2062
ATOM 2062 CB LYS 263 85, .656 21. .663 18, .654 1. .00 35, .71 1SG2063
ATOM 2063 CG LYS 263 84 , .796 22. .255 17. .539 1. ,00 35, .71 1SG2064
ATOM 2064 CD LYS 263 84. .263 21 .209 16. .561 1. .00 35, .71 1SG2065
ATOM 2065 CE LYS 263 83, .061 20. .437 17, .108 1. .00 35, .71 1SG2066
ATOM 2066 NZ LYS 263 82, .591 19. .458 16 , .105 1. .00 35. .71 1SG2067
ATOM 2067 C LYS 263 86, .759 22. .068 20. .793 1. ,00 35. .71 1SG2068
ATOM 2068 O LYS 263 85. .999 21. .979 21. .755 1. .00 35. .71 1SG2069
ATOM 2069 N SER 264 88. .008 21, .571 20. .815 1. .00 32. .27 1SG2070
ATOM 2070 CA SER 264 88. .503 20, .862 21. .961 1. .00 32, .27 1SG2071
ATOM 2071 CB SER 264 89. .979 20, .443 21. .807 1. .00 32. .27 1SG2072
ATOM 2072 OG SER 264 90. .827 21. .583 21. .867 1. .00 32, .27 1SG2073
ATOM 2073 C SER 264 88. .448 21. .770 23. .145 1. .00 32, .27 1SG2074
ATOM 2074 O SER 264 88, .216 - 21, .323 24. .266 1. ,00 32. .27 1SG2075
ATOM 2075 N ALA 265 88. .676 23. .077 22. .925 1. ,00 29. .64 1SG2076
ATOM 2076 CA ALA 265 88. .680 24, .024 24. ,001 1. ,00 29. ,64 1SG2077
ATOM 2077 CB ALA 265 89 .024 25 .451 23, .540 1. .00 29 .64 1SG2078 ATOM 2078 C ALA 265 87..324 24..078 24..630 1..00 29.,64 1SG2079
ATOM 2079 O ALA 265 87. .203 24. .106 25. ,853 1. .00 29. .64 1SG2080
ATOM 2080 N SER 266 86. .261 24. .089 23. .806 1. ,00 28. .46 1SG2081
ATOM 2081 CA SER 266 84. ,929 24. .214 24. .325 1. ,00 28. ,46 1SG2082
ATOM 2082 CB SER 266 83. ,859 24. .300 23. .223 1. ,00 28. ,46 1SG2083
ATOM 2083 OG SER 266 84. .032 25. .485 22. .460 1. .00 28. .46 1SG2084
ATOM 2084 C SER 266 84. .597 23. .026 25. .164 1. .00 28. .46 1SG2085
ATOM 2085 O SER 266 83. .974 23. .160 26. .216 1. .00 28. .46 1SG2086
ATOM 2086 N PHE 267 84. .990 21. .822 24. .708 1. .00 28. .98 1SG2087
ATOM 2087 CA PHE 267 84. .623 20. .644 25. .431 1. .00 28. .98 1SG2088
ATOM 2088 CB PHE 267 84. .905 19. .326 24. .693 1. .00 28. .98 1SG2089
ATOM 2089 CG PHE 267 84, .161 18. .291 25. .466 1, .00 28, .98 1SG2090
ATOM 2090 CDl PHE 267 82, .785 18. .281 25. .438 1. .00 28. .98 1SG2091
ATOM 2091 CD2 PHE 267 84. .819 17, .332 26. .202 1. .00 28. .98 1SG2092
ATOM 2092 CE1 PHE 267 82. .070 17, .340 26. .140 1. .00 28. .98 1SG2093
ATOM 2093 CE2 PHE 267 84. .108 16. .387 26. .905 1. .00 28. .98 1SG2094
ATOM 2094 CZ PHE 267 82. .734 16. .390 26. .877 1. .00 28. .98 1SG2095
ATOM 2095 C PHE 267 85. .321 20. .611 26. .754 1. .00 28. .98 1SG2096
ATOM 2096 O PHE 267 84. .712 20, .259 27. .763 1. .00 28, .98 1SG2097
ATOM 2097 N ALA 268 86, .621 20. .971 26. .784 1. .00 29, .52 1SG2098
ATOM 2098 CA ALA 268 87, .394 20. .910 27, .993 1. .00 29, .52 1SG2099
ATOM 2099 CB ALA 268 88, .864 21, .307 27, .775 1. .00 29, .52 1SG2100
ATOM 2100 C ALA 268 86. .837 21, .844 29, .026 1. .00 29, .52 1SG2101
ATOM 2101 O ALA 268 86. .721 21. .479 30, .194 1. .00 29. .52 1SG2102
ATOM 2102 N HIS 269 86. .483 23. .080 28 .626 1 .00 30. .83 1SG2103
ATOM 2103 CA HIS 269 85. .965 24, .048 29 .558 1 .00 30. .83 1SG2104
ATOM 2104 NDl HIS 269 87, .603 26, .288 27, .488 1, .00 30. .83 1SG2105
ATOM 2105 CG HIS 269 86, .905 26, .277 28, .675 1. .00 30. .83 1SG2106
ATOM 2106 CB HIS 269 85, .693 25. .436 28, .941 1. .00 30, .83 1SG2107
ATOM 2107 NE2 HIS 269 88, .598 27. .762 28, .823 1, .00 30. .83 1SG2108
ATOM 2108 CD2 HIS 269 87, .527 27. .183 29, .479 1. .00 30. .83 1SG2109
ATOM 2109 CE1 HIS 269 88, .604 27 .193 27 .632 1 .00 30. .83 1SG2110
ATOM 2110 C HIS 269 84, .640 23. .588 30 .085 1, .00 30, .83 1SG2111
ATOM 2111 O HIS 269 84, .339 23. .739 31, .268 1, .00 30. .83 1SG2112
ATOM 2112 N PHE 270 83, .796 23 , .037 29, .199 1, .00 30, .67 1SG2113
ATOM 2113 CA PHE 270 82, .458 22. .645 29, .547 1, .00 30, .67 1SG2114
ATOM 2114 CB PHE 270 81. .712 22 , .097 28, .319 1, .00 30. .67 1SG2115
ATOM 2115 CG PHE 270 80. .363 21 .651 28, .757 1 .00 30. .67 1SG2116
ATOM 2116 CDl PHE 270 79. .316 22 .538 28 .823 1 .00 30. .67 1SG2117
ATOM 2117 CD2 PHE 270 80, .149 20. .336 29, .102 1 .00 30. .67 1SG2118
ATOM 2118 CE1 PHE 270 78, .073 22. .115 29, .229 1, .00 30. .67 1SG2119
ATOM 2119 CE2 PHE 270 78, .908 19, .910 29, .509 1, .00 30. .67 1SG2120
ATOM 2120 CZ PHE 270 77. .865 20, .802 29, .574 1, .00 30. .67 1SG2121
ATOM 2121 C PHE 270 82. .456 21. .561 30, .584 1, .00 30. .67 1SG2122
ATOM 2122 O PHE 270 81. .808 21. .681 31 .623 1 .00 30, .67 1SG2123
ATOM 2123 N THR 271 83. .221 20. .484 30, .339 1, .00 31, .86 1SG2124
ATOM 2124 CA THR 271 83. .221 19, .322 31, .184 1, .00 31. .86 1SG2125
ATOM 2125 CB THR 271 84, .109 18, .230 30, .673 1, .00 31. .86 1SG2126
ATOM 2126 OGl THR 271 83. .697 17, .831 29, .374 1, .00 31. .86 1SG2127
ATOM 2127 CG2 THR 271 84. .019 17. .042 31, .647 1, .00 31. .86 1SG2128
ATOM 2128 C THR 271 83. .699 19 .680 32 .553 1 .00 31. .86 1SG2129
ATOM 2129 O THR 271 83. .267 19. .089 33, .541 1 .00 31. .86 1SG2130
ATOM 2130 N ALA 272 84. .628 20, .644 32, .642 1 .00 35. .32 1SG2131
ATOM 2131 CA ALA 272 85. .184 21, .078 33, .891 1, .00 35. .32 1SG2132
ATOM 2132 CB ALA 272 86. .254 22. .170 33, .726 1, .00 35. .32 1SG2133
ATOM 2133 C ALA 272 84. .085 21. .639 34. .740 1, .00 35. .32 1SG2134
ATOM 2134 O ALA 272 84. .137 21. .544 35. .964 1. .00 35. .32 1SG2135 ATOM 2135 N GLY 273 83.067 22.266 34..121 1.00 38.85 1SG2136
ATOM 2136 CA GLY 273 81. ,994 22. .837 34. .889 1. 00 38. 85 1SG2137
ATOM 2137 C GLY 273 82. ,310 24. .280 35. .127 1. ,00 38. 85 1SG2138
ATOM 2138 O GLY 273 81. .722 24. .918 36. ,000 1. 00 38. ,85 1SG2139
ATOM 2139 N VAL 274 83. ,295 24. .806 34. .377 1. ,00 43. ,43 1SG2140
ATOM 2140 CA VAL 274 83. ,734 26. ,172 34. .469 1. ,00 43. .43 1SG2141
ATOM 2141 CB VAL 274 85. .017 26. ,442 33. .732 1. ,00 43. .43 1SG2142
ATOM 2142 CGI VAL 274 86. .134 25. .554 34. .302 1. ,00 43. .43 1SG2143
ATOM 2143 CG2 VAL 274 84. .768 26. .271 32. .226 1. .00 43. ,43 1SG2144
ATOM 2144 C VAL 274 82. .732 27. .123 33. .893 1. .00 43. .43 1SG2145
ATOM 2145 O VAL 274 82. .586 28. .231 34, .405 1. .00 43. .43 1SG2146
ATOM 2146 N PHE 275 82. .034 26. .752 32, .797 •1. .00 45. .73 1SG2147
ATOM 2147 CA PHE 275 81. .179 27. .726 32, .172 1. .00 45. .73 1SG2148
ATOM 2148 CB PHE 275 80. .767 27. .348 30, .735 1. .00 45. .73 1SG2149
ATOM 2149 CG PHE 275 80. .109 28. .527 30, .093 1. .00 45. .73 1SG2150
ATOM 2150 CDl PHE 275 78. .756 28. .757 30, .216 1. .00 45. .73 1SG2151
ATOM 2151 CD2 PHE 275 80. .864 29, ,410 29, .356 1. .00 45. .73 1SG2152
ATOM 2152 CE1 PHE 275 78, .173 29, .848 29, .612 1, .00 45. .73 1SG2153
ATOM 2153 CE2 PHE 275 80. .288 30, ,502 28 .751 1, .00 45, .73 1SG2154
ATOM 2154 CZ PHE 275 78. .938 30, .723 28 .877 1. .00 45, .73 1SG2155
ATOM 2155 C PHE 275 79. .923 27, .871 32 .968 1. .00 45, .73 1SG2156
ATOM 2156 O PHE 275 78. .873 27, .336 32 .611 1, .00 45, .73 1SG2157
ATOM 2157 N ASN 276 80. .013 28, .646 34. .065 1. .00 45, .73 1SG2158
ATOM 2158 CA ASN 276 78. .884 28. .928 34, .901 1. .00 45, .73 1SG2159
ATOM 2159 CB ASN 276 78. .775 27. .989 36, .119 1, .00 45, .73 1SG2160
ATOM 2160 CG ASN 276 77. .450 28. .234 36, .834 1, .00 45, .73 1SG2161
ATOM 2161 ODl ASN 276 77. .172 29. .324 37, .331 1, .00 45, .73 1SG2162
ATOM 2162 ND2 ASN 276 76. .599 27. .175 36, .896 1, .00 45, .73 1SG2163
ATOM 2163 C ASN 276 79. .098 30. .317 35 .416 1, .00 45, .73 1SG2164
ATOM 2164 O ASN 276 80, .236 30. .730 35, .634 1, .00 45. .73 1SG2165
ATOM 2165 N VAL 277 78, .010 31, .094 35 .598 1, .00 45, .35 1SG2166
ATOM 2166 CA VAL 277 78, .188 32, .428 36 .095 1, .00 45, .35 1SG2167
ATOM 2167 CB VAL 277 78, .270 33, .455 35 .006 1, .00 45, .35 1SG2168
ATOM 2168 CGI VAL 277 78, .361 34, .847 35 .652 1, .00 45, .35 1SG2169
ATOM 2169 CG2 VAL 277 79, .457 33, .108 34 .091 1, .00 45 .35 1SG2170
ATOM 2170 C VAL 277 77, .005 32. .787 36 .933 1 .00 45 .35 1SG2171
ATOM 2171 O VAL 277 75, .886 32. .348 36 .672 1 .00 45 .35 1SG2172
ATOM 2172 N THR 278 77, .231 33 .615 37 .972 1, .00 45 .22 1SG2173
ATOM 2173 CA THR 278 76, .139 34, .025 38 .799 1 .00 45 .22 1SG2174
ATOM 2174 CB THR 278 76 .339 33 .740 40 .260 1, .00 45 .22 1SG2175
ATOM 2175 OGl THR 278 75 .109 33 .885 40 .952 1 .00 45 .22 1SG2176
ATOM 2176 CG2 THR 278 77 .384 34 .712 40 .835 1 .00 45 .22 1SG2177
ATOM 2177 C THR 278 75 .995 35 .501 38 .618 1 .00 45 .22 1SG2178
ATOM 2178 O THR 278 76 .973 36 .248 38 .605 1, .00 45 .22 1SG2179
ATOM 2179 N LEU 279 74 .746 35 .960 38 .441 1, .00 44 .45 1SG2180
ATOM 2180 CA LEU 279 74, .511 37, .352 38, .216 1, .00 44, .45 1SG2181
ATOM 2181 CB LEU 279 73, .669 37, .560 36, .948 1, .00 44, .45 1SG2182
ATOM 2182 CG LEU 279 74, .374 36, .967 35 .708 1, .00 44, .45 1SG2183
ATOM 2183 CD2 LEU 279 75, .714 37, .664 35 .441 1. .00 44, .45 1SG2184
ATOM 2184 CDl LEU 279 73, .476 36, .978 34 .472 1, .00 44, .45 1SG2185
ATOM 2185 C LEU 279 73, .762 37, .857 39 .403 1, .00 44, .45 1SG2186
ATOM 2186 O LEU 279 72, .775 37, .255 39 .824 1, .00 44, .45 1SG2187
ATOM 2187 N SER 280 74, .231 38, .979 39 .981 1, .00 42, .36 1SG2188
ATOM 2188 CA SER 280 73, .604 39 .541 41 .139 1, .00 42, .36 1SG2189
ATOM 2189 CB SER 280 74, .569 39, .757 42 .320 1, .00 42, .36 1SG2190
ATOM 2190 OG SER 280 73, .872 40. .315 43 .424 1, .00 42, .36 1SG2191
ATOM 2191 C SER 280 73, .071 40. .883 40, .753 1, .00 42, .36 1SG2192 ATOM 2192 O SER 280 73..463 41..463 39..742 1.,00 42..36 1SG2193
ATOM 2193 N THR 281 72. .143 41, .403 41. .577 1. ,00 41. .62 1SG2194
ATOM 2194 CA THR 281 71. .479 42, .654 41. .344 1. .00 41. .62 1SG2195
ATOM 2195 CB THR 281 70, .443 42, .967 42. .382 1. ,00 41. .62 1SG2196
ATOM 2196 OGl THR 281 69 . .695 44. .111 41. .997 1. .00 41. .62 1SG2197
ATOM 2197 CG2 THR 281 71, .152 43, .222 43. .723 1. .00 41. .62 1SG2198
ATOM 2198 C THR 281 72. .481 43. .766 41, .373 1. .00 41, .62 1SG2199
ATOM 2199 0 THR 281 72 .335 44. .763 40, .669 1. .00 41, ,62 1SG2200
ATOM 2200 N GLU 282 73, .525 43. .620 42, .203 1, .00 40, .52 1SG2201
ATOM 2201 CA GLU 282 74, .513 44, .643 42. .395 1. .00 40, .52 1SG2202
ATOM 2202 CB GLU 282 75. .604 44. .225 43. .392 1. .00 40, .52 1SG2203
ATOM 2203 CG GLU 282 76. .658 45. .309 43. .606 1. .00 40. ,52 1SG2204
ATOM 2204 CD GLU 282 77. .683 44. .790 44. .604 1. .00 40, .52 1SG2205
ATOM 2205 OEl GLU 282 77. .641 43, .570 44. .916 1. .00 40. ,52 1SG2206
ATOM 2206 OE2 GLU 282 78. .524 45. .607 45. ,064 1. .00 40, .52 1SG2207
ATOM 2207 C GLU 282 75. .201 44. .950 41. .101 1. .00 40, .52 1SG2208
ATOM 2208 O GLU 282 75. .598 46. .088 40. .856 1. .00 40, .52 1SG2209
ATOM 2209 N GLU 283 75. .364 43. .937 40. .236 1. .00 41, ,84 1SG2210
ATOM 2210 CA GLU 283 76. .110 44. .087 39. , 019. 1. .00 41, .84 1SG2211
ATOM 2211 CB GLU 283 76. .192 42. .788 38. .197 1. .00 41, .84 1SG2212
ATOM 2212 CG GLU 283 77, .041 41. .692 38. .843 1. .00 41, .84 1SG2213
ATOM 2213 CD GLU 283 77. .022 40 .486 37. .914 1. .00 41, .84 1SG2214
ATOM 2214 OEl GLU 283 76. .380 40. .583 36. .834 1. .00 41, .84 1SG2215
ATOM 2215 OE2 GLU 283 77. .646 39, .451 38. .272 1. .00 41. .84 1SG2216
ATOM 2216 C GLU 283 75. .521 45, .130 38. .111 1. .00 41. .84 1SG2217
ATOM 2217 O GLU 283 76. .268 45. .799 37. .397 1. .00 41. ,84 1SG2218
ATOM 2218 N ILE 284 74. .183 45, .304 38. .071 1. .00 46. .11 1SG2219
ATOM 2219 CA ILE 284 73. .671 46, .225 37, .088 1. .00 46, .11 1SG2220
ATOM 2220 CB ILE 284 72. .571 45. .647 36. .244 1. .00 46. .11 1SG2221
ATOM 2221 CG2 ILE 284 73. .155 44, .470 35. .445 1. .00 46. .11 1SG2222
ATOM 2222 CGI ILE 284 71. .360 45, .271 37, .113 1. .00 46. .11 1SG2223
ATOM 2223 CDl ILE 284 70. .113 44. .928 36, .300 1, .00 46. .11 1SG2224
ATOM 2224 C ILE 284 73. .151 47 .485 37. .714 1, .00 46. .11 1SG2225
ATOM 2225 0 ILE 284 72, .402 47, .463 38. .688 1 .00 46. .11 1SG2226
ATOM 2226 N SER 285 73 .608 48 .632 37. .166 1, .00 48. ,60 1SG2227
ATOM 2227 CA SER 285 73, .256 49, .960 37, .590 1 .00 48. .60 1SG2228
ATOM 2228 CB SER 285 74, .290 51 .004 37, .133 1, .00 48, .60 1SG2229
ATOM 2229 OG SER 285 75, .558 50. .720 37, .705 1 .00 48, .60 1SG2230
ATOM 2230 C SER 285 71, .918 50 .428 37. .065 1, .00 48, ,60 1SG2231
ATOM 2231 0 SER 285 71, .233 51 .202 37, .731 1 .00 48, .60 1SG2232
ATOM 2232 N ASN 286 71. .511 49 .980 35, .859 1, .00 51, .16 1SG2233
ATOM 2233 CA ASN 286 70. .372 50. .523 35. .153 1 .00 51, .16 1SG2234
ATOM 2234 CB ASN 286 70. .370 50 .172 33 .653 1, .00 51, .16 1SG2235
ATOM 2235 CG ASN 286 70. .260 48 .660 33, .513 1. .00 51, .16 1SG2236
ATOM 2236 ODl ASN 286 70. .443 47 .919 34 .477 1, .00 51, .16 1SG2237
ATOM 2237 ND2 ASN 286 69. .963 48 .186 32, .273 1, .00 51, .16 1SG2238
ATOM 2238 C ASN 286 69. .038 50 .124 35 .709 1, .00 51, .16 1SG2239
ATOM 2239 O ASN 286 68. .919 49 .558 36 .794 1, .00 51, .16 1SG2240
ATOM 2240 N HIS 287 67. .991 50, .480 34 .926 1. .00 51, .26 1SG2241
ATOM 2241 CA HIS 287 66. .586 50 .362 35 .214 1, .00 51. .26 1SG2242
ATOM 2242 NDl HIS 287 63. .636 51 .932 35 .013 1, .00 51. .26 1SG2243
ATOM 2243 CG HIS 287 64. .253 50 .901 34 .340 1, .00 51. .26 1SG2244
ATOM 2244 CB HIS 287 65. .722 50 .858 34, .040 1, .00 51. .26 1SG2245
ATOM 2245 NE2 HIS 287 62. .046 50 .464 34 .503 1, .00 51. .26 1SG2246
ATOM 2246 CD2 HIS 287 63, .268 50 .013 34, .036 1 .00 51. .26 1SG2247
ATOM 2247 CE1 HIS 287 62. .317 51 .620 35, .082 1. .00 51, .26 1SG2248
ATOM 2248 C HIS 287 66. .199 48. .946 35. .490 1. .00 51. .26 1SG2249 ATOM 2249 O HIS 287 65..502 48..683 36..469 1..00 51..26 1SG2250
ATOM 2250 N PHE 288 66. .624 47. .983 34. .652 1. .00 50, .72 1SG2251
ATOM 2251 CA PHE 288 66. .224 46. .645 34. .977 1. .00 50. .72 1SG2252
ATOM 2252 CB PHE 288 66. .672 45. .554 33. .980 1. .00 50. .72 1SG2253
ATOM 2253 CG PHE 288 65. .848 45. .644 32. .744 1. .00 50. .72 1SG2254
ATOM 2254 CDl PHE 288 64. .602 45. .065 32, .700 1. .00 50, .72 1SG2255
ATOM 2255 CD2 PHE 288 66, .324 46. .290 31, .627 1. .00 50, .72 1SG2256
ATOM 2256 CE1 PHE 288 63, .837 45. .139 31, .562 1. .00 50, .72 1SG2257
ATOM 2257 CE2 PHE 288 65, .563 46. .368 30 .485 1 .00 50, .72 1SG2258
ATOM 2258 CZ PHE 288 64. .316 45. .793 30 .452 1 .00 50 .72 1SG2259
ATOM 2259 C PHE 288 66, .864 46. .307 36 .276 1 .00 50 .72 1SG2260
ATOM 2260 O PHE 288 67. .989 46. .714 36. .556 1, .00 50, .72 1SG2261
ATOM 2261 N VAL 289 66. .134 45. .571 37, .128 1, .00 51, .39 1SG2262
ATOM 2262 CA VAL 289 66. .688 45, .190 38, .388 1. .00 51, .39 1SG2263
ATOM 2263 CB VAL 289 66. .185 46, .040 39, .517 1. .00 51, .39 1SG2264
ATOM 2264 CGI VAL 289 66. .820 47, .435 39, .381 1, .00 51, .39 1SG2265
ATOM 2265 CG2 VAL 289 64. .654 46, .114 39, .417 1. .00 51, .39 1SG2266
ATOM 2266 C VAL 289 66, .335 43, .760 38, .629 1. .00 51 .39 1SG2267
ATOM 2267 O VAL 289 65, .237 43, .317 38, .296 1, .00 51 .39 1SG2268
ATOM 2268 N GLN 290 67, .281 42, .990 39, .204 1, .00 56 .85 1SG2269
ATOM 2269 CA GLN 290 66. .994 41. .612 39. .467 1, .00 56, .85 1SG2270
ATOM 2270 CB GLN 290 68. .253 40. .730 39. .501 1, .00 56, .85 1SG2271
ATOM 2271 CG GLN 290 68. .976 40. .638 38, .157 1, .00 56, .85 1SG2272
ATOM 2272 CD GLN 290 70. .190 39. .739 38, .344 1, .00 56 .85 1SG2273
ATOM 2273 OEl GLN 290 70, .588 39. .441 39, .469 1, .00 56 .85 1SG2274
ATOM 2274 NE2 GLN 290 70. .799 39, .297 37, .212 1 .00 56 .85 1SG2275
ATOM 2275 C GLN 290 66. .386 41, .560 40, .827 1 .00 56 .85 1SG2276
ATOM 2276 O GLN 290 67. .056 41, .289 41, .821 1 .00 56 .85 1SG2277
ATOM 2277 N ASN 291 65. .074 41 .822 40 .898 1 .00 66 .76 1SG2278
ATOM 2278 CA ASN 291 64. .378 41. .786 42, .149 1, .00 66, .76 1SG2279
ATOM 2279 CB ASN 291 64. .419 43. .112 42, .933 1, .00 66, .76 1SG2280
ATOM 2280 CG ASN 291 63, .928 44 , .230 42, .037 1, .00 66, .76 1SG2281
ATOM 2281 ODl ASN 291 63 , .655 44 , .018 40, .858 1, .00 66, .76 1SG2282
ATOM 2282 ND2 ASN 291 63, .873 45. .469 42, .592 1, .00 66, .76 1SG2283
ATOM 2283 C ASN 291 62, .970 41. .363 41, .877 1, .00 66 .76 1SG2284
ATOM 2284 O ASN 291 62, .501 41. .437 40, .742 1 .00 66 .76 1SG2285
ATOM 2285 N SER 292 62, .278 40, .861 42, .921 1 .00 75 .80 1SG2286
ATOM 2286 CA SER 292 60, .929 40, .379 42, .803 1 .00 75 .80 1SG2287
ATOM 2287 CB SER 292 60. .380 39, .821 44. .125 1, .00 75, .80 1SG2288
ATOM 2288 OG SER 292 61. .146 38 , .700 44. .533 1, .00 75, .80 1SG2289
ATOM 2289 C SER 292 60. .067 41, .529 42. .426 1, .00 75, .80 1SG2290
ATOM 2290 O SER 292 59. .225 41, .426 41, .536 1, .00 75, .80 1SG2291
ATOM 2291 N GLN 293 60. .287 42 , .691 43 , .071 1, .00 82, .41 1SG2292
ATOM 2292 CA GLN 293 59. .549 43 , .845 42, .647 1, .00 82, .41 1SG2293
ATOM 2293 CB GLN 293 59. .745 45, .098 43. .515 1, .00 82, .41 1SG2294
ATOM 2294 CG GLN 293 61, .159 45, .666 43. .444 1, .00 82, .41 1SG2295
ATOM 2295 CD GLN 293 61, .187 47, .013 44. .143 1, .00 82, .41 1SG2296
ATOM 2296 OEl GLN 293 62. .091 47. .322 44. .918 1. .00 82. .41 1SG2297
ATOM 2297 NE2 GLN 293 60. .161 47. .852 43. .844 1. .00 82. .41 1SG2298
ATOM 2298 C GLN 293 60. .173 44. .123 41. .327 1. .00 82, .41 1SG2299
ATOM 2299 O GLN 293 61. .183 43. .548 41. .004 1. .00 82. .41 1SG2300
ATOM 2300 N GLY 294 59. .629 44. .914 40. .424 1. .00 78. .65 1SG2301
ATOM 2301 CA GLY 294 60. .413 45. .053 39. .226 1. .00 78. .65 1SG2302
ATOM 2302 C GLY 294 59. .994 43. .946 38, .308 1. .00 78. .65 1SG2303
ATOM 2303 O GLY 294 59. .385 44. .178 37, .268 1. .00 78. .65 1SG2304
ATOM 2304 N LEU 295 60. .288 42. .695 38, .716 1. .00 69. .10 1SG2305
ATOM 2305 CA LEU 295 59. .875 41. .512 38. ,032 1. .00 69. ,10 1SG2306 ATOM 2306 CB LEU 295 60..454 40..211 38..614 1..00 69..10 1SG2307
ATOM 2307 CG LEU 295 61. .975 40. .077 38. .418 1. .00 69, .10 1SG2308
ATOM 2308 CD2 LEU 295 62. .372 40. .367 36. .962 1. .00 69. .10 1SG2309
ATOM 2309 CDl LEU 295 62. .491 38. .719 38. .922 1. .00 69. .10 1SG2310
ATOM 2310 C LEU 295 58. .406 41. .491 38. .224 1. .00 69. .10 1SG2311
ATOM 2311 O LEU 295 57. .666 40. .889 37. .452 1. .00 69. .10 1SG2312
ATOM 2312 N GLY 296 57. .961 42, .156 39, .303 1. .00 60. .37 1SG2313
ATOM 2313 CA GLY 296 56. .569 42. .186 39, .646 1. .00 60, .37 1SG2314
ATOM 2314 C GLY 296 55. .807 42. .790 38. .517 1. .00 60, .37 1SG2315
ATOM 2315 O GLY 296 54, .647 42. .448 38, .286 1. .00 60 .37 1SG2316
ATOM 2316 N ASN 297 56. .416 43. .743 37, .795 1. .00 55, .28 1SG2317
ATOM 2317 CA ASN 297 55. .651 44. .347 36. .744 1. .00 55, .28 1SG2318
ATOM 2318 CB ASN 297 56, .473 45, .393 35, .982 1, .00 55, .28 1SG2319
ATOM 2319 CG ASN 297 56, .798 46, .506 36, .965 1, .00 55 .28 1SG2320
ATOM 2320 ODl ASN 297 57. .956 46. .719 37, .321 1. .00 55 .28 1SG2321
ATOM 2321 ND2 ASN 297 55. .745 47. .235 37. .424 1. .00 55, .28 1SG2322
ATOM 2322 C ASN 297 55. .226 43. .293 35, .757 1, .00 55 .28 1SG2323
ATOM 2323 o ASN 297 54. .049 43. .207 35, .401 1. .00 55 .28 1SG2324
ATOM 2324 N VAL 298 56. .186 42. .492 35. .254 1. .00 58 .41 1SG2325
ATOM 2325 CA VAL 298 55. .895 41, .473 34. .279 1. .00 58 .41 1SG2326
ATOM 2326 CB VAL 298 57. .083 41, .138 33. .428 1. .00 58 .41 1SG2327
ATOM 2327 CGI VAL 298 56. .671 40. .029 32. .446 1. .00 58, .41 1SG2328
ATOM 2328 CG2 VAL 298 57. .566 42, .423 32. .734 1, .00 58 .41 1SG2329
ATOM 2329 C VAL 298 55. .360 40, .174 34. .834 1, .00 58 .41 1SG2330
ATOM 2330 O VAL 298 54, .417 39, .622 34. .266 1. .00 58, .41 1SG2331
ATOM 2331 N LEU 299 55. .965 39, .628 35 .921 1. .00 63 .46 1SG2332
ATOM 2332 CA LEU 299 55, .567 38, .324 36. .399 1, .00 63 .46 1SG2333
ATOM 2333 CB LEU 299 56, .711 37, .295 36. .417 1. .00 63 .46 1SG2334
ATOM 2334 CG LEU 299 57. .209 36. .806 35. .047 1. .00 63, .46 1SG2335
ATOM 2335 CD2 LEU 299 57. .798 37. .938 34, .194 1, .00 63 .46 1SG2336
ATOM 2336 CDl LEU 299 56, .117 36. .005 34, .333 1. .00 63 .46 1SG2337
ATOM 2337 C LEU 299 55. .128 38. .388 37, .830 1. .00 63, .46 1SG2338
ATOM 2338 O LEU 299 55. .890 37 .985 38 .708 1, .00 63 .46 1SG2339
ATOM 2339 N SER 300 53, .874 38, .800 38, .077 1. .00 65 .07 1SG2340
ATOM 2340 CA SER 300 53. .400 38, .907 39, .425 1. .00 65, .07 1SG2341
ATOM 2341 CB SER 300 52. .233 39 .890 39 .620 1, .00 65 .07 1SG2342
ATOM 2342 OG SER 300 52, .644 41, .223 39, .356 1. .00 65 .07 1SG2343
ATOM 2343 C SER 300 52, .877 37, .593 39, .836 1. .00 65, .07 1SG2344
ATOM 2344 O SER 300 51, .693 37 .278 39 .716 1, .00 65 .07 1SG2345
ATOM 2345 N ARG 301 53. .837 36, .831 40 .351 1. .00 63 .55 1SG2346
ATOM 2346 CA ARG 301 53. .827 35, .534 40, .886 1. .00 63, .55 1SG2347
ATOM 2347 CB ARG 301 54. .103 34, .469 39, .831 1. .00 63, .55 1SG2348
ATOM 2348 CG ARG 301 53. .420 33, .133 40, .113 1. .00 63, .55 1SG2349
ATOM 2349 CD ARG 301 51. .907 33, .211 39, .886 1. .00 63, .55 1SG2350
ATOM 2350 NE ARG 301 51, .343 31, .831 39, .907 1. .00 63, .55 1SG2351
ATOM 2351 CZ ARG 301 49, .993 31, .665 39 .803 1. .00 63 .55 1SG2352
ATOM 2352 NHl ARG 301 49. .181 32, .763 39, .749 1. .00 63. .55 1SG2353
ATOM 2353 NH2 ARG 301 49. .450 30, .413 39, .743 1. .00 63, .55 1SG2354
ATOM 2354 C ARG 301 55. .067 35, .708 41, .697 1, .00 63 .55 1SG2355
ATOM 2355 O ARG 301 55. .122 35, .433 42, .890 1. .00 63, .55 1SG2356
ATOM 2356 N ILE 302 56. .105 36, .277 41, .044 1. .00 57, .81 1SG2357
ATOM 2357 CA ILE 302 57, .350 36, .533 41, .701 1, .00 57, .81 1SG2358
ATOM 2358 CB ILE 302 58. .333 37, .199 40, .782 1. .00 57, .81 1SG2359
ATOM 2359 CG2 ILE 302 59. .603 37, .527 41. .582 1. .00 57, .81 1SG2360
ATOM 2360 CGI ILE 302 58. .602 36, .301 39, .564 1. ,00 57, .81 1SG2361
ATOM 2361 CDl ILE 302 59. .373 37, .011 38, .452 1. .00 57, .81 1SG2362
ATOM 2362 C ILE 302 57. .101 37, .456 42. .858 1. .00 57, .81 1SG2363 ATOM 2363 O ILE 302 57..560 37.209 43,.972 1..00 57,.81 1SG2364
ATOM 2364 N ALA 303 56. .378 38, .564 42, .624 1. .00 55, .18 1SG2365
ATOM 2365 CA ALA 303 56 .042 39 .476 43 .680 1 .00 55 .18 1SG2366
ATOM 2366 CB ALA 303 55 .396 40 .771 43 .157 1, .00 55 .18 1SG2367
ATOM 2367 C ALA 303 55 .056 38 .810 44 .592 1, .00 55 .18 1SG2368
ATOM 2368 O ALA 303 55. .123 38 .938 45 .814 1 .00 55 .18 1SG2369
ATOM 2369 N GLU 304 54. .105 38 .072 43 .992 1 .00 58 .71 1SG2370
ATOM 2370 CA GLU 304 53. .001 37 .475 44 .688 1, .00 58 .71 1SG2371
ATOM 2371 CB GLU 304 52, .068 36 .727 43, .720 1, .00 58 .71 1SG2372
ATOM 2372 CG GLU 304 50, .739 36 .272 44 .326 1, .00 58 .71 1SG2373
ATOM 2373 CD GLU 304 49, .721 37 .380 44, .096 1, .00 58 .71 1SG2374
ATOM 2374 OEl GLU 304 50 .020 38 .268 43 .247 1 .00 58 .71 1SG2375
ATOM 2375 OE2 GLU 304 48, .646 37 .362 44 .744 1 .00 58 .71 1SG2376
ATOM 2376 C GLU 304 53, .425 36 .464 45 .713 1. .00 58 .71 1SG2377
ATOM 2377 O GLU 304 53, .011 36 .572 46 .867 1, .00 58 .71 1SG2378
ATOM 2378 N ILE 305 54, .258 35 .457 45 .347 1, .00 64 .38 1SG2379
ATOM 2379 CA ILE 305 54, .484 34 .434 46 .330 1, .00 64 .38 1SG2380
ATOM 2380 CB ILE 305 54. .047 33 .072 45 .878 1, .00 64 .38 1SG2381
ATOM 2381 CG2 ILE 305 55. .051 32, .531 44, .852 1, .00 64 .38 1SG2382
ATOM 2382 CGI ILE 305 53. .858 32, .167 47, .105 1, .00 64 .38 1SG2383
ATOM 2383 CDl ILE 305 53, .157 30 .846 46 .796 1 .00 64 .38 1SG2384
ATOM 2384 C ILE 305 55, .891 34 .389 46 .847 1 .00 64 .38 1SG2385
ATOM 2385 O ILE 305 56, .276 33 .448 47 .549 1 .00 64 .38 1SG2386
ATOM 2386 N TYR 306 56, .688 35 .418 46 .522 1 .00 72 .84 1SG2387
ATOM 2387 CA TYR 306 57, .888 35 .695 47, .249 1, .00 72 .84 1SG2388
ATOM 2388 CB TYR 306 59. .206 35, .010 46. .847 1, .00 72 .84 1SG2389
ATOM 2389 CG TYR 306 59. .437 33, .932 47. .876 1, .00 72 .84 1SG2390
ATOM 2390 CDl TYR 306 60. .119 34, .240 49, .037 1. .00 72 .84 1SG2391
ATOM 2391 CD2 TYR 306 58. .972 32, .642 47, .726 1, .00 72, .84 1SG2392
ATOM 2392 CE1 TYR 306 60 .367 33 .303 50 .013 1, .00 72 .84 1SG2393
ATOM 2393 CE2 TYR 306 59. .217 31 .693 48 .702 1, .00 72 .84 1SG2394
ATOM 2394 CZ TYR 306 59. .917 32 .020 49. .844 1, .00 72 .84 1SG2395
ATOM 2395 OH TYR 306 60, .176 31, .059 50, .847 1. .00 72 .84 1SG2396
ATOM 2396 C TYR 306 57, .942 37. .170 47, .411 1. .00 72, .84 1SG2397
ATOM 2397 O TYR 306 58, .293 37. .926 46, .503 1. .00 72, .84 1SG2398
ATOM 2398 N ILE 307 57. .571 37. .569 48. .641 1. .00 76, .49 1SG2399
ATOM 2399 CA ILE 307 57. .328 38. .896 49, .121 1. .00 76, .49 1SG2400
ATOM 2400 CB ILE 307 57. .237 38, .993 50. .621 1. .00 76, .49 1SG2401
ATOM 2401 CG2 ILE 307 56. .030 38 .156 51. .064 1. .00 76 .49 1SG2402
ATOM 2402 CGI ILE 307 58, .547 38, .575 51, .304 1. .00 76, .49 1SG2403
ATOM 2403 CDl ILE 307 58, .538 38, .869 52 , .803 1. .00 76, .49 1SG2404
ATOM 2404 C ILE 307 58, .295 39, .909 48, .636 1. .00 76, .49 1SG2405
ATOM 2405 O ILE 307 59. .506 39, .711 48 , .578 1. .00 76, .49 1SG2406
ATOM 2406 N LEU 308 57. .702 41, .076 48. .337 1. .00 74. .00 1SG2407
ATOM 2407 CA LEU 308 58. .291 42, .244 47, .772 1. .00 74. .00 1SG2408
ATOM 2408 CB LEU 308 57. .471 43. .506 48. .105 1. ,00 74. .00 1SG2409
ATOM 2409 CG LEU 308 58. ,093 44. .827 47. .622 1. ,00 74. .00 1SG2410
ATOM 2410 CD2 LEU 308 57. .389 46. .030 48. .271 1. .00 74. .00 1SG2411
ATOM 2411 CDl LEU 308 58. .144 44, .897 46. .087 1. .00 74. .00 1SG2412
ATOM 2412 C LEU 308 59. .656 42. .452 48. .317 1. .00 74. .00 1SG2413
ATOM 2413 O LEU 308 59. .978 42 , .085 49. .444 1. .00 74. .00 1SG2414
ATOM 2414 N SER 309 60. .493 43. .058 47. .462 1. .00 69. .73 1SG2415
ATOM 2415 CA SER 309 61. ,829 43. .455 47. .774 1. .00 69. .73 1SG2416
ATOM 2416 CB SER 309 61. .887 44. .433 48. .959 1. .00 69. .73 1SG2417
ATOM 2417 OG SER 309 61. .098 45. ,583 48. .692 1. 00 69. .73 1SG2418
ATOM 2418 C SER 309 62. .738 42. ,314 48. .088 1. 00 69. 73 1SG2419
ATOM 2419 O SER 309 63. ,618 42. .446 48. .939 1. ,00 69. .73 1SG2420 ATOM 2420 N GLN 310 62..579 41..160 47..417 1..00 60..79 1SG2421
ATOM 2421 CA GLN 310 63. .614 40. .196 47, .623 1. .00 60. .79 1SG2422
ATOM 2422 CB GLN 310 63. .161 38. .740 47. .822 1. .00 60. .79 1SG2423
ATOM 2423 CG GLN 310 62. .480 38, .516 49. .172 1. .00 60. .79 1SG2424
ATOM 2424 CD GLN 310 62, .365 37. .018 49. .401 1. .00 60, .79 1SG2425
ATOM 2425 OEl GLN 310 61. .968 36. ,258 48 , .518 1. .00 60. .79 1SG2426
ATOM 2426 NE2 GLN 310 62, .744 36. .577 50. .630 1. .00 60. .79 1SG2427
ATOM 2427 C GLN 310 64, .474 40. .276 46 .406 1. .00 60. .79 1SG2428
ATOM 2428 O GLN 310 64. .015 40. .644 45, .323 1. .00 60, .79 1SG2429
ATOM 2429 N PRO 311 65. .733 39. .995 46, .587 1. .00 53, .25 1SG2430
ATOM 2430 CA PRO 311 66. .645 40, .044 45, .484 1. .00 53, .25 1SG2431
ATOM 2431 CD PRO 311 66, .400 40. .279 47, .845 1. .00 53. .25 1SG2432
ATOM 2432 CB PRO 311 68 .051 40, .149 46 .085 1. .00 53 .25 1SG2433
ATOM 2433 CG PRO 311 67, .858 39, .869 47 .586 1. .00 53. .25 1SG2434
ATOM 2434 C PRO 311 66, .437 38. .860 44, .612 1. .00 53. .25 1SG2435
ATOM 2435 O PRO 311 65 .833 37, .881 45 .047 1, .00 53 .25 1SG2436
ATOM 2436 N PHE 312 66 .911 38 .957 43 .363 1 .00 48 .40 1SG2437
ATOM 2437 CA PHE 312 66. .747 37. .925 42, .395 1, .00 48. .40 1SG2438
ATOM 2438 CB PHE 312 65, .950 38, .473 41 .207 1, .00 48 .40 1SG2439
ATOM 2439 CG PHE 312 66 .052 37, .486 40 .123 1 .00 48 .40 1SG2440
ATOM 2440 CDl PHE 312 65 .278 36, .360 40 .167 1, .00 48 .40 1SG2441
ATOM 2441 CD2 PHE 312 66, .913 37, .703 39. .073 1. .00 48, .40 1SG2442
ATOM 2442 CE1 PHE 312 65 .375 35, .445 39 .160 1, .00 48 .40 1SG2443
ATOM 2443 CE2 PHE 312 67, .010 36. .784 38. .060 1, .00 48, .40 1SG2444
ATOM 2444 CZ PHE 312 66 .237 35. .652 38 .110 1, .00 48 .40 1SG2445
ATOM 2445 C PHE 312 68 .117 37, .565 41 .923 1, .00 48 .40 1SG2446
ATOM 2446 O PHE 312 68, .920 38, .448 41, .630 1, .00 48, .40 1SG2447
ATOM 2447 N MET 313 68 .433 36, .255 41 .847 1, .00 43 .53 1SG2448
ATOM 2448 CA MET 313 69 .737 35 .891 41 .375 1 .00 43 .53 1SG2449
ATOM 2449 CB MET 313 70, .617 35. .161 42 .407 1, .00 43 .53 1SG2450
ATOM 2450 CG MET 313 70 .214 33, .709 42. .665 1, .00 43, .53 1SG2451
ATOM 2451 SD MET 313 71 .266 32, .856 43 .879 1 .00 43 .53 1SG2452
ATOM 2452 CE MET 313 70 .623 31, .196 43. .525 1, .00 43, .53 1SG2453
ATOM 2453 C MET 313 69, .552 34 .975 40 .210 1, .00 4 .53 1SG2454
ATOM 2454 O MET 313 68 .657 34, .131 40. .212 1, .00 43, .53 1SG2455
ATOM 2455 N VAL 314 70 .396 35, ,129 39. .169 1, .00 41, .51 1SG2456
ATOM 2456 CA VAL 314 70 .248 34, .294 38 .012 1, .00 41 .51 1SG2457
ATOM 2457 CB VAL 314 70 .021 35 .064 36 .743 1 .00 41 .51 1SG2458
ATOM 2458 CGI VAL 314 71, .258 35, ,931 36. .462 1. .00 41, .51 1SG2459
ATOM 2459 CG2 VAL 314 69 .702 34, .065 35. .618 1, .00 41 .51 1SG2460
ATOM 2460 C VAL 314 71 .502 33 .499 37 .826 1 .00 41 .51 1SG2461
ATOM 2461 O VAL 314 72 .609 34, .005 38 .010 1, .00 41, .51 1SG2462
ATOM 2462 N ARG 315 71, .356 32, .212 37, .451 1. .00 39, .31 1SG2463
ATOM . 2463 CA ARG 315 72 .515 31, .393 37 .250 1, .00 39, .31 1SG2464
ATOM 2464 CB ARG 315 72 .495 30, .084 38, .060 1, .00 39, .31 1SG2465
ATOM 2465 CG ARG 315 71 .312 29, .169 37 .738 1, .00 39 .31 1SG2466
ATOM 2466 CD ARG 315 71 .244 27, .925 38. .628 1, .00 39 .31 1SG2467
ATOM 2467 NE ARG 315 70, .745 28. .358 39, .964 1. .00 39, .31 1SG2468
ATOM 2468 CZ ARG 315 70 .346 27, .427 40, .880 1, .00 39, .31 1SG2469
ATOM 2469 NHl ARG 315 70 .416 26 .098 40 .577 1 .00 39 .31 1SG2470
ATOM 2470 NH2 ARG 315 69, .875 27. .825 42, .098 1. .00 39. .31 1SG2471
ATOM 2471 C ARG 315 72 .588 31. .040 35, .801 1. .00 39. .31 1SG2472
ATOM 2472 O ARG 315 71 .612 30, .590 35. .202 1. .00 39. .31 1SG2473
ATOM 2473 N ILE 316 73 .772 31. .252 35. .194 1. .00 35. .91 1SG2474
ATOM 2474 CA ILE 316 73 .931 30, .956 33. .801 1. .00 35. .91 1SG2475
ATOM 2475 CB ILE 316 74 .389 32. .141 32, .991 1. .00 35. .91 1SG2476
ATOM 2476 CG2 ILE 316 73, .319 33. .236 33. .127 1. .00 35. .91 1SG2477 ATOM 2477 CGI ILE 316 75.,787 32..610 33..427 1..00 35.,91 1SG2478
ATOM 2478 CDl ILE 316 76. ,424 33. 605 32. 458 1. 00 35. 91 1SG2479
ATOM 2479 C ILE 316 74. ,958 29. 873 33. .669 1. 00 35. 91 1SG2480
ATOM 2480 O ILE 316 76. .073 29. .988 34. 176 1. 00 35. .91 1SG2481
ATOM 2481 N MET 317 74. .592 28. ,768 32. ,987 1. ,00 33. ,08 1SG2482
ATOM 2482 CA MET 317 75, .519 27. .689 32. .791 1. ,00 33. ,08 1SG2483
ATOM 2483 CB MET 317 75. .300. 26. .489 33. .730 1. .00 33. .08 1SG2484
ATOM 2484 CG MET 317 73. .928 25, .825 33. .595 1. .00 33. ,08 1SG2485
ATOM 2485 SD MET 317 72. .556 26. .780 34. .309 1. .00 33. .08 1SG2486
ATOM 2486 CE MET 317 72. .984 26. .399 36, .033 1. .00 33. .08 1SG2487
ATOM 2487 C MET 317 75. ,371 27. .201 31. ,384 1. ,00 33. .08 1SG2488
ATOM 2488 O MET 317 74. ,356 27. .442 30. .732 1. ,00 33. ,08 1SG2489
ATOM 2489 N ALA 318 76. ,406 26. .503 30. .872 1. .00 30. .98 1SG2490
ATOM 2490 CA ALA 318 76. ,363 26, .020 29. .521 1. .00 30. ,98 1SG2491
ATOM 2491 CB ALA 318 77. .752 25. .883 28. .875 1. .00 30. .98 1SG2492
ATOM 2492 C ALA 318 75. ,742 24. .663 29. .533 1. .00 30. .98 1SG2493
ATOM 2493 O ALA 318 76. .164 23. .779 30. .278 1. .00 30. .98 1SG2494
ATOM 2494 N THR 319 74. .685 24. .486 28. .715 1. .00 31. .33 1SG2495
ATOM 2495 CA THR 319 73. .998 23. .229 28, .630 1. .00 31. .33 1SG2496
ATOM 2496 CB THR 319 72. ,740 23. .314 27, .815 1. .00 31. .33 1SG2497
ATOM 2497 OGl THR 319 73. .049 23. .642 26. .468 1. .00 31. .33 1SG2498
ATOM 2498 CG2 THR 319 71. .831 24. .394 28, .422 1. .00 31, .33 1SG2499
ATOM 2499 C THR 319 74. .874 22, .206 27, .971 1. .00 31. .33 1SG2500
ATOM 2500 O THR 319 75. .023 21, .093 28 .473 1, .00 31. .33 1SG2501
ATOM 2501 N GLU 320 75, .488 22 .565 26, .824 1. .00 33. .78 1SG2502
ATOM 2502 CA GLU 320 76, .289 21, .617 26 .096 1. .00 33 .78 1SG2503
ATOM 2503 CB GLU 320 75, .587 21 .067 24, .840 1, .00 33. .78 1SG2504
ATOM 2504 CG GLU 320 75, .227 22 .145 23 .817 1. .00 33 .78 1SG2505
ATOM 2505 CD GLU 320 74. .544 21 .468 22, .636 1. .00 33. .78 1SG2506
ATOM 2506 OEl GLU 320 74. .513 20 .209 22. .615 1. .00 33. .78 1SG2507
ATOM 2507 OE2 GLU 320 74. .047 22 .201 21. .740 1. .00 33. .78 1SG2508
ATOM 2508 C GLU 320 77, .542 22 .307 25. .652 1, .00 33. .78 1SG2509
ATOM 2509 O GLU 320 77. .683 23 .519 25. .810 1, .00 33. .78 1SG2510
ATOM 2510 N PRO 321 78. .475 21 .552 25. .127 1 .00 35 .86 1SG2511
ATOM 2511 CA PRO 321 79, .712 22 .134 24 .679 1, .00 35 .86 1SG2512
ATOM 2512 CD PRO 321 78 .646 20 .171 25. .549 1 .00 35 .86 1SG2513
ATOM 2513 CB PRO 321 80, .653 20 .962 24 .415 1 .00 35 .86 1SG2514
ATOM 2514 CG PRO 321 80, .147 19 .873 25, .380 1, .00 35, .86 1SG2515
ATOM 2515 C PRO 321 79, .478 23 .022 23 .503 1, .00 35, .86 1SG2516
ATOM 2516 O PRO 321 78. .787 22 .612 22, .572 1, .00 35 .86 1SG2517
ATOM 2517 N PRO 322 80, .054 24 .188 23 .501 1, .00 38 .09 1SG2518
ATOM 2518 CA PRO 322 79 .846 25 .095 22, .410 1, .00 38 .09 1SG2519
ATOM 2519 CD PRO 322 80, .388 24 .884 24 .729 1 .00 38, .09 1SG2520
ATOM 2520 CB PRO 322 80 .318 26 .464 22 .897 1, .00 38 .09 1SG2521
ATOM 2521 CG PRO 322 81 .034 26 .186 24 .233 1 .00 38 . 09 1SG2522
ATOM 2522 C PRO 322 80 .538 24 .609 21 .177 1 .00 38 .09 1SG2523
ATOM 2523 O PRO 322 81, .613 24 .020 21 .276 1, .00 38, .09 1SG2524
ATOM 2524 N ILE 323 79 .947 24 .861 19, .996 1, .00 38, .48 1SG2525
ATOM 2525 CA ILE 323 80. .543 24 .388 18 .783 1, .00 38 .48 1SG2526
ATOM 2526 CB ILE 323 79, .606 23 .591 17 .923 1, .00 38, .48 1SG2527
ATOM 2527 CG2 ILE 323 80 .322 23 .290 16, .596 1 .00 38 .48 1SG2528
ATOM 2528 CGI ILE 323 79 .130 22 .335 18 .671 1, .00 38 .48 1SG2529
ATOM 2529 CDl ILE 323 80 .266 21 .399 19 .081 1 .00 38 .48 1SG2530
ATOM 2530 C ILE 323 80 .952 25 .575 17 .983 1, .00 38 .48 1SG2531
ATOM 2531 O ILE 323 80 .258 26 .589 17, .968 1, .00 38 .48 1SG2532
ATOM 2532 N ILE 324 82, .125 25 .487 17, .326 1, .00 39, .41 1SG2533
ATOM 2533 CA ILE 324 82 .584 26 .568 16, .507 1. .00 39 .41 1SG2534 l ιo ^ flo ιΛ O ri ( n * ι ^o ^ co <n o ri (N n ιl, ιn ιo ^ ιIι ol o ri π n » ιn ^o ^ ιD ^ o ri ( rn 'f ι ^o ^ cD (ll O ri t. rl * ιn ^o ^ α) ιJ> O ri ro ro ro ro ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ Ln ιn ι ι ι ι ι Ln ιn ι ιo ιo vo iD Vo o vo vo vo vo [- r- [- r~ r- r~ t- r- [- r- eD CD co cD Cθ co θ- eD ro ιn ιn ιn ιn ιn ιn ιn _ ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn iΛ in ιn ιn ιn ιn ιn ιn ιn ιn m _ ιn ιn ιn ιn ιn ιn ιn _ ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn
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ATOM 2591 CE2 PHE 331 87,.934 29..775 13..571 1..00 56..65 1SG2592
ATOM 2592 CZ PHE 331 88. .823 30. .634 12. .973 1. .00 56. .65 1SG2593
ATOM 2593 C PHE 331 82. .579 31. .884 12. .990 1. .00 56. .65 1SG2594
ATOM 2594 O PHE 331 82. .227 33. .030 13. .265 1. .00 56. .65 1SG2595
ATOM 2595 N THR 332 81. .796 30. .819 13. .237 1. .00 52. .01 1SG2596
ATOM 2596 CA THR 332 80 .535 31. .044 13. .875 1. .00 52. .01 1SG2597
ATOM 2597 CB THR 332 79 .363 30. .690 13, .013 1. .00 52, .01 1SG2598
ATOM 2598 OGl THR 332 78, .172 31. .249 13, .537 1. .00 52 .01 1SG2599
ATOM 2599 CG2 THR 332 79, .238 29. .167 12, .990 1. .00 52, .01 1SG2600
ATOM 2600 C THR 332 80, .504 30, .165 15, .087 1, .00 52, .01 1SG2601
ATOM 2601 O THR 332 81, .041 29, .058 15, .067 1, .00 52, .01 1SG2602
ATOM 2602 N LEU 333 79, .895 30, .650 16, .191 1, .00 49, .61 1SG2603
ATOM 2603 CA LEU 333 79, .832 29. .863 17, .390 1, .00 49, .61 1SG2604
ATOM 2604 CB LEU 333 80. .583 30. .473 18. .582 1, .00 49, .61 1SG2605
ATOM 2605 CG LEU 333 82, .104 30. .314 18. .429 1, .00 49, .61 1SG2606
ATOM 2606 CD2 LEU 333 82, .851 30. .836 19. .667 1, .00 49, .61 1SG2607
ATOM 2607 CDl LEU 333 82. .592 30. .932 17. .111 1, .00 49, .61 1SG2608
ATOM 2608 C LEU 333 78 .407 29 .644 17. .785 1 .00 49 .61 1SG2609
ATOM 2609 O LEU 333 77 .551 30, .504 17. .582 1 .00 49 .61 1SG2610
ATOM 2610 N ASP 334 78 .118 28, .450 18. .345 1 .00 46 .75 1SG2611
ATOM 2611 CA ASP 334 76 .782 28, .134 18. .769 1 .00 46 .75 1SG2612
ATOM 2612 CB ASP 334 76 .205 26, .880 18. .088 1 .00 46 .75 1SG2613
ATOM 2613 CG ASP 334 74, .753 26. .703 18. .520 1, .00 46 .75 1SG2614
ATOM 2614 ODl ASP 334 74, .251 27. .553 19. .303 1, .00 46 .75 1SG2615
ATOM 2615 OD2 ASP 334 74, .127 25, .707 18. .071 1, .00 46, .75 1SG2616
ATOM 2616 C ASP 334 76, .806 27, .864 20, .247 1, .00 46, .75 1SG2617
ATOM 2617 O ASP 334 77, .199 26. .786 20, .685 1, .00 46 .75 1SG2618
ATOM 2618 N ILE 335 76, .356 28, .838 21, .060 1, .00 44, .32 1SG2619
ATOM 2619 CA ILE 335 76 .379 28 .683 22 .491 1 .00 44 .32 1SG2620
ATOM 2620 CB ILE 335 76 .845 29 .926 23, .196 1 .00 44 .32 1SG2621
ATOM 2621 CG2 ILE 335 76 .614 29 .718 24 .701 1 .00 44 .32 1SG2622
ATOM 2622 CGI ILE 335 78 .291 30 .292 22, .830 1 .00 44 .32 1SG2623
ATOM 2623 CDl ILE 335 79 .321 29, .287 23, .334 1, .00 44 .32 1SG2624
ATOM 2624 C ILE 335 74 .979 28 .500 22, .996 1 .00 44, .32 1SG2625
ATOM 2625 O ILE 335 74 .122 29, .347 22, .749 1, .00 44 .32 1SG2626
ATOM 2626 N PRO 336 74, .709 27, .372 23, .614 1, .00 39, .85 1SG2627
ATOM 2627 CA PRO 336 73 .460 27, .212 24. .320 1, .00 39, .85 1SG2628
ATOM 2628 CD PRO 336 75 .144 26, .121 23 , .016 1, .00 39, .85 1SG2629
ATOM 2629 CB PRO 336 73, .022 25, .763 24 , .115 1, .00 39, .85 1SG2630
ATOM 2630 CG PRO 336 74 .314 25 .034 23 .717 1 .00 39 .85 1SG2631
ATOM 2631 C PRO 336 73 .700 27 .547 25, .762 1 .00 39 .85 1SG2632
ATOM 2632 O PRO 336 74 .814 27 .332 26, .242 1, .00 39, .85 1SG2633
ATOM 2633 N ALA 337 72 .681 28. .031 26, .496 1, .00 35, .31 1SG2634
ATOM 2634 CA ALA 337 72 .918 28. .326 27, .879 1, .00 35, .31 1SG2635
ATOM 2635 CB ALA 337 73 .349 29. .782 28. .129 1, .00 35, .31 1SG2636
ATOM 2636 C ALA 337 71 .641 28. .118 28. .621 1, .00 35, .31 1SG2637
ATOM 2637 O ALA 337 70, .552 28. .261 28. .066 1, .00 35, .31 1SG2638
ATOM 2638 N SER 338 71, .754 27. .763 29. .915 1. .00 34, .10 1SG2639
ATOM 2639 CA SER 338 70, .587 27. .597 30. .726 1. .00 34. .10 1SG2640
ATOM 2640 CB SER 338 70, .592 26. .315 31. .578 1. .00 34. .10 1SG2641
ATOM 2641 OG SER 338 70, .507 25. .168 30. .747 1. .00 34. .10 1SG2642
ATOM 2642 C SER 338 70 .597 28. .749 31, .673 1, .00 34. .10 1SG2643
ATOM 2643 O SER 338 71 .598 29. .011 32. .338 1. .00 34, .10 1SG2644
ATOM 2644 N ILE 339 69 .472 29, .482 31. .742 1. .00 35, .56 1SG2645
ATOM 2645 CA ILE 339 69, .400 30, .612 32. .615 1, .00 35, .56 1SG2646
ATOM 2646 CB ILE 339 68, .932 31, .859 31. .923 1. .00 35. .56 1SG2647
ATOM 2647 CG2 ILE 339 68, .849 32. .978 32. .974 1. .00 35, .56 1SG2648 ATOM 2648 CGI ILE 339 69..846 32..200 30,.734 1,.00 35.56 1SG2649
ATOM 2649 CDl ILE 339 71. .298 32, .449 31, .131 1. .00 35, .56 1SG2650
ATOM 2650 C ILE 339 68 .354 30, .282 33 .628 1, .00 35 .56 1SG2651
ATOM 2651 O ILE 339 67 .200 30 .040 33 .278 1 .00 35 .56 1SG2652
ATOM 2652 N MET 340 68. .737 30, .268 34 .919 1, ,00 38 .21 1SG2653
ATOM 2653 CA MET 340 67, .811 29, .949 35. .966 1. ,00 38, .21 1SG2654
ATOM 2654 CB MET 340 68 .348 28, .898 36 .952 1, .00 38 .21 1SG2655
ATOM 2655 CG MET 340 68 .600 27, .527 36. .324 1, .00 38 .21 1SG2656
ATOM 2656 SD MET 340 67 .093 26 .632 35 .851 1 .00 38 .21 1SG2657
ATOM 2657 CE MET 340 67 .965 25, .176 35, .202 1, ,00 38 .21 1SG2658
ATOM 2658 C MET 340 67 .614 31, .197 36 .766 1 .00 38 .21 1SG2659
ATOM 2659 O MET 340 68 .540 31, .979 36, .974 1. .00 38 .21 1SG2660
ATOM 2660 N MET 341 66 .376 31 .408 37 .240 1, .00 41 .70 1SG2661
ATOM 2661 CA MET 341 66, .035 32, .584 37, .981 1, .00 41 .70 1SG2662
ATOM 2662 CB MET 341 64, .755 33, .200 37, .393 1. .00 41, .70 1SG2663
ATOM 2663 CG MET 341 64, .816 33, .417 35, .875 1, .00 41 .70 1SG2664
ATOM 2664 SD MET 341 66 .140 34 .507 35 .269 1 .00 41 .70 1SG2665
ATOM 2665 CE MET 341 65, .628 34, .435 33 .528 1. .00 41 .70 1SG2666
ATOM 2666 C MET 341 65, .720 32. .106 39. .364 1, .00 41 .70 1SG2667
ATOM 2667 0 MET 341 64, .935 31, .174 39 .536 1, .00 41 .70 1SG2668
ATOM 2668 N LEU 342 66 .338 32, .722 40 .390 1 .00 43 .13 1SG2669
ATOM 2669 CA LEU 342 66. .118 32. .278 41, .736 1. .00 43 .13 1SG2670
ATOM 2670 CB LEU 342 67. .396 31, .726 42, .386 1, .00 43 .13 1SG2671
ATOM 2671 CG LEU 342 67. .994 30, .503 41 .661 1, ,00 43 .13 1SG2672
ATOM 2672 CD2 LEU 342 68 .454 30 .855 40 .237 1 .00 43 .13 1SG2673
ATOM 2673 CDl LEU 342 67. .039 29, .300 41 .708 1, .00 4 .13 1SG2674
ATOM 2674 C LEU 342 65. .699 33 , .456 42, .552 1, .00 43 .13 1SG2675
ATOM 2675 O LEU 342 66. .060 34, .594 42 .255 1, .00 43 .13 1SG2676
ATOM 2676 N THR 343 64. .912 33, .197 43, .613 1. .00 44 .15 1SG2677
ATOM 2677 CA THR 343 64. .500 34, .235 44 .513 1, .00 44 .15 1SG2678
ATOM 2678 CB THR 343 63. .077 34, .111 44, .986 1. .00 44 .15 1SG2679
ATOM 2679 OGl THR 343 62. .183 34, .143 43 .883 1. .00 44 .15 1SG2680
ATOM 2680 CG2 THR 343 62. .778 35. .269 45, .954 1. .00 44, .15 1SG2681
ATOM 2681 C THR 343 65. .350 34. .015 45 .712 1, .00 44 .15 1SG2682
ATOM 2682 O THR 343 65. .524 32, .880 46, .148 1. .00 44 .15 1SG2683
ATOM 2683 N GLN 344 65. .930 35. ,091 46, .266 1. .00 47, .45 1SG2684
ATOM 2684 CA GLN 344 66. .788 34. .887 47, .390 1. .00 47, .45 1SG2685
ATOM 2685 CB GLN 344 68, .071 35, .731 47. .300 1. .00 47 .45 1SG2686
ATOM 2686 CG GLN 344 69. .108 35, .411 48. .375 1. .00 47, .45 1SG2687
ATOM 2687 CD GLN 344 70. .369 36. .197 48. .043 1. .00 47, .45 1SG2688
ATOM 2688 OEl GLN 344 70. .337 37. .169 47. .289 1. .00 47, .45 1SG2689
ATOM 2689 NE2 GLN 344 71, .520 35, .760 48. .619 1. .00 47, .45 1SG2690
ATOM 2690 C GLN 344 66. ,041 35. ,278 48. .624 1. .00 47. .45 1SG2691
ATOM 2691 O GLN 344 65. .686 36. .438 48. .824 1. .00 47. .45 1SG2692
ATOM 2692 N PRO 345 65. .781 34. .309 49. .455 1. .00 50. .88 1SG2693
ATOM 2693 CA PRO 345 65. .128 34, .606 50. .695 1. .00 50, .88 1SG2694
ATOM 2694 CD PRO 345 65. .370 33. .008 48. .961 1. .00 50. .88 1SG2695
ATOM 2695 CB PRO 345 64. .521 33. .293 51. .199 1. .00 50. .88 1SG2696
ATOM 2696 CG PRO 345 65. .054 32. .218 50. .237 1. ,00 50. .88 1SG2697
ATOM 2697 C PRO 345 66. .110 35. ,230 51. .633 1. ,00 50. .88 1SG2698
ATOM 2698 O PRO 345 67. .308 35. .202 51. .360 1. ,00 50. .88 1SG2699
ATOM 2699 N LYS 346 65. .616 35. ,794 52. .748 1. .00 54. .02 1SG2700
ATOM 2700 CA LYS 346 66. ,434 36. .462 53. .719 1. .00 54. .02 1SG2701
ATOM 2701 CB LYS 346 65. ,616 37. ,063 54. .874 1. 00 54. .02 1SG2702
ATOM 2702 CG LYS 346 64. ,661 36. ,076 55. .545 1. ,00 54. ,02 1SG2703
ATOM 2703 CD LYS 346 65. .349 34. ,984 56. ,362 1. 00 54. .02 1SG2704
ATOM 2704 CE LYS 346 64. 355 34. 026 57. 019 1. 00 54. 02 1SG2705 ATOM 2705 NZ LYS 346 63..461 34..777 57..928 1..00 54..02 1SG2706
ATOM 2706 C LYS 346 67. .432 35, .486 54. .269 1. .00 54. .02 1SG2707
ATOM 2707 O LYS 346 68. .497 35. .878 54. .748 1. .00 54. .02 1SG2708
ATOM 2708 N ASN 347 67. ,087 34. .186 54. .224 1. .00 55. .06 1SG2709
ATOM 2709 CA ASN 347 67. .899 33. .095 54. .699 1. .00 55. .06 1SG2710
ATOM 2710 CB ASN 347 67. .299 31. .713 54. .416 1. .00 55. .06 1SG2711
ATOM 2711 CG ASN 347 65. .828 31, .746 54, .743 1, .00 55, .06 1SG2712
ATOM 2712 ODl ASN 347 65. .067 32, .308 53. .957 1. .00 55. .06 1SG2713
ATOM 2713 ND2 ASN 347 65. .416 31, .132 55. .883 1. .00 55. .06 1SG2714
ATOM 2714 C ASN 347 69. .126 33. .069 53. .849 1. .00 55. .06 1SG2715
ATOM 2715 O ASN 347 70. .159 32. .536 54. .252 1. .00 55. .06 1SG2716
ATOM 2716 N SER 348 69. .019 33, .648 52. .637 1, .00 51. .55 1SG2717
ATOM 2717 CA SER 348 70. .024 33, .566 51. .619 1, .00 51. .55 1SG2718
ATOM 2718 CB SER 348 71. .468 33. .690 52. .143 1, .00 51. .55 1SG2719
ATOM 2719 OG SER 348 71. .687 34. .984 52. .687 1, .00 51. .55 1SG2720
ATOM 2720 C SER 348 69. .871 32. .234 50. .959 1, .00 51. .55 1SG2721
ATOM 2721 O SER 348 70, .722 31. .804 50. .182 1 .00 51. .55 1SG2722
ATOM 2722 N THR 349 68, .728 31. .570 51, .217 1, .00 48. .11 1SG2723
ATOM 2723 CA THR 349 68, .424 30, .327 50, .574 1, .00 48. .11 1SG2724
ATOM 2724 CB THR 349 67. .264 29. .621 51. .224 1. .00 48, .11 1SG2725
ATOM 2725 OGl THR 349 67. .542 29. .414 52. .601 1, .00 48, .11 1SG2726
ATOM 2726 CG2 THR 349 67. .034 28. .263 50. .539 1 .00 48 .11 1SG2727
ATOM 2727 C THR 349 68. .047 30, .703 49. .172 1 .00 48, .11 1SG2728
ATOM 2728 O THR 349 67, .947 31, .887 48. .858 1, .00 48, .11 1SG2729
ATOM 2729 N VAL 350 67. .874 29, .713 48. .272 1, .00 44, .86 1SG2730
ATOM 2730 CA VAL 350 67. .547 30, .013 46. .906 1, .00 44, .86 1SG2731
ATOM 2731 CB VAL 350 68, .595 29 .503 45. .964 1 .00 44, .86 1SG2732
ATOM 2732 CGI VAL 350 68, .744 27, .986 46, .172 1 .00 44, .86 1SG2733
ATOM 2733 CG2 VAL 350 68, .190 29, .879 44 , .536 1 .00 44, .86 1SG2734
ATOM 2734 C VAL 350 66, .263 29, .324 46, .557 1, .00 44, .86 1SG2735
ATOM 2735 O VAL 350 66, .079 28, .145 46. .854 1, .00 44, .86 1SG2736
ATOM 2736 N GLU 351 65, .330 30 .054 45. .909 1 .00 43 .40 1SG2737
ATOM 2737 CA GLU 351 64, .083 29 .449 45. .519 1 .00 43 .40 1SG2738
ATOM 2738 CB GLU 351 62, .853 30, .153 46. .120 1 .00 43, .40 1SG2739
ATOM 2739 CG GLU 351 62. .795 30, .064 47. .645 1, .00 43, .40 1SG2740
ATOM 2740 CD GLU 351 62. .657 28, .597 48. .022 1, .00 43, .40 1SG2741
ATOM 2741 OEl GLU 351 61. .986 27 .852 47. .258 1 .00 43 .40 1SG2742
ATOM 2742 OE2 GLU 351 63. .224 28, .199 49. .074 1 .00 43, .40 1SG2743
ATOM 2743 C GLU 351 63, .984 29, .566 44. .025 1 .00 43 , .40 1SG2744
ATOM 2744 O GLU 351 63, .996 30, .672 43. .487 1, .00 43, .40 1SG2745
ATOM 2745 N THR 352 63. .867 28, .421 43. .316 1, .00 43. .17 1SG2746
ATOM 2746 CA THR 352 63. .868 28, .433 41. .874 1 .00 43. .17 1SG2747
ATOM 2747 CB THR 352 64, .160 27, .091 41. .261 1, .00 43, .17 1SG2748
ATOM 2748 OGl THR 352 64 , .270 27, .212 39. .851 1, .00 43, .17 1SG2749
ATOM 2749 CG2 THR 352 63. .044 26. .100 41. .631 1, .00 43. .17 1SG2750
ATOM 2750 C THR 352 62. .579 28. .946 41. .302 1, .00 43. .17 1SG2751
ATOM 2751 O THR 352 61. .511 28. .368 41, .502 1, .00 43, .17 1SG2752
ATOM 2752 N ILE 353 62. .653 30. .107 40. .614 1, .00 42 , .01 1SG2753
ATOM 2753 CA ILE 353 61. .515 30. .685 39. .954 1, .00 42. .01 1SG2754
ATOM 2754 CB ILE 353 61. .715 32. .138 39. .647 1, .00 42. .01 1SG2755
ATOM 2755 CG2 ILE 353 60. .553 32. .599 38. .753 1, .00 42. .01 1SG2756
ATOM 2756 CGI ILE 353 61, .858 32. .937 40, .954 1, .00 42. .01 1SG2757
ATOM 2757 CDl ILE 353 62 , .362 34, .365 40. .755 1, .00 42. .01 1SG2758
ATOM 2758 C ILE 353 61, .201 29, .998 38. .650 1. .00 42. .01 1SG2759
ATOM 2759 O ILE 353 60. .082 29. .530 38. .438 1. .00 42. .01 1SG2760
ATOM 2760 N VAL 354 62. .196 29. .906 37. .737 1. .00 40. .00 1SG2761
ATOM 2761 CA VAL 354 61. .940 29. .348 36. .434 1. .00 40. .00 1SG2762 ATOM 2762 CB VAL 354 61.170 30.289 35,.548 1..00 40..00 1SG2763
ATOM 2763 CGI VAL 354 62 .027 31 .543 35 .310 1, .00 40. .00 1SG2764
ATOM 2764 CG2 VAL 354 60 .765 29 .553 34 .260 1, .00 40, .00 1SG2765
ATOM 2765 C VAL 354 63 .248 29 .055 35 .752 1. .00 40, .00 1SG2766
ATOM 2766 0 VAL 354 64 .298 29 .564 36 .139 1. .00 40, .00 1SG2767
ATOM 2767 N SER 355 63 .211 28. .211 34 , .698 1. .00 36, .48 1SG2768
ATOM 2768 CA SER 355 64 .405 27 .873 33 .970 1. .00 36, .48 1SG2769
ATOM 2769 CB SER 355 64 .692 26 .363 33 .955 1 .00 36 .48 1SG2770
ATOM 2770 OG SER 355 63 .639 25 .673 33 .300 1 .00 36 .48 1SG2771
ATOM 2771 C SER 355 64 .209 28, .296 32, .546 1. .00 36. .48 1SG2772
ATOM 2772 O SER 355 63 .151 28 .069 31, .963 1. .00 36, .48 1SG2773
ATOM 2773 N MET 356 65 .236 28 .926 31 .939 1, .00 34, .58 1SG2774
ATOM 2774 CA MET 356 65 .090 29 .384 30 .587 1 .00 34 .58 1SG2775
ATOM 2775 CB MET 356 65 .127 30, .921 30, .483 1. .00 34, .58 1SG2776
ATOM 2776 CG MET 356 64 .637 31. .482 29, .147 1, .00 34, .58 1SG2777
ATOM 2777 SD MET 356 65 .826 31 .354 27 .784 1. .00 34 .58 1SG2778
ATOM 2778 CE MET 356 66 .843 32 .760 28 .317 1 .00 34 .58 1SG2779
ATOM 2779 C MET 356 66. .197 28. .806 29, .763 1. .00 34, .58 1SG2780
ATOM 2780 O MET 356 67 .324 28. .653 30, .234 1, .00 34, .58 1SG2781
ATOM 2781 N ASP 357 65 .881 28 .445 28 .501 1. .00 32 .32 1SG2782
ATOM 2782 CA ASP 357 66 .851 27, .867 27, .615 1. .00 32, .32 1SG2783
ATOM 2783 CB ASP 357 66, .339 26, .599 26, .915 1. .00 32, .32 1SG2784
ATOM 2784 CG ASP 357 66 .165 25, .528 27, .982 1, .00 32, .32 1SG2785
ATOM 2785 ODl ASP 357 67 .014 25 .477 28 .912 1. .00 32 .32 1SG2786
ATOM 2786 OD2 ASP 357 65 .184 24, .745 27, .878 1, .00 32, .32 1SG2787
ATOM 2787 C ASP 357 67 .146 28, .878 26, .557 1. .00 32 .32 1SG2788
ATOM 2788 O ASP 357 66 .271 29, .277 25, .791 1. .00 32. .32 1SG2789
ATOM 2789 N PHE 358 68 .409 29 .333 26 .512 1. .00 32 .89 1SG2790
ATOM 2790 CA PHE 358 68 .841 30, .333 25, .583 1. .00 32. .89 1SG2791
ATOM 2791 CB PHE 358 69, .482 31. .535 26, .304 1. .00 32 .89 1SG2792
ATOM 2792 CG PHE 358 70 .602 32. .075 25, .482 1, .00 32. .89 1SG2793
ATOM 2793 CDl PHE 358 70 .412 33. .034 24, .516 1. .00 32 .89 1SG2794
ATOM 2794 CD2 PHE 358 71 .875 31. .597 25, .703 1. .00 32. .89 1SG2795
ATOM 2795 CE1 PHE 358 71, .481 33. .500 23, .785 1, .00 32 .89 1SG2796
ATOM 2796 CE2 PHE 358 72. .945 32. .059 24. .977 1. .00 32, .89 1SG2797
ATOM 2797 CZ PHE 358 72 .748 33, .015 24. .012 1. .00 32 .89 1SG2798
ATOM 2798 C PHE 358 69. .842 29. .747 24. .645 1. .00 32, .89 1SG2799
ATOM 2799 O PHE 358 70. .652 28. .902 25. .022 1. .00 32, .89 1SG2800
ATOM 2800 N VAL 359 69, .781 30. .181 23. .370 1. .00 35, .17 1SG2801
ATOM 2801 CA VAL 359 70, .708 29. .740 22. .370 1. .00 35. .17 1SG2802
ATOM 2802 CB VAL 359 70, .248 28. .519 21. .633 1. .00 35. .17 1SG2803
ATOM 2803 CGI VAL 359 70 .169 27. .351 22. .632 1. .00 35, .17 1SG2804
ATOM 2804 CG2 VAL 359 68, .910 28. .842 20. .948 1. ,00 35. .17 1SG2805
ATOM 2805 C VAL 359 70. .812 30. ,859 21. .382 1. ,00 35. ,17 1SG2806
ATOM 2806 O VAL 359 69 . .922 31. ,706 21. .307 1. .00 35. .17 1SG2807
ATOM 2807 N ALA 360 71, .912 30. .905 20. .604 1. ,00 36. .89 1SG2808
ATOM 2808 CA ALA 360 72, .069 31. .978 19. .664 1. .00 36. .89 1SG2809
ATOM 2809 CB ALA 360 72. .501 33. .304 20. .311 1. .00 36. .89 1SG2810
ATOM 2810 C ALA 360 73. .143 31. ,605 18. .690 1. ,00 36. .89 1SG2811
ATOM 2811 O ALA 360 73. .653 30. .486 18. ,709 1. ,00 36. .89 1SG2812
ATOM 2812 N SER 361 73. .467 32. .550 17. .779 1. .00 40. .76 1SG2813
ATOM 2813 CA SER 361 74. .522 32. 405 16. 814 1. 00 40. 76 1SG2814
ATOM 2814 CB ' SER 361 74. .076 32. .565 15. .351 1. 00 40. .76 1SG2815
ATOM 2815 OG SER 361 73. .263 31. .470 14. .964 1. .00 40. ,76 1SG2816
ATOM 2816 C SER 361 75. .468 33. ,526 17. .100 1. 00 40. 76 1SG2817
ATOM 2817 O SER 361 75. .061 34. 583 17. 580 1. 00 40. 76 1SG2818
ATOM 2818 N THR 362 76. .767 33. 318 16. 820 1. 00 41. 22 1SG2819 ATOM 2819 CA THR 362 77,.752 34..281 17..218 1..00 41,.22 1SG2820
ATOM 2820 CB THR 362 78, .481 33, .755 18. .423 1. .00 41, .22 1SG2821
ATOM 2821 OGl THR 362 77 .563 33 .482 19. .469 1. .00 41, .22 1SG2822
ATOM 2822 CG2 THR 362 79 .558 34 .741 18, .885 1. .00 41, .22 1SG2823
ATOM 2823 C THR 362 78 .802 34 .374 16, .158 1. .00 41, .22 1SG2824
ATOM 2824 O THR 362 78 .968 33 .469 15, .346 1. .00 41, .22 1SG2825
ATOM 2825 N SER 363 79 .566 35 .485 16, .162 1. .00 40 .62 1SG2826
ATOM 2826 CA SER 363 80 .668 35 .599 15, .258 1. .00 40, .62 1SG2827
ATOM 2827 CB SER 363 80 .621 36 .877 14, .408 1. .00 40, .62 1SG2828
ATOM 2828 OG SER 363 81, .739 36 .923 13, .535 1. .00 40, .62 1SG2829
ATOM 2829 C SER 363 81 .881 35 .683 16, .128 1. .00 40, .62 1SG2830
ATOM 2830 O SER 363 81, .898 36 .444 17, .096 1. .00 40. .62 1SG2831
ATOM 2831 N VAL 364 82 .925 34, .880 15, .837 1. .00 39. .91 1SG2832
ATOM 2832 CA VAL 364 84, .080 35 .029 16, .668 1. .00 39 .91 1SG2833
ATOM 2833 CB VAL 364 84 .507 33 .802 17, .418 1. .00 39. .91 1SG2834
ATOM 2834 CGI VAL 364 83, .391 33 .449 18, .408 1. .00 39 .91 1SG2835
ATOM 2835 CG2 VAL 364 84 .864 32 .683 16. .432 1. .00 39 .91 1SG2836
ATOM 2836 C VAL 364 85 .220 35 .494 15. .834 1. .00 39 .91 1SG2837
ATOM 2837 O VAL 364 85 .658 34 .817 14. .904 1. .00 39 .91 1SG2838
ATOM 2838 N GLY 365 85 .717 36, .703 16. .156 1. .00 38 .25 1SG2839
ATOM 2839 CA GLY 365 86, .828 37 .260 15. .449 1. .00 38 .25 1SG2840
ATOM 2840 C GLY 365 88 .073 36 .757 16. .099 1, .00 38 .25 1SG2841
ATOM 2841 O GLY 365 88 .091 36 .470 17, .295 1. .00 38 .25 1SG2842
ATOM 2842 N LEU 366 89, .165 36 .653 15. .318 1. .00 40 .12 1SG2843
ATOM 2843 CA LEU 366 90. .402 36 .218 15. .893 1. .00 40 .12 1SG2844
ATOM 2844 CB LEU 366 90, .851 34 .816 15. .440 1. .00 40 .12 1SG2845
ATOM 2845 CG LEU 366 89 .927 33 .680 15. .924 1. .00 40 .12 1SG2846
ATOM 2846 CD2 LEU 366 90 .583 32 .303 15. .732 1. .00 40 .12 1SG2847
ATOM 2847 CDl LEU 366 88, .534 33 .777 15. .283 1. .00 40 .12 1SG2848
ATOM 2848 C LEU 366 91, .474 37 .184 15. .493 1. .00 40 .12 1SG2849
ATOM 2849 O LEU 366 91. .555 37 .602 14, .338 1. .00 40 .12 1SG2850
ATOM 2850 N VAL 367 92, .328 37 .559 16, .468 1. .00 41 .20 1SG2851
ATOM 2851 CA VAL 367 93, .400 38 .488 16, .249 1. .00 41 .20 1SG2852
ATOM 2852 CB VAL 367 93 , .109 39 .856 16, .789 1. .00 41 .20 1SG2853
ATOM 2853 CGI VAL 367 91, .887 40 .423 16, .047 1. .00 41 .20 1SG2854
ATOM 2854 CG2 VAL 367 92, .916 39 .747 18, .311 1. .00 41 .20 1SG2855
ATOM 2855 C VAL 367 94 , .575 37 .974 17, .017 1. .00 41 .20 1SG2856
ATOM 2856 O VAL 367 94 , .455 37, .021 17, .785 1. .00 41, .20 1SG2857
ATOM 2857 N ILE 368 95. .761 38, .578 16, .808 1. .00 44 .41 1SG2858
ATOM 2858 CA ILE 368 96. .908 38, .089 17, .514 1. .00 44 .41 1SG2859
ATOM 2859 CB ILE 368 97. .863 37, .377 16. .591 1. .00 44, .41 1SG2860
ATOM 2860 CG2 ILE 368 98. .550 38, .425 15, .700 1. .00 44 , .41 1SG2861
ATOM 2861 CGI ILE 368 98. .828 36. .469 17, .366 1. .00 44. .41 1SG2862
ATOM 2862 CDl ILE 368 99. .727 37. .215 18, .338 1. .00 44. .41 1SG2863
ATOM 2863 C ILE 368 97. .597 39, .249 18, .170 1. .00 44. .41 1SG2864
ATOM 2864 O ILE 368 97. .806 40, .297 17, .560 1. .00 44. .41 1SG2865
ATOM 2865 N LEU 369 97. .938 39, .089 19, .464 1. .00 49. .41 1SG2866
ATOM 2866 CA LEU 369 98. .642 40, .092 20, .206 1. .00 49. .41 1SG2867
ATOM 2867 CB LEU 369 97. .822 40, .616 21. .406 1. ,00 49. .41 1SG2868
ATOM 2868 CG LEU 369 98. .401 41, .829 22. .172 1. ,00 49. .41 1SG2869
ATOM 2869 CD2 LEU 369 99. .849 41, .617 22. .646 1. ,00 49. .41 1SG2870
ATOM 2870 CDl LEU 369 97. .471 42, .221 23. .332 1. ,00 49. .41 1SG2871
ATOM 2871 C LEU 369 99. .846 39, .388 20. .733 1. .00 49. .41 1SG2872
ATOM 2872 O LEU 369 99. .731 38, .330 21. ,351 1. .00 49. .41 1SG2873
ATOM 2873 N GLY 370 101. .042 39. .953 20. ,488 1. .00 52. .45 1SG2874
ATOM 2874 CA GLY 370 102. ,232 39. .326 20. ,975 1. .00 52. .45 1SG2875
ATOM 2875 C GLY 370 102. .280 37. .932 20. .429 1. .00 52. .45 1SG2876 ATOM 2876 O GLY 370 102..264 37..711 19,.221 1,.00 52,.45 1SG2877
ATOM 2877 N GLN 371 102. .443 36. .979 21, .361 1. .00 58, .08 1SG2878
ATOM 2878 CA GLN 371 102. .499 35. .547 21. .243 1. .00 58, .08 1SG2879
ATOM 2879 CB GLN 371 103. .155 34, .946 22 .501 1 .00 58 .08 1SG2880
ATOM 2880 CG GLN 371 103. .196 33, .420 22. .592 1, .00 58, .08 1SG2881
ATOM 2881 CD GLN 371 103, .737 33, .094 23, .982 1, .00 58, .08 1SG2882
ATOM 2882 OEl GLN 371 104, .058 31 .947 24 .287 1 .00 58 .08 1SG2883
ATOM 2883 NE2 GLN 371 103, .841 34, .135 24, .854 1. .00 58 .08 1SG2884
ATOM 2884 C GLN 371 101, .144 34, .901 21, .132 1, .00 58, .08 1SG2885
ATOM 2885 O GLN 371 101, .031 33, .781 20 .633 1 .00 58 .08 1SG2886
ATOM 2886 N ARG 372 100, .099 35, .549 21, .684 1. .00 59 .48 1SG2887
ATOM 2887 CA ARG 372 98, .832 34, .890 21, .893 1. .00 59, .48 1SG2888
ATOM 2888 CB ARG 372 98. .115 35, .401 23, .149 1. .00 59, .48 1SG2889
ATOM 2889 CG ARG 372 97. .804 36, .894 23, .064 1. .00 59 .48 1SG2890
ATOM 2890 CD ARG 372 97, .180 37, .469 24, .334 1, .00 59, .48 1SG2891
ATOM 2891 NE ARG 372 98, .286 37. .703 25, .302 1. .00 59, .48 1SG2892
ATOM 2892 CZ ARG 372 98, .368 38 .894 25 .965 1. .00 59 .48 1SG2893
ATOM 2893 NHl ARG 372 97, .436 39, .865 25, .740 1. .00 59 .48 1SG2894
ATOM 2894 NH2 ARG 372 99, .387 39, .117 26, .844 1, .00 59 .48 1SG2895
ATOM 2895 C ARG 372 97, .840 34, .998 20 .776 1, .00 59 .48 1SG2896
ATOM 2896 O ARG 372 97, .924 35, .853 19, .897 1. .00 59 .48 1SG2897
ATOM 2897 N LEU 373 96, .854 34, .070 20, .817 1, .00 55 .77 1SG2898
ATOM 2898 CA LEU 373 95 .757 34, .030 19, .899 1, .00 55 .77 1SG2899
ATOM 2899 CB LEU 373 95, .470 32, .617 19, .366 1, .00 55 .77 1SG2900
ATOM 2900 CG LEU 373 94. .380 32, .568 18, .283 1, .00 55 .77 1SG2901
ATOM 2901 CD2 LEU 373 93. .970 31, .121 17, .967 1. .00 55 .77 1SG2902
ATOM 2902 CDl LEU 373 94. .812 33, .349 17, .031 1, .00 55 .77 1SG2903
ATOM 2903 C LEU 373 94. .580 34, .489 20, .699 1. .00 55 .77 1SG2904
ATOM 2904 O LEU 373 94. .180 33, .837 21. .664 1, .00 55, .77 1SG2905
ATOM 2905 N VAL 374 94. .005 35, .646 20, .320 1, .00 54 .06 1SG2906
ATOM 2906 CA VAL 374 92. .928 36, .202 21, .084 1, .00 54 .06 1SG2907
ATOM 2907 CB VAL 374 93. .228 37, .584 21. .581 1, .00 54, .06 1SG2908
ATOM 2908 CGI VAL 374 92. .022 38, .081 22. .372 1, .00 54 .06 1SG2909
ATOM 2909 CG2 VAL 374 94. .510 37, .556 22. .421 1, .00 54, .06 1SG2910
ATOM 2910 C VAL 374 91. .739 36, .308 20. .189 1, .00 54, .06 1SG2911
ATOM 2911 O VAL 374 91. .868 36, .384 18. .970 1, .00 54 .06 1SG2912
ATOM 2912 N CYS 375 90. .531 36, .284 20. .781 1, .00 50, .23 1SG2913
ATOM 2913 CA CYS 375 89. .354 36. .376 19. .974 1. .00 50, .23 1SG2914
ATOM 2914 CB CYS 375 88, .790 35, .001 19. .578 1, .00 50, .23 1SG2915
ATOM 2915 SG CYS 375 88, .521 33, .924 21. .016 1. .00 50, .23 1SG2916
ATOM 2916 C CYS 375 88. .301 37, .111 20. .732 1. .00 50, .23 1SG2917
ATOM 2917 O CYS 375 88. .467 37. .422 21. .912 1. .00 50. .23 1SG2918
ATOM 2918 N SER 376 87, .188 37. .434 20. .039 1. .00 49, .02 1SG2919
ATOM 2919 CA SER 376 86. .103 38. .133 20. .659 1. .00 49, .02 1SG2920
ATOM 2920 CB SER 376 86. .059 39. .629 20. .309 1. .00 49. .02 1SG2921
ATOM 2921 OG SER 376 84. .960 40. .247 20. .962 1. .00 49. .02 1SG2922
ATOM 2922 C SER 376 84. .831 37. .534 20. .145 1. .00 49. .02 1SG2923
ATOM 2923 O SER 376 84. .746 37. .100 18. ,997 1. .00 49. .02 1SG2924
ATOM 2924 N LEU 377 83, .802 37. .500 21. .009 1. .00 50. .64 1SG2925
ATOM 2925 CA LEU 377 82. .510 36. .971 20. ,681 1. .00 50. ,64 1SG2926
ATOM 2926 CB LEU 377 81. .846 36. .208 21. ,838 1. .00 50. .64 1SG2927
ATOM 2927 CG LEU 377 82. .221 34. .732 21. .968 1. .00 50. ,64 1SG2928
ATOM 2928 CD2 LEU 377 81. .688 33. .965 20. .754 1. ,00 50. ,64 1SG2929
ATOM 2929 CDl LEU 377 81. ,678 34. .136 23. .275 1. ,00 50. .64 1SG2930
ATOM 2930 C LEU 377 81. ,571 38. .104 20. 442 1. 00 50. ,64 1SG2931
ATOM 2931 O LEU 377 81. .600 39. .114 21. .143 1. .00 50. .64 1SG2932
ATOM 2932 N SER 378 80. .700 37. .943 19. ,430 1. ,00 47. ,68 1SG2933 ATOM 2933 CA SER 378 79..677 38.,913 19.,176 1.00 47.68 1SG2934
ATOM 2934 CB SER 378 79. .929 39. ,751 17. ,916 1. 00 47. ,68 1SG2935
ATOM 2935 OG SER 378 81. .104 40. ,529 18. .090 1. 00 47. ,68 1SG2936
ATOM 2936 C SER 378 78. ,433 38. .117 18. .955 1. 00 47. ,68 1SG2937
ATOM 2937 O SER 378 78. ,442 37. .140 18. .209 1. 00 47. .68 1SG2938
ATOM 2938 N LEU 379 77. .315 38. .513 19. .593 1. .00 46. .52 1SG2939
ATOM 2939 CA LEU 379 76. ,135 37. .701 19. .487 1. .00 46. ,52 1SG2940
ATOM 2940 CB LEU 379 75. .448 37. .424 20, .834 1. ,00 46. .52 1SG2941
ATOM 2941 CG LEU 379 76. .334 36. .703 21. .866 1. ,00 46. .52 1SG2942
ATOM 2942 CD2 LEU 379 77. .189 35. .604 21, .222 1. .00 46. .52 1SG2943
ATOM 2943 CDl LEU 379 75. ,493 36. .203 23, .051 1. ,00 46. .52 1SG2944
ATOM 2944 C LEU 379 75. .102 38. .362 18, .631 1. .00 46. .52 1SG2945
ATOM 2945 O LEU 379 75. ,158 39. .559 18, .350 1. .00 46. .52 1SG2946
ATOM 2946 N ASN 380 74. .118 37. .547 18, .194 1. .00 45, .20 1SG2947
ATOM 2947 CA ASN 380 73. .005 37. .964 17, .392 1. .00 45, .20 1SG2948
ATOM 2948 CB ASN 380 72, .776 37, .066 16, .166 1. .00 45, .20 1SG2949
ATOM 2949 CG ASN 380 73. .956 37, .278 15, .226 1. .00 45, .20 1SG2950
ATOM 2950 ODl ASN 380 74. .995 36, .632 15 .364 1. .00 45, .20 1SG2951
ATOM 2951 ND2 ASN 380 73, .798 38 .206 14 .246 1. .00 45 .20 1SG2952
ATOM 2952 C ASN 380 71, .793 37, .891 18 .275 1. .00 45 .20 1SG2953
ATOM 2953 O ASN 380 71. .914 37 .936 19 .499 1. .00 45 .20 1SG2954
ATOM 2954 N ARG 381 70. .584 37 .816 17 .679 1, .00 45 .88 1SG2955
ATOM 2955 CA ARG 381 69. .385 37, .796 18, .474 1. .00 45, .88 1SG2956
ATOM 2956 CB ARG 381 68. .075 37, .843 17 .653 1. .00 45, .88 1SG2957
ATOM 2957 CG ARG 381 67. .884 39, .149 16 .867 1. .00 45, .88 1SG2958
ATOM 2958 CD ARG 381 66, .679 39, .173 15 .913 1. .00 45, .88 1SG2959
ATOM 2959 NE ARG 381 65. .678 40, .156 16 .424 1. .00 45, .88 1SG2960
ATOM 2960 CZ ARG 381 64. .998 40, .944 15 .535 1, .00 45 .88 1SG2961
ATOM 2961 NHl ARG 381 65, .214 40, .792 14 .195 1. .00 45 .88 1SG2962
ATOM 2962 NH2 ARG 381 64, .117 41, .889 15 .973 1, .00 45 .88 1SG2963
ATOM 2963 C ARG 381 69, .380 36 .535 19 .277 1, .00 45 .88 1SG2964
ATOM 2964 0 ARG 381 69, .851 35 .490 18 .829 1. .00 45 .88 1SG2965
ATOM 2965 N PHE 382 68, .859 36 .606 20 .516 1, .00 48 .50 1SG2966
ATOM 2966 CA PHE 382 68 .835 35 .418 21 .312 1. .00 48 .50 1SG2967
ATOM 2967 CB PHE 382 69 .639 35 .500 22 .624 1. .00 48 .50 1SG2968
ATOM 2968 CG PHE 382 69 .678 36 .908 23 .099 1. .00 48 .50 1SG2969
ATOM 2969 CDl PHE 382 70 .554 37 .773 22 .483 1. .00 48 .50 1SG2970
ATOM 2970 CD2 PHE 382 68 .904 37 .361 24 .140 1, .00 48 .50 1SG2971
ATOM 2971 CE1 PHE 382 70 .652 39 .083 22 .876 1, .00 48 .50 1SG2972
ATOM 2972 CE2 PHE 382 68 .998 38 .674 24 .539 1, .00 48 .50 1SG2973
ATOM 2973 CZ PHE 382 69 .869 39 .531 23 .908 1, .00 48 .50 1SG2974
ATOM 2974 C PHE 382 67 .457 34 .868 21 .463 1 .00 48 .50 1SG2975
ATOM 2975 O PHE 382 66 .471 35 .595 21 .566 1, .00 48 .50 1SG2976
ATOM 2976 N ARG 383 67 .389 33 .519 21 .415 1, .00 48 .48 1SG2977
ATOM 2977 CA ARG 383 66 .172 32 .766 21 .473 1, .00 48 .48 1SG2978
ATOM 2978 CB ARG 383 66, .192 31. .456 20 .663 1. .00 48, .48 1SG2979
ATOM 2979 CG ARG 383 65, .909 31. .571 19 .165 1. .00 48, .48 1SG2980
ATOM 2980 CD ARG 383 64, .436 31 .327 18 .823 1. .00 48, .48 1SG2981
ATOM 2981 NE ARG 383 64, .360 30, .938 17 .386 1. .00 48, .48 1SG2982
ATOM 2982 CZ ARG 383 64 .566 29 .635 17 .033 1. .00 48, .48 1SG2983
ATOM 2983 NHl ARG 383 64 .862 28 .707 17 .988 1, .00 48, .48 1SG2984
ATOM 2984 NH2 ARG 383 64 .483 29, .252 15 .724 1, .00 48, .48 1SG2985
ATOM 2985 C ARG 383 65 .973 32 .318 22 .872 1. .00 48 .48 1SG2986
ATOM 2986 0 ARG 383 66 .904 31 .866 23 .537 1. .00 48 .48 1SG2987
ATOM 2987 N LEU 384 64 .723 32 .427 23 .344 1. .00 47, .40 1SG2988
ATOM 2988 CA LEU 384 64 .405 32 .028 24 .674 1. .00 47 .40 1SG2989
ATOM 2989 CB LEU 384 63 .704 33 .164 25 .428 1. .00 47, .40 1SG2990 ATOM 2990 CG LEU 384 64,.548 34..454 25,.389 1..00 47.40 1SG2991
ATOM 2991 CD2 LEU 384 65. .969 34, .212 25. .901 1. ,00 47, .40 1SG2992
ATOM 2992 CDl LEU 384 63. .879 35, .607 26. .130 1. .00 47 .40 1SG2993
ATOM 2993 C LEU 384 63, .461 30 .875 24, .562 1. .00 47 .40 1SG2994
ATOM 2994 O LEU 384 62. .730 30, .747 23, .580 1. .00 47, .40 1SG2995
ATOM 2995 N ALA 385 63. .495 29, .976 25. .561 1. .00 43 .33 1SG2996
ATOM 2996 CA ALA 385 62. .597 28 .860 25. .593 1. .00 43 .33 1SG2997
ATOM 2997 CB ALA 385 63. .206 27 .549 25, .067 1. .00 43, .33 1SG2998
ATOM 2998 C ALA 385 62. .299 28, .646 27, .038 1. .00 43-, .33 1SG2999
ATOM 2999 o ALA 385 63, .142 28, .914 27. .892 1. .00 43 .33 1SG3000
ATOM 3000 N LEU 386 61, .083 28, .166 27. .356 1. .00 40 .43 1SG3001
ATOM 3001 CA LEU 386 60. .741 27, .974 28. .734 1. .00 40, .43 1SG3002
ATOM 3002 CB LEU 386 59. .328 28, .495 29, .053 1. .00 40 .43 1SG3003
ATOM 3003 CG LEU 386 58, .900 28 .327 30, .519 1. .00 40 .43 1SG3004
ATOM 3004 CD2 LEU 386 57. .391 28, .564 30, .691 1. .00 40, .43 1SG3005
ATOM 3005 CDl LEU 386 59, .752 29, .211 31, .443 1. .00 40 .43 1SG3006
ATOM 3006 C LEU 386 60, .754 26, .499 29, .009 1. .00 40 .43 1SG3007
ATOM 3007 O LEU 386 59, .922 25 .758 28 .489 1. .00 40 .43 1SG3008
ATOM 3008 N PRO 387 61. .756 26, .048 29, .725 1. .00 38 .31 1SG3009
ATOM 3009 CA PRO 387 61. .823 24, .666 30, .138 1. .00 38 .31 1SG3010
ATOM 3010 CD PRO 387 63. .080 26 .613 29, .547 1. .00 38 .31 1SG3011
ATOM 3011 CB PRO 387 63. .298 24. .374 30, .431 1. .00 38 .31 1SG3012
ATOM 3012 CG PRO 387 63 , .975 25, .756 30, .452 1. .00 38 .31 1SG3013
ATOM 3013 C PRO 387 60. .893 24, .247 31, .241 1. .00 38 .31 1SG3014
ATOM 3014 O PRO 387 60 .350 23 .146 31 .162 1. .00 38 .31 1SG3015
ATOM 3015 N GLU 388 60. .702 25, .088 32, .280 1. .00 40 .89 1SG3016
ATOM 3016 CA GLU 388 59. .829 24, .732 33, .365 1. .00 40 .89 1SG3017
ATOM 3017 CB GLU 388 60. .338 23 .566 34, .234 1. .00 40 .89 1SG3018
ATOM 3018 CG GLU 388 61. .652 23, .851 34. .966 1. ,00 40, .89 1SG3019
ATOM 3019 CD GLU 388 62. .011 22, .615 35. .782 1. .00 40, .89 1SG3020
ATOM 3020 OEl GLU 388 61. .176 21, .673 35. .820 1. .00 40 .89 1SG3021
ATOM 3021 OE2 GLU 388 63. .121 22 .595 36. .378 1. .00 40 .89 1SG3022
ATOM 3022 C GLU 388 59. .724 25, .931 34. .252 1. ,00 40, .89 1SG3023
ATOM 3023 O GLU 388 60, .662 26. .720 34. .346 1. .00 40, .89 1SG3024
ATOM 3024 N SER 389 58, .564 26 .107 34. .921 1. .00 45, .75 1SG3025
ATOM 3025 CA SER 389 58. .441 27. .251 35. .771 1. ,00 45, .75 1SG3026
ATOM 3026 CB SER 389 57. .711 28. .426 35. .097 1. ,00 45, .75 1SG3027
ATOM 3027 OG SER 389 57, .623 29. .527 35. .989 1. .00 45, .75 1SG3028
ATOM 3028 C SER 389 57, .648 26 .865 36. .980 1. .00 45 .75 1SG3029
ATOM 3029 O SER 389 56. .621 26. .197 36. .881 1. .00 45, .75 1SG3030
ATOM 3030 N ASN 390 58, .141 27. .263 38. .169 1. ,00 51, .03 1SG3031
ATOM 3031 CA ASN 390 57, .441 27. .039 39. .400 1. ,00 51, .03 1SG3032
ATOM 3032 CB ASN 390 58. .310 27. .253 40. .650 1. ,00 51. .03 1SG3033
ATOM 3033 CG ASN 390 59. .289 26 , .091 40. .699 1. ,00 51. .03 1SG3034
ATOM 3034 ODl ASN 390 59. .262 25. .221 39. .830 1. ,00 51, .03 1SG3035
ATOM 3035 ND2 ASN 390 60, .170 26. .065 41. .733 1. .00 51, .03 1SG3036
ATOM 3036 C ASN 390 56. .302 28. .009 39. .453 1. .00 51. .03 1SG3037
ATOM 3037 O ASN 390 55, .263 27. .746 40. .055 1. ,00 51. .03 1SG3038
ATOM 3038 N ARG 391 56, .523 29, .179 38. .829 1. ,00 58. .25 1SG3039
ATOM 3039 CA ARG 391 55. .660 30. .330 38. .774 1. 00 58. .25 1SG3040
ATOM 3040 CB ARG 391 56. .362 31. .515 38. .085 1. ,00 58. .25 1SG3041
ATOM 3041 CG ARG 391 55. .483 32. .747 37. .871 1. ,00 58. .25 1SG3042
ATOM 3042 CD ARG 391 54. .743 32. .738 36. .529 1. ,00 58. .25 1SG3043
ATOM 3043 NE ARG 391 53. ,967 34. .007 36. .436 1. 00 58. .25 1SG3044
ATOM 3044 CZ ARG 391 53. .169 34. .255 35. .357 1. 00 58. .25 1SG3045
ATOM 3045 NHl ARG 391 53. .040 33. .325 34. ,366 1. 00 58. .25 1SG3046
ATOM 3046 NH2 ARG 391 52. .485 35. .433 35. 276 1. 00 58. .25 1SG3047 ATOM 3047 C ARG 391 54.392 30,.073 38..022 1..00 58,.25 1SG3048
ATOM 3048 O ARG 391 53 .390 30, .710 38. .329 1. .00 58 .25 1SG3049
ATOM 3049 N SER 392 54 .431 29, .221 36. .975 1. .00 56 .92 1SG3050
ATOM 3050 CA SER 392 53 .324 28 .838 36 .129 1. .00 56 .92 1SG3051
ATOM 3051 CB SER 392 51 .939 29, .461 36 .408 1. .00 56 .92 1SG3052
ATOM 3052 OG SER 392 51 .449 29 .020 37 .666 1, .00 56 .92 1SG3053
ATOM 3053 C SER 392 53 .712 29, .250 34 .753 1. .00 56 .92 1SG3054
ATOM 3054 O SER 392 54 .767 29, .851 34 .561 1. .00 56 .92 1SG3055
ATOM 3055 N ASN 393 52 .862 28, .939 33 .758 1, .00 55 .05 1SG3056
ATOM 3056 CA ASN 393 53 .187 29, .280 32 .405 1, .00 55 .05 1SG3057
ATOM 3057 CB ASN 393 52 .254 28, .632 31 .366 1. .00 55 .05 1SG3058
ATOM 3058 CG ASN 393 52 .524 27, .135 31 .338 1. .00 55 .05 1SG3059
ATOM 3059 ODl ASN 393 51 .702 26, .334 31 .780 1. .00 55, .05 1SG3060
ATOM 3060 ND2 ASN 393 53 .710 26, .742 30 .800 1. .00 55. .05 1SG3061
ATOM 3061 C ASN 393 53 .061 30, .760 32 .240 1. .00 55 .05 1SG3062
ATOM 3062 O ASN 393 52 .121 31, .379 32 .736 1. .00 55 .05 1SG3063
ATOM 3063 N ILE 394 54 .038 31, .361 31 .533 1. .00 52 .36 1SG3064
ATOM 3064 CA ILE 394 54 .041 32, .765 31 .252 1. .00 52 .36 1SG3065
ATOM 3065 CB ILE 394 54 .891 33, .571 32 .191 1, .00 52 .36 1SG3066
ATOM 3066 CG2 ILE 394 56 .354 33, .126 32 .011 1. .00 52 .36 1SG3067
ATOM 3067 CGI ILE 394 . 54 .653 35, .074 31 .959 1, .00 52 .36 1SG3068
ATOM 3068 CDl ILE 394 53 .241 35, .531 32 .321 1, .00 52 .36 1SG3069
ATOM 3069 C ILE 394 54 .619 32, .946 29 .888 1. .00 52 .36 1SG3070
ATOM 3070 O ILE 394 55 .217 32, .029 29 .326 1. .00 52 .36 1SG3071
ATOM 3071 N GLU 395 54 .440 34, .146 29 .303 1. .00 47 .43 1SG3072
ATOM 3072 CA GLU 395 55 .004 34, .368 28 .006 1. .00 47 .43 1SG3073
ATOM 3073 CB GLU 395 54 .550 35, .692 27 .364 1. .00 47 .43 1SG3074
ATOM 3074 CG GLU 395 53 .040 35, .773 27 .114 1. .00 47 .43 1SG3075
ATOM 3075 CD GLU 395 52 .674 34, .830 25, .976 1. .00 47 .43 1SG3076
ATOM 3076 OEl GLU 395 53 .605 34, .244 25, .363 1. .00 47 .43 1SG3077
ATOM 3077 OE2 GLU 395 51 .452 34, .685 25 .705 1. .00 47. .43 1SG3078
ATOM 3078 C GLU 395 56 .489 34, .437 28 .201 1. .00 47 .43 1SG3079
ATOM 3079 O GLU 395 56 .999 35, .274 28 .942 1. .00 47. .43 1SG3080
ATOM 3080 N VAL 396 57 .224 33, .546 27, .513 1. .00 47. .60 1SG3081
ATOM 3081 CA VAL 396 58 .655 33, .459 27, .614 1. .00 47. .60 1SG3082
ATOM 3082 CB VAL 396 59 .255 32, .312 26, .847 1. .00 47, .60 1SG3083
ATOM 3083 CGI VAL 396 58 .668 31, .002 27, .392 1. .00 47. .60 1SG3084
ATOM 3084 CG2 VAL 396 59 .038 32, .525 25, .342 1. .00 47, .60 1SG3085
ATOM 3085 C VAL 396 59, .245 34, .719 27, .069 1. .00 47, .60 1SG3086
ATOM 3086 O VAL 396 60, .380 35, .069 27, .387 1. .00 47, .60 1SG3087
ATOM 3087 N LEU 397 58, .486 35. .400 26, .191 1. ,00 46. .15 1SG3088
ATOM 3088 CA LEU 397 58, .885 36. .591 25, .493 1. ,00 46. .15 1SG3089
ATOM 3089 CB LEU 397 57. .839 37. .053 24, .464 1. ,00 46. .15 1SG3090
ATOM 3090 CG LEU 397 57. .648 36. .061 23, .303 1. .00 46. .15 1SG3091
ATOM 3091 CD2 LEU 397 56, .793 36. .670 22 , .179 1. ,00 46. .15 1SG3092
ATOM 3092 CDl LEU 397 57, .105 34. .713 23, .805 1. ,00 46. .15 1SG3093
ATOM 3093 C LEU 397 59. .128 37. .741 26. .428 1. ,00 46. .15 1SG3094
ATOM 3094 O LEU 397 59. .933 38. .618 26. .122 1. ,00 46. .15 1SG3095
ATOM 3095 N ARG 398 58. .431 37. .797 27. .577 1. .00 44. .86 1SG3096
ATOM 3096 CA ARG 398 58, .535 38. .925 28. .465 1. ,00 44. .86 1SG3097
ATOM 3097 CB ARG 398 57, .537 38. .848 29. .633 1. 00 44. .86 1SG3098
ATOM 3098 CG ARG 398 56 , .100 38. .973 29. .116 1. .00 44. .86 1SG3099
ATOM 3099 CD ARG 398 55. .017 39. .088 30. .189 1. .00 44. ,86 1SG3100
ATOM 3100 NE ARG 398 53. .718 39. ,223 29. .469 1. 00 44. ,86 1SG3101
ATOM 3101 CZ ARG 398 52. .590 39. ,586 30. .144 1. 00 44. ,86 1SG3102
ATOM 3102 NHl ARG 398 52. ,648 39. ,839 31. .485 1. 00 44. .86 1SG3103
ATOM 3103 NH2 ARG 398 51. .402 39. .695 29. .480 1. 00 44. ,86 1SG3104 ATOM 3104 C ARG 398 59..940 39..096 28..976 1..00 44..86 1SG3105
ATOM 3105 O ARG 398 60. .356 40. .214 29, .272 1. .00 44. .86 1SG3106
ATOM 3106 N PHE 399 60. ,688 37. .990 29. .122 1. .00 47. .37 1SG3107
ATOM 3107 CA PHE 399 62. ,053 37. .939 29. .587 1. .00 47. .37 1SG3108
ATOM 3108 CB PHE 399 62. .535 36. .510 29. .892 1. .00 47, .37 1SG3109
ATOM 3109 CG PHE 399 61. .833 36. .039 31, .119 1. .00 47. .37 1SG3110
ATOM 3110 CDl PHE 399 60. .544 35. .565 31, .052 1. .00 47. .37 1SG3111
ATOM 3111 CD2 PHE 399 62. .473 36, .067 32, .337 1, .00 47. .37 1SG3112
ATOM 3112 CE1 PHE 399 59. .901 35. .128 32 .187 1. .00 47. .37 1SG3113
ATOM 3113 CE2 PHE 399 61. .835 35, .631 33, .474 1. .00 47. .37 1SG3114
ATOM 3114 CZ PHE 399 60. .547 35, .161 33 .399 1, .00 47. .37 1SG3115
ATOM 3115 C PHE 399 63. .008 38. .512 28. .579 1. .00 47. .37 1SG3116
ATOM 3116 O PHE 399 64. ,125 38. .883 28. .926 1. .00 47. .37 1SG3117
ATOM 3117 N GLU 400 62. .634 38. .555 27, .290 1. .00 49. .39 1SG3118
ATOM 3118 CA GLU 400 63. .572 38. .911 26, .259 1. .00 49. .39 1SG3119
ATOM 3119 CB GLU 400 62. .927 38. .944 24, .864 1. .00 49. .39 1SG3120
ATOM 3120 CG GLU 400 62. .507 37. .550 24, .391 1. .00 49. .39 1SG3121
ATOM 3121 CD GLU 400 61. .941 37. .650 22, .986 1. .00 49 .39 1SG3122
ATOM 3122 OEl GLU 400 61, .247 38. .660 22 .695 1, .00 49 .39 1SG3123
ATOM 3123 OE2 GLU 400 62. .188 36 .705 22 .190 1 .00 49 .39 1SG3124
ATOM 3124 C GLU 400 64. .238 40, .231 26, .517 1, .00 49, .39 1SG3125
ATOM 3125 O GLU 400 65. .444 40, .350 26, .304 1. .00 49, .39 1SG3126
ATOM 3126 N ASN 401 63. .507 41, .260 26, .975 1, .00 52 .08 1SG3127
ATOM 3127 CA ASN 401 64. .161 42, .521 27, .190 1, .00 52. .08 1SG3128
ATOM 3128 CB ASN 401 63. .173 43, .653 27, .535 1, .00 52 .08 1SG3129
ATOM 3129 CG ASN 401 62. .276 43, .206 28 .677 1, .00 52 .08 1SG3130
ATOM 3130 ODl ASN 401 62, .559 43, .416 29 .855 1, .00 52 .08 1SG3131
ATOM 3131 ND2 ASN 401 61, .133 42 .569 28 .309 1 .00 52 .08 1SG3132
ATOM 3132 C ASN 401 65, .221 42 .404 28 .249 1 .00 52 .08 1SG3133
ATOM 3133 O ASN 401 66. .325 42. .920 28, .074 1. .00 52. .08 1SG3134
ATOM 3134 N ILE 402 64. .939 41, .728 29, .379 1, .00 53, .52 1SG3135
ATOM 3135 CA ILE 402 65. .951 41, .622 30, .391 1, .00 53 .52 1SG3136
ATOM 3136 CB ILE 402 65. .483 41, .133 31. .725 1, .00 53 .52 1SG3137
ATOM 3137 CG2 ILE 402 64, .471 42, .153 32. .249 1, .00 53 .52 1SG3138
ATOM 3138 CGI ILE 402 64. .934 39, .714 31. .676 1, .00 53 .52 1SG3139
ATOM 3139 CDl ILE 402 64. .717 39. .178 33. .085 1, .00 53 .52 1SG3140
ATOM 3140 C ILE 402 67, .087 40 .779 29 .904 1 .00 53 .52 1SG3141
ATOM 3141 O ILE 402 68. .248 41 .093 30 .159 1 .00 53 .52 1SG3142
ATOM 3142 N LEU 403 66. .787 39. .685 29, .181 1, .00 50, .97 1SG3143
ATOM 3143 CA LEU 403 67. .812 38. .819 28, .668 1, .00 50, .97 1SG3144
ATOM 3144 CB LEU 403 67. .263 37, .554 27, .981 1, .00 50, .97 1SG3145
ATOM 3145 CG LEU 403 66. .807 36, .455 28, .969 1. .00 50, .97 1SG3146
ATOM 3146 CD2 LEU 403 65. .748 36, .949 29, .963 1, .00 50, .97 1SG3147
ATOM 3147 CDl LEU 403 68. .013 35, .846 29, .699 1, .00 50, .97 1SG3148
ATOM 3148 C LEU 403 68. .665 39, .587 27, .707 1, .00 50 .97 1SG3149
ATOM 3149 0 LEU 403 69. .864 39, .338 27 .596 1 .00 50 .97 1SG3150
ATOM 3150 N SER 404 68. .069 40, .536 26 .968 1 .00 49 .29 1SG3151
ATOM 3151 CA SER 404 68. .804 41. .300 26, .002 1, .00 49. .29 1SG3152
ATOM 3152 CB SER 404 67. .914 42. .263 25. .196 1, .00 49. .29 1SG3153
ATOM 3153 OG SER 404 66. .979 41. .530 24. .419 1. .00 49. .29 1SG3154
ATOM 3154 C SER 404 69. .839 42. .126 26. .687 1, .00 49. .29 1SG3155
ATOM 3155 0 SER 404 70. .920 42, .326 26. .143 1, .00 49. .29 1SG3156
ATOM 3156 N SER 405 69. .511 42, .691 27, .862 1, .00 48. .84 1SG3157
ATOM 3157 CA SER 405 70, .464 43, .494 28, .576 1, .00 48. .84 1SG3158
ATOM 3158 CB SER 405 69. .803 44, .404 29, .623 1, .00 48. .84 1SG3159
ATOM 3159 OG SER 405 70, .795 45. .169 30, .291 1, .00 48. .84 1SG3160
ATOM 3160 C SER 405 71. .479 42. .659 29. .306 1. .00 48. .84 1SG3161 ATOM 3161 O SER 405 72..684 42,.895 29..208 1..00 48..84 1SG3162
ATOM 3162 N ILE 406 71. .010 41, .641 30. .058 1. .00 54, .51 1SG3163
ATOM 3163 CA ILE 406 71. .885 40, .931 30, .949 1. .00 54. .51 1SG3164
ATOM 3164 CB ILE 406 71, .178 39 .818 31, .669 1. .00 54. .51 1SG3165
ATOM 3165 CG2 ILE 406 72, .193 39, .163 32, .623 1. .00 54, .51 1SG3166
ATOM 3166 CGI ILE 406 69. .899 40, .329 32, .363 1. .00 54. .51 1SG3167
ATOM 3167 CDl ILE 406 70. .124 41 .446 33 .379 1, .00 54. .51 1SG3168
ATOM 3168 C ILE 406 72. .995 40, .287 30 .186 1. .00 54. .51 1SG3169
ATOM 3169 O ILE 406 74. .166 40, .458 30. .529 1. .00 54 .51 1SG3170
ATOM 3170 N LEU 407 72. .662 39, .544 29 .114 1, .00 62. .46 1SG3171
ATOM 3171 CA LEU 407 73. .696 38, .825 28, .433 1. .00 62. .46 1SG3172
ATOM 3172 CB LEU 407 73. .161 3 .917 27 .314 1. .00 62 .46 1SG3173
ATOM 3173 CG LEU 407 72. .362 36. .713 27 .847 1. .00 62. .46 1SG3174
ATOM 3174 CD2 LEU 407 71. .123 37. .155 28, .634 1. ,00 62, .46 1SG3175
ATOM 3175 CDl LEU 407 73, .260 35. .768 28 .661 1. ,00 62 .46 1SG3176
ATOM 3176 C LEU 407 74, .732 39. .737 27 .836 1. .00 62 .46 1SG3177
ATOM 3177 O LEU 407 75 .920 39 .600 28 .118 1, .00 62 .46 1SG3178
ATOM 3178 N HIS 408 74. .328 40. .728 27, .026 1. .00 71, .23 1SG3179
ATOM 3179 CA HIS 408 75, .309 41. .543 26 .362 1, .00 71, .23 1SG3180
ATOM 3180 NDl HIS 408 74 .993 41 .540 23 .028 1 .00 71 .23 1SG3181
ATOM 3181 CG HIS 408 74. .194 41. .853 24 .106 1, .00 71 .23 1SG3182
ATOM 3182 CB HIS 408 74. .697 42, .529 25 .350 1, .00 71 .23 1SG3183
ATOM 3183 NE2 HIS 408 72. .941 40, .853 22, .517 1. .00 71, .23 1SG3184
ATOM 3184 CD2 HIS 408 72. .944 41, .426 23 .777 1, .00 71 .23 1SG3185
ATOM 3185 CE1 HIS 408 74 .193 40 .944 22 .108 1, .00 71 .23 1SG3186
ATOM 3186 C HIS 408 76. .098 42, .321 27, .355 1. .00 71, .23 1SG3187
ATOM 3187 O HIS 408 77. .308 42. .472 27 .203 1. .00 71 .23 1SG3188
ATOM 3188 N PHE 409 75. .443 42, .871 28, .390 1. .00 81 .17 1SG3189
ATOM 3189 CA PHE 409 76. .229 43 .590 29 .338 1. .00 81 .17 1SG3190
ATOM 3190 CB PHE 409 75, .654 44. .978 29 .664 1 .00 81 .17 1SG3191
ATOM 3191 CG PHE 409 76, .629 45, .672 30, .549 1. .00 81, .17 1SG3192
ATOM 3192 CDl PHE 409 76, .622 45 .457 31 .907 1. .00 81 .17 1SG3193
ATOM 3193 CD2 PHE 409 77, .551 46, .542 30, .014 1. .00 81 .17 1SG3194
ATOM 3194 CE1 PHE 409 77, .525 46, .101 32 .721 1, .00 81 .17 1SG3195
ATOM 3195 CE2 PHE 409 78, .456 47 .188 30 .823 1. .00 81 .17 1SG3196
ATOM 3196 CZ PHE 409 78, .443 46, .968 32, .179 1. .00 81 .17 1SG3197
ATOM 3197 C PHE 409 76. .212 4 .789 30 .594 1, .00 81 .17 1SG3198
ATOM 3198 O PHE 409 75, .353 42 .953 31 .442 1. .00 81 .17 1SG3199
ATOM 3199 N GLY 410 77, .212 41, .944 30, .818 1. .00 81, .72 1SG3200
ATOM 3200 CA GLY 410 77, .220 41 .157 32 .011 1. .00 81 .72 1SG3201
ATOM 3201 C GLY 410 77, .727 39, .791 31, .670 1. .00 81, .72 1SG3202
ATOM 3202 O GLY 410 78 .771 39 .405 32 .189 1. .00 81 .72 1SG3203
ATOM 3203 N VAL 411 77. .030 38, .997 30. .829 1. .00 78. .95 1SG3204
ATOM 3204 CA VAL 411 77. .609 37, .712 30, .544 1. .00 78. .95 1SG3205
ATOM 3205 CB VAL 411 76 .624 36 .637 30, .154 1. .00 78. .95 1SG3206
ATOM 3206 CGI VAL 411 75, .634 36, .453 31, .314 1. .00 78. .95 1SG3207
ATOM 3207 CG2 VAL 411 75, .958 36, .964 28. .819 1. .00 78, .95 1SG3208
ATOM 3208 C VAL 411 78. .720 37. .776 29. .532 1. .00 78. .95 1SG3209
ATOM 3209 O VAL 411 79. .800 37, .234 29, .756 1. .00 78, .95 1SG3210
ATOM 3210 N LEU 412 78 .508 38 .463 28, .392 1. .00 70 .27 1SG3211
ATOM 3211 CA LEU 412 79. .510 38. .438 27. .358 1. .00 70, .27 1SG3212
ATOM 3212 CB LEU 412 79. .112 39. .067 26. .016 1. ,00 70, .27 1SG3213
ATOM 3213 CG LEU 412 78. .181 38. .172 25. .186 1. ,00 70. .27 1SG3214
ATOM 3214 CD2 LEU 412 78. .302 38. .497 23. .691 1. ,00 70. .27 1SG3215
ATOM 3215 CDl LEU 412 76, .749 38. .167 25. .740 1. .00 70. .27 1SG3216
ATOM 3216 C LEU 412 80. .790 39. .081 27. .781 1. 00 70. .27 1SG3217
ATOM 3217 O LEU 412 81. .852 38. .583 27. .410 1. .00 70. .27 1SG3218 ATOM 3218 N PRO 413 80..776 40,.150 28..523 1..00 57,.29 1SG3219
ATOM 3219 CA PRO 413 82. .030 40, .772 28. .840 1. .00 57. .29 1SG3220
ATOM 3220 CD PRO 413 79. .688 41, .113 28. .488 1. .00 57, .29 1SG3221
ATOM 3221 CB PRO 413 81. .669 42, .082 29, .534 1. .00 57, .29 1SG3222
ATOM 3222 CG PRO 413 80. .320 42, .459 28. .888 1. .00 57, .29 1SG3223
ATOM 3223 C PRO 413 82. .966 39, .883 29. .595 1. .00 57. .29 1SG3224
ATOM 3224 O PRO 413 84. .174 39, .990 29. .390 1. .00 57 .29 1SG3225
ATOM 3225 N LEU 414 82, .446 39 .014 30 .481 1 .00 47, .37 1SG3226
ATOM 3226 CA LEU 414 83. .309 38. .146 31, .230 1 .00 47 .37 1SG3227
ATOM 3227 CB LEU 414 82. .570 37, .429 32, .385 1, .00 47, .37 1SG3228
ATOM 3228 CG LEU 414 81. .411 36, .488 31, .988 1, .00 47, .37 1SG3229
ATOM 3229 CD2 LEU 414 80. .424 36 .305 3 .152 1. .00 47 .37 1SG3230
ATOM 3230 CDl LEU 414 81. .913 35, .149 31, .425 1. .00 47, .37 1SG3231
ATOM 3231 C LEU 414 83. .935 37, .144 30. ,308 1, .00 47, .37 1SG3232
ATOM 3232 O LEU 414 85. .121 36, .836 30, ,428 1. .00 47, .37 1SG3233
ATOM 3233 N ALA 415 83. .144 36, .610 29, .358 1, .00 38 .83 1SG3234
ATOM 3234 CA ALA 415 83. .625 35 .603 28 .454 1 .00 38 .83 1SG3235
ATOM 3235 CB ALA 415 82. .523 35, .076 27. .519 1. .00 38 .83 1SG3236
ATOM 3236 C ALA 415 84. .701 36, .174 27. .591 1, .00 38 .83 1SG3237
ATOM 3237 0 ALA 415 85. .744 35, .555 27, .395 1, .00 38 .83 1SG3238
ATOM 3238 N ASN 416 84, .479 37 .396 27 .081 1 .00 35 .53 1SG3239
ATOM 3239 CA ASN 416 85. .394 38. .023 26, ,173 1. .00 35, .53 1SG3240
ATOM 3240 CB ASN 416 84. .887 39. .385 25, .671 1, .00 35, .53 1SG3241
ATOM 3241 CG ASN 416 83. .684 39. .105 24. .780 1. .00 35, .53 1SG3242
ATOM 3242 ODl ASN 416 83. .677 38, .132 24 .028 1. .00 35 .53 1SG3243
ATOM 3243 ND2 ASN 416 82. .637 39, .968 24. .871 1, .00 35 .53 1SG3244
ATOM 3244 C ASN 416 86. .698 38, .225 26. .867 1. .00 35, .53 1SG3245
ATOM 3245 0 ASN 416 87. .742 38 .241 26 .223 1. .00 35 .53 1SG3246
ATOM 3246 N ALA 417 86. .677 38, .407 28. .200 1, .00 34 .12 1SG3247
ATOM 3247 CA ALA 417 87. .900 38, .635 28. .916 1, .00 34 .12 1SG3248
ATOM 3248 CB ALA 417 87. .675 38, .823 30, .427 1. .00 34, .12 1SG3249
ATOM 3249 C ALA 417 88. .808 37, .453 28, .745 1, .00 34 .12 1SG3250
ATOM 3250 0 ALA 417 90. .009 37, .617 28, .540 1. .00 34 .12 1SG3251
ATOM 3251 N LYS 418 88. .259 36, .228 28 .840 1. .00 34 .77 1SG3252
ATOM 3252 CA LYS 418 89, .036 35, .027 28, .703 1, .00 34 .77 1SG3253
ATOM 3253 CB LYS 418 88, .170 33, .777 28, .911 1, .00 34, .77 1SG3254
ATOM 3254 CG LYS 418 88, .928 32 .458 28 .780 1, .00 34 .77 1SG3255
ATOM 3255 CD LYS 418 89, .861 32, .162 29 .951 1, .00 34 .77 1SG3256
ATOM 3256 CE LYS 418 90. .484 30, .768 29. .866 1. .00 34, .77 1SG3257
ATOM 3257 NZ LYS 418 91. .164 30, .442 31. .137 1. .00 34, .77 1SG3258
ATOM 3258 C LYS 418 89. .580 34 .941 27. .310 1. .00 34 .77 1SG3259
ATOM 3259 0 LYS 418 90. .765 34, .682 27, .103 1, .00 34, .77 1SG3260
ATOM 3260 N LEU 419 88. .711 35, .174 26. .309 1. .00 35, .47 1SG3261
ATOM 3261 CA LEU 419 89, .104 35, .076 24. .933 1. .00 35, .47 1SG3262
ATOM 3262 CB LEU 419 87, .939 35, .250 23. .943 1. .00 35, .47 1SG3263
ATOM 3263 CG LEU 419 86, .966 34, .053 23. .935 1, .00 35 .47 1SG3264
ATOM 3264 CD2 LEU 419 85. .996 34. .129 22. .749 1. ,00 35. .47 1SG3265
ATOM 3265 CDl LEU 419 86. .238 33. .895 25. .275 1. .00 35. .47 1SG3266
ATOM 3266 C LEU 419 90. .138 36. .117 24. .644 1. .00 35. .47 1SG3267
ATOM 3267 0 LEU 419 91. .069 35, .881 23, .877 1. .00 35, .47 1SG3268
ATOM 3268 N GLN 420 89. .983 37, .309 25, .246 1, .00 35 .03 1SG3269
ATOM 3269 CA GLN 420 90. ,903 38. .397 25. .082 1. .00 35, .03 1SG3270
ATOM 3270 CB GLN 420 90. .434 39. .692 25. .768 1. .00 35, .03 1SG3271
ATOM 3271 CG GLN 420 89. .247 40. .348 25. .064 1. .00 35, .03 1SG3272
ATOM 3272 CD GLN 420 89, .767 40. .915 23. .751 1. .00 35, .03 1SG3273
ATOM 3273 OEl GLN 420 90. .743 41. ,664 23. .729 1. .00 35. ,03 1SG3274
ATOM 3274 NE2 GLN 420 89. ,108 40. .539 22. .622 1. .00 35. .03 1SG3275 ATOM 3275 C GLN 420 92..213 38..009 25..689 1.,00 35.03 1SG3276
ATOM 3276 O GLN 420 93. .267 38. .404 25. 196 1. ,00 35. 03 1SG3277
ATOM 3277 N GLN 421 92, .180 37, .237 26. .794 1. .00 35. .94 1SG3278
ATOM 3278 CA GLN 421 93. .399 36. .823 27. .427 1. .00 35. .94 1SG3279
ATOM 3279 CB GLN 421 93. .147 35. .912 28. .643 1. .00 35. .94 1SG3280
ATOM 3280 CG GLN 421 92, .403 36. .611 29. .785 1. .00 35. .94 1SG3281
ATOM 3281 CD GLN 421 92, .203 35, .613 30. .918 1. .00 35. ,94 1SG3282
ATOM 3282 OEl GLN 421 91. .795 35, .983 32. ,018 1. .00 35. ,94 1SG3283
ATOM 3283 NE2 GLN 421 92. .492 34. .312 30. .646 1. .00 35. ,94 1SG3284
ATOM 3284 C GLN 421 94. .125 36. .026 26. .398 1. .00 35. .94 1SG3285
ATOM 3285 O GLN 421 95. .325 36. .194 26. .188 1. .00 35. .94 1SG3286
ATOM 3286 N GLY 422 93. .377 35. .149 25. .705 1. .00 38. ,71 1SG3287
ATOM 3287 CA GLY 422 93. .922 34. .408 24. ,611 1. .00 38. ,71 1SG3288
ATOM 3288 C GLY 422 94 .523 33. .131 25. .088 1. .00 38. .71 1SG3289
ATOM 3289 O GLY 422 94. .509 32. .808 26. .277 1. .00 38. .71 1SG3290
ATOM 3290 N PHE 423 95. .063 32, .370 24. ,111 1. .00 45. .07 1SG3291
ATOM 3291 CA PHE 423 95. .686 31, .109 24. ,357 1. .00 45. ,07 1SG3292
ATOM 3292 CB PHE 423 94 .960 29 .948 23. .652 1. .00 45. .07 1SG3293
ATOM 3293 CG PHE 423 93 .530 30, .023 24. .082 1. .00 45. .07 1SG3294
ATOM 3294 CDl PHE 423 93. .153 29, .674 25. .358 1. .00 45. .07 1SG3295
ATOM 3295 CD2 PHE 423 92 .555 30 .435 23. .201 1. .00 45. .07 1SG3296
ATOM 3296 CE1 PHE 423 91 .834 29 .746 25. .746 1, .00 45. .07 1SG3297
ATOM 3297 CE2 PHE 423 91 .234 30, .509 23. .584 1, .00 45. .07 1SG3298
ATOM 3298 CZ PHE 423 90. .868 30, .165 24. .862 1, .00 45. .07 1SG3299
ATOM 3299 C PHE 423 97 .076 31 .217 23. .801 1 .00 45, .07 1SG3300
ATOM 3300 O PHE 423 97 .310 31 .931 22, .826 1, .00 45. .07 1SG3301
ATOM 3301 N PRO 424 98. .021 30 .551 24 , .410 1, .00 51. .77 1SG3302
ATOM 3302 CA PRO 424 99. .371 30, .645 23. .920 1, .00 51. .77 1SG3303
ATOM 3303 CD PRO 424 97 .994 30 .407 25. .859 1 .00 51, .77 1SG3304
ATOM 3304 CB PRO 424 100 .263 30 .092 25, .029 1, .00 51. .77 1SG3305
ATOM 3305 CG PRO 424 99 .469 30 .404 26, .309 1, .00 51. .77 1SG3306
ATOM 3306 C PRO 424 99. .568 29, .966 22. .604 1, .00 51. .77 1SG3307
ATOM 3307 O PRO 424 98 .942 28 .934 22. .366 1 .00 51. .77 1SG3308
ATOM 3308 N LEU 425 100 .448 30 .518 21. .741 1, .00 58. .96 1SG3309
ATOM 3309 CA LEU 425 100. .701 29, .899 20. .470 1, .00 58. .96 1SG3310
ATOM 3310 CB LEU 425 100. .733 30, .870 19. .278 1, .00 58. .96 1SG3311
ATOM 3311 CG LEU 425 99 .339 31 .459 18, .993 1 .00 58. .96 1SG3312
ATOM 3312 CD2 LEU 425 98 .274 30 .355 18. .957 1, .00 58. .96 1SG3313
ATOM 3313 CDl LEU 425 99 .318 32 .322 17. .728 1, .00 58. .96 1SG3314
ATOM 3314 C LEU 425 102 .014 29 .186 20. .540 1 .00 58. .96 1SG3315
ATOM 3315 O LEU 425 102 .904 29 .582 21. .287 1 .00 58, .96 1SG3316
ATOM 3316 N PRO 426 102 .120 28 .080 19. .849 1, .00 60, .75 1SG3317
ATOM 3317 CA PRO 426 103. .339 27, .311 19. .844 1, .00 60. .75 1SG3318
ATOM 3318 CD PRO 426 101 .313 27 .836 18. .664 1 .00 60, .75 1SG3319
ATOM 3319 CB PRO 426 103 .088 26 .191 18, .838 1, .00 60, .75 1SG3320
ATOM 3320 CG PRO 426 102 .133 26 .844 17. .821 1, .00 60. .75 1SG3321
ATOM 3321 C PRO 426 104, .506 28, .116 19. .362 1, .00 60. .75 1SG3322
ATOM 3322 O PRO 426 104 .858 27 .957 18, .195 1 .00 60, .75 1SG3323
ATOM 3323 N ASN 427 105 .192 28 .902 20, .212 1, .00 58, .21 1SG3324
ATOM 3324 CA ASN 427 106 .328 29 .595 19, .677 1, .00 58. .21 1SG3325
ATOM 3325 CB ASN 427 106, .148 31, .119 19. .507 1, .00 58. .21 1SG3326
ATOM 3326 CG ASN 427 105 .977 31 .773 20. .866 1, .00 58. .21 1SG3327
ATOM 3327 ODl ASN 427 106 .756 32 .650 21. .238 1, .00 58. .21 1SG3328
ATOM 3328 ND2 ASN 427 104, .930 31, .346 21. .619 1, .00 58. .21 1SG3329
ATOM 3329 C ASN 427 107 .461 29 .342 20 .612 1, .00 58, .21 1SG3330
ATOM 3330 O ASN 427 107 .279 29 .220 21, .822 1, .00 58. .21 1SG3331
ATOM 3331 N PRO 428 108 .628 29, .233 20. .049 1. .00 54. .12 1SG3332 ATOM 3332 CA PRO 428 109.796 29.003 20.848 1,.00 54..12 1SG3333
ATOM 3333 CD PRO 428 108. .756 28 .625 18 .733 1, .00 54 .12 1SG3334
ATOM 3334 CB PRO 428 110, .893 28 .565 19 .885 1, .00 54 .12 1SG3335
ATOM 3335 CG PRO 428 110. .115 27 .903 18 .740 1, .00 54 .12 1SG3336
ATOM 3336 C PRO 428 110. .118 30 .256 21 .581 1, .00 54 .12 1SG3337
ATOM 3337 O PRO 428 109. .490 31 .279 21 .320 1, .00 54 .12 1SG3338
ATOM 3338 N HIS 429 111. .077. 30 .186 22 .517 1, .00 46 .69 1SG3339
ATOM 3339 CA HIS 429 111. .447 31, .308 23 .323 1, .00 46 .69 1SG3340
ATOM 3340 NDl HIS 429 113, .813 32, .999 24 .980 1, .00 46 .69 1SG3341
ATOM 3341 CG HIS 429 112, .806 32, .118 25 .306 1, .00 46 .69 1SG3342
ATOM 3342 CB HIS 429 112, .418 30, .944 24 .459 1, .00 46 .69 1SG3343
ATOM 3343 NE2 HIS 429 112 .969 33 .687 26 .919 1 .00 46 .69 1SG3344
ATOM 3344 CD2 HIS 429 112 .302 32 .553 26 .493 1 .00 46 .69 1SG3345
ATOM 3345 CE1 HIS 429 113 .868 33 .917 25 .978 1 .00 46 .69 1SG3346
ATOM 3346 C HIS 429 112. .104 32 .353 22 .481 1 .00 46 .69 1SG3347
ATOM 3347 O HIS 429 112 .647 32 .072 21 .413 1 .00 46 .69 1SG3348
ATOM 3348 N LYS 430 112 .028 33 .609 22 .969 1 .00 42 .12 1SG3349
ATOM 3349 CA LYS 430 112, .634 34 .777 22 .395 1 .00 42 .12 1SG3350
ATOM 3350 CB LYS 430 114, .176 34 .789 22 .518 1 .00 42 .12 1SG3351
ATOM 3351 CG LYS 430 114, .921 33 .595 21 .908 1 .00 42 .12 1SG3352
ATOM 3352 CD LYS 430 115, .035 33 .610 20 .381 1 .00 42 .12 1SG3353
ATOM 3353 CE LYS 430 115, .880 32 .463 19 .822 1 .00 42 .12 1SG3354
ATOM 3354 NZ LYS 430 115, .900 32 .517 18 .344 1 .00 42 .12 1SG3355
ATOM 3355 C LYS 430 112, .213 35 .009 20 .977 1 .00 42 .12 1SG3356
ATOM 3356 O LYS 430 113, .014 35 .446 20 .152 1 .00 42 .12 1SG3357
ATOM 3357 N PHE 431 110, .929 34 .762 20 .654 1 .00 38 .10 1SG3358
ATOM 3358 CA PHE 431 110, .481 35 .020 19 .314 1 .00 38 .10 1SG3359
ATOM 3359 CB PHE 431 110, .141 33 .732 18 .540 1 .00 38 .10 1SG3360
ATOM 3360 CG PHE 431 109, .817 34 .086 17, .129 1 .00 38 .10 1SG3361
ATOM 3361 CDl PHE 431 108, .541 34 .445 16, .763 1 .00 38 .10 1SG3362
ATOM 3362 CD2 PHE 431 110, .801 34 .051 16, .168 1 .00 38, .10 1SG3363
ATOM 3363 CE1 PHE 431 108, .253 34, .766 15, .456 1, .00 38, .10 1SG3364
ATOM 3364 CE2 PHE 431 110, .519 34, .372 14, .861 1, .00 38, .10 1SG3365
ATOM 3365 CZ PHE 431 109, .242 34, .730 14, .503 1, .00 38, .10 1SG3366
ATOM 3366 C PHE 431 109, .227 35, .830 19, .418 1, .00 38, .10 1SG3367
ATOM 3367 O PHE 431 108, .438 35, .644 20, .343 1, .00 38, .10 1SG3368
ATOM 3368 N LEU 432 109, .021 36. .774 18, .477 1, .00 34, .77 1SG3369
ATOM 3369 CA LEU 432 107. .831 37, .578 18, .488 1, .00 34, .77 1SG3370
ATOM 3370 CB LEU 432 108. .092 39, .062 18. .797 1. .00 34, .77 1SG3371
ATOM 3371 CG LEU 432 108. .638 39, .306 20. .216 1. .00 34. .77 1SG3372
ATOM 3372 CD2 LEU 432 108. .635 40. .803 20. .565 1. .00 34. .77 1SG3373
ATOM 3373 CDl LEU 432 110. .016 38. .652 20. .405 1. .00 34. .77 1SG3374
ATOM 3374 C LEU 432 107. .235 37. .506 17. .119 1. .00 34. .77 1SG3375
ATOM 3375 O LEU 432 107. .954 37. .410 16. ,125 1. .00 34. .77 1SG3376
ATOM 3376 N PHE 433 105. ,891 37. .548 17. ,030 1. .00 33. .45 1SG3377
ATOM 3377 CA PHE 433 105. ,255 37. .439 15. .748 1. ,00 33. ,45 1SG3378
ATOM 3378 CB PHE 433 104. .096 36. .428 15. .731 1. .00 33. ,45 1SG3379
ATOM 3379 CG PHE 433 104. ,668 35. .092 16. ,057 1. .00 33. .45 1SG3380
ATOM 3380 CDl PHE 433 105. ,272 34. .330 15. ,085 1. .00 33. .45 1SG3381
ATOM 3381 CD2 PHE 433 104. ,597 34. .603 17. ,341 1. ,00 33. .45 1SG3382
ATOM 3382 CE1 PHE 433 105. ,799 33. .097 15. ,390 1. ,00 33. .45 1SG3383
ATOM 3383 CE2 PHE 433 105. ,122 33. .371 17. ,653 1. ,00 33. .45 1SG3384
ATOM 3384 CZ PHE 433 105. 724 32. ,616 16. ,676 1. ,00 33. 45 1SG3385
ATOM 3385 C PHE 433 104. 668 38. ,771 15. 402 1. 00 33. 45 1SG3386
ATOM 3386 O PHE 433 104. 078 39. ,440 16. 249 1. 00 33. 45 1SG3387
ATOM 3387 N VAL 434 104. 824 39. 196 14. 130 1. 00 31. 82 1SG3388
ATOM 3388 CA VAL 434 104. ,290 40. ,463 13. ,724 1. ,00 31. .82 1SG3389 ATOM 3389 CB VAL 434 105,.312 41..564 13.731 1,.00 31.82 1SG3390
ATOM 3390 CGI VAL 434 106, .345 41. .272 12 .630 1. .00 31 .82 1SG3391
ATOM 3391 CG2 VAL 434 104 .597 42, .919 13, .584 1. .00 31 .82 1SG3392
ATOM 3392 C VAL 434 103, .784 40, .325 12, .319 1, .00 31 .82 1SG3393
ATOM 3393 O VAL 434 104, .052 39. .330 11, .647 1, .00 31 .82 1SG3394
ATOM 3394 N ASN 435 103 .027 41. .340 11 .847 1, .00 32 .34 1SG3395
ATOM 3395 CA ASN 435 102 .494 41. .364 10 .513 1. .00 32 .34 1SG3396
ATOM 3396 CB ASN 435 103 .560 41. .615 9 .432 1, .00 32 .34 1SG3397
ATOM 3397 CG ASN 435 104. .071 43, .042 9, .587 1, .00 32 .34 1SG3398
ATOM 3398 ODl ASN 435 105 .263 43, .267 9, .790 1, .00 32 .34 1SG3399
ATOM 3399 ND2 ASN 435 103. .147 44, .035 9 .487 1, .00 32, .34 1SG3400
ATOM 3400 C ASN 435 101 .824 40 .060 10 .221 1 .00 32 .34 1SG3401
ATOM 3401 O ASN 435 102 .245 39 .324 9 .330 1 .00 32 .34 1SG3402
ATOM 3402 N SER 436 100 .755 39 .739 10 .975 1, .00 33 .47 1SG3403
ATOM 3403 CA SER 436 100 .085 38 .485 10 .780 1 .00 33 .47 1SG3404
ATOM 3404 CB SER 436 99 .680 37 .798 12 .095 1 .00 33 .47 1SG3405
ATOM 3405 OG SER 436 99 .024 36 .569 11 .823 1, .00 33 .47 1SG3406
ATOM 3406 C SER 436 98 .833 38 .697 9 .987 1 .00 33 .47 1SG3407
ATOM 3407 O SER 436 98 .246 39 .777 9 .986 1 .00 33 .47 1SG3408
ATOM 3408 N ASP 437 98 .417 37 .641 9 .255 1 .00 34 .58 1SG3409
ATOM 3409 CA ASP 437 97 .218 37 .678 8 .469 1 .00 34 .58 1SG3410
ATOM 3410 CB ASP 437 97 .482 37 .653 6 .953 1 .00 34 .58 1SG3411
ATOM 3411 CG ASP 437 96 .164 37 .901 6 .233 1 .00 34 .58 1SG3412
ATOM 3412 ODl ASP 437 95 .132 38 .092 6 .930 1, .00 34 .58 1SG3413
ATOM 3413 OD2 ASP 437 96 .173 37 .902 4 .973 1. .00 34 .58 1SG3414
ATOM 3414 C ASP 437 96 .441 36, .444 8 .803 1, .00 34 .58 1SG3415
ATOM 3415 O ASP 437 96 .998 35 .348 8 .845 1, .00 34 .58 1SG3416
ATOM 3416 N ILE 438 95. .127 36, .582 9 .074 1, .00 36 .35 1SG3417
ATOM 3417 CA ILE 438 94, .390 35, .395 9 .372 1, .00 36 .35 1SG3418
ATOM 3418 CB ILE 438 93. .713 35, .417 10, .713 1, .00 36 .35 1SG3419
ATOM 3419 CG2 ILE 438 92, .683 36, .560 10, .760 1. .00 36 .35 1SG3420
ATOM 3420 CGI ILE 438 93, .142 34, .024 10, .995 1, .00 36, .35 1SG3421
ATOM 3421 CDl ILE 438 94, .225 32, .948 11. .071 1, .00 36, .35 1SG3422
ATOM 3422 C ILE 438 93, .374 35, .196 8. .293 1. .00 36, .35 1SG3423
ATOM 3423 O ILE 438 92, .486 36, .021 8, .084 1, .00 36, .35 1SG3424
ATOM 3424 N GLU 439 93, .495 34, .076 7. .553 1, .00 37, .00 1SG3425
ATOM 3425 CA GLU 439 92 , .577 33 , .820 6. .487 1. .00 37, .00 1SG3426
ATOM 3426 CB GLU 439 93. .270 33 , .477 5, .157 1. .00 37, .00 1SG3427
ATOM 3427 CG GLU 439 94. .078 34. .639 4. .577 1. .00 37. .00 1SG3428
ATOM 3428 CD GLU 439 94. .710 34. .173 3. .274 1. ,00 37. .00 1SG3429
ATOM 3429 OEl GLU 439 94. .455 33. .005 2. .877 1. .00 37. .00 1SG3430
ATOM 3430 OE2 GLU 439 95. .456 34. .981 2. .657 1. .00 37. .00 1SG3431
ATOM 3431 C GLU 439 91. .773 32. .635 6. .891 1. .00 37. .00 1SG3432
ATOM 3432 O GLU 439 92. .326 31. .588 7. .227 1. ,00 37. .00 1SG3433
ATOM 3433 N VAL 440 90. .433 32. .767 6. .881 1. .00 38. .32 1SG3434
ATOM 3434 CA VAL 440 89. .664 31. .636 7. .283 1. .00 38. ,32 1SG3435
ATOM 3435 CB VAL 440 88. ,289 31. .954 7. .750 1. .00 38. .32 1SG3436
ATOM 3436 CGI VAL 440 87. ,649 30. .604 8. .071 1. ,00 38. .32 1SG3437
ATOM 3437 CG2 VAL 440 88. ,358 32. .918 8. .947 1. ,00 38. .32 1SG3438
ATOM 3438 C VAL 440 89. ,536 30. ,729 6. .106 1. ,00 38. ,32 1SG3439
ATOM 3439 O VAL 440 89. .435 31. ,174 4. .965 1. 00 38. ,32 1SG3440
ATOM 3440 N LEU 441 89. .564 29. ,411 6. .372 1. 00 41. .08 1SG3441
ATOM 3441 CA LEU 441 89. ,457 28. ,422 5. ,343 1. 00 41. .08 1SG3442
ATOM 3442 CB LEU 441 90. .752 27. 632 5. ,088 1. 00 41. 08 1SG3443
ATOM 3443 CG LEU 441 91. 851 28. 464 4. ,407 1. 00 41. 08 1SG3444
ATOM 3444 CD2 LEU 441 92. 209 29. 698 5. ,244 1. 00 41. 08 1SG3445
ATOM 3445 CDl LEU 441 91. .462 28. ,825 2. .964 1. ,00 41. ,08 1SG3446 r~- oo cn o ri CN rθ '<ι< ιn vo r- oo on o ri cN ro i' in vD [- oo cn o ri (N ro ^ι m vo r- co cn o ri cN ro - in vo t- oo cn o ri iN ro co -f in \fi )< jι ιn ιn ιn ιn ιn ιn ιn ιn ιn ιn vo vD VD VD VD Vθ io ιo vD VD t- t- t- c- [- r- t- r- oo oo co co co co co co co co cn cn cn cn
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ATOM 5 CGI ILE 1 97.,757 11..683 21.410 1.00 38.,15 1SG 6
ATOM 6 CDl ILE 1 99. ,128 11. .368 22. ,009 1. ,00 38. ,15 1SG 7
ATOM 7 C ILE 1 97. .918 11. .248 18. ,555 1. .00 38. .15 1SG 8
ATOM 8 0 ILE 1 99. .018 11. .723 18. .278 1. .00 38. .15 1SG 9
ATOM 9 N TYR 2 96. ,772 11. .748 18. ,063 1. .00 37. .97 1SG 10
ATOM 10 CA TYR 2 96. .795 12. .868 17. ,174 1. .00 37. .97 1SG 11
ATOM 11 CB TYR 2 95. .507 13. .025 16. .351 1. ,00 37. ,97 1SG 12
ATOM 12 CG TYR 2 95. .452 11. .790 15. .518 1. .00 37. .97 1SG 13
ATOM 13 CDl TYR 2 96. .290 11, .647 14. .436 1. .00 37. .97 1SG 14
ATOM 14 CD2 TYR 2 94. ,571 10. .776 15. .817 1. ,00 37. .97 1SG 15
ATOM 15 CE1 TYR 2 96. .254 10. .509 13. .666 1. .00 37. .97 1SG 16
ATOM 16 CE2 TYR 2 94. .529 9. .636 15. .050 1. .00 37. .97 1SG 17
ATOM 17 CZ TYR 2 95. .373 9, .501 13. .973 1. .00 37. .97 1SG 18
ATOM 18 OH TYR 2 95. .335 8. .332 13. .185 1. .00 37. .97 1SG 19
ATOM 19 C TYR 2 97. .021 14 , .086 18. .006 1. .00 37. .97 1SG 20
ATOM 20 O TYR 2 96. .509 14, .200 19. .118 1. .00 37. .97 1SG 21
ATOM 21 N PRO 3 97. .845 14 , .970 17. .510 1. .00 38. .90 1SG 22
ATOM 22 CA PRO 3 98. .152 16, .178 18. .217 1, .00 38, .90 1SG 23
ATOM 23 CD PRO 3 98. .872 14, .625 16. .544 1. .00 38, .90 1SG 24
ATOM 24 CB PRO 3 99. .440 16 , .726 17. .600 1. .00 38, .90 1SG 25
ATOM 25 CG PRO 3 99, .586 15, .960 16. .274 1, .00 38, .90 1SG 26
ATOM 26 C PRO 3 97, .024 17, .150 18, .183 1, .00 38 .90 1SG 27
ATOM 27 0 PRO 3 96. .311 17. .215 17. .184 1, .00 38, .90 1SG 28
ATOM 28 N GLY 4 96. .824 17, .879 19. .291 1. .00 38, .73 1SG 29
ATOM 29 CA GLY 4 95, .824 18 .900 19. .391 1, .00 38, .73 1SG 30
ATOM 30 C GLY 4 96 .228 20 .100 18. .594 1 .00 38 .73 1SG 31
ATOM 31 O GLY 4 95, .373 20, .804 18. .059 1. .00 38, .73 1SG 32
ATOM 32 N ILE 5 97 .541 20 .415 18, .565 1, .00 39 .81 1SG 33
ATOM 33 CA ILE 5 97 .979 21 .575 17, .842 1 .00 39 .81 1SG 34
ATOM 34 CB ILE 5 98, .379 22, .730 18. .709 1, .00 39, .81 1SG 35
ATOM 35 CG2 ILE 5 99, .719 22 .375 19, .376 1, .00 39 .81 1SG 36
ATOM 36 CGI ILE 5 98 .431 24 .021 17, .875 1 .00 39 .81 1SG 37
ATOM 37 CDl ILE 5 98, .457 25, .295 18. .718 1. .00 39 .81 1SG 38
ATOM 38 C ILE 5 99 .183 21 .204 17, .044 1. .00 39 .81 1SG 39
ATOM 39 0 ILE 5 99 .993 20 .381 17, .469 1 .00 39 .81 1SG 40
ATOM 40 N LYS 6 99, .317 21, .799 15. .844 1. .00 42, .45 1SG 41
ATOM 41 CA LYS 6 100 .454 21 .537 15, .014 1, .00 42 .45 1SG 42
ATOM 42 CB LYS 6 100 .085 20 .769 13, .726 1 .00 42 .45 1SG 43
ATOM 43 CG LYS 6 101 .246 20 .470 12, .768 1 .00 42 .45 1SG 44
ATOM 44 CD LYS 6 101 .799 21 .704 12, .047 1, .00 42 .45 1SG 45
ATOM 45 CE LYS 6 100 .805 22 .322 11, .059 1, .00 42 .45 1SG 46
ATOM 46 NZ LYS 6 99 .722 23 .021 11, .787 1 .00 42 .45 1SG 47
ATOM 47 C LYS 6 101 .034 22 .859 14 , .636 1. .00 42, .45 1SG 48
ATOM 48 O LYS 6 100 .306 23 .811 14, .358 1 .00 42 .45 1SG 49
ATOM 49 N ALA 7 102 .378 22 .952 14, .630 1 .00 42 .48 1SG 50
ATOM 50 CA ALA 7 103, .008 24 .179 14 , .250 1, .00 42, .48 1SG 51
ATOM 51 CB ALA 7 103 .961 24 .738 15, .320 1, .00 42, .48 1SG 52
ATOM 52 C ALA 7 103 .833 23 .883 13. .042 1 .00 42 .48 1SG 53
ATOM 53 0 ALA 7 104, .627 22, .944 13, .038 1, .00 42, .48 1SG 54
ATOM 54 N ARG 8 103 .653 24 .681 11, .974 1, .00 43, .95 1SG 55
ATOM 55 CA ARG 8 104 .433 24 .475 10, .792 1 .00 43 .95 1SG 56
ATOM 56 CB ARG 8 103, .614 24 .242 9. .514 1, .00 43, .95 1SG 57
ATOM 57 CG ARG 8 103 .137 22 .805 9. .323 1, .00 43, .95 1SG 58
ATOM 58 CD ARG 8 102 .395 22 .610 8, .000 1, .00 43 .95 1SG 59
ATOM 59 NE ARG 8 102 .277 21 .147 7. .756 1 .00 43 .95 1SG 60
ATOM 60 CZ ARG 8 102, .079 20, .690 6 , .486 1, .00 43, .95 1SG 61
ATOM 61 NHl ARG 8 101 .949 21 .576 5, .455 1, .00 43, .95 1SG 62 ATOM 62 NH2 ARG 8 102..021 19.,349 6,.242 1..00 43..95 1SG 63
ATOM 63 C ARG 8 105. .230 25. .706 10. .546 1. .00 43. ,95 1SG 64
ATOM 64 O ARG 8 104. .691 26. .803 10. .411 1. .00 43. .95 1SG 65
ATOM 65 N ILE 9 106, .555 25. .534 10. ,449 1. .00 43. ,06 1SG 66
ATOM 66 CA ILE 9 107. .426 26. ,640 10. ,218 1. .00 43. .06 1SG 67
ATOM 67 CB ILE 9 108. .590 26. .593 11. .166 1. .00 43. .06 1SG 68
ATOM 68 CG2 ILE 9 109. .324 25. .279 10. .907 1. .00 43. .06 1SG 69
ATOM 69 CGI ILE 9 109. .507 27. .800 11, .038 1. .00 43, .06 1SG 70
ATOM 70 CDl ILE 9 110. .376 27. .715 9. .791 1. .00 43, .06 1SG 71
ATOM 71 C ILE 9 107. .844 26. .532 8. .786 1. .00 43. .06 1SG 72
ATOM 72 O ILE 9 108, .352 25. .501 8. .347 1. .00 43, .06 1SG 73
ATOM 73 N THR 10 107, .584 27. .606 8, .013 1. .00 37. .37 1SG 74
ATOM 74 CA THR 10 107, .796 27. .617 6. .594 1. .00 37, .37 1SG 75
ATOM 75 CB THR 10 106. .811 28. .538 5. .913 1. ,00 37. .37 1SG 76
ATOM 76 OGl THR 10 105. .496 28. .172 6. .301 1. ,00 37. .37 1SG 77
ATOM 77 CG2 THR 10 106, .912 28. .421 4. .380 1. .00 37. .37 1SG 78
ATOM 78 C THR 10 109 .198 28. .067 6, .312 1. .00 37. .37 1SG 79
ATOM 79 O THR 10 109, .930 28. .492 7. .204 1. .00 37. .37 1SG 80
ATOM 80 N GLN 11 109 .605 27, .981 5. .031 1. .00 33. .68 1SG 81
ATOM 81 CA GLN 11 110, .925 28. .336 4. .618 1. .00 33. .68 1SG 82
ATOM 82 CB GLN 11 111 .175 28, .123 3 , .120 1. ,00 33. .68 1SG 83
ATOM 83 CG GLN 11 112, .607 28. .473 2. .722 1. .00 33. .68 1SG 84
ATOM 84 CD GLN 11 112 .780 28 .164 1 .246 1, .00 33, .68 1SG 85
ATOM 85 OEl GLN 11 111 .865 27. .678 0. .584 1. .00 33 .68 1SG 86
ATOM 86 NE2 GLN 11 113 .998 28 .453 0. .716 1. .00 33, .68 1SG 87
ATOM 87 C GLN 11 111 .128 29. .782 4. .921 1, .00 33 .68 1SG 88
ATOM 88 O GLN 11 112 .229 30. .196 5. .280 1. .00 33, .68 1SG 89
ATOM 89 N ARG 12 110 .065 30, .595 4. .783 1, .00 28 .86 1SG 90
ATOM 90 CA ARG 12 110, .197 31, .994 5. .060 1. .00 28, .86 1SG 91
ATOM 91 CB ARG 12 108, .869 32. .757 4. .919 1. .00 28, .86 1SG 92
ATOM 92 CG ARG 12 108 .989 34 .253 5 .220 1, .00 28 .86 1SG 93
ATOM 93 CD ARG 12 107 .672 35 .019 5. .084 1. .00 28 .86 1SG 94
ATOM 94 NE ARG 12 107 .952 36 .446 5 .410 1, .00 28, .86 1SG 95
ATOM 95 CZ ARG 12 107 .066 37, .420 5. .050 1. .00 28 .86 1SG 96
ATOM 96 NHl ARG 12 105 .934 37, .095 4. .359 1. .00 28, .86 1SG 97
ATOM 97 NH2 ARG 12 107 .311 38, .721 5. .384 1. .00 28 .86 1SG 98
ATOM 98 C ARG 12 110. .632 32, .122 6. .483 1. .00 28. .86 1SG 99
ATOM 99 O ARG 12 Ill .502 32 .928 6 .806 1. .00 28 .86 1SG 100
ATOM 100 N ALA 13 110 .024 31, .323 7 .378 1, .00 25. .47 1SG 101
ATOM 101 CA ALA 13 110 .363 31 .371 8, .770 1, .00 25, .47 1SG 102
ATOM 102 CB ALA 13 109 .444 30. .500 9 .642 1. .00 25, .47 1SG 103
ATOM 103 C ALA 13 111 .779 30 .914 8, .957 1. .00 25, .47 1SG 104
ATOM 104 0 ALA 13 112 .515 31. .466 9, .772 1. .00 25, .47 1SG 105
ATOM 105 N LEU 14 112 .190 29. .886 8, .193 1. .00 25. .15 1SG 106
ATOM 106 CA LEU 14 113. .495 29, .285 8. .272 1, .00 25. .15 1SG 107
ATOM 107 CB LEU 14 113 .627 28 .186 7 .205 1. .00 25. .15 1SG 108
ATOM 108 CG LEU 14 112 .561 27 .082 7, .327 1 .00 25 .15 1SG 109
ATOM 109 CD2 LEU 14 112 .708. 26 .317 8 .652 1. .00 25. .15 1SG 110
ATOM 110 CDl LEU 14 112 .580 26, .152 6, .104 1. .00 25 .15 1SG 111
ATOM 111 C LEU 14 114, .527 30 .314 7, .926 1, .00 25. .15 1SG 112
ATOM 112 0 LEU 14 115 .532 30, .468 8, .620 1. .00 25. .15 1SG 113
ATOM 113 N ASP 15 114, .280 31, .068 6, .840 1. .00 23. .72 1SG 114
ATOM 114 CA ASP 15 115 .239 32 .017 6 .355 1. .00 23 .72 1SG 115
ATOM 115 CB ASP 15 114 .759 32, .754 5 .093 1, .00 23, .72 1SG 116
ATOM 116 CG ASP 15 114 .725 31 .753 3, .946 1. .00 23. .72 1SG 117
ATOM 117 ODl ASP 15 115 .749 31, .049 3, .739 1. .00 23. .72 1SG 118
ATOM 118 OD2 ASP 15 113 .673 31, .687 3 , .257 1. .00 23. .72 1SG 119 ATOM 119 C ASP 15 115.,474 33.,044 7.,411 1.00 23.72 1SG 120
ATOM 120 O ASP 15 116. 606 33. ,475 7. 626 1. 00 23. .72 1SG 121
ATOM 121 N TYR 16 114. ,399 33. .460 8. .103 1. .00 23. .89 1SG 122
ATOM 122 CA TYR 16 114. ,509 34. .476 9. .106 1. 00 23. 89 1SG 123
ATOM 123 CB TYR 16 113. ,139 34. .854 9. ,699 1. 00 23. .89 1SG 124
ATOM 124 CG TYR 16 113. 325 35. .960 10. ,681 1. 00 23. .89 1SG 125
ATOM 125 CDl TYR 16 113. .503 37. .254 10. .247 1. .00 23. .89 1SG 126
ATOM 126 CD2 TYR 16 113. .306 35. .707 12. .033 1. .00 23. .89 1SG 127
ATOM 127 CE1 TYR 16 113. .668 38. .279 11. .149 1. ,00 23. 89 1SG 128
ATOM 128 CE2 TYR 16 113. .471 36. .728 12. .939 1. ,00 23. .89 1SG 129
ATOM 129 CZ TYR 16 113. .653 38, .016 12. .497 1. .00 23. .89 1SG 130
ATOM 130 OH TYR 16 113. .822 39. .066 13. .426 1. ,00 23. .89 1SG 131
ATOM 131 C TYR 16 115. .377 33, .957 10, .207 1. .00 23. .89 1SG 132
ATOM 132 O TYR 16 116. .251 34, .664 10. .706 1. .00 23. .89 1SG 133
ATOM 133 N GLY 17 115. .168 32, .687 10. .600 1. .00 23. .82 1SG 134
ATOM 134 CA GLY 17 115. .927 32, .126 11. .676 1. .00 23. .82 1SG 135
ATOM 135 C GLY 17 117. .376 32, .137 11. .292 1. .00 23. .82 1SG 136
ATOM 136 O GLY 17 118. .243 32, .430 12. .114 1. .00 23. .82 1SG 137
ATOM 137 N VAL 18 117. .670 31, .808 10, .021 1. .00 24. .12 1SG 138
ATOM 138 CA VAL 18 119. .019 31 .713 9 .533 1, .00 24. .12 1SG 139
ATOM 139 CB VAL 18 119. .066 31, .317 8. .089 1. .00 24. .12 1SG 140
ATOM 140 CGI VAL 18 120. .536 31, .240 7. .641 1. .00 24. .12 1SG 141
ATOM 141 CG2 VAL 18 118. .244 30, .037 7. .897 1. .00 24, .12 1SG 142
ATOM 142 C VAL 18 119. .685 33 .049 9 .603 1. .00 24, .12 1SG 143
ATOM 143 O VAL 18 120. .837 33, .159 10. .022 1. .00 24. .12 1SG 144
ATOM 144 N GLN 19 118, .971 34, .111 9, .187 1. .00 26, .03 1SG 145
ATOM 145 CA GLN 19 119, .553 35 .421 9, .123 1. .00 26 .03 1SG 146
ATOM 146 CB GLN 19 118. .563 36 .470 8, .590 1. .00 26, .03 1SG 147
ATOM 147 CG GLN 19 119 .171 37 .863 8 .430 1. .00 26 .03 1SG 148
ATOM 148 CD GLN 19 119. .964 37, .877 7, .131 1. .00 26, .03 1SG 149
ATOM 149 OEl GLN 19 119. .464 37 .454 6, .090 1. .00 26, .03 1SG 150
ATOM 150 NE2 GLN 19 121, .230 38 .371 7 .190 1 .00 26 .03 1SG 151
ATOM 151 C GLN 19 119 .941 35 .840 10, .502 1, .00 26 .03 ISG' 152
ATOM 152 O GLN 19 121 .030 36 .369 10 .717 1. .00 26 .03 1SG 153
ATOM 153 N ALA 20 119, .048 35 .604 11. .479 1. .00 26, .18 ISG 154
ATOM 154 CA ALA 20 119, .330 35 .990 12 .828 1. .00 26 .18 ISG 155
ATOM 155 CB ALA 20 118. .168 35 .689 13. .789 1. .00 26 .18 ISG 156
ATOM 156 C ALA 20 120 .514 35 .208 13 .292 1, .00 26 .18 ISG 157
ATOM 157 O ALA 20 121 .420 35 .748 13 .922 1, .00 26 .18 ISG 158
ATOM 158 N GLY 21 120. .546 33, .904 12. .963 1. .00 28 .58 ISG 159
ATOM 159 CA GLY 21 121 .599 33 .053 13 .434 1, .00 28 .58 ISG 160
ATOM 160 C GLY 21 122, .928 33 .496 12. .899 1, .00 28, .58 ISG 161
ATOM 161 O GLY 21 123 .899 33 .583 13, .646 1, .00 28 .58 ISG 162
ATOM 162 N MET 22 123 .010 33 .809 11, .594 1, .00 32 .12 ISG 163
ATOM 163 CA MET 22 124. .261 34 .175 10 .990 1, .00 32 .12 ISG 164
ATOM 164 CB MET 22 124 .093 34 .525 9 .504 1 .00 32 .12 ISG 165
ATOM 165 CG MET 22 125 .355 35 .083 8, .847 1, .00 32 .12 ISG 166
ATOM 166 SD MET 22 125 .057 35 .834 7, .220 1, .00 32 .12 ISG 167
ATOM 167 CE MET 22 124. .145 37, .257 7 .890 1, .00 32 .12 ISG 168
ATOM 168 C MET 22 124 .774 35 .415 11 .652 1 .00 32 .12 ISG 169
ATOM 169 O MET 22 125 .962 35 .535 11 .947 1 .00 32 .12 ISG 170
ATOM 170 N LYS 23 123. .887 36 .385 11, .914 1, .00 34, .42 ISG 171
ATOM 171 CA LYS 23 124 .366 37 .599 12 .499 1 .00 34 .42 ISG 172
ATOM 172 CB LYS 23 123 .258 38 .637 1 .733 1, .00 34 .42 ISG 173
ATOM 173 CG LYS 23 123 .797 39 .973 13 .244 1, .00 34 .42 ISG 174
ATOM 174 CD LYS 23 122 .790 41, .119 13, .144 1. .00 34, .42 ISG 175
ATOM 175 CE LYS 23 123 .346 42 .458 13, .631 1, .00 34 .42 ISG 176 ATOM 176 NZ LYS 23 122.350 43,.528 13.411 1..00 34.42 ISG 177
ATOM 177 C LYS 23 124 .965 37, .264 13 .825 1. .00 34 .42 ISG 178
ATOM 178 O LYS 23 126 .043 37, .742 14 .172 1. .00 34 .42 ISG 179
ATOM 179 N MET 24 124. .280 36, .403 14 .596 1. .00 38 .32 ISG 180
ATOM 180 CA MET 24 124, .774 36, .014 15. .883 1. .00 38 .32 ISG 181
ATOM 181 CB MET 24 123, .793 35, .131 16, .679 1. .00 38 .32 ISG 182
ATOM 182 CG MET 24 122, .747 35. .900 17, .499 1. .00 38 .32 ISG 183
ATOM 183 SD MET 24 121 .494 36 .831 16 .569 1, .00 38 .32 ISG 184
ATOM 184 CE MET 24 122 .486 38. .343 16 .407 1, .00 38 .32 ISG 185
ATOM 185 C MET 24 126 .052 35. .252 15 .721 1, .00 38 .32 ISG 186
ATOM 186 O MET 24 126 .952 35. .371 16 .550 1, .00 38 .32 ISG 187
ATOM 187 N ILE 25 126 .160 34. .422 14 .667 1, .00 39 .25 ISG 188
ATOM 188 CA ILE 25 127 .334 33. .611 14 .500 1. .00 39 .25 ISG 189
ATOM 189 CB ILE 25 127, .206 32. .512 13 .474 1. .00 39, .25 ISG 190
ATOM 190 CG2 ILE 25 126, .039 31. .618 13 .923 1. .00 39. .25 ISG 191
ATOM 191 CGI ILE 25 127 .050 33 .040 12 .043 1. .00 39 .25 ISG 192
ATOM 192 CDl ILE 25 127 .169 31 .957 10 .971 1. .00 39 .25 ISG 193
ATOM 193 C ILE 25 128 .533 34 .454 14 .188 1, .00 39 .25 ISG 194
ATOM 194 O ILE 25 129 .632 34. .163 14 .655 1. .00 39 .25 ISG 195
ATOM 195 N GLU 26 128 .364 35. .532 13 .401 1. .00 38 .98 ISG 196
ATOM 196 CA GLU 26 129 .497 36. .303 12 .966 1. .00 38 .98 ISG 197
ATOM 197 CB GLU 26 129, .112 37, .509 12 .091 1. .00 38 .98 ISG 198
ATOM 198 CG GLU 26 128 .290 38 .567 12 .828 1. .00 38 .98 ISG 199
ATOM 199 CD GLU 26 127 .999 39 .706 11 .864 1. .00 38 .98 ISG 200
ATOM 200 OEl GLU 26 128 .406 39 .596 10 .676 1, .00 38 .98 ISG 201
ATOM 201 OE2 GLU 26 127 .368 40, .703 12 .305 1. .00 38 .98 ISG 202
ATOM 202 C GLU 26 130, .262 36. .830 14 .143 1. .00 38 .98 ISG 203
ATOM 203 O GLU 26 131, .492 36, .815 14 .140 1. .00 38 .98 ISG 204
ATOM 204 N GLN 27 129, .564 37, .293 15, .194 1. .00 39 .68 ISG 205
ATOM 205 CA GLN 27 130, .257 37, .881 16, .304 1. .00 39. .68 ISG 206
ATOM 206 CB GLN 27 129 .307 38 .389 17 .402 1, .00 39 .68 ISG 207
ATOM 207 CG GLN 27 130, .031 39, .071 18 .565 1, .00 39 .68 ISG 208
ATOM 208 CD GLN 27 130, .620 40, .377 18 .047 1. .00 39 .68 ISG 209
ATOM 209 OEl GLN 27 130, .434 40, .738 16 .886 1. .00 39 .68 ISG 210
ATOM 210 NE2 GLN 27 131, .352 41. .107 18 .930 1. .00 39. .68 ISG 211
ATOM 211 C GLN 27 131, .163 36. .860 16, .918 1. .00 39, .68 ISG 212
ATOM 212 O GLN 27 132 , .301 37. .168 17, .269 1. .00 39, .68 ISG 213
ATOM 213 N MET 28 130, .686 35. .610 17 .056 1. .00 39 .39 ISG 214
ATOM 214 CA MET 28 131, .477 34, .585 17 .674 1. .00 39 .39 ISG 215
ATOM 215 CB MET 28 130, .716 33, .270 17 .906 1. .00 39, .39 ISG 216
ATOM 216 CG MET 28 131, .517 32. .278 18, .752 1. .00 39, .39 ISG 217
ATOM 217 SD MET 28 130. .534 30, .941 19, .491 1. ,00 39. .39 ISG 218
ATOM 218 CE MET 28 129. .889 31, .968 20, .846 1. ,00 39. .39 ISG 219
ATOM 219 C MET 28 132. .677 34. .300 16, .824 1. ,00 39. .39 ISG 220
ATOM 220 O MET 28 133. .761 34. .036 17, .341 1. ,00 39. .39 ISG 221
ATOM 221 N LEU 29 132. .514 34, .339 15, .488 1. ,00 41, .55 ISG 222
ATOM 222 CA LEU 29 133. .608 34, .060 14, .598 1. ,00 41. .55 ISG 223
ATOM 223 CB LEU 29 133. .217 34, .061 13, .108 1. .00 41. .55 ISG 224
ATOM 224 CG LEU 29 132. .549 32. .765 12, .609 1. .00 41. .55 ISG 225
ATOM 225 CD2 LEU 29 131. .318 32. .384 13, .439 1. 00 41. .55 ISG 226
ATOM 226 CDl LEU 29 133. ,571 31. .621 12 , .529 1. 00 41. .55 ISG 227
ATOM 227 C LEU 29 134. ,700 35. .076 14. .766 1. 00 41. .55 ISG 228
ATOM 228 O LEU 29 135. .880 34. .732 14. .728 1. ,00 41. .55 ISG 229
ATOM 229 N LYS 30 134. .339 36. .356 14. .965 1. ,00 43. .19 ISG 230
ATOM 230 CA LYS 30 135. .315 37. .409 15, .064 1. 00 43. .19 ISG 231
ATOM 231 CB LYS 30 134. .693 38. .806 15. .237 1. 00 43. ,19 ISG 232
ATOM 232 CG LYS 30 133. ,961 39. .312 13. .994 1. 00 43. ,19 ISG 233 ATOM 233 CD LYS 30 133..134 40,.576 14,.240 1,.00 43..19 ISG 234
ATOM 234 CE LYS 30 133. .986 41 .836 14, .407 1 .00 43, .19 ISG 235
ATOM 235 NZ LYS 30 133, .117 43, .031 14, .490 1, .00 43, .19 ISG 236
ATOM 236 C LYS 30 136, .200 37, .172 16, .249 1, .00 43, .19 ISG 237
ATOM 237 O LYS 30 137 .366 37 .559 16 .249 1 .00 43, .19 ISG 238
ATOM 238 N GLU 31 135 .646 36, .544 17, .299 1, .00 45, .18 ISG 239
ATOM 239 CA GLU 31 136 .300 36, .306 18, .556 1, .00 45, .18 ISG 240
ATOM 240 CB GLU 31 135 .347 35 .761 19 .633 1 .00 45 .18 ISG 241
ATOM 241 CG GLU 31 134 .282 36, .770 20, .067 1, .00 45, .18 ISG 242
ATOM 242 CD GLU 31 133, .420 36. .109 21, .131 1, .00 45, .18 ISG 243
ATOM 243 OEl GLU 31 133 .702 34. .928 21 .469 1 .00 45 .18 ISG 244
ATOM 244 OE2 GLU 31 132 .472 36. .777 21, .623 1, .00 45, .18 ISG 245
ATOM 245 C GLU 31 137, .445 35, .338 18, .451 1, .00 45, .18 ISG 246
ATOM 246 O GLU 31 138 .317 35 .340 19, .315 1, .00 45, .18 ISG 247
ATOM 247 N LYS 32 137, .472 34, .457 17, .435 1, .00 48, .89 ISG 248
ATOM 248 CA LYS 32 138, .459 33, .409 17, .396 1, .00 48, .89 ISG 249
ATOM 249 CB LYS 32 138 .342 32 .496 16 .160 1 .00 48, .89 ISG 250
ATOM 250 CG LYS 32 138 .668 33, .154 14, .818 1, .00 48, .89 ISG 251
ATOM 251 CD LYS 32 140 .162 33 .403 14 .603 1 .00 48 .89 ISG 252
ATOM 252 CE LYS 32 140 .521 33 .696 13, .146 1 .00 48 .89 ISG 253
ATOM 253 NZ LYS 32 141, .975 33, .944 13, .019 1, .00 48, .89 ISG 254
ATOM 254 C LYS 32 139 .855 33 .942 17 .490 1 .00 48 .89 ISG 255
ATOM 255 O LYS 32 140 .200 34 .983 16 .933 1 .00 48 .89 ISG 256
ATOM 256 N LYS 33 140, .707 33, .215 18, .245 1, .00 50, .95 ISG 257
ATOM 257 CA LYS 33 142 .062 33 .643 18 .417 1 .00 50 .95 ISG 258
ATOM 258 CB LYS 33 142 .506 33 .717 19, .889 1, .00 50, .95 ISG 259
ATOM 259 CG LYS 33 141, .861 34, .863 20, .672 1, .00 50, .95 ISG 260
ATOM 260 CD LYS 33 142 .234 36 .250 20 .141 1, .00 50, .95 ISG 261
ATOM 261 CE LYS 33 141 .594 37, .404 20, .916 1, .00 50, .95 ISG 262
ATOM 262 NZ LYS 33 142. .243 37, .549 22 , .238 1. .00 50, .95 ISG 263
ATOM 263 C LYS 33 142 .958 32 .660 17, .741 1, .00 50 .95 ISG 264
ATOM 264 O LYS 33 142. .854 31, .454 17, .958 1, .00 50, .95 ISG 265
ATOM 265 N LEU 34 143, .866 33, .160 16, .880 1, .00 54 , .67 ISG 266
ATOM 266 CA LEU 34 144 .788 32 .256 16 .268 1, .00 54, .67 ISG 267
ATOM 267 CB LEU 34 144, .815 32, .293 14 , .721 1, .00 54, .67 ISG 268
ATOM 268 CG LEU 34 145 .427 33 .534 14 .052 1 .00 54 .67 ISG 269
ATOM 269 CD2 LEU 34 144 .951 33, .673 12, .596 1, .00 54, .67 ISG 270
ATOM 270 CDl LEU 34 146, .956 33, .547 14, .183 1, .00 54, .67 ISG 271
ATOM 271 C LEU 34 146 .128 32 .541 16 .869 1, .00 54, .67 ISG 272
ATOM 272 O LEU 34 146, .454 33, .672 17, .229 1, .00 54. .67 ISG 273
ATOM 273 N PRO 35 146, .888 31. .495 17. .014 1. .00 55. .70 ISG 274
ATOM 274 CA PRO 35 148, .163 31. .548 17. .677 1. .00 55, .70 ISG 275
ATOM 275 CD PRO 35 146, .313 30, .163 17, .045 1. .00 55. .70 ISG 276
ATOM 276 CB PRO 35 148, .529 30. .097 18. .006 1. .00 55. .70 ISG 277
ATOM 277 CG PRO 35 147, .531 29. .243 17. .203 1. .00 55. .70 ISG 278
ATOM 278 C PRO 35 149, .210 32, .263 16. .895 1. .00 55. .70 ISG 279
ATOM 279 O PRO 35 148. .996 32. .580 15. .729 1. ,00 55. .70 ISG 280
ATOM 280 N ASP 36 150, .340 32, .582 17. .543 1. .00 52. .84 ISG 281
ATOM 281 CA ASP 36 151. .400 33, .237 16. .844 1. .00 52. .84 ISG 282
ATOM 282 CB ASP 36 152. .123 34, .304 17. .683 1. .00 52. ,84 ISG 283
ATOM 283 CG ASP 36 152. .710 33. .628 18. .911 1. .00 52. ,84 ISG 284
ATOM 284 ODl ASP 36 151. .969 32. .852 19. .572 1. .00 52. ,84 ISG 285
ATOM 285 OD2 ASP 36 153, .911 33. .872 19. .202 1. .00 52. .84 ISG 286
ATOM 286 C ASP 36 152. .382 32. .195 16. .437 1. ,00 52. ,84 ISG 287
ATOM 287 O ASP 36 152. .661 31. .261 17. ,187 1. ,00 52. ,84 ISG 288
ATOM 288 N LEU 37 152. .904 32. .302 15. ,201 1. ,00 49. .43 ISG 289
ATOM 289 CA LEU 37 153. .883 31. .335 14. ,827 1. .00 49. .43 ISG 290 ATOM 290 CB LEU 37 153.784 30.,748 13.,405 1.00 49.43 ISG 291
ATOM 291 CG LEU 37 152. .608 29. .759 13. .269 1. .00 49. 43 ISG 292
ATOM 292 CD2 LEU 37 152, ,418 28. .943 14. .557 1. ,00 49. ,43 ISG 293
ATOM 293 CDl LEU 37 152. .750 28. .871 12. .021 1. .00 49. ,43 ISG 294
ATOM 294 C LEU 37 155. .205 31. ,958 14. ,988 1. .00 49. .43 ISG 295
ATOM 295 O LEU 37 155. .365 33. .149 14. .736 1. .00 49. .43 ISG 296
ATOM 296 N SER 38 156. .162 31. .151 15. .480 1. .00 43. .68 ISG 297
ATOM 297 CA SER 38 157. .521 31. .549 15. .645 1. .00 43. .68 ISG 298
ATOM 298 CB SER 38 157. .918 31. .773 17. .112 1, .00 43, .68 ISG 299
ATOM 299 OG SER 38 157. .159 32. .841 17. .659 1. .00 43. ,68 ISG 300
ATOM 300 C SER 38 158. .316 30. .400 15. .129 1. .00 43. .68 ISG 301
ATOM 301 O SER 38 158. .015 29. .246 15, .435 1. .00 43, .68 ISG 302
ATOM 302 N GLY 39 159. .350 30. .678 14. .316 1. .00 39. .66 ISG 303
ATOM 303 CA GLY 39 160, .117 29. .583 13. .805 1. .00 39. .66 ISG 304
ATOM 304 C GLY 39 161, .416 30, .119 13. .302 1. .00 39. .66 ISG 305
ATOM 305 O GLY 39 161, .562 31, .320 13. .073 1. .00 39, .66 ISG 306
ATOM 306 N SER 40 162. .398 29, .210 13. .142 1. .00 39, .18 ISG 307
ATOM 307 CA SER 40 163. .699 29, .542 12. .640 1. .00 39, .18 ISG 308
ATOM 308 CB SER 40 164, .807 28, .645 13, .223 1, .00 39, .18 ISG 309
ATOM 309 OG SER 40 166, .074 29, .016 12, .701 1. .00 39, .18 ISG 310
ATOM 310 C SER 40 163, .669 29, .296 11 .166 1, .00 39 .18 ISG 311
ATOM 311 O SER 40 162, .707 28. .734 10, .646 1, .00 39, .18 ISG 312
ATOM 312 N GLU 41 164 .714 29. .743 10. .440 1, .00 38, .13 ISG 313
ATOM 313 CA GLU 41 164, .751 29. .480 9. .033 1. .00 38. .13 ISG 314
ATOM 314 CB GLU 41 163, .874 30. .427 8, .194 1. .00 38. .13 ISG 315
ATOM 315 CG GLU 41 163, .852 30. .073 6. .706 1. .00 38. .13 ISG 316
ATOM 316 CD GLU 41 162, .955 31. .076 5. .995 1. .00 38. .13 ISG 317
ATOM 317 OEl GLU 41 162, .440 31. .999 6, .680 1. .00 38. .13 ISG 318
ATOM 318 OE2 GLU 41 162 .771 30. .930 4. .757 1, .00 38. .13 ISG 319
ATOM 319 C GLU 41 166, .155 29. .643 8. .570 1. .00 38. .13 ISG 320
ATOM 320 O GLU 41 166, .937 30, .363 9, .187 1. .00 38, .13 ISG 321
ATOM 321 N SER 42 166, .516 28, .930 7, .485 1, .00 36, .24 ISG 322
ATOM 322 CA SER 42 167 .817 29, .085 6, .915 1. .00 36, .24 ISG 323
ATOM 323 CB SER 42 168, .785 27. .944 7, .268 1. .00 36 .24 ISG 324
ATOM 324 OG SER 42 168, .317 26. .720 6, .719 1, .00 36, .24 ISG 325
ATOM 325 C SER 42 167, .635 29. .068 5, .431 1. .00 36, .24 ISG 326
ATOM 326 0 SER 42 167 .074 28. .128 4, .870 1. .00 36 .24 ISG 327
ATOM 327 N LEU 43 168, .102 30. .133 4, .757 1 .00 35 .12 ISG 328
ATOM 328 CA LEU 43 168, .021 30. .207 3, .330 1, .00 35, .12 ISG 329
ATOM 329 CB LEU 43 167. .302 31, .488 2, .854 1. .00 35, .12 ISG 330
ATOM 330 CG LEU 43 166 .983 31, .577 1 .345 1. .00 35 .12 ISG 331
ATOM 331 CD2 LEU 43 168, .221 31, .364 0 .466 1. .00 35 .12 ISG 332
ATOM 332 CDl LEU 43 166, .273 32, .901 1, .019 1. .00 35, .12 ISG 333
ATOM 333 C LEU 43 169, .455 30, .254 2, .907 1. .00 35, .12 ISG 334
ATOM 334 0 LEU 43 170 .256 30, .956 3, .522 1. .00 35 .12 ISG 335
ATOM 335 N GLU 44 169. .829 29. .508 1, .849 1. .00 33. .33 ISG 336
ATOM 336 CA GLU 44 171. .220 29. .433 1. .501 1. ,00 33. .33 ISG 337
ATOM 337 CB GLU 44 171. .468 28. .590 0. .239 1. .00 33. .33 ISG 338
ATOM 338 CG GLU 44 171. .151 27. .104 0. .421 1. .00 33. .33 ISG 339
ATOM 339 CD GLU 44 171. .439 26 , .396 -0. .895 1. .00 33. .33 ISG 340
ATOM 340 OEl GLU 44 171. .860 27. ,089 -1. .859 1. .00 33. .33 ISG 341
ATOM 341 OE2 GLU 44 171, .238 25. .153 -0. .955 1. .00 33. .33 ISG 342
ATOM 342 C GLU 44 171, .739 30. .808 1. .231 1. .00 33. .33 ISG 343
ATOM 343 O GLU 44 172, .774 31. .202 1. .768 1. .00 33. .33 ISG 344
ATOM 344 N PHE 45 171. .036 31. .579 0. .384 1. .00 34. .13 ISG 345
ATOM 345 CA PHE 45 171. .472 32. ,911 0. .085 1. .00 34. .13 ISG 346
ATOM 346 CB PHE 45 170. .705 33. .533 -1. .095 1. ,00 34. .13 ISG 347 ATOM 347 CG PHE 45 171..053 32.,768 -2..325 1.,00 34.,13 ISG 348
ATOM 348 CDl PHE 45 170. ,399 31. ,596 -2. .628 1. .00 34. ,13 ISG 349
ATOM 349 CD2 PHE 45 172. ,033 33. ,224 -3. .177 1. .00 34. ,13 ISG 350
ATOM 350 CE1 PHE 45 170. .719 30. ,889 -3. ,763 1. ,00 34. ,13 ISG 351
ATOM 351 CE2 PHE 45 172. .356 32. .520 -4. ,313 1. ,00 34. .13 ISG 352
ATOM 352 CZ PHE 45 171. .699 31. .350 -4. ,609 1. ,00 34. ,13 ISG 353
ATOM 353 C PHE 45 171. .270 33. .818 1. ,263 1. .00 34. ,13 ISG 354
ATOM 354 O PHE 45 172. .167 34. .572 1. .638 1. .00 34. .13 ISG 355
ATOM 355 N LEU 46 170. .067 33. .760 1. .872 1. .00 38. .33 ISG 356
ATOM 356 CA LEU 46 169. .671 34. .691 2. .892 1. .00 38. .33 ISG 357
ATOM 357 CB LEU 46 168. .185 34. .555 3. .267 1. .00 38, .33 ISG 358
ATOM 358 CG LEU 46 167. .732 35. .548 4. .354 1. .00 38 , .33 ISG 359
ATOM 359 CD2 LEU 46 166. .314 35. .226 4. .851 1. .00 38. .33 ISG 360
ATOM 360 CDl LEU 46 167. .877 37. .002 3 , .878 1. .00 38, .33 ISG 361
ATOM 361 C LEU 46 170. .464 34. .575 4. .157 1 , .00 38, .33 ISG 362
ATOM 362 O LEU 46 170. .934 35. .596 4 , .653 1, .00 38, .33 ISG 363
ATOM 363 N LYS 47 170. .609 33. .341 4 , .696 1, .00 43, .33 ISG 364
ATOM 364 CA LYS 47 171. .296 33. .010 5. .926 1. .00 43, .33 ISG 365
ATOM 365 CB LYS 47 172, .082 34. .132 6. .636 1. .00 43, .33 ISG 366
ATOM 366 CG LYS 47 173, .498 34. .338 6, .084 1. .00 43 .33 ISG 367
ATOM 367 CD LYS 47 173, .559 34, .816 4. .631 1 .00 43 .33 ISG 368
ATOM 368 CE LYS 47 174, .984 35, .011 4. .109 1 .00 43 .33 ISG 369
ATOM 369 NZ LYS 47 175, .628 36, .145 4. .808 1 .00 43 .33 ISG 370
ATOM 370 C LYS 47 170. .301 32. .441 6. .887 1. .00 43 , .33 ISG 371
ATOM 371 O LYS 47 169. .188 32. .081 6. .505 1. .00 43, .33 ISG 372
ATOM 372 N VAL 48 170, .694 32. .322 8. .173 1. .00 46, .93 ISG 373
ATOM 373 CA VAL 48 169, .813 31. .743 9. .144 1, .00 46, .93 ISG 374
ATOM 374 CB VAL 48 170, .513 30. .862 10. .135 1. .00 46, .93 ISG 375
ATOM 375 CGI VAL 48 171, .132 29. .673 9, .382 1. .00 46, .93 ISG 376
ATOM 376 CG2 VAL 48 171, .536 31. .712 10, .909 1, .00 46, .93 ISG 377
ATOM 377 C VAL 48 169, .167 32. .848 9, .910 1. .00 46 .93 ISG 378
ATOM 378 O VAL 48 169, .814 33. .821 10, .294 1. .00 46 .93 ISG 379
ATOM 379 N ASP 49 167, .843 32, .725 10, .126 1, .00 49, .43 ISG 380
ATOM 380 CA ASP 49 167, .121 33. .728 10, .848 1. .00 49 .43 ISG 381
ATOM 381 CB ASP 49 166, .195 34. .585 9, .965 1. .00 49 .43 ISG 382
ATOM 382 CG ASP 49 165, .145 33. .682 9, .335 1, .00 49 .43 ISG 383
ATOM 383 ODl ASP 49 165, .369 32. .443 9, .307 1 .00 49 .43 ISG 384
ATOM 384 OD2 ASP 49 164, .106 34. .220 8, .867 1 .00 49 .43 ISG 385
ATOM 385 C ASP 49 166, .276 33. .062 11, .886 1 .00 49 .43 ISG 386
ATOM 386 O ASP 49 165, .875 31, .908 11, .737 1, .00 49 .43 ISG 387
ATOM 387 N TYR 50 166 .018 33, .776 12 .999 1 .00 56 .71 ISG 388
ATOM 388 CA TYR 50 165 .235 33 , .210 14 .051 1 .00 56 .71 ISG 389
ATOM 389 CB TYR 50 166 .054 32, .207 14 .908 1, .00 56 .71 ISG 390
ATOM 390 CG TYR 50 165 .176 31, .438 15, .849 1 .00 56 .71 ISG 391
ATOM 391 CDl TYR 50 164, .229 30, .559 15, .381 1 .00 56 .71 ISG 392
ATOM 392 CD2 TYR 50 165, .322 31. .585 17. .211 1. .00 56, .71 ISG 393
ATOM 393 CE1 TYR 50 163, .430 29. .854 16. .251 1, .00 56, .71 ISG 394
ATOM 394 CE2 TYR 50 164, .528 30. .885 18. .088 1, .00 56, .71 ISG 395
ATOM 395 CZ TYR 50 163, .577 30. .018 17. .607 1, .00 56. .71 ISG 396
ATOM 396 OH TYR 50 162, .759 29. .296 18. .501 1, .00 56, .71 ISG 397
ATOM 397 C TYR 50 164, .714 34. .341 14. .887 1, .00 56. .71 ISG 398
ATOM 398 O TYR 50 164, .213 35. .342 14 , .364 1, .00 56, .71 ISG 399
ATOM 399 N VAL 51 164, .800 34. .181 16. .227 1. .00 64, .70 ISG 400
ATOM 400 CA VAL 51 164, .185 35. .114 17. .106 1, .00 64, .70 ISG 401
ATOM 401 CB VAL 51 164. .635 36. .538 16. .900 1. .00 64, .70 ISG 402
ATOM 402 CGI VAL 51 163. .912 37. .492 17. .870 1, .00 64, .70 ISG 403
ATOM 403 CG2 VAL 51 166. .149 36. .546 17. .149 1, .00 64, .70 ISG 404 ATOM 404 C VAL 51 162..769 34,.870 16..755 1..00 64..70 ISG 405
ATOM 405 O VAL 51 162. .445 33, .768 16. .314 1. .00 64. .70 ISG 406
ATOM 406 N ASN 52 161, .854 35 .814 16. .970 1. .00 76, .93 ISG 407
ATOM 407 CA ASN 52 160. .584 35, .443 16. .461 1. .00 76. .93 ISG 408
ATOM 408 CB ASN 52 159. .442 36. .328 16. .994 1. .00 76, .93 ISG 409
ATOM 409 CG ASN 52 158. .117 35. .688 16. .612 1. .00 76. .93 ISG 410
ATOM 410 ODl ASN 52 157. .049 36. .167 16. .988 1. .00 76, .93 ISG 411
ATOM 411 ND2 ASN 52 158 .186 34 .566 15. .849 1, .00 76, .93 ISG 412
ATOM 412 C ASN 52 160. ,693 35. .660 14, .986 1, .00 76, .93 ISG 413
ATOM 413 O ASN 52 160. .369 36. .742 14. .498 1. .00 76. .93 ISG 414
ATOM 414 N TYR 53 161. .165 34. .651 14. .214 1. .00 88. .75 ISG 415
ATOM 415 CA TYR 53 161, .129 34. .954 12. .824 1. .00 88. .75 ISG 416
ATOM 416 CB TYR 53 162. .194 34 .218 11 .970 1. .00 88 .75 ISG 417
ATOM 417 CG TYR 53 161. .737 34 .216 10, .544 1, .00 88, .75 ISG 418
ATOM 418 CDl TYR 53 161. .726 35. .365 9. .789 1. .00 88. .75 ISG 419
ATOM 419 CD2 TYR 53 161. .289 33. .046 9, .965 1. .00 88. .75 ISG 420
ATOM 420 CE1 TYR 53 161, .279 35 .335 8 .488 1. .00 88 .75 ISG 421
ATOM 421 CE2 TYR 53 160, .840 33. .006 8, .672 1. .00 88. .75 ISG 422
ATOM 422 CZ TYR 53 160, .831 34 .158 7, .931 1, .00 88 .75 ISG 423
ATOM 423 OH TYR 53 160 .364 34 .119 6 .602 1 .00 88 .75 ISG 424
ATOM 424 C TYR 53 159, .784 34 .539 12, .400 1, .00 88 .75 ISG 425
ATOM 425 O TYR 53 159. .602 33. .380 12. .054 1. .00 88 .75 ISG 426
ATOM 426 N ASN 54 158. .801 35. .458 12. .557 1, .00 87 .19 ISG 427
ATOM 427 CA ASN 54 157, .498 35 .327 11. .980 1, .00 87 .19 ISG 428
ATOM 428 CB ASN 54 156 .988 3 .953 11 .474 1 .00 87 .19 ISG 429
ATOM 429 CG ASN 54 156. .990 32. .955 12. .577 1, .00 87 .19 ISG 430
ATOM 430 ODl ASN 54 157, .599 33. .300 13. .584 1. .00 87. .19 ISG 431
ATOM 431 ND2 ASN 54 156, .388 31 .749 12. .393 1, .00 87 .19 ISG 432
ATOM 432 C ASN 54 156 .412 36 .159 12. .573 1, .00 87 .19 ISG 433
ATOM 433 O ASN 54 156, .633 37. .300 12, .980 1 .00 87 .19 ISG 434
ATOM 434 N PHE 55 155 .185 35 .595 12. .596 1, .00 79 .90 ISG 435
ATOM 435 CA PHE 55 154, .032 36, .423 12. .786 1, .00 79, .90 ISG 436
ATOM 436 CB PHE 55 152, .985 36, .181 11. .686 1, .00 79 .90 ISG 437
ATOM 437 CG PHE 55 153. .650 36 .467 10. .380 1, .00 79 .90 ISG 438
ATOM 438 CDl PHE 55 154. .543 35, .567 9. .846 1, .00 79 .90 ISG 439
ATOM 439 CD2 PHE 55 153 .381 37 .617 9, .677 1, .00 79 .90 ISG 440
ATOM 440 CE1 PHE 55 155 .164 35 .811 8. .645 1 .00 79 .90 ISG 441
ATOM 441 CE2 PHE 55 153 .998 37, .866 8. .473 1, .00 79, .90 ISG 442
ATOM 442 CZ PHE 55 154, .893 36, .964 7. .953 1. .00 79, .90 ISG 443
ATOM 443 C PHE 55 153, .346 36, .200 14. .093 1. .00 79, .90 ISG 444
ATOM 444 O PHE 55 153 .249 35 .079 14. .592 1, .00 79 .90 ISG 445
ATOM 445 N SER 56 152 .820 37 .309 14. .665 1 .00 65 .68 ISG 446
ATOM 446 CA SER 56 152. .126 37. .244 15. .917 1. .00 65. .68 ISG 447
ATOM 447 CB SER 56 153. .066 37. .322 17. .131 1. .00 65. .68 ISG 448
ATOM 448 OG SER 56 154. .012 36. .263 17. .085 1. .00 65, .68 ISG 449
ATOM 449 C SER 56 151 .200 38 .422 16. .011 1. .00 65, .68 ISG 450
ATOM 450 O SER 56 151, .093 39. .226 15. .086 1. .00 65 .68 ISG 451
ATOM 451 N ASN > 57 150, .495 38, .530 17. .160 1. .00 52, .70 ISG 452
ATOM 452 CA ASN 57 149, .597 39, .615 17. .450 1. .00 52. .70 ISG 453
ATOM 453 CB ASN 57 150, .311 40, .971 17. .588 1. .00 52 , .70 ISG 454
ATOM 454 CG ASN 57 151. .173 40. .928 18. .843 1. .00 52. .70 ISG 455
ATOM 455 ODl ASN 57 152. .369 41. .210 18. ,799 1. ,00 52. .70 ISG 456
ATOM 456 ND2 ASN 57 150. .548 40, .567 19. .996 1. .00 52, .70 ISG 457
ATOM 457 C ASN 57 148. .579 39. .734 16. .365 1. .00 52, .70 ISG 458
ATOM 458 O ASN 57 148. .268 40, .831 15. .907 1. .00 52. .70 ISG 459
ATOM 459 N ILE 58 148. .000 38. ,591 15. .964 1. ,00 46. ,01 ISG 460
ATOM 460 CA ILE 58 147. .042 38. .529 14. ,902 1. ,00 46. .01 ISG 461 ATOM 461 CB ILE 58 146..933 37..128 14..346 1..00 46..01 ISG 462
ATOM 462 CG2 ILE 58 148. .357 36. .655 13, .997 1. .00 46. .01 ISG 463
ATOM 463 CGI ILE 58 146, .258 36. .158 15, .341 1, .00 46, .01 ISG 464
ATOM 464 CDl ILE 58 144, .725 36. .115 15, .284 1. .00 46. .01 ISG 465
ATOM 465 C ILE 58 145, .706 38, .872 15, .484 1, .00 46, .01 ISG 466
ATOM 466 O ILE 58 145 .365 38 .438 16 .584 1 .00 46 .01 ISG 467
ATOM 467 N LYS 59 144 .920 39 .699 14 .767 1 .00 40 .91 ISG 468
ATOM 468 CA LYS 59 143, .601 40 .020 15 .234 1. .00 40 .91 ISG 469
ATOM 469 CB LYS 59 143, .468 41, .458 15, .764 1. .00 40, .91 ISG 470
ATOM 470 CG LYS 59 144. .287 41, .724 17, .029 1, .00 40, .91 ISG 471
ATOM 471 CD LYS 59 144, .421 43, .211 17, .362 1, .00 40, .91 ISG 472
ATOM 472 CE LYS 59 145, .218 43, .997 16, .317 1. .00 40, .91 ISG 473
ATOM 473 NZ LYS 59 145, .283 45, .428 16, .692 1. .00 40, .91 ISG 474
ATOM 474 C LYS 59 142, .674 39, .891 14, .064 1. .00 40, .91 ISG 475
ATOM 475 O LYS 59 143, .101 39, .978 12, .915 1. .00 40, .91 ISG 476
ATOM 476 N ILE 60 141, .370 39, .673 14 , .338 1. .00 41, .66 ISG 477
ATOM 477 CA ILE 60 140, .378 39. .547 13 , .304 1. .00 41. .66 ISG 478
ATOM 478 CB ILE 60 139 .252 38 .612 13 .667 1. .00 41, .66 ISG 479
ATOM 479 CG2 ILE 60 138 .140 38 .782 12 .618 1, .00 41, .66 ISG 480
ATOM 480 CGI ILE 60 139 .731 37 .158 13, .790 1. .00 41 .66 ISG 481
ATOM 481 CDl ILE 60 140 .055 36 .517 12, .443 1, .00 41, .66 ISG 482
ATOM 482 C ILE 60 139 .751 40 .898 13, .167 1, .00 41, .66 ISG 483
ATOM 483 O ILE 60 139, .070 41 .368 14, .079 1. .00 41, .66 ISG 484
ATOM 484 N SER 61 140, .039 41. .583 12, .041 1. .00 41, .08 ISG 485
ATOM 485 CA SER 61 139, .493 42. .881 11. .762 1, .00 41, .08 ISG 486
ATOM 486 CB SER 61 140, .218 43. .584 10, .604 1. .00 41, .08 ISG 487
ATOM 487 OG SER 61 141, .581 43. .793 10, .937 1. .00 41, .08 ISG 488
ATOM 488 C SER 61 138, .056 42. .755 11, .368 1. .00 41. .08 ISG 489
ATOM 489 O SER 61 137 .193 43 .446 11, .908 1. .00 41. .08 ISG 490
ATOM 490 N ALA 62 137 .763 41 .868 10, .393 1. .00 42 .90 ISG 491
ATOM 491 CA ALA 62 136 .404 41. .713 9. .964 1, .00 42, .90 ISG 492
ATOM 492 CB ALA 62 136, .028 42 .636 8, .796 1. .00 42, .90 ISG 493
ATOM 493 C ALA 62 136, .218 40. .310 9, .483 1. .00 42, .90 ISG 494
ATOM 494 O ALA 62 137, .129 39. .708 8 , .916 1. .00 42. .90 ISG 495
ATOM 495 N PHE 63 135, .013 39. .751 9, .716 1. .00 48. .74 ISG 496
ATOM 496 CA PHE 63 134, .708 38. .416 9, .294 1. .00 48. .74 ISG 497
ATOM 497 CB PHE 63 134, .667 37. .477 10, .513 1. .00 48. .74 ISG 498
ATOM 498 CG PHE 63 134, .763 36, .051 10. .105 1. .00 48. .74 ISG 499
ATOM 499 CDl PHE 63 135. .953 35, .528 9. .668 1. .00 48. .74 ISG 500
ATOM 500 CD2 PHE 63 133. .678 35 .221 10. .183 1. .00 48. .74 ISG 501
ATOM 501 CE1 PHE 63 136. .068 34 .209 9. .301 1. .00 48. .74 ISG 502
ATOM 502 CE2 PHE 63 133. .784 33 .900 9. .816 1. .00 48. .74 ISG 503
ATOM 503 CZ PHE 63 134. .974 33 .384 9. .381 1. .00 48. .74 ISG 504
ATOM 504 C PHE 63 133, .336 38, .522 8. .706 1. .00 48. .74 ISG 505
ATOM 505 O PHE 63 132 , .339 38, .556 9. .424 1. .00 48. .74 ISG 506
ATOM 506 N SER 64 133, .225 38, .549 7. .368 1. .00 50. .23 ISG 507
ATOM 507 CA SER 64 131, .917 38, .795 6. .849 1. ,00 50. ,23 ISG 508
ATOM 508 CB SER 64 131. .906 39, .855 5. .735 1. ,00 50. ,23 ISG 509
ATOM 509 OG SER 64 132. .313 41. .109 6. .266 1. ,00 50. ,23 ISG 510
ATOM 510 C SER 64 131. .338 37. .535 6. ,305 1. ,00 50. ,23 ISG 511
ATOM 511 O SER 64 132. .016 36. .740 5. ,653 1. ,00 50. .23 ISG 512
ATOM 512 N PHE 65 130. .050 37. .316 6. .639 1. .00 51. ,38 ISG 513
ATOM 513 CA PHE 65 129. .271 36, .234 6. .105 1. ,00 51. .38 ISG 514
ATOM 514 CB PHE 65 128. .472 35, .432 7. .159 1. ,00 51. .38 ISG 515
ATOM 515 CG PHE 65 129. .360 34. .615 8. .032 1. ,00 51. .38 ISG 516
ATOM 516 CDl PHE 65 129. .797 33. .382 7. .609 1. ,00 51. 38 ISG 517
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© o ε εε εε εε ε ε ε ε ε ε ε ε ε PεPεPPεP PPPεεPεPεPεP PεPεεPεPεP PεεP dεεPεP P OεPεP PεPεεP PεPεεPεP PεεP PεPεP Pεdε ε PεPOεεOεPεPεPdε p o p p p p p p y?> y< y?ι y?ι y< y> y^ y^ yι i-ι f i y^ yA {i t< fri f-ι ?' H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H f-< {r< y^ i-ι yi y< ri yrr ft ft ft ft ft ft ft ft ft ft ft ft ft < ft ft ft ft ft ft ft ft ft < ft ft ft ft ft ft ft rt < ft < ft ft ft ft ft < < ft
ATOM 689 C ILE 89 144..301 40..482 9..450 1..00 34..93 ISG 690
ATOM 690 O ILE 89 144. .784 40. .762 8. .354 1. .00 34. .93 ISG 691
ATOM 691 N SER 90 144. .763 41. .016 10, .600 1. .00 38, .73 ISG 692
ATOM 692 CA SER 90 145, .878 41. .918 10 .585 1. .00 38, .73 ISG 693
ATOM 693 CB SER 90 145. .445 43. .376 10. .797 1. ,00 38. .73 ISG 694
ATOM 694 OG SER 90 146. .554 44. .243 10. .639 1. .00 38. .73 ISG 695
ATOM 695 C SER 90 146. .788 41. .521 11. .710 1. .00 38, .73 ISG 696
ATOM 696 O SER 90 146 .325 41 .062 12 .754 1. .00 38 .73 ISG 697
ATOM 697 N THR 91 148. .122 41. .659 11. .522 1. .00 41 .14 ISG 698
ATOM 698 CA THR 91 149. .030 41. .216 12, .547 1. .00 41. .14 ISG 699
ATOM 699 CB THR 91 149. .409 39. .774 12, .385 1, .00 41, .14 ISG 700
ATOM 700 OGl THR 91 150 .236 39 .620 11 .240 1. .00 41 .14 ISG 701
ATOM 701 CG2 THR 91 148. .127 38. .951 12 .186 1 .00 41 .14 ISG 702
ATOM 702 C THR 91 150, .327 41, .961 12, .414 1. .00 41. .14 ISG 703
ATOM 703 O THR 91 150, .457 42, .896 11 .626 1. .00 41. .14 ISG 704
ATOM 704 N ASP 92 151 .323 41 .550 13 .231 1. .00 48. .20 ISG 705
ATOM 705 CA ASP 92 152 .655 42 .091 13 .201 1. .00 48 .20 ISG 706
ATOM 706 CB ASP 92 153 .091 42 .734 14 .529 1, .00 48. .20 ISG 707
ATOM 707 CG ASP 92 152, .249 43, .982 14, .744 1. .00 48. .20 ISG 708
ATOM 708 ODl ASP 92 151 .544 44, .390 13 .783 1. .00 48. .20 ISG 709
ATOM 709 OD2 ASP 92 152 .294 44 .541 15 .873 1 .00 48 .20 ISG 710
ATOM 710 C ASP 92 153 .573 40, .931 12 .965 1. .00 48. .20 ISG 711
ATOM 711 O ASP 92 153. .171 39, .780 13, .125 1. .00 48. .20 ISG 712
ATOM 712 N TRP 93 154 .827 41, .202 12 .541 1. .00 58. .37 ISG 713
ATOM 713 CA TRP 93 155 .768 40 .140 12 .323 1. .00 58 .37 ISG 714
ATOM 714 CB TRP 93 155. .803 39 .653 10 .866 1. .00 58. .37 ISG 715
ATOM 715 CG TRP 93 156 .099 40 .761 9 .890 1. .00 58. .37 ISG 716
ATOM 716 CD2 TRP 93 157. .421 41, .221 9, .578 1. .00 58, .37 ISG 717
ATOM 717 CDl TRP 93 155 .237 41 .534 9 .171 1. .00 58, .37 ISG 718
ATOM 718 NE1 TRP 93 155, .940 42, .456 8, .434 1. .00 58 .37 ISG 719
ATOM 719 CE2 TRP 93 157 .286 42, .274 8 .674 1. .00 58, .37 ISG 720
ATOM 720 CE3 TRP 93 158 .645 40 .804 10 .014 1 .00 58 .37 ISG 721
ATOM 721 CZ2 TRP 93 158, .382 42, .929 8 .190 1. .00 58, .37 ISG 722
ATOM 722 CZ3 TRP 93 159, .748 41, .463 9, .522 1. .00 58 .37 ISG 723
ATOM 723 CH2 TRP 93 159, .617 42, .505 8 .629 1, .00 58, .37 ISG 724
ATOM 724 C TRP 93 157 .130 40 .645 12 .679 1, .00 58, .37 ISG 725
ATOM 725 O TRP 93 157, .358 41, .854 12, .749 1, .00 58, .37 ISG 726
ATOM 726 N GLY 94 158. .072 39. .706 12, .919 1, .00 68, .71 ISG 727
ATOM 727 CA GLY 94 159. .407 40. .057 13, .296 1, .00 68. .71 ISG 728
ATOM 728 C GLY 94 160, .339 39. .135 12 .580 1, .00 68. .71 ISG 729
ATOM 729 O GLY 94 159 .974 38 .051 1 .127 1, .00 68. .71 ISG 730
ATOM 730 N PHE 95 161. .603 39. .567 12, .536 1, .00 79, .38 ISG 731
ATOM 731 CA PHE 95 162. .705 39. .028 11, .799 1. .00 79. .38 ISG 732
ATOM 732 CB PHE 95 163. .479 40. .184 11, .072 1, .00 79. .38 ISG 733
ATOM 733 CG PHE 95 164, .182 40. .909 12, .221 1, .00 79. .38 ISG 734
ATOM 734 CDl PHE 95 163, .430 41. .606 13, .146 1. .00 79. .38 ISG 735
ATOM 735 CD2 PHE 95 165. .552 40. .900 12, .460 1. .00 79. .38 ISG 736
ATOM 736 CE1 PHE 95 163. .966 42. .243 14, .238 1. .00 79. .38 ISG 737
ATOM 737 CE2 PHE 95 166, .102 41. .514 13 .565 1. .00 79. .38 ISG 738
ATOM 738 CZ PHE 95 165 .316 42. .188 14 .463 1. .00 79. .38 ISG 739
ATOM 739 C PHE 95 163. .765 38. ,692 12. .789 1. .00 79, .38 ISG 740
ATOM 740 O PHE 95 163. .694 38. .986 13, .985 1. .00 79. .38 ISG 741
ATOM 741 N GLU 96 164. .847 38. .122 12, .229 1. .00 78. .35 ISG 742
ATOM 742 CA GLU 96 166. .113 38. .076 1 .891 1. .00 78. .35 ISG 743
ATOM 743 CB GLU 96 166. .204 37. .216 14, .155 1. .00 78. ,35 ISG 744
ATOM 744 CG GLU 96 167. ,636 37. .192 14. .702 1. .00 78. ,35 ISG 745
ATOM 745 CD GLU 96 167. .913 38. .529 15. .375 1. .00 78. ,35 ISG 746 ATOM 746 OEl GLU 96 167.,705 39..581 14..713 1..00 78..35 ISG 747
ATOM 747 OE2 GLU 96 168. .331 38, .517 16. .564 1. .00 78. .35 ISG 748
ATOM 748 C GLU 96 167. .103 37. .489 11. .955 1. .00 78. ,35 ISG 749
ATOM 749 O GLU 96 167. ,222 36. .271 11. .873 1. .00 78. .35 ISG 750
ATOM 750 N SER 97 167. ,838 38. .335 11. .215 1. .00 73. .56 ISG 751
ATOM 751 CA SER 97 168. ,967 37. .826 10. .497 1. .00 73. .56 ISG 752
ATOM 752 CB SER 97 169. ,206 38. .456 9, .117 1. .00 73. .56 ISG 753
ATOM 753 OG SER 97 169. .649 39, .793 9. .270 1, .00 73. .56 ISG 754
ATOM 754 C SER 97 170. .000 38. .334 11. .417 1, .00 73. .56 ISG 755
ATOM 755 O SER 97 169. .654 39. .279 12, .120 1. .00 73. .56 ISG 756
ATOM 756 N PRO 98 171. .189 37, .788 11, .473 1, .00 66. .70 ISG 757
ATOM 757 CA PRO 98 172. .143 38. .159 12, .493 1. .00 66. .70 ISG 758
ATOM 758 CD PRO 98 171. .849 37. .341 10, .257 1. .00 66. .70 ISG 759
ATOM 759 CB PRO 98 173. ,486 37. .609 12. .022 1. .00 66. .70 ISG 760
ATOM 760 CG PRO 98 173. ,346 37. .604 10, .490 1. .00 66. .70 ISG 761
ATOM 761 C PRO 98 172. .211 39. .630 12, .763 1, .00 66. .70 ISG 762
ATOM 762 O PRO 98 171. .742 40. .042 13 .823 1. .00 66. .70 ISG 763
ATOM 763 N LEU 99 172. .721 40. .427 11, .813 1. .00 59. .26 ISG 764
ATOM 764 CA LEU 99 172. .785 41, .851 11, .955 1. .00 59, .26 ISG 765
ATOM 765 CB LEU 99 173. .782 42, .487 10 .973 1. .00 59. .26 ISG 766
ATOM 766 CG LEU 99 173. .878 44, .018 11, .095 1, .00 59. .26 ISG 767
ATOM 767 CD2 LEU 99 174. .693 44. .619 9, .939 1. .00 59. .26 ISG 768
ATOM 768 CDl LEU 99 174. .409 44. .434 12, .476 1. .00 59. .26 ISG 769
ATOM 769 C LEU 99 171. .457 42. .516 11, .724 1. .00 59. .26 ISG 770
ATOM 770 O LEU 99 171, .106 43. .467 12 .420 1. .00 59. .26 ISG 771
ATOM 771 N PHE 100 170. .687 42 , .038 10, .725 1. .00 56 , .73 ISG 772
ATOM 772 CA PHE 100 169. .552 42. .793 10 .275 1. .00 56. .73 ISG 773
ATOM 773 CB PHE 100 169. .126 42. .486 8 .827 1, .00 56. .73 ISG 774
ATOM 774 CG PHE 100 170 .230 42 .928 7 .928 1, .00 56 .73 ISG 775
ATOM 775 CDl PHE 100 170. .321 44. .240 7, .523 1. .00 56. .73 ISG 776
ATOM 776 CD2 PHE 100 171. .174 42. .029 7, .487 1. .00 56. .73 ISG 777
ATOM 777 CE1 PHE 100 171, .339 44. .649 6, .694 1. .00 56. .73 ISG 778
ATOM 778 CE2 PHE 100 172, .194 42. .432 6 .658 1. .00 56. .73 ISG 779
ATOM 779 CZ PHE 100 172. .278 43 , .744 6 .260 1, .00 56, .73 ISG 780
ATOM 780 C PHE 100 168. .354 42, .640 11, .139 1. .00 56. .73 ISG 781
ATOM 781 O PHE 100 168. .087 41, .572 11 .689 1. .00 56. .73 ISG 782
ATOM 782 N GLN 101 167 .609 43 .763 11 .247 1. .00 51. .83 ISG 783
ATOM 783 CA GLN 101 166, .409 43 .899 12 .011 1. .00 51, .83 ISG 784
ATOM 784 CB GLN 101 166, .489 44. .997 13 , .085 1. ,00 51. .83 ISG 785
ATOM 785 CG GLN 101 165, .208 45. .142 13 , .910 1. .00 51. .83 ISG 786
ATOM 786 CD GLN 101 165, .425 46. .253 14, .929 1. .00 51. .83 ISG 787
ATOM 787 OEl GLN 101 165, .320 46. .037 16 .134 1. .00 51. .83 ISG 788
ATOM 788 NE2 GLN 101 165, .734 47, .481 14 , .432 1. ,00 51. .83 ISG 789
ATOM 789 C GLN 101 165, .290 44, .249 11, .095 1. .00 51. .83 ISG 790
ATOM 790 O GLN 101 165, .395 45. .173 10 .291 1. .00 51. .83 ISG 791
ATOM 791 N ASP 102 164 .175 43 .501 11 .187 1. .00 45. .73 ISG 792
ATOM 792 CA ASP 102 163, .077 43, .826 10, .335 1. .00 45. .73 ISG 793
ATOM 793 CB ASP 102 163. .028 42. .986 9, .046 1. .00 45. .73 ISG 794
ATOM 794 CG ASP 102 164. .189 43, .403 8. .155 1. ,00 45. .73 ISG 795
ATOM 795 ODl ASP 102 164. .413 44, .634 8, .011 1. .00 45. .73 ISG 796
ATOM 796 OD2 ASP 102 164. .862 42. .495 7, .598 1. .00 45. .73 ISG 797
ATOM 797 C ASP 102 161, .801 43. .564 11, .068 1. ,00 45. .73 ISG 798
ATOM 798 0 ASP 102 161, .485 42, .428 11, .416 1. .00 45. .73 ISG 799
ATOM 799 N THR 103 161, .022 44, .628 11, .317 1. .00 38. .77 ISG 800
ATOM 800 CA THR 103 159, .765 44, .472 11 .988 1. .00 38. .77 ISG 801
ATOM 801 CB THR 103 159, .759 45, .048 13, .374 1. .00 38. .77 ISG 802
ATOM 802 OGl THR 103 160. .764 44. .429 14. .163 1. .00 38. .77 ISG 803 ^ ιo ^ oo ι_ O H c< ^f ln ^D ^ (D (Λ o ri ( n ^ ι ιo ^ <o crl O ri ( l l ιD ^ c() (^ι o ri C n * ιn ιo ^ π) cn o ri P^ rn '. ιn ^n ^ x ol o o o o o o o ri ri ri ri ri ri ri ri ri ri cN C CN CN CN CN CN CN CN CN n ro ro ro M ro ro ro ro ro ^ ^ Mi ^ i ^ ^ ^ ^ ^ in in in in in in in in in in vo
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ATOM 917 CGI ILE 119 121..299 23.,014 12.,197 1.00 28.39 ISG 918
ATOM 918 CDl ILE 119 120. .532 24. .307 11. .924 1. 00 28. .39 ISG 919
ATOM 919 C ILE 119 120. .246 19. .374 12. .332 1. 00 28. ,39 ISG 920
ATOM 920 O ILE 119 119. .464 19. .136 11. .413 1. 00 28. .39 ISG 921
ATOM 921 N ILE 120 120. .286 18. ,630 13. .456 1. ,00 29. .99 ISG 922
ATOM 922 CA ILE 120 119. .405 17. .513 13. .630 1. ,00 29. .99 ISG 923
ATOM 923 CB ILE 120 120. .094 .16, .257 14. .093 1. ,00 29. .99 ISG 924
ATOM 924 CG2 ILE 120 120, .737 16. .528 15. .463 1. ,00 29. .99 ISG 925
ATOM 925 CGI ILE 120 119, .109 15, .074 14. .080 1. .00 29. ,99 ISG 926
ATOM 926 CDl ILE 120 119, .775 13. .713 14. .275 1. .00 29. ,99 ISG 927
ATOM 927 C ILE 120 118, .408 17. .890 14, .673 1. .00 29. .99 ISG 928
ATOM 928 O ILE 120 118, .758 18. .410 15, .732 1. .00 29. .99 ISG 929
ATOM 929 N LEU 121 117, .116 17. .654 14, .375 1. .00 32. .64 ISG 930
ATOM 930 CA LEU 121 116, .080 18. .020 15, .296 1. .00 32. .64 ISG 931
ATOM 931 CB LEU 121 114 .876 18. .683 14 .610 1. .00 32. .64 ISG 932
ATOM 932 CG LEU 121 115, .226 19. .983 13, .864 1. .00 32. .64 ISG 933
ATOM 933 CD2 LEU 121 115, .971 20. .971 14, .775 1. .00 32. .64 ISG 934
ATOM 934 CDl LEU 121 113, .982 20. .597 13 .206 1, .00 32. .64 ISG 935
ATOM 935 C LEU 121 115, .570 16. .773 15 .938 1. .00 32. .64 ISG 936
ATOM 936 O LEU 121 115 .346 15, .763 15 .274 1. .00 32. .64 ISG 937
ATOM 937 N THR 122 115 .386 16, .809 17 .270 1, .00 35. .23 ISG 938
ATOM 938 CA THR 122 114 .842 15, .666 17 .936 1, .00 35 .23 ISG 939
ATOM 939 CB THR 122 115. .866 14. .670 18, .411 1. .00 35, .23 ISG 940
ATOM 940 OGl THR 122 116. .800 15. .270 19 .292 1. .00 35, .23 ISG 941
ATOM 941 CG2 THR 122 116. .595 14. .104 17, .181 1, .00 35, .23 ISG 942
ATOM 942 C THR 122 114 .001 16, .151 19 .072 1, .00 35, .23 ISG 943
ATOM 943 O THR 122 113 .801 17, .352 19 .246 1, .00 35, .23 ISG 944
ATOM 944 N ARG 123 113 .441 15, .209 19 .850 1, .00 38. .55 ISG 945
ATOM 945 CA ARG 123 112 .558 15, .568 20 .918 1, .00 38. .55 ISG 946
ATOM 946 CB ARG 123 111 .099 15, .196 20 .609 1 .00 38, .55 ISG 947
ATOM 947 CG ARG 123 110, .208 15. .085 21, .846 1, .00 38, .55 ISG 948
ATOM 948 CD ARG 123 108, .788 14. .628 21 .508 1. .00 38, .55 ISG 949
ATOM 949 NE ARG 123 108 .149 14 , .162 22 .770 1, .00 38, .55 ISG 950
ATOM 950 CZ ARG 123 108 .186 12. .835 23 .091 1, .00 38, .55 ISG 951
ATOM 951 NHl ARG 123 108 .803 11. .950 22 .254 1, .00 38, .55 ISG 952
ATOM 952 NH2 ARG 123 107 .599 12, .391 24 .240 1 .00 38, .55 ISG 953
ATOM 953 C ARG 123 112 .949 14, .802 2 .131 1, .00 38, .55 ISG 954
ATOM 954 O ARG 123 113. .546 13, .730 22 .044 1, .00 38 .55 ISG 955
ATOM 955 N ASN 124 112, .630 15, .355 23 .315 1. .00 39, .93 ISG 956
ATOM 956 CA ASN 124 112 .890 14, .610 24 .503 1, .00 39, .93 ISG 957
ATOM 957 CB ASN 124 113 .848 15, .277 25 .515 1, .00 39, .93 ISG 958
ATOM 958 CG ASN 124 113 .215 16, .530 26 .090 1, .00 39, .93 ISG 959
ATOM 959 ODl ASN 124 112 .209 17, .018 25 .584 1, .00 39, .93 ISG 960
ATOM 960 ND2 ASN 124 113 .825 17, .076 27 .177 1, .00 39, .93 ISG 961
ATOM 961 C ASN 124 111 .560 14, .392 25 .141 1, .00 39, .93 ISG 962
ATOM 962 O ASN 124 110, .614 15. .142 24, .916 1. .00 39, .93 ISG 963
ATOM 963 N ASP 125 111, .465 13. .344 25 .967 1. .00 40, .56 ISG 964
ATOM 964 CA ASP 125 110 .244 12, .939 26 .596 1. .00 40, .56 ISG 965
ATOM 965 CB ASP 125 110, .450 11, .735 27 .529 1. .00 40, .56 ISG 966
ATOM 966 CG ASP 125 110 .886 10, .546 26 .686 1, .00 40, .56 ISG 967
ATOM 967 ODl ASP 125 110 .504 10, .498 25 .487 1. .00 40, .56 ISG 968
ATOM 968 OD2 ASP 125 111 .610 9. .670 27 .231 1. .00 40, .56 ISG 969
ATOM 969 C ASP 125 109 .764 14, .069 27 .449 1. .00 40, .56 ISG 970
ATOM 970 O ASP 125 108, .569 14. .184 27, .712 1. .00 40. .56 ISG 971
ATOM 971 N PHE 126 110, .691 14. .932 27, .906 1. .00 42. .75 ISG 972
ATOM 972 CA PHE 126 110, .337 16. .033 28, .755 1. .00 42. .75 ISG 973
ATOM 973 CB PHE 126 111 .533 16. .914 29, .146 1. .00 42. .75 ISG 974 ATOM 974 CG PHE 126 111,.109 17..637 30..376 1..00 42 ,.75 ISG 975
ATOM 975 CDl PHE 126 110, .438 18. .835 30. .304 1. .00 42, .75 ISG 976
ATOM 976 CD2 PHE 126 111, .371 17. .085 31, .611 1. .00 42, .75 ISG 977
ATOM 977 CE1 PHE 126 110. .055 19. .478 31, .458 1. .00 42, .75 ISG 978
ATOM 978 CE2 PHE 126 110, .991 17. .724 32. .766 1. .00 42, .75 ISG 979
ATOM 979 CZ PHE 126 110, .329 18, .925 32. .688 1. .00 42, .75 ISG 980
ATOM 980 C PHE 126 109, .362 16, .849 27, .963 1, .00 42, .75 ISG 981
ATOM 981 O PHE 126 108, .475 17, .500 28. .516 1. .00 42. .75 ISG 982
ATOM 982 N GLY 127 109. .508 16, .833 26. .625 1, .00 43. .33 ISG 983
ATOM 983 CA GLY 127 108. .550 17, .514 25. .805 1. .00 43. .33 ISG 984
ATOM 984 C GLY 127 109. .182 18, .699 25. .155 1. .00 43. .33 ISG 985
ATOM 985 O GLY 127 108, .535 19, .394 24. .373 1. .00 43. .33 ISG 986
ATOM 986 N HIS 128 110. .464 18. .960 25. .465 1, .00 46. .84 ISG 987
ATOM 987 CA HIS 128 Ill, .148 20. .066 24. .862 1. .00 46. .84 ISG 988
ATOM 988 NDl HIS 128 111. .743 20. .623 28. .223 1. .00 46. .84 ISG 989
ATOM 989 CG HIS 128 111. .804 21, .288 27. .019 1. .00 46. .84 ISG 990
ATOM 990 CB HIS 128 112. .270 20, .661 25. .735 1, .00 46. .84 ISG 991
ATOM 991 NE2 HIS 128 111. .065 22. .705 28. .614 1. .00 46, .84 ISG 992
ATOM 992 CD2 HIS 128 111. .386 22. .558 27. .276 1. .00 46. .84 ISG 993
ATOM 993 CE1 HIS 128 111. .296 21. .516 29. .142 1. .00 46. .84 ISG 994
ATOM 994 C HIS 128 111. .800 19, .585 23. .600 1, .00 46, .84 ISG 995
ATOM 995 O HIS 128 112. .208 18. .431 23. .477 1. .00 46. .84 ISG 996
ATOM 996 N PRO 129 111. .867 20. .463 22. .638 1. .00 49. .46 ISG 997
ATOM 997 CA PRO 129 112 .515 20 .123 21. .400 1 .00 49 .46 ISG 998
ATOM 998 CD PRO 129 110 .790 21 .421 22 .444 1 .00 49 .46 ISG 999
ATOM 999 CB PRO 129 112. .016 21. .132 20, .370 1, .00 49 .46 1SG1000
ATOM 1000 CG PRO 129 110. .652 21 .579 20, .922 1, .00 49 .46 1SG1001
ATOM 1001 C PRO 129 113. .992 20 .189 21, .592 1. .00 49 .46 1SG1002
ATOM 1002 O PRO 129 114, .443 20 .881 22, .504 1. .00 49 .46 1SG1003
ATOM 1003 N THR 130 114, .777 19. .476 20, .767 1, .00 50 .12 1SG1004
ATOM 1004 CA THR 130 116, .191 19. .594 20, .941 1, .00 50. .12 1SG1005
ATOM 1005 CB THR 130 116, .759 18 .531 21, .839 1, .00 50 .12 1SG1006
ATOM 1006 OGl THR 130 lie. .162 18 .687 21, .983 1, .00 50 .12 1SG1007
ATOM 1007 CG2 THR 130 116, .397 17, .150 21, .290 1, .00 50 .12 1SG1008
ATOM 1008 C THR 130 116. .855 19, .604 19, .601 1. .00 50. .12 1SG1009
ATOM 1009 O THR 130 116. .369 18, .999 18, .645 1. .00 50. .12 1SG1010
ATOM 1010 N LEU 131 117, .977 20 .344 19, .496 1. .00 49, .63 1SG1011
ATOM 1011 CA LEU 131 118. .701 20. .467 18, .264 1. .00 49, .63 1SG1012
ATOM 1012 CB LEU 131 118. .541 21, .847 17. .604 1. .00 49. .63 1SG1013
ATOM 1013 CG LEU 131 117. .089 22, .183 17. .220 1. .00 49. .63 1SG1014
ATOM 1014 CD2 LEU 131 117. .020 23 .443 16. .343 1. .00 49. .63 1SG1015
ATOM 1015 CDl LEU 131 116. .188 22, .275 18. .463 1. .00 49. .63 1SG1016
ATOM 1016 C LEU 131 120. .158 20, .320 18. .577 1. .00 49. .63 1SG1017
ATOM 1017 O LEU 131 120. .623 20, .754 19. .629 1. ,00 49. .63 1SG1018
ATOM 1018 N LYS 132 120. .925 19, .684 17. .673 1. .00 45. .80 1SG1019
ATOM 1019 CA LYS 132 122 .337 19 .558 17 .897 1. .00 45. .80 1SG1020
ATOM 1020 CB LYS 132 122. .740 18, .232 18, .566 1. .00 45, .80 1SG1021
ATOM 1021 CG LYS 132 122. .198 18, .074 19, .989 1. .00 45, .80 1SG1022
ATOM 1022 CD LYS 132 122. .321 16 .651 20, .539 1. .00 45, .80 1SG1023
ATOM 1023 CE LYS 132 121, .781 16 .494 21, .962 1. .00 45, .80 1SG1024
ATOM 1024 NZ LYS 132 121. .921 15, .089 22, .404 1. .00 45, .80 1SG1025
ATOM 1025 C LYS 132 122. .980 19, .587 16. .550 1. .00 45. .80 1SG1026
ATOM 1026 O LYS 132 122. .324 19, .306 15, .548 1. .00 45. .80 1SG1027
ATOM 1027 N LEU 133 124. .279 19, .949 16, .461 1. .00 44. .95 1SG1028
ATOM 1028 CA LEU 133 124. .813 19 .900 15, .133 1. .00 44. .95 1SG1029
ATOM 1029 CB LEU 133 125. .578 21, .151 14. .639 1. ,00 44. .95 1SG1030
ATOM 1030 CG LEU 133 126. .988 21, .439 15. .179 1. ,00 44. .95 1SG1031 ATOM 1031 CD2 LEU 133 127..397 22..865 14.,784 1.,00 44.,95 1SG1032
ATOM 1032 CDl LEU 133 128. .026 20. .411 14. ,702 1. ,00 44. .95 1SG1033
ATOM 1033 C LEU 133 125. ,620 18. ,652 14. ,989 1. 00 44. .95 1SG1034
ATOM 1034 O LEU 133 126. .538 18. .379 15. 762 1. 00 44. .95 1SG1035
ATOM 1035 N GLN 134 125. ,204 17. .814 14. ,018 1. ,00 43. .02 1SG1036
ATOM 1036 CA GLN 134 125. .821 16. .549 13. ,745 1. ,00 43. ,02 1SG1037
ATOM 1037 CB GLN 134 124. .990 15. .687 12. ,779 1. ,00 43. .02 1SG1038
ATOM 1038 CG GLN 134 123. .629 15, .266 13. .334 1. ,00 43. .02 1SG1039
ATOM 1039 CD GLN 134 122. .936 14, .430 12. .268 1. .00 43, ,02 1SG1040
ATOM 1040 OEl GLN 134 121. .834 13, .924 12. .472 1. .00 43, .02 1SG1041
ATOM 1041 NE2 GLN 134 123. .602 14, .277 11. .092 1. .00 43. .02 1SG1042
ATOM 1042 C GLN 134 127. .163 16. .724 13. .107 1. ,00 43. ,02 1SG1043
ATOM 1043 O GLN 134 128. .129 16. .078 13. .509 1. ,00 43, .02 1SG1044
ATOM 1044 N ASP 135 127. .260 17. .600 12. .085 1. .00 42, .99 1SG1045
ATOM 1045 CA ASP 135 128. .504 17. .704 11. .376 1. ,00 42. .99 1SG1046
ATOM 1046 CB ASP 135 128. .527 16. .858 10. .089 1. .00 42. ,99 1SG1047
ATOM 1047 CG ASP 135 129, .957 16. .771 9. .571 1. .00 42, .99 1SG1048
ATOM 1048 ODl ASP 135 130, .896 17. .095 10, .345 1. .00 42 .99 1SG1049
ATOM 1049 OD2 ASP 135 130, .127 16. .374 8, .387 1, .00 42 .99 1SG1050
ATOM 1050 C ASP 135 128, .731 19. .126 10, .969 1, .00 42 .99 1SG1051
ATOM 1051 O ASP 135 127, .788 19, .893 10. .782 1. .00 42, .99 1SG1052
ATOM 1052 N CYS 136 130, .016 19, .513 10. .834 1. .00 43, .69 1SG1053
ATOM 1053 CA CYS 136 130, .358 20, .841 10. .421 1. .00 43 .69 1SG1054
ATOM 1054 CB CYS 136 130, .764 21. .733 11, .593 1. .00 43, .69 1SG1055
ATOM 1055 SG CYS 136 132, .327 21. .115 12, .258 1. .00 43 .69 1SG1056
ATOM 1056 C CYS 136 131 .573 20. .727 9, .555 1. .00 43 .69 1SG1057
ATOM 1057 O CYS 136 132 .404 19 .839 9. .742 1. .00 43 .69 1SG1058
ATOM 1058 N TYR 137 131 .693 21 .618 8, .553 1. .00 42 .08 1SG1059
ATOM 1059 CA TYR 137 132 .849 21 .608 7 .708 1 .00 42 .08 1SG1060
ATOM 1060 CB TYR 137 132, .627 20, .801 6, .416 1. .00 42 .08 1SG1061
ATOM 1061 CG TYR 137 133, .866 20, .838 5, .587 1. .00 42 .08 1SG1062
ATOM 1062 CDl TYR 137 134, .949 20, .059 5, .918 1, .00 42 .08 1SG1063
ATOM 1063 CD2 TYR 137 133 .937 21, .636 4. .467 1. .00 42 .08 1SG1064
ATOM 1064 CE1 TYR 137 136 .092 20 .083 5, .155 1, .00 42 .08 1SG1065
ATOM 1065 CE2 TYR 137 135 .077 21 .664 3 .699 1 .00 42 .08 1SG1066
ATOM 1066 CZ TYR 137 136 .158 20 .888 4 .044 1 .00 42 .08 1SG1067
ATOM 1067 OH TYR 137 137 .329 20 .916 3 .258 1 .00 42 .08 1SG1068
ATOM 1068 C TYR 137 133 .129 23 .025 7 .323 1 .00 42 .08 1SG1069
ATOM 1069 O TYR 137 132, .209 23, .801 7, .072 1, .00 42 .08 1SG1070
ATOM 1070 N ALA 138 134 .419 23 .396 7, .256 1, .00 40 .64 1SG1071
ATOM 1071 CA ALA 138 134 .802 24, .719 6, .855 1, .00 40 .64 1SG1072
ATOM 1072 CB ALA 138 135 .638 25 .458 7, .915 1, .00 40 .64 1SG1073
ATOM 1073 C ALA 138 135 .686 24 .520 5, .667 1 .00 40 .64 1SG1074
ATOM 1074 O ALA 138 136 .212 23 .427 5, .469 1 .00 40 .64 1SG1075
ATOM 1075 N GLN 139 135 .835 25 .549 4 .808 1 .00 38 .40 1SG1076
ATOM 1076 CA GLN 139 136 .708 25 .389 3 .680 1 .00 38 .40 1SG1077
ATOM 1077 CB GLN 139 136 .001 24 .838 2 .431 1 .00 38 .40 1SG1078
ATOM 1078 CG GLN 139 136 .938 24, .669 1, .234 1, .00 38 .40 1SG1079
ATOM 1079 CD GLN 139 136 .121 24 .124 0, .074 1, .00 38 .40 1SG1080
ATOM 1080 OEl GLN 139 134 .910 23 .939 0, .186 1 .00 38 .40 1SG1081
ATOM 1081 NE2 GLN 139 136 .799 23 .859 -1, .075 1 .00 38 .40 1SG1082
ATOM 1082 C GLN 139 137 .258 26 .731 3, .312 1 .00 38 .40 1SG1083
ATOM 1083 O GLN 139 136 .513 27 .698 3 .165 1 .00 38 .40 1SG1084
ATOM 1084 N LEU 140 138 .595 26 .810 3 .145 1 .00 37 .18 1SG1085
ATOM 1085 CA LEU 140 139 .253 28 .032 2 .779 1 .00 37 .18 1SG1086
ATOM 1086 CB LEU 140 140 .393 28 .409 3 .744 1 .00 37 .18 1SG1087
ATOM 1087 CG LEU 140 141 .319 29, .518 3, .205 1, .00 37 .18 1SG1088 ATOM 1088 CD2 LEU 140 140.506 30.603 2,.484 1,.00 37..18 1SG1089
ATOM 1089 CDl LEU 140 142 .420 28 .958 2, .289 1, .00 37 .18 1SG1090
ATOM 1090 C LEU 140 139 .827 27 .888 1 .404 1 .00 37 .18 1SG1091
ATOM 1091 O LEU 140 140, .568 26 .947 1, .122 1, .00 37. .18 1SG1092
ATOM 1092 N SER 141 139 .449 28 .817 0, .501 1, .00 34. .51 1SG1093
ATOM 1093 CA SER 141 139 .927 28 .834 -0 .854 1 .00 34 .51 1SG1094
ATOM 1094 CB SER 141 139 .102 29 .766 -1 .757 1 .00 34 .51 1SG1095
ATOM 1095 OG SER 141 137 .766 29 .294 -1, .855 1, .00 34 .51 1SG1096
ATOM 1096 C SER 141 141 .353 29 .291 -0 .940 1 .00 34 .51 1SG1097
ATOM 1097 O SER 141 142 .227 28 .534 -1 .362 1 .00 34 .51 1SG1098
ATOM 1098 N HIS 142 141 .633 30 .553 -0 .538 1 .00 34 .36 1SG1099
ATOM 1099 CA HIS 142 142 .965 31 .061 -0 .726 1 .00 34 .36 1SG1100
ATOM 1100 NDl HIS 142 145 .269 33 .211 -1 .949 1 .00 34 .36 1SG1101
ATOM 1101 CG HIS 142 144 .522 32 .155 -2, .422 1, .00 34 .36 1SG1102
ATOM 1102 CB HIS 142 143 .104 31 .872 -2 .028 1 .00 34 .36 1SG1103
ATOM 1103 NE2 HIS 142 146 .572 32 .094 -3 .363 1 .00 34 .36 1SG1104
ATOM 1104 CD2 HIS 142 145, .334 31, .483 -3, .284 1, .00 34. .36 1SG1105
ATOM 1105 CE1 HIS 142 146 .486 33 .127 -2 .544 1, .00 34 .36 1SG1106
ATOM 1106 C HIS 142 143 .320 31 .972 0 .410 1 .00 34 .36 1SG1107
ATOM 1107 O HIS 142 142 .451 32 .434 1 .148 1 .00 3 .36 1SG1108
ATOM 1108 N ALA 143 144, .634 32, .234 0. .587 1, .00 35 .24 1SG1109
ATOM 1109 CA ALA 143 145 .079 33 .117 1 .628 1 .00 35 .24 1SG1110
ATOM 1110 CB ALA 143 145 .874 32 .393 2 .732 1 .00 35 .24 1SG1111
ATOM llll C ALA 143 146 .013 34 .106 1 .007 1 .00 35 .24 1SG1112
ATOM 1112 O ALA 143 147, .058 33 .739 0, .469 1, .00 35 .24 1SG1113
ATOM 1113 N HIS 144 145 .675 35 .406 1, .091 1 .00 37 .28 1SG1114
ATOM 1114 CA HIS 144 146, .530 36 .386 0, .493 1, .00 37 .28 1SG1115
ATOM 1115 NDl HIS 144 143 .896 36 .270 -1, .569 1 .00 37 .28 1SG1116
ATOM 1116 CG HIS 144 145, .128 36 .885 -1, .560 1, .00 37 .28 1SG1117
ATOM 1117 CB HIS 144 145, .779 37, .445 -0. .331 1, .00 37. .28 1SG1118
ATOM 1118 NE2 HIS 144 144, .639 36 .234 -3, .664 1, .00 37 .28 1SG1119
ATOM 1119 CD2 HIS 144 145 .568 36 .855 -2 .848 1 .00 37 .28 1SG1120
ATOM 1120 CE1 HIS 144 143 , .653 35. .900 -2. .852 1, .00 37 .28 1SG1121
ATOM 1121 C HIS 144 147. .229 37. .106 1. .592 1, .00 37. .28 1SG1122
ATOM 1122 O HIS 144 146. .613 37 .845 2. .358 1, .00 37 .28 1SG1123
ATOM 1123 N VAL 145 148 .554 36 .909 1 .698 1 .00 42 .25 1SG1124
ATOM 1124 CA VAL 145 149. .246 37, .614 2. .728 1 .00 42 .25 1SG1125
ATOM 1125 CB VAL 145 150. .277 36, .766 3. .435 1. .00 42. .25 1SG1126
ATOM 1126 CGI VAL 145 151, .437 36 .418 2. .492 1, .00 42 .25 1SG1127
ATOM 1127 CG2 VAL 145 150, .694 37, .479 4. .724 1, .00 42. .25 1SG1128
ATOM 1128 C VAL 145 149, .859 38. .808 2. .069 1 .00 42 .25 1SG1129
ATOM 1129 O VAL 145 150, .688 38, .689 1. .168 1, .00 42, .25 1SG1130
ATOM 1130 N SER 146 149. .431 40. ,017 2. .483 1. .00 44. .39 1SG1131
ATOM 1131 CA SER 146 149. .936 41. .167 1. .799 1. .00 44 , .39 1SG1132
ATOM 1132 CB SER 146 148. .844 42. .196 1. .460 1, .00 44. .39 1SG1133
ATOM 1133 OG SER 146 149. .413 43. .307 0. .785 1. .00 44. .39 1SG1134
ATOM 1134 C SER 146 150. .942 41. .860 2. .653 1. .00 44. .39 1SG1135
ATOM 1135 O SER 146 150. .650 42. ,882 3. .272 1. .00 44 , .39 1SG1136
ATOM 1136 N PHE 147 152. .170 41, .314 2. .688 1. .00 45. .99 1SG1137
ATOM 1137 CA PHE 147 153. ,262 41. .936 3. .373 1. .00 45. .99 1SG1138
ATOM 1138 CB PHE 147 154. .495 41. .030 3. .506 1. .00 45. .99 1SG1139
ATOM 1139 CG PHE 147 155. .586 41. .900 4. .024 1. .00 45. .99 1SG1140
ATOM 1140 CDl PHE 147 155. ,628 42. .268 5. .348 1. .00 45. ,99 1SG1141
ATOM 1141 CD2 PHE 147 156. .573 42 , .348 3. .177 1. .00 45. .99 1SG1142
ATOM 1142 CE1 PHE 147 156. ,641 43. ,073 5. ,814 1. .00 45. ,99 1SG1143
ATOM 1143 CE2 PHE 147 157. 587 43. 152 3. 640 1. 00 45. 99 1SG1144
ATOM 1144 CZ PHE 147 157. .620 43. ,520 4. 961 1. .00 45. ,99 1SG1145 C ι vD t-- oo n o H
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ATOM 1316 ND2 ASN 169 144..812 27,.556 15,.799 1.,00 37..37 1SG1317
ATOM 1317 C ASN 169 142. .058 26, .723 12, .624 1. .00 37. .37 1SG1318
ATOM 1318 O ASN 169 141. .126 26 .624 13, .419 1. .00 37, .37 1SG1319
ATOM 1319 N LEU 170 142. .021 27, .564 11, .574 1. .00 38. .84 1SG1320
ATOM 1320 CA LEU 170 140. .895 28, .422 11, .341 1. .00 38, .84 1SG1321
ATOM 1321 CB LEU 170 141, .101 29 .370 10, .149 1. .00 38, .84 1SG1322
ATOM 1322 CG LEU 170 139, .897 30 .297 9 .896 1. .00 38, .84 1SG1323
ATOM 1323 CD2 LEU 170 140, .038 31, .045 8, .560 1. .00 38, .84 1SG1324
ATOM 1324 CDl LEU 170 139. .656 31, .238 11, .084 1. .00 38, .84 1SG1325
ATOM 1325 C LEU 170 139. .682 27 .600 11 .050 1. .00 38, .84 1SG1326
ATOM 1326 O LEU 170 138. .597 27 .876 11 .556 1. .00 38 .84 1SG1327
ATOM 1327 N ASN 171 139. .822 26, .559 10, .218 1. ,00 41, .60 1SG1328
ATOM 1328 CA ASN 171 138. .665 25, .783 9, .902 1. .00 41, .60 1SG1329
ATOM 1329 CB ASN 171 138, .876 24, .775 8 .751 1. .00 41, .60 1SG1330
ATOM 1330 CG ASN 171 140, .003 23 .822 9 .094 1, .00 41 .60 1SG1331
ATOM 1331 ODl ASN 171 139, .937 23, .089 10, .077 1. .00 41, .60 1SG1332
ATOM 1332 ND2 ASN 171 141, .068 23, .826 8 .249 1. .00 41. .60 1SG1333
ATOM 1333 C ASN 171 138, .198 25 .097 11 .140 1, .00 41 .60 1SG1334
ATOM 1334 O ASN 171 137, .000 24 .889 11 .327 1, .00 41 .60 1SG1335
ATOM 1335 N GLU 172 139, .148 24, .706 12, .009 1. .00 43. .91 1SG1336
ATOM 1336 CA GLU 172 138, .810 24, .066 13 .240 1. .00 43 .91 1SG1337
ATOM 1337 CB GLU 172 140, .045 23 .544 13 .994 1. .00 43 .91 1SG1338
ATOM 1338 CG GLU 172 139 .709 22 .851 15 .316 1. .00 43 .91 1SG1339
ATOM 1339 CD GLU 172 141, .014 22, .387 15, .948 1. .00 43. .91 1SG1340
ATOM 1340 OEl GLU 172 141, .932 21, .988 15 .183 1. .00 43, .91 1SG1341
ATOM 1341 OE2 GLU 172 141. .111 22 .427 17 .203 1. .00 43 .91 1SG1342
ATOM 1342 C GLU 172 138, .113 25 .043 14 .131 1. .00 43 .91 1SG1343
ATOM 1343 O GLU 172 137, .086 24, .722 14 .701 1. .00 43, .91 1SG1344
ATOM 1344 N MET 173 138, .601 26 .283 14 .281 1. .00 48 .37 1SG1345
ATOM 1345 CA MET 173 137, .962 27 .162 15 .220 1. .00 48 .37 1SG1346
ATOM 1346 CB MET 173 138, .710 28 .497 15 .380 1, .00 48 .37 1SG1347
ATOM 1347 CG MET 173 140. .091 28, .310 16, .012 1. .00 48, .37 1SG1348
ATOM 1348 SD MET 173 141. .052 29, .834 16 .244 1. .00 48 .37 1SG1349
ATOM 1349 CE MET 173 142. .533 28 .967 16 .837 1. .00 48 .37 1SG1350
ATOM 1350 C MET 173 136. .550 27 .443 14 .807 1, .00 48 .37 1SG1351
ATOM 1351 O MET 173 135. .649 27 .450 15 .643 1, .00 48 .37 1SG1352
ATOM 1352 N LEU 174 136, .300 27, .656 13 .504 1. .00 51 .29 1SG1353
ATOM 1353 CA LEU 174 134, .964 27 .972 13 .086 1. .00 51 .29 1SG1354
ATOM 1354 CB LEU 174 134, .830 28 .231 11 .573 1, .00 51 .29 1SG1355
ATOM 1355 CG LEU 174 135, .300 29 .631 11 .128 1, .00 51 .29 1SG1356
ATOM 1356 CD2 LEU 174 135, .034 29, .848 9 .630 1. .00 51, .29 1SG1357
ATOM 1357 CDl LEU 174 136, .760 29, .905 11 .512 1. .00 51, .29 1SG1358
ATOM 1358 C LEU 174 134, .027 26 .861 13 .459 1. .00 51, .29 1SG1359
ATOM 1359 0 LEU 174 132, .945 27 .125 13 .978 1. .00 51, .29 1SG1360
ATOM 1360 N CYS 175 134, .411 25, .591 13, .226 1. .00 53. .40 1SG1361
ATOM 1361 CA CYS 175 133 , .557 24, .474 13 .536 1. .00 53, .40 1SG1362
ATOM 1362 CB CYS 175 134, .210 23, .134 13 .158 1. .00 53, .40 1SG1363
ATOM 1363 SG CYS 175 133, .704 22 .432 11 .575 1. .00 53, .40 1SG1364
ATOM 1364 C CYS 175 133. .216 24 , .444 15, .008 1. ,00 53. .40 1SG1365
ATOM 1365 O CYS 175 132. .030 24, .343 15, .309 1. .00 53. .40 1SG1366
ATOM 1366 N PRO 176 134. .126 24, .478 15 .962 1. .00 52. .86 1SG1367
ATOM 1367 CA PRO 176 133. .631 24, .629 17 .295 1. .00 52, .86 1SG1368
ATOM 1368 CD PRO 176 135. .080 23, .375 16, .015 1. .00 52. .86 1SG1369
ATOM 1369 CB PRO 176 134. .790 24 , .316 18, .227 1. .00 52, .86 1SG1370
ATOM 1370 CG PRO 176 135. .451 23. .146 17, .491 1. ,00 52 , .86 1SG1371
ATOM 1371 C PRO 176 132. .839 25. .841 17, .633 1. .00 52, .86 1SG1372
ATOM 1372 O PRO 176 131. ,986 25. .728 18. .510 1. .00 52. .86 1SG1373 ATOM 1373 N ILE 177 133..069 27..003 17..001 1.00 47.75 1SG1374
ATOM 1374 CA ILE 177 132. .191 28. .074 17. ,363 1. 00 47. .75 1SG1375
ATOM 1375 CB ILE 177 132. .511 29. .383 16. ,691 1. 00 47. ,75 1SG1376
ATOM 1376 CG2 ILE 177 131. .207 30. .192 16. .595 1. .00 47. ,75 1SG1377
ATOM 1377 CGI ILE 177 133. .650 30. .127 17. .417 1. 00 47. ,75 1SG1378
ATOM 1378 CDl ILE 177 135. .006 29. .432 17. ,413 1. 00 47. ,75 1SG1379
ATOM 1379 C ILE 177 130. .796 27, .697 16. .976 1. ,00 47. .75 1SG1380
ATOM 1380 O ILE 177 129. .868 27, .820 17. .774 1. ,00 47. .75 1SG1381
ATOM 1381 N ILE 178 130. .615 27. .189 15. .745 1. ,00 42. .75 1SG1382
ATOM 1382 CA ILE 178 129, .300 26, .870 15. .266 1. ,00 42. .75 1SG1383
ATOM 1383 CB ILE 178 129, .290 26, .449 13. .813 1. .00 42. .75 1SG1384
ATOM 1384 CG2 ILE 178 129 .937 25, .061 13. .686 1, .00 42. .75 1SG1385
ATOM 1385 CGI ILE 178 127, .873 26, .539 13. .210 1. .00 42. .75 1SG1386
ATOM 1386 CDl ILE 178 126, .838 25, .600 13. .829 1. .00 42. .75 1SG1387
ATOM 1387 C ILE 178 128, .686 25, .791 16, .111 1. .00 42. .75 1SG1388
ATOM 1388 O ILE 178 127 .521 25 .893 16, .492 1. .00 42, .75 1SG1389
ATOM 1389 N ALA 179 129, .445 24, .732 16, .443 1. .00 35, .48 1SG1390
ATOM 1390 CA ALA 179 128, .887 23, .643 17, .194 1. .00 35, .48 1SG1391
ATOM 1391 CB ALA 179 129 .897 22 .508 17, .434 1, .00 35, .48 1SG1392
ATOM 1392 C ALA 179 128 .441 24 .137 18, .532 1, .00 35 .48 1SG1393
ATOM 1393 O ALA 179 127 .361 23 .779 19 .001 1, .00 35 .48 1SG1394
ATOM 1394 N SER 180 129 .266 24, .978 19, .181 1, .00 31, .22 1SG1395
ATOM 1395 CA SER 180 128 .965 25 .461 20, .499 1, .00 31 .22 1SG1396
ATOM 1396 CB SER 180 130, .106 26, .303 21. .097 1. .00 31, .22 1SG1397
ATOM 1397 OG SER 180 130 .285 27, .490 20, .338 1. .00 31, .22 1SG1398
ATOM 1398 C SER 180 127, .746 26, .327 20. .466 1. .00 31. .22 1SG1399
ATOM 1399 O SER 180 126 .895 26, .249 21. .350 1. .00 31. .22 1SG1400
ATOM 1400 N GLU 181 127 .628 27, .172 19, .427 1. .00 29. .82 1SG1401
ATOM 1401 CA GLU 181 126 .540 28 .099 19, .311 1. .00 29, .82 1SG1402
ATOM 1402 CB GLU 181 126, .646 28, .988 18, .060 1. .00 29, .82 1SG1403
ATOM 1403 CG GLU 181 127, .798 29, .994 18, .114 1. .00 29, .82 1SG1404
ATOM 1404 CD GLU 181 127 .405 31 .106 19, .075 1, .00 29, .82 1SG1405
ATOM 1405 OEl GLU 181 126 .725 30 .799 20 .091 1. .00 29 .82 1SG1406
ATOM 1406 OE2 GLU 181 127 .774 32, .280 18, .803 1 .00 29 .82 1SG1407
ATOM 1407 C GLU 181 125 .262 27, .335 19, .204 1, .00 29, .82 1SG1408
ATOM 1408 O GLU 181 124 .223 27 .773 19 .695 1. .00 29, .82 1SG1409
ATOM 1409 N VAL 182 125 .307 26 .160 18 .557 1, .00 29 .06 1SG1410
ATOM 1410 CA VAL 182 124 .117 25, .389 18, .354 1 .00 29 .06 1SG1411
ATOM 1411 CB VAL 182 124 .397 24. .064 17, .707 1, .00 29, .06 1SG1412
ATOM 1412 CGI VAL 182 123 .082 23 .273 17 .618 1, .00 29, .06 1SG1413
ATOM 1413 CG2 VAL 182 125 .070 24 .317 16 .348 1, .00 29 .06 1SG1414
ATOM 1414 C VAL 182 123 .518 25 .119 19 .689 1 .00 29 .06 1SG1415
ATOM 1415 O VAL 182 122 .303 25, .208 19, .862 1, .00 29, .06 1SG1416
ATOM 1416 N LYS 183 124 .365 24 .807 20 .683 1, .00 30, .15 1SG1417
ATOM 1417 CA LYS 183 123 .854 24 .528 21 .989 1, .00 30, .15 1SG1418
ATOM 1418 CB LYS 183 124 .964 24, .263 23, .020 1, .00 30, .15 1SG1419
ATOM 1419 CG LYS 183 125, .781 23. .005 22. .720 1. .00 30. .15 1SG1420
ATOM 1420 CD LYS 183 127, .068 22. .896 23. .541 1. .00 30. .15 1SG1421
ATOM 1421 CE LYS 183 127, .890 21, .647 23. .221 1. .00 30. .15 1SG1422
ATOM 1422 NZ LYS 183 128 .564 21, .810 21. .913 1, .00 30. .15 1SG1423
ATOM 1423 C LYS 183 123, .099 25. .748 22. .431 1. .00 30. .15 1SG1424
ATOM 1424 O LYS 183 122, .047 25. .636 23. .055 1. .00 30. .15 1SG1425
ATOM 1425 N ALA 184 123 .617 26. .950 22. .104 1. .00 29. .42 1SG1426
ATOM 1426 CA ALA 184 122 .979 28. .196 22, .439 1, .00 29. .42 1SG1427
ATOM 1427 CB ALA 184 123, .783 29, .421 21, .969 1, .00 29. .42 1SG1428
ATOM 1428 C ALA 184 121, .657 28, .230 21. .745 1. .00 29. .42 1SG1429
ATOM 1429 O ALA 184 120, .662 28, .708 22. .289 1. .00 29. .42 1SG1430 ATOM 1430 N LEU 185 121,.626 27,.719 20..504 1..00 28..38 1SG1431
ATOM 1431 CA LEU 185 120, .437 27 .690 19, .708 1. .00 28. .38 1SG1432
ATOM 1432 CB LEU 185 120 .738 27 .114 18 .304 1. .00 28, .38 1SG1433
ATOM 1433 CG LEU 185 119. .596 27 .113 17, .261 1, .00 28. .38 1SG1434
ATOM 1434 CD2 LEU 185 118, .347 26, .356 17. .736 1. .00 28. .38 1SG1435
ATOM 1435 CDl LEU 185 120, .103 26 .550 15. .923 1. .00 28. .38 1SG1436
ATOM 1436 C LEU 185 119 .448 26 .818 20 .421 1 .00 28. .38 1SG1437
ATOM 1437 O LEU 185 118, .260 27 .129 20. .477 1. .00 28. .38 1SG1438
ATOM 1438 N ASN 186 119, .929 25, .707 21, .005 1. .00 28. .34 1SG1439
ATOM 1439 CA ASN 186 119, .093 24 .736 21, .653 1, .00 28. .34 1SG1440
ATOM 1440 CB ASN 186 119 .924 23 .606 22 .272 1 .00 28. .34 1SG1441
ATOM 1441 CG ASN 186 120, .776 23 .012 21, .166 1. .00 28. .34 1SG1442
ATOM 1442 ODl ASN 186 120, .545 23, .268 19. .985 1. .00 28. .34 1SG1443
ATOM 1443 ND2 ASN 186 121, .788 22, .191 21. .553 1, .00 28. .34 1SG1444
ATOM 1444 C ASN 186 118 .361 25 .369 22. .794 1. .00 28, .34 1SG1445
ATOM 1445 O ASN 186 117, .161 25 .163 22. .968 1. .00 28, .34 1SG1446
ATOM 1446 N ALA 187 119. .077 26, .170 23. .600 1, .00 29, .57 1SG1447
ATOM 1447 CA ALA 187 118, .516 26, .756 24, .781 1, .00 29. .57 1SG1448
ATOM 1448 CB ALA 187 119 .530 2 .607 25, .564 1, .00 29, .57 1SG1449
ATOM 1449 C ALA 187 117, .373 27, .644 24, .409 1, .00 29. .57 1SG1450
ATOM 1450 O ALA 187 116. .374 27, .698 25 .123 1 .00 29. .57 1SG1451
ATOM 1451 N ASN 188 117. .497 28, .375 23. .288 1, .00 32. .71 1SG1452
ATOM 1452 CA ASN 188 116 .486 29 .304 22. .878 1, .00 32, .71 1SG1453
ATOM 1453 CB ASN 188 116 .870 30 .044 21 .585 1 .00 32, .71 1SG1454
ATOM 1454 CG ASN 188 115, .867 31, .162 21. .338 1 .00 32. .71 1SG1455
ATOM 1455 ODl ASN 188 114. .655 30, .955 21. .361 1, .00 32. .71 1SG1456
ATOM 1456 ND2 ASN 188 116. .392 32 .392 21. .091 1, .00 32. .71 1SG1457
ATOM 1457 C ASN 188 115 .200 28 .579 22 .620 1 .00 32. .71 1SG1458
ATOM 1458 O ASN 188 114, .140 28, .995 23, .079 1. .00 32, .71 1SG1459
ATOM 1459 N LEU 189 115, .265 27, .451 21, .898 1, .00 37. .34 1SG1460
ATOM 1460 CA LEU 189 114 .109 26, .686 21, .521 1, .00 37. .34 1ΞG1461
ATOM 1461 CB LEU 189 114 .433 25 .521 20, .573 1 .00 37, .34 1SG1462
ATOM 1462 CG LEU 189 114, .757 25, .993 19, .146 1, .00 37, .34 1SG1463
ATOM 1463 CD2 LEU 189 115, .862 27, .056 19. .154 1, .00 37. .34 1SG1464
ATOM 1464 CDl LEU 189 113, .498 26, .502 18, .429 1, .00 37. .34 1SG1465
ATOM 1465 C LEU 189 113 .420 26 .120 22 .725 1, .00 37. .34 1SG1466
ATOM 1466 O LEU 189 112, .228 25, .827 22 , .675 1, .00 37. .34 1SG1467
ATOM 1467 N SER 190 114. .163 25. ,887 23. .818 1. .00 41, .01 1SG1468
ATOM 1468 CA SER 190 113, .634 25. .301 25. .020 1, .00 41. .01 1SG1469
ATOM 1469 CB SER 190 114, .737 24. .895 26. .013 1, .00 41. .01 1SG1470
ATOM 1470 OG SER 190 115, .557 23. .883 25, .446 1. .00 41. .01 1SG1471
ATOM 1471 C SER 190 112. .742 26. .279 25. .722 1. .00 41. .01 1SG1472
ATOM 1472 O SER 190 112. .111 25. .935 26. .719 1. .00 41. .01 1SG1473
ATOM 1473 N THR 191 112, .698 27. .534 25, .241 1. .00 45. .21 1SG1474
ATOM 1474 CA THR 191 111, .911 28. .581 25. .825 1. .00 45. .21 1SG1475
ATOM 1475 CB THR 191 112. .214 29. .942 25. .266 1. .00 45. .21 1SG1476
ATOM 1476 OGl THR 191 111. .902 29. .992 23. .882 1. .00 45. .21 1SG1477
ATOM 1477 CG2 THR 191 113. .706 30, .244 25. .493 1. .00 45. .21 1SG1478
ATOM 1478 C THR 191 110. .458 28. .298 25. .601 1. .00 45. .21 1SG1479
ATOM 1479 O THR 191 109. .604 28. .840 26. .300 1. .00 45. .21 1SG1480
ATOM 1480 N LEU 192 110. .141 27. .476 24. ,581 1. ,00 50. .31 1SG1481
ATOM 1481 CA LEU 192 108. . 119 27. .191 24. .226 1. .00 50. .31 1SG1482
ATOM 1482 CB LEU 192 108. .679 26. ,185 23. .065 1. .00 50. .31 1SG1483
ATOM 1483 CG LEU 192 107. .264 26. .031 22. .485 1. .00 50. ,31 1SG1484
ATOM 1484 CD2 LEU 192 107. .202 24. .864 21. .485 1. .00 50. .31 1SG1485
ATOM 1485 CDl LEU 192 106. .773 27. ,358 21. .880 1. ,00 50. .31 1SG1486
ATOM 1486 C LEU 192 108. ,082 26. ,630 25. .437 1. ,00 50. 31 1SG1487 ATOM 1487 O LEU 192 108.650 25.,830 26.,178 1.00 50.31 1SG1488
ATOM 1488 N GLU 193 106. ,824 27. .063 25. .692 1. .00 54. 12 1SG1489
ATOM 1489 CA GLU 193 106. ,173 26. .648 26. .905 1. .00 54. 12 1SG1490
ATOM 1490 CB GLU 193 105. ,055 27. ,601 27. .356 1. 00 54. 12 1SG1491
ATOM 1491 CG GLU 193 105. .564 29. .004 27. .686 1. .00 54. ,12 1SG1492
ATOM 1492 CD GLU 193 105. .678 29. .768 26. .376 1. .00 54. ,12 1SG1493
ATOM 1493 OEl GLU 193 105. ,209 29. .236 25. .335 1. .00 54. 12 1SG1494
ATOM 1494 OE2 GLU 193 106. .231 30. .901 26. .402 1. ,00 54. 12 1SG1495
ATOM 1495 C GLU 193 105. .581 25. .283 26. .754 1. .00 54. ,12 1SG1496
ATOM 1496 O GLU 193 104. .778 25. .043 25. .857 1. .00 54. ,12 1SG1497
ATOM 1497 N VAL 194 106. .030 24. .329 27. .596 1. .00 58. ,28 1SG1498
ATOM 1498 CA VAL 194 105. .476 23. .007 27. .631 1. .00 58. .28 1SG1499
ATOM 1499 CB VAL 194 106. .432 22. .009 28, .218 1. .00 58. .28 1SG1500
ATOM 1500 CGI VAL 194 107. .608 21. .857 27. .243 1. .00 58. .28 1SG1501
ATOM 1501 CG2 VAL 194 106. .888 22. .503 29. .601 1. .00 58. .28 1SG1502
ATOM 1502 C VAL 194 104. .198 22, .978 28. .410 1. .00 58. .28 1SG1503
ATOM 1503 O VAL 194 103, .164 22, .512 27, .935 1. .00 58. .28 1SG1504
ATOM 1504 N LEU 195 104. .246 23. .498 29, .650 1. .00 62. .77 1SG1505
ATOM 1505 CA LEU 195 103. .088 23. .504 30, .486 1. .00 62, .77 1SG1506
ATOM 1506 CB LEU 195 103. .310 22, .751 31, .818 1, .00 62, .77 1SG1507
ATOM 1507 CG LEU 195 102. .090 22, .720 32, .759 1. .00 62, .77 1SG1508
ATOM 1508 CD2 LEU 195 100. .882 22, .089 32 .049 1. .00 62. .77 1SG1509
ATOM 1509 CDl LEU 195 101. .785 24, .094 3 .380 1. .00 62, .77 1SG1510
ATOM 1510 C LEU 195 102. .838 24, .942 30, .767 1. .00 62, .77 1SG1511
ATOM 1511 O LEU 195 103, .528 25, .555 31, .579 1. .00 62. .77 1SG1512
ATOM 1512 N THR 196 101 .828 25, .519 30 .093 1 .00 68 .78 1SG1513
ATOM 1513 CA THR 196 101, .582 26, .912 30, .292 1. .00 68. .78 1SG1514
ATOM 1514 CB THR 196 101. .214 27, .632 29, .026 1. .00 68. .78 1SG1515
ATOM 1515 OGl THR 196 102 .230 27 .437 28 .052 1 .00 68 .78 1SG1516
ATOM 1516 CG2 THR 196 101 .053 29, .133 29 .331 1 .00 68 .78 1SG1517
ATOM 1517 C THR 196 100. .413 27, .014 31, .210 1. .00 68 .78 1SG1518
ATOM 1518 O THR 196 99. .298 26, .637 30. .854 1, .00 68. .78 1SG1519
ATOM 1519 N LYS 197 100 .648 27 .525 32 .434 1, .00 79 .37 1SG1520
ATOM 1520 CA LYS 197 99 .558 27, .659 33 .348 1. .00 79 .37 1SG1521
ATOM 1521 CB LYS 197 99, .944 27, .517 34, .829 1, .00 79, .37 1SG1522
ATOM 1522 CG LYS 197 100 .781 28 .667 35 .376 1 .00 79 .37 1SG1523
ATOM 1523 CD LYS 197 100 .796 28 .718 36 .904 1 .00 79 .37 1SG1524
ATOM 1524 CE LYS 197 99 .397 28 .796 37 .518 1, .00 79 .37 1SG1525
ATOM 1525 NZ LYS 197 98, .822 27, .442 37, .647 1, .00 79, .37 1SG1526
ATOM 1526 C LYS 197 98 .989 29 .021 33 .138 1 .00 79 .37 1SG1527
ATOM 1527 O LYS 197 99 .665 30 .038 33 .283 1 .00 79 .37 1SG1528
ATOM 1528 N ILE 198 97 .730 29, .060 32 .686 1, .00 97, .63 1SG1529
ATOM 1529 CA ILE 198 97 .071 30 .300 32 .420 1 .00 97 .63 1SG1530
ATOM 1530 CB ILE 198 95 .878 30 .140 31 .549 1 .00 97 .63 1SG1531
ATOM 1531 CG2 ILE 198 95 .401 31 .551 31 .217 1. .00 97, .63 1SG1532
ATOM 1532 CGI ILE 198 96 .198 29, .372 30. .272 1, .00 97, .63 1SG1533
ATOM 1533 CDl ILE 198 94 .899 28 .943 29 .589 1 .00 97 .63 1SG1534
ATOM 1534 C ILE 198 96 .581 30 .997 33 .660 1, .00 97, .63 1SG1535
ATOM 1535 O ILE 198 96 .690 32 .218 33 .757 1, .00 97, .63 1SG1536
ATOM 1536 N ASP 199 95 .968 30 .266 34 .623 1 .00112 .44 1SG1537
ATOM 1537 CA ASP 199 95 .339 31 .008 35 .689 1, .00112 .44 1SG1538
ATOM 1538 CB ASP 199 93 .824 31 .113 35 .533 1. .00112. .44 1SG1539
ATOM 1539 CG ASP 199 93 .505 31, .137 34, .064 1, .00112. .44 1SG1540
ATOM 1540 ODl ASP 199 93 .787 32 .162 33 .396 1 .00112 .44 1SG1541
ATOM 1541 OD2 ASP 199 92 .966 30 .099 33 .591 1, .00112 .44 1SG1542
ATOM 1542 C ASP 199 95 .294 30, .154 36, .902 1. .00112, .44 1SG1543
ATOM 1543 O ASP 199 96 .115 29 .266 37 .133 1. .00112 .44 1SG1544 ATOM 1544 N ASN 200 94..202 30..421 37.667 1,.00119.61 1SG1545
ATOM 1545 CA ASN 200 93. .784 29. .592 38 .753 1. .00119 .61 1SG1546
ATOM 1546 CB ASN 200 92, .468 30. .034 39 .412 1. .00119 .61 1SG1547
ATOM 1547 CG ASN 200 92, .402 29 .390 40 .788 1, .00119 .61 1SG1548
ATOM 1548 ODl ASN 200 91, .542 28 .561 41 .081 1 .00119 .61 1SG1549
ATOM 1549 ND2 ASN 200 93. .360 29 .787 41 .667 1 .00119 .61 1SG1550
ATOM 1550 C ASN 200 93 .546 28 .383 37 .938 1 .00119 .61 1SG1551
ATOM 1551 O ASN 200 93. .125 28 .506 36 .793 1 .00119 .61 1SG1552
ATOM 1552 N TYR 201 93. .764 27 .185 38 .470 1, .00117 .93 1SG1553
ATOM 1553 CA TYR 201 94. .170 26 .264 37 .467 1, .00117 .93 1SG1554
ATOM 1554 CB TYR 201 95 .274 25 .264 37 .881 1, .00117 .93 1SG1555
ATOM 1555 CG TYR 201 95. .288 24. .888 39, .321 1. .00117. .93 1SG1556
ATOM 1556 CDl TYR 201 94. .343 24, .072 39, .901 1. .00117. .93 1SG1557
ATOM 1557 CD2 TYR 201 96. .332 25, .346 40, .094 1. .00117, .93 1SG1558
ATOM 1558 CE1 TYR 201 94, .440 23 , .749 41, .240 1. .00117, .93 1SG1559
ATOM 1559 CE2 TYR 201 96, .434 25, .028 41, .424 1, .00117, .93 1SG1560
ATOM 1560 CZ TYR 201 95, .484 24. .225 42, .001 1. .00117, .93 1SG1561
ATOM 1561 OH TYR 201 95, .585 23. .892 43, .368 1. .00117 .93 1SG1562
ATOM 1562 C TYR 201 93, .379 25. .665 36, .377 1. .00117 .93 1SG1563
ATOM 1563 O TYR 201 92. .567 24, .765 36 .521 1, .00117 .93 1SG1564
ATOM 1564 N THR 202 93. .859 26, .114 35 .201 1. .00 99 .50 1SG1565
ATOM 1565 CA THR 202 93, .679 25, .685 33 .858 1. .00 99 .50 1SG1566
ATOM 1566 CB THR 202 92, .729 26, .541 33 .083 1, .00 99 .50 1SG1567
ATOM 1567 OGl THR 202 91, .457 26, .531 33 .712 1 .00 99 .50 1SG1568
ATOM 1568 CG2 THR 202 92, .623 26, .014 31 .642 1, .00 99 .50 1SG1569
ATOM 1569 C THR 202 95, .057 25, .915 33 .299 1 .00 99 .50 1SG1570
ATOM 1570 O THR 202 95, .699 26, .910 33 .637 1, .00 99 .50 1SG1571
ATOM 1571 N LEU 203 95, .567 24, .983 32, .474 1. .00 82 .44 1SG1572
ATOM 1572 CA LEU 203 96, .891 25, .081 31, .920 1, .00 82 .44 1SG1573
ATOM 1573 CB LEU 203 97, .871 24, .110 32, .592 1, .00 82 .44 1SG1574
ATOM 1574 CG LEU 203 97, .808 24, .103 34, .131 1. .00 82 .44 1SG1575
ATOM 1575 CD2 LEU 203 97, .799 25, .513 34 .727 1, .00 82 .44 1SG1576
ATOM 1576 CDl LEU 203 98, .910 23, .204 34, .712 1, .00 82 .44 1SG1577
ATOM 1577 C LEU 203 96, .753 24, .529 30 .539 1, .00 82 .44 1SG1578
ATOM 1578 O LEU 203 95, .752 23, .880 30 .247 1, .00 82 .44 1SG1579
ATOM 1579 N LEU 204 97, .746 24, .777 29 .654 1, .00 70 .37 1SG1580
ATOM 1580 CA LEU 204 97. .715 24, .189 28 .340 1, .00 70 .37 1SG1581
ATOM 1581 CB LEU 204 97, .824 25, .187 27 .169 1, .00 70 .37 1SG1582
ATOM 1582 CG LEU 204 96, .730 26, .261 27, .141 1, .00 70 .37 1SG1583
ATOM 1583 CD2 LEU 204 96, .696 27, .014 25 .799 1, .00 70 .37 1SG1584
ATOM 1584 CDl LEU 204 96, .883 27, .183 28, .349 1, .00 70 .37 1SG1585
ATOM 1585 C LEU 204 98, .931 23, .315 28 .223 1, .00 70 .37 1SG1586
ATOM 1586 O LEU 204 100, .005 23, .668 28, .711 1, .00 70. .37 1SG1587
ATOM 1587 N ASP 205 98. .781 22, .141 27, .573 1, .00 62. .65 1SG1588
ATOM 1588 CA ASP 205 99. .864 21, .210 27, .387 1, .00 62. .65 1SG1589
ATOM 1589 CB ASP 205 99, .429 19, .748 27, .594 1. .00 62, .65 1SG1590
ATOM 1590 CG ASP 205 100, .661 18, .862 27, .551 1, .00 62, .65 1SG1591
ATOM 1591 ODl ASP 205 101. .785 19, .398 27, .355 1, .00 62, .65 1SG1592
ATOM 1592 OD2 ASP 205 100. .488 17, .625 27, .717 1, .00 62, .65 1SG1593
ATOM 1593 C ASP 205 100, .341 21, .318 25. .966 1, .00 62, .65 1SG1594
ATOM 1594 O ASP 205 99, .750 20, .740 25. .057 1, .00 62 , .65 1SG1595
ATOM 1595 N TYR 206 101, .403 22. .117 25. .765 1. .00 63, .39 1SG1596
ATOM 1596 CA TYR 206 102 , .133 22, .398 24. .560 1, .00 63, .39 1SG1597
ATOM 1597 CB TYR 206 102. .763 23. .795 24, .502 1, .00 63. .39 1SG1598
ATOM 1598 CG TYR 206 101. .652 24. .776 24 , .310 1. .00 63, .39 1SG1599
ATOM 1599 CDl TYR 206 100. .866 24. .703 23. .184 1. .00 63, .39 1SG1600
ATOM 1600 CD2 TYR 206 101. .410 25. .788 25. .210 1. .00 63. .39 1SG1601 ATOM 1601 CE1 TYR 206 99..844 25..596 22..965 1..00 63..39 1SG1602
ATOM 1602 CE2 TYR 206 100. .389 26. .687 24. .995 1. .00 63. .39 1SG1603
ATOM 1603 CZ TYR 206 99. .599 26. ,592 23. .873 1. .00 63. .39 1SG1604
ATOM 1604 OH TYR 206 98. .553 27. .510 23. .647 1. .00 63. .39 1SG1605
ATOM 1605 C TYR 206 103. .161 21. .354 24. .215 1. .00 63. .39 1SG1606
ATOM 1606 O TYR 206 103. .892 21. .522 23, .242 1. .00 63. .39 1SG1607
ATOM 1607 N SER 207 103. .391 20. .363 25, .095 1. .00 61. .59 1SG1608
ATOM 1608 CA SER 207 104. .459 19, .409 24, .904 1. .00 61. .59 1SG1609
ATOM 1609 CB SER 207 104. .491 18. .314 25, .983 1. .00 61. .59 1SG1610
ATOM 1610 OG SER 207 105. .564 17. .419 25, .732 1. .00 61. .59 1SG1611
ATOM 1611 C SER 207 104, .410 18, .721 23, .568 1, .00 61. .59 1SG1612
ATOM 1612 O SER 207 103. .348 18. .373 23. .054 1. .00 61. .59 1SG1613
ATOM 1613 N LEU 208 105. .609 18. .506 22. .974 1. .00 57. .04 1SG1614
ATOM 1614 CA LEU 208 105. .735 17. .843 21. .705 1. .00 57. .04 1SG1615
ATOM 1615 CB LEU 208 107, .111 17. .993 21. .032 1. .00 57. .04 1SG1616
ATOM 1616 CG LEU 208 107, .409 19. .416 20. .526 1. .00 57. .04 1SG1617
ATOM 1617 CD2 LEU 208 108, .621 19, .424 19. .581 1. .00 57. .04 1SG1618
ATOM 1618 CDl LEU 208 107, .543 20, .414 21. .688 1, .00 57, .04 1SG1619
ATOM 1619 C LEU 208 105, .470 16. .380 21 .873 1. .00 57, .04 1SG1620
ATOM 1620 O LEU 208 105 .998 15. .728 22 .772 1. .00 57 .04 1SG1621
ATOM 1621 N ILE 209 104 , .580 15. .860 21, .009 1. .00 51, .47 1SG1622
ATOM 1622 CA ILE 209 104 , .170 14. .489 20, .912 1. .00 51, .47 1SG1623
ATOM 1623 CB ILE 209 102, .893 14. .337 20, .140 1. .00 51, .47 1SG1624
ATOM 1624 CG2 ILE 209 102, .657 12 , .841 19, .879 1. .00 51, .47 1SG1625
ATOM 1625 CGI ILE 209 101, .741 15, .029 20, .889 1, .00 51, .47 1SG1626
ATOM 1626 CDl ILE 209 100. .460 15, .165 20, .067 1, .00 51, .47 1SG1627
ATOM 1627 C ILE 209 105. .212 13 , .639 20 .257 1. .00 51, .47 1SG1628
ATOM 1628 O ILE 209 105 .332 12, .460 20 .581 1, .00 51, .47 1SG1629
ATOM 1629 N SER 210 105 .928 14, .189 19 .252 1. .00 43 .78 1SG1630
ATOM 1630 CA SER 210 106. .900 13. .414 18, .531 1. .00 43 , .78 1SG1631
ATOM 1631 CB SER 210 106, .337 12. .780 17, .250 1. .00 43, .78 1SG1632
ATOM 1632 OG SER 210 105, .324 11. .842 17, .578 1, .00 43, .78 1SG1633
ATOM 1633 C SER 210 108. .012 14. .325 18, .112 1. .00 43. .78 1SG1634
ATOM 1634 O SER 210 107. .964 15. .534 18, .331 1, .00 43. .78 1SG1635
ATOM 1635 N SER 211 109, .064 13. .748 17, .495 1, .00 38. .20 1SG1636
ATOM 1636 CA SER 211 110. .191 14. .533 17 .083 1. .00 38. .20 1SG1637
ATOM 1637 CB SER 211 Ill, .403 13 , .684 16 .658 1. .00 38. .20 1SG1638
ATOM 1638 OG SER 211 111 .870 12. .917 17 .759 1, .00 38 .20 1SG1639
ATOM 1639 C SER 211 109, .772 15. .371 15, .917 1, .00 38. .20 1SG1640
ATOM 1640 O SER 211 108 , .845 15. .024 15, .187 1. .00 38. .20 1SG1641
ATOM 1641 N PRO 212 110, .435 16. .484 15, .733 1. .00 37. .02 1SG1642
ATOM 1642 CA PRO 212 110, .091 17. .360 14, .649 1. .00 37. .02 1SG1643
ATOM 1643 CD PRO 212 111. .005 17. .210 16, .857 1. .00 37. .02 1SG1644
ATOM 1644 CB PRO 212 110. .864 18. .654 14, .898 1. .00 37, .02 1SG1645
ATOM 1645 CG PRO 212 111. .009 18. .690 16, .431 1. .00 37. .02 1SG1646
ATOM 1646 C PRO 212 110. .377 16. .709 13, .338 1. .00 37. .02 1SG1647
ATOM 1647 O PRO 212 Ill, .460 16. .150 13, .167 1. .00 37. .02 1SG1648
ATOM 1648 N GLU 213 109, .432 16. .793 12, .385 1. .00 36. .43 1SG1649
ATOM 1649 CA GLU 213 109. .648 16. .148 11, .128 1. .00 36. .43 1SG1650
ATOM 1650 CB GLU 213 108. .423 15. .373 10, .612 1. .00 36. .43 1SG1651
ATOM 1651 CG GLU 213 107. .191 16. .254 10, .400 1. .00 36. .43 1SG1652
ATOM 1652 CD GLU 213 106. .064 15. .367 9, .891 1. .00 36. .43 1SG1653
ATOM 1653 OEl GLU 213 106. .366 14. .245 9, .405 1. .00 36. .43 1SG1654
ATOM 1654 OE2 GLU 213 104. .885 15. .802 9, .977 1. ,00 36. .43 1SG1655
ATOM 1655 C GLU 213 109. .981 17. .192 10, .121 1. .00 36. .43 1SG1656
ATOM 1656 O GLU 213 109. .396 18. .273 10, .100 1. .00 36. .43 1SG1657
ATOM 1657 N ILE 214 110. .955 16. .884 9, .249 1. .00 38. .39 1SG1658 -i o ri CN ro <# m iD -- oo σι θ H CN ro s)i ιinn ιvoo [i-- ccoo cenn oo H cCNN rroo MMii iin iiDD ii-- oooo oon oo riri CCNN rro ^^ii iin vvDD i r-- CcDo ccn o ri rN c ^ in vD C- CD c o ri rN rO Mi i in iD vo vo vo vD iD VD vo vo iD t- t- r- r- t- i- i- t- t- oo cD oo cD co oo oo oo co co en cn cn cn cn en cn cn cn cn o o o o o o
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ATOM 1715 C ASP 220 106.663 19..855 12..776 1..00 45.43 1SG1716
ATOM 1716 O ASP 220 107, .492 19. .005 13. .096 1. .00 45, .43 1SG1717
ATOM 1717 N LEU 221 105 .920 20. .528 13 .682 1, .00 44 .79 1SG1718
ATOM 1718 CA LEU 221 106, .017 20, .262 15 .090 1, .00 44, .79 1SG1719
ATOM 1719 CB LEU 221 106, .385 21. .495 15. .934 1. .00 44, .79 1SG1720
ATOM 1720 CG LEU 221 107 .791 22. .051 15 .650 1. .00 44 .79 1SG1721
ATOM 1721 CD2 LEU 221 108 .854 20. .948 15 .755 1. .00 44 .79 1SG1722
ATOM 1722 CDl LEU 221 108 .105 23, .259 16 .545 1, .00 44 .79 1SG1723
ATOM 1723 C LEU 221 104 .664 19, .813 15 .565 1, .00 44 .79 1SG1724
ATOM 1724 O LEU 221 103, .655 20, .472 15. .315 1. .00 44 .79 1SG1725
ATOM 1725 N ASN 222 104 .613 18, .670 16 .282 1, .00 42 .20 1SG1726
ATOM 1726 CA ASN 222 103, .361 18, .154 16 .764 1, .00 42 .20 1SG1727
ATOM 1727 CB ASN 222 103 .229 16, .634 16 .565 1, .00 42 .20 1SG1728
ATOM 1728 CG ASN 222 103 .310 16, .328 15 .076 1, .00 42 .20 1SG1729
ATOM 1729 ODl ASN 222 104, .377 15, .991 14. .564 1. .00 42, .20 1SG1730
ATOM 1730 ND2 ASN 222 102 .158 16, .439 14 .361 1. .00 42 .20 1SG1731
ATOM 1731 C ASN 222 103 .313 18, .391 18 .245 1. .00 42 .20 1SG1732
ATOM 1732 O ASN 222 104, .247 18. .043 18 .965 1, .00 42 .20 1SG1733
ATOM 1733 N LEU 223 102 .212 19, .001 18 .735 1, .00 42 .37 1SG1734
ATOM 1734 CA LEU 223 102, .077 19, .268 20 .144 1, .00 42 .37 1SG1735
ATOM 1735 CB LEU 223 102 .038 20 .763 20 .494 1. .00 42 .37 1SG1736
ATOM 1736 CG LEU 223 103 .358 21, .491 20 .190 1, .00 42 .37 1SG1737
ATOM 1737 CD2 LEU 223 103. .384 22, .888 20 .829 1, .00 42 .37 1SG1738
ATOM 1738 CDl LEU 223 103 .655 21, .504 18 .681 1, .00 42 .37 1SG1739
ATOM 1739 C LEU 223 100. .790 18, .664 20 .637 1. .00 42 .37 1SG1740
ATOM 1740 O LEU 223 99 .868 18 .430 19 .859 1, .00 42 .37 1SG1741
ATOM 1741 N LYS 224 100, .715 18, .386 21 .959 1, .00 44 .37 1SG1742
ATOM 1742 CA LYS 224 99, .569 17. .779 22 .594 1. .00 44, .37 1SG1743
ATOM 1743 CB LYS 224 99 .805 17, .582 24 .104 1, .00 44 .37 1SG1744
ATOM 1744 CG LYS 224 98, .633 16, .973 24 .880 1, .00 44 .37 1SG1745
ATOM 1745 CD LYS 224 98 .345 15 .500 24 .586 1, .00 44 .37 1SG1746
ATOM 1746 CE LYS 224 97, .186 14, .948 25 .422 1, .00 44 .37 1SG1747
ATOM 1747 NZ LYS 224 96, .842 13, .575 24 .992 1. .00 44 .37 1SG1748
ATOM 1748 C LYS 224 98, .355 18, .655 22 .435 1, .00 44 .37 1SG1749
ATOM 1749 O LYS 224 97, .321 18, .206 21 .942 1. .00 44 .37 1SG1750
ATOM 1750 N GLY 225 98 .455 19, .940 22 .833 1, .00 49 .47 1SG1751
ATOM 1751 CA GLY 225 97, .400 20, .903 22 .634 1. .00 49 .47 1SG1752
ATOM 1752 C GLY 225 96, .120 20. .580 23. .355 1. .00 49, .47 1SG1753
ATOM 1753 O GLY 225 95, .058 20, .533 22 .732 1. .00 49, .47 1SG1754
ATOM 1754 N VAL 226 96, .168 20, .340 24. .681 1. .00 57, .67 1SG1755
ATOM 1755 CA VAL 226 94, .940 20, .130 25. .398 1. .00 57 .67 1SG1756
ATOM 1756 CB VAL 226 94, .671 18. .687 25, .741 1. .00 57, .67 1SG1757
ATOM 1757 CGI VAL 226 95, .774 18. .171 26, .679 1. ,00 57, .67 1SG1758
ATOM 1758 CG2 VAL 226 93, .253 18, .581 26, .328 1. .00 57, .67 1SG1759
ATOM 1759 C VAL 226 95, .029 20. .892 26, .683 1. .00 57. .67 1SG1760
ATOM 1760 O VAL 226 96, .085 20. .936 27, .315 1. .00 57, .67 1SG1761
ATOM 1761 N PHE 227 93, .912 21. .528 27. .099 1. .00 65. .02 1SG1762
ATOM 1762 CA PHE 227 93. .909 22. .185 28. .375 1. ,00 65. .02 1SG1763
ATOM 1763 CB PHE 227 92, .711 23, .108 28, .663 1. .00 65, .02 1SG1764
ATOM 1764 CG PHE 227 92. .910 24. .389 27. .926 1. .00 65. .02 1SG1765
ATOM 1765 CDl PHE 227 92. .813 24, .432 26. .560 1. .00 65, .02 1SG1766
ATOM 1766 CD2 PHE 227 93. .165 25. .566 28. .595 1. .00 65. .02 1SG1767
ATOM 1767 CE1 PHE 227 92. .990 25. .619 25. .889 1. .00 65. .02 1SG1768
ATOM 1768 CE2 PHE 227 93. .342 26. .757 27. .929 1. .00 65. .02 1SG1769
ATOM 1769 CZ PHE 227 93. .259 26. ,786 26. .561 1. .00 65. .02 1SG1770
ATOM 1770 C PHE 227 93. .899 21. .084 29. .379 1. .00 65. .02 1SG1771
ATOM 1771 O PHE 227 93. .326 20. .019 29. .157 1. .00 65. .02 1SG1772 ATOM 1772 N TYR 228 94..570 21,.350 30,.506 1..00 69..96 1SG1773
ATOM 1773 CA TYR 228 94. .937 20, .411 31, .522 1. .00 69. .96 1SG1774
ATOM 1774 CB TYR 228 96. .466 20 .518 31, .419 1. .00 69. .96 1SG1775
ATOM 1775 CG TYR 228 97, .406 19 .802 32 .302 1. .00 69 .96 1SG1776
ATOM 1776 CDl TYR 228 97. .542 20, .109 33. .635 1. .00 69. .96 1SG1777
ATOM 1777 CD2 TYR 228 98. .241 18, .871 31, .731 1. .00 69. .96 1SG1778
ATOM 1778 CE1 TYR 228 98, .480 19 .450 34 .395 1, .00 69 .96 1SG1779
ATOM 1779 CE2 TYR 228 99 .180 18 .211 32 .486 1 .00 69 .96 1SG1780
ATOM 1780 CZ TYR 228 99. .297 18, .500 33, .825 1. .00 69. .96 1SG1781
ATOM 1781 OH TYR 228 00. .263 17, .837 34, .612 1, .00 69, .96 1SG1782
ATOM 1782 C TYR 228 94, .472 20 .954 32 .841 1, .00 69, .96 1SG1783
ATOM 1783 O TYR 228 94, .587 22, .155 33, .075 1. .00 69, .96 1SG1784
ATOM 1784 N PRO 229 93. .817 20, .161 33 .650 1. .00 65 .88 1SG1785
ATOM 1785 CA PRO 229 93. .530 20, .626 34, .992 1. .00 65, .88 1SG1786
ATOM 1786 CD PRO 229 92. .678 19, .457 33 .080 1, .00 65, .88 1SG1787
ATOM 1787 CB PRO 229 92, .141 20, .104 35, .344 1, .00 65, .88 1SG1788
ATOM 1788 CG PRO 229 91 .492 19 .809 33 .983 1, .00 65 .88 1SG1789
ATOM 1789 C PRO 229 94. .551 20 .117 35 .964 1, .00 65, .88 1SG1790
ATOM 1790 O PRO 229 94. .889 18, .936 35, .879 1. .00 65, .88 1SG1791
ATOM 1791 N LEU 230 95. .039 20 .951 36. .906 1. .00 57, .76 1SG1792
ATOM 1792 CA LEU 230 95 .929 20 .429 37 .905 1 .00 57 .76 1SG1793
ATOM 1793 CB LEU 230 96. .696 21. .526 38 , ,660 1. .00 57, .76 1SG1794
ATOM 1794 CG LEU 230 97, .821 20. .976 39. .555 1, .00 57, .76 1SG1795
ATOM 1795 CD2 LEU 230 98, .227 21 .987 40 .638 1. .00 57 .76 1SG1796
ATOM 1796 CDl LEU 230 99 .002 20 .468 38 .707 1 .00 57 .76 1SG1797
ATOM 1797 C LEU 230 95, .122 19. .666 38. .917 1. .00 57, .76 1SG1798
ATOM 1798 O LEU 230 95, .510 18, .580 39. .350 1. .00 57. .76 1SG1799
ATOM 1799 N GLU 231 93, .953 20 .234 39. .301 1, .00 47 .44 1SG1800
ATOM 1800 CA GLU 231 93, .135 19. .703 40, ,362 1, .00 47, .44 1SG1801
ATOM 1801 CB GLU 231 91. .819 20. .478 40, .573 1, .00 47 .44 1SG1802
ATOM 1802 CG GLU 231 91. .958 21. .907 41, ,102 1, .00 47, .44 1SG1803
ATOM 1803 CD GLU 231 90, .546 22 .411 41, ,372 1 .00 47 .44 1SG1804
ATOM 1804 OEl GLU 231 89, .876 21. .801 42 , .249 1. .00 47. .44 1SG1805
ATOM 1805 OE2 GLU 231 90. .111 23 , .391 40, .713 1. .00 47 .44 1SG1806
ATOM 1806 C GLU 231 92. .719 18. .304 40, .050 1, .00 47. .44 1SG1807
ATOM 1807 O GLU 231 92. .875 17. .422 40. .894 1. .00 47. .44 1SG1808
ATOM 1808 N ASN 232 92. .181 18. .047 38. .842 1, .00 37. .97 1SG1809
ATOM 1809 CA ASN 232 91. .781 16 , .700 38. .539 1, .00 37. .97 1SG1810
ATOM 1810 CB ASN 232 90, .265 16, .446 38. .575 1. .00 37, .97 1SG1811
ATOM 1811 CG ASN 232 89. .786 16, .391 40. .014 1. .00 37. .97 1SG1812
ATOM 1812 ODl ASN 232 90. .577 16, .347 40. .953 1. .00 37. .97 1SG1813
ATOM 1813 ND2 ASN 232 88. .441 16, .372 40, .206 1, .00 37, .97 1SG1814
ATOM 1814 C ASN 232 92. ,190 16. .396 37. .136 1. .00 37. ,97 1SG1815
ATOM 1815 O ASN 232 92, .240 17. .279 36. .282 1. .00 37. .97 1SG1816
ATOM 1816 N LEU 233 92, .477 15, .110 36, .868 1. .00 34. .24 1SG1817
ATOM 1817 CA LEU 233 92, .923 14, .686 35, .575 1, .00 34, .24 1SG1818
ATOM 1818 CB LEU 233 93. .838 13. ,456 35. ,659 1. .00 34. .24 1SG1819
ATOM 1819 CG LEU 233 94. .864 13. .478 36. .806 1. .00 34. .24 1SG1820
ATOM 1820 CD2 LEU 233 95, .681 14. .774 36. .840 1. .00 34. .24 1SG1821
ATOM 1821 CDl LEU 233 95. .729 12. .209 36. .790 1. ,00 34. .24 1SG1822
ATOM 1822 C LEU 233 91. .717 14. .104 34. .906 1. .00 34. .24 1SG1823
ATOM 1823 O LEU 233 91. .137 13. ,149 35, ,420 1. .00 34. ,24 1SG1824
ATOM 1824 N THR 234 91. .292 14. .649 33. .753 1. ,00 34. .10 1SG1825
ATOM 1825 CA THR 234 90. .191 14. ,012 33. .095 1. ,00 34. ,10 1SG1826
ATOM 1826 CB THR 234 88. .878 14. .700 33. .326 1. .00 34. .10 1SG1827
ATOM 1827 OGl THR 234 88. .610 14. ,768 34. .719 1. .00 34. .10 1SG1828
ATOM 1828 CG2 THR 234 87. .766 13. ,903 32. 619 1. 00 34. .10 1SG1829 ATOM 1829 C THR 234 90..479 14..065 31..630 1..00 34..10 1SG1830
ATOM 1830 O THR 234 90. .771 15. .131 31. .091 1. .00 34. .10 1SG1831
ATOM 1831 N ASP 235 90. .417 12. .906 30. .946 1. .00 37. .14 1SG1832
ATOM 1832 CA ASP 235 90. .682 12 .885 29 .536 1. .00 37, .14 1SG1833
ATOM 1833 CB ASP 235 91. ,080 11, .499 29. .006 1. .00 37. .14 1SG1834
ATOM 1834 CG ASP 235 92. .472 11, .194 29. .533 1. .00 37. .14 1SG1835
ATOM 1835 ODl ASP 235 93. .324 12 .122 29 .520 1, .00 37. .14 1SG1836
ATOM 1836 OD2 ASP 235 92. .701 10 .033 29 .965 1. .00 37 .14 1SG1837
ATOM 1837 C ASP 235 89. .446 13, .318 28. .815 1. .00 37. .14 1SG1838
ATOM 1838 O ASP 235 88. .329 13, .187 29. .312 1. .00 37. .14 1SG1839
ATOM 1839 N PRO 236 89. .653 13, .857 27 .644 1. .00 41 .45 1SG1840
ATOM 1840 CA PRO 236 88. .537 14, .295 26, .847 1. .00 41, .45 1SG1841
ATOM 1841 CD PRO 236 90. .809 14 , .720 27, .460 1. .00 41 .45 1SG1842
ATOM 1842 CB PRO 236 89. .104 15, .274 25 .823 1. .00 41, .45 1SG1843
ATOM 1843 CG PRO 236 90, .343 15 .851 26 .529 1. .00 41 .45 1SG1844
ATOM 1844 C PRO 236 87, .787 13, .152 26 .232 1. .00 41, .45 1SG1845
ATOM 1845 O PRO 236 88. .381 12 .118 25 .936 1. .00 41 .45 1SG1846
ATOM 1846 N PRO 237 86, .516 13, .346 26 .029 1. .00 46 .09 1SG1847
ATOM 1847 CA PRO 237 85. .667 12, .330 25 .462 1. .00 46, .09 1SG1848
ATOM 1848 CD PRO 237 85. .778 14 .241 26 .909 1, .00 46 .09 1SG1849
ATOM 1849 CB PRO 237 84. .235 12 .789 25 .732 1 .00 46 .09 1SG1850
ATOM 1850 CG PRO 237 84. .357 13 .664 26, .991 1. .00 46, .09 1SG1851
ATOM 1851 C PRO 237 85. .936 12, .089 24, .009 1, .00 46 .09 1SG1852
ATOM 1852 O PRO 237 85, .309 11 .200 23 .437 1, .00 46 .09 1SG1853
ATOM 1853 N PHE 238 86 .820 12 .876 2 .373 1 .00 47 .91 1SG1854
ATOM 1854 CA PHE 238 87. .011 12, .742 21, .958 1. .00 47, .91 1SG1855
ATOM 1855 CB PHE 238 86, .163 13, .772 21 .201 1, .00 47 .91 1SG1856
ATOM 1856 CG PHE 238 86, .177 14 .986 2 .064 1. .00 47 .91 1SG1857
ATOM 1857 CDl PHE 238 87, .179 15 .926 22 .Oil 1, .00 47 .91 1SG1858
ATOM 1858 CD2 PHE 238 85. .148 15, .157 22, .963 1, .00 47 .91 1SG1859
ATOM 1859 CE1 PHE 238 87, .137 17 .026 2 .839 1, .00 47 .91 1SG1860
ATOM 1860 CE2 PHE 238 85, .101 16 .250 23 .790 1, .00 47 .91 1SG1861
ATOM 1861 CZ PHE 238 86, .101 17 .189 2 .728 1, .00 47 .91 1SG1862
ATOM 1862 C PHE 238 88. .457 12, .829 21, .574 1 .00 47 .91 1SG1863
ATOM 1863 O PHE 238 89, .329 13 .040 2 .415 1, .00 47 .91 1SG1864
ATOM 1864 N SER 239 88, .742 12 .612 20 .270 1, .00 47 .97 1SG1865
ATOM 1865 CA SER 239 90, .093 12 .602 19 .783 1, .00 47 .97 1SG1866
ATOM 1866 CB SER 239 90. .454 11, .314 19 .028 1 .00 47 .97 1SG1867
ATOM 1867 OG SER 239 90, .367 10 .205 19 .909 1, .00 47 .97 1SG1868
ATOM 1868 C SER 239 90, .268 13, .743 18, .832 1, .00 47, .97 1SG1869
ATOM 1869 O SER 239 89, .316 14 .263 18 .251 1, .00 47 .97 1SG1870
ATOM 1870 N PRO 240 91 .501 14 .150 18 .702 1 .00 47 .35 1SG1871
ATOM 1871 CA PRO 240 91. .841 15, .248 17. .837 1. ,00 47. .35 1SG1872
ATOM 1872 CD PRO 240 92, .446 14, .007 19. .792 1. .00 47. .35 1SG1873
ATOM 1873 CB PRO 240 93, .223 15 .730 18. .276 1. .00 47 .35 1SG1874
ATOM 1874 CG PRO 240 93 .727 14 .645 19 .245 1, .00 47 .35 1SG1875
ATOM 1875 C PRO 240 91. .747 14, .856 16. .397 1. ,00 47, .35 1SG1876
ATOM 1876 O PRO 240 91. .958 13, .688 16, .081 1. .00 47, .35 1SG1877
ATOM 1877 N VAL 241 91 .428 15 .820 15 .510 1, .00 44 .30 1SG1878
ATOM 1878 CA VAL 241 91. .283 15, .547 14 , .107 1. .00 44, .30 1SG1879
ATOM 1879 CB VAL 241 90. .420 16, .545 13. .391 1. .00 44, .30 1SG1880
ATOM 1880 CGI VAL 241 91, .099 17. .922 13. .497 1. .00 44, .30 1SG1881
ATOM 1881 CG2 VAL 241 90, .208 16 .068 11. .942 1, .00 44, .30 1SG1882
ATOM 1882 C VAL 241 92, .628 15. .610 13. .465 1. .00 44, .30 1SG1883
ATOM 1883 O VAL 241 93 , .540 16 .258 13. .974 1. .00 44, .30 1SG1884
ATOM 1884 N PRO 242 92. .803 14. .898 12. .384 1. .00 42, .46 1SG1885
ATOM 1885 CA PRO 242 94. .029 15. .007 11. .651 1. ,00 42. .46 1SG1886 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H lO VO VO VO VO VO VO lO VO VD lD VD VO VO VO VD VD VO VD VD VO VO VO VO VD VD VO VO VO lO VO VO lO VO lD VD V \DO VUOJ VVOL) li_Oi Vi_Dl llD llD-i O_OJ C_Oj O_OJ OUOu 00 00 C0 00 00 C0 00 00 00 00 it* ifc it* J lAJ l*J lAJ lA) W > W _J O- t t tO tO K) t t t t t H H H H H H H H H H H H OO OO OO OO OO OO OO OO OO OO lVOD lVDD VVDD VVOD VD VD VO VD VD VD OO OO OO CO t H θ o oo -J c ι ι& iΛ -J H θ io αo -J cn m ιti > . H O VO 00 ^o cn σi ιf^ - tθ H θ io θ- -j σ m ιf>. -J tθ H o ιo oo ~j σι ιπ. ιf' -J tθ H o ιo co -o o oanπonao pp n n Ω Ω Ω Ω Ω Ω Ω Ω Ω O O a P Ω Ω O Ω M σ Ω ro > n M MoonΩpoa a P Ω O O O Ω a O O Ω m a to H ro p n o o n o a Ω D H tDo Ω ω > Ω Ω tD > N t_ M D Ω _- > Ω CD D to H to H to H te te ta - _ te to to ta ta Ω Ω Ω Ω Ω Ω Ω Ω Ω ^ ^ O W O 'O O tH tr, tH _^ _H |-< _H _H < < >α >d ^ ' ^ O ^ ^ W W X Ω > Ωt XΩ' Ωr1 )ΩX Ωr3 ΩX ΩV VΩ xΩ' αr α-< tα< tc< tα* tα1 ct, -)< FC VP P3 P P P α σ α α c α c r - cH CH - tH - t. t. M H t. M M M .. „C. _C_. _... P_ P _ P _ P _ P _
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H H H H H H H H H H H H H H H Η H w _ cn _ _ _ _ _ w w _ iΛ CD W - ^ - -ι (n _ _ - _ι _ cn _ iΛ W cn w -ι ω n _ι w cΩ cn -^ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ώ Ω Ω Ω Ώ Ω Ω Ώ Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ώ Ω Ω Ω Ώ Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω r- r- H t-y t-y H >- H H H H H H H H H t- - H H H H H
ID VO VO lO VO VD VO VO VO VO VO lO VO VO VO VO VD VO lO VD VD VO lO lO VO lD VO VO VO VO VD VO VD VO VO lO VD VO lO VO VO VO lO VD OO CD ro if- it- it- il_ _J _J I _J _J l- - li- - W t tO tO t t t tO t t tO H i- H O O O O O O O O O O V0 V0 V0 VD V0 VD V0 V0 VD VD 00 00 00 w w μ o ιo aι j ιιι uι * w „ μ o ιi) i» 'J θ\ uι * w w μ o iD i» ^ ιιι uι * w ι μ o iD ai i oι uι iι w ι μ o ιo cD >ι oι uι * ω M μ o iD iιι ^
ATOM 1943 O ARG 248 103,.930 28,.166 3..970 1..00 35..97 1SG1944
ATOM 1944 N SER 249 103, .838 29, .540 2. .182 1. .00 34. .32 1SG1945
ATOM 1945 CA SER 249 105, .001 30, .251 2, .626 1. .00 34. .32 1SG1946
ATOM 1946 CB SER 249 106, .205 30, .075 1, .685 1. .00 34. .32 1SG1947
ATOM 1947 OG SER 249 105, .919 30, .642 0 .415 1, .00 34, .32 1SG1948
ATOM 1948 C SER 249 104 .673 31 .710 2 .648 1. .00 34, .32 1SG1949
ATOM 1949 O SER 249 105 .552 32 .554 2 .479 1. .00 34, .32 1SG1950
ATOM 1950 N ASN 250 103 .388 32, .044 2 .865 1. .00 34, .63 1SG1951
ATOM 1951 CA ASN 250 102, .985 33, .418 2 .934 1. .00 34. .63 1SG1952
ATOM 1952 CB ASN 250 101, .459 33, .602 2. .907 1. .00 34. .63 1SG1953
ATOM 1953 CG ASN 250 100, .974 33, .207 1, .520 1. .00 34. .63 1SG1954
ATOM 1954 ODl ASN 250 101 .740 32 .683 0 .713 1. .00 34. .63 1SG1955
ATOM 1955 ND2 ASN 250 99 .669 33 .464 1 .232 1. .00 34. .63 1SG1956
ATOM 1956 C ASN 250 103 .493 33 .998 4, .215 1. .00 34. .63 1SG1957
ATOM 1957 O ASN 250 103 .945 35 .142 4 .254 1. .00 34. .63 1SG1958
ATOM 1958 N SER 251 103, .424 33, .205 5, .305 1. .00 37. .51 1SG1959
ATOM 1959 CA SER 251 103, .832 33, .670 6, .599 1. .00 37. .51 1SG1960
ATOM 1960 CB SER 251 102 .700 33 .664 7 .639 1. .00 37. .51 1SG1961
ATOM 1961 OG SER 251 101 .679 34 .574 7 .256 1. .00 37, .51 1SG1962
ATOM 1962 C SER 251 104 .897 32 .747 7 .106 1, .00 37, .51 1SG1963
ATOM 1963 O SER 251 105, .156 31 .696 6 .524 1. .00 37, .51 1SG1964
ATOM 1964 N MET 252 105 .589 33 .173 8 .182 1. .00 41, .75 1SG1965
ATOM 1965 CA MET 252 106, .660 32, .423 8 .777 1. .00 41. .75 1SG1966
ATOM 1966 CB MET 252 107, .337 33, .207 9 .915 1. .00 41. .75 1SG1967
ATOM 1967 CG MET 252 107 .981 34 .529 9 .492 1. .00 41 .75 1SG1968
ATOM 1968 SD MET 252 109 .579 34 .382 8 .639 1, .00 41. .75 1SG1969
ATOM 1969 CE MET 252 109 .978 36 .147 8 .793 1. .00 41, .75 1SG1970
ATOM 1970 C MET 252 106. .166 31 .146 9 .407 1. .00 41, .75 1SG1971
ATOM 1971 O MET 252 106, .728 30 .079 9 .168 1. .00 41, .75 1SG1972
ATOM 1972 N LEU 253 105, .093 31, .220 10, .227 1. .00 45. .09 1SG1973
ATOM 1973 CA LEU 253 104 .676 30 .062 10 .979 1. .00 45. .09 1SG1974
ATOM 1974 CB LEU 253 105 .012 30 .222 12 .481 1. .00 45, .09 1SG1975
ATOM 1975 CG LEU 253 104 .622 29 .061 13 .419 1. .00 45, .09 1SG1976
ATOM 1976 CD2 LEU 253 105, .223 27 .732 12 .937 1. .00 45, .09 1SG1977
ATOM 1977 CDl LEU 253 103, .108 28 .994 13 .666 1. .00 45, .09 1SG1978
ATOM 1978 C LEU 253 103, .196 29, .866 10 .831 1. .00 45. .09 1SG1979
ATOM 1979 O LEU 253 102, .453 30, .822 10 .622 1. .00 45. .09 1SG1980
ATOM 1980 N TYR 254 102 .731 28 .596 10 .906 1. .00 45. .94 1SG1981
ATOM 1981 CA TYR 254 101 .322 28 .327 10 .817 1. .00 45. .94 1SG1982
ATOM 1982 CB TYR 254 100 .909 27 .583 9 .533 1, .00 45. .94 1SG1983
ATOM 1983 CG TYR 254 101, .337 28, .376 8 .344 1. .00 45. .94 1SG1984
ATOM 1984 CDl TYR 254 100. .727 29, .565 8, .019 1. .00 45. .94 1SG1985
ATOM 1985 CD2 TYR 254 102, .344 27. .907 7, .532 1. .00 45. .94 1SG1986
ATOM 1986 CE1 TYR 254 101 .127 30 .282 6 .915 1. .00 45, .94 1SG1987
ATOM 1987 CE2 TYR 254 102, .748 28 .619 6 .426 1. .00 45, .94 1SG1988
ATOM 1988 CZ TYR 254 102, .141 29 .811 6, .116 1. .00 45. .94 1SG1989
ATOM 1989 OH TYR 254 102, .552 30. .544 4, .982 1. .00 45. .94 1SG1990
ATOM 1990 C TYR 254 100, .952 27. .418 11, .952 1. .00 45. .94 1SG1991
ATOM 1991 O TYR 254 101, .675 26. .473 12, .263 1. .00 45. .94 1SG1992
ATOM 1992 N ILE 255 99, .802 27. .675 12 , .610 1. ,00 43. ,95 1SG1993
ATOM 1993 CA ILE 255 99, .405 26 .801 13 .676 1. .00 43. .95 1SG1994
ATOM 1994 CB ILE 255 99, .457 27 .415 15, .050 1. .00 43. .95 1SG1995
ATOM 1995 CG2 ILE 255 100, .932 27, .718 15, .363 1. .00 43. ,95 1SG1996
ATOM 1996 CGI ILE 255 98. .515 28, .626 15, .172 1. .00 43. .95 1SG1997
ATOM 1997 CDl ILE 255 98. .868 29, .785 14 , .242 1. ,00 43. .95 1SG1998
ATOM 1998 C ILE 255 98. .019 26. .317 13. .411 1. ,00 43. 95 1SG1999
ATOM 1999 O ILE 255 97. .166 27, .049 12. .912 1. .00 43. ,95 1SG2000 ATOM 2000 N GLY 256 97..774 25..031 13..723 1..00 40..03 1SG2001
ATOM 2001 CA GLY 256 96. .466 24. .486 13. .532 1. .00 40. .03 1SG2002
ATOM 2002 C GLY 256 95. .912 24. .240 14. .898 1. ,00 40. .03 1SG2003
ATOM 2003 O GLY 256 96. .392 23. .373 15, .629 1. .00 40. .03 1SG2004
ATOM 2004 N ILE 257 94. .856 24. .993 15. .263 1. ,00 38. .74 1SG2005
ATOM 2005 CA ILE 257 94. .266 24. .833 16. .558 1. .00 38. .74 1SG2006
ATOM 2006 CB ILE 257 93. .787 26. .119 17, .182 1. .00 38. .74 1SG2007
ATOM 2007 CG2 ILE 257 93, .148 25. .758 18, .534 1, .00 38. .74 1SG2008
ATOM 2008 CGI ILE 257 94. .933 27. .134 17, .303 1, .00 38, .74 1SG2009
ATOM 2009 CDl ILE 257 94, .468 28. .565 17, .566 1, .00 38, .74 1SG2010
ATOM 2010 C ILE 257 93, .035 24, .010 16 .359 1, .00 38, .74 1SG2011
ATOM 2011 O ILE 257 92, .034 24. .486 15, .825 1. .00 38, .74 1SG2012
ATOM 2012 N ALA 258 93. .085 22. .747 16. .817 1. .00 40, .59 1SG2013
ATOM 2013 CA ALA 258 91. .993 21. .827 16. .667 1. .00 40. .59 1SG2014
ATOM 2014 CB ALA 258 92. .309 20. .411 17. .158 1. .00 40, .59 1SG2015
ATOM 2015 C ALA 258 90, .860 22, .248 17, .541 1. .00 40, .59 1SG2016
ATOM 2016 O ALA 258 91, .035 23. .003 18 .495 1, .00 40 .59 1SG2017
ATOM 2017 N GLU 259 89, .652 21, .744 17, .209 1, .00 45, .90 1SG2018
ATOM 2018 CA GLU 259 88, .476 21, .995 17 .989 1, .00 45 .90 1SG2019
ATOM 2019 CB GLU 259 87 .150 21 .540 17 .345 1 .00 45 .90 1SG2020
ATOM 2020 CG GLU 259 87, .023 20, .043 17 .068 1, .00 45 .90 1SG2021
ATOM 2021 CD GLU 259 85. .641 19. .823 16, .467 1. .00 45, .90 1SG2022
ATOM 2022 OEl GLU 259 85. .498 19. .930 15, .219 1. .00 45, .90 1SG2023
ATOM 2023 OE2 GLU 259 84, .700 19. .552 17, .260 1. .00 45 .90 1SG2024
ATOM 2024 C GLU 259 88 .651 21. .304 19 .304 1. .00 45 .90 1SG2025
ATOM 2025 O GLU 259 88, .128 21. .754 20, .320 1. .00 45 .90 1SG2026
ATOM 2026 N TYR 260 89, .416 20. .194 19 .306 1, .00 52 .49 1SG2027
ATOM 2027 CA TYR 260 89 .719 19 .397 20 .466 1. .00 52 .49 1SG2028
ATOM 2028 CB TYR 260 90 .677 18 .257 20 .060 1, .00 52 .49 1SG2029
ATOM 2029 CG TYR 260 91. .226 17. .525 21, .232 1. .00 52 .49 1SG2030
ATOM 2030 CDl TYR 260 92. .385 17. .962 21, .831 1. .00 52, .49 1SG2031
ATOM 2031 CD2 TYR 260 90. .605 16. .395 21, .716 1. .00 52 .49 1SG2032
ATOM 2032 CE1 TYR 260 92 .905 17 .283 22 .907 1, .00 52 .49 1SG2033
ATOM 2033 CE2 TYR 260 91. .122 15, .716 22, .791 1. .00 52 .49 1SG2034
ATOM 2034 CZ TYR 260 92. .274 16, .160 23 .390 1. .00 52 .49 1SG2035
ATOM 2035 OH TYR 260 92, .802 15 .458 24 .494 1, .00 52 .49 1SG2036
ATOM 2036 C TYR 260 90 .393 20 .316 21 .441 1. .00 52 .49 1SG2037
ATOM 2037 O TYR 260 90, .103 20, .313 22 .637 1, .00 52 .49 1SG2038
ATOM 2038 N PHE 261 91. .285 21. .171 20, .914 1. .00 56, .44 1SG2039
ATOM 2039 CA PHE 261 92. .021 22. .114 21, .704 1. .00 56, .44 1SG2040
ATOM 2040 CB PHE 261 92. .727 . . 23, .129 20, .779 1, .00 56, .44 1SG2041
ATOM 2041 CG PHE 261 93. .627 24, .090 21 .496 1. .00 56 .44 1SG2042
ATOM 2042 CDl PHE 261 93. .215 24, .888 22, .543 1. .00 56, .44 1SG2043
ATOM 2043 CD2 PHE 261 94, .916 24, .253 21 .055 1. .00 56, .44 1SG2044
ATOM 2044 CE1 PHE 261 94, .075 25 .774 23 .149 1, .00 56 .44 1SG2045
ATOM 2045 CE2 PHE 261 95 .782 25 .138 21 .649 1, .00 56 .44 1SG2046
ATOM 2046 CZ PHE 261 95, .368 25, .900 22 .710 1. .00 56, .44 1SG2047
ATOM 2047 C PHE 261 91. .024 22, .940 22. .460 1. .00 56, .44 1SG2048
ATOM 2048 O PHE 261 91. .056 22, .986 23. .691 1. .00 56, .44 1SG2049
ATOM 2049 N PHE 262 90. .107 23 .595 21, .713 1. .00 55, .54 1SG2050
ATOM 2050 CA PHE 262 89. .122 24 , .498 22. .252 1. .00 55, .54 1SG2051
ATOM 2051 CB PHE 262 88. .137 25, .123 21. .239 1. .00 55, .54 1SG2052
ATOM 2052 CG PHE 262 88. .623 26, .399 20. .642 1. .00 55, .54 1SG2053
ATOM 2053 CDl PHE 262 89, .719 27, .064 21 .137 1. .00 55, .54 1SG2054
ATOM 2054 CD2 PHE 262 87. .908 26, .984 19 .621 1. .00 55 .54 1SG2055
ATOM 2055 CE1 PHE 262 90. .119 28, .253 20. .574 1. .00 55, .54 1SG2056
ATOM 2056 CE2 PHE 262 88. .298 28, .173 19. .057 1. .00 55. .54 1SG2057 ATOM 2057 CZ PHE 262 89..419 28.,805 19..527 1..00 55..54 1SG2058
ATOM 2058 C PHE 262 88. .195 23. .793 23. .180 1. .00 55, .54 1SG2059
ATOM 2059 O PHE 262 87. .821 24. .335 24. .217 1. .00 55. .54 1SG2060
ATOM 2060 N LYS 263 87. ,771 22. ,579 22. ,797 1. .00 50. .11 1SG2061
ATOM 2061 CA LYS 263 86, .805 21. .810 23, .530 1. .00 50 .11 1SG2062
ATOM 2062 CB LYS 263 86. .612 20. .420 22. .889 1, .00 50. .11 1SG2063
ATOM 2063 CG LYS 263 85. .908 20. .384 21. .526 1. .00 50, .11 1SG2064
ATOM 2064 CD LYS 263 84. ,379 20. ,360 21. .589 1. .00 50. .11 1SG2065
ATOM 2065 CE LYS 263 83, .861 18. .964 21, .945 1. .00 50 .11 1SG2066
ATOM 2066 NZ LYS 263 82, .406 18. .855 21, .733 1. .00 50, .11 1SG2067
ATOM 2067 C LYS 263 87. .332 21. .531 24. .902 1. .00 50, .11 1SG2068
ATOM 2068 O LYS 263 86, .598 21. .622 25. .884 1, .00 50, .11 1SG2069
ATOM 2069 N SER 264 88. .625 21. .172 25, .000 1. .00 43 .22 1SG2070
ATOM 2070 CA SER 264 89, .192 20, .764 26. .255 1. .00 43, .22 1SG2071
ATOM 2071 CB SER 264 90. .669 20. .342 26. .141 1. .00 43, .22 1SG2072
ATOM 2072 OG SER 264 91. .479 21. .449 25. .773 1, .00 43, .22 1SG2073
ATOM 2073 C SER 264 89. .110 21. .887 27. .233 1 .00 43 .22 1SG2074
ATOM 2074 O SER 264 88. .975 21. .660 28. .435 1. .00 43 .22 1SG2075
ATOM 2075 N ALA 265 89. .201 23 , .135 26. .745 1 .00 37 .46 1SG2076
ATOM 2076 CA ALA 265 89. .156 24. .258 27, .633 1. .00 37 .46 1SG2077
ATOM 2077 CB ALA 265 89. .355 25. .599 26. .906 1. .00 37 .46 1SG2078
ATOM 2078 C ALA 265 87, .825 24. .304 28, .314 1, .00 37 .46 1SG2079
ATOM 2079 O ALA 265. 87, .743 24, .523 29, .523 1 .00 37 .46 1SG2080
ATOM 2080 N SER 266* 86. .743 24. .077 27, .546 1. .00 35 .61 1SG2081
ATOM 2081 CA SER 266 85. .418 24. .177 28. .081 1. .00 35. .61 1SG2082
ATOM 2082 CB SER 266 84, .321 23. .966 27 .019 1 .00 35 .61 1SG2083
ATOM 2083 OG SER 266 84, .317 22, .624 26. .554 1 .00 35 .61 1SG2084
ATOM 2084 C SER 266 85. .233 23. .148 29. .146 1. .00 35 .61 1SG2085
ATOM 2085 O SER 266 84. .644 23. .429 30. .188 1 .00 35 .61 1SG2086
ATOM 2086 N PHE 267 85, .740 21, .924 28 .908 1 .00 36 .82 1SG2087
ATOM 2087 CA PHE 267 85, .556 20, .853 29. .843 1 .00 36 .82 1SG2088
ATOM 2088 CB PHE 267 86. .104 19. .507 29. .339 1, .00 36 .82 1SG2089
ATOM 2089 CG PHE 267 85. .728 18. .468 30. .342 1 .00 36 .82 1SG2090
ATOM 2090 CDl PHE 267 86. .505 18. .244 31 .456 1 .00 36 .82 1SG2091
ATOM 2091 CD2 PHE 267 84, .588 17. .715 30. .167 1. .00 36 .82 1SG2092
ATOM 2092 CE1 PHE 267 86, .150 17, .282 32. .374 1 .00 36 .82 1SG2093
ATOM 2093 CE2 PHE 267 84, .228 16, .753 31, .081 1, .00 36 .82 1SG2094
ATOM 2094 CZ PHE 267 85. .010 16. .536 32. .190 1 .00 36 .82 1SG2095
ATOM 2095 C PHE 267 86. .256 21. .172 31, .125 1, .00 36 .82 1SG2096
ATOM 2096 O PHE 267 85, .697 20, .982 32, .204 1 .00 36 .82 1SG2097
ATOM 2097 N ALA 268 87. .505 21. .667 31, .035 1, .00 39 .24 1SG2098
ATOM 2098 CA ALA 268 88. .306 21. .943 32. .196 1. .00 39. .24 1SG2099
ATOM 2099 CB ALA 268 89 .719 22. .436 31 .837 1 .00 39 .24 1SG2100
ATOM 2100 C ALA 268 87, .672 23, .007 33. .040 1, .00 39 .24 1SG2101
ATOM 2101 O ALA 268 87. .658 22. .908 34. .266 1, .00 39. .24 1SG2102
ATOM 2102 N HIS 269 87. .150 24. .072 32. .410 1. .00 42. .02 1SG2103
ATOM 2103 CA HIS 269 86. .577 25. .163 33. .149 1 .00 42 .02 1SG2104
ATOM 2104 NDl HIS 269 84. .326 27, .672 33, .322 1. .00 42, .02 1SG2105
ATOM 2105 CG HIS 269 85. .656 27. .527 32, .996 1. .00 42, .02 1SG2106
ATOM 2106 CB HIS 269 86, .217 26. .357 32, .245 1. .00 42, .02 1SG2107
ATOM 2107 NE2 HIS 269 85. .374 29. .464 34, .118 1 .00 42 .02 1SG2108
ATOM 2108 CD2 HIS 269 86. .282 28. .630 33, .489 1. .00 42, .02 1SG2109
ATOM 2109 CE1 HIS 269 84. .213 28. .846 33. .992 1. .00 42. .02 1SG2110
ATOM 2110 C HIS 269 85. .321 24. .719 33. .840 1, .00 42. .02 1SG2111
ATOM 2111 O HIS 269 85. .049 25. .119 34. .972 1. .00 42. .02 1SG2112
ATOM 2112 N PHE 270 84. .510 23. .899 33. .147 1. .00 42, .41 1SG2113
ATOM 2113 CA PHE 270 83. .232 23. .445 33. .624 1. .00 42 .41 1SG2114 ATOM 2114 CB PHE 270 82..533 22..601 32..542 1..00 42..41 1SG2115
ATOM 2115 CG PHE 270 81. .187 22. .165 33. .005 1. .00 42. .41 1SG2116
ATOM 2116 CDl PHE 270 81. .040 21. .069 33. .824 1. .00 42. .41 1SG2117
ATOM 2117 CD2 PHE 270 80. .065 22 , .848 32. .597 1. .00 42, .41 1SG2118
ATOM 2118 CE1 PHE 270 79. .792 20. .670 34. .240 1. .00 42. .41 1SG2119
ATOM 2119 CE2 PHE 270 78. .815 22. .452 33, .010 1. .00 42. .41 1SG2120
ATOM 2120 CZ PHE 270 78. .676 21. .362 33. .834 1. .00 42. .41 1SG2121
ATOM 2121 C PHE 270 83 .383 22 , .586 34. .847 1. .00 42, .41 1SG2122
ATOM 2122 O PHE 270 82 .754 22. .838 35, .874 1, .00 42, .41 1SG2123
ATOM 2123 N THR 271 84. .266 21. .572 34, .779 1. .00 41. .52 1SG2124
ATOM 2124 CA THR 271 84. .439 20. .606 35. .830 1. .00 41. .52 1SG2125
ATOM 2125 CB THR 271 85 .459 19, .553 35. .508 1. .00 41, .52 1SG2126
ATOM 2126 OGl THR 271 85 .425 18, .527 36, .490 1. .00 41, .52 1SG2127
ATOM 2127 CG2 THR 271 86. .851 20, .206 35. .475 1. .00 41. .52 1SG2128
ATOM 2128 C THR 271 84. .900 21. .290 37. .073 1. .00 41. .52 1SG2129
ATOM 2129 O THR 271 84 .614 20. .841 38. .182 1. .00 41, .52 1SG2130
ATOM 2130 N ALA 272 85 .660 22. .383 36. .914 1, .00 40, .43 1SG2131
ATOM 2131 CA ALA 272 86 .183 23. .125 38 .024 1, .00 40, .43 1SG2132
ATOM 2132 CB ALA 272 87. .041 24. .327 37, .593 1. .00 40, .43 1SG2133
ATOM 2133 C ALA 272 85 .031 23. .646 38 .830 1. .00 40, .43 1SG2134
ATOM 2134 O ALA 272 85 .127 23. .742 40 .051 1. .00 40, .43 1SG2135
ATOM 2135 N GLY 273 83 .908 24. .006 38, .176 1. .00 38, .33 1SG2136
ATOM 2136 CA GLY 273 82. .778 24. .518 38, .902 1. .00 38, .33 1SG2137
ATOM 2137 C GLY 273 82 .843 26. .011 38 .879 1 .00 38 .33 1SG2138
ATOM 2138 O GLY 273 82 .135 26, .689 39 .621 1. .00 38, .33 1SG2139
ATOM 2139 N VAL 274 83 .748 26, .544 38, .041 1. .00 37, .51 1SG2140
ATOM 2140 CA VAL 274 83, .973 27. .950 37, .873 1. .00 37, .51 1SG2141
ATOM 2141 CB VAL 274 85 .236 28. .245 37 .119 1 .00 37 .51 1SG2142
ATOM 2142 CGI VAL 274 85 .346 29. .766 36 .929 1. .00 37 .51 1SG2143
ATOM 2143 CG2 VAL 274 86 .420 27, .629 37 .882 1, .00 37, .51 1SG2144
ATOM 2144 C VAL 274 82 .851 28, .616 37, .136 1. .00 37, .51 1SG2145
ATOM 2145 O VAL 274 82 .510 29, .755 37, .448 1. .00 37, .51 1SG2146
ATOM 2146 N PHE 275 82 .257 27, .946 36 .124 1, .00 37 .97 1SG2147
ATOM 2147 CA PHE 275 81 .276 28. .625 35 .322 1, .00 37, .97 1SG2148
ATOM 2148 CB PHE 275 80 .986 27. .906 33, .992 1, .00 37, .97 1SG2149
ATOM 2149 CG PHE 275 80, .077 28. .769 33, .185 1, .00 37. .97 1SG2150
ATOM 2150 CDl PHE 275 80 .598 29. .744 32 .366 1 .00 37. .97 1SG2151
ATOM 2151 CD2 PHE 275 78 .711 28, .615 33 .247 1, .00 37. .97 1SG2152
ATOM 2152 CE1 PHE 275 79, .773 30. .550 31, .618 1, .00 37, .97 1SG2153
ATOM 2153 CE2 PHE 275 77, .881 29. .417 32, .501 1, .00 37, .97 1SG2154
ATOM 2154 CZ PHE 275 78 .411 30. .386 31 .684 1, .00 37, .97 1SG2155
ATOM 2155 C PHE 275 79 .994 28. .736 36 .086 1, .00 37, .97 1SG2156
ATOM 2156 O PHE 275 79, .051 27. .968 35, .889 1, .00 37, .97 1SG2157
ATOM 2157 N ASN 276 79, .930 29. .747 36, .972 1, .00 38. .64 1SG2158
ATOM 2158 CA ASN 276 78 .751 30. .006 37 .740 1, .00 38. .64 1SG2159
ATOM 2159 CB ASN 276 78, .757 29. .339 39 .125 1, .00 38, .64 1SG2160
ATOM 2160 CG ASN 276 78, .647 27. .837 38 .920 1. .00 38. .64 1SG2161
ATOM 2161 ODl ASN 276 77, .858 27. .365 38, .103 1, .00 38. .64 1SG2162
ATOM 2162 ND2 ASN 276 79 .466 27. .060 39 .678 1, .00 38. .64 1SG2163
ATOM 2163 C ASN 276 78, .726 31. .482 37 .963 1, .00 38. .64 1SG2164
ATOM 2164 O ASN 276 79, .775 32. .123 38, .005 1. .00 38. .64 1SG2165
ATOM 2165 N VAL 277 77, .523 32. .073 38, .089 1. .00 40. .91 1SG2166
ATOM 2166 CA VAL 277 77, .481 33. .487 38 .315 1. .00 40, .91 1SG2167
ATOM 2167 CB VAL 277 77, .415 34. .284 37 .046 1, .00 40, .91 1SG2168
ATOM 2168 CGI VAL 277 77, .261 35. .771 37, .407 1. .00 40. .91 1SG2169
ATOM 2169 CG2 VAL 277 78. .665 33. .970 36, .205 1. ,00 40. .91 1SG2170
ATOM 2170 C VAL 111 76. .244 33. .807 39 .089 1. .00 40. .91 1SG2171 ATOM 2171 O VAL 277 75..206 33..171 38..913 1..00 40.,91 1SG2172
ATOM 2172 N THR 278 76. .331 34. .823 39. .970 1. .00 43. .94 1SG2173
ATOM 2173 CA THR 278 75. .190 35. .235 40. .732 1. .00 43. .94 1SG2174
ATOM 2174 CB THR 278 75. .430 35. .356 42. .206 1. .00 43. .94 1SG2175
ATOM 2175 OGl THR 278 76, .500 36. .254 42, .457 1. .00 43. .94 1SG2176
ATOM 2176 CG2 THR 278 75, .731 33. .971 42, .784 1. .00 43. .94 1SG2177
ATOM 2177 C THR 278 74. .825 36. .597 40, .264 1. .00 43. .94 1SG2178
ATOM 2178 O THR 278 75. .676 37. .471 40. .105 1. .00 43. .94 1SG2179
ATOM 2179 N LEU 279 73. .524 36. .804 40, .023 1, .00 45. .30 1SG2180
ATOM 2180 CA LEU 279 73. .072 38. .073 39, .554 1. .00 45. .30 1SG2181
ATOM 2181 CB LEU 279 72. .175 37. .907 38. .318 1. .00 45. .30 1SG2182
ATOM 2182 CG LEU 279 72, .919 37. .192 37. .169 1. .00 45. .30 1SG2183
ATOM 2183 CD2 LEU 279 74, .137 37. .998 36. .696 1. .00 45. .30 1SG2184
ATOM 2184 CDl LEU 279 71. .988 36. .849 36. .007 1. .00 45. .30 1SG2185
ATOM 2185 C LEU 279 72, .278 38. .668 40. .668 1, .00 45, .30 1SG2186
ATOM 2186 O LEU 279 71, .395 38. .018 41, .224 1, .00 45. .30 1SG2187
ATOM 2187 N SER 280 72. .595 39. .927 41, .029 1, .00 44. .67 1SG2188
ATOM 2188 CA SER 280 71, .916 40. .594 42. .099 1, .00 44, .67 1SG2189
ATOM 2189 CB SER 280 72 .859 41, .144 43 .184 1 .00 44 .67 1SG2190
ATOM 2190 OG SER 280 72, .108 41, .788 44, .202 1, .00 44, .67 1SG2191
ATOM 2191 C SER 280 71, .192 41. .764 41, .507 1, .00 44, .67 1SG2192
ATOM 2192 O SER 280 71 .492 42. .212 40 .402 1 .00 44 .67 1SG2193
ATOM 2193 N THR 281 70 .199 42, .275 42, .258 1, .00 44, .18 1SG2194
ATOM 2194 CA THR 281 69, .351 43. .352 41, .834 1, .00 44, .18 1SG2195
ATOM 2195 CB THR 281 68, .294 43 , .685 42. .844 1, .00 44, .18 1SG2196
ATOM 2196 OGl THR 281 67 .380 44, .628 42 .305 1 .00 44, .18 1SG2197
ATOM 2197 CG2 THR 281 68 .974 44, .258 44, .099 1, .00 44, .18 1SG2198
ATOM 2198 C THR 281 70 .179 44 , .581 41. .635 1, .00 44, .18 1SG2199
ATOM 2199 O THR 281 69 .890 45, .404 40 .770 1 .00 44 .18 1SG2200
ATOM 2200 N GLU 282 71 .235 44, .733 42, .448 1 .00 42, .96 1SG2201
ATOM 2201 CA GLU 282 72 .076 45, .894 42, .429 1, .00 42, .96 1SG2202
ATOM 2202 CB GLU 282 73 .203 45. .798 43 , .473 1. .00 42, .96 1SG2203
ATOM 2203 CG GLU 282 74 .065 47. .055 43 .587 1 .00 42, .96 1SG2204
ATOM 2204 CD GLU 282 75 .107 47. .040 42, .477 1, .00 42, .96 1SG2205
ATOM 2205 OEl GLU 282 75 .570 45, .926 42, .114 1, .00 42, .96 1SG2206
ATOM 2206 OE2 GLU 282 75 .453 48 .143 41 .977 1 .00 42 .96 1SG2207
ATOM 2207 C GLU 282 72 .709 46, .045 41 .081 1 .00 42, .96 1SG2208
ATOM 2208 O GLU 282 72 .947 47, .161 40, .622 1, .00 42, .96 1SG2209
ATOM 2209 N GLU 283 73 .003 44 , .920 40, .411 1, .00 43, .21 1SG2210
ATOM 2210 CA GLU 283 73 .715 44. .925 39 .164 1 .00 43. .21 1SG2211
ATOM 2211 CB GLU 283 73 .963 43, .509 38, .615 1, .00 43, .21 1SG2212
ATOM 2212 CG GLU 283 74 .919 42, .675 39, .469 1, .00 43, .21 1SG2213
ATOM 2213 CD GLU 283 75 .066 41, .312 38 .807 1, .00 43, .21 1SG2214
ATOM 2214 OEl GLU 283 74 .432 41, .102 37, .739 1, .00 43, .21 1SG2215
ATOM 2215 OE2 GLU 283 75 .817 40, .464 39, .359 1, .00 43, .21 1SG2216
ATOM 2216 C GLU 283 72, .987 45, .685 38, .089 1. .00 43. .21 1SG2217
ATOM 2217 O GLU 283 73 .633 46, .305 37 .246 1, .00 43. .21 1SG2218
ATOM 2218 N ILE 284 71 .639 45, .656 38, .051 1, .00 46. .66 1SG2219
ATOM 2219 CA ILE 284 70, .984 46. .292 36, .935 1, .00 46. .66 1SG2220
ATOM 2220 CB ILE 284 69 .963 45, .410 36 .278 1, .00 46. .66 1SG2221
ATOM 2221 CG2 ILE 284 70 .690 44, .186 35, .698 1, .00 46, .66 1SG2222
ATOM 2222 CGI ILE 284 68 .846 45. .057 37, .273 1, .00 46. .66 1SG2223
ATOM 2223 CDl ILE 284 67, .647 44. .368 36. .624 1. .00 46. .66 1SG2224
ATOM 2224 C ILE 284 70 .283 47, .551 37. .351 1. .00 46, .66 1SG2225
ATOM 2225 O ILE 284 69 .512 47, .572 38. .308 1. .00 46. .66 1SG2226
ATOM 2226 N SER 285 70 .592 48. .657 36. .641 1. .00 48. .72 1SG2227
ATOM 2227 CA SER 285 70 .026 49. .960 36, .867 1. .00 48. .72 1SG2228 ATOM 2228 CB SER 285 70..927 51..088 36..336 1.,00 48..72 1SG2229
ATOM 2229 OG SER 285 72. .162 51. .097 37. .037 1. .00 48. ,72 1SG2230
ATOM 2230 C SER 285 68. .672 50. .147 36. .222 1. ,00 48. .72 1SG2231
ATOM 2231 O SER 285 67. .863 50. .937' 36. .706 1. ,00 48. .72 1SG2232
ATOM 2232 N ASN 286 68. .389 49. .432 35. .113 1. .00 51. .15 1SG2233
ATOM 2233 CA ASN 286 67. .231 49. .663 34. .279 1. .00 51. .15 1SG2234
ATOM 2234 CB ASN 286 67. .366 48. .962 32. .909 1. .00 51. .15 1SG2235
ATOM 2235 CG ASN 286 66. .484 49. .651 31. .873 1. .00 51. .15 1SG2236
ATOM 2236 ODl ASN 286 65. .374 49, .212 31. .579 1. .00 51. .15 1SG2237
ATOM 2237 ND2 ASN 286 66. .996 50, .775 31. .303 1. .00 51. .15 1SG2238
ATOM 2238 C ASN 286 65. .946 49, .226 34. .928 1. .00 51. .15 1SG2239
ATOM 2239 O ASN 286 65. .907 48. .853 36 , .099 1. .00 51. .15 1SG2240
ATOM 2240 N HIS 287 64. .846 49. .316 34. .142 1. ,00 53. .09 1SG2241
ATOM 2241 CA HIS 287 63. .483 49. .072 34. .532 1. .00 53. .09 1SG2242
ATOM 2242 NDl HIS 287 60. .317 50. .109 34. .423 1. .00 53. .09 1SG2243
ATOM 2243 CG HIS 287 61. .060 49. .119 33. .820 1. .00 53. .09 1SG2244
ATOM 2244 CB HIS 287 62. .485 49, .286 33. .383 1. .00 53. .09 1SG2245
ATOM 2245 NE2 HIS 287 58. .997 48, .326 34. .275 1. .00 53. .09 1SG2246
ATOM 2246 CD2 HIS 287 60. .238 48, .036 33, .737 1. .00 53. .09 1SG2247
ATOM 2247 CE1 HIS 287 59. .092 49, .581 34 .674 1, .00 53, .09 1SG2248
ATOM 2248 C HIS 287 63. .288 47, .679 35 .028 1, .00 53, .09 1SG2249
ATOM 2249 O HIS 287 62, .647 47, .490 36 .061 1. .00 53, .09 1SG2250
ATOM 2250 N PHE 288 63. .814 46 .658 34 .323 1, .00 53, .90 1SG2251
ATOM 2251 CA PHE 288 63, .612 45 .343 34 .860 1. .00 53 .90 1SG2252
ATOM 2252 CB PHE 288 64, .216 44 .183 34 .040 1. .00 53 .90 1SG2253
ATOM 2253 CG PHE 288 63, .398 43 .943 32 .820 1, .00 53 .90 1SG2254
ATOM 2254 CDl PHE 288 62. .308 43, .105 32 .866 1. .00 53, .90 1SG2255
ATOM 2255 CD2 PHE 288 63. .726 44, .549 31, .630 1. .00 53, .90 1SG2256
ATOM 2256 CE1 PHE 288 61, .554 42, .882 31, .739 1. .00 53, .90 1SG2257
ATOM 2257 CE2 PHE 288 62, .975 44, .330 30 .500 1. .00 53, .90 1SG2258
ATOM 2258 CZ PHE 288 61, .886 43, .495 30 .554 1. .00 53, .90 1SG2259
ATOM 2259 C PHE 288 64, .318 45, .324 36 .168 1. .00 53, .90 1SG2260
ATOM 2260 O PHE 288 65, .392 45 .902 36 .317 1. .00 53, .90 1SG2261
ATOM 2261 N VAL 289 63. .701 44 .687 37 .174 1. .00 54, .90 1SG2262
ATOM 2262 CA VAL 289 64. .351 44 .612 38 .442 1, .00 54, .90 1SG2263
ATOM 2263 CB VAL 289 63. .851 45 .625 39 .431 1. .00 54, .90 1SG2264
ATOM 2264 CGI VAL 289 62. .318 45 .568 39 .472 1. .00 54, .90 1SG2265
ATOM 2265 CG2 VAL 289 64. .531 45 .359 40 .784 1, .00 54, .90 1SG2266
ATOM 2266 C VAL 289 64, .145 43 .238 38 .971 1. .00 54, .90 1SG2267
ATOM 2267 O VAL 289 63, .093 42 .634 38 .764 1. .00 54, .90 1SG2268
ATOM 2268 N GLN 290 65, .172 42 .697 39 .655 1. .00 59, .06 1SG2269
ATOM 2269 CA GLN 290 65, .017 41, .381 40 .183 1. .00 59. .06 1SG2270
ATOM 2270 CB GLN 290 66, .336 40, .584 40, .240 1. .00 59. .06 1SG2271
ATOM 2271 CG GLN 290 67. .432 41, .175 41. .126 1. .00 59. .06 1SG2272
ATOM 2272 CD GLN 290 68. .668 40, .303 40. .941 1. .00 59. .06 1SG2273
ATOM 2273 OEl GLN 290 69, .282 39, .840 41 .900 1. .00 59. .06 1SG2274
ATOM 2274 NE2 GLN 290 69, .053 40, .077 39 .656 1. .00 59. .06 1SG2275
ATOM 2275 C GLN 290 64, .428 41, .516 41 .546 1. .00 59. .06 1SG2276
ATOM 2276 O GLN 290 65, .121 41, .522 42 .561 1. .00 59. .06 1SG2277
ATOM 2277 N ASN 291 63, .091 41, .634 41 .586 1. .00 65. .07 1SG2278
ATOM 2278 CA ASN 291 62, .380 41, .760 42 .821 1. .00 65. .07 1SG2279
ATOM 2279 CB ASN 291 62, .148 43, .216 43 .269 1. .00 65. .07 1SG2280
ATOM 2280 CG ASN 291 61, .350 43, .931 42 .196 1. .00 65. .07 1SG2281
ATOM 2281 ODl ASN 291 61, .375 43, .532 41 .033 1. .00 65. .07 1SG2282
ATOM 2282 ND2 ASN 291 60, .627 45, .015 42 .587 1. .00 65, .07 1SG2283
ATOM 2283 C ASN 291 61, .061 41, .074 42 .649 1. .00 65, .07 1SG2284
ATOM 2284 O ASN 291 60. .605 40, .858 41, .526 1. .00 65. .07 1SG2285 ATOM 2285 N SER 292 60..435 40..681 43..779 1..00 71..86 1SG2286
ATOM 2286 CA SER 292 59, .172 39. .997 43. ,764 1. .00 71. .86 1SG2287
ATOM 2287 CB SER 292 58, .716 39, .564 45. .169 1. .00 71. .86 1SG2288
ATOM 2288 OG SER 292 58. .525 40, .703 45. .995 1. .00 71. .86 1SG2289
ATOM 2289 C SER 292 58. .149 40, .929 43. .212 1, .00 71. .86 1SG2290
ATOM 2290 O SER 292 57. .315 40 .546 42. .393 1. .00 71. .86 1SG2291
ATOM 2291 N GLN 293 58, .214 42 .214 43. .613 1. .00 77. .73 1SG2292
ATOM 2292 CA GLN 293 57, .339 43, .178 43. .011 1. .00 77. .73 1SG2293
ATOM 2293 CB GLN 293 57. .415 44, .569 43. .661 1. .00 77. .73 1SG2294
ATOM 2294 CG GLN 293 56. .918 44 .591 45, .108 1. .00 77. .73 1SG2295
ATOM 2295 CD GLN 293 57. .046 46, .014 45. .631 1. .00 77. .73 1SG2296
ATOM 2296 OEl GLN 293 56. .687 46, .304 46. .771 1. .00 77. .73 1SG2297
ATOM 2297 NE2 GLN 293 57. .570 46, .932 44. .774 1. .00 77. .73 1SG2298
ATOM 2298 C GLN 293 57, .920 43 .274 41. .646 1. .00 77. .73 1SG2299
ATOM 2299 O GLN 293 58, .993 42, .772 41. .416 1. .00 77, .73 1SG2300
ATOM 2300 N GLY 294 57. .282 43. .803 40. .621 1. .00 76. .23 1SG2301
ATOM 2301 CA GLY 294 58. .052 43. .796 39. .405 1. .00 76. .23 1SG2302
ATOM 2302 C GLY 294 57. .784 42 .485 38. .733 1. .00 76, .23 1SG2303
ATOM 2303 O GLY 294 57. .141 42 .431 37. .692 1. .00 76, .23 1SG2304
ATOM 2304 N LEU 295 58. .238 41. .379 39. .357 1, .00 70. .78 1SG2305
ATOM 2305 CA LEU 295 57. .981 40 .050 38. .899 1 .00 70 .78 1SG2306
ATOM 2306 CB LEU 295 58, .703 38 .940 39, .679 1 .00 70 .78 1SG2307
ATOM 2307 CG LEU 295 58, .374 37 .540 39. .123 1. .00 70. .78 1SG2308
ATOM 2308 CD2 LEU 295 58. .917 36. .424 40. .029 1, .00 70. .78 1SG2309
ATOM 2309 CDl LEU 295 58. .847 37 .398 37, .668 1 .00 70 .78 1SG2310
ATOM 2310 C LEU 295 56, .527 39 .888 39, .126 1 .00 70, .78 1SG2311
ATOM 2311 O LEU 295 55, .868 39. .033 38, .541 1, .00 70. .78 1SG2312
ATOM 2312 N GLY 296 56, .001 40. .722 40. .038 1. .00 64, .64 1SG2313
ATOM 2313 CA GLY 296 54, .620 40 .643 40. .401 1 .00 64 .64 1SG2314
ATOM 2314 C GLY 296 53, .745 40 .834 39. .204 1 .00 64. .64 1SG2315
ATOM 2315 O GLY 296 52, .669 40, .240 39, .129 1. .00 64, .64 1SG2316
ATOM 2316 N ASN 297 54, .133 41, .693 38. .243 1, .00 62, .96 1SG2317
ATOM 2317 CA ASN 297 53, .191 41 .860 37. .168 1 .00 62 .96 1SG2318
ATOM 2318 CB ASN 297 53. .563 42 .948 36, .136 1, .00 62, .96 1SG2319
ATOM 2319 CG ASN 297 54. .702 42, .493 35. .234 1, .00 62, .96 1SG2320
ATOM 2320 ODl ASN 297 55. .708 41 .936 35. .667 1, .00 62, .96 1SG2321
ATOM 2321 ND2 ASN 297 54, .530 42 .735 33 , .906 1, .00 62, .96 1SG2322
ATOM 2322 C ASN 297 53, .029 40 .556 36 , .436 1, .00 62, .96 1SG2323
ATOM 2323 O ASN 297 51, .917 40, .164 36. .079 1, .00 62, .96 1SG2324
ATOM 2324 N VAL 298 54, .162 39 .882 36. .161 1 .00 68 .09 1SG2325
ATOM 2325 CA VAL 298 54, .239 38 .634 35. .448 1 .00 68, .09 1SG2326
ATOM 2326 CB VAL 298 55, .654 38 .341 35, .042 1, .00 68, .09 1SG2327
ATOM 2327 CGI VAL 298 55. .747 36, .887 34. .554 1, .00 68. .09 1SG2328
ATOM 2328 CG2 VAL 298 56. .089 39 .388 34. .003 1 .00 68. .09 1SG2329
ATOM 2329 C VAL 298 53, .788 37, .434 36, .225 1, .00 68. .09 1SG2330
ATOM 2330 O VAL 298 52, .998 36, .633 35. .724 1, .00 68. .09 1SG2331
ATOM 2331 N LEU 299 54, .299 37, .244 37. .460 1, .00 75. .18 1SG2332
ATOM 2332 CA LEU 299 53, .949 36 .000 38, .067 1, .00 75, .18 1SG2333
ATOM 2333 CB LEU 299 55, .024 34, .942 37, .796 1, .00 75, .18 1SG2334
ATOM 2334 CG LEU 299 54. .650 33, .527 38. .243 1. .00 75. .18 1SG2335
ATOM 2335 CD2 LEU 299 55. .870 32, .606 38, .134 1, .00 75. .18 1SG2336
ATOM 2336 CDl LEU 299 53. .437 32, .987 37. .467 1, .00 75. .18 1SG2337
ATOM 2337 C LEU 299 53. .788 36, .136 39. .548 1, .00 75. .18 1SG2338
ATOM 2338 O LEU 299 54, .753 35, .994 40. .298 1, .00 75. .18 1SG2339
ATOM 2339 N SER 300 52, .547 36, .362 40. .026 1, .00 77. .80 1SG2340
ATOM 2340 CA SER 300 52. .395 36. .459 41. .448 1, .00 77. .80 1SG2341
ATOM 2341 CB SER 300 52. .103 37. .879 41. .945 1, .00 77. .80 1SG2342 ATOM 2342 OG SER 300 53..262 38..673 41..788 1..00 77..80 1SG2343
ATOM 2343 C SER 300 51. .250 35. .632 41. .927 1. ,00 77. .80 1SG2344
ATOM 2344 O SER 300 50. .089 35. ,989 41. ,724 1. .00 77. .80 1SG2345
ATOM 2345 N ARG 301 51. .541 34. ,476 42. .561 1. 00 72. 95 1SG2346
ATOM 2346 CA ARG 301 52. .862 33. .922 42. .619 1. .00 72. .95 1SG2347
ATOM 2347 CB ARG 301 53, .497 33. ,734 41. .232 1. .00 72. .95 1SG2348
ATOM 2348 CG ARG 301 52, .640 32. ,870 40. .304 1. ,00 72. ,95 1SG2349
ATOM 2349 CD ARG 301 51. .352 33. ,554 39. .841 1. ,00 72. ,95 1SG2350
ATOM 2350 NE ARG 301 50. .622 32. .608 38, .952 1. ,00 72. ,95 1SG2351
ATOM 2351 CZ ARG 301 49. .363 32. .915 38, .522 1. .00 72. .95 1SG2352
ATOM 2352 NHl ARG 301 48. .769 34. .076 38, .926 1. .00 72. .95 1SG2353
ATOM 2353 NH2 ARG 301 48, .700 32. .064 37, .686 1. .00 72. .95 1SG2354
ATOM 2354 C ARG 301 53, .816 34. .666 43. .508 1. .00 72. .95 1SG2355
ATOM 2355 O ARG 301 53 .549 34. .910 44 .683 1. .00 72. .95 1SG2356
ATOM 2356 N ILE 302 54 .981 35, .041 42, .933 1. .00 61. .09 1SG2357
ATOM 2357 CA ILE 302 56, .101 35, ,576 43. .661 1. .00 61. .09 1SG2358
ATOM 2358 CB ILE 302 57. .228 36, .033 42. .780 1. .00 61. .09 1SG2359
ATOM 2359 CG2 ILE 302 56, .738 37, .214 41, .925 1. .00 61. .09 1SG2360
ATOM 2360 CGI ILE 302 58 .461 36, .349 43 .646 1, .00 61. .09 1SG2361
ATOM 2361 CDl ILE 302 59 .754 36, .527 42 .852 1. .00 61, .09 1SG2362
ATOM 2362 C ILE 302 55, .709 36, .732 44 .524 1. .00 61. .09 1SG2363
ATOM 2363 O ILE 302 56, .148 36, ,809 45 .670 1. .00 61. .09 1SG2364
ATOM 2364 N ALA 303 54 .903 37 .681 44 .027 1. .00 48. .12 1SG2365
ATOM 2365 CA ALA 303 54 .552 38, .747 44 .919 1. .00 48. .12 1SG2366
ATOM 2366 CB ALA 303 53, .731 39, .865 44 .256 1, .00 48. .12 1SG2367
ATOM 2367 C ALA 303 53, .725 38, .192 46 .036 1, .00 48, .12 1SG2368
ATOM 2368 O ALA 303 53. .939 38, .529 47, .198 1. .00 48, .12 1SG2369
ATOM 2369 N GLU 304 52 .751 37 .321 45 .706 1, .00 40 .73 1SG2370
ATOM 2370 CA GLU 304 51 .836 36, .825 46 .699 1, .00 40, .73 1SG2371
ATOM 2371 CB GLU 304 50 .716 35, .971 46 .082 1, .00 40, .73 1SG2372
ATOM 2372 CG GLU 304 49. .778 36, ,762 45, .167 1, .00 40, .73 1SG2373
ATOM 2373 CD GLU 304 48 .728 35, .799 44 .632 1, .00 40 .73 1SG2374
ATOM 2374 OEl GLU 304 48 .785 34. .596 45 .003 1, .00 40 .73 1SG2375
ATOM 2375 OE2 GLU 304 47 .853 36. .253 43 .847 1, .00 40, .73 1SG2376
ATOM 2376 C GLU 304 52 .516 35, .968 47, .726 1, .00 40, .73 1SG2377
ATOM 2377 O GLU 304 52. .418 36, ,230 48, .923 1. .00 40, .73 1SG2378
ATOM 2378 N ILE 305 53 .228 34 .914 47 .282 1, .00 38 .48 1SG2379
ATOM 2379 CA ILE 305 53 .841 34, .008 48 .211 1, .00 38, .48 1SG2380
ATOM 2380 CB ILE 305 54 .439 32, .808 47 .538 1. .00 38, .48 1SG2381
ATOM 2381 CG2 ILE 305 55. .212 32, .007 48, .599 1. .00 38, .48 1SG2382
ATOM 2382 CGI ILE 305 53 .347 31 .993 46 .826 1. .00 38 .48 1SG2383
ATOM 2383 CDl ILE 305 52 .269 31 .465 47 .772 1, .00 38, .48 1SG2384
ATOM 2384 C ILE 305 54 .941 34, .713 48 .915 1, .00 38, .48 1SG2385
ATOM 2385 0 ILE 305 55, .042 34, .675 50, .141 1. .00 38, .48 1SG2386
ATOM 2386 N TYR 306 55, .800 35, .397 48, .144 1. .00 42. .11 1SG2387
ATOM 2387 CA TYR 306 56 .876 36 .071 48 .782 1. .00 42, .11 1SG2388
ATOM 2388 CB TYR 306 58 .209 35 .892 48 .039 1. .00 42, .11 1SG2389
ATOM 2389 CG TYR 306 58 .410 34 .422 47, .895 1. .00 42, .11 1SG2390
ATOM 2390 CDl TYR 306 58 .911 33. .662 48, .927 1. .00 42. .11 1SG2391
ATOM 2391 CD2 TYR 306 58 .086 33 .804 46 .710 1, .00 42. .11 1SG2392
ATOM 2392 CE1 TYR 306 59 .084 32 .305 48 .774 1, .00 42. .11 1SG2393
ATOM 2393 CE2 TYR 306 58 .256 32. .451 46 .551 1. .00 42. .11 1SG2394
ATOM 2394 CZ TYR 306 58, .756 31, .698 47, .585 1. .00 42. .11 1SG2395
ATOM 2395 OH TYR 306 58 .928 30, ,308 47, .419 1. .00 42. .11 1SG2396
ATOM 2396 C TYR 306 56 .523 37, .510 48 .720 1, .00 42. .11 1SG2397
ATOM 2397 O TYR 306 56 .956 38 .227 47. .817 1. .00 42. .11 1SG2398
ATOM 2398 N ILE 307 55, .743 37, .976 49. .716 1. .00 48. .40 1SG2399 ATOM 2399 CA ILE 307 55.,381 39.,360 49..743 1.,00 48..40 1SG2400
ATOM 2400 CB ILE 307 54. ,093 39. .610 50. .477 1. ,00 48. ,40 1SG2401
ATOM 2401 CG2 ILE 307 52. .957 38. .893 49. .731 1. ,00 48. ,40 1SG2402
ATOM 2402 CGI ILE 307 54. .223 39. .182 51. .949 1. .00 48. .40 1SG2403
ATOM 2403 CDl ILE 307 53. .076 39. .672 52. .832 1. .00 48. .40 1SG2404
ATOM 2404 C ILE 307 56. .457 39. .996 50. .540 1. .00 48. .40 1SG2405
ATOM 2405 O ILE 307 56. .252 40. .918 51. .323 1. .00 48. .40 1SG2406
ATOM 2406 N LEU 308 57. .677 39. .522 50. .297 1. .00 53. .13 1SG2407
ATOM 2407 CA LEU 308 58. .824 40. .037 50. .941 1. .00 53. .13 1SG2408
ATOM 2408 CB LEU 308 60. .090 39. .265 50. .545 1. .00 53. .13 1SG2409
ATOM 2409 CG LEU 308 60, .148 37. .831 51. .098 1. .00 53. .13 1SG2410
ATOM 2410 CD2 LEU 308 61, .460 37. .146 50, .689 1, .00 53. .13 1SG2411
ATOM 2411 CDl LEU 308 58. .922 37, .011 50, .681 1. .00 53. .13 1SG2412
ATOM 2412 C LEU 308 58, .948 41, .419 50, .431 1, .00 53. .13 1SG2413
ATOM 2413 O LEU 308 59, .472 42, .288 51, .125 1. .00 53, .13 1SG2414
ATOM 2414 N SER 309 58, .468 41, .631 49, .182 1. .00 58. .18 1SG2415
ATOM 2415 CA SER 309 58, .710 42, .859 48, .492 1, .00 58. .18 1SG2416
ATOM 2416 CB SER 309 58, .060 44, .126 49, .100 1, .00 58, .18 1SG2417
ATOM 2417 OG SER 309 58, .746 44, .587 50 .254 1. .00 58, .18 1SG2418
ATOM 2418 C SER 309 60 .191 42, .925 48 .558 1. .00 58 .18 1SG2419
ATOM 2419 O SER 309 60 .803 43 .955 48 .833 1 .00 58 .18 1SG2420
ATOM 2420 N GLN 310 60 .793 41, .740 48 .334 1 .00 59 .50 1SG2421
ATOM 2421 CA GLN 310 62. .204 41, .583 48, .434 1. .00 59. .50 1SG2422
ATOM 2422 CB GLN 310 62, .670 40. .458 49, .376 1. .00 59. .50 1SG2423
ATOM 2423 CG GLN 310 62, .562 40. .828 50, .858 1, .00 59, .50 1SG2424
ATOM 2424 CD GLN 310 63 , .627 41, .870 51, .167 1. .00 59, .50 1SG2425
ATOM 2425 OEl GLN 310 63, .325 42, .960 51, .652 1, .00 59, .50 1SG2426
ATOM 2426 NE2 GLN 310 64, .914 41, .524 50. .894 1, .00 59, .50 1SG2427
ATOM 2427 C GLN 310 62. .752 41, .318 47. .089 1. .00 59, .50 1SG2428
ATOM 2428 O GLN 310 62. .052 41, .159 46, .089 1. .00 59. .50 1SG2429
ATOM 2429 N PRO 311 64, .047 41, .349 47 .101 1, .00 57, .27 1SG2430
ATOM 2430 CA PRO 311 64, .783 41, .143 45, .895 1, .00 57, .27 1SG2431
ATOM 2431 CD PRO 311 64 .757 42, .213 48 .027 1, .00 57, .27 1SG2432
ATOM 2432 CB PRO 311 66, .158 41, .782 46 .113 1, .00 57, .27 1SG2433
ATOM 2433 CG PRO 311 66 .229 42, .056 47 .625 1, .00 57 .27 1SG2434
ATOM 2434 C PRO 311 64, .846 39, .706 45 .538 1, .00 57, .27 1SG2435
ATOM 2435 O PRO 311 64 .648 38, .857 46 .406 1, .00 57, .27 1SG2436
ATOM 2436 N PHE 312 65 .098 39 .406 44 .254 1, .00 53 .18 1SG2437
ATOM 2437 CA PHE 312 65 .265 38 .030 43 .940 1. .00 53, .18 1SG2438
ATOM 2438 CB PHE 312 64 .201 37, .374 43 .029 1, .00 53, .18 1SG2439
ATOM 2439 CG PHE 312 64 .197 37, .887 41 .631 1, .00 53 .18 1SG2440
ATOM 2440 CDl PHE 312 65 .193 37 .533 40 .750 1, .00 53 .18 1SG2441
ATOM 2441 CD2 PHE 312 63 .163 38 .678 41 .185 1, .00 53, .18 1SG2442
ATOM 2442 CE1 PHE 312 65 .176 37 .991 39 .454 1, .00 53 .18 1SG2443
ATOM 2443 CE2 PHE 312 63 .139 39 .137 39 .890 1, .00 53, .18 1SG2444
ATOM 2444 CZ PHE 312 64. .150 38, .797 39, .023 1. .00 53. .18 1SG2445
ATOM 2445 C PHE 312 66. .621 37, .891 43, .353 1. .00 53. .18 1SG2446
ATOM 2446 O PHE 312 67. .114 38, .804 42, .693 1. .00 53. .18 1SG2447
ATOM 2447 N MET 313 67, .279 36, .751 43, .634 1. .00 46. .07 1SG2448
ATOM 2448 CA MET 313 68, .606 36, .538 43, .148 1. .00 46. .07 1SG2449
ATOM 2449 CB MET 313 69, .617 36, .157 44, .243 1. .00 46. .07 1SG2450
ATOM 2450 CG MET 313 69, .346 34, .792 44, .878 1. .00 46. .07 1SG2451
ATOM 2451 SD MET 313 70, .599 34. .258 46, .083 1. .00 46. .07 1SG2452
ATOM 2452 CE MET 313 70, .172 35. .503 47, .334 1. .00 46. .07 1SG2453
ATOM 2453 C MET 313 68, .548 35. .403 42, .183 1. .00 46. .07 1SG2454
ATOM 2454 O MET 313 67, .804 34. .444 42, .386 1. .00 46. .07 1SG2455
ATOM 2455 N VAL 314 69, .331 35. .495 41. .089 1. .00 40. .32 1SG2456 ATOM 2456 CA VAL 314 69..305 34..449 40..112 1..00 40..32 1SG2457
ATOM 2457 CB VAL 314 68. .941 34. .925 38. .735 1. .00 40. .32 1SG2458
ATOM 2458 CGI VAL 314 70 .049 35. .865 38 .231 1, .00 40, .32 1SG2459
ATOM 2459 CG2 VAL 314 68. .711 33, .697 37 .838 1. .00 40, .32 1SG2460
ATOM 2460 C VAL 314 70. .669 33. .843 40, .023 1. .00 40. .32 1SG2461
ATOM 2461 O VAL 314 71 .681 34, .542 40 .063 1, .00 40. .32 1SG2462
ATOM 2462 N ARG 315 70. .727 32, .502 39 .902 1. .00 35. .78 1SG2463
ATOM 2463 CA ARG 315 72. .000 31. .854 39 .806 1, .00 35, .78 1SG2464
ATOM 2464 CB ARG 315 72 .214 30. .751 40 .858 1. .00 35, .78 1SG2465
ATOM 2465 CG ARG 315 71. .147 29, .655 40 .847 1. .00 35. .78 1SG2466
ATOM 2466 CD ARG 315 71. .389 28. .576 41, .904 1. .00 35. .78 1SG2467
ATOM 2467 NE ARG 315 70 .165 27. .730 41 .984 1. .00 35 .78 1SG2468
ATOM 2468 CZ ARG 315 69 .170 28. .070 42 .856 1, .00 35. .78 1SG2469
ATOM 2469 NHl ARG 315 69. .289 29. .198 43 .615 1. ,00 35. .78 1SG2470
ATOM 2470 NH2 ARG 315 68 .061 27. .285 42 .977 1. .00 35. .78 1SG2471
ATOM 2471 C ARG 315 72 .123 31. .248 38 .447 1. ,00 35. .78 1SG2472
ATOM 2472 O ARG 315 71. .226 30. .551 37 .974 1. ,00 35, .78 1SG2473
ATOM 2473 N ILE 316 73 .262 31. .520 37 .778 1. .00 32 .65 1SG2474
ATOM 2474 CA ILE 316 73 .486 30, .994 36 .465 1. .00 32, .65 1SG2475
ATOM 2475 CB ILE 316 73. .792 32, .056 35 .439 1. .00 32, .65 1SG2476
ATOM 2476 CG2 ILE 316 72 .588 33, .012 35 .388 1. .00 32 .65 1SG2477
ATOM 2477 CGI ILE 316 75 .111 32, .783 35 .748 1 , .00 32, .65 1SG2478
ATOM 2478 CDl ILE 316 75, .611 33, .645 34, .590 1. .00 32, .65 1SG2479
ATOM 2479 C ILE 316 74 .658 30, .062 36 .545 1, .00 32 .65 1SG2480
ATOM 2480 O ILE 316 75 .738 30, .431 37 .004 1. .00 32 .65 1SG2481
ATOM 2481 N MET 317 74, .461 28, .802 36 .108 1. .00 30, .95 1SG2482
ATOM 2482 CA MET 317 75 .519 27, .835 36 .145 1, .00 30 .95 1SG2483
ATOM 2483 CB MET 317 75. .326 26. .763 37 .232 1. .00 30, .95 1SG2484
ATOM 2484 CG MET 317 74. .165 25. .811 36, .935 1. .00 30, .95 1SG2485
ATOM 2485 SD MET 317 73 .892 24. .521 38 .186 1, .00 30 .95 1SG2486
ATOM 2486 CE MET 317 73. .140 25. .630 39 .411 1 , .00 30, .95 1SG2487
ATOM 2487 C MET 317 75. .502 27, .118 34, .834 1. .00 30, .95 1SG2488
ATOM 2488 O MET 317 74 .500 27, .136 34 .121 1. .00 30, .95 1ΞG2489
ATOM 2489 N ALA 318 76. .628 26, .470 34 .477 1. .00 30, .06 1SG2490
ATOM 2490 CA ALA 318 76. .675 25, .752 33, .237 1. .00 30, .06 1SG2491
ATOM 2491 CB ALA 318 78 .078 25, .705 32 .609 1. .00 30, .06 1SG2492
ATOM 2492 C ALA 318 76, .269 24, .346 33 .531 1. .00 30, .06 1SG2493
ATOM 2493 O ALA 318 76, .824 23, .702 34, .420 1. .00 30, .06 1SG2494
ATOM 2494 N THR 319 75, .245 23, .854 32 .806 1. .00 31, .12 1SG2495
ATOM 2495 CA THR 319 74, .768 22. .515 32 .997 1. .00 31. .12 1SG2496
ATOM 2496 CB THR 319 73. .494 22. .249 32, .252 1. .00 31. .12 1SG2497
ATOM 2497 OGl THR 319 73. .707 22. .386 30 .855 1. .00 31. .12 1SG2498
ATOM 2498 CG2 THR 319 72, .430 23, .253 32, .725 1. .00 31. ,12 1SG2499
ATOM 2499 C THR 319 75. .788 21. .532 32. .508 1. .00 31. .12 1SG2500
ATOM 2500 O THR 319 76. .112 20. .566 33, .198 1. .00 31. .12 1SG2501
ATOM 2501 N GLU 320 76. .330 21. .762 31, .293 1. .00 33. .62 1SG2502
ATOM 2502 CA GLU 320 77. .266 20. .836 30, .718 1. .00 33. .62 1SG2503
ATOM 2503 CB GLU 320 76, .649 19, .959 29, .616 1. .00 33. .62 1SG2504
ATOM 2504 CG GLU 320 76, .092 20, .761 28, .440 1. .00 33. .62 1SG2505
ATOM 2505 CD GLU 320 75. .520 19. .776 27. .432 1. .00 33. .62 1SG2506
ATOM 2506 OEl GLU 320 75. .426 18. .568 27. .775 1. .00 33. .62 1SG2507
ATOM 2507 OE2 GLU 320 75. .166 20. .221 26, .308 1. .00 33. .62 1SG2508
ATOM 2508 C GLU 320 78. .379 21. .627 30. .102 1. 00 33. .62 1SG2509
ATOM 2509 O GLU 320 78. .316 22. .853 30, .027 1. .00 33. ,62 1SG2510
ATOM 2510 N PRO 321 79. .418 20. .952 29. .683 1. .00 36. ,32 1SG2511
ATOM 2511 CA PRO 321 80. ,528 21. ,649 29. .092 1. 00 36. ,32 1SG2512
ATOM 2512 CD PRO 321 79. .844 19. .743 30. .370 1. .00 36. .32 1SG2513 ATOM 2513 CB PRO 321 81..670 20..638 29..028 1.,00 36..32 1SG2514
ATOM 2514 CG PRO 321 81. .374 19. .696 30. .211 1. ,00 36. .32 1SG2515
ATOM 2515 C PRO 321 80, .148 22, .263 27, .785 1. .00 36, .32 1SG2516
ATOM 2516 O PRO 321 79, .507 21 .595 • 26, .976 1. .00 36, .32 1SG2517
ATOM 2517 N PRO 322 80. .549 23, .483 27. .551 1. .00 39, .19 1SG2518
ATOM 2518 CA PRO 322 80. .196 24, .156 26. .333 1. .00 39, .19 1SG2519
ATOM 2519 CD PRO 322 80. .839 24 .417 28. .622 1. .00 39, .19 1SG2520
ATOM 2520 CB PRO 322 80. .472 25 .644 26. .568 1. .00 39 .19 1SG2521
ATOM 2521 CG PRO 322 81, .273 25 .692 27 .883 1. .00 39, .19 1SG2522
ATOM 2522 C PRO 322 80, .926 23, .565 25. .177 1. .00 39, .19 1SG2523
ATOM 2523 O PRO 322 82, .071 23 .141 25. .329 1. .00 39, .19 1SG2524
ATOM 2524 N ILE 323 80, .292 23 .537 23, .995 1. .00 40 .70 1SG2525
ATOM 2525 CA ILE 323 80, .952 22 .906 22 .898 1. .00 40 .70 1SG2526
ATOM 2526 CB ILE 323 80, .169 21, .775 22, .312 1. .00 40, .70 1SG2527
ATOM 2527 CG2 ILE 323 80, .923 21, .261 21. .075 1. .00 40, .70 1SG2528
ATOM 2528 CGI ILE 323 79, .922 20 .714 23. .398 1. .00 40 .70 1SG2529
ATOM 2529 CDl ILE 323 81 .199 20 .239 24, .091 1. .00 40 .70 1SG2530
ATOM 2530 C ILE 323 81 .168 23 .914 21 .827 1. .00 40 .70 1SG2531
ATOM 2531 O ILE 323 80, .376 24, .839 21, .662 1. .00 40, .70 1SG2532
ATOM 2532 N ILE 324 82, .293 23 .777 21, .099 1. .00 42 .24 1SG2533
ATOM 2533 CA ILE 324 82, .586 24 .686 20 .033 1. .00 42 .24 1SG2534
ATOM 2534 CB ILE 324 83 .791 25 .544 20 .298 1. .00 42 .24 1SG2535
ATOM 2535 CG2 ILE 324 84. .065 26, .365 19, .025 1. .00 42, .24 1SG2536
ATOM 2536 CGI ILE 324 83. .565 26 .427 21, .539 1. .00 42 .24 1SG2537
ATOM 2537 CDl ILE 324 83. .458 25 .659 22, .855 1. .00 42 .24 1SG2538
ATOM 2538 C ILE 324 82 .875 23 .871 18 .813 1. .00 42 .24 1SG2539
ATOM 2539 O ILE 324 83 .688 22 .949 18 .851 1. .00 42 .24 1SG2540
ATOM 2540 N ASN 325 82. .210 24, .178 17, .683 1. .00 47, .99 1SG2541
ATOM 2541 CA ASN 325 82. .520 23 .434 16, .500 1. .00 47 .99 1SG2542
ATOM 2542 CB ASN 325 81 .377 22 .548 15, .954 1. .00 47 .99 1SG2543
ATOM 2543 CG ASN 325 80 .067 23 .309 15 .938 1. .00 47 .99 1SG2544
ATOM 2544 ODl ASN 325 79, .632 23, .784 16. .985 1. .00 47, .99 1SG2545
ATOM 2545 ND2 ASN 325 79, .409 23 .387 14. .751 1. .00 47, .99 1SG2546
ATOM 2546 C ASN 325 83 .094 24 .346 15, .471 1. .00 47 .99 1SG2547
ATOM 2547 O ASN 325 82 .631 25 .469 15, .270 1, .00 47 .99 1SG2548
ATOM 2548 N LEU 326 84 .178 23 .884 14 .814 1. .00 53 .92 1SG2549
ATOM 2549 CA LEU 326 84, .826 24, .755 13 , .884 1. .00 53 , .92 1SG2550
ATOM 2550 CB LEU 326 86, .327 24 .899 14 , .152 1. .00 53, .92 1SG2551
ATOM 2551 CG LEU 326 86, .896 26 .090 13, .384 1. .00 53, .92 1SG2552
ATOM 2552 CD2 LEU 326 88, .388 26 .289 13, .664 1. .00 53, .92 1SG2553
ATOM 2553 CDl LEU 326 86, .090 27, .341 13, .746 1. ,00 53 , .92 1SG2554
ATOM 2554 C LEU 326 84, .625 24, .232 12 , .498 1. .00 53, .92 1SG2555
ATOM 2555 O LEU 326 84, .884 23 .064 12, .214 1. .00 53 , .92 1SG2556
ATOM 2556 N GLN 327 84, .130 25 .105 11, .597 1. .00 62, .32 1SG2557
ATOM 2557 CA GLN 327 83 .916 24 .729 10, .230 1. .00 62, .32 1SG2558
ATOM 2558 CB GLN 327 82, .453 24, .392 9, .880 1. .00 62. .32 1SG2559
ATOM 2559 CG GLN 327 81, .904 23, .136 10. .563 1. .00 62. .32 1SG2560
ATOM 2560 CD GLN 327 81. .078 23 .534 11, .782 1. .00 62. .32 1SG2561
ATOM 2561 OEl GLN 327 80. .478 22 .674 12, .424 1. .00 62, .32 1SG2562
ATOM 2562 NE2 GLN 327 81, .031 24, .855 12. .103 1. .00 62. .32 1SG2563
ATOM 2563 C GLN 327 84 , .280 25. .909 9. .394 1. ,00 62. .32 1SG2564
ATOM 2564 O GLN 327 84, .256 27, .038 9. .880 1. ,00 62. .32 1SG2565
ATOM 2565 N PRO 328 84, .658 25, .678 8, .161 1. .00 68. .96 1SG2566
ATOM 2566 CA PRO 328 84, .973 26, .764 7, .278 1. .00 68. .96 1SG2567
ATOM 2567 CD PRO 328 84. .245 24. .489 7. .433 1. .00 68. .96 1SG2568
ATOM 2568 CB PRO 328 85. .211 26. .120 5. .916 1. .00 68. .96 1SG2569
ATOM 2569 CG PRO 328 84 , .266 24. .903 5. .950 1. ,00 68. .96 1SG2570 ATOM 2570 C PRO 328 83..739 27..592 7..259 1..00 68..96 1SG2571
ATOM 2571 O PRO 328 82. .678 27. .037 7. .015 1. .00 68. .96 1SG2572
ATOM 2572 N GLY 329 83 .828 28. .906 7. .484 1. .00 68 .59 1SG2573
ATOM 2573 CA GLY 329 82 .633 29, .688 7. .493 1. .00 68 .59 1SG2574
ATOM 2574 C GLY 329 82. .456 30, .240 8. .866 1, .00 68 .59 1SG2575
ATOM 2575 O GLY 329 82. .131 31. .418 9. .003 1. .00 68, .59 1SG2576
ATOM 2576 N ASN 330 82, .668 29. .430 9, .927 1. .00 66 .44 1SG2577
ATOM 2577 CA ASN 330 82, .518 30. .046 11. .211 1, .00 66 .44 1SG2578
ATOM 2578 CB ASN 330 81. .132 30. .683 11. .443 1, .00 66, .44 1SG2579
ATOM 2579 CG ASN 330 80, .070 29. .597 11. .357 1. .00 66, .44 1SG2580
ATOM 2580 ODl ASN 330 79, .967 28. .891 10. .354 1. .00 66, .44 1SG2581
ATOM 2581 ND2 ASN 330 79 .256 29, .457 12. .437 1 .00 66 .44 1SG2582
ATOM 2582 C ASN 330 82 .737 29, .083 12. .332 1. .00 66 .44 1SG2583
ATOM 2583 O ASN 330 82 .773 27, .867 12, .160 1. .00 66 .44 1SG2584
ATOM 2584 N PHE 331 82 .870 29, .671 13, .535 1. .00 59 .72 1SG2585
ATOM 2585 CA PHE 331 83 .118 29. .031 14, .793 1. .00 59 .72 1SG2586
ATOM 2586 CB PHE 331 84, .035 29. .914 15, .664 1, .00 59 .72 1SG2587
ATOM 2587 CG PHE 331 85, .062 30. .583 14 , .798 1, .00 59 .72 1SG2588
ATOM 2588 CDl PHE 331 84, .718 31, .718 14 , .092 1, .00 59 .72 1SG2589
ATOM 2589 CD2 PHE 331 86, .348 30. .114 14 , .675 1, .00 59 .72 1SG2590
ATOM 2590 CE1 PHE 331 85 .620 32. .366 13 .283 1 .00 59 .72 1SG2591
ATOM 2591 CE2 PHE 331 87 .260 30. .757 13 .867 1 .00 59 .72 1SG2592
ATOM 2592 CZ PHE 331 86 .899 31. .884 13, .168 1 .00 59 .72 1SG2593
ATOM 2593 C PHE 331 81 .798 29. .141 15, .500 1 .00 59 .72 1SG2594
ATOM 2594 O PHE 331 81 .252 30, .239 15, .600 1 .00 59 .72 1SG2595
ATOM 2595 N THR 332 81 .235 28. .034 16, .018 1, .00 53 .80 1SG2596
ATOM 2596 CA THR 332 79 .970 28. .174 16, .685 1, .00 53 .80 1SG2597
ATOM 2597 CB THR 332 78 .846 27. .567 15. .898 1, .00 53 .80 1SG2598
ATOM 2598 OGl THR 332 77, .614 27, .704 16. .582 1. .00 53 .80 1SG2599
ATOM 2599 CG2 THR 332 79 .160 26 .101 15 .613 1 .00 53 .80 1SG2600
ATOM 2600 C THR 332 80 .065 27, .548 18 .044 1 .00 53 .80 1SG2601
ATOM 2601 O THR 332 80 .744 26, .540 18. .223 1 .00 53 .80 1SG2602
ATOM 2602 N LEU 333 79 .397 28, .162 19. .050 1 .00 50 .08 1SG2603
ATOM 2603 CA LEU 333 79 .437 27. .661 20, .398 1, .00 50 .08 1SG2604
ATOM 2604 CB LEU 333 80 .074 28, .630 21, .408 1, .00 50 .08 1SG2605
ATOM 2605 CG LEU 333 81 .607 28, .617 21, .315 1, .00 50 .08 1SG2606
ATOM 2606 CD2 LEU 333 82 .248 29. .553 22. .354 1, .00 50, .08 1SG2607
ATOM 2607 CDl LEU 333 82, .078 28. .887 19. .880 1, .00 50, .08 1SG2608
ATOM 2608 C LEU 333 78 .061 27, .322 20, .874 1 .00 50 .08 1SG2609
ATOM 2609 O LEU 333 77 .083 27. .976 20 .518 1 .00 50 .08 1SG2610
ATOM 2610 N ASP 334 77 .961 26, .251 21, .692 1, .00 46 .48 1SG2611
ATOM 2611 CA ASP 334 76 .686 25. .840 22 , .209 1. .00 46 .48 1SG2612
ATOM 2612 CB ASP 334 76, .288 24. .420 21. .762 1, .00 46. .48 1SG2613
ATOM 2613 CG ASP 334 74, .830 24. .154 22. .126 1, .00 46. .48 1SG2614
ATOM 2614 ODl ASP 334 74, .302 24. .825 23. .053 1. .00 46, .48 1SG2615
ATOM 2615 OD2 ASP 334 74. .222 23. .267 21. .471 1. .00 46 , .48 1SG2616
ATOM 2616 C ASP 334 76, .761 25. .837 23. .708 1. .00 46 , .48 1SG2617
ATOM 2617 O ASP 334 77 .285 24. .902 24. .309 1, .00 46, .48 1SG2618
ATOM 2618 N ILE 335 76 .218 26. .879 24, .368 1, .00 43, .95 1SG2619
ATOM 2619 CA ILE 335 76, .294 26. .896 25. .802 1. .00 43, .95 1SG2620
ATOM 2620 CB ILE 335 76, .855 28. .175 26. .359 1. .00 43, .95 1SG2621
ATOM 2621 CG2 ILE 335 76, .704 28. .126 27. .889 1. .00 43, .95 1SG2622
ATOM 2622 CGI ILE 335 78, .307 28. .377 25. .896 1. .00 43. .95 1SG2623
ATOM 2623 CDl ILE 335 78, .445 28. .621 24. .394 1. .00 43. .95 1SG2624
ATOM 2624 C ILE 335 74, .925 26. ,734 26. .387 1. ,00 43. .95 1SG2625
ATOM 2625 O ILE 335 74. .008 27. .490 26. ,066 1. ,00 43. .95 1SG2626
ATOM 2626 N PRO 336 74. .763 25. .678 27. .157 1. .00 40. .28 1SG2627 ATOM 2627 CA PRO 336 73..551 25..496 27..918 1.,00 40,.28 1SG2628
ATOM 2628 CD PRO 336 75. .315 24. .405 26. .723 1. .00 40. .28 1SG2629
ATOM 2629 CB PRO 336 73. ,259 23. .996 27. ,919 1. ,00 40. .28 1SG2630
ATOM 2630 CG PRO 336 74. .613 23, .349 27. .589 1. .00 40. ,28 1SG2631
ATOM 2631 C PRO 336 73. .752 26, .036 29. .301 1. .00 40. .28 1SG2632
ATOM 2632 O PRO 336 74. .876 25, .986 29. .799 1. .00 40. ,28 1SG2633
ATOM 2633 N ALA 337 72. .691 26. .520 29. .971 1. .00 35. .63 1SG2634
ATOM 2634 CA ALA 337 72. .922 26. .955 31. .314 1, .00 35. .63 1SG2635
ATOM 2635 CB ALA 337 73 , .434 28, .397 31. .446 1. .00 35, .63 1SG2636
ATOM 2636 C ALA 337 71. .654 26, .822 32. .082 1. .00 35, .63 1SG2637
ATOM 2637 O ALA 337 70. .562 26. .800 31. .513 1. .00 35. .63 1SG2638
ATOM 2638 N SER 338 71, .786 26. .704 33, .416 1, .00 32. .90 1SG2639
ATOM 2639 CA SER 338 70, .627 26 .594 34. .243 1. .00 32. .90 1SG2640
ATOM 2640 CB SER 338 70, .733 25, .513 35. .333 1. .00 32, .90 1SG2641
ATOM 2641 OG SER 338 70. .778 24, .221 34. .747 1. .00 32. .90 1SG2642
ATOM 2642 C SER 338 70. .492 27 .904 34, .940 1, .00 32. .90 1SG2643
ATOM 2643 O SER 338 71, .448 28 .415 35. .520 1. .00 32. .90 1SG2644
ATOM 2644 N ILE 339 69, .284 28, .489 34. .880 1. .00 33, .91 1SG2645
ATOM 2645 CA ILE 339 69. .053 29, .751 35. .512 1. .00 33, .91 1SG2646
ATOM 2646 CB ILE 339 68. .442 30, .762 34. .586 1. .00 33, .91 1SG2647
ATOM 2647 CG2 ILE 339 68. .175 32 .041 35. .396 1, .00 33 .91 1SG2648
ATOM 2648 CGI ILE 339 69. .329 30 .982 33. .350 1, .00 33 .91 1SG2649
ATOM 2649 CDl ILE 339 70. .724 31 .504 33. .677 1, .00 33, .91 1SG2650
ATOM 2650 C ILE 339 68. .025 29, .499 36. .565 1, .00 33, .91 1SG2651
ATOM 2651 O ILE 339 66. .917 29 .063 36. .262 1 .00 33 .91 1SG2652
ATOM 2652 N MET 340 68, .360 29 .765 37. .840 1, .00 36 .82 1SG2653
ATOM 2653 CA MET 340 67, .380 29, .529 38. .859 1, .00 36 .82 1SG2654
ATOM 2654 CB MET 340 67, .823 28, .484 39. .896 1. .00 36, .82 1SG2655
ATOM 2655 CG MET 340 67, .944 27 .086 39. .283 1, .00 36 .82 1SG2656
ATOM 2656 SD MET 340 68, .462 25 .774 40. .428 1, .00 36 .82 1SG2657
ATOM 2657 CE MET 340 68, .387 24, .451 39. .186 1, .00 36, .82 1SG2658
ATOM 2658 C MET 340 67. .115 30, .825 39. .553 1. .00 36, .82 1SG2659
ATOM 2659 O MET 340 68. .033 31 .599 39. .822 1, .00 36 .82 1SG2660
ATOM 2660 N MET 341 65. .829 31 .100 39. .848 1. .00 42 .12 1SG2661
ATOM 2661 CA MET 341 65. .475 32 .330 40, .491 1, .00 42, .12 1SG2662
ATOM 2662 CB MET 341 64. .264 33, .036 39, .858 1, .00 42, .12 1SG2663
ATOM 2663 CG MET 341 63 .916 34 .364 40 .534 1 .00 42 .12 1SG2664
ATOM 2664 SD MET 341 62. .486 35 .226 39, .814 1, .00 42, .12 1SG2665
ATOM 2665 CE MET 341 63, .361 35, .763 38, .315 1, .00 42, .12 1SG2666
ATOM 2666 C MET 341 65, .152 32, .022 41. .910 1, .00 42, .12 1SG2667
ATOM 2667 0 MET 341 64. .526 31 .010 42. .226 1, .00 42 .12 1SG2668
ATOM 2668 N LEU 342 65. .610 32 .911 42. .806 1, .00 47, .80 1SG2669
ATOM 2669 CA LEU 342 65. .477 32 .694 44, .207 1, .00 47, .80 1SG2670
ATOM 2670 CB LEU 342 66. .857 32, .600 44, .846 1, .00 47. .80 1SG2671
ATOM 2671 CG LEU 342 66. .790 32 .019 46 .240 1, .00 47. .80 1SG2672
ATOM 2672 CD2 LEU 342 68. .102 32 .233 47, .010 1, .00 47. .80 1SG2673
ATOM 2673 CDl LEU 342 66, .344 30 .560 46, .091 1. .00 47, .80 1SG2674
ATOM 2674 C LEU 342 64. .859 33, .918 44 , .796 1. .00 47. .80 1SG2675
ATOM 2675 O LEU 342 65, .054 35 .021 44, .290 1, .00 47. .80 1SG2676
ATOM 2676 N THR 343 64, .099 33 .756 45, .896 1, .00 50, .93 1SG2677
ATOM 2677 CA THR 343 63 , .567 34. .901 46. .568 1, .00 50. .93 1SG2678
ATOM 2678 CB THR 343 62. .137 34. .745 46. .996 1, .00 50. .93 1SG2679
ATOM 2679 OGl THR 343 62. .016 33 .671 47, .918 1, .00 50. .93 1SG2680
ATOM 2680 CG2 THR 343 61, .275 34 .478 45, .751 1, .00 50. .93 1SG2681
ATOM 2681 C THR 343 64. .395 35. .018 47, .798 1, .00 50. .93 1SG2682
ATOM 2682 O THR 343 64. .738 34. .011 48. .415 1. .00 50. .93 1SG2683
ATOM 2683 N GLN 344 64 , .780 36. .251 48. .171 1. ,00 56, ,62 1SG2684 ATOM 2684 CA GLN 344 65..605 36,.369 49,.337 1..00 56,.62 1SG2685
ATOM 2685 CB GLN 344 66. .743 37, .392 49 .174 1. .00 56, .62 1SG2686
ATOM 2686 CG GLN 344 67 .752 37 .014 48 .088 1. .00 56, .62 1SG2687
ATOM 2687 CD GLN 344 68. .815 38 .102 48 .033 1, .00 56, .62 1SG2688
ATOM 2688 OEl GLN 344 69, .043 38, .713 46 . .991 1, .00 56, .62 1SG2689
ATOM 2689 NE2 GLN 344 69, .487 38, .351 49 .189 1, .00 56, .62 1SG2690
ATOM 2690 C GLN 344 64 .736 36 .852 50 .451 1 .00 56, .62 1SG2691
ATOM 2691 O GLN 344 64 .267 37 .987 50 .434 1 .00 56, .62 1SG2692
ATOM 2692 N PRO 345 64, .506 36, .015 51 .425 1, .00 63, .06 1SG2693
ATOM 2693 CA PRO 345 63, .706 36, .459 52 .531 1. .00 63, .06 1SG2694
ATOM 2694 CD PRO 345 64, .225 34, .622 51 .115 1, .00 63, .06 1SG2695
ATOM 2695 CB PRO 345 63 .169 35, .209 53 .215 1 .00 63, .06 1SG2696
ATOM 2696 CG PRO 345 63, ,099 34 , .190 52, .067 1 .00 63 .06 1SG2697
ATOM 2697 C PRO 345 64, .456 37. .384 53 .421 1, .00 63, .06 1SG2698
ATOM 2698 O PRO 345 65, .677 37. .469 53 .286 1, .00 63, .06 1SG2699
ATOM 2699 N LYS 346 63, .727 38. .096 54 .311 1, .00 67, .36 1SG2700
ATOM 2700 CA LYS 346 64, .324 39. .045 55 .206 1, .00 67 .36 1SG2701
ATOM 2701 CB LYS 346 63. .290 39. .893 55, .967 1, .00 67, .36 1SG2702
ATOM 2702 CG LYS 346 62. .464 40. .805 55 .059 1, .00 67, .36 1SG2703
ATOM 2703 CD LYS 346 61, .229 41. .396 55, .744 1, .00 67, .36 1SG2704
ATOM 2704 CE LYS 346 60. .403 42. .309 54 .836 1, .00 67, .36 1SG2705
ATOM 2705 NZ LYS 346 59. .678 41. .502 53, .830 1. .00 67. .36 1SG2706
ATOM 2706 C LYS 346 65. .110 38. .283 56, .216 1. .00 67. .36 1SG2707
ATOM 2707 O LYS 346 64 .684 38 .051 57 .346 1 .00 67 .36 1SG2708
ATOM 2708 N ASN 347 66 .308 37 .889 55 .776 1 .00 70 .88 1SG2709
ATOM 2709 CA ASN 347 67, .330 37. .157 56 .446 1. .00 70 .88 1SG2710
ATOM 2710 CB ASN 347 67 .145 35. .628 56 .486 1, .00 70 .88 1SG2711
ATOM 2711 CG ASN 347 65 .792 35 .228 57 .037 1 .00 70 .88 1SG2712
ATOM 2712 ODl ASN 347 65 .005 34 .635 56 .300 1 .00 70 .88 1SG2713
ATOM 2713 ND2 ASN 347 65, .517 35, .534 58, .333 1, .00 70 .88 1SG2714
ATOM 2714 C ASN 347 68. .352 37, .273 55 .384 1, .00 70. .88 1SG2715
ATOM 2715 O ASN 347 68. .800 38, .353 55 .010 1, .00 70, .88 1SG2716
ATOM 2716 N SER 348 68 .731 36, .105 54 .866 1, .00 67, .09 1SG2717
ATOM 2717 CA SER 348 69. .558 36. .030 53, .714 1 .00 67 .09 1SG2718
ATOM 2718 CB SER 348 71. .057 36, .006 54, .052 1, .00 67, .09 1SG2719
ATOM 2719 OG SER 348 71, .822 35, .927 52 .860 1, .00 67, .09 1SG2720
ATOM 2720 C SER 348 69, .204 34, .703 53 .159 1, .00 67, .09 1SG2721
ATOM 2721 O SER 348 69. .903 34. .146 52 .314 1 .00 67. .09 1SG2722
ATOM 2722 N THR 349 68. .055 34. .181 53, .624 1, .00 60. .84 1SG2723
ATOM 2723 CA THR 349 67. .653 32. .870 53. .228 1. .00 60, .84 1SG2724
ATOM 2724 CB THR 349 66. .542 32. .295 54. .057 1, .00 60. .84 1SG2725
ATOM 2725 OGl THR 349 66. .284 30. .953 53. .671 1. .00 60. .84 1SG2726
ATOM 2726 CG2 THR 349 65. .287 33. ,155 53. .884 1. .00 60. .84 1SG2727
ATOM 2727 C THR 349 67, .263 32. ,898 51, .787 1. .00 60. .84 1SG2728
ATOM 2728 O THR 349 66. .963 33. .945 51, .218 1. .00 60. .84 1SG2729
ATOM 2729 N VAL 350 67. .316 31, .701 51 .182 1, .00 55. .30 1SG2730
ATOM 2730 CA VAL 350 67. .136 31. .363 49, .799 1. .00 55. .30 1SG2731
ATOM 2731 CB VAL 350 68, .280 30. .428 49, .480 1. .00 55. .30 1SG2732
ATOM 2732 CGI VAL 350 68. .041 29. .566 48, .240 1. .00 55. .30 1SG2733
ATOM 2733 CG2 VAL 350 69. .553 31. .286 49 .402 1, .00 55. .30 1SG2734
ATOM 2734 C VAL 350 65. .846 30. ,610 49, .631 1. .00 55, .30 1SG2735
ATOM 2735 O VAL 350 65. .657 29. ,555 50, .231 1. .00 55. ,30 1SG2736
ATOM 2736 N GLU 351 64. .914 31. ,123 48, .796 1. .00 50. .59 1SG2737
ATOM 2737 CA GLU 351 63. .708 30. ,374 48, .557 1. .00 50. .59 1SG2738
ATOM 2738 CB GLU 351 62. 432 31. .091 49, .028 1. .00 50. .59 1SG2739
ATOM 2739 CG GLU 351 61. 202 30. ,185 49. .020 1. .00 50. .59 1SG2740
ATOM 2740 CD GLU 351 61. .353 29. ,187 50. .159 1. ,00 50. .59 1SG2741 ATOM 2741 OEl GLU 351 62..381 29..269 50..884 1..00 50..59 1SG2742
ATOM 2742 OE2 GLU 351 60. .445 28. .329 50. .321 1. .00 50. .59 1SG2743
ATOM 2743 C GLU 351 63. .607 30. .193 47. .070 1. .00 50. .59 1SG2744
ATOM 2744 O GLU 351 63. .461 31. .167 46. .333 1. ,00 50. ,59 1SG2745
ATOM 2745 N THR 352 63. .693 28, .936 46. .583 1. .00 48. .27 1SG2746
ATOM 2746 CA THR 352 63. .746 28, .706 45. .161 1. .00 48. .27 1SG2747
ATOM 2747 CB THR 352 64. .294 27, .356 44. .788 1. .00 48. .27 1SG2748
ATOM 2748 OGl THR 352 64, .423 27, .253 43, .377 1, .00 48. .27 1SG2749
ATOM 2749 CG2 THR 352 63, .364 26, .258 45, .329 1, .00 48. .27 1SG2750
ATOM 2750 C THR 352 62. .409 28, .875 44. .509 1. .00 48. .27 1SG2751
ATOM 2751 O THR 352 61. .455 28. .161 44. .815 1. .00 48. .27 1SG2752
ATOM 2752 N ILE 353 62. .299 29. .887 43. .619 1, .00 46, .22 1SG2753
ATOM 2753 CA ILE 353 61, .089 30, .104 42. .882 1. .00 46, .22 1SG2754
ATOM 2754 CB ILE 353 60. .946 31, .511 42. .362 1. .00 46, .22 1SG2755
ATOM 2755 CG2 ILE 353 62, .046 31, .782 41. .328 1, .00 46, .22 1SG2756
ATOM 2756 CGI ILE 353 59, .524 31, .733 41, .824 1. .00 46, .22 1SG2757
ATOM 2757 CDl ILE 353 58, .450 31, .696 42, .910 1. .00 46, .22 1SG2758
ATOM 2758 C ILE 353 60. .924 29, .139 41. .733 1. .00 46, .22 1SG2759
ATOM 2759 O ILE 353 59, .891 28, .481 41. .619 1, .00 46, .22 1SG2760
ATOM 2760 N VAL 354 61, .945 29, .009 40. .851 1, .00 42, .58 1SG2761
ATOM 2761 CA VAL 354 61, .798 28, .164 39. .692 1, .00 42, .58 1SG2762
ATOM 2762 CB VAL 354 60, .893 28, .766 38 .656 1, .00 42 .58 1SG2763
ATOM 2763 CGI VAL 354 61, .545 30, .058 38. .139 1, .00 42, .58 1SG2764
ATOM 2764 CG2 VAL 354 60, .615 27, .728 37, .558 1, .00 42, .58 1SG2765
ATOM 2765 C VAL 354 63, .140 27, .959 39, .046 1, .00 42, .58 1SG2766
ATOM 2766 O VAL 354 64, .086 28, .708 39, .285 1 .00 42 .58 1SG2767
ATOM 2767 N SER 355 63, .251 26, .919 38, .191 1, .00 38 .97 1SG2768
ATOM 2768 CA SER 355 64, .492 26, .657 37, .514 1, .00 38, .97 1SG2769
ATOM 2769 CB SER 355 65 .068 25 .259 37 .802 1 .00 38 .97 1SG2770
ATOM 2770 OG SER 355 64, .207 24, .257 37 .281 1 .00 38 .97 1SG2771
ATOM 2771 C SER 355 64, .239 26, .739 36, .041 1 .00 38 .97 1SG2772
ATOM 2772 O SER 355 63, .223 26, .252 35, .547 1, .00 38, .97 1SG2773
ATOM 2773 N MET 356 65, .169 27 .368 35 .294 1 .00 37 .71 1SG2774
ATOM 2774 CA MET 356 64, .989 27, .504 33, .878 1, .00 37 .71 1SG2775
ATOM 2775 CB MET 356 64. .925 28. .962 33, .395 1, .00 37 .71 1SG2776
ATOM 2776 CG MET 356 64. .616 29 .075 31 .902 1 .00 37 .71 1SG2777
ATOM 2777 SD MET 356 64. .533 30, .775 31 .272 1 .00 37 .71 1SG2778
ATOM 2778 CE MET 356 66. .332 31, .012 31, .205 1, .00 37, .71 1SG2779
ATOM 2779 C MET 356 66. .158 26. .883 33, .189 1, .00 37, .71 1SG2780
ATOM 2780 O MET 356 67, .280 26. .891 33 .697 1 .00 37 .71 1SG2781
ATOM 2781 N ASP 357 65, .903 26. .305 32, .001 1, .00 36, .26 1SG2782
ATOM 2782 CA ASP 357 66, .958 25. .706 31, .244 1, .00 36, .26 1SG2783
ATOM 2783 CB ASP 357 66, .678 24. .254 30 .831 1 .00 36 .26 1SG2784
ATOM 2784 CG ASP 357 67, .938 23, .682 30, .198 1 .00 36, .26 1SG2785
ATOM 2785 ODl ASP 357 68, .963 24, .412 30, .130 1, .00 36, .26 1SG2786
ATOM 2786 OD2 ASP 357 67. .887 22. .498 29. .770 1, .00 36. .26 1SG2787
ATOM 2787 C ASP 357 67. .095 26. .496 29. .991 1 .00 36. .26 1SG2788
ATOM 2788 O ASP 357 66. .178 26, .561 29, .172 1, .00 36, .26 1SG2789
ATOM 2789 N PHE 358 68. .260 27. .136 29, .818 1, .00 36, .76 1SG2790
ATOM 2790 CA PHE 358 68, .459 27. .892 28, .628 1, .00 36, .76 1SG2791
ATOM 2791 CB PHE 358 68, .664 29. .405 28, .861 1, .00 36, .76 1SG2792
ATOM 2792 CG PHE 358 70, .091 29. .818 29, .071 1, .00 36. .76 1SG2793
ATOM 2793 CDl PHE 358 71. ,040 29. .813 28. .068 1. .00 36. .76 1SG2794
ATOM 2794 CD2 PHE 358 70. .478 30. .241 30. .323 1. .00 36. .76 1SG2795
ATOM 2795 CE1 PHE 358 72. .333 30. .212 28. .308 1. .00 36, .76 1SG2796
ATOM 2796 CE2 PHE 358 71. .767 30. .646 30. .572 1. .00 36, .76 1SG2797
ATOM 2797 CZ PHE 358 72. .698 30. .636 29. .562 1. .00 36, .76 1SG2798 ATOM 2798 C PHE 358 69..572 27..306 27..833 1..00 36..76 1SG2799
ATOM 2799 O PHE 358 70, .515 26, .726 28, .368 1. .00 36. .76 1SG2800
ATOM 2800 N VAL 359 69, .452 27. .446 26. .499 1. .00 37. .44 1SG2801
ATOM 2801 CA VAL 359 70. .455 26, .997 25. .584 1. .00 37. .44 1SG2802
ATOM 2802 CB VAL 359 70, .191 25. .627 25. .032 1. .00 37. .44 1SG2803
ATOM 2803 CGI VAL 359 70, .165 24. .622 26. .197 1. .00 37. .44 1SG2804
ATOM 2804 CG2 VAL 359 68, .892 25 .676 24. .210 1, .00 37, .44 1SG2805
ATOM 2805 C VAL 359 70, .398 27, .947 24. .433 1. .00 37. .44 1SG2806
ATOM 2806 O VAL 359 69, .396 28. .635 24. .240 1. .00 37. .44 1SG2807
ATOM 2807 N ALA 360 71, .483 28. .023 23, .639 1. .00 37, .01 1SG2808
ATOM 2808 CA ALA 360 71. .480 28. .931 22 , .528 1. .00 37. .01 1SG2809
ATOM 2809 CB ALA 360 71 .730 30, .393 22, .927 1. .00 37. .01 1SG2810
ATOM 2810 C ALA 360 72. .595 28, .536 21, .612 1. .00 37. .01 1SG2811
ATOM 2811 O ALA 360 73, .269 27. .533 21. .834 1. .00 37. .01 1SG2812
ATOM 2812 N SER 361 72 .773 29. .308 20, .521 1. .00 38. .55 1SG2813
ATOM 2813 CA SER 361 73, .845 29. .097 19, .590 1. .00 38. .55 1SG2814
ATOM 2814 CB SER 361 73, .379 28. .669 18. .188 1. .00 38. .55 1SG2815
ATOM 2815 OG SER 361 74, .498 28. .488 17. .331 1, .00 38 .55 1SG2816
ATOM 2816 C SER 361 74, .511 30. .429 19, .453 1. .00 38. .55 1SG2817
ATOM 2817 O SER 361 73 .853 31. .464 19 .553 1. .00 38 .55 1SG2818
ATOM 2818 N THR 362 75 .841 30. .446 19, .236 1. .00 38 .63 1SG2819
ATOM 2819 CA THR 362 76, .516 31, .709 19. .217 1. .00 38. .63 1SG2820
ATOM 2820 CB THR 362 77 .136 31, .988 20. .547 1. .00 38 .63 1SG2821
ATOM 2821 OGl THR 362 78, .117 31, .000 20. .825 1, .00 38 .63 1SG2822
ATOM 2822 CG2 THR 362 76, .031 31, .938 21, .616 1. .00 38. .63 1SG2823
ATOM 2823 C THR 362 77 .644 31, .655 18, .240 1. .00 38 .63 1SG2824
ATOM 2824 O THR 362 78, .052 30, .587 17, .791 1. .00 38. .63 1SG2825
ATOM 2825 N SER 363 78 .192 32 .837 17, .897 1. .00 38 .08 1SG2826
ATOM 2826 CA SER 363 79 .308 32, .873 17, .004 1, .00 38 .08 1SG2827
ATOM 2827 CB SER 363 79, .143 33, .878 15, .853 1. .00 38. .08 1SG2828
ATOM 2828 OG SER 363 80 .292 33 .848 15 .021 1, .00 38 .08 1SG2829
ATOM 2829 C SER 363 80, .480 33, .315 17, .808 1. .00 38. .08 1SG2830
ATOM 2830 O SER 363 80, .373 34. .238 18 , .613 1. .00 38, .08 1SG2831
ATOM 2831 N VAL 364 81 .637 32. .644 17, .633 1, .00 37 .87 1SG2832
ATOM 2832 CA VAL 364 82, .775 33. .092 18, .375 1. .00 37, .87 1SG2833
ATOM 2833 CB VAL 364 83 .360 32, .066 19 .301 1, .00 37, .87 1SG2834
ATOM 2834 CGI VAL 364 82 .322 31, .772 20, .399 1, .00 37 .87 1SG2835
ATOM 2835 CG2 VAL 364 83, .790 30, .838 18 , .481 1. .00 37, .87 1SG2836
ATOM 2836 C VAL 364 83 .826 33, .538 17, .412 1, .00 37 .87 1SG2837
ATOM 2837 O VAL 364 84, .321 32, .761 16, .596 1. .00 37, .87 1SG2838
ATOM 2838 N GLY 365 84. .172 34. .839 17. .480 1. .00 36, .89 1SG2839
ATOM 2839 CA GLY 365 85. .185 35. .382 16, .625 1. .00 36, .89 1SG2840
ATOM 2840 C GLY 365 86. .505 35. .157 17. .285 1. .00 36, .89 1SG2841
ATOM 2841 O GLY 365 86 .597 35. .102 18. .512 1. .00 36, .89 1SG2842
ATOM 2842 N LEU 366 87, .576 35, .041 16. .476 1. .00 38, .92 1SG2843
ATOM 2843 CA LEU 366 88, .876 34. .841 17. .044 1. ,00 38. .92 1SG2844
ATOM 2844 CB LEU 366 89 .422 33, .422 16, .823 1, .00 38, .92 1SG2845
ATOM 2845 CG LEU 366 88, .549 32. .348 17. .495 1. .00 38. .92 1SG2846
ATOM 2846 CD2 LEU 366 89, .281 31. .005 17. .571 1. .00 38. .92 1SG2847
ATOM 2847 CDl LEU 366 87, .172 32. .237 16. .820 1, .00 38. .92 1SG2848
ATOM 2848 C LEU 366 89, .836 35. .805 16. .421 1. .00 38. .92 1SG2849
ATOM 2849 O LEU 366 89, .848 35. .997 15. .205 1. .00 38. .92 1SG2850
ATOM 2850 N -VAL 367 90, .675 36. .435 17. .269 1. .00 40. .30 1SG2851
ATOM 2851 CA VAL 367 91, .650 37. ,393 16. ,831 1. ,00 40. ,30 1SG2852
ATOM 2852 CB VAL 367 91, .246 38. .815 17. .081 1. .00 40. .30 1SG2853
ATOM 2853 CGI VAL 367 89, .973 39. .119 16. .274 1. .00 40. .30 1SG2854
ATOM 2854 CG2 VAL 367 91. .094 39. ,017 18. ,598 1. .00 40. ,30 1SG2855 ATOM 2855 C VAL 367 92..877 37,.159 17..649 1..00 40..30 1SG2856
ATOM 2856 O VAL 367 92. .863 36. .374 18. .596 1, .00 40. .30 1SG2857
ATOM 2857 N ILE 368 93. .994 37. .820 17. .286 1. .00 43. .20 1SG2858
ATOM 2858 CA ILE 368 95. .195 37, .601 18. .037 1. .00 43. .20 1SG2859
ATOM 2859 CB ILE 368 96. .203 36, .807 17. .245 1. .00 43. .20 1SG2860
ATOM 2860 CG2 ILE 368 96. .749 37, .705 16, .124 1. .00 43. .20 1SG2861
ATOM 2861 CGI ILE 368 97, .283 36, .191 18. .144 1. .00 43, .20 1SG2862
ATOM 2862 CDl ILE 368 98, .119 37, .215 18, .896 1. .00 43. .20 1SG2863
ATOM 2863 C ILE 368 95, .773 38, .933 18, .408 1. .00 43. .20 1SG2864
ATOM 2864 O ILE 368 95, .855 39, .845 17, .586 1. .00 43. .20 1SG2865
ATOM 2865 N LEU 369 96. .162 39, .088 19, .689 1. .00 46, .92 1SG2866
ATOM 2866 CA LEU 369 96 .787 40 .295 20 .135 1. .00 46, .92 1SG2867
ATOM 2867 CB LEU 369 95 .950 41 .065 21 .180 1. .00 46 .92 1SG2868
ATOM 2868 CG LEU 369 96 .456 42 .479 21, .556 1. .00 46 .92 1SG2869
ATOM 2869 CD2 LEU 369 97 .924 42 .503 22, .012 1. .00 46 .92 1SG2870
ATOM 2870 CDl LEU 369 95 .528 43 .117 22 .599 1. .00 46 .92 1SG2871
ATOM 2871 C LEU 369 98 .053 39 .842 20, .782 1. .00 46 .92 1SG2872
ATOM 2872 O LEU 369 98 .050 38 .917 21, .595 1, .00 46 .92 1SG2873
ATOM 2873 N GLY 370 99 .181 40 .478 20, .422 1, .00 49 .71 1SG2874
ATOM 2874 CA GLY 370 100 .421 40 .077 21 .007 1, .00 49 .71 1SG2875
ATOM 2875 C GLY 370 100 .618 38 .633 20 .675 1, .00 49 .71 1SG2876
ATOM 2876 O GLY 370 100 .579 38 .230 19 .516 1, .00 49 .71 1SG2877
ATOM 2877 N GLN 371 100 .939 37 .858 21 .724 1 .00 55 .62 1SG2878
ATOM 2878 CA GLN 371 101. .155 36 .440 21 .776 1, .00 55 .62 1SG2879
ATOM 2879 CB GLN 371 102, .012 36 .053 22 .992 1, .00 55 .62 1SG2880
ATOM 2880 CG GLN 371 101, .324 36 .389 24 .319 1, .00 55 .62 1SG2881
ATOM 2881 CD GLN 371 102 .266 36 .052 25 .467 1, .00 55 .62 1SG2882
ATOM 2882 OEl GLN 371 103 .419 36 .480 25 .492 1, .00 55 .62 1SG2883
ATOM 2883 NE2 GLN 371 101. .759 35 .263 26 .452 1, .00 55 .62 1SG2884
ATOM 2884 C GLN 371 99. .884 35 .639 21, .880 1, .00 55, .62 1SG2885
ATOM 2885 0 GLN 371 99, .883 34 .444 21, .584 1, .00 55 .62 1SG2886
ATOM 2886 N ARG 372 98, .796 36 .244 22, .399 1, .00 57 .51 1SG2887
ATOM 2887 CA ARG 372 97, .642 35 .470 22, .787 1, .00 57, .51 1SG2888
ATOM 2888 CB ARG 372 96, .996 35, .994 24, .075 1, .00 57 .51 1SG2889
ATOM 2889 CG ARG 372 96, .605 37 .466 23 .983 1, .00 57, .51 1SG2890
ATOM 2890 CD ARG 372 96, .019 38. .011 25, .283 1, .00 57. .51 1SG2891
ATOM 2891 NE ARG 372 95, .875 39, .483 25, .123 1, .00 57. .51 1SG2892
ATOM 2892 CZ ARG 372 96, .899 40 .299 25, .505 1, .00 57, .51 1SG2893
ATOM 2893 NHl ARG 372 98, .029 39, .761 26, .050 1. .00 57. .51 1SG2894
ATOM 2894 NH2 ARG 372 96, .794 41. .651 25, .343 1. .00 57. .51 1SG2895
ATOM 2895 C ARG 372 96, .558 35, .321 21, .765 1, .00 57. .51 1SG2896
ATOM 2896 O ARG 372 96, .485 36, .030 20, .763 1. .00 57. .51 1SG2897
ATOM 2897 N LEU 373 95, .687 34, .320 22, .030 1. .00 55. .44 1SG2898
ATOM 2898 CA LEU 373 94. .550 33, .995 21, .223 1. .00 55. .44 1SG2899
ATOM 2899 CB LEU 373 94. .445 32. .473 20. .993 1. .00 55. .44 1SG2900
ATOM 2900 CG LEU 373 93 , .264 31. .970 20. .140 1. .00 55. .44 1SG2901
ATOM 2901 CD2 LEU 373 91. .911 32. .205 20. .824 1. .00 55. .44 1SG2902
ATOM 2902 CDl LEU 373 93. .445 30, .482 19. .810 1. .00 55. .44 1SG2903
ATOM 2903 C LEU 373 93. .361 34 , .490 21. .984 1. .00 55. .44 1SG2904
ATOM 2904 O LEU 373 93. .078 34. .026 23. .087 1. .00 55. .44 1SG2905
ATOM 2905 N VAL 374 92. .633 35. .461 21. .400 1. .00 52. .25 1SG2906
ATOM 2906 CA VAL 374 91. .517 36. .063 22. .071 1. .00 52. ,25 1SG2907
ATOM 2907 CB VAL 374 91. .682 37. .552 22. .224 1. ,00 52. .25 1SG2908
ATOM 2908 CGI VAL 374 90. .399 38. .144 22. .793 1. .00 52. .25 1SG2909
ATOM 2909 CG2 VAL 374 92. .888 37. .837 23. .126 1. .00 52. .25 1SG2910
ATOM 2910 C VAL 374 90. .297 35. .827 21. .234 1. ,00 52. .25 1SG2911
ATOM 2911 O VAL 374 90, .396 35. .623 20. .025 1. .00 52. .25 1SG2912 ATOM 2912 N CYS 375 89..106 35..815 21..872 1..00 45..54 1SG2913
ATOM 2913 CA CYS 375 87. .901 35. .607 21. .125 1. .00 45. .54 1SG2914
ATOM 2914 CB CYS 375 87. .402 34. .151 21. .167 1. .00 45. .54 1SG2915
ATOM 2915 SG CYS 375 88. .615 32. .966 20. .510 1. .00 45. .54 1SG2916
ATOM 2916 C CYS 375 86, .810 36. .439 21. .726 1. .00 45. .54 1SG2917
ATOM 2917 O CYS 375 86, .969 37. .028 22. .795 1. .00 45. .54 1SG2918
ATOM 2918 N SER 376 85, .661 36, .509 21, .020 1. .00 43. .25 1SG2919
ATOM 2919 CA SER 376 84, .510 37, .220 21, .499 1. .00 43. .25 1SG2920
ATOM 2920 CB SER 376 84, .269 38, .563 20, .789 1. .00 43. .25 1SG2921
ATOM 2921 OG SER 376 83, .985 38, .339 19, .416 1. .00 43. .25 1SG2922
ATOM 2922 C SER 376 83, .333 36, .342 21, .220 1. .00 43. .25 1SG2923
ATOM 2923 O SER 376 83, .315 35, .588 20, .248 1. .00 43. .25 1SG2924
ATOM 2924 N LEU 377 82, .310 36, .411 22, .085 1. .00 44. .40 1SG2925
ATOM 2925 CA LEU 377 81, .154 35, .575 21. .952 1. .00 44. .40 1SG2926
ATOM 2926 CB LEU 377 80, .931 34, .777 23, .254 1. .00 44. .40 1SG2927
ATOM 2927 CG LEU 377 79, .706 33, .857 23 , .303 1. .00 44, .40 1SG2928
ATOM 2928 CD2 LEU 377 79, .661 32. .920 22, .089 1. .00 44, .40 1SG2929
ATOM 2929 CDl LEU 377 78, .429 34, .690 23, .475 1. .00 44, .40 1SG2930
ATOM 2930 C LEU 377 79, .968 36, .454 21, .684 1. .00 44, .40 1SG2931
ATOM 2931 O LEU 377 79 .848 37, .536 22, .254 1. .00 44, .40 1SG2932
ATOM 2932 N SER 378 79 .069 36, .011 20, .777 1. .00 45, .66 1SG2933
ATOM 2933 CA SER 378 77, .862 36, .736 20, .490 1. .00 45, .66 1SG2934
ATOM 2934 CB SER 378 77, .892 37, .467 19, .131 1. .00 45, .66 1SG2935
ATOM 2935 OG SER 378 77, .957 36, .536 18, .060 1. .00 45, .66 1SG2936
ATOM 2936 C SER 378 76, .777 35, .707 20, .437 1, .00 45, .66 1SG2937
ATOM 2937 O SER 378 76, .982 34, .633 19, .877 1. .00 45, .66 1SG2938
ATOM 2938 N LEU 379 75, .588 35, .984 21. .014 1. .00 49, .14 1SG2939
ATOM 2939 CA LEU 379 74, .581 34, .956 20, .990 1. .00 49, .14 1SG2940
ATOM 2940 CB LEU 379 73, .895 34, .602 22, .327 1, .00 49, .14 1SG2941
ATOM 2941 CG LEU 379 74, .812 34, .034 23, .423 1. .00 49, .14 1SG2942
ATOM 2942 CD2 LEU 379 74, .033 33, .141 24, .401 1. .00 49, .14 1SG2943
ATOM 2943 CDl LEU 379 75, .592 35, .157 24, .116 1. .00 49, .14 1SG2944
ATOM 2944 C LEU 379 73, .470 35, .326 20, .070 1. .00 49, .14 1SG2945
ATOM 2945 O LEU 379 73, .381 36, .446 19, .567 1. .00 49, .14 1SG2946
ATOM 2946 N ASN 380 72, .587 34, .337 19, .837 1. .00 50, .48 1SG2947
ATOM 2947 CA ASN 380 71. .457 34, .492 18, .980 1. .00 50, .48 1SG2948
ATOM 2948 CB ASN 380 71, .438 33 , .482 17, .822 1. .00 50. .48 1SG2949
ATOM 2949 CG ASN 380 70, .625 34 , .111 16, .706 1. .00 50. .48 1SG2950
ATOM 2950 ODl ASN 380 69, .726 34. .912 16, .964 1. .00 50. .48 1SG2951
ATOM 2951 ND2 ASN 380 70, .957 33. .755 15, .436 1. .00 50. .48 1SG2952
ATOM 2952 C ASN 380 70, .245 34, .282 19, .839 1. .00 50. .48 1SG2953
ATOM 2953 O ASN 380 70, .229 34, .697 20, .996 1. .00 50. .48 1SG2954
ATOM 2954 N ARG 381 69, .198 33. .642 19, .277 1. .00 51. .63 1SG2955
ATOM 2955 CA ARG 381 67, .938 33, .416 19, .936 1. .00 51. .63 1SG2956
ATOM 2956 CB ARG 381 67, .031 32, .446 19. .160 1. .00 51. .63 1SG2957
ATOM 2957 CG ARG 381 66, .918 32, .734 17, .663 1. .00 51. .63 1SG2958
ATOM 2958 CD ARG 381 65, .571 33 , .295 17, .210 1. .00 51. .63 1SG2959
ATOM 2959 NE ARG 381 65, .605 34. .765 17, .439 1. .00 51. .63 1SG2960
ATOM 2960 CZ ARG 381 66, .282 35. .564 16, .564 1. .00 51. .63 1SG2961
ATOM 2961 NHl ARG 381 66, .983 35. .008 15, .534 1. .00 51. .63 1SG2962
ATOM 2962 NH2 ARG 381 66, .284 36. .919 16, .726 1. .00 51. .63 1SG2963
ATOM 2963 C ARG 381 68. .225 32. .721 21. .226 1. ,00 51. .63 1SG2964
ATOM 2964 O ARG 381 69. .154 31. .923 21, .322 1. .00 51. .63 1SG2965
ATOM 2965 N PHE 382 67. .425 33, .018 22, .266 1. .00 50. ,54 1SG2966
ATOM 2966 CA PHE 382 67. .660 32. .424 23 , .546 1. ,00 50. ,54 1SG2967
ATOM 2967 CB PHE 382 67. .653 33. .541 24. .598 1. ,00 50. ,54 1SG2968
ATOM 2968 CG PHE 382 68. .441 33. .166 25. .788 1. ,00 50. ,54 1SG2969 ATOM 2969 CDl PHE 382 69.778 33.480 25.811 1..00 50.54 1SG2970
ATOM 2970 CD2 PHE 382 67 .862 32 .522 26. .853 1. .00 50, .54 1SG2971
ATOM 2971 CE1 PHE 382 70, .549 33. .168 26. .897 1. ,00 50, .54 1SG2972
ATOM 2972 CE2 PHE 382 68 .627 32 .208 27 .945 1. .00 50, .54 1SG2973
ATOM 2973 CZ PHE 382 69 .959 32 .532 27. .959 1. .00 50, .54 1SG2974
ATOM 2974 C PHE 382 66 .470 31 .547 23. .765 1. .00 50, .54 1SG2975
ATOM 2975 O PHE 382 65 .340 32 .002 23 .607 1. .00 50 .54 1SG2976
ATOM 2976 N ARG 383 66 .660 30 .258 24. .108 1. .00 48, .07 1SG2977
ATOM 2977 CA ARG 383 65 .466 29 .485 24 .274 1. .00 48 .07 1SG2978
ATOM 2978 CB ARG 383 65 .273 28 .367 23 .226 1. .00 48 .07 1SG2979
ATOM 2979 CG ARG 383 66 .395 27 .340 23. .098 1. .00 48, .07 1SG2980
ATOM 2980 CD ARG 383 66 .430 26 .697 21 .706 1. .00 48 .07 1SG2981
ATOM 2981 NE ARG 383 65 .043 26 .266 21. .360 1. .00 48 .07 1SG2982
ATOM 2982 CZ ARG 383 64 .713 26 .019 20 .058 1. .00 48 .07 1SG2983
ATOM 2983 NHl ARG 383 65 .667 26 .105 19 .086 1. .00 48 .07 1SG2984
ATOM 2984 NH2 ARG 383 63 .428 25 .701 19. .720 1. .00 48, .07 1SG2985
ATOM 2985 C ARG 383 65 .373 28 .996 25 .681 1. .00 48 .07 1SG2986
ATOM 2986 O ARG 383 66 .344 28 .528 26 .275 1. .00 48 .07 1SG2987
ATOM 2987 N LEU 384 64 .162 29. .142 26. .253 1. .00 44, .55 1SG2988
ATOM 2988 CA LEU 384 63 .904 28 .833 27 .625 1, .00 44 .55 1SG2989
ATOM 2989 CB LEU 384 63 .024 29 .886 28 .323 1, .00 44 .55 1SG2990
ATOM 2990 CG LEU 384 63 .637 31 .297 28 .380 1, .00 44. .55 1SG2991
ATOM 2991 CD2 LEU 384 62 .764 32 .236 29 .226 1, .00 44 .55 1SG2992
ATOM 2992 CDl LEU 384 63, .889 31. .861 26 .973 1. .00 44, .55 1SG2993
ATOM 2993 C LEU 384 63 .134 27 .562 27 .698 1. .00 44 .55 1SG2994
ATOM 2994 O LEU 384 62 .439 27 .175 26 .761 1. .00 44 .55 1SG2995
ATOM 2995 N ALA 385 63, .275 26 .870 28, .842 1. .00 39, .52 1SG2996
ATOM 2996 CA ALA 385 62 .546 25 .669 29 .110 1. .00 39 .52 1SG2997
ATOM 2997 CB ALA 385 63 .353 24, .392 28, .834 1. .00 39 .52 1SG2998
ATOM 2998 C ALA 385 62 .271 25, .717 30 .576 1. .00 39 .52 1SG2999
ATOM 2999 O ALA 385 63 .065 26 .269 31 .333 1. .00 39 .52 1SG3000
ATOM 3000 N LEU 386 61. .129 25, .155 31, .017 1, .00 37, .13 1SG3001
ATOM 3001 CA LEU 386 60 .807 25 .199 32 .414 1. .00 37 .13 1SG3002
ATOM 3002 CB LEU 386 59 .332 25, .575 32, .659 1. .00 37 .13 1SG3003
ATOM 3003 CG LEU 386 58. .923 25, .650 34, .140 1. .00 37, .13 1SG3004
ATOM 3004 CD2 LEU 386 57 .394 25 .746 34 .288 1. .00 37 .13 1SG3005
ATOM 3005 CDl LEU 386 59. .659 26, .787 34, .866 1. .00 37, .13 1SG3006
ATOM 3006 C LEU 386 61, .034 23 .828 32 .976 1. .00 37, .13 1SG3007
ATOM 3007 O LEU 386 60. .317 22, .889 32 .641 1. .00 37, .13 1SG3008
ATOM 3008 N PRO 387 62, .092 23, .673 33, .737 1. .00 34, .69 1SG3009
ATOM 3009 CA PRO 387 62, .364 22, .420 34 .400 1. .00 34, .69 1SG3010
ATOM 3010 CD PRO 387 63, .316 24, .388 33, .428 1. .00 34, .69 1SG3011
ATOM 3011 CB PRO 387 63. .870 22. .400 34, .685 1. ,00 34. .69 1SG3012
ATOM 3012 CG PRO 387 64. .336 23, .846 34, .438 1. .00 34, .69 1SG3013
ATOM 3013 C PRO 387 61. .520 22. .095 35, .599 1. .00 34. .69 1SG3014
ATOM 3014 O PRO 387 61. .180 20. .926 35 .778 1. .00 34, .69 1SG3015
ATOM 3015 N GLU 388 61. .184 23. .095 36, .440 1. .00 37, .19 1SG3016
ATOM 3016 CA GLU 388 60. .399 22. .824 37, .613 1. .00 37. .19 1SG3017
ATOM 3017 CB GLU 388 61, .132 21, .977 38, .666 1. .00 37. .19 1SG3018
ATOM 3018 CG GLU 388 60. .247 21, .577 39, .848 1. .00 37. .19 1SG3019
ATOM 3019 CD GLU 388 61. .093 20. .749 40, .803 1. .00 37. ,19 1SG3020
ATOM 3020 OEl GLU 388 62. .345 20. .856 40, .720 1. .00 37. .19 1SG3021
ATOM 3021 OE2 GLU 388 60. .501 20. .002 41. .628 1. .00 37. ,19 1SG3022
ATOM 3022 C GLU 388 60. .099 24. .138 38. .249 1. .00 37. .19 1SG3023
ATOM 3023 O GLU 388 60. .899 25. .068 38, .161 1. ,00 37. .19 1SG3024
ATOM 3024 N SER 389 58. ,928 24. ,260 38. .907 1. 00 41. .85 1SG3025
ATOM 3025 CA SER 389 58. .623 25. .514 39. .526 1. .00 41. .85 1SG3026 ATOM 3026 CB SER 389 57..698 26..403 38..677 1..00 41..85 1SG3027
ATOM 3027 OG SER 389 57. .438 27. .626 39. .350 1. ,00 41. .85 1SG3028
ATOM 3028 C SER 389 57, .921 25. .261 40. .821 1. .00 41. .85 1SG3029
ATOM 3029 O SER 389 57, .015 24. .435 40. .900 1. .00 41. .85 1SG3030
ATOM 3030 N ASN 390 58. .359 25. .962 41. .884 1. ,00 47. .41 1SG3031
ATOM 3031 CA ASN 390 57. .723 25. .886 43. .166 1. ,00 47. .41 1SG3032
ATOM 3032 CB ASN 390 58. .578 26. .475 44 .301 1. .00 47. .41 1SG3033
ATOM 3033 CG ASN 390 59. .761 25. .540 44. .503 1. .00 47. .41 1SG3034
ATOM 3034 ODl ASN 390 59. .970 24, .610 43, .724 1. .00 47. .41 1SG3035
ATOM 3035 ND2 ASN 390 60, .549 25, .777 45, .585 1. .00 47, .41 1SG3036
ATOM 3036 C ASN 390 56 .443 26. .665 43 .093 1. .00 47, .41 1SG3037
ATOM 3037 O ASN 390 55, .459 26. .342 43 , .755 1. .00 47. .41 1SG3038
ATOM 3038 N ARG 391 56, .463 27, .740 42, .282 1. .00 55, .02 1SG3039
ATOM 3039 CA ARG 391 55, .398 28, .686 42 .091 1. .00 55, .02 1SG3040
ATOM 3040 CB ARG 391 55, .837 29, .859 41, .196 1. ,00 55, .02 1SG3041
ATOM 3041 CG ARG 391 54, .712 30, .808 40, .779 1. .00 55, .02 1SG3042
ATOM 3042 CD ARG 391 54, .173 30, .534 39 .369 1. .00 55, .02 1SG3043
ATOM 3043 NE ARG 391 52 .850 29 .862 39 .505 1. .00 55 .02 1SG3044
ATOM 3044 CZ ARG 391 51, .997 29, .797 38 .442 1. .00 55, .02 1SG3045
ATOM 3045 NHl ARG 391 52 .357 30, .339 37 .242 1. .00 55, .02 1SG3046
ATOM 3046 NH2 ARG 391 50 .782 29 .189 38 .579 1, .00 55 .02 1SG3047
ATOM 3047 C ARG 391 54, .191 28, .077 41, .459 1. .00 55, .02 1SG3048
ATOM 3048 O ARG 391 53, .087 28, .504 41 .775 1. .00 55, .02 1SG3049
ATOM 3049 N SER 392 54 .371 27, .138 40 .509 1, .00 54 .60 1SG3050
ATOM 3050 CA SER 392 53 .339 26 .432 39 .787 1. .00 54 .60 1SG3051
ATOM 3051 CB SER 392 51, .879 26, .906 39, .945 1. .00 54, .60 1SG3052
ATOM 3052 OG SER 392 51 .408 26 .619 41 .254 1. .00 54 .60 1SG3053
ATOM 3053 C SER 392 53 .682 26 .600 38 .351 1. .00 54 .60 1SG3054
ATOM 3054 O SER 392 54. .647 27. .286 38 .019 1. .00 54. .60 1SG3055
ATOM 3055 N ASN 393 52 .896 25. .978 37 .456 1. .00 52 .91 1SG3056
ATOM 3056 CA ASN 393 53 .202 26 .081 36 .061 1. .00 52 .91 1SG3057
ATOM 3057 CB ASN 393 52 .468 25 .043 35 .195 1. .00 52 .91 1SG3058
ATOM 3058 CG ASN 393 50, .971 25, .282 35, .334 1. .00 52, .91 1SG3059
ATOM 3059 ODl ASN 393 50 .434 25, .313 36 .440 1. .00 52 .91 1SG3060
ATOM 3060 ND2 ASN 393 50 .276 25 .461 34 .179 1. .00 52 .91 1SG3061
ATOM 3061 C ASN 393 52, .814 27, .443 35, .582 1. .00 52 .91 1SG3062
ATOM 3062 O ASN 393 51 .757 27 .967 35 .930 1, .00 52 .91 1SG3063
ATOM 3063 N ILE 394 53 .698 28 .055 34 .770 1. .00 49, .59 1SG3064
ATOM 3064 CA ILE 394 53 .463 29 .351 34 .207 1, .00 49 .59 1SG3065
ATOM 3065 CB ILE 394 54, .114 30, .465 34, .974 1. .00 49, .59 1SG3066
ATOM 3066 CG2 ILE 394 55 .637 30 .288 34 .862 1. .00 49, .59 1SG3067
ATOM 3067 CGI ILE 394 53 .604 31 .828 34 .475 1. .00 49 .59 1SG3068
ATOM 3068 CDl ILE 394 52. .126 32, .071 34, .776 1. .00 49, .59 1SG3069
ATOM 3069 C ILE 394 54, .050 29, .359 32, .833 1. .00 49, .59 1SG3070
ATOM 3070 O ILE 394 54 .799 28 .459 32 .454 1. .00 49, .59 1SG3071
ATOM 3071 N GLU 395 53 .704 30, .385 32 , .033 1. .00 45, .36 1SG3072
ATOM 3072 CA GLU 395 54, .249 30, .440 30, .710 1. .00 45, .36 1SG3073
ATOM 3073 CB GLU 395 53 .593 31. .509 29, .818 1. .00 45, .36 1SG3074
ATOM 3074 CG GLU 395 52 .142 31 .201 29 .433 1. .00 45, .36 1SG3075
ATOM 3075 CD GLU 395 51, .246 31. .460 30, .637 1. ,00 45, .36 1SG3076
ATOM 3076 OEl GLU 395 51, .142 30, .556 31, .508 1. .00 45. .36 1SG3077
ATOM 3077 OE2 GLU 395 50 .648 32, .568 30, .698 1. .00 45. .36 1SG3078
ATOM 3078 C GLU 395 55. .701 30, .780 30, .848 1. .00 45. .36 1SG3079
ATOM 3079 O GLU 395 56. .072 31. .825 31, .379 1. .00 45. .36 1SG3080
ATOM 3080 N VAL 396 56. .560 29, .882 30, .340 1. .00 45. .84 1SG3081
ATOM 3081 CA VAL 396 57 .989 30, .009 30, .390 1. .00 45, .84 1SG3082
ATOM 3082 CB VAL 396 58, .699 28. .810 29. .834 1. .00 45. .84 1SG3083 ATOM 3083 CGI VAL 396 58..334 28..664 28..347 1.00 45.,84 1SG3084
ATOM 3084 CG2 VAL 396 60. .206 28. .980 30. ,088 1. .00 45. ,84 1SG3085
ATOM 3085 C VAL 396 58. .392 31, .198 29. .578 1. .00 45. .84 1SG3086
ATOM 3086 O VAL 396 59. .462 31. .768 29. .782 1. .00 45. .84 1SG3087
ATOM 3087 N LEU 397 57. .541 31. .561 28. .603 1. .00 45, .79 1SG3088
ATOM 3088 CA LEU 397 57. .755 32. .615 27, .652 1. .00 45. .79 1SG3089
ATOM 3089 CB LEU 397 56. .634 32. .689 26. .600 1. .00 45. .79 1SG3090
ATOM 3090 CG LEU 397 56. .517 31. .422 25, .730 1, .00 45, .79 • 1SG3091
ATOM 3091 CD2 LEU 397 55. .571 31, .648 24. .539 1. .00 45. .79 1SG3092
ATOM 3092 CDl LEU 397 56. .124 30. .198 26. .571 1. .00 45. .79 1SG3093
ATOM 3093 C LEU 397 57, .833 33, .963 28. .314 1. .00 45. .79 1SG3094
ATOM 3094 O LEU 397 58. .504 34. .857 27. .802 1. .00 45. .79 1SG3095
ATOM 3095 N ARG 398 57. .134 34. .171 29, .445 1. .00 46, .32 1SG3096
ATOM 3096 CA ARG 398 57. .073 35. .480 30. .042 1. .00 46, .32 1SG3097
ATOM 3097 CB ARG 398 56. .047 35. .586 31. .185 1. .00 46. .32 1SG3098
ATOM 3098 CG ARG 398 55. .625 37. .034 31, .451 1, .00 46. .32 1SG3099
ATOM 3099 CD ARG 398 54. .224 37. .175 32 , .055 1. .00 46, .32 1SG3100
ATOM 3100 NE ARG 398 53. .241 36. .717 31. .034 1. .00 46, .32 1SG3101
ATOM 3101 CZ ARG 398 51, .914 36, .652 31. .349 1. .00 46, .32 1SG3102
ATOM 3102 NHl ARG 398 51. .491 37, .000 32. .599 1. .00 46, .32 1SG3103
ATOM 3103 NH2 ARG 398 51. .010 36, .240 30. .413 1. .00 46 .32 1SG3104
ATOM 3104 C ARG 398 58. .431 35, .953 30, .494 1. .00 46. .32 1SG3105
ATOM 3105 O ARG 398 58. .676 37. .157 30. .562 1. .00 46, .32 1SG3106
ATOM 3106 N PHE 399 59. .330 35. .013 30. .845 1. .00 48 .03 1SG3107
ATOM 3107 CA PHE 399 60, .682 35. .222 31. .305 1. .00 48, .03 1SG3108
ATOM 3108 CB PHE 399 61. .322 33, .943 31. .870 1, .00 48 .03 1SG3109
ATOM 3109 CG PHE 399 60. .591 33, .584 33 , .118 1, .00 48 .03 1SG3110
ATOM 3110 CDl PHE 399 59. .413 32, .876 33. .061 1, .00 48, .03 1SG3111
ATOM 3111 CD2 PHE 399 61, .086 33 .957 34. .346 1, .00 48 .03 1SG3112
ATOM 3112 CE1 PHE 399 58 .739 32 .545 34 , .213 1 .00 48 .03 1SG3113
ATOM 3113 CE2 PHE 399 60, .416 33, .628 35. .500 1. .00 48, .03 1SG3114
ATOM 3114 CZ PHE 399 59, .240 32, .921 35. .436 1, .00 48 .03 1SG3115
ATOM 3115 C PHE 399 61, .572 35, .715 30. .199 1. .00 48, .03 1SG3116
ATOM 3116 O PHE 399 62 .632 36 .280 30. .458 1. .00 48 .03 1SG3117
ATOM 3117 N GLU 400 61, .203 35, .474 28. .930 1, .00 49 .32 1SG3118
ATOM 3118 CA GLU 400 62, .081 35, .757 27. .828 1, .00 49, .32 1SG3119
ATOM 3119 CB GLU 400 61, .414 35, .505 26, .468 1, .00 49 .32 1SG3120
ATOM 3120 CG GLU 400 61, .097 34, .027 26 .231 1, .00 49, .32 1SG3121
ATOM 3121 CD GLU 400 60, .447 33, .898 24. .865 1. .00 49, .32 1SG3122
ATOM 3122 OEl GLU 400 60, .315 34, .944 24. .176 1. .00 49, .32 1SG3123
ATOM 3123 OE2 GLU 400 60, .075 32, .754 24. .491 1. .00 49, .32 1SG3124
ATOM 3124 C GLU 400 62 .568 37 .176 27. .846 1, .00 49, .32 1SG3125
ATOM 3125 O GLU 400 63, .744 37, .416 27. .579 1. .00 49, .32 1SG3126
ATOM 3126 N ASN 401 61. .703 38, .159 28. .153 1. .00 51. .71 1SG3127
ATOM 3127 CA ASN 401 62. .148 39, .525 28. .138 1. .00 51, .71 1SG3128
ATOM 3128 CB ASN 401 61. .000 40. .522 28. .404 1, .00 51, .71 1SG3129
ATOM 3129 CG ASN 401 60. .339 40. .201 29. .740 1, .00 51, .71 1SG3130
ATOM 3130 ODl ASN 401 60. .384 39. .073 30. .229 1. .00 51, .71 1SG3131
ATOM 3131 ND2 ASN 401 59. .678 41. .225 30. .341 1. .00 51. .71 1SG3132
ATOM 3132 C ASN 401 63. .233 39. .734 29. .153 1, .00 51, .71 1SG3133
ATOM 3133 O ASN 401 64. .252 40 .356 28. .856 1. .00 51, .71 1SG3134
ATOM 3134 N ILE 402 63. .062 39. .227 30. .387 1. .00 53. .13 1SG3135
ATOM 3135 CA ILE 402 64, .093 39, .437 31. .358 1. .00 53. .13 1SG3136
ATOM 3136 CB ILE 402 63. .712 39. .134 32. .773 1. ,00 53. .13 1SG3137
ATOM 3137 CG2 ILE 402 62. .583 40. .095 33. .152 1. .00 53. .13 1SG3138
ATOM 3138 CGI ILE 402 63. .356 37. .669 32. ,990 1. .00 53. .13 1SG3139
ATOM 3139 CDl ILE 402 63. .241 37. .360 34. ,477 1. .00 53. .13 1SG3140 ATOM 3140 C ILE 402 65.,330 38..683 30.,973 1..00 53..13 1SG3141
ATOM 3141 O >ILE 402 66. .439 39. .190 31. ,127 1. .00 53. ,13 1SG3142
ATOM 3142 N LEU 403 65. .179 37. .450 30. .455 1. .00 51. ,84 1SG3143
ATOM 3143 CA LEU 403 66. .317 36. ,660 30. .068 1. .00 51. ,84 1SG3144
ATOM 3144 CB LEU 403 65. .955 35. .241 29. .585 1. .00 51. .84 1SG3145
ATOM 3145 CG LEU 403 65. .662 34. .233 30. .717 1. .00 51. .84 1SG3146
ATOM 3146 CD2 LEU 403 64, .526 34. .699 31. .640 1. .00 51. .84 1SG3147
ATOM 3147 CDl LEU 403 66. .945 33. .899 31. .496 1. ,00 51. .84 1SG3148
ATOM 3148 C LEU 403 67. .064 37. ,355 28. .973 1. ,00 51. .84 1SG3149
ATOM 3149 O LEU 403 68. .290 37. ,266 28. .902 1. ,00 51. .84 1SG3150
ATOM 3150 N SER 404 66. .348 38. .046 28. .069 1. .00 51. .23 1SG3151
ATOM 3151 CA SER 404 67. .007 38. .704 26. .979 1. .00 51. .23 1SG3152
ATOM 3152 CB SER 404 66, .038 39. .332 25. .962 1. .00 51. .23 1SG3153
ATOM 3153 OG SER 404 65, .373 40, .447 26. .536 1. .00 51. .23 1SG3154
ATOM 3154 C SER 404 67, .876 39, .803 27, .503 1. .00 51. .23 1SG3155
ATOM 3155 O SER 404 68. .920 40. .082 26. .923 1. ,00 51. .23 1SG3156
ATOM 3156 N SER 405 67. .445 ' 40. .507 28. .565 1. ,00 50. .40 1SG3157
ATOM 3157 CA SER 405 68. .250 41. .566 29, .117 1. .00 50. .40 1SG3158
ATOM 3158 CB SER 405 67, .440 42. .521 30. .010 1. .00 50. .40 1SG3159
ATOM 3159 OG SER 405 68, .289 43 , .536 30. .524 1, .00 50. .40 1SG3160
ATOM 3160 C SER 405 69, .378 41, .040 29, .962 1. .00 50. .40 1SG3161
ATOM 3161 O SER 405 70, .531 41, .448 29, .810 1, .00 50. .40 1SG3162
ATOM 3162 N ILE 406 69. .068 40. .099 30. .879 1. .00 55. .36 1SG3163
ATOM 3163 CA ILE 406 70, .035 39. .689 31. .860 1. .00 55. .36 1SG3164
ATOM 3164 CB ILE 406 69, .506 38. .586 32. .736 1. .00 55. .36 1SG3165
ATOM 3165 CG2 ILE 406 70, .612 38, .226 33. .743 1. .00 55. .36 1SG3166
ATOM 3166 CGI ILE 406 68, .161 38. .972 33, .384 1. .00 55, .36 1SG3167
ATOM 3167 CDl ILE 406 68, .216 40. .201 34, .288 1, .00 55, .36 1SG3168
ATOM 3168 C ILE 406 71 .239 39. .122 31, .183 1. .00 55 .36 1SG3169
ATOM 3169 O ILE 406 72 .363 39. .553 31, .448 1, .00 55, .36 1SG3170
ATOM 3170 N LEU 407 71, .045 38. .150 30, .269 1. .00 62. .52 1SG3171
ATOM 3171 CA LEU 407 72 , .227 37. .553 29, .728 1. .00 62, .52 1SG3172
ATOM 3172 CB LEU 407 72 , .027 36. .265 28, .910 1, .00 62, .52 1SG3173
ATOM 3173 CG LEU 407 71, .815 35, .041 29, .819 1. .00 62, .52 1SG3174
ATOM 3174 CD2 LEU 407 72. .342 33, .753 29, .168 1. .00 62, .52 1SG3175
ATOM 3175 CDl LEU 407 70. .385 34, .970 30, .379 1, .00 62 .52 1SG3176
ATOM 3176 C LEU 407 73 .082 38, .492 28, .924 1. .00 62 .52 1SG3177
ATOM 3177 O LEU 407 74 , .283 38. .601 29. .165 1. .00 62 , .52 1SG3178
ATOM 3178 N HIS 408 72. .505 39. .231 27. .967 1. .00 70, .77 1SG3179
ATOM 3179 CA HIS 408 73. .314 40. .062 27, .116 1. .00 70, .77 1SG3180
ATOM 3180 NDl HIS 408 72. .521 39. .570 23 , .818 1, .00 70, .77 1SG3181
ATOM 3181 CG HIS 408 71, .910 39. .875 25, .014 1, .00 70, .77 1SG3182
ATOM 3182 CB HIS 408 72, .488 40. .797 26, .046 1, .00 70, .77 1SG3183
ATOM 3183 NE2 HIS 408 70, .602 38, .446 23, .858 1. .00 70, .77 1SG3184
ATOM 3184 CD2 HIS 408 70, .741 39, .180 25, .022 1. .00 70, .77 1SG3185
ATOM 3185 CE1 HIS 408 71, .695 38. .712 23. .166 1. .00 70. .77 1SG3186
ATOM 3186 C HIS 408 74 , .005 41. .100 27, .931 1. .00 70. .77 1SG3187
ATOM 3187 O HIS 408 75, .178 41. .390 27. .706 1. .00 70. .77 1SG3188
ATOM 3188 N PHE 409 73, .296 41. .721 28, .887 1. .00 80. .53 1SG3189
ATOM 3189 CA PHE 409 73, .985 42. .681 29, .687 1. .00 80, .53 1SG3190
ATOM 3190 CB PHE 409 73 , .236 44, .019 29, .823 1, .00 80, .53 1SG3191
ATOM 3191 CG PHE 409 74, .116 44, .959 30, .573 1, .00 80, .53 1SG3192
ATOM 3192 CDl PHE 409 74. .177 44. .926 31. .948 1. .00 80. .53 1SG3193
ATOM 3193 CD2 PHE 409 74 , .880 45. .879 29. .892 1. .00 80. .53 1SG3194
ATOM 3194 CE1 PHE 409 74 , .993 45. ,798 32. .631 1. .00 80, .53 1SG3195
ATOM 3195 CE2 PHE 409 75, .697 46. .753 30. .569 1. .00 80, .53 1SG3196
ATOM 3196 CZ PHE 409 75, .754 46. .711 31. .941 1. .00 80, .53 1SG3197 ATOM 3197 C PHE 409 74..076 42..082 31..048 1.00 80..53 1SG3198
ATOM 3198 O PHE 409 73. .145 42, .130 31. .831 1. .00 80. .53 1SG3199
ATOM 3199 N GLY 410 75. .228 41. .543 31. .424 1. 00 80. .63 1SG3200
ATOM 3200 CA GLY 410 75. .346 40, .960 32. .723 1. ,00 80. .63 1SG3201
ATOM 3201 C GLY 410 76. .081 39, .662 32. .593 1. ,00 80. .63 1SG3202
ATOM 3202 O GLY 410 77. .180 39. .552 33. .131 1. ,00 80. .63 1SG3203
ATOM 3203 N VAL 411 75. .519 38. .634 31. .921 1. .00 76. .51 1SG3204
ATOM 3204 CA VAL 411 76. .285 37. .420 31. .818 1. .00 76, .51 1SG3205
ATOM 3205 CB VAL 411 75. .476 36. .161 31. .649 1. .00 76. .51 1SG3206
ATOM 3206 CGI VAL 411 74, .542 36. .022 32. .858 1. .00 76. .51 1SG3207
ATOM 3207 CG2 VAL 411 74, .751 36. .167 30, .309 1. .00 76. .51 1SG3208
ATOM 3208 C VAL 411 77. .347 37, .472 30. .753 1. .00 76. .51 1SG3209
ATOM 3209 O VAL 411 78. .495 37, .112 31. .001 1. .00 76. .51 1SG3210
ATOM 3210 N LEU 412 77, .009 37, .941 29. .535 1. .00 66. .38 1SG3211
ATOM 3211 CA LEU 412 77, .955 37, .895 28. .447 1. .00 66. .38 1SG3212
ATOM 3212 CB LEU 412 77, .434 38, .405 27, .099 1. .00 66, .38 1SG3213
ATOM 3213 CG LEU 412 76, .556 37, .430 26, .307 1. .00 66 .38 1SG3214
ATOM 3214 CD2 LEU 412 76. .519 37, .868 24. .837 1. .00 66, .38 1SG3215
ATOM 3215 CDl LEU 412 75, .175 37, .217 26. .948 1. .00 66, .38 1SG3216
ATOM 3216 C LEU 412 79, .165 38 .729 28, .715 1. .00 66 .38 1SG3217
ATOM 3217 O LEU 412 80, .273 38, .299 28, .395 1. .00 66 .38 1SG3218
ATOM 3218 N PRO 413 79, .031 39 .899 29, .272 1. .00 52 .02 1SG3219
ATOM 3219 CA PRO 413 80 .199 40 .717 29, .423 1, .00 52 .02 1SG3220
ATOM 3220 CD PRO 413 77, .825 40, .698 29, .120 1. .00 52 .02 1SG3221
ATOM 3221 CB PRO 413 79, .685 42 .074 29, .895 1, .00 52 .02 1SG3222
ATOM 3222 CG PRO 413 78 .286 42 .161 29 .253 1, .00 52 .02 1SG3223
ATOM 3223 C PRO 413 81, .268 40, .104 30, .271 1. .00 52 .02 1SG3224
ATOM 3224 O PRO 413 82 .446 40 .319 29, .984 1. .00 52 .02 1SG3225
ATOM 3225 N LEU 414 80 .895 39 .349 31 .318 1. .00 41 .13 1SG3226
ATOM 3226 CA LEU 414 81. .881 38, .750 32. .173 1. .00 41, .13 1SG3227
ATOM 3227 CB LEU 414 81 .222 38 .080 33. .402 1, .00 41 .13 1SG3228
ATOM 3228 CG LEU 414 82 .153 37 .521 34 .506 1. .00 41 .13 1SG3229
ATOM 3229 CD2 LEU 414 83. .177 36, .496 33. .990 1. .00 41 .13 1SG3230
ATOM 3230 CDl LEU 414 81 .316 36 .932 35 .653 1. .00 41 .13 1SG3231
ATOM 3231 C LEU 414 82 .626 37 .718 31 .383 1. .00 41 .13 1SG3232
ATOM 3232 O LEU 414 83. .852 37, .633 31, .455 1. .00 41, .13 1SG3233
ATOM 3233 N ALA 415 81 .891 36 .901 30, .605 1. .00 34 .58 1SG3234
ATOM 3234 CA ALA 415 82 .484 35 .822 29 .864 1. .00 34 .58 1SG3235
ATOM 3235 CB ALA 415 81. .438 34, .984 29, .109 1. .00 34 .58 1SG3236
ATOM 3236 C ALA 415 83. .442 36 .350 28 .844 1, .00 34 .58 1SG3237
ATOM 3237 O ALA 415 84 .550 35 .837 28 .703 1. .00 34 .58 1SG3238
ATOM 3238 N ASN 416 83, .049 37, .414 28, .123 1. .00 33, .64 1SG3239
ATOM 3239 CA ASN 416 83 .858 37 .941 27, .063 1. .00 33 .64 1SG3240
ATOM 3240 CB ASN 416 83 .190 39 .118 26 .330 1, .00 33 .64 1SG3241
ATOM 3241 CG ASN 416 82, .018 38, .559 25, .530 1. .00 33, .64 1SG3242
ATOM 3242 ODl ASN 416 82, .097 37 .459 24, .984 1. .00 33, .64 1SG3243
ATOM 3243 ND2 ASN 416 80 .900 39 .329 25, .459 1. .00 33 .64 1SG3244
ATOM 3244 C ASN 416 85, .153 38, .413 27, .634 1. .00 33, .64 1SG3245
ATOM 3245 O ASN 416 86, .178 38, .381 26, .956 1. .00 33, .64 1SG3246
ATOM 3246 N ALA 417 85 .144 38 .878 28 .896 1. .00 36 .80 1SG3247
ATOM 3247 CA ALA 417 86, .353 39, .390 29. .474 1. .00 36, .80 1SG3248
ATOM 3248 CB ALA 417 86, .163 39, .880 30. .920 1. .00 36 .80 1SG3249
ATOM 3249 C ALA 417 87 .401 38 .316 29 .498 1. .00 36 .80 1SG3250
ATOM 3250 O ALA 417 88, .557 38, .581 29. .176 1. .00 36, .80 1SG3251
ATOM 3251 N LYS 418 87, .037 37. .078 29. .892 1. .00 41, .91 1SG3252
ATOM 3252 CA LYS 418 87, .996 36. .008 29. .934 1. .00 41 .91 1SG3253
ATOM 3253 CB LYS 418 87, .431 34, .707 30. .528 1. .00 41, .91 1SG3254 ATOM 3254 CG LYS 418 87..451 34..674 32..055 1..00 41..91 1SG3255
ATOM 3255 CD LYS 418 88. .872 34. .731 32. .620 1. .00 41. .91 1SG3256
ATOM 3256 CE LYS 418 89. .748 33. .554 32. .179 1. .00 41. .91 1SG3257
ATOM 3257 NZ LYS 418 91. .146 33 .759 32. .621 1, .00 41. .91 1SG3258
ATOM 3258 C LYS 418 88. .459 35. .687 28. .550 1. .00 41. .91 1SG3259
ATOM 3259 O LYS 418 89. .654 35. .527 28, .308 1. .00 41. .91 1SG3260
ATOM 3260 N LEU 419 87. .519 35. .591 27, .593 1. .00 43. .77 1SG3261
ATOM 3261 CA LEU 419 87. .904 35, .235 26, .259 1. .00 43. .77 1SG3262
ATOM 3262 CB LEU 419 86. .739 35, .033 25 .269 1. .00 43. .77 1SG3263
ATOM 3263 CG LEU 419 85. .879 33, .784 25, .546 1. .00 43. .77 1SG3264
ATOM 3264 CD2 LEU 419 85. .207 33, .275 24, .265 1. .00 43. .77 1SG3265
ATOM 3265 CDl LEU 419 84. .898 33 .995 26, .707 1. .00 43. .77 1SG3266
ATOM 3266 C LEU 419 88. .795 36 .294 25 .702 1. .00 43. .77 1SG3267
ATOM 3267 O LEU 419 89, .744 35, .993 24, .981 1. .00 43. .77 1SG3268
ATOM 3268 N GLN 420 88, .505 37 .571 26, .002 1. .00 43. .98 1SG3269
ATOM 3269 CA GLN 420 89 .341 38 .618 25 .499 1. .00 43, .98 1SG3270
ATOM 3270 CB GLN 420 88 .781 40 .035 25 .656 1. .00 43, .98 1SG3271
ATOM 3271 CG GLN 420 88. .632 40. .523 27', .088 1. .00 43. .98 1SG3272
ATOM 3272 CD GLN 420 88. .323 41. .999 26, .949 1. .00 43. .98 1SG3273
ATOM 3273 OEl GLN 420 89. .125 42. .750 26, .396 1. .00 43. .98 1SG3274
ATOM 3274 NE2 GLN 420 87, .126 42 .425 27 .431 1. .00 43. .98 1SG3275
ATOM 3275 C GLN 420 90, .679 38. .541 26, .164 1. .00 43. .98 1SG3276
ATOM 3276 O GLN 420 91, .687 38. .930 25, .577 1. .00 43. .98 1SG3277
ATOM 3277 N GLN 421 90 .729 38. .063 27 .423 1. .00 41. .54 1SG3278
ATOM 3278 CA GLN 421 91 .993 37 .955 28 .089 1. .00 41, .54 1SG3279
ATOM 3279 CB GLN 421 91. .870 37, .320 29. .485 1, .00 41 .54 1SG3280
ATOM 3280 CG GLN 421 93 .198 37 .201 30 .234 1. .00 41, .54 1SG3281
ATOM 3281 CD GLN 421 93 .548 38 .573 30 .793 1, .00 41, .54 1SG3282
ATOM 3282 OEl GLN 421 93 .991 38, .690 31, .934 1. .00 41, .54 1SG3283
ATOM 3283 NE2 GLN 421 93. .351 39. .639 29 .972 1, .00 41, .54 1SG3284
ATOM 3284 C GLN 421 92. .799 37. .038 27, .233 1. .00 41, .54 1SG3285
ATOM 3285 O GLN 421 93. .970 37, .291 26, .957 1. .00 41, .54 1SG3286
ATOM 3286 N GLY 422 92 .162 35, .949 26 .764 1. .00 39, .45 1SG3287
ATOM 3287 CA GLY 422 92, .795 35 .078 25 .824 1. .00 39, .45 1SG3288
ATOM 3288 C GLY 422 93, .568 34, .014 26 .521 1, .00 39, .45 1SG3289
ATOM 3289 O GLY 422 93 .585 33, .918 27 .748 1. .00 39, .45 1SG3290
ATOM 3290 N PHE 423 94 .221 33, .166 25 .701 1. .00 40, .77 1SG3291
ATOM 3291 CA PHE 423 95 .019 32 .094 26 .201 1, .00 40 .77 1SG3292
ATOM 3292 CB PHE 423 94, .455 30, .699 25 .871 1, .00 40, .77 1SG3293
ATOM 3293 CG PHE 423 93, .125 30. .587 26. .543 1. .00 40. .77 1SG3294
ATOM 3294 CDl PHE 423 93 , .035 30. .514 27, .913 1. .00 40. .77 1SG3295
ATOM 3295 CD2 PHE 423 91, .966 30. .538 25, .803 1. .00 40. .77 1SG3296
ATOM 3296 CE1 PHE 423 91, .810 30. .406 28. .526 1. .00 40. .77 1SG3297
ATOM 3297 CE2 PHE 423 90, .735 30. .429 26, .405 1. .00 40. .77 1SG3298
ATOM 3298 CZ PHE 423 90, .661 30. .368 27, .773 1. .00 40. .77 1SG3299
ATOM 3299 C PHE 423 96, .362 32, .238 25, .558 1, .00 40, .77 1SG3300
ATOM 3300 O PHE 423 96. .480 32. .736 24. .439 1. .00 40, .77 1SG3301
ATOM 3301 N PRO 424 97, .386 31. .837 26, .258 1. .00 42. .22 1SG3302
ATOM 3302 CA PRO 424 98, .715 31. .981 25, .730 1. .00 42. .22 1SG3303
ATOM 3303 CD PRO 424 97, .363 31. .960 27 .708 1. .00 42. .22 1SG3304
ATOM 3304 CB PRO 424 99, .655 31, .796 26 .921 1, .00 42, .22 1SG3305
ATOM 3305 CG PRO 424 98. .811 32. ,264 28. .123 1. ,00 42. .22 1SG3306
ATOM 3306 C PRO 424 98. .995 31. .069 24, .578 1. ,00 42. ,22 1SG3307
ATOM 3307 O PRO 424 98. .521 29. ,933 24, .583 1. ,00 42. ,22 1SG3308
ATOM 3308 N LEU 425 99. .776 31. .547 23, .584 1. .00 45. .11 1SG3309
ATOM 3309 CA LEU 425 100. ,128 30. .748 22, .442 1. .00 45. .11 1SG3310
ATOM 3310 CB LEU 425 100. .146 31. .511 21, .105 1. .00 45. .11 1SG3311 ATOM 3311 CG LEU 425 98..745 31..767 20..513 1..00 45..11 1SG3312
ATOM 3312 CD2 LEU 425 98. .845 32. .361 19. .100 1. .00 45. .11 1SG3313
ATOM 3313 CDl LEU 425 97. .859 32. .601 21. .449 1. .00 45. .11 1SG3314
ATOM 3314 C LEU 425 101. .489 30, .177 22. .680 1. .00 45. .11 1SG3315
ATOM 3315 O LEU 425 102. .266 30. .703 23. .477 1. .00 45. .11 1SG3316
ATOM 3316 N SER 426 101. .808 29. .059 21. .995 1. .00 47. .78 1SG3317
ATOM 3317 CA SER 426 103. .073 28. .433 22. .242 1. .00 47, .78 1SG3318
ATOM 3318 CB SER 426 103. .091 26. .940 21. .866 1. .00 47, .78 1SG3319
ATOM 3319 OG SER 426 102. .824 26, .778 20. .481 1. .00 47, .78 1SG3320
ATOM 3320 C SER 426 104. .133 29, .137 21. .460 1. .00 47, .78 1SG3321
ATOM 3321 O SER 426 104. .537 28 .703 20, .382 1, .00 47, .78 1SG3322
ATOM 3322 N ASN 427 104. .653 30, .241 22. .030 1. .00 50. .46 1SG3323
ATOM 3323 CA ASN 427 105. .678 30. .985 21. .359 1. .00 50. .46 1SG3324
ATOM 3324 CB ASN 427 105. .283 32, .443 21. .058 1. .00 50. .46 1SG3325
ATOM 3325 CG ASN 427 105. .094 33, .181 22. .378 1. .00 50. .46 1SG3326
ATOM 3326 ODl ASN 427 104, .376 32, .732 23, .270 1. .00 50. .46 1SG3327
ATOM 3327 ND2 ASN 427 105, .764 34 .358 22, .508 1. .00 50, .46 1SG3328
ATOM 3328 C ASN 427 106. .876 31. .029 22. .252 1. .00 50, .46 1SG3329
ATOM 3329 O ASN 427 106. .781 31. .160 23. .471 1. .00 50, .46 1SG3330
ATOM 3330 N PRO 428 108, .009 30, .941 21, .620 1, .00 53, .03 1SG3331
ATOM 3331 CA PRO 428 109. .303 30. .960 22, .250 1. .00 53, .03 1SG3332
ATOM 3332 CD PRO 428 108. .091 31. .117 20, .180 1. .00 53 .03 1SG3333
ATOM 3333 CB PRO 428 110. .301 30 .787 21, .108 1, .00 53 .03 1SG3334
ATOM 3334 CG PRO 428 109, .574 31 .407 19, .901 1 .00 53 .03 1SG3335
ATOM 3335 C PRO 428 109, .468 32. .298 22 , .902 1. .00 53, .03 1SG3336
ATOM 3336 O PRO 428 108, .572 33, .127 22, .764 1, .00 53, .03 1SG3337
ATOM 3337 N HIS 429 110, .601 32, .496 23, .614 1, .00 54, .41 1SG3338
ATOM 3338 CA HIS 429 110, .990 33, .643 24, .398 1, .00 54, .41 1SG3339
ATOM 3339 NDl HIS 429 114, .126 34, .759 26, .336 1, .00 54 .41 1SG3340
ATOM 3340 CG HIS 429 112, .868 34 .655 25, .785 1, .00 54 .41 1SG3341
ATOM 3341 CB HIS 429 112 , .489 33, .638 24, .748 1. .00 54, .41 1SG3342
ATOM 3342 NE2 HIS 429 112, .880 36, .327 27, .301 1, .00 54, .41 1SG3343
ATOM 3343 CD2 HIS 429 112, .120 35, .621 26, .386 1, .00 54, .41 1ΞG3344
ATOM 3344 CE1 HIS 429 114, .078 35, .774 27, .235 1, .00 54 .41 1SG3345
ATOM 3345 C HIS 429 110, .692 34, .936 23, .710 1, .00 54 .41 1SG3346
ATOM 3346 O HIS 429 109, .537 35 .304 23 .560 1, .00 54 .41 1SG3347
ATOM 3347 N LYS 430 111, .723 35 .710 23, .322 1, .00 52 .28 1SG3348
ATOM 3348 CA LYS 430 111. .443 36. .994 22, .744 1. .00 52, .28 1SG3349
ATOM 3349 CB LYS 430 112. .614 37, .986 22, .894 1, .00 52, .28 1SG3350
ATOM 3350 CG LYS 430 114. .005 37, .342 22, .828 1, .00 52, .28 1SG3351
ATOM 3351 CD LYS 430 114. .417 36. .810 21, .456 1, .00 52, .28 1SG3352
ATOM 3352 CE LYS 430 115. .701 35. .981 21. .486 1, .00 52, .28 1SG3353
ATOM 3353 NZ LYS 430 116. .850 36. .834 21, .864 1, .00 52, .28 1SG3354
ATOM 3354 C LYS 430 111. .054 36, .851 21. .306 1. .00 52. .28 1SG3355
ATOM 3355 O LYS 430 111. .889 36. .799 20. .408 1. .00 52. .28 1SG3356
ATOM 3356 N PHE 431 109. .731 36. .794 21, .060 1. .00 45. .74 1SG3357
ATOM 3357 CA PHE 431 109. .226 36, .699 19, .724 1. .00 45. .74 1SG3358
ATOM 3358 CB PHE 431 109, .058 35, .246 19, .256 1. .00 45, .74 1SG3359
ATOM 3359 CG PHE 431 108, .541 35, .240 17, .860 1, .00 45, .74 1SG3360
ATOM 3360 CDl PHE 431 107, .187 35, .293 17, .616 1. .00 45, .74 1SG3361
ATOM 3361 CD2 PHE 431 109. .409 35. .179 16. .796 1. .00 45. .74 1SG3362
ATOM 3362 CE1 PHE 431 106. .709 35, .282 16. .327 1. .00 45. .74 1SG3363
ATOM 3363 CE2 PHE 431 108. .937 35. .169 15, .506 1. .00 45. .74 1SG3364
ATOM 3364 CZ PHE 431 107. .585 35. .222 15, .269 1. .00 45. .74 1SG3365
ATOM 3365 C PHE 431 107, .871 37, .329 19, .740 1. .00 45. .74 1SG3366
ATOM 3366 O PHE 431 107, .164 37, .260 20, .743 1. .00 45, .74 1SG3367
ATOM 3367 N LEU 432 107. .478 37. .976 18. .625 1. .00 38. .06 1SG3368 r-
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ATOM 42 CB LYS 6 99..413 21..929 11..806 1.00 44..99 ISG 43
ATOM 43 CG LYS 6 100. .564 21. ,753 10. ,811 1. 00 44. .99 ISG 44
ATOM 44 CD LYS 6 100. .911 23. ,027 10. .038 1. .00 44. .99 ISG 45
ATOM 45 CE LYS 6 99. ,863 23. ,356 8. .971 1. .00 44. .99 ISG 46
ATOM 46 NZ LYS 6 100. ,202 24. ,618 8. .278 1. ,00 44. .99 ISG 47
ATOM 47 C LYS 6 100. .421 23. .982 12. .778 1. .00 44. .99 ISG 48
ATOM 48 O LYS 6 99. .756 24. ,969 12. .470 1. .00 44. .99 ISG 49
ATOM 49 N ALA 7 101. .768 24. ,014 12. .853 1. .00 44. .72 ISG 50
ATOM 50 CA ALA 7 102. .501 25. .207 12. .544 1. .00 44, .72 ISG 51
ATOM 51 CB ALA 7 103. .503 25. ,614 13. .638 1. .00 44. .72 ISG 52
ATOM 52 C ALA 7 103. .283 24. ,912 11. .309 1. .00 44. .72 ISG 53
ATOM 53 O ALA 7 103. .924 23. .868 11. .195 1. .00 44, .72 ISG 54
ATOM 54 N ARG 8 103. .242 25. .836 10. .337 1. .00 45. .34 ISG 55
ATOM 55 CA ARG 8 103. .930 25. ,578 9. .113 1. ,00 45. .34 ISG 56
ATOM 56 CB ARG 8 102, .948 25. .504 7. .942 1. .00 45. .34 ISG 57
ATOM 57 CG ARG 8 103, .424 24. .679 6, .757 1. .00 45, .34 ISG 58
ATOM 58 CD ARG 8 102. .350 24. .589 5. .676 1. .00 45. .34 ISG 59
ATOM 59 NE ARG 8 102, .799 23. .601 4 .660 1. .00 45, .34 ISG 60
ATOM 60 CZ ARG 8 101, .880 23. .060 3. .808 1. .00 45, .34 ISG 61
ATOM 61 NHl ARG 8 100, .568 23. .425 3, .899 1. .00 45, .34 ISG 62
ATOM 62 NH2 ARG 8 102, .271 22. .156 2 .865 1, .00 45 .34 ISG 63
ATOM 63 C ARG 8 104, .828 26. .741 8. .881 1. .00 45 .34 ISG 64
ATOM 64 O ARG 8 104, .372 27. .878 8. .770 1. .00 45, .34 ISG 65
ATOM 65 N ILE 9 106, .138 26, .478 8 .769 1, .00 42 .01 ISG 66
ATOM 66 CA ILE 9 107, .055 27, .555 8. .587 1. .00 42 .01 ISG 67
ATOM 67 CB ILE 9 108, .263 27. .409 9. .477 1. .00 42, .01 ISG 68
ATOM 68 CG2 ILE 9 109 .188 26. .325 8 .918 1, .00 42 .01 ISG 69
ATOM 69 CGI ILE 9 108 .969 28, .745 9 .672 1. .00 42 .01 ISG 70
ATOM 70 CDl ILE 9 110, .051 28. .690 10. .749 1. .00 42, .01 ISG 71
ATOM 71 C ILE 9 107 .436 27, .521 7 .137 1. .00 42 .01 ISG 72
ATOM 72 O ILE 9 107 .777 26, .475 6 .586 1. .00 42 .01 ISG 73
ATOM 73 N THR 10 107, .320 28, .679 6. .461 1. .00 36 .53 ISG 74
ATOM 74 CA THR 10 107 .564 28, .751 5 .049 1, .00 36 .53 ISG 75
ATOM 75 CB THR 10 106 .671 29, .781 4 .397 1, .00 36 .53 ISG 76
ATOM 76 OGl THR 10 105, .318 29. .500 4. .726 1, .00 36 .53 ISG 77
ATOM 77 CG2 THR 10 106 .815 29. .740 2 .864 1. .00 36 .53 ISG 78
ATOM 78 C THR 10 109 .005 29. .116 4 .835 1, .00 36 .53 ISG 79
ATOM 79 O THR 10 109 .733 29. .428 5 .777 1. .00 36 .53 ISG 80
ATOM 80 N GLN 11 109 .452 29 .081 3 .563 1. .00 32 .97 ISG 81
ATOM 81 CA GLN 11 110 .810 29. .374 3 .221 1, .00 32 .97 ISG 82
ATOM 82 CB GLN 11 111 .125 29. .234 1. .725 1. .00 32 .97 ISG 83
ATOM 83 CG GLN 11 112 .594 29, .538 1 .427 1. .00 32 .97 ISG 84
ATOM 84 CD GLN 11 112 .838 29, .379 -0 .062 1. .00 32 .97 ISG 85
ATOM 85 OEl GLN 11 111 .933 29, .059 -0. .832 1. .00 32, .97 ISG 86
ATOM 86 NE2 GLN 11 114 .110 29, .610 -0 .482 1. .00 3 .97 ISG 87
ATOM 87 C GLN 11 111 .094 30, .785 3 .612 1, .00 32 .97 ISG 88
ATOM 88 O GLN 11 112 .203 31, .103 4. .038 1. .00 32 .97 ISG 89
ATOM 89 N ARG 12 110 .096 31 .680 3 .477 1. .00 28 .38 ISG 90
ATOM 90 CA ARG 12 110 .325 33, .047 3 .840 1. .00 28 .38 ISG 91
ATOM 91 CB ARG 12 109 .082 33, .940 3 .691 1. .00 28. .38 ISG 92
ATOM 92 CG ARG 12 109 .335 35 .379 4 .147 1. .00 28 .38 ISG 93
ATOM 93 CD ARG 12 108 .098 36, .278 4 .107 1. .00 28 .38 ISG 94
ATOM 94 NE ARG 12 108 .486 37, .586 4. .707 1. .00 28. .38 ISG 95
ATOM 95 CZ ARG 12 107 .693 38 .683 4 .536 1. .00 28 .38 ISG 96
ATOM 96 NHl ARG 12 106 .550 38, .592 3. .795 1. .00 28 .38 ISG 97
ATOM 97 NH2 ARG 12 108 .042 39. .873 5. .107 1. .00 28. .38 ISG 98
ATOM 98 C ARG 12 110 .696 33. .065 5 .286 1, .00 28 .38 ISG 99 n <_J ri r. c T i \D r- oo ui c_ H CN r ^r in vo t^ oo on o H C ro i vo t^ co c o H CN r ^ i vD
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ATOM 156 C ALA 20 120..349 35..155 12..764 1..00 27..00 ISG 157
ATOM 157 O ALA 20 121. .262 35. .620 13. .443 1. .00 27. .00 ISG 158
ATOM 158 N GLY 21 120. .314 33. .861 12 .400 1. .00 29. .94 ISG 159
ATOM 159 CA GLY 21 121. .292 32, .943 12 .903 1. .00 29. .94 ISG 160
ATOM 160 C GLY 21 122, .671 33 .292 12 .438 1. .00 29. .94 ISG 161
ATOM 161 O GLY 21 123. .599 33, .365 13 .240 1. .00 29. .94 ISG 162
ATOM 162 N MET 22 122. .845 33 .550 11 .130 1 .00 34. .70 ISG 163
ATOM 163 CA MET 22 124. .166 33 .762 10 .617 1, .00 34. .70 ISG 164
ATOM 164 CB MET 22 124, .199 33 .796 9 .081 1, .00 34. .70 ISG 165
ATOM 165 CG MET 22 123, .712 32 .452 8 .519 1 .00 34. .70 ISG 166
ATOM 166 SD MET 22 124, .635 31 .011 9 .145 1 .00 34. .70 ISG 167
ATOM 167 CE MET 22 123. .414 29, .705 8. .814 1. .00 34. ,70 ISG 168
ATOM 168 C MET 22 124. .747 35, .001 11. .223 1. .00 34. .70 ISG 169
ATOM 169 O MET 22 125. .931 35, .035 11. .556 1. .00 34. ,70 ISG 170
ATOM 170 N LYS 23 123. .923 36, .047 11. .419 1. .00 37. .56 ISG 171
ATOM 171 CA LYS 23 124. .440 37, .253 11, .995 1, .00 37. .56 ISG 172
ATOM 172 CB LYS 23 123. .362 38, .339 12, .175 1. .00 37. .56 ISG 173
ATOM 173 CG LYS 23 123. .894 39, .671 12 .714 1. .00 37. .56 ISG 174
ATOM 174 CD LYS 23 122. .905 40, .829 12, .558 1. .00 37. .56 ISG 175
ATOM 175 CE LYS 23 123. .420 42, .166 13 .097 1. .00 37. .56 ISG 176
ATOM 176 NZ LYS 23 122, .450 43, .241 12 .791 1, .00 37. .56 ISG 177
ATOM 177 C LYS 23 124, .974 36, .900 13 .343 1, .00 37. .56 ISG 178
ATOM 178 O LYS 23 126. .071 37, .313 13 .717 1, .00 37. .56 ISG 179
ATOM 179 N MET 24 124, .207 36, .098 14 .104 1, .00 41. .82 ISG 180
ATOM 180 CA MET 24 124, .629 35 .691 15 .411 1, .00 41. .82 ISG 181
ATOM 181 CB MET 24 123, .539 34 .949 16 .205 1, .00 41. .82 ISG 182
ATOM 182 CG MET 24 122, .573 35 .871 16 .965 1, .00 41. .82 ISG 183
ATOM 183 SD MET 24 121, .484 36 .935 15 .969 1, .00 41, .82 ISG 184
ATOM 184 CE MET 24 122. .620 38 .351 15 .908 1, .00 41. .82 ISG 185
ATOM 185 C MET 24 125, .847 34, .825 15 .308 1, .00 41. .82 ISG 186
ATOM 186 o MET 24 126, .720 34 .887 16 .171 1, .00 41. .82 ISG 187
ATOM 187 N ILE 25 125. .935 33 .961 14 .277 1, .00 42. .91 ISG 188
ATOM 188 CA ILE 25 127, .087 33 .108 14 .187 1, .00 42. .91 ISG 189
ATOM 189 CB ILE 25 126, .948 31 .848 13 .376 1, .00 42. .91 ISG 190
ATOM 190 CG2 ILE 25 125. .838 31 .021 14 .047 1. .00 42. .91 ISG 191
ATOM 191 CGI ILE 25 126, .732 32 .079 11 .880 1, .00 42. .91 ISG 192
ATOM 192 CDl ILE 25 126, .991 30 .796 11 .088 1 .00 42. .91 ISG 193
ATOM 193 C ILE 25 128, .333 33 .864 13 .827 1. .00 42. .91 ISG 194
ATOM 194 O ILE 25 129. .426 33 .466 14 .224 1, .00 42. .91 ISG 195
ATOM 195 N GLU 26 128, .226 34 .961 13 .051 1, .00 41. .71 ISG 196
ATOM 196 CA GLU 26 129, .415 35 .655 12 .633 1, .00 41. .71 ISG 197
ATOM 197 CB GLU 26 129, .145 36 .910 11 .775 1, .00 41. .71 ISG 198
ATOM 198 CG GLU 26 128, .429 38 .045 12 .511 1, .00 41. .71 ISG 199
ATOM 199 CD GLU 26 128, .275 39 .216 11 .547 1, .00 41. .71 ISG 200
ATOM 200 OEl GLU 26 128, .838 39 .139 10 .422 1, .00 41. .71 ISG 201
ATOM 201 OE2 GLU 26 127, .593 40 .205 11 .926 1. .00 41. .71 ISG 202
ATOM 202 C GLU 26 130, .192 36 .091 13 .838 1, .00 41. .71 ISG 203
ATOM 203 O GLU 26 131, .419 36, .021 13 .847 1, .00 41. .71 ISG 204
ATOM 204 N GLN 27 129, .498 36 .534 14 .902 1, .00 41. .57 ISG 205
ATOM 205 CA GLN 27 130, .164 37 .025 16 .075 1, .00 41. .57 ISG 206
ATOM 206 CB GLN 27 129, .164 37, .502 17 .142 1, .00 41. .57 ISG 207
ATOM 207 CG GLN 27 129, .813 38 .062 18 .406 1, .00 41. .57 ISG 208
ATOM 208 CD GLN 27 128, .688 38, .516 19 .325 1, .00 41. .57 ISG 209
ATOM 209 OEl GLN 27 128, .927 38, .993 20, .433 1, .00 41. .57 ISG 210
ATOM 210 NE2 GLN 27 127, .422 38, .368 18, .849 1, .00 41. .57 ISG 211
ATOM 211 C GLN 27 130, .997 35, .922 16, .654 1, .00 41. .57 ISG 212
ATOM 212 O GLN 27 132. .123 36. .148 17. .092 1. .00 41. 57 ISG 213 ATOM 213 N MET 28 130..466 34,.689 16..672 1..00 41,.20 ISG 214
ATOM 214 CA MET 28 131. .192 33, .577 17. .214 1. .00 41, .20 ISG 215
ATOM 215 CB MET 28 130. .361 32. .285 17. .253 1. ,00 41. .20 ISG 216
ATOM 216 CG MET 28 129. .211 32. .341 18. .259 1. ,00 41. .20 ISG 217
ATOM 217 SD MET 28 129. .745 32. .453 19. .994 1. .00 41, .20 ISG 218
ATOM 218 CE MET 28 128. .082 32. .263 20. .699 1. .00 41, .20 ISG 219
ATOM 219 C MET 28 132 .405 33 .318 16. .369 1. .00 41 .20 ISG 220
ATOM 220 O MET 28 133 .468 32. .984 16, .889 1. .00 41 .20 ISG 221
ATOM 221 N LEU 29 132, .279 33. .462 15, .035 1, .00 42 .75 ISG 222
ATOM 222 CA LEU 29 133 .379 33. .194 14, .147 1. .00 42 .75 ISG 223
ATOM 223 CB LEU 29 133, .028 33, .342 12. .649 1. .00 42 .75 ISG 224
ATOM 224 CG LEU 29 132, .283 32, .146 12, .023 1. .00 42 .75 ISG 225
ATOM 225 CD2 LEU 29 131, .082 31. .720 12 , .877 1. .00 42 .75 ISG 226
ATOM 226 CDl LEU 29 133, .243 30, .978 11. .739 1. .00 42, .75 ISG 227
ATOM 227 C LEU 29 134, .516 34, .131 14. .418 1. .00 42, .75 ISG 228
ATOM 228 O LEU 29 135, .676 33, .724 14. .388 1. .00 42, .75 ISG 229
ATOM 229 N LYS 30 134. .222 35, .415 14. .692 1. .00 44, .26 ISG 230
ATOM 230 CA LYS 30 135 .259 36 .391 14. .899 1. .00 44 .26 ISG 231
ATOM 231 CB LYS 30 134 .749 37 .849 14. .960 1. .00 44 .26 ISG 232
ATOM 232 CG LYS 30 133 .670 38 .129 16, .003 1. .00 44 .26 ISG 233
ATOM 233 CD LYS 30 133 .355 39 .615 16, .203 1. .00 44 .26 ISG 234
ATOM 234 CE LYS 30 132, .066 39, .856 16, .994 1. .00 44 .26 ISG 235
ATOM 235 NZ LYS 30 131, .875 41, .303 17, .241 1, .00 44 .26 ISG 236
ATOM 236 C LYS 30 136, .056 36, .059 16, .129 1. .00 44 .26 ISG 237
ATOM 237 O LYS 30 137, .216 36, .450 16, .245 1. .00 44 .26 ISG 238
ATOM 238 N GLU 31 135, .439 35, .346 17, .089 1. .00 45 .84 ISG 239
ATOM 239 CA GLU 31 136, .020 34, .969 18, .352 1. .00 45 .84 ISG 240
ATOM 240 CB GLU 31 134, .995 34, .363 19. .326 1. .00 45, .84 ISG 241
ATOM 241 CG GLU 31 133, .951 35, .378 19. .799 1. .00 45, .84 ISG 242
ATOM 242 CD GLU 31 133 .034 34 .701 20, .808 1. .00 45 .84 ISG 243
ATOM 243 OEl GLU 31 132 .598 33 .550 20, .542 1. .00 45 .84 ISG 244
ATOM 244 OE2 GLU 31 132 .762 35 .330 21, .865 1, .00 45 .84 ISG 245
ATOM 245 C GLU 31 137 .142 33 .979 18, .193 1. .00 45 .84 ISG 246
ATOM 246 O GLU 31 137, .958 33 .837 19, .099 1. .00 45 .84 ISG 247
ATOM 247 N LYS 32 137 .192 33, .232 17, .073 1. .00 48 .20 ISG 248
ATOM 248 CA LYS 32 138, .165 32. .193 16, .848 1. .00 48 .20 ISG 249
ATOM 249 CB LYS 32 138, .223 31. .742 15, .376 1. .00 48 .20 ISG 250
ATOM 250 CG LYS 32 139, .432 30. .861 15, .043 1. .00 48, .20 ISG 251
ATOM 251 CD LYS 32 139, .381 30. .239 13. .645 1. .00 48. .20 ISG 252
ATOM 252 CE LYS 32 140, .734 29. .716 13. .149 1. .00 48. .20 ISG 253
ATOM 253 NZ LYS 32 140 .989 28 .353 13. .665 1, .00 48 .20 ISG 254
ATOM 254 C LYS 32 139 .546 32 .638 17, .208 1. .00 48 .20 ISG 255
ATOM 255 O LYS 32 139 .965 33 .757 16, .917 1. .00 48 .20 ISG 256
ATOM 256 N LYS 33 140, .301 31 .737 17, .873 1. .00 49. .46 ISG 257
ATOM 257 CA LYS 33 141, .647 32 .057 18, .239 1. .00 49, .46 ISG 258
ATOM 258 CB LYS 33 141, .954 31. .839 19. .730 1. .00 49, .46 ISG 259
ATOM 259 CG LYS 33 141, .263 32. .855 20. .639 1. .00 49, .46 ISG 260
ATOM 260 CD LYS 33 141, .666 34. .301 20. .341 1. ,00 49, .46 ISG 261
ATOM 261 CE LYS 33 143. .092 34. .643 20. .776 1. .00 49, .46 ISG 262
ATOM 262 NZ LYS 33 143, .180 34. .644 22. .253 1. .00 49. .46 ISG 263
ATOM 263 C LYS 33 142. .557 31. .165 17. .463 1. .00 49. .46 ISG 264
ATOM 264 O LYS 33 142. .428 29 .942 17. .490 1. .00 49. .46 ISG 265
ATOM 265 N LEU 34 143. .508 31. .776 16, .732 1. .00 50, .50 ISG 266
ATOM 266 CA LEU 34 144. .456 31, .016 15. .980 1. .00 50, .50 ISG 267
ATOM 267 CB LEU 34 144. .620 31, .500 14. .529 1. .00 50, .50 ISG 268
ATOM 268 CG LEU 34 145. .642 30, .686 13. .714 1. .00 50. .50 ISG 269
ATOM 269 CD2 LEU 34 145. .931 31. .348 12. .358 1. .00 50. .50 ISG 270 ATOM 270 CDl LEU 34 145..203 29..219 13..572 1.00 50.50 ISG 271
ATOM 271 C LEU 34 145. .765 31. .156 16. .695 1. 00 50. .50 ISG 272
ATOM 272 O LEU 34 146. ,099 32. .206 17. .242 1. 00 50. 50 ISG 273
ATOM 273 N PRO 35 146. .498 30. .081 16. .703 1. 00 48. .93 ISG 274
ATOM 274 CA PRO 35 147. .752 30. .021 17. .405 1. ,00 48. .93 ISG 275
ATOM 275 CD PRO 35 145. .888 28. .771 16. .570 1. ,00 48. .93 ISG 276
ATOM 276 CB PRO 35 148. .069 28. .532 17, .578 1. .00 48. .93 ISG 277
ATOM 277 CG PRO 35 147. .074 27. .803 16, .656 1. .00 48. .93 ISG 278
ATOM 278 C PRO 35 148. .835 30. .787 16, .718 1. ,00 48. .93 ISG 279
ATOM 279 O PRO 35 148, .641 31, .247 15, .595 1. ,00 48. .93 ISG 280
ATOM 280 N ASP 36 149. ,971 30. .981 17. .410 1. ,00 43. .92 ISG 281
ATOM 281 CA ASP 36 151. .082 31. .664 16. .820 1. 00 43. 92 ISG 282
ATOM 282 CB ASP 36 151. ,819 32. .595 17. .797 1. ,00 43. ,92 ISG 283
ATOM 283 CG ASP 36 152. .335 31. .764 18. .959 1. 00 43. ,92 ISG 284
ATOM 284 ODl ASP 36 151. .536 30. .960 19. .509 1. .00 43. .92 ISG 285
ATOM 285 OD2 ASP 36 153. ,535 31. .917 19. .310 1. .00 43. ,92 ISG 286
ATOM 286 C ASP 36 152. .037 30. .627 16. .331 1. .00 43. .92 ISG 287
ATOM 287 O ASP 36 152. .248 29. .609 16, .988 1. .00 43. .92 ISG 288
ATOM 288 N LEU 37 152. .620 30. .838 15. .132 1. .00 38. .30 ISG 289
ATOM 289 CA LEU 37 153. .534 29, .840 14. .664 1. ,00 38. .30 ISG 290
ATOM 290 CB LEU 37 153, .226 29, .245 13. .278 1. .00 38. .30 ISG 291
ATOM 291 CG LEU 37 151. .993 28, .321 13, .304 1. .00 38. .30 ISG 292
ATOM 292 CD2 LEU 37 151, .969 27, .465 14 , .581 1. .00 38. .30 ISG 293
ATOM 293 CDl LEU 37 151. .888 27, .473 12, .026 1. .00 38. .30 ISG 294
ATOM 294 C LEU 37 154. .925 30, .366 14, .659 1. .00 38. .30 ISG 295
ATOM 295 O LEU 37 155. .230 31, .401 14 .065 1. .00 38, .30 ISG 296
ATOM 296 N SER 38 155. .810 29, .629 15, .353 1. .00 33 .38 ISG 297
ATOM 297 CA SER 38 157. .194 29, .978 15 .412 1. .00 33, .38 ISG 298
ATOM 298 CB SER 38 157 .680 30 .284 16, .838 1. .00 33, .38 ISG 299
ATOM 299 OG SER 38 156. .970 31, .395 17 .366 1. .00 33 .38 ISG 300
ATOM 300 C SER 38 157, .939 28 .775 14 .937 1. .00 33. .38 ISG 301
ATOM 301 O SER 38 157, .568 27, .643 15 .243 1. .00 33 .38 ISG 302
ATOM 302 N GLY 39 159 .014 28 .993 14 .158 1. .00 31. .25 ISG 303
ATOM 303 CA GLY 39 159, .777 27, .887 13 .665 1, .00 31 .25 ISG 304
ATOM 304 C GLY 39 161, .095 28 .422 13 .206 1. .00 31 .25 ISG 305
ATOM 305 O GLY 39 161, .278 29 .633 13 .090 1 .00 31 .25 ISG 306
ATOM 306 N SER 40 162. .059 27 .510 12 .965 1, .00 3 .89 ISG 307
ATOM 307 CA SER 40 163 .364 27 .875 12 .490 1 .00 32 .89 ISG 308
ATOM 308 CB SER 40 164, .487 26 .932 12 .962 1 .00 32 .89 ISG 309
ATOM 309 OG SER 40 164 .630 26 .988 14 .372 1 .00 32 .89 ISG 310
ATOM 310 C SER 40 163 .343 27 .776 11 .003 1, .00 32 .89 ISG 311
ATOM 311 O SER 40 162 .356 27 .339 10 .416 1 .00 32 .89 ISG 312
ATOM 312 N GLU 41 164 .436 28 .214 10 .349 1 .00 3 .29 ISG 313
ATOM 313 CA GLU 41 164 .504 28 .095 8 .924 1, .00 34 .29 ISG 314
ATOM 314 CB GLU 41 163 .727 29 .193 8 .178 1 .00 34 .29 ISG 315
ATOM 315 CG GLU 41 163 .798 29 .064 6 .656 1, .00 34 .29 ISG 316
ATOM 316 CD GLU 41 162 .992 30 .204 6 .053 1 .00 34 .29 ISG 317
ATOM 317 OEl GLU 41 162 .434 31 .015 6 .839 1 .00 34 .29 ISG 318
ATOM 318 OE2 GLU 41 162 .922 30 .280 4 .797 1 .00 34 .29 ISG 319
ATOM 319 C GLU 41 165 .932 28 .208 8 .523 1 .00 34 .29 ISG 320
ATOM 320 O GLU 41 166 .747 28 .767 9 .255 1 .00 34 .29 ISG 321
ATOM 321 N SER 42 166 .275 27 .627 7 .356 1 .00 34 .88 ISG 322
ATOM 322 CA SER 42 167 .599 27 .750 6 .830 1 .00 34 .88 ISG 323
ATOM 323 CB SER 42 168 .495 26 .533 7 .117 1 .00 3 .88 ISG 324
ATOM 324 OG SER 42 169 .787 26 .737 6 .562 1 .00 34 .88 ISG 325
ATOM 325 C SER 42 167 .458 27 .857 5 .347 1 .00 34 .88 ISG 326
ATOM 326 O SER 42 166 .889 26, .981 4, .699 1, .00 34 .88 ISG 327 ffi Ol O H N (n * ιn ιo ^ ω ιΛ O ri f^ ι 1, l ^D ^ ι!O Oι O ri ι m ^ ι ιo ^ ffl O^ O H . n ^ ι ιo ^ ω ol O H c. m ^ ιn ιo ^ (D ιJ O H c. m ^ r. c. ι . cn n ι . m ( . ( . (n n fn ^ * 'f « * ^ ^ * * * ι ln ι ι _ ι _ ι ιo ιD ιo ιo ^ ^D lD lD ιo ιo ^ ^ ^ ^ ^ ^ ^ ^ oJ ω co cD α)
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ATOM 384 OD2 ASP 49 163..867 32..200 9..269 1.,00 48..44 ISG 385
ATOM 385 C ASP 49 165. .942 31, .475 11. .673 1. .00 48. .44 ISG 386
ATOM 386 O ASP 49 165. .319 30, .472 11. .334 1. .00 48. .44 ISG 387
ATOM 387 N TYR 50 165. .829 32, .018 12. .891 1. .00 52. .42 ISG 388
ATOM 388 CA TYR 50 164. .915 31. .502 13. .849 1. ,00 52, .42 ISG 389
ATOM 389 CB TYR 50 165. .447 30. .274 14. .622 1. .00 52, .42 ISG 390
ATOM 390 CG TYR 50 164. .386 29. .787 15. .560 1. .00 52, .42 ISG 391
ATOM 391 CDl TYR 50 163, .205 29. .272 15. .080 1. .00 52, .42 ISG 392
ATOM 392 CD2 TYR 50 164, .582 29. .824 16. .922 1. .00 52. .42 ISG 393
ATOM 393 CE1 TYR 50 162, .230 28, .820 15. .937 1. .00 52. .42 ISG 394
ATOM 394 CE2 TYR 50 163. .612 29, .375 17. .788 1. .00 52. .42 ISG 395
ATOM 395 CZ TYR 50 162 .432 28 .873 17, .295 1. .00 52 .42 ISG 396
ATOM 396 OH TYR 50 161 .433 28 .410 18, .178 1. .00 52 .42 ISG 397
ATOM 397 C TYR 50 164 .686 32 .632 14, .785 1. .00 52 .42 ISG 398
ATOM 398 O TYR 50 164 .130 33 .661 14, .390 1. .00 52 .42 ISG 399
ATOM 399 N VAL 51 165 .132 32 .451 16, .047 1. .00 54 .44 ISG 400
ATOM 400 CA VAL 51 164 .782 33 .422 17, .021 1, .00 54 .44 ISG 401
ATOM 401 CB VAL 51 165 .168 34 .826 16, .649 1. .00 54 .44 ISG 402
ATOM 402 CGI VAL 51 164 .741 35 .788 17, .774 1, .00 54 .44 ISG 403
ATOM 403 CG2 VAL 51 166 .685 34 .838 16, .388 1, .00 54 .44 ISG 404
ATOM 404 C VAL 51 163 .322 33 .220 16, .958 1, .00 54 .44 ISG 405
ATOM 405 0 VAL 51 162 .869 32 .077 16. .949 1. .00 54 .44 ISG 406
ATOM 406 N ASN 52 162 .525 34 .280 16, .918 1. .00 60 .06 ISG 407
ATOM 407 CA ASN 52 161 .192 33 .881 16, .655 1. .00 60 .06 ISG 408
ATOM 408 CB ASN 52 160 .138 34 .756 17. .354 1. .00 60 .06 ISG 409
ATOM 409 CG ASN 52 160 .233 34 .513 18, .854 1. .00 60 .06 ISG 410
ATOM 410 ODl ASN 52 160 .306 33 .372 19. .308 1. .00 60 .06 ISG 411
ATOM 411 ND2 ASN 52 160 .238 35 .617 19. .648 1. .00 60 .06 ISG 412
ATOM 412 C ASN 52 160 .989 34 .042 15, .181 1. .00 60 .06 ISG 413
ATOM 413 0 ASN 52 160 .507 35 .095 14 , .771 1. .00 60 .06 ISG 414
ATOM 414 N TYR 53 161 .384 33 .057 14 , .325 1. .00 66 .14 ISG 415
ATOM 415 CA TYR 53 160 .853 33 .239 13, .005 1. .00 66 .14 ISG 416
ATOM 416 CB TYR 53 161 .292 32 .147 12. .007 1. .00 66 .14 ISG 417
ATOM 417 CG TYR 53 160 .283 32, .004 10, .910 1. .00 66 .14 ISG 418
ATOM 418 CDl TYR 53 159 .206 31, .160 11, .086 1. .00 66 .14 ISG 419
ATOM 419 CD2 TYR 53 160 .399 32 .675 9, .715 1. .00 66 .14 ISG 420
ATOM 420 CE1 TYR 53 158 .255 30 .990 10, .110 1. .00 66 .14 ISG 421
ATOM 421 CE2 TYR 53 159. .449 32, .509 8 , .730 1. .00 66 .14 ISG 422
ATOM 422 CZ TYR 53 158, .376 31, .669 8. .925 1. .00 66 .14 ISG 423
ATOM 423 OH TYR 53 157, .401 31, .498 7. .919 1. .00 66 .14 ISG 424
ATOM 424 C TYR 53 159. .434 33, .031 13. .339 1. .00 66 .14 ISG 425
ATOM 425 O TYR 53 159, .061 31, .926 13. .719 1. .00 66. .14 ISG 426
ATOM 426 N ASN 54 158, .599 34, .079 13. .260 1. .00 62. .27 ISG 427
ATOM 427 CA ASN 54 157, .309 33, .757 13. .766 1. .00 62, .27 ISG 428
ATOM 428 CB ASN 54 157, .239 33, .741 15. .303 1. .00 62, .27 ISG 429
ATOM 429 CG ASN 54 157, .472 35, .157 15. .811 1. .00 62 , .27 ISG 430
ATOM 430 ODl ASN 54 158, .152 35, .958 15. .172 1. .00 62. .27 ISG 431
ATOM 431 ND2 ASN 54 156, .890 35, .476 16. .998 1. .00 62, .27 ISG 432
ATOM 432 C ASN 54 156, .273 34. .715 13. .307 1. ,00 62, .27 ISG 433
ATOM 433 0 ASN 54 156. .543 35. .864 12. .959 1. ,00 62, .27 ISG 434
ATOM 434 N PHE 55 155, .033 34. .200 13. .290 1. ,00 58, .60 ISG 435
ATOM 435 CA PHE 55 153. .863 34. .971 13. .021 1. ,00 58. .60 ISG 436
ATOM 436 CB PHE 55 153. .045 34. .453 11. .828 1. .00 58. .60 ISG 437
ATOM 437 CG PHE 55 153. .826 34. .761 10. ,598 1. 00 58. .60 ISG 438
ATOM 438 CDl PHE 55 154. .943 34. .029 10. ,273 1. .00 58. .60 ISG 439
ATOM 439 CD2 PHE 55 153. .435 35. .780 9. ,762 1. 00 58. .60 ISG 440
ATOM 440 CE1 PHE 55 155. .661 34. .313 9. .137 1. .00 58, .60 ISG 441 ATOM 441 CE2 PHE 55 154..150 36..068 8..623 1..00 58..60 ISG 442
ATOM 442 CZ PHE 55 155. .266 35, .334 8. .308 1. .00 58. .60 ISG 443
ATOM 443 C PHE 55 153. .035 34. .799 14. .252 1. .00 58. .60 ISG 444
ATOM 444 O PHE 55 152, .774 33. .671 14, .668 1. .00 58. .60 ISG 445
ATOM 445 N SER 56 152, .606 35. .912 14, .880 1. .00 50. .51 ISG 446
ATOM 446 CA SER 56 151, .882 35, .761 16, .108 1. .00 50. .51 ISG 447
ATOM 447 CB SER 56 152 .804 35, .653 17 .335 1, .00 50. .51 ISG 448
ATOM 448 OG SER 56 153 .695 34. .558 17 .184 1. .00 50. .51 ISG 449
ATOM 449 C SER 56 151. .019 36 .967 16 .317 1. .00 50, .51 ISG 450
ATOM 450 O SER 56 150. .965 37. .867 15 .479 1. .00 50. .51 ISG 451
ATOM 451 N ASN 57 150 .307 36, .992 17 .465 1, .00 43, .00 ISG 452
ATOM 452 CA ASN 57 149 .452 38. .088 17, .829 1. .00 43. .00 ISG 453
ATOM 453 CB ASN 57 150 .221 39. .388 18 .123 1. .00 43, .00 ISG 454
ATOM 454 CG ASN 57 151, .026 39. .189 19, .399 1. .00 43. .00 ISG 455
ATOM 455 ODl ASN 57 150, .654 38. .405 20, .271 1. .00 43. .00 ISG 456
ATOM 456 ND2 ASN 57 152 .164 39. .924 19 .517 1, .00 43, .00 ISG 457
ATOM 457 C ASN 57 148 .510 38. .345 16 .704 1. .00 43, .00 ISG 458
ATOM 458 O ASN 57 148, .315 39. .485 16 .286 1. .00 43, .00 ISG 459
ATOM 459 N ILE 58 147 .857 37. .275 16 .225 1, .00 41, .57 ISG 460
ATOM 460 CA ILE 58 147 .009 37. .366 15 .079 1, .00 41 .57 ISG 461
ATOM 461 CB ILE 58 147, .140 36. .127 14 .244 1, .00 41, .57 ISG 462
ATOM 462 CG2 ILE 58 148, .648 35. .890 14. .042 1, .00 41, .57 ISG 463
ATOM 463 CGI ILE 58 146, .534 34. .911 14 .952 1, .00 41, .57 ISG 464
ATOM 464 CDl ILE 58 146, .549 33. .672 14 .066 1, .00 41, .57 ISG 465
ATOM 465 C ILE 58 145 .600 37, .477 15 .571 1, .00 41, .57 ISG 466
ATOM 466 O ILE 58 145, .178 36. .748 16 .467 1 .00 41 .57 ISG 467
ATOM 467 N LYS 59 144, .839 38. .448 15 .028 1, .00 39, .65 ISG 468
ATOM 468 CA LYS 59 143 .478 38, .586 15 .460 1, .00 39 .65 ISG 469
ATOM 469 CB LYS 59 143 .187 39, .862 16 .269 1 .00 39 .65 ISG 470
ATOM 470 CG LYS 59 143, .212 41, .153 15 .448 1, .00 39, .65 ISG 471
ATOM 471 CD LYS 59 142, .533 42. .320 16, .171 1. .00 39, .65 ISG 472
ATOM 472 CE LYS 59 142, .524 43. .631 15 .384 1. .00 39, .65 ISG 473
ATOM 473 NZ LYS 59 141 .791 44. .669 16 .145 1. .00 39, .65 ISG 474
ATOM 474 C LYS 59 142 .611 38, .637 14 .246 1. .00 39, .65 ISG 475
ATOM 475 O LYS 59 143. .081 38. .904 13 .142 1. .00 39, .65 ISG 476
ATOM 476 N ILE 60 141 .301 38. .380 14 .430 1. .00 41, .82 ISG 477
ATOM 477 CA ILE 60 140 .373 38, .407 13 .335 1. .00 41, .82 ISG 478
ATOM 478 CB ILE 60 139 .233 37, .425 13 .496 1 .00 41 .82 ISG 479
ATOM 479 CG2 ILE 60 138. .168 37. .744 12, .432 1. .00 41. .82 ISG 480
ATOM 480 CGI ILE 60 139, .710 35. .959 13, .437 1. .00 41. .82 ISG 481
ATOM 481 CDl ILE 60 140, .161 35. ,492 12 .051 1. .00 41. .82 ISG 482
ATOM 482 C ILE 60 139, .776 39. .781 1 .330 1, .00 41, .82 ISG 483
ATOM 483 O ILE 60 139. .121 40. .183 14, .291 1. .00 41, .82 ISG 484
ATOM 484 N SER 61 140, .066 40. .563 12, .266 1. .00 42. .45 ISG 485
ATOM 485 CA SER 61 139, .573 41. .907 12 .118 1. .00 42. .45 ISG 486
ATOM 486 CB SER 61 140 .303 42. .682 10 .995 1, .00 42, .45 ISG 487
ATOM 487 OG SER 61 140, .037 42. .130 9 .711 1, .00 42, .45 ISG 488
ATOM 488 C SER 61 138. .111 41. .905 11. .796 1. ,00 42. .45 ISG 489
ATOM 489 O SER 61 137. .302 42. .495 12. .513 1. .00 42. .45 ISG 490
ATOM 490 N ALA 62 137. .753 41. .219 10. .689 1. .00 43. .92 ISG 491
ATOM 491 CA ALA 62 136. .410 41. .153 10 .198 1. .00 43. .92 ISG 492
ATOM 492 CB ALA 62 136. .140 42. ,141 9. .054 1. .00 43. ,92 ISG 493
ATOM 493 C ALA 62 136, .210 39. .791 9, .619 1. .00 43. .92 ISG 494
ATOM 494 O ALA 62 137, .113 39. .231 8 .998 1. .00 43. .92 ISG 495
ATOM 495 N PHE 63 135, .008 39. .213 9 .814 1. .00 46. .90 ISG 496
ATOM 496 CA PHE 63 134 , .749 37. .916 9. .267 1. .00 46. .90 ISG 497
ATOM 497 CB PHE 63 134. .589 36. 851 10. .372 1. .00 46. .90 ISG 498 ATOM 498 CG PHE 63 134..912 35..537 9..757 1..00 46..90 ISG 499
ATOM 499 CDl PHE 63 134. .088 35. .017 8. .801 1. .00 46. .90 ISG 500
ATOM 500 CD2 PHE 63 136. .055 34. .846 10. .088 1. .00 46, .90 ISG 501
ATOM 501 CE1 PHE 63 134. .380 33, .815 8. .209 1. .00 46, .90 ISG 502
ATOM 502 CE2 PHE 63 136. .352 33. .636 9. .502 1. .00 46. .90 ISG 503
ATOM 503 CZ PHE 63 135, .509 33, .113 8, .555 1. .00 46. .90 ISG 504
ATOM 504 C PHE 63 133. .423 38. .077 8. .596 1. .00 46. .90 ISG 505
ATOM 505 O PHE 63 132, .381 37. .963 9, .239 1. .00 46. .90 ISG 506
ATOM 506 N SER 64 133. .428 38. .307 7. .266 1. .00 45. .87 ISG 507
ATOM 507 CA SER 64 132. .197 38. .640 6. .607 1. .00 45. .87 ISG 508
ATOM 508 CB SER 64 132. .341 39. .640 5. .445 1, .00 45, .87 ISG 509
ATOM 509 OG SER 64 133. .027 39, .050 4. .350 1. .00 45, .87 ISG 510
ATOM 510 C SER 64 131. .543 37, .419 6. .063 1. .00 45, .87 ISG 511
ATOM 511 O SER 64 132. .167 36, .553 5. .454 1. .00 45, .87 ISG 512
ATOM 512 N PHE 65 130. .215 37. .378 6. .285 1. .00 45, .63 ISG 513
ATOM 513 CA PHE 65 129. .345 36 .293 5, .955 1, .00 45 .63 ISG 514
ATOM 514 CB PHE 65 128. .657 35. .924 7, .279 1. .00 45, .63 ISG 515
ATOM 515 CG PHE 65 128. .252 34. .509 7. .363 1. .00 45. .63 ISG 516
ATOM 516 CDl PHE 65 129. .251 33 .574 7. .399 1, .00 45 .63 ISG 517
ATOM 517 CD2 PHE 65 126. .934 34, .135 7. .473 1, .00 45 .63 ISG 518
ATOM 518 CE1 PHE 65 128. .927 32 .251 7 .504 1, .00 4 .63 ISG 519
ATOM 519 CE2 PHE 65 126. .603 32 .808 7. .578 1, .00 45 .63 ISG 520
ATOM 520 CZ PHE 65 127. .609 31, .874 7. .591 1, .00 45, .63 ISG 521
ATOM 521 C PHE 65 128 .289 36 .903 5, .074 1, .00 45 .63 ISG 522
ATOM 522 O PHE 65 127. .162 37, .099 5, .528 1, .00 45 .63 ISG 523
ATOM 523 N PRO 66 128. .606 37, .214 3, .842 1. .00 41, .68 ISG 524
ATOM 524 CA PRO 66 127. .693 37 .869 2, .941 1, .00 41 .68 ISG 525
ATOM 525 CD PRO 66 129. .717 36, .596 3, .136 1. .00 41, .68 ISG 526
ATOM 526 CB PRO 66 128 .449 37 .999 1 .620 1, .00 41 .68 ISG 527
ATOM 527 CG PRO 66 129. .394 36, .784 1, .641 1, .00 41 .68 ISG 528
ATOM 528 C PRO 66 126. .405 37, .144 2. .726 1. .00 41, .68 ISG 529
ATOM 529 O PRO 66 125. .353 37 .777 2, .808 1. .00 41 .68 ISG 530
ATOM 530 N ASN 67 126, .456 35, .825 2 , .456 1. .00 36, .43 ISG 531
ATOM 531 CA ASN 67 125. .245 35, .140 2, .123 1. .00 36 .43 ISG 532
ATOM 532 CB ASN 67 125. .177 34 .725 0, .640 1. .00 36 .43 ISG 533
ATOM 533 CG ASN 67 123. .775 34, .218 0, .316 1. .00 36, .43 ISG 534
ATOM 534 ODl ASN 67 122. .830 34 .381 1 .085 1. .00 36 .43 ISG 535
ATOM 535 ND2 ASN 67 123. .636 33 .575 -0 .874 1 .00 36 .43 ISG 536
ATOM 536 C ASN 67 125, .154 33, .882 2, .917 1. .00 36, .43 ISG 537
ATOM 537 0 ASN 67 126, .158 33 .231 3, .204 1. .00 36 .43 ISG 538
ATOM 538 N THR 68 123, .914 33, .541 3, .313 1. .00 32, .16 ISG 539
ATOM 539 CA THR 68 123, .617 32 .320 3, .994 1, .00 32 .16 ISG 540
ATOM 540 CB THR 68 123, .441 32 .476 5, .476 1. .00 32, .16 ISG 541
ATOM 541 OGl THR 68 123. .161 31, .217 6, .069 1. .00 32. .16 ISG 542
ATOM 542 CG2 THR 68 122. .289 33 .461 5, .742 1. .00 32. .16 ISG 543
ATOM 543 C THR 68 122 .305 31 .860 3 .448 1, .00 32 .16 ISG 544
ATOM 544 0 THR 68 121. .527 32, .663 2. .934 1. .00 32. .16 ISG 545
ATOM 545 N SER 69 122, .033 30 .543 3, .513 1. .00 27. .55 ISG 546
ATOM 546 CA SER 69 120. .760 30, .089 3, .040 1. .00 27. .55 ISG 547
ATOM 547 CB SER 69 120. .698 29 .877 1. .519 1, .00 27, .55 ISG 548
ATOM 548 OG SER 69 119. .403 29. .431 1, .147 1. .00 27 .55 ISG 549
ATOM 549 C SER 69 120. .451 28, .774 3. .679 1. .00 27. .55 ISG 550
ATOM 550 0 SER 69 121, .350 28 .038 4. .085 1. .00 27. .55 ISG 551
ATOM 551 N LEU 70 119, .145 28 .462 3 .814 1, .00 25. .91 ISG 552
ATOM 552 CA LEU 70 118, .747 27 .181 4. .319 1. .00 25. .91 ISG 553
ATOM 553 CB LEU 70 117. .958 27, .200 5. .639 1. .00 25. .91 ISG 554
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90 r^ ^ ιn ιo (D lJ O ri M ^ll * ιo ∞ Ol O ri ( * ιn ιo ^ o^ tIl O ri M n * l ^o ι» m O H f^ n ^ ιn ^o ^ cD Ol O ri c. ^n ^ ^ ιD ^ ιIl ri ri ri ri H ri ri ri N N M M r. i. M i. N M n n in n cn n iii cn m n ^ i '. if ij ^ 'j ^ tf ^ in i i in i in in in i i iD io io io io io io iD io o
Cl lD lO lO lD lO lO lD lO lD lD lD IO lD lD lD IO lD lD IO lD lO ID IO lD lD ID lD lD ID lD ID IO IO lD lO _ _ lO IO ID lD ID ID lD I_ ln iD IO IO lD lD lD lD lD lO ID
© o ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε s ε ε ε ε ε ε ε ε ε ε ε ε ε
O P O O O O P O O O d d d P P P O P P P d p P P O P P P P P P P P P P P O P P O P P P P P P O P P O P P P P O P P H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H rt rt ft ft ft ft ft ft < ft ft ft ft ft ft < ft ft ft ft ft < rt ft ft ft ft ft < ft ft < ft ft ft < ft ft ft < ft f^
ATOM 669 O THR 86 135..703 37.,452 6..016 1..00 29.,04 ISG 670
ATOM 670 N ALA 87 137. .565 36. .294 5. .470 1. ,00 28. .07 ISG 671
ATOM 671 CA ALA 87 138, .126 36. .467 6. .776 1. .00 28, .07 ISG 672
ATOM 672 CB ALA 87 138, .613 35. .156 7. .414 1. .00 28. .07 ISG 673
ATOM 673 C ALA 87 139. .327 37. .349 6. .648 1. .00 28, .07 ISG 674
ATOM 674 O ALA 87 140. .310 37. .000 5. .998 1, .00 28, .07 ISG 675
ATOM 675 N ASN 88 139. .286 38. .521 7, .304 1. .00 30. .09 ISG 676
ATOM 676 CA ASN 88 140 .401 39. .418 7, .244 1. .00 30. .09 ISG 677
ATOM 677 CB ASN 88 139. .976 40. .896 7, .185 1, .00 30. .09 ISG 678
ATOM 678 CG ASN 88 139. .113 41. .108 5, .948 1. .00 30. .09 ISG 679
ATOM 679 ODl ASN 88 139. .076 40. .274 5, .045 1, .00 30. .09 ISG 680
ATOM 680 ND2 ASN 88 138. .395 42. .263 5, .905 1. .00 30, .09 ISG 681
ATOM 681 C ASN 88 141 .123 39. .241 8 .541 1. .00 30 .09 ISG 682
ATOM 682 O ASN 88 140. .536 39. .408 9, .609 1. .00 30, .09 ISG 683
ATOM 683 N ILE 89 142. .422 38. .893 8, .481 1. .00 32, .59 ISG 684
ATOM 684 CA ILE 89 143 .175 38, .663 9 .683 1, .00 32 .59 ISG 685
ATOM 685 CB ILE 89 143. .706 37. .258 9, .771 1. .00 32, .59 ISG 686
ATOM 686 CG2 ILE 89 144. .633 37. .163 10. .993 1. .00 32. .59 ISG 687
ATOM 687 CGI ILE 89 142 .547 36. .247 9 .790 1, .00 32 .59 ISG 688
ATOM 688 CDl ILE 89 142, .994 34. .802 9. .572 1. .00 32. .59 ISG 689
ATOM 689 C ILE 89 14 .366 39. .572 9 .659 1, .00 32 .59 ISG 690
ATOM 690 O ILE 89 144, .888 39. .891 8. .592 1, .00 32, .59 ISG 691
ATOM 691 N SER 90 144, .806 40. .047 10, .846 1. .00 35, .88 ISG 692
ATOM 692 CA SER 90 145 .972 40. .886 10 .909 1. .00 35 .88 ISG 693
ATOM 693 CB SER 90 145 .666 42. .373 11, .147 1. .00 35, .88 ISG 694
ATOM 694 OG SER 90 145 .012 42. .915 10, .008 1. .00 35 .88 ISG 695
ATOM 695 C SER 90 146 .832 40. .381 12 .024 1. .00 35 .88 ISG 696
ATOM 696 O SER 90 146. .332 39. .843 13, .012 1. .00 35, .88 ISG 697
ATOM 697 N THR 91 148 .169 40, .522 11 .878 1, .00 38 .50 ISG 698
ATOM 698 CA THR 91 149 .051 39, .935 12 .846 1 .00 38 .50 ISG 699
ATOM 699 CB THR 91 149. .481 38. .562 12, .428 1, .00 38, .50 ISG 700
ATOM 700 OGl THR 91 150 .431 38, .667 11 .378 1, .00 38 .50 ISG 701
ATOM 701 CG2 THR 91 148 .254 37, .816 11, .873 1, .00 38, .50 ISG 702
ATOM 702 C THR 91 150 .342 40, .700 12 .849 1 .00 38 .50 ISG 703
ATOM 703 O THR 91 150 .493 41. .723 12, .183 1, .00 38 .50 ISG 704
ATOM 704 N ASP 92 151, .310 40. .190 13, .642 1, .00 40, .27 ISG 705
ATOM 705 CA ASP 92 152 .647 40. .706 13 .707 1, .00 40 .27 ISG 706
ATOM 706 CB ASP 92 153 .036 41. .253 15 .092 1 .00 40 .27 ISG 707
ATOM 707 CG ASP 92 152, .255 42. .536 15. .335 1. .00 40, .27 ISG 708
ATOM 708 ODl ASP 92 151 .612 43, .029 14, .371 1, .00 40 .27 ISG 709
ATOM 709 OD2 ASP 92 152, .295 43. .043 16, .488 1, .00 40, .27 ISG 710
ATOM 710 C ASP 92 153 .544 39. .538 13 .435 1, .00 40 .27 ISG 711
ATOM 711 O ASP 92 153, .116 38. .391 13, .544 1, .00 40, .27 ISG 712
ATOM 712 N TRP 93 154, .806 39. .798 13. .034 1. .00 43, .42 ISG 713
ATOM 713 CA TRP 93 155, .723 38. .724 12. .779 1. .00 43, .42 ISG 714
ATOM 714 CB TRP 93 155 .747 38. .298 11, .303 1, .00 43 .42 ISG 715
ATOM 715 CG TRP 93 156, .051 39. .456 10, .391 1, .00 43, .42 ISG 716
ATOM 716 CD2 TRP 93 157, .374 39. .952 10, .145 1. .00 43, .42 ISG 717
ATOM 717 CDl TRP 93 155, .198 40. .266 9. .700 1. .00 43, .42 ISG 718
ATOM 718 NE1 TRP 93 155 .909 41. .247 9, .048 1. .00 43, .42 ISG 719
ATOM 719 CE2 TRP 93 157 .250 41. .064 9 .315 1, .00 43 .42 ISG 720
ATOM 720 CE3 TRP 93 158. .590 39. .523 10. .588 1. .00 43. .42 ISG 721
ATOM 721 CZ2 TRP 93 158. .351 41. .768 8. .916 1. .00 43, .42 ISG 722
ATOM 722 CZ3 TRP 93 159. .697 40. .227 10. .172 1. .00 43. .42 ISG 723
ATOM 723 CH2 TRP 93 159. .580 41. .329 9. .354 1. .00 43. .42 ISG 724
ATOM 724 C TRP 93 157, .095 39, .206 13. .134 1. .00 43. .42 ISG 725
ATOM 725 O TRP 93 157. .338 40. ,410 13. .221 1. .00 43. .42 ISG 726 ATOM 726 N GLY 94 158..025 38..254 13..362 1..00 46..38 ISG 727
ATOM 727 CA GLY 94 159. .383 38. .578 13. .685 1. .00 46. .38 ISG 728
ATOM 728 C GLY 94 160. .227 37. .550 13. .004 1. .00 46. .38 ISG 729
ATOM 729 O GLY 94 159. .786 36, .432 12. .750 1. .00 46. .38 ISG 730
ATOM 730 N PHE 95 161. .476 37, .920 12. .679 1. .00 51, .95 ISG 731
ATOM 731 CA PHE 95 162. .372 37. .041 11. .987 1. .00 51, .95 ISG 732
ATOM 732 CB PHE 95 162. .228 37. .228 10. .462 1. .00 51, .95 ISG 733
ATOM 733 CG PHE 95 163. .327 36. .575 9. .697 1. .00 51, .95 ISG 734
ATOM 734 CDl PHE 95 164. .543 37. .207 9. .558 1. .00 51. .95 ISG 735
ATOM 735 CD2 PHE 95 163. .140 35. .356 9. .088 1. .00 51, .95 ISG 736
ATOM 736 CE1 PHE 95 165. .564 36. .628 8. .843 1. .00 51, .95 ISG 737
ATOM 737 CE2 PHE 95 164, .158 34, .774 8 .370 1. .00 51 .95 ISG 738
ATOM 738 CZ PHE 95 165, .372 35, .406 8 .248 1. .00 51 .95 ISG 739
ATOM 739 C PHE 95 163, .742 37, .464 12 .383 1. .00 51 .95 ISG 740
ATOM 740 O PHE 95 164. .003 38, .655 12 .550 1, .00 51 .95 ISG 741
ATOM 741 N GLU 96 164. .667 36, .506 12 .566 1, .00 55, .37 ISG 742
ATOM 742 CA GLU 96 165. .967 36. .983 12 .907 1. .00 55 .37 ISG 743
ATOM 743 CB GLU 96 166, .248 36. .989 14 .420 1. .00 55 .37 ISG 744
ATOM 744 CG GLU 96 167. .603 37. .598 14. .791 1. .00 55, .37 ISG 745
ATOM 745 CD GLU 96 167. .673 37. .731 16. .305 1. .00 55, .37 ISG 746
ATOM 746 OEl GLU 96 166 .601 37 .632 16 .958 1 .00 55 .37 ISG 747
ATOM 747 OE2 GLU 96 168. .800 37. .938 16 .829 1, .00 55 .37 ISG 748
ATOM 748 C GLU 96 167. .005 36. .146 12 .242 1, .00 55 .37 ISG 749
ATOM 749 O GLU 96 167, .044 34. .926 12 .405 1, .00 55 .37 ISG 750
ATOM 750 N SER 97 167, .847 36. .810 11 .427 1, .00 57 .42 ISG 751
ATOM 751 CA SER 97 169, .030 36, .196 10 .910 1, .00 57 .42 ISG 752
ATOM 752 CB SER 97 169, .585 36, .881 9 .649 1, .00 57 .42 ISG 753
ATOM 753 OG SER 97 169, .986 38. .210 9 .950 1, .00 57, .42 ISG 754
ATOM 754 C SER 97 169, .957 36. .462 12 .037 1, .00 57 .42 ISG 755
ATOM 755 O SER 97 169 .593 37 .310 12 .846 1 .00 57 .42 ISG 756
ATOM 756 N PRO 98 171, .101 35. .838 12 .147 1 .00 56 .07 ISG 757
ATOM 757 CA PRO 98 171. .940 35. .950 13 .318 1, .00 56 .07 ISG 758
ATOM 758 CD PRO 98 171, .829 35. .346 10 .991 1, .00 56 .07 ISG 759
ATOM 759 CB PRO 98 173, .304 35. .390 12 .914 1, .00 56 .07 ISG 760
ATOM 760 CG PRO 98 173. .046 34, .631 11 .598 1, .00 56 .07 ISG 761
ATOM 761 C PRO 98 172. .067 37, .336 13 .876 1, .00 56, .07 ISG 762
ATOM 762 O PRO 98 171, .593 37, .560 14, .988 1, .00 56, .07 ISG 763
ATOM 763 N LEU 99 172. .649 38. .275 13, .112 1. .00 49, .58 ISG 764
ATOM 764 CA LEU 99 172. .822 39. .628 13 .552 1 .00 49 .58 ISG 765
ATOM 765 CB LEU 99 173, .869 40. .364 12 .682 1, .00 49 .58 ISG 766
ATOM 766 CG LEU 99 174, .379 41. .744 13 .169 1, .00 49, .58 ISG 767
ATOM 767 CD2 LEU 99 173, .261 42. .765 13 .443 1, .00 49, .58 ISG 768
ATOM 768 CDl LEU 99 175, .405 42. .305 12 .173 1, .00 49. .58 ISG 769
ATOM 769 C LEU 99 171, .533 40. .397 13, .522 1, .00 49. .58 ISG 770
ATOM 770 O LEU 99 171, .252 41. .178 14, .430 1. .00 49, .58 ISG 771
ATOM 771 N PHE 100 170. .698 40. .204 12, .482 1. .00 43. .84 ISG 772
ATOM 772 CA PHE 100 169. .642 41. .165 12, .325 1. .00 43. .84 ISG 773
ATOM 773 CB PHE 100 169. .486 41, .615 10 .862 1, .00 43. .84 ISG 774
ATOM 774 CG PHE 100 168. .725 42, .896 10 .848 1, .00 43. .84 ISG 775
ATOM 775 CDl PHE 100 167. .351 42. .915 10, .859 1. .00 43. .84 ISG 776
ATOM 776 CD2 PHE 100 169. .407 44. .091 10, .823 1, .00 43. .84 ISG 777
ATOM 777 CE1 PHE 100 166. .676 44. .113 10, .844 1. .00 43. .84 ISG 778
ATOM 778 CE2 PHE 100 168. .735 45. .290 10, .808 1. .00 43. .84 ISG 779
ATOM 779 CZ PHE 100 167. .363 45. .303 10. .819 1. .00 43. .84 ISG 780
ATOM 780 C PHE 100 168. .314 40. ,669 12. .799 1. .00 43. .84 ISG 781
ATOM 781 O PHE 100 167. ,978 39. ,491 12. .683 1. .00 43. .84 ISG 782
ATOM 782 N GLN 101 167. .519 41. .605 13. .366 1. .00 36. .49 ISG 783 ATOM 783 CA GLN 101 166..200 41..291 13..834 1.,00 36..49 ISG 784
ATOM 784 CB GLN 101 165. .999 41. .579 15. .332 1. .00 36. .49 ISG 785
ATOM 785 CG GLN 101 166, .862 40. .706 16. .245 1. .00 36. .49 ISG 786
ATOM 786 CD GLN 101 166, .562 41. .095 17. .685 1. .00 36. .49 ISG 787
ATOM 787 OEl GLN 101 165. .759 41. .990 17. .945 1. .00 36. ,49 ISG 788
ATOM 788 NE2 GLN 101 167. .229 40. .408 18. .651 1. .00 36. .49 ISG 789
ATOM 789 C GLN 101 165. .234 42. .157 13. .085 1. .00 36. .49 ISG 790
ATOM 790 O GLN 101 165. .332 43. .383 13. .119 1. .00 36. .49 ISG 791
ATOM 791 N ASP 102 164. .266 41. .530 12, .384 1, .00 31. .19 ISG 792
ATOM 792 CA ASP 102 163. .287 42. .264 11, .632 1. .00 31. .19 ISG 793
ATOM 793 CB ASP 102 163 .146 41 .792 10, .173 1. .00 31, .19 ISG 794
ATOM 794 CG ASP 102 164 , .340 42. .277 9. .367 1. .00 31. .19 ISG 795
ATOM 795 ODl ASP 102 164 , .514 43. .520 9. .266 1. .00 31. .19 ISG 796
ATOM 796 OD2 ASP 102 165. .081 41, .414 8. .826 1. .00 31. .19 ISG 797
ATOM 797 C ASP 102 161. .952 42, .044 12, .264 1. .00 31. .19 ISG 798
ATOM 798 O ASP 102 161 .635 40, .944 12, .714 1. .00 31, .19 ISG 799
ATOM 799 N THR 103 161 .130 43 .109 12, .324 1. .00 28, .65 ISG 800
ATOM 800 CA THR 103 159, .818 42 , .974 12. .887 1. .00 28. .65 ISG 801
ATOM 801 CB THR 103 159, .712 43. .484 14. .295 1. .00 28, .65 ISG 802
ATOM 802 OGl THR 103 158 .450 43. .139 14. .847 1, .00 28, .65 ISG 803
ATOM 803 CG2 THR 103 159 .892 45 .011 14. .284 1. .00 28, .65 ISG 804
ATOM 804 C THR 103 158 .880 43, .780 12. .046 1, .00 28 .65 ISG 805
ATOM 805 O THR 103 159 .300 44 .657 11. .292 1 .00 28 .65 ISG 806
ATOM 806 N GLY 104 157 .568 43 .487 12, .142 1 .00 27 .88 ISG 807
ATOM 807 CA GLY 104 156, .615 44, .248 11, .389 1, .00 27, .88 ISG 808
ATOM 808 C GLY 104 155 .304 43. .534 11, .437 1, .00 27, .88 ISG 809
ATOM 809 O GLY 104 155 .239 42 .343 11, .737 1, .00 27, .88 ISG 810
ATOM 810 N GLY 105 154 .214 44 .267 11, .137 1, .00 30, .91 ISG 811
ATOM 811 CA GLY 105 152 .908 43 .677 11 .139 1 .00 30 .91 ISG 812
ATOM 812 C GLY 105 152 .681 43 .073 9 .791 1 .00 30 .91 ISG 813
ATOM 813 O GLY 105 153 , .443 43, .313 8, .856 1, .00 30, .91 ISG 814
ATOM 814 N ALA 106 151. .608 42, .268 9, .659 1, .00 37, .01 ISG 815
ATOM 815 CA ALA 106 151 .312 41 .677 8. .386 1, .00 37, .01 ISG 816
ATOM 816 CB ALA 106 151 .942 40 .286 8, .191 1, .00 37, .01 ISG 817
ATOM 817 C ALA 106 149 .830 41 .507 8 .293 1 .00 37 .01 ISG 818
ATOM 818 O ALA 106 149 .139 41 .462 9 .308 1 .00 37, .01 ISG 819
ATOM 819 N ASP 107 149 .286 41 .439 7 .061 1 .00 44 .18 ISG 820
ATOM 820 CA ASP 107 147. .876 41, .217 6, .949 1, .00 44, .18 ISG 821
ATOM 821 CB ASP 107 147 .051 42 .429 6, .466 1, .00 44, .18 ISG 822
ATOM 822 CG ASP 107 147 .530 42 .853 5, .096 1, .00 44, .18 ISG 823
ATOM 823 ODl ASP 107 148 .651 42 .430 4, .718 1, .00 44, .18 ISG 824
ATOM 824 OD2 ASP 107 146 .791 43 .611 4, .413 1, .00 44, .18 ISG 825
ATOM 825 C ASP 107 147 .636 40 .031 6 .068 1, .00 44, .18 ISG 826
ATOM 826 O ASP 107 148. .360 39. .796 5. .101 1. .00 44. .18 ISG 827
ATOM 827 N LEU 108 146. .615 39. .230 6. .436 1. .00 48. .44 ISG 828
ATOM 828 CA LEU 108 146. .255 38, .029 5, .741 1. .00 48. .44 ISG 829
ATOM 829 CB LEU 108 146. .215 36 .796 6, .658 1. .00 48. .44 ISG 830
ATOM 830 CG LEU 108 145 .830 35 .500 5, .924 1. .00 48. .44 ISG 831
ATOM 831 CD2 LEU 108 145 .219 34 .459 6, .871 1, .00 48, .44 ISG 832
ATOM 832 CDl LEU 108 146 .997 34 .964 5, .084 1. .00 48, .44 ISG 833
ATOM 833 C LEU 108 144 , .849 38, .203 5, .253 1, .00 48. .44 ISG 834
ATOM 834 O LEU 108 144 , .051 38, .913 5, .863 1, .00 48. .44 ISG 835
ATOM 835 N PHE 109 144 , .517 37, .554 4, .120 1. .00 48. .37 ISG 836
ATOM 836 CA PHE 109 143 , .202 37, .648 3, .556 1. .00 48. .37 ISG 837
ATOM 837 CB PHE 109 143 .257 38 .444 2, .236 1. .00 48, .37 ISG 838
ATOM 838 CG PHE 109 141 .912 38 .621 1, .625 1. .00 48, .37 ISG 839
ATOM 839 CDl PHE 109 141, .354 37, .631 0. .853 1. .00 48. .37 ISG 840 ATOM 840 CD2 PHE 109 141..221 39..798 1..803 1..00 48..37 ISG 841
ATOM 841 CE1 PHE 109 140. .117 37. .815 0. .285 1. .00 48. .37 ISG 842
ATOM 842 CE2 PHE 109 139. .982 39. .984 1. .237 1. .00 48. .37 ISG 843
ATOM 843 CZ PHE 109 139. .426 38. .987 0. .475 1. .00 48. .37 ISG 844
ATOM 844 C PHE 109 142. .777 36. ,246 3. .242 1. ,00 48. .37 ISG 845
ATOM 845 O PHE 109 143. .472 35. .528 2. .524 1. .00 48. .37 ISG 846
ATOM 846 N LEU 110 141. .622 35. .804 3, .777 1. .00 43. .50 ISG 847
ATOM 847 CA LEU 110 141. .199 34. .470 3. .470 1. .00 43. .50 ISG 848
ATOM 848 CB LEU 110 141. .064 33. .594 4. .723 1. .00 43, .50 ISG 849
ATOM 849 CG LEU 110 141, .059 32. .099 4. .388 1. .00 43, .50 ISG 850
ATOM 850 CD2 LEU 110 140, .605 31, .246 5, .577 1. .00 43 .50 ISG 851
ATOM 851 CDl LEU 110 142. .435 31. .680 3. .842 1. .00 43. .50 ISG 852
ATOM 852 C LEU 110 139. .853 34. .636 2, .837 1. .00 43. .50 ISG 853
ATOM 853 O LEU 110 138. .956 35. .233 3, .429 1. .00 43, .50 ISG 854
ATOM 854 N SER 111 139, .669 34, .129 1, .601 1. .00 37 .35 ISG 855
ATOM 855 CA SER 111 138, .412 34, .365 0, .947 1, .00 37, .35 ISG 856
ATOM 856 CB SER 111 138, .508 35, .400 -0 .185 1. .00 37 .35 ISG 857
ATOM 857 OG SER 111 137. .244 35. .599 -0, .801 1. .00 37, .35 ISG 858
ATOM 858 C SER 111 137. .925 33, .103 0, .318 1. .00 37, .35 ISG 859
ATOM 859 0 SER 111 138. .661 32, .127 0, .190 1. .00 37, .35 ISG 860
ATOM 860 N GLY 112 136. .642 33, .105 -0, .096 1. .00 33 .64 ISG 861
ATOM 861 CA GLY 112 136, .080 31, .966 -0 .753 1. .00 33 .64 ISG 862
ATOM 862 C GLY 112 135, .876 30, .886 0 .258 1. .00 33 .64 ISG 863
ATOM 863 0 GLY 112 136, .092 29 .712 -0 .038 1 .00 33 .64 ISG 864
ATOM 864 N VAL 113 135. .462 31. .260 1 .486 1. .00 33, .51 ISG 865
ATOM 865 CA VAL 113 135, .241 30. .279 2 .510 1, .00 33 .51 ISG 866
ATOM 866 CB VAL 113 135, .418 30. .820 3 .899 1, .00 33 .51 ISG 867
ATOM 867 CGI VAL 113 135, .103 29. .704 4 .910 1. .00 33 .51 ISG 868
ATOM 868 CG2 VAL 113 136, .841 31. .391 4 .017 1. .00 33 .51 ISG 869
ATOM 869 C VAL 113 133 .831 29 .800 2 .382 1, .00 33 .51 ISG 870
ATOM 870 0 VAL 113 132, .902 30. .593 2 .251 1. .00 33, .51 ISG 871
ATOM 871 N TYR 114 133, .650 28. .465 2 .412 1, .00 35, .34 ISG 872
ATOM 872 CA TYR 114 132, .373 27, .851 2 .192 1, .00 35, .34 ISG 873
ATOM 873 CB TYR 114 132, .508 26, .933 0 .960 1, .00 35 .34 ISG 874
ATOM 874 CG TYR 114 131, .222 26. .463 0 .381 1, .00 35 .34 ISG 875
ATOM 875 CDl TYR 114 130 .598 25, .334 0 .852 1, .00 35 .34 ISG 876
ATOM 876 CD2 TYR 114 130 .665 27 .146 -0 .676 1 .00 35 .34 ISG 877
ATOM 877 CE1 TYR 114 129, .420 24 , .914 0 .283 1. .00 35 .34 ISG 878
ATOM 878 CE2 TYR 114 129, .487 26, .730 -1 .247 1, .00 35 .34 ISG 879
ATOM 879 CZ TYR 114 128, .861 25, .608 -0 .763 1, .00 35 .34 ISG 880
ATOM 880 OH TYR 114 127, .651 25, .169 -1 .341 1. .00 35 .34 ISG 881
ATOM 881 C TYR 114 132, .089 27, .012 3 .405 1 .00 35 .34 ISG 882
ATOM 882 0 TYR 114 132 .882 26 .141 3 .759 1 .00 35 .34 ISG 883
ATOM 883 N PHE 115 130. .952 27. .259 4 .091 1, .00 35, .84 ISG 884
ATOM 884 CA PHE 115 130. .626 26, .465 5 .245 1, .00 35, .84 ISG 885
ATOM 885 CB PHE 115 130, .529 27, .263 6 .556 1. .00 35, .84 ISG 886
ATOM 886 CG PHE 115 130, .178 26, .287 7 .628 1, .00 35, .84 ISG 887
ATOM 887 CDl PHE 115 131, .149 25, .511 8 .218 1, .00 35 .84 ISG 888
ATOM 888 CD2 PHE 115 128, .874 26, .150 8 .044 1, .00 35 .84 ISG 889
ATOM 889 CE1 PHE 115 130, .823 24, .611 9 .206 1, .00 35 .84 ISG 890
ATOM 890 CE2 PHE 115 128. .541 25, .252 9, .031 1. .00 35, .84 ISG 891
ATOM 891 CZ PHE 115 129. .517 24, .480 9 .614 1. .00 35, .84 ISG 892
ATOM 892 C PHE 115 129. .286 25. .849 5 .013 1. .00 35, .84 ISG 893
ATOM 893 O PHE 115 128, .324 26. .533 4 .669 1. .00 35, .84 ISG 894
ATOM 894 N THR 116 129, .195 24. .519 5 .202 1. .00 34, .56 ISG 895
ATOM 895 CA THR 116 127, .945 23, .844 5 .022 1. .00 34, .56 ISG 896
ATOM 896 CB THR 116 127. .968 22. .807 3 , .941 1. .00 34 , .56 ISG 897 ATOM 897 OGl THR 116 128.,916 21..796 4..252 1,.00 34..56 ISG 898
ATOM 898 CG2 THR 116 128. ,329 23. .485 2. ,614 1. 00 34. .56 ISG 899
ATOM 899 C THR 116 127. .653 23. .110 6. .287 1. .00 34. .56 ISG 900
ATOM 900 O THR 116 128. .556 22, .569 6. .923 1. .00 34. .56 ISG 901
ATOM 901 N GLY 117 126. .369 23, .070 6. .687 1. .00 31. .58 ISG 902
ATOM 902 CA GLY 117 126. .026 22, .366 7. .888 1. .00 31. .58 ISG 903
ATOM 903 C GLY 117 124. ,667 21, .769 7. .700 1. .00 31. .58 ISG 904
ATOM 904 O GLY 117 123. .816 22, .330 7. .013 1. .00 31. .58 ISG 905
ATOM 905 N ILE 118 124. .423 20, .608 8. .341 1. .00 29. .42 ISG 906
ATOM 906 CA ILE 118 123. .163 19. .936 8. .209 1. .00 29. .42 ISG 907
ATOM 907 CB ILE 118 123. .294 18 .468 7. .923 1. .00 29. .42 ISG 908
ATOM 908 CG2 ILE 118 121. .891 17, .847 8. .030 1. .00 29. .42 ISG 909
ATOM 909 CGI ILE 118 123. .967 18, .226 6, .563 1. .00 29. .42 ISG 910
ATOM 910 CDl ILE 118 123. .146 18, .741 5. .383 1. ,00 29. .42 ISG 911
ATOM 911 C ILE 118 122. .457 20, .032 9. .520 1. .00 29. .42 ISG 912
ATOM 912 0 ILE 118 123. .041 19 .781 10. .573 1. .00 29. .42 ISG 913
ATOM 913 N ILE 119 121. .164 20, .410 9. .484 1. .00 28. .74 ISG 914
ATOM 914 CA ILE 119 120. ,410 20, .517 10. .698 1. ,00 28. .74 ISG 915
ATOM 915 CB ILE 119 119. ,680 21, .821 10. .848 1. .00 28. .74 ISG 916
ATOM 916 CG2 ILE 119 118. ,751 21 .707 12, .068 1. .00 28. .74 ISG 917
ATOM 917 CGI ILE 119 120 ,673 22 .992 10, .934 1, .00 28 .74 ISG 918
ATOM 918 CDl ILE 119 120. ,008 24. .363 10. .828 1. .00 28. .74 ISG 919
ATOM 919 C ILE 119 119, ,377 19, .436 10. .691 1. .00 28. .74 ISG 920
ATOM 920 0 ILE 119 118, .615 19, .291 9. .736 1. .00 28, .74 ISG 921
ATOM 921 N ILE 120 119 .331 18 .641 11, .779 1, .00 31 .35 ISG 922
ATOM 922 CA ILE 120 118, .381 17, .571 11, .869 1 .00 31 .35 ISG 923
ATOM 923 CB ILE 120 118, .975 16. .261 12. .308 1. .00 31, .35 ISG 924
ATOM 924 CG2 ILE 120 119, .516 16. .426 13, .738 1, .00 31, .35 ISG 925
ATOM 925 CGI ILE 120 117 .953 15 .123 12, .145 1. .00 31 .35 ISG 926
ATOM 926 CDl ILE 120 118, .568 13 .730 12 .270 1. .00 31 .35 ISG 927
ATOM 927 C ILE 120 117 .360 17 .966 12, .884 1, .00 31, .35 ISG 928
ATOM 928 O ILE 120 117, .691 18. .464 13. .960 1. .00 31, .35 ISG 929
ATOM 929 N LEU 121 116 .075 17 .769 12, .537 1. .00 34, .89 ISG 930
ATOM 930 CA LEU 121 114, .998 18 .152 13, .401 1, .00 34 .89 ISG 931
ATOM 931 CB LEU 121 113, .812 18, .755 12. .629 1. .00 34, .89 ISG 932
ATOM 932 CG LEU 121 114 .161 20 .020 11, .825 1. .00 34, .89 ISG 933
ATOM 933 CD2 LEU 121 114, .830 21. .083 12, .711 1. .00 34, .89 ISG 934
ATOM 934 CDl LEU 121 112 .929 20 .562 11, .086 1. .00 34, .89 ISG 935
ATOM 935 C LEU 121 114, .472 16. .918 14, .055 1. .00 34, .89 ISG 936
ATOM 936 O LEU 121 114 .274 15 .891 13 , .407 1. .00 34, .89 ISG 937
ATOM 937 N THR 122 114 .235 16 .991 15, .378 1, .00 38, .30 ISG 938
ATOM 938 CA THR 122 113, .709 15. .859 16, .077 1. .00 38. .30 ISG 939
ATOM 939 CB THR 122 114, .762 15, .022 16. .741 1. ,00 38. .30 ISG 940
ATOM 940 OGl THR 122 115, .457 15, .786 17. .715 1. .00 38. .30 ISG 941
ATOM 941 CG2 THR 122 115 .737 14, .519 15. .663 1. .00 38, .30 ISG 942
ATOM 942 C THR 122 112 .800 16 .373 17. .140 1. .00 38, .30 ISG 943
ATOM 943 0 THR 122 112. .592 17. .578 17. .274 1. .00 38, .30 ISG 944
ATOM 944 N ARG 123 112. .205 15, .448 17. .912 1. .00 42. .76 ISG 945
ATOM 945 CA ARG 123 111. .318 15, .840 18, .964 1. .00 42. .76 ISG 946
ATOM 946 CB ARG 123 109 .838 15 .640 18, .616 1. .00 42, .76 ISG 947
ATOM 947 CG ARG 123 108. .895 15 .860 19, .798 1, .00 42, .76 ISG 948
ATOM 948 CD ARG 123 107. .531 15. .214 19. .567 1. ,00 42. .76 ISG 949
ATOM 949 NE ARG 123 107. .811 13. .881 18. .962 1. ,00 42. .76 ISG 950
ATOM 950 CZ ARG 123 107. .385 12. .735 19. .571 1. .00 42. .76 ISG 951
ATOM 951 NHl ARG 123 106 .651 12 .801 20, .718 1. .00 42, .76 ISG 952
ATOM 952 NH2 ARG 123 107, .707 11, .524 19. .031 1. ,00 42. .76 ISG 953
ATOM 953 C ARG 123 111, .597 14. .956 20. .131 1. ,00 42. .76 ISG 954 ATOM 954 O ARG 123 112..103 13..845 19..981 1.00 42..76 ISG 955
ATOM 955 N ASN 124 111. .282 15. .450 21. .341 1. 00 43. .01 ISG 956
ATOM 956 CA ASN 124 111. .436 14. .633 22. .502 1. ,00 43. .01 ISG 957
ATOM 957 CB ASN 124 112. .536 15, .101 23. .477 1. ,00 43, .01 ISG 958
ATOM 958 CG ASN 124 112. .310 16, .551 23. .865 1. .00 43, .01 ISG 959
ATOM 959 ODl ASN 124 111. .334 16, .899 24. .527 1. .00 43, .01 ISG 960
ATOM 960 ND2 ASN 124 113. .259. 17, .430 23. .444 1. .00 43, .01 ISG 961
ATOM 961 C ASN 124 110. .101 14 .565 23, .172 1. .00 43, .01 ISG 962
ATOM 962 O ASN 124 109. .244 15, .423 22. .974 1. ,00 43, .01 ISG 963
ATOM 963 N ASP 125 109. .896 13 , .516 23. .984 1. .00 42. .75 ISG 964
ATOM 964 CA ASP 125 108. .646 13, .222 24. .626 1. .00 42, .75 ISG 965
ATOM 965 CB ASP 125 108. .695 11, .962 25. .506 1. .00 42, .75 ISG 966
ATOM 966 CG ASP 125 108, .761 10 .738 24. .605 1. .00 42 .75 ISG 967
ATOM 967 ODl ASP 125 108. ,529 10, .889 23. .376 1. .00 42, .75 ISG 968
ATOM 968 OD2 ASP 125 109. .046 9. .633 25. .139 1. .00 42, .75 ISG 969
ATOM 969 C ASP 125 108, .267 14 .352 25, .526 1. .00 42 .75 ISG 970
ATOM 970 O ASP 125 107. .084 14, .544 25, .802 1. .00 42, .75 ISG 971
ATOM 971 N PHE 126 109. .253 15, .131 26. .011 1. .00 42, .43 ISG 972
ATOM 972 CA PHE 126 108, .953 16 .239 26, .875 1. .00 42 .43 ISG 973
ATOM 973 CB PHE 126 110. ,174 17, .088 27, .261 1. .00 42, .43 ISG 974
ATOM 974 CG PHE 126 109, ,738 17 .933 28, .409 1. .00 42 .43 ISG 975
ATOM 975 CDl PHE 126 109. ,107 19, .137 28, .201 1, .00 42 .43 ISG 976
ATOM 976 CD2 PHE 126 109. ,939 17, .507 29, .701 1. .00 42 .43 ISG 977
ATOM 977 CE1 PHE 126 108. .701 19 .914 29, .260 1, .00 42 .43 ISG 978
ATOM 978 CE2 PHE 126 109. .535 18, .278 30, .765 1. .00 42 .43 ISG 979
ATOM 979 CZ PHE 126 108. .916 19, .485 30 .547 1. .00 42 .43 ISG 980
ATOM 980 C PHE 126 108. .035 17 .100 26, .071 1, .00 42 .43 ISG 981
ATOM 981 O PHE 126 107, .176 17, .802 26. .606 1. .00 42 .43 ISG 982
ATOM 982 N GLY 127 108, .208 17 .059 24. .738 1. .00 40 .75 ISG 983
ATOM 983 CA GLY 127 107, .317 17 .771 23 .877 1, .00 40 .75 ISG 984
ATOM 984 C GLY 127 108. .040 18. .914 23. .259 1. .00 40 .75 ISG 985
ATOM 985 O GLY 127 107. .460 19 .660 22, .470 1, .00 40 .75 ISG 986
ATOM 986 N HIS 128 109. .329 19. .080 23, .606 1. .00 42 .88 ISG 987
ATOM 987 CA HIS 128 110, .091 20 .145 23 .028 1. .00 42 .88 ISG 988
ATOM 988 NDl HIS 128 110, .429 20. .843 26, .324 1. .00 42 .88 ISG 989
ATOM 989 CG HIS 128 110. .757 21. .430 25, .124 1. .00 42, .88 ISG 990
ATOM 990 CB HIS 128 Ill, .230 20. .674 23, .920 1, .00 42 .88 ISG 991
ATOM 991 NE2 HIS 128 110, .119 2 .028 26 .584 1, .00 42 .88 ISG 992
ATOM 992 CD2 HIS 128 110. .562 22. .766 25, .300 1. .00 42. .88 ISG 993
ATOM 993 CE1 HIS 128 110, .055 21. .842 27, .161 1, .00 42 .88 ISG 994
ATOM 994 C HIS 128 110, .728 19. .643 21, .773 1. .00 42, .88 ISG 995
ATOM 995 O HIS 128 111, .033 18. .461 21, .620 1. .00 42 .88 ISG 996
ATOM 996 N PRO 129 110, .895 20. .554 20, .855 1 .00 44 .08 ISG 997
ATOM 997 CA PRO 129 111. .520 20. .273 19. .593 1. .00 44, .08 ISG 998
ATOM 998 CD PRO 129 110, .109 21. .775 20. .828 1. .00 44, .08 ISG 999
ATOM 999 CB PRO 129 111, .139 21 .432 18. .668 1. .00 44 .08 1SG1000
ATOM 1000 CG PRO 129 110. .660 22. .546 19. .619 1. .00 4 .08 1SG1001
ATOM 1001 C PRO 129 112, .991 20, .140 19, .805 1. .00 44, .08 1SG1002
ATOM 1002 O PRO 129 113, .500 20. .680 20, .786 1. .00 44, .08 1SG1003
ATOM 1003 N THR 130 113, .695 19, .413 18, .916 1, .00 46 .19 1SG1004
ATOM 1004 CA THR 130 115 .105 19 .262 19 .105 1. .00 46 .19 1SG1005
ATOM 1005 CB THR 130 115. .485 17. .884 19. .557 1. .00 46, .19 1SG1006
ATOM 1006 OGl THR 130 114. .809 17, .556 20, .760 1. .00 46, .19 1SG1007
ATOM 1007 CG2 THR 130 116. .998 17. .856 19. .799 1. ,00 46, .19 1SG1008
ATOM 1008 C THR 130 115. .777 19. .488 17. .788 1. .00 46, .19 1SG1009
ATOM 1009 O THR 130 115. .228 19. .161 16. .737 1. .00 46 .19 1SG1010
ATOM 1010 N LEU 131 116. .984 20. .088 17. ,814 1. .00 47. .52 1SG1011 ATOM 1011 CA LEU 131 117..742 20.276 16..610 1..00 47..52 1SG1012
ATOM 1012 CB LEU 131 117. .600 21, .667 15, .965 1. .00 47. .52 1SG1013
ATOM 1013 CG LEU 131 116. .223 21, .929 15, .325 1, .00 47. .52 1SG1014
ATOM 1014 CD2 LEU 131 116, .262 23 .170 14, .418 1, .00 47 .52 1SG1015
ATOM 1015 CDl LEU 131 115 .104 21 .988 16 .376 1. .00 47 .52 1SG1016
ATOM 1016 C LEU 131 119, .190 20, .087 16, .948 1. .00 47. .52 1SG1017
ATOM 1017 O LEU 131 119, .657 20 .539 17 .992 1, .00 47 .52 1SG1018
ATOM 1018 N LYS 132 119 .940 19 .389 16 .071 1. .00 45 .77 1SG1019
ATOM 1019 CA LYS 132 121 .346 19 .197 16 .299 1 .00 45 .77 1SG1020
ATOM 1020 CB LYS 132 121, .697 17, .837 16, .927 1. .00 45. .77 1SG1021
ATOM 1021 CG LYS 132 121 .212 17, .683 18, .371 1. .00 45, .77 1SG1022
ATOM 1022 CD LYS 132 121 .286 16 .247 18 .896 1, .00 45 .77 1SG1023
ATOM 1023 CE LYS 132 120 .802 16 .095 20 .339 1 .00 45 .77 1SG1024
ATOM 1024 NZ LYS 132 119, .328 16, .220 20, .396 1. .00 45, .77 1SG1025
ATOM 1025 C LYS 132 122 .009 19 .248 14 .960 1, .00 45 .77 1SG1026
ATOM 1026 O LYS 132 121 .352 19 .053 13 .938 1 .00 45 .77 1SG1027
ATOM 1027 N LEU 133 123, .330 19, .531 14, .905 1, .00 46, .65 1SG1028
ATOM 1028 CA LEU 133 123 .893 19, .530 13, .587 1, .00 46 .65 1SG1029
ATOM 1029 CB LEU 133 124 .749 20 .759 13 .196 1 .00 46 .65 1SG1030
ATOM 1030 CG LEU 133 126 .193 20 .865 13 .716 1 .00 46 .65 1SG1031
ATOM 1031 CD2 LEU 133 126, .717 22, .288 13, .469 1, .00 46, .65 1SG1032
ATOM 1032 CDl LEU 133 127 .126 19 .814 13, .091 1, .00 46 .65 1SG1033
ATOM 1033 C LEU 133 124 .641 18 .253 13 .383 1 .00 46 .65 1SG1034
ATOM 1034 O LEU 133 125 .515 17 .884 14 .166 1 .00 46 .65 1SG1035
ATOM 1035 N GLN 134 124, .224 17, .504 12, .342 1, .00 45, .21 1SG1036
ATOM 1036 CA GLN 134 124 .804 16, .236 12, .012 1, .00 45 .21 1SG1037
ATOM 1037 CB GLN 134 123 .998 15 .453 10 .960 1. .00 45 .21 1SG1038
ATOM 1038 CG GLN 134 122 .582 15 .066 11 .392 1 .00 45 .21 1SG1039
ATOM 1039 CD GLN 134 121, .652 16, .230 11, .081 1, .00 45 .21 1SG1040
ATOM 1040 OEl GLN 134 121 .690 17, .279 11. .722 1. .00 45 .21 1SG1041
ATOM 1041 NE2 GLN 134 120 .773 16 .036 10. .062 1, .00 45 .21 1SG1042
ATOM 1042 C GLN 134 126 .171 16 , .405 11, .430 1, .00 45. .21 1SG1043
ATOM 1043 0 GLN 134 127, .105 15, .709 11, .826 1, .00 45 .21 1SG1044
ATOM 1044 N ASP 135 126 .328 17, .334 10, .463 1, .00 44 .71 1SG1045
ATOM 1045 CA ASP 135 127 .602 17, .435 9 .810 1, .00 44 .71 1SG1046
ATOM 1046 CB ASP 135 127, .668 16 , .652 8. .487 1, .00 44, .71 1SG1047
ATOM 1047 CG ASP 135 129, .129 16, .509 8, .076 1, .00 44, .71 1SG1048
ATOM 1048 ODl ASP 135 130, .016 16, .760 8, .935 1, .00 44, .71 1SG1049
ATOM 1049 OD2 ASP 135 129 .376 16, .134 6 .899 1, .00 44 .71 1SG1050
ATOM 1050 C ASP 135 127, .890 18, .867 9, .488 1. .00 44 , .71 1SG1051
ATOM 1051 O ASP 135 126, .982 19, .683 9, .340 1. .00 44, .71 1SG1052
ATOM 1052 N CYS 136 129, .193 19, .205 9, .387 1. .00 44, .86 1SG1053
ATOM 1053 CA CYS 136 129 .599 20, .540 9, .065 1. .00 44, .86 1SG1054
ATOM 1054 CB CYS 136 130. .006 21. .337 10. .303 1. .00 44. .86 1SG1055
ATOM 1055 SG CYS 136 131, .505 20. .584 10. .973 1. .00 44. .86 1SG1056
ATOM 1056 C CYS 136 130, .836 20, .430 8. .229 1. .00 44. .86 1SG1057
ATOM 1057 O CYS 136 131, .616 19, .488 8, .374 1. .00 44, .86 1SG1058
ATOM 1058 N TYR 137 131. .033 21. .385 7. .302 1. .00 43. .02 1SG1059
ATOM 1059 CA TYR 137 132. .219 21. .375 6. .500 1. .00 43. .02 1SG1060
ATOM 1060 CB TYR 137 132, .020 20. .636 5. .165 1. .00 43. .02 1SG1061
ATOM 1061 CG TYR 137 133. .294 20. .673 4. .395 1. ,00 43. .02 1SG1062
ATOM 1062 CDl TYR 137 134. .350 19. .866 4. .752 1. ,00 43. .02 1SG1063
ATOM 1063 CD2 TYR 137 133. .425 21. .498 3. .302 1. .00 43. .02 1SG1064
ATOM 1064 CE1 TYR 137 135. .524 19. .894 4. .039 1. .00 43. .02 1SG1065
ATOM 1065 CE2 TYR 137 134. .597 21. .530 2. .583 1. .00 43. .02 1SG1066
ATOM 1066 CZ TYR 137 135. .650 20. .727 2. .954 1. .00 43. .02 1SG1067
ATOM 1067 OH TYR 137 136. .855 20. .757 2. .220 1. ,00 43. .02 1SG1068 oi o H rq ro ^ in vD r- oo on o H CN ro ^ i iD i^ eD en o H C ^ i vo t^ eD e o H c ro i in vD t^ co en o H eN r ^i i io f- oo on o ri cN ro ^i in vo t— r- t- f r- t^ t- oo oo oo oo oo co co co oo co cn cn σi on cn cn cn cn cn cn o o o o o o o o ri H H H H H H H CN CN CN CN CN CN
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ATOM 1125 CB VAL 145 150,.371 36,.062 3..494 1..00 42..79 1SG1126
ATOM 1126 CGI VAL 145 151. .518 35. .736 2. .525 1. .00 42. .79 1SG1127
ATOM 1127 CG2 VAL 145 150. .816 36, .659 4. .832 1. .00 42. .79 1SG1128
ATOM 1128 C VAL 145 150, .032 38, .218 2. .290 1. .00 42. .79 1SG1129
ATOM 1129 O VAL 145 150. .871 38. .139 1. .394 1. ,00 42. .79 1SG1130
ATOM 1130 N SER 146 149. .636 39. .407 2. .786 1. .00 45. .03 1SG1131
ATOM 1131 CA SER 146 150, .181 40, .589 2. .188 1. .00 45. .03 1SG1132
ATOM 1132 CB SER 146 149, .124 41, .680 1. .941 1. .00 45. .03 1SG1133
ATOM 1133 OG SER 146 149, .728 42, .821 1. .350 1. .00 45, .03 1SG1134
ATOM 1134 C SER 146 151, .214 41. .179 3. .087 1. .00 45. .03 1SG1135
ATOM 1135 O SER 146 150, .981 42. .186 3. .752 1. .00 45. .03 1SG1136
ATOM 1136 N PHE 147 152, .410 40. .567 3. .108 1. .00 46. .60 1SG1137
ATOM 1137 CA PHE 147 153, .500 41. .113 3. .855 1. .00 46. .60 1SG1138
ATOM 1138 CB PHE 147 154, .716 40. .181 3 , .948 1. .00 46, .60 1SG1139
ATOM 1139 CG PHE 147 155, .780 41. .012 4. .572 1. .00 46, .60 1SG1140
ATOM 1140 CDl PHE 147 155 .734 41. .301 5. .914 1. .00 46 .60 1SG1141
ATOM 1141 CD2 PHE 147 156, .818 41, .503 3, .815 1. .00 46, .60 1SG1142
ATOM 1142 CE1 PHE 147 156 .712 42, .072 6, .491 1. .00 46 .60 1SG1143
ATOM 1143 CE2 PHE 147 157, .800 42, .275 4, .390 1. .00 46, .60 1SG1144
ATOM 1144 CZ PHE 147 157, .747 42, .562 5, .732 1. .00 46, .60 1SG1145
ATOM 1145 C PHE 147 153 .949 42, .353 3, .151 1. .00 46 .60 1SG1146
ATOM 1146 O PHE 147 154, .317 43, .343 3. .780 1. .00 46, .60 1SG1147
ATOM 1147 N SER 148 153 .943 42 .312 1 .805 1. .00 46 .89 1SG1148
ATOM 1148 CA SER 148 154, .321 43, .443 1, .006 1. .00 46, .89 1SG1149
ATOM 1149 CB SER 148 153, .270 44, .565 1. .011 1. .00 46, .89 1SG1150
ATOM 1150 OG SER 148 153 .707 45 .647 0, .200 1. .00 46 .89 1SG1151
ATOM 1151 C SER 148 155, .623 44, .020 1. .479 1. .00 46, .89 1SG1152
ATOM 1152 O SER 148 155 .663 45 .169 1, .913 1. .00 46 .89 1SG1153
ATOM 1153 N GLY 149 156, .714 43 .228 1, .428 1. .00 46, .33 1SG1154
ATOM 1154 CA GLY 149 158, .010 43, .712 1, .822 1. .00 46, .33 1SG1155
ATOM 1155 C GLY 149 159, .025 42 .973 1, .002 1, .00 46, .33 1SG1156
ATOM 1156 O GLY 149 158, .692 42, .019 0, .304 1. .00 46, .33 1SG1157
ATOM 1157 N GLU 150 160 .299 43 .404 1, .099 1. .00 47 .56 1SG1158
ATOM 1158 CA GLU 150 161, .454 42, .873 0, .420 1. .00 47, .56 1SG1159
ATOM 1159 CB GLU 150 162, .726 43, .696 0. .688 1. .00 47, .56 1SG1160
ATOM 1160 CG GLU 150 163, .969 43 .161 -0. .027 1. .00 47, .56 1SG1161
ATOM 1161 CD GLU 150 165, .136 44, .072 0. .328 1. .00 47, .56 1SG1162
ATOM 1162 OEl GLU 150 164 .912 45 .050 1, .090 1. .00 47 .56 1SG1163
ATOM 1163 OE2 GLU 150 166, .266 43 .803 -0, .160 1. .00 47, .56 1SG1164
ATOM 1164 C GLU 150 161. .686 41, .494 0, .948 1. .00 47, .56 1SG1165
ATOM 1165 O GLU 150 162. .451 40 .703 0, .399 1. .00 47, .56 1SG1166
ATOM 1166 N LEU 151 161, .026 41, .231 2. .079 1. .00 49, .19 1SG1167
ATOM 1167 CA LEU 151 161, .029 40 .107 2, .965 1. .00 49, .19 1SG1168
ATOM 1168 CB LEU 151 160, .282 40, .393 4, .277 1. .00 49, .19 1SG1169
ATOM 1169 CG LEU 151 160, .941 41, .519 5. .096 1. .00 49. .19 1SG1170
ATOM 1170 CD2 LEU 151 160, .403 41 .560 6, .532 1. .00 49. .19 1SG1171
ATOM 1171 CDl LEU 151 160, .837 42, .873 4, .375 1. .00 49. .19 1SG1172
ATOM 1172 C LEU 151 160, .469 38 .846 2, .374 1. .00 49. .19 1SG1173
ATOM 1173 O LEU 151 160, .323 37 .868 3, .102 1. .00 49, .19 1SG1174
ATOM 1174 N SER 152 160, .083 38, .835 1. .084 1. .00 50. .22 1SG1175
ATOM 1175 CA SER 152 159, .355 37 .761 0. .448 1. .00 50. .22 1SG1176
ATOM 1176 CB SER 152 159, .403 37, .845 -1, .088 1. .00 50. .22 1SG1177
ATOM 1177 OG SER 152 158, .671 36 .768 -1, .656 1. .00 50. .22 1SG1178
ATOM 1178 C SER 152 159, .815 36, .372 0, .833 1. ,00 50. .22 1SG1179
ATOM 1179 O SER 152 159. .021 35, .438 0. .731 1. ,00 50. .22 1SG1180
ATOM 1180 N VAL 153 161. .066 36, .151 1. .284 1. ,00 49. .52 1SG1181
ATOM 1181 CA VAL 153 161. .441 34. .814 1. .679 1. 00 49. ,52 1SG1182 > > > > > > > > > > > > > > > > | > > > > > > > > > > > > > > > > > > > > 3=' > > > > > > H ^ H ^ H H H H H H H β H H H H H ι-3 ι^ H H H ^ H ^ H H H H ^ H H H H H H H H H H H ^ H H H H H >-3 H >^ ι-3 β H ι-- i-3 O P P P P P P P P P P P P P P P P P P P P O P P P P P P P P P P d d d d P P P P P P P P P d P P P P P P P P P P d 2 2 2 2 3 3 3 3 2 3 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2
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D t- D D i_) !D o 3 θ3 3 θ3 θ3 3 3 _ a a a a a a Ω D i-) Ω D D D a a a a a a D D D D D t_ D H H H H H H
B M M B B B >ι >< ι ι >ι ι ι >ι >ι W θl ι« ol ol θ) θl ϋl W H B B B B B B l oι o) θl cιl ffl cιl oι 1. J J J ι. h] J J j a B pq apq Bpq Bpq Bpq pq ω pq j l_i ιq j j j j j j j j j ι hQ (-i j j j ι-i j j ^ j ; < <; < o o u o o U o ε ■ — ε ε
H CD Ω Ω ft a CD Ω W -0 ft a CD Ω ft a CD Ω Ω ft a CD Ω ft ca o a a a PQ CD a u u u u u p a u u u u u a u p a U U U O u d a u u u u u u a u u u p u o a u u u u p p u p u u u oi u u p a
9 _0-
^o ^ lD m o ri f^ n ln ^o ^ o) Ol O ri M n <( ιn ^D oo Ol o ri (. n ^|| ιn ιo r- co ol O ri (. ι,l 'J' ln ^D r• !D Ol O ri cι ι>l '. ιn ^o ^ cD Λ O ri r^
01 01 IJ1 01 0 0 0 0 0 0 0 0 0 0 ri ri H ri ri ri ri ri H H l N I I N I M I I ri r. l . ri n n ffl r1 n ι. n ι(' '. * <li 'ji * ι|i '. ιf '. ιn in _
CN CN N CN co ro rO ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro ro r^ ri ri H ri H H ri ri ri ri ri H H H ri ri ri ri ri H H ri ri ri H H ri ri H H ri H H H H ri H H H H H ri ri ri ri ri H H ri H ri H ri ri ri ri ri ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε s ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε ε
PPPPPPPPPPPPPPPPPPPPPPPOPPPPOOPdOOPOPPOPOOOOPOOOOOOOOOOOO HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH f ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft ft fi ft ft ft i ft ft ft ft t ft t ft ft t ft t ft ft ft ft ^
ATOM 1353 CA LEU 174 134..499 27..179 12,.308 1..00 50..04 1SG1354
ATOM 1354 CB LEU 174 134. .400 27. .506 10, .805 1. .00 50, .04 1SG1355
ATOM 1355 CG LEU 174 134, .926 28. .900 10, .406 1. .00 50, .04 1SG1356
ATOM 1356 CD2 LEU 174 134, .657 29. .176 8, .917 1. .00 50, .04 1SG1357
ATOM 1357 CDl LEU 174 136, .397 29. .105 10. .786 1, .00 50, .04 1SG1358
ATOM 1358 C LEU 174 133, .504 26, .092 12. .595 1. .00 50, .04 1SG1359
ATOM 1359 O LEU 174 132, .432 26, .367 13, .130 1. .00 50, .04 1SG1360
ATOM 1360 N CYS 175 133, .830 24, .827 12, .269 1. .00 51, .69 1SG1361
ATOM 1361 CA CYS 175 132, .920 23, .737 12, .493 1. .00 51, .69 1SG1362
ATOM 1362 CB CYS 175 133, .510 22. .397 12, .022 1. .00 51, .69 1SG1363
ATOM 1363 SG CYS 175 132, .982 21, .838 10, .392 1. .00 51, .69 1SG1364
ATOM 1364 C CYS 175 132 .574 23 .625 13, .959 1. .00 51 .69 1SG1365
ATOM 1365 O CYS 175 131 .388 23 .540 14, .264 1. .00 51 .69 1SG1366
ATOM 1366 N PRO 176 133 .496 23, .571 14, .897 1, .00 50, .79 1SG1367
ATOM 1367 CA PRO 176 133 .028 23 .645 16, .243 1. .00 50 .79 1SG1368
ATOM 1368 CD PRO 176 134, .328 22, .380 14, .904 1, .00 50 .79 1SG1369
ATOM 1369 CB PRO 176 134, .226 23. .315 17, .133 1, .00 50 .79 1SG1370
ATOM 1370 CG PRO 176 135, .133 22, .479 16, .211 1. .00 50, .79 1SG1371
ATOM 1371 C PRO 176 132, .243 24, .838 16, .669 1. .00 50 .79 1SG1372
ATOM 1372 O PRO 176 131, .367 24, .657 17, .511 1. .00 50, .79 1SG1373
ATOM 1373 N ILE 177 132, .502 26, .054 16, .158 1, .00 46, .03 1SG1374
ATOM 1374 CA ILE 177 131, .636 27, .090 16, .639 1. .00 46, .03 1SG1375
ATOM 1375 CB ILE 177 131, .955 28. .489 16, .174 1. .00 46, .03 1SG1376
ATOM 1376 CG2 ILE 177 130, .678 29. .323 16, .371 1, .00 46, .03 1SG1377
ATOM 1377 CGI ILE 177 133, .172 29. .090 16, .905 1. .00 46, .03 1SG1378
ATOM 1378 CDl ILE 177 134, .524 28. .494 16, .536 1. .00 46, .03 1SG1379
ATOM 1379 C ILE 177 130 .239 26, .795 16, .192 1. .00 46 .03 1SG1380
ATOM 1380 O ILE 177 129 .299 26, .879 16, .980 1. .00 46 .03 1SG1381
ATOM 1381 N ILE 178 130 .069 26, .415 14, .912 1. .00 40 .84 1SG1382
ATOM 1382 CA ILE 178 128, .758 26, .200 14, .368 1, .00 40, .84 1SG1383
ATOM 1383 CB ILE 178 128, .782 25, .906 12, .885 1. .00 40, .84 1SG1384
ATOM 1384 CG2 ILE 178 129, .388 24 , .513 12, .659 1. .00 40, .84 1SG1385
ATOM 1385 CGI ILE 178 127, .390 26, .097 12. .249 1, .00 40. .84 1SG1386
ATOM 1386 CDl ILE 178 126, .312 25, .128 12. .734 1. .00 40. .84 1SG1387
ATOM 1387 C ILE 178 128, .065 25. .087 15. .096 1. .00 40, .84 1SG1388
ATOM 1388 O ILE 178 126, .896 25. .217 15. .454 1. .00 40. .84 1SG1389
ATOM 1389 N ALA 179 128, .759 23. .964 15. .354 1. .00 33. .49 1SG1390
ATOM 1390 CA ALA 179 128, .116 22. .852 15. .992 1. .00 33. .49 1SG1391
ATOM 1391 CB ALA 179 129, .046 21. .638 16. .154 1. .00 33. .49 1SG1392
ATOM 1392 C ALA 179 127. .657 23. .254 17. .358 1. ,00 33. .49 1SG1393
ATOM 1393 O ALA 179 126. .546 22. .920 17. .766 1. .00 33. .49 1SG1394
ATOM 1394 N SER 180 128. .508 23. .986 18, .100 1. .00 29. .20 1SG1395
ATOM 1395 CA SER 180 128, .194 24. .366 19, .449 1. .00 29. .20 1SG1396
ATOM 1396 CB SER 180 129, .362 25. .078 20, .151 1. .00 29, .20 1SG1397
ATOM 1397 OG SER 180 129, .625 26. .321 19, .517 1. .00 29, .20 1SG1398
ATOM 1398 C SER 180 127, .030 25. .306 19, .466 1. .00 29, .20 1SG1399
ATOM 1399 O SER 180 126, .145 25. .196 20. .313 1. .00 29. .20 1SG1400
ATOM 1400 N GLU 181 127, .001 26. .252 18. .512 1. .00 27. .57 1SG1401
ATOM 1401 CA GLU 181 125. .982 27. .260 18. .456 1. .00 27. .57 1SG1402
ATOM 1402 CB GLU 181 126. .199 28. .243 17. .295 1. .00 27. .57 1SG1403
ATOM 1403 CG GLU 181 127. .450 29. .106 17. .458 1. .00 27. .57 1SG1404
ATOM 1404 CD GLU 181 127. .640 29. .893 16. ,170 1. .00 27. ,57 1SG1405
ATOM 1405 OEl GLU 181 127. ,676 29. .249 15. ,088 1. .00 27. ,57 1SG1406
ATOM 1406 OE2 GLU 181 127. ,747 31. ,146 16. ,249 1. .00 27. ,57 1SG1407
ATOM 1407 C GLU 181 124. ,660 26. 598 18. ,246 1. ,00 27. ,57 1SG1408
ATOM 1408 O GLU 181 123. ,638 27. 062 18. ,748 1. 00 27. ,57 1SG1409
ATOM 1409 N VAL 182 124. .644 25. .487 17. .492 1. .00 28. .29 1SG1410 ATOM 1410 CA VAL 182 123..416 24,.806 17..210 1..00 28..29 1SG1411
ATOM 1411 CB VAL 182 123. .624 23, .545 16. .423 1. .00 28. .29 1SG1412
ATOM 1412 CGI VAL 182 122. .273 22 , .823 16. .281 1. .00 28. .29 1SG1413
ATOM 1413 CG2 VAL 182 124. .280 23, .912 15. .082 1. .00 28. .29 1SG1414
ATOM 1414 C VAL 182 122. .807 24. .430 18. .514 1. .00 28. .29 1SG1415
ATOM 1415 0 VAL 182 121. .594 24. .531 18. .694 1. .00 28. .29 1SG1416
ATOM 1416 N LYS 183 123. .648 24. .012 19. .474 1. .00 31. .66 1SG1417
ATOM 1417 CA LYS 183 123. .147 23. .635 20, .758 1. .00 31. .66 1SG1418
ATOM 1418 CB LYS 183 124. .268 23. .296 21, .758 1, .00 31, .66 1SG1419
ATOM 1419 CG LYS 183 125. .077 22, .047 21, .394 1. .00 31, . 66 1SG1420
ATOM 1420 CD LYS 183 126. .360 21, .890 22. .215 1. .00 31, .66 1SG1421
ATOM 1421 CE LYS 183 127. .120 20. .590 21. .939 1. .00 31. .66 1SG1422
ATOM 1422 NZ LYS 183 127. .946 20. .729 20. .719 1. .00 31. .66 1SG1423
ATOM 1423 C LYS 183 122. .411 24. .829 21. .293 1. .00 31. .66 1SG1424
ATOM 1424 0 LYS 183 121. .361 24. .691 21. .915 1. .00 31. .66 1SG1425
ATOM 1425 N ALA 184 122, .951 26. .041 21, .052 1. .00 33 .09 1SG1426
ATOM 1426 CA ALA 184 122, .336 27, .277 21, .456 1, .00 33. .09 1SG1427
ATOM 1427 CB ALA 184 123. .190 28, .507 21. .109 1. .00 33. .09 1SG1428
ATOM 1428 C ALA 184 121. .034 27, .413 20, .730 1. .00 33. .09 1SG1429
ATOM 1429 O ALA 184 120. .049 27, .899 21. .283 1, .00 33. .09 1SG1430
ATOM 1430 N LEU 185 121. .005 26, .993 19. .453 1. .00 33, .93 1SG1431
ATOM 1431 CA LEU 185 119. .822 27, .123 18. .655 1. .00 33, .93 1SG1432
ATOM 1432 CB LEU 185 120, .001 26, .570 17, .229 1 .00 33 .93 1SG1433
ATOM 1433 CG LEU 185 121, .054 27, .311 16, .389 1, .00 33 .93 1SG1434
ATOM 1434 CD2 LEU 185 120, .787 28, .824 16, .362 1, .00 33 .93 1SG1435
ATOM 1435 CDl LEU 185 121, .168 26, .699 14, .983 1, .00 33 .93 1SG1436
ATOM 1436 C LEU 185 118, .716 26, .322 19, .268 1, .00 33, .93 1SG1437
ATOM 1437 0 LEU 185 117. .585 26. .795 19, .367 1, .00 33, .93 1SG1438
ATOM 1438 N ASN 186 119. .012 25. .083 19. .703 1, .00 33, .07 1SG1439
ATOM 1439 CA ASN 186 117. .971 24. .236 20. .210 1. .00 33, .07 1SG1440
ATOM 1440 CB ASN 186 118, .404 22 .777 20 .472 1 .00 33 .07 1SG1441
ATOM 1441 CG ASN 186 119, .499 22. .714 21. .525 1, .00 33 .07 1SG1442
ATOM 1442 ODl ASN 186 119, .316 23 .086 22. .682 1, .00 33 .07 1SG1443
ATOM 1443 ND2 ASN 186 120, .688 22. .202 21, .108 1, .00 33 .07 1SG1444
ATOM 1444 C ASN 186 117, .378 24, .810 21, .457 1, .00 33 .07 1SG1445
ATOM 1445 O ASN 186 116, .170 24, .718 21, .668 1, .00 33, .07 1SG1446
ATOM 1446 N ALA 187 118. .203 25. .428 22. .318 1, .00 31, .81 1SG1447
ATOM 1447 CA ALA 187 117, .710 25 .949 23. .561 1 .00 31 .81 1SG1448
ATOM 1448 CB ALA 187 118, .815 26 .589 24. .417 1, .00 31 .81 1SG1449
ATOM 1449 C ALA 187 116, .682 27 .002 23. .285 1, .00 31 .81 1SG1450
ATOM 1450 O ALA 187 115, .679 27, .094 23. .991 1. .00 31, .81 1SG1451
ATOM 1451 N ASN 188 116, .916 27, .836 22. .256 1. .00 34, .22 1SG1452
ATOM 1452 CA ASN 188 116, .029 28, .912 21. .924 1, .00 34, .22 1SG1453
ATOM 1453 CB ASN 188 116. .561 29, .748 20. .747 1, .00 34. .22 1SG1454
ATOM 1454 CG ASN 188 115. .622 30, .922 20. .520 1. .00 34, .22 1SG1455
ATOM 1455 ODl ASN 188 115, .461 31 .782 21, .383 1. .00 34 .22 1SG1456
ATOM 1456 ND2 ASN 188 114. .989 30, .964 19. .317 1, .00 34. .22 1SG1457
ATOM 1457 C ASN 188 114. .691 28, .363 21, .525 1, .00 34. .22 1SG1458
ATOM 1458 0 ASN 188 113. .650 28, .836 21, .971 1, .00 34, .22 1SG1459
ATOM 1459 N LEU 189 114. .690 27, .318 20, .686 1. .00 39, .41 1SG1460
ATOM 1460 CA LEU 189 113. .496 26. .718 20. .163 1. .00 39, .41 1SG1461
ATOM 1461 CB LEU 189 113. .777 25. .632 19. .111 1. .00 39. .41 1SG1462
ATOM 1462 CG LEU 189 114, .417 26. .192 17, .826 1, .00 39. .41 1SG1463
ATOM 1463 CD2 LEU 189 113, .635 27, .404 17. .295 1, .00 39. .41 1SG1464
ATOM 1464 CDl LEU 189 114, .602 25, .093 16. .768 1. .00 39. .41 1SG1465
ATOM 1465 C LEU 189 112. .701 26. .107 21. .276 1. .00 39, .41 1SG1466
ATOM 1466 0 LEU 189 111. .499 25. .898 21. ,142 1. .00 39, .41 1SG1467 ATOM 1467 N SER 190 113..369 25,.734 22.379 1..00 46,.01 1SG1468
ATOM 1468 CA SER 190 112, .744 25, .112 23, .513 1, .00 46, .01 1SG1469
ATOM 1469 CB SER 190 113, .761 24. .504 24 .494 1. .00 46, .01 1SG1470
ATOM 1470 OG SER 190 114, .459 23, .436 23 .870 1, .00 46, .01 1SG1471
ATOM 1471 C SER 190 111, .932 26, .121 24 .265 1. .00 46, .01 1SG1472
ATOM 1472 O SER 190 111 .286 25 .787 25 .256 1 .00 46, .01 1SG1473
ATOM 1473 N THR 191 111 .975 27 .391 23 .830 1 .00 52 .62 1SG1474
ATOM 1474 CA THR 191 111 .251 28 .457 24 .455 1 .00 52 .62 1SG1475
ATOM 1475 CB THR 191 111 .605 29, .809 23 .921 1. .00 52, .62 1SG1476
ATOM 1476 OGl THR 191 112 .983 30, .076 24 .128 1, .00 52 .62 1SG1477
ATOM 1477 CG2 THR 191 110 .755 30, .847 24 .665 1, .00 52, .62 1SG1478
ATOM 1478 C THR 191 109 .786 28, .259 24 .230 1. .00 52, .62 1SG1479
ATOM 1479 O THR 191 108 .966 28, .787 24 .980 1, .00 52, .62 1SG1480
ATOM 1480 N LEU 192 109 .414 27, .528 23 .159 1, .00 56, .59 1SG1481
ATOM 1481 CA LEU 192 108 .024 27. .352 22, .847 1, .00 56, .59 1SG1482
ATOM 1482 CB LEU 192 107, .733 26. .427 21, .652 1. .00 56, .59 1SG1483
ATOM 1483 CG LEU 192 107. .991 27, .057 20, .276 1. .00 56, .59 1SG1484
ATOM 1484 CD2 LEU 192 107 .445 26 .166 19 .148 1. .00 56 .59 1SG1485
ATOM 1485 CDl LEU 192 109 .470 27, .407 20 .087 1. .00 56 .59 1SG1486
ATOM 1486 C LEU 192 107 .299 26, .766 24 .018 1. .00 56 .59 1SG1487
ATOM 1487 O LEU 192 107 .810 25, .896 24 .719 1. .00 56 .59 1SG1488
ATOM 1488 N GLU 193 106 .066 27, .261 24 .266 1, .00 56, .97 1SG1489
ATOM 1489 CA GLU 193 105 .333 26, .789 25 .406 1. .00 56, .97 1SG1490
ATOM 1490 CB GLU 193 104. .238 27, .754 25 .887 1. .00 56, .97 1SG1491
ATOM 1491 CG GLU 193 104 .818 28, .899 26, .714 1. .00 56, .97 1SG1492
ATOM 1492 CD GLU 193 105. .376 28, .265 27, .982 1. .00 56, .97 1SG1493
ATOM 1493 OEl GLU 193 104, .566 27, .699 28, .765 1. .00 56, .97 1SG1494
ATOM 1494 OE2 GLU 193 106, .619 28. .324 28. .178 1. .00 56, .97 1SG1495
ATOM 1495 C GLU 193 104 .706 25, .456 25 .146 1. .00 56 .97 1SG1496
ATOM 1496 O GLU 193 104 .002 25, .265 24 .156 1. .00 56 .97 1SG1497
ATOM 1497 N VAL 194 105 .032 24, .475 26 .018 1. .00 55, .73 1SG1498
ATOM 1498 CA VAL 194 104 .454 23 , .160 26 .011 1. .00 55, .73 1SG1499
ATOM 1499 CB VAL 194 105 .283 22, .188 26 .801 1. .00 55, .73 1SG1500
ATOM 1500 CGI VAL 194 104 .616 20. .803 26, .759 1. .00 55, .73 1SG1501
ATOM 1501 CG2 VAL 194 106, .724 22. .221 26, .270 1. .00 55, .73 1SG1502
ATOM 1502 C VAL 194 103, .113 23. .195 26, .679 1. .00 55, .73 1SG1503
ATOM 1503 O VAL 194 102, .084 22. .856 26, .095 1. .00 55. .73 1SG1504
ATOM 1504 N LEU 195 103, .117 23. .640 27, .953 1. .00 57. .01 1SG1505
ATOM 1505 CA LEU 195 101, .911 23. .730 28, .723 1. .00 57. .01 1SG1506
ATOM 1506 CB LEU 195 101 .943 23, .061 30 .119 1. .00 57. .01 1SG1507
ATOM 1507 CG LEU 195 102 .114 21, .531 30, .174 1. .00 57. .01 1SG1508
ATOM 1508 CD2 LEU 195 101, .767 20. .992 31, .574 1. .00 57. .01 1SG1509
ATOM 1509 CDl LEU 195 103, .512 21. .097 29, .707 1. .00 57. .01 1SG1510
ATOM 1510 C LEU 195 101, .742 25. .180 29, .006 1. .00 57. .01 1SG1511
ATOM 1511 0 LEU 195 102, .445 25. .746 29. .842 1. .00 57. .01 1SG1512
ATOM 1512 N THR 196 100, .782 25. .822 28. .326 1. .00 60. ,96 1SG1513
ATOM 1513 CA THR 196 100, .605 27. .219 28. .561 1. .00 60. ,96 1SG1514
ATOM 1514 CB THR 196 100. .193 27. .961 27. .325 1. .00 60. ,96 1SG1515
ATOM 1515 OGl THR 196 101. .170 27. .786 26. .309 1. .00 60. ,96 1SG1516
ATOM 1516 CG2 THR 196 100. .032 29. .451 27. .667 1. .00 60. ,96 1SG1517
ATOM 1517 C THR 196 99. ,495 27. .365 29. .550 1. ,00 60. ,96 1SG1518
ATOM 1518 0 THR 196 98, .354 27. .005 29. .270 1. ,00 60. ,96 1SG1519
ATOM 1519 N LYS 197 99, .821 27. .896 30. .745 1. ,00 65. ,54 1SG1520
ATOM 1520 CA LYS 197 98. .839 28. .090 31. .773 1. .00 65. ,54 1SG1521
ATOM 1521 CB LYS 197 99. .437 28. .059 33. .191 1. .00 65. ,54 1SG1522
ATOM 1522 CG LYS 197 98. .418 28. .285 34. .315 1. 00 65. ,54 1SG1523
ATOM 1523 CD LYS 197 98. ,970 28. .003 35. .718 1. 00 65. 54 1SG1524 ATOM 1524 CE LYS 197 97..994 28,.304 36..863 1..00 65..54 1SG1525
ATOM 1525 NZ LYS 197 97. .786 29, .765 36. .999 1. .00 65. .54 1SG1526
ATOM 1526 C LYS 197 98. .274 29 .449 31. .553 1. .00 65. .54 1SG1527
ATOM 1527 O LYS 197 98, .941 30, .457 31. .776 1. .00 65. .54 1SG1528
ATOM 1528 N ILE 198 97, .040 29, .484 31. .024 1. .00 71. .32 1SG1529
ATOM 1529 CA ILE 198 96, .354 30 .698 30. .719 1, .00 71. .32 1SG1530
ATOM 1530 CB ILE 198 95, .206 30 .465 29, .783 1. .00 71. .32 1SG1531
ATOM 1531 CG2 ILE 198 94, .786 31 .844 29, .271 1. .00 71. .32 1SG1532
ATOM 1532 CGI ILE 198 95, .626 29, .568 28. .609 1. .00 71. .32 1SG1533
ATOM 1533 CDl ILE 198 94 .450 29 .059 27. .776 1. .00 71. .32 1SG1534
ATOM 1534 C ILE 198 95, .814 31, .315 31, .963 1, .00 71. .32 1SG1535
ATOM 1535 O ILE 198 95, .866 32, .530 32, .151 1. .00 71. .32 1SG1536
ATOM 1536 N ASP 199 95, .240 30, .470 32. .838 1. .00 71. .92 1SG1537
ATOM 1537 CA ASP 199 94, .547 31 .000 33. .966 1 .00 71, .92 1SG1538
ATOM 1538 CB ASP 199 93, .050 31 .076 33, .636 1, .00 71. .92 1SG1539
ATOM 1539 CG ASP 199 92, .354 32 .039 34 , .564 1. .00 71, .92 1SG1540
ATOM 1540 ODl ASP 199 92, .935 33 .122 34. .834 1. .00 71, .92 1SG1541
ATOM 1541 OD2 ASP 199 91, .214 31 .716 34. .987 1 .00 71 .92 1SG1542
ATOM 1542 C ASP 199 94. .702 30 .048 35, .110 1. .00 71, .92 1SG1543
ATOM 1543 O ASP 199 95. .523 29 .132 35, .101 1. .00 71, .92 1SG1544
ATOM 1544 N ASN 200 93 .901 30 .292 36 .161 1 .00 66 .48 1SG1545
ATOM 1545 CA ASN 200 93. .820 29 .469 37, .324 1 .00 66 .48 1SG1546
ATOM 1546 CB ASN 200 93. .160 30 .167 38, .531 1 .00 66 .48 1SG1547
ATOM 1547 CG ASN 200 91. .833 30, .805 38, .155 1. .00 66 .48 1SG1548
ATOM 1548 ODl ASN 200 91. .478 31 .832 38 .732 1 .00 66 .48 1SG1549
ATOM 1549 ND2 ASN 200 91. .089 30 .207 37 .188 1 .00 66 .48 1SG1550
ATOM 1550 C ASN 200 93, .121 28 .191 36. .976 1 .00 66 .48 1SG1551
ATOM 1551 O ASN 200 93. .235 27. .202 37, .697 1, .00 66, .48 1SG1552
ATOM 1552 N TYR 201 92 .350 28 .158 35 .868 1 .00 62 .39 1SG1553
ATOM 1553 CA TYR 201 91, .671 26 .916 35 .690 1 .00 62 .39 1SG1554
ATOM 1554 CB TYR 201 90. .171 27 .056 35, .402 1, .00 62, .39 1SG1555
ATOM 1555 CG TYR 201 89. .584 25. .901 36, .141 1, .00 62, .39 1SG1556
ATOM 1556 CDl TYR 201 89. .727 24 .591 35 .737 1 .00 62 .39 1SG1557
ATOM 1557 CD2 TYR 201 88, .883 26 .163 37, .293 1, .00 62 .39 1SG1558
ATOM 1558 CE1 TYR 201 89, .170 23. .572 36, .482 1, .00 62, .39 1SG1559
ATOM 1559 CE2 TYR 201 88. .325 25 .156 38 .037 1, .00 62 .39 1SG1560
ATOM 1560 CZ TYR 201 88, .468 23 .855 37, .631 1 .00 62 .39 1SG1561
ATOM 1561 OH TYR 201 87, .891 22 .828 38, .408 1 .00 62, .39 1SG1562
ATOM 1562 C TYR 201 92. .268 26. .167 34, .526 1, .00 62, .39 1SG1563
ATOM 1563 O TYR 201 92, .699 25 .031 34 .699 1 .00 62 .39 1SG1564
ATOM 1564 N THR 202 92, .310 26 .767 33, .313 1, .00 57, .51 1SG1565
ATOM 1565 CA THR 202 92. .767 26, .052 32, .145 1, .00 57, .51 1SG1566
ATOM 1566 CB THR 202 91. .912 26, .344 30, .941 1. .00 57, .51 1SG1567
ATOM 1567 OGl THR 202 92. .244 25 .487 29, .859 1, .00 57, .51 1SG1568
ATOM 1568 CG2 THR 202 92. .094 27, .815 30, .535 1, .00 57, .51 1SG1569
ATOM 1569 C THR 202 94. .209 26, .323 31, .782 1. .00 57, .51 1SG1570
ATOM 1570 O THR 202 94. .862 27. .227 32. .302 1. .00 57. .51 1SG1571
ATOM 1571 N LEU 203 94. .706 25. .468 30, .852 1. .00 56, .65 1SG1572
ATOM 1572 CA LEU 203 96. .020 25. .389 30, .258 1. .00 56, .65 1SG1573
ATOM 1573 CB LEU 203 96. ,820 24. .179 30. .767 1. .00 56. .65 1SG1574
ATOM 1574 CG LEU 203 91 . ,288 24. .216 32. .226 1. .00 56. .65 1SG1575
ATOM 1575 CD2 LEU 203 98. .412 25. .245 32. .416 1. .00 56. .65 1SG1576
ATOM 1576 CDl LEU 203 97. .752 22. .817 32. .655 1. .00 56. .65 1SG1577
ATOM 1577 C LEU 203 95. ,795 25. .013 28. .824 1. .00 56. .65 1SG1578
ATOM 1578 O LEU 203 94. .722 24. .529 28. .466 1. .00 56. .65 1SG1579
ATOM 1579 N LEU 204 96. .815 25. .216 27. .961 1. .00 60. .25 1SG1580
ATOM 1580 CA LEU 204 96. ,700 24. .800 26. .590 1. .00 60. ,25 1SG1581 ATOM 1581 CB LEU 204 96..795 25,.977 25..604 1..00 60..25 1SG1582
ATOM 1582 CG LEU 204 96. .252 25, .658 24. .202 1. .00 60. .25 1SG1583
ATOM 1583 CD2 LEU 204 94. .743 25 .371 24, .279 1. .00 60. .25 1SG1584
ATOM 1584 CDl LEU 204 97. .050 24, .544 23. .511 1. .00 60. .25 1SG1585
ATOM 1585 C LEU 204 97. .880 23, .906 26, .350 1. .00 60. .25 1SG1586
ATOM 1586 O LEU 204 98. .987 24 .202 26, .799 1. .00 60. .25 1SG1587
ATOM 1587 N ASP 205 97, .684 22 .772 25 .641 1, .00 62, .65 1SG1588
ATOM 1588 CA ASP 205 98. .752 21, .833 25, .439 1. .00 62. .65 1SG1589
ATOM 1589 CB ASP 205 98. .287 20 .389 25, .701 1. .00 62, .65 1SG1590
ATOM 1590 CG ASP 205 99. .466 19 .429 25, .682 1. .00 62, .65 1SG1591
ATOM 1591 ODl ASP 205 100, .526 19 .770 25 .093 1. .00 62, .65 1SG1592
ATOM 1592 OD2 ASP 205 99. .314 18, .321 26, .262 1. .00 62. .65 1SG1593
ATOM 1593 C ASP 205 99. .262 21, .944 24, .024 1. .00 62. .65 1SG1594
ATOM 1594 O ASP 205 98, .663 21 .436 23, .080 1. .00 62, .65 1SG1595
ATOM 1595 N TYR 206 100, .386 22 .667 23, .881 1. .00 65, .18 1SG1596
ATOM 1596 CA TYR 206 101. .182 22, .928 22. .715 1. .00 65. .18 1SG1597
ATOM 1597 CB TYR 206 101. .862 24, .314 22, .672 1. .00 65. .18 1SG1598
ATOM 1598 CG TYR 206 100, .753 25 .244 22, .292 1. .00 65, .18 1SG1599
ATOM 1599 CDl TYR 206 100, .198 25 .142 21, .037 1, .00 65 .18 1SG1600
ATOM 1600 CD2 TYR 206 100. .280 26, .210 23. .152 1. .00 65, .18 1SG1601
ATOM 1601 CE1 TYR 206 99. .175 25, .973 20. .647 1. .00 65, .18 1SG1602
ATOM 1602 CE2 TYR 206 99. .253 27 .044 22, .770 1, .00 65, .18 1SG1603
ATOM 1603 CZ TYR 206 98. .699 26 .925 21 .519 1, .00 65 .18 1SG1604
ATOM 1604 OH TYR 206 97. .649 27, .774 21, .123 1. .00 65. .18 1SG1605
ATOM 1605 C TYR 206 102. .147 21, .827 22, .351 1. .00 65. .18 1SG1606
ATOM 1606 O TYR 206 102. .871 21 .969 21, .369 1, .00 65. .18 1SG1607
ATOM 1607 N SER 207 102. .323 20 .789 23 .196 1. .00 63. .05 1SG1608
ATOM 1608 CA SER 207 103. .348 19, .794 22, .954 1. .00 63. .05 1SG1609
ATOM 1609 CB SER 207 103 , .384 18 .637 23, .976 1. .00 63. .05 1SG1610
ATOM 1610 OG SER 207 104, .450 17 .749 23, .664 1. .00 63. .05 1SG1611
ATOM 1611 C SER 207 103, .278 19 .180 21 .585 1, .00 63. .05 1SG1612
ATOM 1612 0 SER 207 102. .209 18, .923 21, .032 1. .00 63. .05 1SG1613
ATOM 1613 N LEU 208 104. .478 18, .939 21, .005 1. .00 58. .44 1SG1614
ATOM 1614 CA LEU 208 104. .600 18, .362 19, .695 1. .00 58, .44 1SG1615
ATOM 1615 CB LEU 208 106. .003 18 .494 19, .074 1, .00 58, .44 1SG1616
ATOM 1616 CG LEU 208 106. .401 19 .934 18, .696 1. .00 58, .44 1SG1617
ATOM 1617 CD2 LEU 208 107. .705 19, .951 17. .880 1. .00 58. .44 1SG1618
ATOM 1618 CDl LEU 208 106. .469 20, .844 19, .931 1, .00 58, .44 1SG1619
ATOM 1619 C LEU 208 104. .273 16, .908 19, .777 1, .00 58, .44 1SG1620
ATOM 1620 0 LEU 208 104, .789 16 .192 20 .632 1. .00 58, .44 1SG1621
ATOM 1621 N ILE 209 103. .351 16, .462 18, .902 1. .00 53. .29 1SG1622
ATOM 1622 CA ILE 209 102. .914 15, .100 18, .777 1. .00 53. .29 1SG1623
ATOM 1623 CB ILE 209 101. .579 14, .960 18, .103 1. .00 53. .29 1SG1624
ATOM 1624 CG2 ILE 209 101, .336 13, .470 17, .809 1. .00 53. .29 1SG1625
ATOM 1625 CGI ILE 209 100. .487 15, .600 18. .979 1. .00 53. .29 1SG1626
ATOM 1626 CDl ILE 209 99. .116 15, .662 18. .308 1. .00 53. .29 1SG1627
ATOM 1627 C ILE 209 103 , .912 14, .247 18, .063 1. .00 53. .29 1SG1628
ATOM 1628 0 ILE 209 104. .000 13, .054 18, .340 1. .00 53. .29 1SG1629
ATOM 1629 N SER 210 104. .627 14. .805 17. .062 1. .00 45. .81 1SG1630
ATOM 1630 CA SER 210 105. .568 14 , .011 16. .316 1. .00 45. .81 1SG1631
ATOM 1631 CB SER 210 104. .989 13, .450 15. .002 1. .00 45. .81 1SG1632
ATOM 1632 OG SER 210 105. .960 12, .670 14. .317 1. .00 45. .81 1SG1633
ATOM 1633 C SER 210 106. .732 14. .889 15. .962 1. ,00 45. ,81 1SG1634
ATOM 1634 0 SER 210 106. .726 16. .089 16. .230 1. ,00 45. .81 1SG1635
ATOM 1635 N SER 211 107. .782 14. .298 15. .356 1. .00 40. .79 1SG1636
ATOM 1636 CA SER 211 108. .946 15, .058 15. .004 1. .00 40. .79 1SG1637
ATOM 1637 CB SER 211 110. ,145 14. .190 14. ,587 1. .00 40. .79 1SG1638 O H CN ro -. in vo t-- oo cn o ri CN ro ^ in vD [-- oo en o ri cN ro ^ in vD t-- eD cn o ri CN cn ^ in iD i~ CD cn o ri cN ro ^ in o r- oo on o ri cN ro ^ in ^ ^tι ^ ^ ^ ^ ^ ^ ^ ^ ιιnn ιιnn ιιnn ιιnn ιιn ιιnn ιιnn mm ιιn ιιnn vιoo vvDo iιDo vvoo viDD ωω vιoo vvoo voo vvoo tι^^ tt^^ rr~- rr^^ tt^-- tr~- tc^^ cc^^ rr-- ααD3 oCDo cCDo ccoo ccoo ∞oo coDo CcDD CoDo CoDo cσ σσ cnn ccnn σσι men
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ATOM 1695 CE1 TYR 218 104..934 21,.851 1,.372 1..00 50..08 1SG1696
ATOM 1696 CE2 TYR 218 104. .600 20, .519 3 .309 1. .00 50. .08 1SG1697
ATOM 1697 CZ TYR 218 104. .537 20 .669 1 .944 1. .00 50. .08 1SG1698
ATOM 1698 OH TYR 218 104. .069 19 .615 1 .131 1, .00 50 .08 1SG1699
ATOM 1699 C TYR 218 108. .025 22, .944 5, .413 1. .00 50. .08 1SG1700
ATOM 1700 O TYR 218 108. .261 21 .756 5, .200 1. .00 50. .08 1SG1701
ATOM 1701 N LEU 219 108, .224 23 .512 6 .622 1, .00 49 .88 1SG1702
ATOM 1702 CA LEU 219 108 .642 22 .724 7. .747 1 .00 49 .88 1SG1703
ATOM 1703 CB LEU 219 109 .656 23 .437 8 .656 1 .00 49 .88 1SG1704
ATOM 1704 CG LEU 219 110, .353 22, .560 9 .717 1, .00 49. .88 1SG1705
ATOM 1705 CD2 LEU 219 109, .465 21, .440 10 .269 1, .00 49. .88 1SG1706
ATOM 1706 CDl LEU 219 110, .963 23 .438 10 .816 1, .00 49 .88 1SG1707
ATOM 1707 C LEU 219 107 .378 22 .584 8 .538 1 .00 49 .88 1SG1708
ATOM 1708 O LEU 219 106. .795 23, .581 8 .961 1. .00 49. .88 1SG1709
ATOM 1709 N ASP 220 106, .905 21, .342 8 .750 1, .00 46. .84 1SG1710
ATOM 1710 CA ASP 220 105. .641 21, .191 9 .412 1. .00 46, .84 1SG1711
ATOM 1711 CB ASP 220 104, .711 20 .183 8 .712 1, .00 46 .84 1SG1712
ATOM 1712 CG ASP 220 104 .308 20 .759 7 .356 1 .00 46 .84 1SG1713
ATOM 1713 ODl ASP 220 104 , .691 21, .924 7, .065 1, .00 46, .84 1SG1714
ATOM 1714 OD2 ASP 220 103. .610 20, .039 6 .594 1, .00 46 .84 1SG1715
ATOM 1715 C ASP 220 105, .835 20 .734 10 .828 1, .00 46 .84 1SG1716
ATOM 1716 O ASP 220 106, .562 19 .779 11 .095 1 .00 46 .84 1SG1717
ATOM 1717 N LEU 221 105 .178 21 .434 11 .779 1 .00 44 .50 1SG1718
ATOM 1718 CA LEU 221 105. .244 21, .073 13, .169 1, .00 44, .50 1SG1719
ATOM 1719 CB LEU 221 105, .772 22, .198 14 .078 1, .00 44, .50 1SG1720
ATOM 1720 CG LEU 221 107, .248 22 .563 13 .823 1, .00 44 .50 1SG1721
ATOM 1721 CD2 LEU 221 107, .800 23 .475 14 .931 1. .00 44 .50 1SG1722
ATOM 1722 CDl LEU 221 107. .447 23, .141 12, .412 1. .00 44, .50 1SG1723
ATOM 1723 C LEU 221 103. .854 20, .735 13 .625 1, .00 44, .50 1SG1724
ATOM 1724 O LEU 221 102. .913 21, .503 13 .424 1, .00 44, .50 1SG1725
ATOM 1725 N ASN 222 103. .692 19 .559 14 .267 1. .00 41 .14 1SG1726
ATOM 1726 CA ASN 222 102, .393 19 .137 14 .711 1, .00 41 .14 1SG1727
ATOM 1727 CB ASN 222 102 , .094 17, .671 14, .373 1. .00 41, .14 1SG1728
ATOM 1728 CG ASN 222 102, .101 17, .569 12, .855 1. .00 41, .14 1SG1729
ATOM 1729 ODl ASN 222 103, .162 17, .571 12 .233 1. .00 41, .14 1SG1730
ATOM 1730 ND2 ASN 222 100, .891 17, .484 12 .240 1. .00 41, .14 1SG1731
ATOM 1731 C ASN 222 102, .335 19, .290 16, .198 1. .00 41, .14 1SG1732
ATOM 1732 O ASN 222 103. .265 18, .918 16, .911 1. .00 41, .14 1SG1733
ATOM 1733 N LEU 223 101. .220 19, .865 16, .697 1. .00 40, .78 1SG1734
ATOM 1734 CA LEU 223 101. .084 20. .121 18, .105 1, .00 40, .78 1SG1735
ATOM 1735 CB LEU 223 100. .999 21. .623 18, .399 1, .00 40, .78 1SG1736
ATOM 1736 CG LEU 223 102. .067 22. .445 17. .650 1. .00 40. .78 1SG1737
ATOM 1737 CD2 LEU 223 103. .478 21. .871 17. .841 1. .00 40. .78 1SG1738
ATOM 1738 CDl LEU 223 101. .957 23. .939 17, .987 1. .00 40. .78 1SG1739
ATOM 1739 C LEU 223 99. .770 19, .527 18, .541 1. .00 40. .78 1SG1740
ATOM 1740 O LEU 223 98. .864 19. .358 17. .728 1. .00 40. ,78 1SG1741
ATOM 1741 N LYS 224 99. .641 19. .169 19. .839 1. ,00 43. ,95 1SG1742
ATOM 1742 CA LYS 224 98. .420 18. .588 20. .344 1. .00 43. .95 1SG1743
ATOM 1743 CB LYS 224 98. .543 18. .067 21. .784 1. .00 43. .95 1SG1744
ATOM 1744 CG LYS 224 99. .324 16. .755 21, .866 1. .00 43. .95 1SG1745
ATOM 1745 CD LYS 224 99. ,694 16. ,349 23. .291 1. .00 43. .95 1SG1746
ATOM 1746 CE LYS 224 98. ,523 16. .503 24. .259 1. ,00 43. ,95 1SG1747
ATOM 1747 NZ LYS 224 97. .313 15. .880 23. .679 1. ,00 43. ,95 1SG1748
ATOM 1748 C LYS 224 97. .277 19. .569 20. .280 1. ,00 43. ,95 1SG1749
ATOM 1749 O LYS 224 96. .212 19. .245 19. .757 1. 00 43. 95 1SG1750
ATOM 1750 N GLY 225 97. .465 20. ,800 20. ,798 1. 00 49. 62 1SG1751
ATOM 1751 CA GLY 225 96. .474 21. ,843 20. ,682 1. 00 49. ,62 1SG1752 ATOM 1752 C GLY 225 95.,172 21.,523 21..362 1.,00 49..62 1SG1753
ATOM 1753 O GLY 225 94. ,124 21. ,530 20. .715 1. ,00 49. .62 1SG1754
ATOM 1754 N VAL 226 95. .188 21. .234 22. .680 1. .00 57. .21 1SG1755
ATOM 1755 CA VAL 226 93. .956 20. .964 23 .370 1, .00 57. .21 1SG1756
ATOM 1756 CB VAL 226 93. ,841 19. ,516 23. .767 1. .00 57. .21 1SG1757
ATOM 1757 CGI VAL 226 93. .966 18. .670 22. .494 1. .00 57. .21 1SG1758
ATOM 1758 CG2 VAL 226 94. .920 19. .164 24. .806 1. .00 57. .21 1SG1759
ATOM 1759 C VAL 226 93. .978 21. .755 24. .647 1, .00 57. .21 1SG1760
ATOM 1760 O VAL 226 95. .018 21. .855 25 .294 1, .00 57, .21 1SG1761
ATOM 1761 N PHE 227 92. .836 22. .352 25, .056 1. .00 63. .53 1SG1762
ATOM 1762 CA PHE 227 92. .824 22. .998 26 .342 1. .00 63. .53 1SG1763
ATOM 1763 CB PHE 227 91. .623 23. .927 26, .607 1. .00 63. .53 1SG1764
ATOM 1764 CG PHE 227 91. .808 25. .240 25 .919 1. .00 63. .53 1SG1765
ATOM 1765 CDl PHE 227 91. .593 25. .364 24, .567 1. .00 63. .53 1SG1766
ATOM 1766 CD2 PHE 227 92. .171 26. .360 26. .637 1. .00 63. .53 1SG1767
ATOM 1767 CE1 PHE 227 91. .752 26. .579 23 .944 1. .00 63. .53 1SG1768
ATOM 1768 CE2 PHE 227 92, .331 27. .576 26 .016 1, .00 63, .53 1SG1769
ATOM 1769 CZ PHE 227 92, .123 27, .690 24 .663 1, .00 63, .53 1SG1770
ATOM 1770 C PHE 227 92. .767 21. .880 27. .336 1. .00 63, .53 1SG1771
ATOM 1771 O PHE 227 92. .164 20. .840 27 .070 1. .00 63, .53 1SG1772
ATOM 1772 N TYR 228 93, .418 22. .067 28 .502 1. .00 67, .99 1SG1773
ATOM 1773 CA TYR 228 93. .587 20. .986 29 .428 1. .00 67, .99 1SG1774
ATOM 1774 CB TYR 228 95. .096 20. .680 29 .455 1. .00 67, .99 1SG1775
ATOM 1775 CG TYR 228 95, .386 19, .235 29 .581 1. .00 67, .99 1SG1776
ATOM 1776 CDl TYR 228 95 .510 18, .624 30 .807 1 .00 6 .99 1SG1777
ATOM 1777 CD2 TYR 228 95. .534 18. .505 28. .427 1. .00 67. .99 1SG1778
ATOM 1778 CE1 TYR 228 95, .794 17. .282 30 .889 1. .00 67. .99 1SG1779
ATOM 1779 CE2 TYR 228 95 .812 17. .167 28 .505 1 .00 67 .99 1SG1780
ATOM 1780 CZ TYR 228 95, .940 16. .556 29 .728 1, .00 67 .99 1SG1781
ATOM 1781 OH TYR 228 96, .234 15. .180 29 .766 1 .00 67 .99 1SG1782
ATOM 1782 C TYR 228 93, .211 21. .498 30 .795 1. .00 67. .99 1SG1783
ATOM 1783 O TYR 228 93 .492 22. .645 31 .125 1 .00 67. .99 1SG1784
ATOM 1784 N PRO 229 92, .472 20. .732 31 .555 1. .00 63, .94 1SG1785
ATOM 1785 CA PRO 229 92, .261 21. .104 32 .941 1 .00 63 .94 1SG1786
ATOM 1786 CD PRO 229 91. .271 20. .169 30 .960 1 .00 63, .94 1SG1787
ATOM 1787 CB PRO 229 90, .810 20. .748 33 .264 1, .00 63, .94 1SG1788
ATOM 1788 CG PRO 229 90 .396 19. .768 32 .151 1 .00 63 .94 1SG1789
ATOM 1789 C PRO 229 93, .252 20. .430 33 .856 1, .00 63, .94 1SG1790
ATOM 1790 O PRO 229 93, .507 19. ,242 33 .662 1, .00 63, .94 1SG1791
ATOM 1791 N LEU 230 93, .816 21, .135 34 .864 1 .00 59, .00 1SG1792
ATOM 1792 CA LEU 230 94, .707 20, .473 35 .784 1, .00 59, .00 1SG1793
ATOM 1793 CB LEU 230 95 .555 21, .425 36 .645 1 .00 59 .00 1SG1794
ATOM 1794 CG LEU 230 96, .491 20. .649 37. .599 1, .00 59. .00 1SG1795
ATOM 1795 CD2 LEU 230 97, .188 21, .572 38. .611 1, .00 59. .00 1SG1796
ATOM 1796 CDl LEU 230 97, .493 19, .788 36. .811 1, .00 59. .00 1SG1797
ATOM 1797 C LEU 230 93 .957 19, .616 36 .757 1, .00 59, .00 1SG1798
ATOM 1798 O LEU 230 94. .294 18. .450 36 .957 1, .00 59 .00 1SG1799
ATOM 1799 N GLU 231 92. .918 20. .189 37, .403 1, .00 53. .06 1SG1800
ATOM 1800 CA GLU 231 92 .250 19. .481 38 .457 1, .00 53. .06 1SG1801
ATOM 1801 CB GLU 231 91. .389 20. .349 39 .389 1, .00 53. .06 1SG1802
ATOM 1802 CG GLU 231 92, .206 20. .951 40 .540 1 .00 53. .06 1SG1803
ATOM 1803 CD GLU 231 92. .703 19. .809 41. .432 1. .00 53. .06 1SG1804
ATOM 1804 OEl GLU 231 93. .445 18. .925 40. .921 1, .00 53. .06 1SG1805
ATOM 1805 OE2 GLU 231 92 .353 19. .811 4 .643 1. .00 53. .06 1SG1806
ATOM 1806 C GLU 231 91. .455 18. .304 38, .002 1, .00 53. .06 1SG1807
ATOM 1807 O GLU 231 91, .482 17. .265 38, .655 1. .00 53. .06 1SG1808
ATOM 1808 N ASN 232 90. .711 18. ,407 36. .889 1. .00 47. ,01 1SG1809 ATOM 1809 CA ASN 232 89,.945 17.251 36..528 1..00 47,.01 1SG1810
ATOM 1810 CB ASN 232 88, .434 17 .493 36, .711 1, .00 47, .01 1SG1811
ATOM 1811 CG ASN 232 87 .717 16 .174 36, .963 1 .00 47 .01 1SG1812
ATOM 1812 ODl ASN 232 88, .242 15 .091 36, .717 1, .00 47, .01 1SG1813
ATOM 1813 ND2 ASN 232 86, .466 16 .272 37, .491 1 .00 47 .01 1SG1814
ATOM 1814 C ASN 232 90, .210 17 .028 35, .075 1. .00 47. .01 1SG1815
ATOM 1815 O ASN 232 90 .058 17 .943 34, .273 1 .00 47 .01 1SG1816
ATOM 1816 N LEU 233 90 .619 15 .809 34, .686 1. .00 46. .88 1SG1817
ATOM 1817 CA LEU 233 90, .966 15 .565 33, .317 1 .00 46 .88 1SG1818
ATOM 1818 CB LEU 233 92 .353 14 .878 33, .229 1. .00 46, .88 1SG1819
ATOM 1819 CG LEU 233 92 .432 13 .429 32, .701 1 .00 46 .88 1SG1820
ATOM 1820 CD2 LEU 233 91 .961 13 .268 31, .248 1. .00 46, .88 1SG1821
ATOM 1821 CDl LEU 233 91 .744 12 .468 33, .684 1 .00 46 .88 1SG1822
ATOM 1822 C LEU 233 89 .873 14 .802 32. .629 1. .00 46, .88 1SG1823
ATOM 1823 O LEU 233 89 .406 13 .776 33. .118 1. .00 46 .88 1SG1824
ATOM 1824 N THR 234 89 .401 15 .323 31. .474 1, .00 46, .00 1SG1825
ATOM 1825 CA THR 234 88 .414 14 .608 30, .715 1 .00 46 .00 1SG1826
ATOM 1826 CB THR 234 87 .000 15 .096 30, .900 1. .00 46 .00 1SG1827
ATOM 1827 OGl THR 234 86 .858 16 .417 30, .399 1 .00 46 .00 1SG1828
ATOM 1828 CG2 THR 234 86 .651 15 .058 32, .399 1, .00 46 .00 1SG1829
ATOM 1829 C THR 234 88 .766 14 .772 29, .265 1 .00 46 .00 1SG1830
ATOM 1830 O THR 234 89, .117 15 .865 28, .823 1, .00 46 .00 1SG1831
ATOM 1831 N ASP 235 88 .689 13 .675 28, .484 1, .00 48 .68 1SG1832
ATOM 1832 CA ASP 235 89, .041 13, .726 27, .089 1, .00 48, .68 1SG1833
ATOM 1833 CB ASP 235 89 .329 12 .345 26, .478 1 .00 48 .68 1SG1834
ATOM 1834 CG ASP 235 88, .050 11 .524 26, .587 1 .00 48 .68 1SG1835
ATOM 1835 ODl ASP 235 87 .484 11 .468 27, .711 1 .00 48 .68 1SG1836
ATOM 1836 OD2 ASP 235 87, .627 10 .937 25. .556 1, .00 48. .68 1SG1837
ATOM 1837 C ASP 235 87 .909 14 .318 26. .310 1, .00 48 .68 1SG1838
ATOM 1838 O ASP 235 86. .748 14 .271 26 .716 1 .00 48 .68 1SG1839
ATOM 1839 N PRO 236 88 .262 14 .894 25. .189 1, .00 51 .23 1SG1840
ATOM 1840 CA PRO 236 87 .268 15 .467 24. .321 1 .00 51 .23 1SG1841
ATOM 1841 CD PRO 236 89 .518 15 .627 25. .126 1, .00 51 .23 1SG1842
ATOM 1842 CB PRO 236 88 .016 16 .417 23, .391 1 .00 51 .23 1SG1843
ATOM 1843 CG PRO 236 89 .248 16, .833 24 , .213 1, .00 51 .23 1SG1844
ATOM 1844 C PRO 236 86 .490 14 .409 23, .598 1 .00 51 .23 1SG1845
ATOM 1845 O PRO 236 87 .050 13, .373 23. .250 1, .00 51. .23 1SG1846
ATOM 1846 N PRO 237 85 .235 14 .669 23 , .365 1. .00 52 .20 1SG1847
ATOM 1847 CA PRO 237 84 .344 13, .753 22. .699 1, .00 52. .20 1SG1848
ATOM 1848 CD PRO 237 84 .518 15 .647 24. .164 1, .00 52 .20 1SG1849
ATOM 1849 CB PRO 237 82, .926 14, .220 23. .043 1. .00 52, .20 1SG1850
ATOM 1850 CG PRO 237 83 .102 15 .655 23 , .571 1. .00 52. .20 1SG1851
ATOM 1851 C PRO 237 84, .596 13, .659 21. .228 1. .00 52 .20 1SG1852
ATOM 1852 O PRO 237 83 .907 12, .893 20. .559 1. .00 52, .20 1SG1853
ATOM 1853 N PHE 238 85. .540 14, .440 20. .686 1. .00 51, .72 1SG1854
ATOM 1854 CA PHE 238 85. .727 14, .448 19. .266 1. .00 51, .72 1SG1855
ATOM 1855 CB PHE 238 85. .127 15, .723 18. .650 1. .00 51, .72 1SG1856
ATOM 1856 CG PHE 238 85. .531 16, .856 19. .535 1. .00 51, .72 1SG1857
ATOM 1857 CDl PHE 238 84. .782 17. .162 20. ,645 1. .00 51. .72 1SG1858
ATOM 1858 CD2 PHE 238 86. .639 17. .618 19. .284 1. .00 51. .72 1SG1859
ATOM 1859 CE1 PHE 238 85. .116 18 .195 21, .490 1. .00 51. .72 1SG1860
ATOM 1860 CE2 PHE 238 86, .976 18, .653 20. .126 1. .00 51. .72 1SG1861
ATOM 1861 CZ PHE 238 86. .225 18. .953 21. .231 1. .00 51. .72 1SG1862
ATOM 1862 C PHE 238 87, .180 14. .334 18. .920 1. ,00 51. .72 1SG1863
ATOM 1863 O PHE 238 88, .041 14. .305 19. .797 1. .00 51, .72 1SG1864
ATOM 1864 N SER 239 87, .473 14. .217 17. ,605 1. ,00 46, .29 1SG1865
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ATOM 1980 N TYR 254 102..505 29..830 9..395 1..00 46..19 1SG1981
ATOM 1981 CA TYR 254 101. .081 29. .660 9. .292 1. .00 46. .19 1SG1982
ATOM 1982 CB TYR 254 100. .603 29. .004 7, .984 1. ,00 46. .19 1SG1983
ATOM 1983 CG TYR 254 101. .094 29. .791 6. .820 1. .00 46. .19 1SG1984
ATOM 1984 CDl TYR 254 100. .666 31. .076 6. .585 1. ,00 46. .19 1SG1985
ATOM 1985 CD2 TYR 254 101. .969 29. .212 5, .933 1. .00 46. .19 1SG1986
ATOM 1986 CE1 TYR 254 101. .130 31, .775 5. .495 1. .00 46. .19 1SG1987
ATOM 1987 CE2 TYR 254 102, .434 29, .907 4, .843 1. .00 46, .19 1SG1988
ATOM 1988 CZ TYR 254 102, .017 31, .196 4, .622 1. .00 46, .19 1SG1989
ATOM 1989 OH TYR 254 102. .491 31, .918 3. .505 1. .00 46. .19 1SG1990
ATOM 1990 C TYR 254 100. .651 28, .712 10. .373 1. .00 46. .19 1SG1991
ATOM 1991 0 TYR 254 101. .316 27, .710 10. .635 1. .00 46, .19 1SG1992
ATOM 1992 N ILE 255 99. .507 28 .997 11. .029 1. .00 42, .29 1SG1993
ATOM 1993 CA ILE 255 99. .037 28 .102 12, .046 1, .00 42, .29 1SG1994
ATOM 1994 CB ILE 255 99 .003 28 .696 13, .425 1. .00 42, .29 1SG1995
ATOM 1995 CG2 ILE 255 100. .441 29 .083 13 .811 1, .00 42 .29 1SG1996
ATOM 1996 CGI ILE 255 98 .010 29 .862 13 .487 1. .00 42 .29 1SG1997
ATOM 1997 CDl ILE 255 97 .740 30 .367 14 .904 1, .00 42 .29 1SG1998
ATOM 1998 C ILE 255 97 .647 27 .688 11 .691 1. .00 42 .29 1SG1999
ATOM 1999 0 ILE 255 96 .852 28 .486 11 .194 1. .00 42 .29 1SG2000
ATOM 2000 N GLY 256 97 .330 26 .399 11 .921 1. .00 37 .87 1SG2001
ATOM 2001 CA GLY 256 96 .014 25 .913 11 .644 1. .00 3 .87 1SG2002
ATOM 2002 C GLY 256 95 .408 25 .613 12 .972 1. .00 37 .87 1SG2003
ATOM 2003 0 GLY 256 95, .798 24, .664 13, .651 1. .00 37, .87 1SG2004
ATOM 2004 N ILE 257 94, .412 26 .426 13. .362 1. .00 37, .26 1SG2005
ATOM 2005 CA ILE 257 93, .768 26 .259 14, .628 1. .00 37, .26 1SG2006
ATOM 2006 CB ILE 257 93, .548 27 .579 15 .316 1. .00 37, .26 1SG2007
ATOM 2007 CG2 ILE 257 94, .921 28 .145 15, .709 1. .00 37, .26 1SG2008
ATOM 2008 CGI ILE 257 92, .724 28 .524 14 .426 1, .00 37, .26 1SG2009
ATOM 2009 CDl ILE 257 92 .447 29 .885 15 .061 1, .00 37, .26 1SG2010
ATOM 2010 C ILE 257 92 .468 25 .561 14 .387 1, .00 37 .26 1SG2011
ATOM 2011 O ILE 257 91, .501 26 .131 13 .887 1, .00 37 .26 1SG2012
ATOM 2012 N ALA 258 92 .433 24 .272 14 .764 1. .00 36 .51 1SG2013
ATOM 2013 CA ALA 258 91 .316 23 .401 14 .539 1. .00 36 .51 1SG2014
ATOM 2014 CB ALA 258 91 .636 21 .936 14 .868 1. .00 36 .51 1SG2015
ATOM 2015 C ALA 258 90 .163 23 .773 15 .414 1. .00 36 .51 1SG2016
ATOM 2016 O ALA 258 90 .316 24 .437 16 .436 1. .00 36 .51 1SG2017
ATOM 2017 N GLU 259 88 .960 23 .326 14 .999 1. .00 38 .44 1SG2018
ATOM 2018 CA GLU 259 87 .736 23 .539 15 .714 1. .00 38 .44 1SG2019
ATOM 2019 CB GLU 259 86 .515 22 .942 14 .988 1. .00 38 .44 1SG2020
ATOM 2020 CG GLU 259 86 .598 21 .422 14 .823 1, .00 38 .44 1SG2021
ATOM 2021 CD GLU 259 85 .346 20 .942 14 .100 1, .00 38 .44 1SG2022
ATOM 2022 OEl GLU 259 84 .711 21 .769 13 .392 1, .00 38 .44 1SG2023
ATOM 2023 OE2 GLU 259 85 .011 19 .737 14 .245 1, .00 38 .44 1SG2024
ATOM 2024 C GLU 259 87 .866 22 .827 17 .020 1, .00 38 .44 1SG2025
ATOM 2025 0 GLU 259 87, .368 23 , .283 18, .048 1, .00 38, .44 1SG2026
ATOM 2026 N TYR 260 88. .569 21. .682 17. .001 1. .00 42, .00 1SG2027
ATOM 2027 CA TYR 260 88. .780 20. .858 18, .153 1. .00 42, .00 1SG2028
ATOM 2028 CB TYR 260 89. .691 19. .670 17, .772 1. .00 42, .00 1SG2029
ATOM 2029 CG TYR 260 90. .122 18. .886 18, .963 1. .00 42, .00 1SG2030
ATOM 2030 CDl TYR 260 91, .116 19. .373 19, .775 1. .00 42, .00 1SG2031
ATOM 2031 CD2 TYR 260 89, .584 17. .650 19, .245 1. .00 42, .00 1SG2032
ATOM 2032 CE1 TYR 260 91, .530 18, .663 20, .867 1. .00 42, .00 1SG2033
ATOM 2033 CE2 TYR 260 89, .996 16, .933 20, .344 1, .00 42, .00 1SG2034
ATOM 2034 CZ TYR 260 90, .972 17. .447 21, .164 1. .00 42, .00 1SG2035
ATOM 2035 OH TYR 260 91, .417 16. .735 22, .298 1, .00 42, .00 1SG2036
ATOM 2036 C TYR 260 89, .451 21. .715 19, .185 1. .00 42. .00 1SG2037 ATOM 2037 O TYR 260 89,.064 21..713 20..353 1..00 42.00 1SG2038
ATOM 2038 N PHE 261 90, .455 22. .504 18. .763 1. .00 43. .04 1SG2039
ATOM 2039 CA PHE 261 91, .204 23. .341 19. .656 1. .00 43. .04 1SG2040
ATOM 2040 CB PHE 261 92 .230 24 .189 18, .875 1. .00 43 .04 1SG2041
ATOM 2041 CG PHE 261 92, .835 25, .257 19. .725 1, .00 43. .04 1SG2042
ATOM 2042 CDl PHE 261 93. .801 24, .977 20. .665 1. .00 43. .04 1SG2043
ATOM 2043 CD2 PHE 261 92 .450 26 .567 19 .545 1 .00 43 .04 1SG2044
ATOM 2044 CE1 PHE 261 94 .349 25 .989 21. .422 1. .00 43 .04 1SG2045
ATOM 2045 CE2 PHE 261 92. .994 27, .579 20, .298 1. .00 43. .04 1SG2046
ATOM 2046 CZ PHE 261 93 .948 27 .291 21 .243 1 .00 43 .04 1SG2047
ATOM 2047 C PHE 261 90 .262 24 .264 20, .367 1. .00 43 .04 1SG2048
ATOM 2048 O PHE 261 90. .287 24, .360 21, .594 1. .00 43 .04 1SG2049
ATOM 2049 N PHE 262 89. .386 24, .950 19, .611 1. .00 44. .03 1SG2050
ATOM 2050 CA PHE 262 88 .468 25 .904 20 .171 1, .00 44 .03 1SG2051
ATOM 2051 CB PHE 262 87 .610 26 .609 19, .109 1, .00 44 .03 1SG2052
ATOM 2052 CG PHE 262 88. .497 27, .386 18, .206 1, .00 44, .03 1SG2053
ATOM 2053 CDl PHE 262 89 .073 28 .556 18 .640 1 .00 44 .03 1SG2054
ATOM 2054 CD2 PHE 262 88 .730 26 .953 16. .921 1, .00 44 .03 1SG2055
ATOM 2055 CE1 PHE 262 89 .888 29, .279 17, .805 1, .00 44 .03 1SG2056
ATOM 2056 CE2 PHE 262 89 .544 27 .672 16 .081 1 .00 44 .03 1SG2057
ATOM 2057 CZ PHE 262 90 .122 28 .834 16. .527 1 .00 44 .03 1SG2058
ATOM 2058 C PHE 262 87, .483 25 .220 21, .070 1, .00 44 .03 1SG2059
ATOM 2059 O PHE 262 87 .142 25 .730 22 .136 1 .00 44 .03 1SG2060
ATOM 2060 N LYS 263 86 .979 24 .052 20 .635 1, .00 43 .18 1SG2061
ATOM 2061 CA LYS 263 85 .952 23, .321 21, .324 1, .00 43 .18 1SG2062
ATOM 2062 CB LYS 263 85. .609 22, .004 20, .600 1, .00 43 .18 1SG2063
ATOM 2063 CG LYS 263 85 .024 22 .160 19, .193 1 .00 43 .18 1SG2064
ATOM 2064 CD LYS 263 83 .628 22 .781 19, .168 1, .00 43 .18 1SG2065
ATOM 2065 CE LYS 263 82, .545 21, .829 19, .682 1, .00 43 .18 1SG2066
ATOM 2066 NZ LYS 263 82 .787 21 .514 21 .109 1 .00 43 .18 1SG2067
ATOM 2067 C LYS 263 86 .437 22, .918 22, .683 1, .00 43 .18 1SG2068
ATOM 2068 O LYS 263 85, .684 22, .953 23, .654 1, .00 43 .18 1SG2069
ATOM 2069 N SER 264 87 .714 22 .516 22 .782 1 .00 39 .39 1SG2070
ATOM 2070 CA SER 264 88 .252 22 .018 24, .015 1, .00 39 .39 1SG2071
ATOM 2071 CB SER 264 89, .748 21, .692 23, .900 1, .00 39 .39 1SG2072
ATOM 2072 OG SER 264 89 .973 20 .827 22 .800 1 .00 39 .39 1SG2073
ATOM 2073 C SER 264 88 .148 23 .089 25, .051 1, .00 39 .39 1SG2074
ATOM 2074 O SER 264 87, .950 22. .810 26, .233 1, .00 39 .39 1SG2075
ATOM 2075 N ALA 265 88 .300 24, .352 24, .629 1 .00 34 .86 1ΞG2076
ATOM 2076 CA ALA 265 88 .263 25 .430 25 .567 1. .00 34 .86 1SG2077
ATOM 2077 CB ALA 265 88, .512 26, .797 24. .904 1, .00 34, .86 1SG2078
ATOM 2078 C ALA 265 86, .920 25, .484 26. .219 1, .00 34, .86 1SG2079
ATOM 2079 O ALA 265 86 .822 25 .616 27. .438 1, .00 34, .86 1SG2080
ATOM 2080 N SER 266 85, .839 25, .361 25, .428 1, .00 33, .23 1SG2081
ATOM 2081 CA SER 266 84, .524 25, .489 25. .979 1. .00 33, .23 1SG2082
ATOM 2082 CB SER 266 83 .430 25. .526 24. .896 1, .00 33 .23 1SG2083
ATOM 2083 OG SER 266 83, .640 26, .644 24, .042 1. .00 33, .23 1SG2084
ATOM 2084 C SER 266 84, .248 24, .361 26, .923 1. .00 33, .23 1SG2085
ATOM 2085 O SER 266 83 .563 24, .543 27, .929 1. .00 33, .23 1SG2086
ATOM 2086 N PHE 267 84, .771 23, .159 26, .619 1. .00 34, .06 1SG2087
ATOM 2087 CA PHE 267 84. .511 22 , .008 27. .437 1. .00 34. .06 1SG2088
ATOM 2088 CB PHE 267 85, .133 20, .723 26. .842 1. .00 34. .06 1SG2089
ATOM 2089 CG PHE 267 84, .458 19, .508 27. .399 1. .00 34 , .06 1SG2090
ATOM 2090 CDl PHE 267 83. .257 19. .086 26. .872 1. .00 34. .06 1SG2091
ATOM 2091 CD2 PHE 267 85. .012 18. .772 28. ,421 1. .00 34. .06 1SG2092
ATOM 2092 CE1 PHE 267 82. .611 17. .970 27. .354 1. .00 34. .06 1SG2093
ATOM 2093 CE2 PHE 267 84. .374 17. .652 28. .907 1. .00 34. .06 1SG2094 ATOM 2094 CZ PHE 267 83..171 17,.248 28..378 1..00 34..06 1SG2095
ATOM 2095 C PHE 267 85. .149 22, .235 28. .771 1. .00 34. .06 1SG2096
ATOM 2096 O PHE 267 84. .526 22, .041 29. .813 1. .00 34. .06 1SG2097
ATOM 2097 N ALA 268 86. .422 22, .676 28. .754 1. .00 37. .55 1SG2098
ATOM 2098 CA ALA 268 87, .207 22 .830 29. .946 1. .00 37. .55 1SG2099
ATOM 2099 CB ALA 268 88. .655 23 .265 29. .642 1. .00 37. .55 1SG2100
ATOM 2100 C ALA 268 86. .624 23 .851 30. .874 1. .00 37. .55 1SG2101
ATOM 2101 O ALA 268 86. .561 23, .621 32. .081 1. .00 37. .55 1SG2102
ATOM 2102 N HIS 269 86. .198 25, .023 30. .365 1. .00 42. .32 1SG2103
ATOM 2103 CA HIS 269 85, .688 26 .003 31. .282 1. .00 42, .32 1SG2104
ATOM 2104 NDl HIS 269 84, .195 29 .377 30. .564 1. .00 42. .32 1SG2105
ATOM 2105 CG HIS 269 84. .670 28, .158 30. .128 1. .00 42. .32 1SG2106
ATOM 2106 CB HIS 269 85. .816 27, .475 30. .811 1. .00 42. .32 1SG2107
ATOM 2107 NE2 HIS 269 83. .063 28 .880 28. .718 1, .00 42. .32 1SG2108
ATOM 2108 CD2 HIS 269 83. .963 27 .865 29. .004 1 , .00 42, .32 1SG2109
ATOM 2109 CE1 HIS 269 83. .240 29, .763 29. .684 1. .00 42 , .32 1SG2110
ATOM 2110 C HIS 269 84. .315 25, .631 31. .779 1. .00 42. .32 1SG2111
ATOM 2111 O HIS 269 83. .924 26, .003 32. .882 1. .00 42. .32 1SG2112
ATOM 2112 N PHE 270 83. .532 24 .893 30. .965 1. .00 42, .60 1SG2113
ATOM 2113 CA PHE 270 82. .192 24 .479 31. .315 1. .00 42, .60 1SG2114
ATOM 2114 CB PHE 270 81. .539 23, .693 30. .156 1. .00 42, .60 1SG2115
ATOM 2115 CG PHE 270 80. .146 23. .281 30. .504 1. .00 42, .60 1SG2116
ATOM 2116 CDl PHE 270 79. .908 22 .114 31. .195 1. .00 42 .60 1SG2117
ATOM 2117 CD2 PHE 270 79. .076 24 .059 30, .130 1, .00 42, .60 1SG2118
ATOM 2118 CE1 PHE 270 78, .627 21 .726 31, .523 1. .00 42, .60 1SG2119
ATOM 2119 CE2 PHE 270 77, .797 23 .668 30. .452 1. .00 42, .60 1SG2120
ATOM 2120 CZ PHE 270 77, .563 22, .506 31. .146 1. .00 42, .60 1SG2121
ATOM 2121 C PHE 270 82, .229 23 .559 32, .507 1. .00 42 .60 1SG2122
ATOM 2122 O PHE 270 81, .535 23 .775 33 , .499 1. .00 42, .60 1SG2123
ATOM 2123 N THR 271 83, .081 22, .519 32 , .446 1, .00 41, .80 1SG2124
ATOM 2124 CA THR 271 83, .182 21, .494 33, .450 1. .00 41. .80 1SG2125
ATOM 2125 CB THR 271 84, .144 20 .418 33, .056 1. .00 41 .80 1SG2126
ATOM 2126 OGl THR 271 85, .439 20 .969 32, .869 1, .00 41, .80 1SG2127
ATOM 2127 CG2 THR 271 83, .637 19, .775 31. .755 1, .00 41, .80 1SG2128
ATOM 2128 C THR 271 83, .655 22, .073 34. .748 1, .00 41, .80 1SG2129
ATOM 2129 O THR 271 83. .320 21, .573 35. .822 1. .00 41, .80 1SG2130
ATOM 2130 N ALA 272 84, .475 23 .131 34. .674 1. .00 39 .92 1SG2131
ATOM 2131 CA ALA 272 85, .022 23, .778 35. .830 1. .00 39, .92 1SG2132
ATOM 2132 CB ALA 272 85. .949 24, .956 35. .476 1. .00 39, .92 1SG2133
ATOM 2133 C ALA 272 83. .887 24, .304 36. .653 1. .00 39. .92 1SG2134
ATOM 2134 O ALA 272 83. .986 24 .364 37. .877 1. .00 39 .92 1SG2135
ATOM 2135 N GLY 273 82. .780 24, .719 36, .008 1. .00 38. .38 1SG2136
ATOM 2136 CA GLY 273 81. .664 25, .226 36. .756 1. .00 38, .38 1SG2137
ATOM 2137 C GLY 273 81, .788 26, .711 36. .803 1. .00 38, .38 1SG2138
ATOM 2138 O GLY 273 81. .089 27. .385 37. .557 1. .00 38. .38 1SG2139
ATOM 2139 N VAL 274 82, .734 27, .243 36. .011 1. .00 39. .47 1SG2140
ATOM 2140 CA VAL 274 82, .986 28, .649 35. .926 1, .00 39, .47 1SG2141
ATOM 2141 CB VAL 274 84. .270 28, .977 35. .227 1. .00 39. .47 1SG2142
ATOM 2142 CGI VAL 274 84. .142 28, .592 33. .746 1. .00 39. .47 1SG2143
ATOM 2143 CG2 VAL 274 84. .567 30, .468 35. .452 1, .00 39. .47 1SG2144
ATOM 2144 C VAL 274 81. .897 29. .371 35. .196 1, .00 39, .47 1SG2145
ATOM 2145 O VAL 274 81, .589 30. .508 35. .543 1. .00 39. .47 1SG2146
ATOM 2146 N PHE 275 81. .302 28. .752 34. .149 1. .00 40. .56 1SG2147
ATOM 2147 CA PHE 275 80. .359 29. .470 33. ,333 1. .00 40. .56 1SG2148
ATOM 2148 CB PHE 275 80. .083 28. .771 31. .989 1. .00 40, .56 1SG2149
ATOM 2149 CG PHE 275 19 . .492 29. .768 31. , 050 1. .00 40. .56 1SG2150
ATOM 2150 CDl PHE 275 80. .325 30. .567 30. ,301 1. .00 40. .56 1SG2151 ATOM 2151 CD2 PHE 275 78..131 29..913 30..906 1..00 40..56 1SG2152
ATOM 2152 CE1 PHE 275 79, .819 31. .496 29. .424 1. .00 40. .56 1SG2153
ATOM 2153 CE2 PHE 275 77, .617 30 .842 30 .029 1. .00 40. .56 1SG2154
ATOM 2154 CZ PHE 275 78 .460 31 .635 29 .286 1. .00 40. .56 1SG2155
ATOM 2155 C PHE 275 79. .056 29, .561 34. .063 1, .00 40. .56 1SG2156
ATOM 2156 O PHE 275 78. .079 28 .892 33 .721 1. .00 40. .56 1SG2157
ATOM 2157 N ASN 276 79 .015 30 .443 35 .077 1, .00 42. .27 1SG2158
ATOM 2158 CA ASN 276 77 .836 30 .658 35 .856 1. .00 42. .27 1SG2159
ATOM 2159 CB ASN 276 77, .796 29, .810 37 .138 1 .00 42. .27 1SG2160
ATOM 2160 CG ASN 276 76, .504 30 .120 37 .880 1. .00 42. .27 1SG2161
ATOM 2161 ODl ASN 276 76 .527 30 .556 39 .029 1. .00 42. .27 1SG2162
ATOM 2162 ND2 ASN 276 75 .345 29 .889 37 .207 1. .00 42. .27 1SG2163
ATOM 2163 C ASN 276 77, .874 32 .091 36 .271 1 .00 42. .27 1SG2164
ATOM 2164 O ASN 276 78, .948 32 .662 36 .454 1. .00 42. .27 1SG2165
ATOM 2165 N VAL 277 76 .698 32 .729 36 .409 1. .00 43. .56 1SG2166
ATOM 2166 CA VAL 277 76 .715 34 .096 36 .827 1. .00 43. .56 1SG2167
ATOM 2167 CB VAL 277 76 .774 35 .070 35 .686 1 .00 43. .56 1SG2168
ATOM 2168 CGI VAL 277 76, .542 36 .492 36 .224 1, .00 43. .56 1SG2169
ATOM 2169 CG2 VAL 277 78 .140 34 .908 34 .997 1. .00 43, .56 1SG2170
ATOM 2170 C VAL 277 75 .458 34 .363 37 .579 1, .00 43, .56 1SG2171
ATOM 2171 O VAL 277 74 .415 33 .774 37 .299 1 .00 43 .56 1SG2172
ATOM 2172 N THR 278 75, .546 35 .271 38. .568 1, .00 45, .25 1SG2173
ATOM 2173 CA THR 278 74 .407 35 .650 39 .343 1, .00 45, .25 1SG2174
ATOM 2174 CB THR 278 74 .638 35 .643 40 .822 1, .00 45, .25 1SG2175
ATOM 2175 OGl THR 278 75 .745 36 .471 41 .145 1, .00 45 .25 1SG2176
ATOM 2176 CG2 THR 278 74, .875 34 .205 41, .287 1, .00 45 .25 1SG2177
ATOM 2177 C THR 278 74 .108 37 .059 38 .987 1, .00 45, .25 1SG2178
ATOM 2178 O THR 278 74 .993 37 .911 38 .950 1, .00 45, .25 1SG2179
ATOM 2179 N LEU 279 72 .829 37 .331 38 .701 1, .00 45, .80 1SG2180
ATOM 2180 CA LEU 279 72, .445 38 .657 38 .349 1, .00 45 .80 1SG2181
ATOM 2181 CB LEU 279 71 .599 38, .665 37, .072 1, .00 45, .80 1SG2182
ATOM 2182 CG LEU 279 72 .378 38 .040 35 .896 1. .00 45. .80 1SG2183
ATOM 2183 CD2 LEU 279 7 .651 38 .838 35 .579 1, .00 45. .80 1SG2184
ATOM 2184 CDl LEU 279 71, .501 37, .856 34 .659 1, .00 45, .80 1SG2185
ATOM 2185 C LEU 279 71, .632 39. .163 39, .489 1. .00 45. .80 1SG2186
ATOM 2186 O LEU 279 70, .727 38, .481 39, .972 1. .00 45, .80 1SG2187
ATOM 2187 N SER 280 71 .961 40 .383 39 .958 1. .00 44, .14 1SG2188
ATOM 2188 CA SER 280 71, .278 40 .974 41 .068 1. .00 44, .14 1SG2189
ATOM 2189 CB SER 280 72, .216 41, .409 42 , .206 1. .00 44. .14 1SG2190
ATOM 2190 OG SER 280 71, .466 41, .987 43. .263 1. .00 44. .14 1SG2191
ATOM 2191 C SER 280 70, .602 42, .207 40. .558 1. .00 44. .14 1SG2192
ATOM 2192 O SER 280 70 .951 42, .736 3 .504 1. .00 44, .14 1SG2193
ATOM 2193 N THR 281 69, .598 42. .686 41. .313 1. ,00 43. .37 1SG2194
ATOM 2194 CA THR 281 68, .811 43. .824 40. .936 1. ,00 43. .37 1SG2195
ATOM 2195 CB THR 281 67, .734 44, .140 41. .931 1. .00 43. .37 1SG2196
ATOM 2196 OGl THR 281 66, .867 45, .140 41. .415 1. .00 43. .37 1SG2197
ATOM 2197 CG2 THR 281 68. .394 44. .630 43. .232 1. .00 43. .37 1SG2198
ATOM 2198 C THR 281 69, .699 45. .026 40. .848 1. .00 43. .37 1SG2199
ATOM 2199 O THR 281 69, .477 45. .914 40. .028 1. .00 43. .37 1SG2200
ATOM 2200 N GLU 282 70. .733 45, .079 41. .703 1. .00 42. .03 1SG2201
ATOM 2201 CA GLU 282 71. .620 46. .204 41. .802 1. .00 42. .03 1SG2202
ATOM 2202 CB GLU 282 72. .689 46. .001 42. .891 1. .00 42. .03 1SG2203
ATOM 2203 CG GLU 282 73. .653 47. .177 43. .046 1. .00 42. .03 1SG2204
ATOM 2204 CD GLU 282 74. .795 47. .007 42. .052 1. .00 42. .03 1SG2205
ATOM 2205 OEl GLU 282 74. .865 45, .927 41. .408 1. ,00 42. ,03 1SG2206
ATOM 2206 OE2 GLU 282 75. .618 47. .954 41. .930 1. 00 42. 03 1SG2207
ATOM 2207 C GLU 282 72. .327 46. .442 40. .500 1. ,00 42. ,03 1SG2208 ATOM 2208 O GLU 282 72,.637 47..582 40..160 1..00 42..03 1SG2209
ATOM 2209 N GLU 283 72, .607 45, .372 39. .735 1. .00 42. .31 1SG2210
ATOM 2210 CA GLU 283 73. .379 45, .471 38. .528 1. ,00 42. .31 1SG2211
ATOM 2211 CB GLU 283 73. .575 44 .116 37, .828 1. .00 42. .31 1SG2212
ATOM 2212 CG GLU 283 74. .446 43, .123 38, .599 1. .00 42. .31 1SG2213
ATOM 2213 CD GLU 283 74 .527 41 .853 37, .764 1. .00 42, .31 1SG2214
ATOM 2214 OEl GLU 283 73. .898 41, .824 36, .672 1. .00 42 , .31 1SG2215
ATOM 2215 OE2 GLU 283 75, .217 40, .895 38. .205 1. .00 42. .31 1SG2216
ATOM 2216 C GLU 283 72, .735 46 .372 37. .509 1. .00 42. .31 1SG2217
ATOM 2217 O GLU 283 73, .443 47, .073 36. .786 1. .00 42. .31 1SG2218
ATOM 2218 N ILE 284 71, .392 46 .380 37. .392 1. .00 45. .49 1SG2219
ATOM 2219 CA ILE 284 70. .794 47, .145 36, .326 1. .00 45. .49 1SG2220
ATOM 2220 CB ILE 284 69. .768 46 .366 35 .558 1. .00 45, .49 1SG2221
ATOM 2221 CG2 ILE 284 70, .477 45, .181 34, .883 1. .00 45. .49 1SG2222
ATOM 2222 CGI ILE 284 68 .611 45 .955 36 .483 1. .00 45. .49 1SG2223
ATOM 2223 CDl ILE 284 67. .405 45 .387 35, .736 1. .00 45. .49 1SG2224
ATOM 2224 C ILE 284 70. .123 48, .389 36, .833 1. .00 45. .49 1SG2225
ATOM 2225 O ILE 284 69 .367 48 .370 37, .803 1. .00 45. .49 1SG2226
ATOM 2226 N SER 285 70, .453 49 .528 36, .187 1. .00 48. .23 1SG2227
ATOM 2227 CA SER 285 69 .925 50 .831 36, .502 1. .00 48. .23 1SG2228
ATOM 2228 CB SER 285 70, .846 51 .964 36, .018 1. .00 48. .23 1SG2229
ATOM 2229 OG SER 285 72, .101 51 .889 36 .679 1, .00 48 .23 1SG2230
ATOM 2230 C SER 285 68, .563 51, .098 35, .897 1. .00 48. .23 1SG2231
ATOM 2231 O SER 285 67 .773 51 .848 36 .467 1. .00 48 .23 1SG2232
ATOM 2232 N ASN 286 68, .254 50 .499 34, .727 1. .00 51. .13 1SG2233
ATOM 2233 CA ASN 286 67, .102 50, .829 33, .917 1. .00 51. .13 1SG2234
ATOM 2234 CB ASN 286 67, .231 50 .249 32 .490 1. .00 51, .13 1SG2235
ATOM 2235 CG ASN 286 66, .377 51, .045 31, .508 1. .00 51, .13 1SG2236
ATOM 2236 ODl ASN 286 65, .256 50 .666 31 .173 1. .00 51 .13 1SG2237
ATOM 2237 ND2 ASN 286 66, .927 52 .195 31, .032 1. .00 51, .13 1SG2238
ATOM 2238 C ASN 286 65 .798 50 .367 34 .512 1. .00 51 .13 1SG2239
ATOM 2239 O ASN 286 65, .736 49 .867 35, .633 1. .00 51, .13 1SG2240
ATOM 2240 N HIS 287 64, .710 50 .586 33. .733 1. .00 53. .33 1SG2241
ATOM 2241 CA HIS 287 63, .327 50, .358 34 .059 1. .00 53, .33 1SG2242
ATOM 2242 NDl HIS 287 63. .330 52, .696 31, .636 1. .00 53. .33 1SG2243
ATOM 2243 CG HIS 287 62, .420 52, .157 32 .517 1. .00 53, .33 1SG2244
ATOM 2244 CB HIS 287 62, .380 50, .708 32, .899 1. .00 53, .33 1SG2245
ATOM 2245 NE2 HIS 287 62, .027 54 .368 32 .305 1, .00 53, .33 1SG2246
ATOM 2246 CD2 HIS 287 61, .631 53. .192 32, .916 1. .00 53, .33 1SG2247
ATOM 2247 CE1 HIS 287 63, .050 5 .020 31 .545 1. .00 53, .33 1SG2248
ATOM 2248 C HIS 287 63 , .076 48, .930 34, .396 1. .00 53, .33 1SG2249
ATOM 2249 0 HIS 287 62. .414 48, .646 35, .394 1. .00 53. .33 1SG2250
ATOM 2250 N PHE 288 63, .576 47, .981 33, .584 1. .00 55. .23 1SG2251
ATOM 2251 CA PHE 288 63. .318 46. .624 33, .958 1. .00 55. .23 1SG2252
ATOM 2252 CB PHE 288 63, .865 45. .575 32 .972 1. .00 55, .23 1SG2253
ATOM 2253 CG PHE 288 63. .007 45. .587 31, .754 1. .00 55. .23 1SG2254
ATOM 2254 CDl PHE 288 63. .276 46. .446 30 .713 1. .00 55. .23 1SG2255
ATOM 2255 CD2 PHE 288 61. .927 44. .741 31, .657 1. .00 55. .23 1SG2256
ATOM 2256 CE1 PHE 288 62. .482 46. .456 29. .591 1. .00 55, .23 1SG2257
ATOM 2257 CE2 PHE 288 61. .129 44, .746 30, .537 1. .00 55. .23 1SG2258
ATOM 2258 CZ PHE 288 61. .407 45. .605 29, .501 1. .00 55. .23 1SG2259
ATOM 2259 C PHE 288 64. .006 46. .420 35, .261 1. .00 55. .23 1SG2260
ATOM 2260 O PHE 288 65. .116 46. .904 35, .475 1. .00 55. .23 1SG2261
ATOM 2261 N VAL 289 63. .335 45. .730 36, .196 1. .00 56. .72 1SG2262
ATOM 2262 CA VAL 289 63. .950 45. .505 37. .465 1. .00 56. .72 1SG2263
ATOM 2263 CB VAL 289 63. .465 46. .440 38. .535 1. .00 56. .72 1SG2264
ATOM 2264 CGI VAL 289 61. .930 46. .433 38. .549 1. .00 56. ,72 1SG2265 ATOM 2265 CG2 VAL 289 64,.111 46,.029 39,.869 1.,00 56..72 1SG2266
ATOM 2266 C VAL 289 63, .685 44, .096 37, .859 1. ,00 56. .72 1SG2267
ATOM 2267 O VAL 289 62, .630 43, .541 37. .554 1. .00 56. .72 1SG2268
ATOM 2268 N GLN 290 64 .668 43 .469 38, .536 1. .00 61. .60 1SG2269
ATOM 2269 CA GLN 290 64, .462 42, .115 38, .935 1. .00 61. .60 1SG2270
ATOM 2270 CB GLN 290 65, .759 41, .283 38. .938 1. .00 61. .60 1SG2271
ATOM 2271 CG GLN 290 66 .849 41 .747 39. .902 1. .00 61. .60 1SG2272
ATOM 2272 CD GLN 290 68 .125 41 .041 39. .461 1. .00 61. .60 1SG2273
ATOM 2273 OEl GLN 290 68 .634 41 .300 38, .372 1. .00 61. .60 1SG2274
ATOM 2274 NE2 GLN 290 68, .655 40, .120 40, .308 1. .00 61. .60 1SG2275
ATOM 2275 C GLN 290 63 .842 42 .140 40, .289 1. .00 61. .60 1SG2276
ATOM 2276 O GLN 290 64 .507 42 .021 41, .315 1. .00 61. .60 1SG2277
ATOM 2277 N ASN 291 62 .509 42 .306 40, .301 1. .00 68. .40 1SG2278
ATOM 2278 CA ASN 291 61, .754 42, .345 41, .515 1. ,00 68. .40 1SG2279
ATOM 2279 CB ASN 291 61 .537 43, .764 42, .074 1. .00 68, .40 1SG2280
ATOM 2280 CG ASN 291 60 .788 44 .578 41, .037 1. .00 68, .40 1SG2281
ATOM 2281 ODl ASN 291 60 .855 44 .281 39, .846 1. .00 68, .40 1SG2282
ATOM 2282 ND2 ASN 291 60 .059 45 .632 41 .493 1, .00 68, .40 1SG2283
ATOM 2283 C ASN 291 60. .425 41, .718 41, .234 1. .00 68, .40 1SG2284
ATOM 2284 O ASN 291 60 .007 41, .611 40, .081 1. .00 68, .40 1SG2285
ATOM 2285 N SER 292 59 .745 41 .256 42. .303 1. .00 75, .31 1SG2286
ATOM 2286 CA SER 292 58 .466 40 .612 42, .198 1, .00 75, .31 1SG2287
ATOM 2287 CB SER 292 57, .951 40, .123 43, .560 1, .00 75, .31 1SG2288
ATOM 2288 OG SER 292 56 .687 39, .500 43. .404 1. .00 75. .31 1SG2289
ATOM 2289 C SER 292 57, .490 41, .615 41, .681 1. .00 75, .31 1SG2290
ATOM 2290 O SER 292 56 .684 41 .323 40, .799 1, .00 75, .31 1SG2291
ATOM 2291 N GLN 293 57 .573 42 .861 42 .189 1. .00 80, .40 1SG2292
ATOM 2292 CA GLN 293 56, .750 43, .900 41. .638 1. .00 80, .40 1SG2293
ATOM 2293 CB GLN 293 56, .860 45, .239 42, .385 1. .00 80, .40 1SG2294
ATOM 2294 CG GLN 293 56 .337 45 .193 43 , .821 1. .00 80, .40 1SG2295
ATOM 2295 CD GLN 293 56 .511 46 .579 44, .426 1, .00 80, .40 1SG2296
ATOM 2296 OEl GLN 293 56 .155 46 .819 45, .578 1. .00 80, .40 1SG2297
ATOM 2297 NE2 GLN 293 57, .079 47. .522 43 , .627 1. .00 80, .40 1SG2298
ATOM 2298 C GLN 293 57, .377 44, .082 40, .302 1. .00 80. .40 1SG2299
ATOM 2299 O GLN 293 58, .438 43 .564 40, .061 1. .00 80, .40 1SG2300
ATOM 2300 N GLY 294 56 .789 44 .716 39, .308 1. .00 78, .12 1SG2301
ATOM 2301 CA GLY 294 57, .595 44 , .784 38. .119 1. .00 78. .12 1SG2302
ATOM 2302 C GLY 294 57, .313 43 , .543 37. .330 1. .00 78. .12 1SG2303
ATOM 2303 O GLY 294 56, .699 43, .596 36. .271 1. .00 78. .12 1SG2304
ATOM 2304 N LEU 295 57, .726 42, .376 37. .865 1. .00 71, .39 1SG2305
ATOM 2305 CA LEU 295 57 .454 41 .096 37. .292 1. .00 71, .39 1SG2306
ATOM 2306 CB LEU 295 58, .132 39, .917 38. .009 1. .00 71. .39 1SG2307
ATOM 2307 CG LEU 295 57. .809 38, .563 37. .348 1. .00 71. .39 1SG2308
ATOM 2308 CD2 LEU 295 58, .303 37, .385 38. .201 1. .00 71. .39 1SG2309
ATOM 2309 CDl LEU 295 58, .336 38, .510 35. .907 1. .00 71. .39 1SG2310
ATOM 2310 C LEU 295 55. .990 40, .945 37. .452 1. .00 71. ,39 1SG2311
ATOM 2311 0 LEU 295 55. .334 40. .175 36. .755 1. .00 71. ,39 1SG2312
ATOM 2312 N GLY 296 55, .449 41, .690 38. .431 1. .00 63. .25 1SG2313
ATOM 2313 CA GLY 296 54, .053 41, .599 38, .741 1. .00 63. .25 1SG2314
ATOM 2314 C GLY 296 53, .230 41, .950 37. .544 1. .00 63. .25 1SG2315
ATOM 2315 O GLY 296 52. .135 41. .413 37. .374 1. ,00 63. ,25 1SG2316
ATOM 2316 N ASN 297 53. .685 42. .892 36. .696 1. ,00 60. ,80 1SG2317
ATOM 2317 CA ASN 297 52. .784 43. .208 35. .622 1. ,00 60. ,80 1SG2318
ATOM 2318 CB ASN 297 53. .215 44. .390 34. .725 1. .00 60. ,80 1SG2319
ATOM 2319 CG ASN 297 54. ,349 43. .998 33. ,787 1. .00 60. 80 1SG2320
ATOM 2320 ODl ASN 297 55. ,327 43. .354 34. .160 1. .00 60. ,80 1SG2321
ATOM 2321 ND2 ASN 297 54. ,203 44. .399 32. .496 1. ,00 60. ,80 1SG2322 ATOM 2322 C ASN 297 52..592 42..000 34 ,.747 1..00 60..80 1SG2323
ATOM 2323 O ASN 297 51. .470 41. .689 34. .347 1. ,00 60. .80 1SG2324
ATOM 2324 N VAL 298 53. .698 41. .318 34, .389 1. .00 65. .32 1SG2325
ATOM 2325 CA VAL 298 53, .628 40. .173 33, .521 1. .00 65. .32 1SG2326
ATOM 2326 CB VAL 298 54. .926 39. .917 32, .814 1. .00 65, .32 1SG2327
ATOM 2327 CGI VAL 298 54, .756 38. .681 31, .915 1. .00 65, .32 1SG2328
ATOM 2328 CG2 VAL 298 55, .337 41. .194 32, .059 1. .00 65, .32 1SG2329
ATOM 2329 C VAL 298 53, .217 38. .892 34, .206 1. .00 65, .32 1SG2330
ATOM 2330 O VAL 298 52. .391 38. .156 33 .666 1, .00 65, .32 1SG2331
ATOM 2331 N LEU 299 53, .796 38, .556 35, .389 1. .00 72, .73 1SG2332
ATOM 2332 CA LEU 299 53, .431 37 .271 35 .930 1, .00 72 .73 1SG2333
ATOM 2333 CB LEU 299 54, .510 36, .182 35. .788 1. .00 72, .73 1SG2334
ATOM 2334 CG LEU 299 55. .029 35. .948 34. .358 1. .00 72, .73 1SG2335
ATOM 2335 CD2 LEU 299 55. .542 34. .515 34. .175 1. .00 72, .73 1SG2336
ATOM 2336 CDl LEU 299 56. .061 37 .013 33. .958 1, .00 72 .73 1SG2337
ATOM 2337 C LEU 299 53, .169 37 .333 37 .403 1, .00 72 .73 1SG2338
ATOM 2338 O LEU 299 54, .080 37. .118 38, .201 1. .00 72 .73 1SG2339
ATOM 2339 N SER 300 51. .907 37, .548 37. .826 1. .00 77, .56 1SG2340
ATOM 2340 CA SER 300 51. .706 37, .562 39. .246 1, .00 77 .56 1SG2341
ATOM 2341 CB SER 300 51. .485 38 .977 39. .814 1, .00 77 .56 1SG2342
ATOM 2342 OG SER 300 50 .296 39 .547 39 .286 1 .00 77 .56 1SG2343
ATOM 2343 C SER 300 50. .515 36, .738 39. .634 1. .00 77. .56 1SG2344
ATOM 2344 O SER 300 49. ,372 37, .145 39. .425 1. .00 77 .56 1SG2345
ATOM 2345 N ARG 301 50. .741 35, .525 40, .184 1. .00 73 .81 1SG2346
ATOM 2346 CA ARG 301 52 .030 34 .900 40, .243 1. .00 73 .81 1SG2347
ATOM 2347 CB ARG 301 52. .733 34, .820 38, .878 1, .00 73 .81 1SG2348
ATOM 2348 CG ARG 301 51. .891 34 , .108 37. .817 1. .00 73. .81 1SG2349
ATOM 2349 CD ARG 301 50, .717 34, .945 37. .304 1. .00 73 .81 1SG2350
ATOM 2350 NE ARG 301 49 .931 34 .098 36. .363 1. .00 73 .81 1SG2351
ATOM 2351 CZ ARG 301 48, .937 33 , .295 36. .844 1, .00 73 .81 1SG2352
ATOM 2352 NHl ARG 301 48, .662 33 .274 38. .181 1. .00 73 .81 1SG2353
ATOM 2353 NH2 ARG 301 48, .214 32 , .516 35. .987 1. .00 73. .81 1SG2354
ATOM 2354 C ARG 301 52, .968 35, .506 41. .242 1. .00 73 .81 1SG2355
ATOM 2355 O ARG 301 52. .652 35, .653 42. .421 1. .00 73 .81 1SG2356
ATOM 2356 N ILE 302 54, .176 35, .874 40. .759 1. .00 62 .51 1SG2357
ATOM 2357 CA ILE 302 55, .275 36 .289 41. .587 1, .00 62 .51 1SG2358
ATOM 2358 CB ILE 302 56, .471 36. .758 40. .809 1. .00 62 .51 1SG2359
ATOM 2359 CG2 ILE 302 56. .092 38. .042 40. .053 1. .00 62 .51 1SG2360
ATOM 2360 CGI ILE 302 57. .675 36. .914 41. .756 1. .00 62. .51 1SG2361
ATOM 2361 CDl ILE 302 59. .017 37. .067 41. .043 1. .00 62 .51 1SG2362
ATOM 2362 C ILE 302 54, .880 37 .385 42. .520 1. .00 62 .51 1SG2363
ATOM 2363 O ILE 302 55, .266 37. .362 43. .687 1. ,00 62. .51 1SG2364
ATOM 2364 N ALA 303 54. .128 38. .393 42. .056 1. ,00 49, .72 1SG2365
ATOM 2365 CA ALA 303 53. .757 39. .410 42. ,993 1. ,00 49, .72 1SG2366
ATOM 2366 CB ALA 303 52, .985 40. .570 42. .342 1. .00 49, .72 1SG2367
ATOM 2367 C ALA 303 52, .870 38. .806 44. .039 1. .00 49 .72 1SG2368
ATOM 2368 O ALA 303 53. .052 39. .053 45. .229 1. .00 49, .72 1SG2369
ATOM 2369 N GLU 304 51. .882 37. .995 43. ,614 1. .00 41. .47 1SG2370
ATOM 2370 CA GLU 304 50. .917 37. .460 44. ,536 1. .00 41, .47 1SG2371
ATOM 2371 CB GLU 304 49, .763 36. .740 43. .818 1. .00 41, .47 1SG2372
ATOM 2372 CG GLU 304 48 , .897 37. .681 42. .978 1. .00 41 .47 1SG2373
ATOM 2373 CD GLU 304 47. .799 36. ,856 42. 323 1. 00 41. .47 1SG2374
ATOM 2374 OEl GLU 304 47. .770 35. ,619 42. .558 1. .00 41. .47 1SG2375
ATOM 2375 OE2 GLU 304 46. .976 37. .452 41. ,578 1. .00 41, .47 1SG2376
ATOM 2376 C GLU 304 51. .520 36. .485 45. ,502 1. .00 41, .47 1SG2377
ATOM 2377 O GLU 304 51. .377 36. .639 46. ,714 1. .00 41, .47 1SG2378
ATOM 2378 N ILE 305 52. .214 35. ,448 44. 994 1. 00 38. .85 1SG2379 ATOM 2379 CA ILE 305 52..754 34..436 45,.857 1..00 38..85 1SG2380
ATOM 2380 CB ILE 305 53. .348 33. .286 45. .097 1. .00 38, .85 1SG2381
ATOM 2381 CG2 ILE 305 54. .017 32. .346 46. .112 1. .00 38, .85 1SG2382
ATOM 2382 CGI ILE 305 52. .275 32. .599 44. .236 1. .00 38. .85 1SG2383
ATOM 2383 CDl ILE 305 51, .119 32. .019 45, ,049 1, .00 38 .85 1SG2384
ATOM 2384 C ILE 305 53, .847 35. .030 46. .671 1. .00 38, .85 1SG2385
ATOM 2385 O ILE 305 53. .893 34. .876 47. .891 1. .00 38, .85 1SG2386
ATOM 2386 N TYR 306 54. .763 35. .746 46. .001 1. .00 42 .40 1SG2387
ATOM 2387 CA TYR 306 55. .842 36, .322 46. .727 1. .00 42 .40 1SG2388
ATOM 2388 CB TYR 306 57. .185 36. .163 45. .996 1. .00 42. .40 1SG2389
ATOM 2389 CG TYR 306 57, .349 34, .706 45. .728 1, .00 42 .40 1SG2390
ATOM 2390 CDl TYR 306 57, .846 33. .852 46. .686 1. .00 42, .40 1SG2391
ATOM 2391 CD2 TYR 306 56, .991 34. .195 44, .502 1, .00 42 .40 1SG2392
ATOM 2392 CE1 TYR 306 57, .985 32, .509 46, .420 1. .00 42 .40 1SG2393
ATOM 2393 CE2 TYR 306 57, .128 32 , .855 44. .229 1. .00 42, .40 1SG2394
ATOM 2394 CZ TYR 306 57, .626 32, .010 45. .190 1, .00 42 .40 1SG2395
ATOM 2395 OH TYR 306 57, .765 30, .634 44, .910 1. .00 42 .40 1SG2396
ATOM 2396 C TYR 306 55. .536 37, .773 46 , .777 1, .00 42 .40 1SG2397
ATOM 2397 O TYR 306 56, .034 38, .551 45, .962 1. .00 42 .40 1SG2398
ATOM 2398 N ILE 307 54 , .723 38, .180 47, .774 1, .00 48 .68 1SG2399
ATOM 2399 CA ILE 307 54. .406 39, .569 47. .897 1, .00 48 .68 1SG2400
ATOM 2400 CB ILE 307 53. .092 39, .814 48. .589 1. .00 48 .68 1SG2401
ATOM 2401 CG2 ILE 307 51, .965 39, .206 47. .740 1. .00 48 .68 1SG2402
ATOM 2402 CGI ILE 307 53. .130 39. .270 50. .028 1. .00 48 .68 1SG2403
ATOM 2403 CDl ILE 307 51. .964 39. .750 50, .891 1. .00 48 .68 1SG2404
ATOM 2404 C ILE 307 55, .464 40. .106 48, .785 1. .00 48 .68 1SG2405
ATOM 2405 O ILE 307 55, .251 40. .962 49, .637 1, .00 48 .68 1SG2406
ATOM 2406 N LEU 308 56. .682 39, .623 48, .551 1. .00 54 .02 1SG2407
ATOM 2407 CA LEU 308 57. .801 40, .061 49. .291 1. .00 54 .02 1SG2408
ATOM 2408 CB LEU 308 59. .077 39 .308 48. .895 1. .00 54 .02 1SG2409
ATOM 2409 CG LEU 308 59. .083 37, .827 49, .307 1. .00 54 .02 1SG2410
ATOM 2410 CD2 LEU 308 60. .421 37, .169 48. .942 1, .00 54 .02 1SG2411
ATOM 2411 CDl LEU 308 57. .888 37. .070 48. .713 1, .00 54 .02 1SG2412
ATOM 2412 C LEU 308 57, .975 41, .478 48, .909 1, .00 54 .02 1SG2413
ATOM 2413 O LEU 308 58, .476 42, .275 49. .700 1. .00 54 .02 1SG2414
ATOM 2414 N SER 309 57, .571 41, .804 47. .658 1. .00 59 .89 1SG2415
ATOM 2415 CA SER 309 57, .886 43. .075 47, .087 1, .00 59 .89 1SG2416
ATOM 2416 CB SER 309 57. .245 44. .312 47, .764 1. .00 59 .89 1SG2417
ATOM 2417 OG SER 309 57, .887 44. .663 48, .980 1, .00 59 .89 1SG2418
ATOM 2418 C SER 309 59. .364 43. .078 47, .234 1. .00 59 .89 1SG2419
ATOM 2419 O SER 309 59. .997 44. .056 47, .626 1. .00 59, .89 1SG2420
ATOM 2420 N GLN 310 59. .935 41, .893 46, .939 1. .00 61 .52 1SG2421
ATOM 2421 CA GLN 310 61. .332 41. .663 47, .093 1. .00 61, .52 1SG2422
ATOM 2422 CB GLN 310 61, .703 40, .445 47. .957 1, .00 61, .52 1SG2423
ATOM 2423 CG GLN 310 61. .596 40, .715 49, .461 1. .00 61, .52 1SG2424
ATOM 2424 CD GLN 310 62. .740 41, .636 49. .861 1. .00 61, .52 1SG2425
ATOM 2425 OEl GLN 310 63. .892 41, .411 49, .494 1, .00 61 .52 1SG2426
ATOM 2426 NE2 GLN 310 62. .416 42, .708 50. .633 1. .00 61, .52 1SG2427
ATOM 2427 C GLN 310 61. .942 41. .489 45. .759 1. .00 61, .52 1SG2428
ATOM 2428 O GLN 310 61. .292 41. .427 44 , .715 1. .00 61, .52 1SG2429
ATOM 2429 N PRO 311 63. .235 41, .487 45. .843 1. .00 59, .37 1SG2430
ATOM 2430 CA PRO 311 64. ,014 41. .361 44. .653 1. .00 59, .37 1SG2431
ATOM 2431 CD PRO 311 63. .882 42. .346 46. .824 1. .00 59, .37 1SG2432
ATOM 2432 CB PRO 311 65. .404 41. .889 44. .998 1. .00 59, .37 1SG2433
ATOM 2433 CG PRO 311 65. .140 42. ,892 46. ,133 1. .00 59. .37 1SG2434
ATOM 2434 C PRO 311 64. .030 39. ,964 44. .158 1. .00 59. .37 1SG2435
ATOM 2435 O PRO 311 63. .761 39. .044 44. .929 1. .00 59. .37 1SG2436 ATOM 2436 N PHE 312 64,.322 39..778 42..861 1..00 54..44 1SG2437
ATOM 2437 CA PHE 312 64, .457 38, .430 42, .431 1. .00 54. .44 1SG2438
ATOM 2438 CB PHE 312 63 .413 37, .891 41, .424 1. .00 54, .44 1SG2439
ATOM 2439 CG PHE 312 63, .491 38 .517 40, .076 1. .00 54, .44 1SG2440
ATOM 2440 CDl PHE 312 64, .516 38, .202 39, .215 1. .00 54, .44 1SG2441
ATOM 2441 CD2 PHE 312 62 .503 39, .375 39, .655 1. .00 54, .44 1SG2442
ATOM 2442 CE1 PHE 312 64, .574 38, .766 37, .962 1. .00 54, .44 1SG2443
ATOM 2443 CE2 PHE 312 62 .553 39, .941 38. .403 1. .00 54, .44 1SG2444
ATOM 2444 CZ PHE 312 63. .593 39, .640 37. .557 1. .00 54, .44 1SG2445
ATOM 2445 C PHE 312 65. .830 38, .305 41. .889 1. .00 54, .44 1SG2446
ATOM 2446 O PHE 312 66 .379 39. .267 41. .357 1. .00 54, .44 1SG2447
ATOM 2447 N MET 313 66 .439 37. .119 42 .070 1. .00 46, .45 1SG2448
ATOM 2448 CA MET 313 67. .780 36. .911 41. .621 1. .00 46 .45 1SG2449
ATOM 2449 CB MET 313 68 .725 36. .404 42. .724 1. .00 46, .45 1SG2450
ATOM 2450 CG MET 313 70 .163 36 .191 42 .247 1, .00 46 .45 1SG2451
ATOM 2451 SD MET 313 71 .314 35 .638 43 .542 1. .00 46 .45 1SG2452
ATOM 2452 CE MET 313 71 .433 37. .259 44 .352 1. .00 46 .45 1SG2453
ATOM 2453 C MET 313 67. .729 35. .876 40, .549 1. ,00 46, .45 1SG2454
ATOM 2454 o MET 313 66, .938 34. .936 40, .621 1. .00 46, .45 1SG2455
ATOM 2455 N VAL 314 68 .570 36. .038 39, .508 1. .00 40 .82 1SG2456
ATOM 2456 CA VAL 314 68, .547 35, .096 38 .429 1, .00 40 .82 1SG2457
ATOM 2457 CB VAL 314 68, .279 35, .730 37, .095 1, .00 40, .82 1SG2458
ATOM 2458 CGI VAL 314 69 .436 36, .686 36, .770 1. .00 40 .82 1SG2459
ATOM 2459 CG2 VAL 314 68 .088 34, .618 36 .049 1. .00 40 .82 1SG2460
ATOM 2460 C VAL 314 69 .884 34 .434 38 .341 1. .00 40 .82 1SG2461
ATOM 2461 O VAL 314 70 .923 35, .071 38 .508 1. .00 40 .82 1SG2462
ATOM 2462 N ARG 315 69 .882 33 .112 38 .072 1. .00 36 .38 1SG2463
ATOM 2463 CA ARG 315 71 .115 32 .393 37 .958 1, .00 36 .38 1SG2464
ATOM 2464 CB ARG 315 71 .161 31, .098 38 .786 1, .00 36 .38 1SG2465
ATOM 2465 CG ARG 315 71, .126 31. .335 40, .296 1. .00 36 .38 1SG2466
ATOM 2466 CD ARG 315 71 .246 30. .049 41, .116 1. .00 36 .38 1SG2467
ATOM 2467 NE ARG 315 70 .043 29. .218 40, .829 1. .00 36 .38 1SG2468
ATOM 2468 CZ ARG 315 69 .950 27 .955 41 .340 1. .00 36 .38 1SG2469
ATOM 2469 NHl ARG 315 70. .961 27, .451 42, .105 1, .00 36 .38 1SG2470
ATOM 2470 NH2 ARG 315 68 .843 27. .197 41 .087 1. .00 36, .38 1SG2471
ATOM 2471 C ARG 315 71 .271 32, .002 36 .526 1. .00 36 .38 1SG2472
ATOM 2472 O ARG 315 70 .353 31 .463 35 .909 1. .00 36 .38 1SG2473
ATOM 2473 N ILE 316 72 .457 32, .281 35 .955 1 .00 33 .38 1SG2474
ATOM 2474 CA ILE 316 72 .674 31 .959 34 .578 1. .00 33 .38 1SG2475
ATOM 2475 CB ILE 316 73 .085 33 .159 33 .776 1. .00 33 .38 1SG2476
ATOM 2476 CG2 ILE 316 73, .196 32, .733 32, .302 1. .00 33 .38 1SG2477
ATOM 2477 CGI ILE 316 72, .108 34, .323 34 .022 1. .00 33 .38 1SG2478
ATOM 2478 CDl ILE 316 70, .640 33. .979 33, .782 1. .00 33. .38 1SG2479
ATOM 2479 C ILE 316 73, .817 30, .997 34, .528 1. .00 33, .38 1SG2480
ATOM 2480 O ILE 316 74 .914 31, .308 34, .989 1. .00 33 .38 1SG2481
ATOM 2481 N MET 317 73, .596 29 .792 33 .967 1, .00 31 .68 1SG2482
ATOM 2482 CA MET 317 74, .682 28, .859 33, .877 1. .00 31, .68 1SG2483
ATOM 2483 CB MET 317 74, .649 27, .736 34, .930 1. .00 31, .68 1SG2484
ATOM 2484 CG MET 317 73 .534 26, .706 34 .737 1. .00 31 .68 1SG2485
ATOM 2485 SD MET 317 73 .546 25 .371 35 .973 1, .00 31 .68 1SG2486
ATOM 2486 CE MET 317 72, .119 24, .475 35, .297 1, .00 31 .68 1SG2487
ATOM 2487 C MET 317 74 , .621 28. .217 32, .530 1. .00 31. .68 1SG2488
ATOM 2488 O MET 317 73, .601 28. .282 31. .846 1. .00 31. .68 1SG2489
ATOM 2489 N ALA 318 75, .735 27. .588 32. .106 1. .00 31. .33 1SG2490
ATOM 2490 CA ALA 318 75. .747 26. .940 30. .827 1. .00 31, .33 1SG2491
ATOM 2491 CB ALA 318 77, .136 26. .895 30. .167 1. ,00 31. .33 1SG2492
ATOM 2492 C ALA 318 75, .300 25. .532 31, .045 1. ,00 31. .33 1SG2493 ATOM 2493 O ALA 318 75,.814 24..841 31..923 1..00 31..33 1SG2494
ATOM 2494 N THR 319 74. .279 25. .098 30. .276 1. .00 34. .22 1SG2495
ATOM 2495 CA THR 319 73. .758 23. .765 30. .400 1. .00 34. .22 1SG2496
ATOM 2496 CB THR 319 72. .468 23. .571 29. .657 1. .00 34. .22 1SG2497
ATOM 2497 OGl THR 319 72. .673 23. .709 28. .258 1. .00 34. .22 1SG2498
ATOM 2498 CG2 THR 319 71. .472 24. .632 30, .150 1. .00 34. .22 1SG2499
ATOM 2499 C THR 319 74 , .737 22, .769 29. .857 1. .00 34. .22 1SG2500
ATOM 2500 O THR 319 74. .994 21, .736 30, .475 1, .00 34. .22 1SG2501
ATOM 2501 N GLU 320 75, .311 23, .061 28, .673 1. .00 38. .83 1SG2502
ATOM 2502 CA GLU 320 76, .214 22. .136 28. .047 1. .00 38. .83 1SG2503
ATOM 2503 CB GLU 320 75. .575 21. .376 26, .870 1. .00 38. .83 1SG2504
ATOM 2504 CG GLU 320 75. .092 22, .279 25, .730 1. .00 38. .83 1SG2505
ATOM 2505 CD GLU 320 74 .323 21 .413 24, .738 • 1. .00 38, .83 1SG2506
ATOM 2506 OEl GLU 320 73, .672 20, .435 25, .193 1. .00 38, .83 1SG2507
ATOM 2507 OE2 GLU 320 74 , .372 21. .717 23. .516 1. .00 38. .83 1SG2508
ATOM 2508 C GLU 320 77, .372 22. .926 27, .526 1, .00 38. .83 1SG2509
ATOM 2509 O GLU 320 77, .361 24 , .153 27, .570 1. .00 38. .83 1SG2510
ATOM 2510 N PRO 321 78 .396 22 .259 27 .061 1, .00 43 .00 1SG2511
ATOM 2511 CA PRO 321 79. .545 22. .955 26, .551 1, .00 43. .00 1SG2512
ATOM 2512 CD PRO 321 78, .730 20. .921 27, .513 1. .00 43. .00 1SG2513
ATOM 2513 CB PRO 321 80, .662 21. .915 26. .438 1, .00 43, .00 1SG2514
ATOM 2514 CG PRO 321 79, .962 20. .560 26, .669 1, .00 43, .00 1SG2515
ATOM 2515 C PRO 321 79, .222 23 .660 25, .276 1, .00 43, .00 1SG2516
ATOM 2516 O PRO 321 78, .602 23, .064 24. .398 1. .00 43, .00 1SG2517
ATOM 2517 N PRO 322 79, .660 24, .879 25. .150 1. .00 45. .54 1SG2518
ATOM 2518 CA PRO 322 79, .370 25 .611 23. .951 1, .00 45. .54 1SG2519
ATOM 2519 CD PRO 322 79, .731 25, .754 26. .310 1. .00 45. .54 1SG2520
ATOM 2520 CB PRO 322 79 .696 27 .066 24. .267 1, .00 45 .54 1SG2521
ATOM 2521 CG PRO 322 79, .436 27, .167 25, .780 1, .00 45. .54 1SG2522
ATOM 2522 C PRO 322 80, .107 25, .052 22. .777 1, .00 45, .54 1SG2523
ATOM 2523 O PRO 322 81. .228 24 .574 22, .940 1, .00 45, .54 1SG2524
ATOM 2524 N ILE 323 79. .501 25, .112 21, .577 1, .00 44, .40 1SG2525
ATOM 2525 CA ILE 323 80. .138 24 .555 20, .420 1 .00 44, .40 1SG2526
ATOM 2526 CB ILE 323 79, .261 23, .640 19, .613 1, .00 44, .40 1SG2527
ATOM 2527 CG2 ILE 323 80, .064 23. .215 18. .371 1, .00 44, .40 1SG2528
ATOM 2528 CGI ILE 323 78, .764 22. .454 20, .455 1, .00 44, .40 1SG2529
ATOM 2529 CDl ILE 323 79, .883 21. .560 20. .982 1, .00 44, .40 1SG2530
ATOM 2530 C ILE 323 80. .486 25 .681 19. .505 1 .00 44. .40 1SG2531
ATOM 2531 O ILE 323 79, .753 26. .662 19, .409 1, .00 44. .40 1SG2532
ATOM 2532 N ILE 324 81. .652 25. .577 18. ,837 1, .00 43. .93 1SG2533
ATOM 2533 CA ILE 324 82. .070 26. .566 17. .886 1, .00 43. .93 1SG2534
ATOM 2534 CB ILE 324 83. .366 27, .238 18. .240 1, .00 43. .93 1SG2535
ATOM 2535 CG2 ILE 324 83. .788 28 .116 17. .049 1, .00 43. .93 1SG2536
ATOM 2536 CGI ILE 324 83. .244 28, .008 19, .564 1, .00 43. .93 1SG2537
ATOM 2537 CDl ILE 324 84. .595 28. .432 20, .140 1, .00 43. .93 1SG2538
ATOM 2538 C ILE 324 82. .327 25. .838 16, .607 1, .00 43, .93 1SG2539
ATOM 2539 O ILE 324 83. .056 24. .848 16. .585 1, .00 43. .93 1SG2540
ATOM 2540 N ASN 325 81. .730 26, .297 15, .492 1, .00 48, .74 1SG2541
ATOM 2541 CA ASN 325 82. .025 25, .617 14 , .268 1, .00 48. .74 1SG2542
ATOM 2542 CB ASN 325 80. .845 24. .839 13. .647 1, .00 48. .74 1SG2543
ATOM 2543 CG ASN 325 79. .596 25. .695 13. .625 1, .00 48. .74 1SG2544
ATOM 2544 ODl ASN 325 79. .191 26. .197 14. .672 1, .00 48. .74 1SG2545
ATOM 2545 ND2 ASN 325 78. .953 25, .827 12. .434 1, .00 48. .74 1SG2546
ATOM 2546 C ASN 325 82. .661 26. .559 13. .305 1, .00 48. .74 1SG2547
ATOM 2547 0 ASN 325 82. ,242 27. .706 13. .152 1. .00 48. .74 1SG2548
ATOM 2548 N LEU 326 83. .743 26. .093 12. .648 1. .00 54. .50 1SG2549
ATOM 2549 CA LEU 326 84. .420 26. ,988 11. .763 1. .00 54. ,50 1SG2550 ATOM 2550 CB LEU 326 85.921 27..140 12.,039 1.,00 54..50 1SG2551
ATOM 2551 CG LEU 326 86. .491 28. ,279 11. ,187 1. ,00 54. ,50 1SG2552
ATOM 2552 CD2 LEU 326 88. .007 28. .433 11. .342 1. .00 54. .50 1SG2553
ATOM 2553 CDl LEU 326 85. ,741 29. .581 11. .499 1. .00 54. .50 1SG2554
ATOM 2554 C LEU 326 84. ,245 26. .537 10. .349 1. .00 54. .50 1SG2555
ATOM 2555 O LEU 326 84. .469 25. .375 10. .014 1. .00 54, .50 1SG2556
ATOM 2556 N GLN 327 83. .811 27. .471 9, .478 1. .00 63, .27 1SG2557
ATOM 2557 CA GLN 327 83. ,643 27. .187 8. .083 1. .00 63. .27 1SG2558
ATOM 2558 CB GLN 327 82. ,197 26. .871 7. .659 1. .00 63. .27 1SG2559
ATOM 2559 CG GLN 327 81. .625 25. .586 8. .264 1. .00 63, .27 1SG2560
ATOM 2560 CD GLN 327 80. .804 25. .940 9. .498 1. .00 63. .27 1SG2561
ATOM 2561 OEl GLN 327 80. .302 27. .053 9. .646 1. .00 63, .27 1SG2562
ATOM 2562 NE2 GLN 327 80. .649 24. .946 10. .412 1. .00 63, .27 1SG2563
ATOM 2563 C GLN 327 84. .028 28. .429 7, .361 1. .00 63, .27 1SG2564
ATOM 2564 O GLN 327 83. .931 29. .510 7. .936 1. .00 63, .27 1SG2565
ATOM 2565 N PRO 328 84. .476 28. .300 6. .132 1. .00 68, .64 1SG2566
ATOM 2566 CA PRO 328 84. .866 29. .443 5. .351 1. .00 68, .64 1SG2567
ATOM 2567 CD PRO 328 84, .082 27, .181 5. .291 1, .00 68 .64 1SG2568
ATOM 2568 CB PRO 328 85. .131 28. .910 3 , .947 1. .00 68, .64 1SG2569
ATOM 2569 CG PRO 328 84. .161 27. .717 3. .850 1. .00 68, .64 1SG2570
ATOM 2570 C PRO 328 83. .692 30, .351 5 .367 1, .00 68 .64 1SG2571
ATOM 2571 O PRO 328 82, .606 29, .902 5. .034 1, .00 68 .64 1SG2572
ATOM 2572 N GLY 329 83, .870 31. .625 5. .729 1, .00 66 .67 1SG2573
ATOM 2573 CA GLY 329 82. .742 32. .495 5. .818 1, .00 66 .67 1SG2574
ATOM 2574 C GLY 329 82, .655 32, .977 7 .228 1, .00 66 .67 1SG2575
ATOM 2575 O GLY 329 82, .452 34, .171 7, .438 1, .00 66 .67 1SG2576
ATOM 2576 N ASN 330 82, .815 32 , .084 8, .236 1. .00 62 .98 1SG2577
ATOM 2577 CA ASN 330 82. .764 32. .607 9, .574 1, .00 62 .98 1SG2578
ATOM 2578 CB ASN 330 81. .485 33. .408 9 .877 1 .00 62 .98 1SG2579
ATOM 2579 CG ASN 330 80, .308 32, .449 9 .753 1, .00 62 .98 1SG2580
ATOM 2580 ODl ASN 330 80. .199 31, .704 8, .780 1, .00 62 .98 1SG2581
ATOM 2581 ND2 ASN 330 79. .405 32. .458 10, .770 1, .00 62 .98 1SG2582
ATOM 2582 C ASN 330 82, .767 31. .516 10 .600 1, .00 62 .98 1SG2583
ATOM 2583 O ASN 330 82, .594 30. .337 10 .300 1, .00 62 .98 1SG2584
ATOM 2584 N PHE 331 82, .946 31. .938 11, .871 1, .00 55 .75 1SG2585
ATOM 2585 CA PHE 331 82. .874 31. .091 13, .030 1. .00 55 .75 1SG2586
ATOM 2586 CB PHE 331 83. .809 31. .486 14 .188 1, .00 55 .75 1SG2587
ATOM 2587 CG PHE 331 85. .221 31. .085 13 .971 1, .00 55 .75 1SG2588
ATOM 2588 CDl PHE 331 86. .100 31. .922 13. .327 1, .00 55 .75 1SG2589
ATOM 2589 CD2 PHE 331 85 .664 29, .865 14 .429 1 .00 55 .75 1SG2590
ATOM 2590 CE1 PHE 331 87. .406 31, .540 13 .139 1, .00 55 .75 1SG2591
ATOM 2591 CE2 PHE 331 86. .969 29, .479 14, .243 1, .00 55 .75 1SG2592
ATOM 2592 CZ PHE 331 87. .842 30, .321 13, .596 1. .00 55 .75 1SG2593
ATOM 2593 C PHE 331 81 .530 31, .336 13 .633 1, .00 55 .75 1SG2594
ATOM 2594 O PHE 331 81. .101 32, .480 13 .776 1, .00 55 .75 1SG2595
ATOM 2595 N THR 332 80. .829 30, .258 14, .019 1. .00 51 .24 1SG2596
ATOM 2596 CA THR 332 79. .552 30. .433 14. .638 1. .00 51, .24 1SG2597
ATOM 2597 CB THR 332 78. .436 29, .979 13 .743 1. .00 51 .24 1SG2598
ATOM 2598 OGl THR 332 77, .178 30, .154 14. .369 1, .00 51 .24 1SG2599
ATOM 2599 CG2 THR 332 78, .665 28, .524 13. .339 1. .00 51 .24 1SG2600
ATOM 2600 C THR 332 79. .569 29. .676 15. .931 1. .00 51, .24 1SG2601
ATOM 2601 O THR 332 80. .149 28. .595 16 .017 1. .00 51 .24 1SG2602
ATOM 2602 N LEU 333 78. .961 30, .257 16, .991 1. .00 49, .05 1SG2603
ATOM 2603 CA LEU 333 78. .964 29. .613 18, .275 1. .00 49, .05 1SG2604
ATOM 2604 CB LEU 333 79. .683 30. .413 19 .374 1, .00 49 .05 1SG2605
ATOM 2605 CG LEU 333 81. .212 30, .365 19, .202 1. .00 49 .05 1SG2606
ATOM 2606 CD2 LEU 333 81. .930 31. .079 20, .359 1. .00 49. .05 1SG2607 ATOM 2607 CDl LEU 333 81,.631 30,.876 17,.816 1..00 49,.05 1SG2608
ATOM 2608 C LEU 333 77. .564 29, .322 18, .712 1, .00 49, .05 1SG2609
ATOM 2609 0 LEU 333 76. .635 30, .074 18, .424 1, .00 49. .05 1SG2610
ATOM 2610 N ASP 334 77. .390 28, .178 19, .411 1. .00 46. .43 1SG2611
ATOM 2611 CA ASP 334 76. .096 27, .766 19, .880 1, .00 46. .43 1SG2612
ATOM 2612 CB ASP 334 75. .713 26, .359 19, .387 1, .00 46. .43 1SG2613
ATOM 2613 CG ASP 334 74. .251 26, .100 19 .716 1. .00 46. .43 1SG2614
ATOM 2614 ODl ASP 334 73, .617 26. .989 20, .343 1. .00 46. .43 1SG2615
ATOM 2615 OD2 ASP 334. 73, .749 25. .005 19, .343 1 , .00 46. .43 1SG2616
ATOM 2616 C ASP 334 76, .137 27, .718 21, .381 1. .00 46. .43 1SG2617
ATOM 2617 0 ASP 334 76, .671 26, .781 21. .968 1. .00 46. .43 1SG2618
ATOM 2618 N ILE 335 75, .552 28, .725 22. .057 1. .00 44. .55 1SG2619
ATOM 2619 CA ILE 335 75, .615 28, .765 23, .493 1. .00 44. .55 1SG2620
ATOM 2620 CB ILE 335 75, .976 30, .135 23, .995 1. .00 44. .55 1SG2621
ATOM 2621 CG2 ILE 335 76, .013 30, .078 25. .531 1. .00 44. .55 1SG2622
ATOM 2622 CGI ILE 335 77, .280 30, .641 23. .356 1. .00 44. .55 1SG2623
ATOM 2623 CDl ILE 335 78, .498 29, .773 23 .647 1. .00 44. .55 1SG2624
ATOM 2624 C ILE 335 74, .247 28, .497 24. .046 1. .00 44. .55 1SG2625
ATOM 2625 O ILE 335 73, .293 29. .194 23. .704 1. .00 44. .55 1SG2626
ATOM 2626 N PRO 336 74, .122 27. .440 24, .818 1. .00 40. .62 1SG2627
ATOM 2627 CA PRO 336 72. .895 27. .182 25, .534 1. .00 40, .62 1SG2628
ATOM 2628 CD PRO 336 74, .791 26. .209 24, .438 1. .00 40. .62 1SG2629
ATOM 2629 CB PRO 336 72 .698 25 .668 25 .513 1. .00 40 .62 1SG2630
ATOM 2630 CG PRO 336 74 .110 25 .113 25 .270 1. .00 40. .62 1SG2631
ATOM 2631 C PRO 336 73 .041 27, .715 26 .928 1. .00 40. .62 1SG2632
ATOM 2632 0 PRO 336 74 .161 27 .738 27 .438 1. .00 40 .62 1SG2633
ATOM 2633 N ALA 337 71 .939 28 .104 27 .594 1. .00 35 .88 1SG2634
ATOM 2634 CA ALA 337 72 .103 28, .558 28 .944 1, .00 35. .88 1SG2635
ATOM 2635 CB ALA 337 72 .359 30. .071 29 .060 1. .00 35 .88 1SG2636
ATOM 2636 C ALA 337 70 .840 28. .273 29 .682 1. .00 35. .88 1SG2637
ATOM 2637 0 ALA 337 69 .757 28, .250 29 .099 1, .00 35, .88 1SG2638
ATOM 2638 N SER 338 70 .958 28, .039 31 .004 1. .00 34, .04 1SG2639
ATOM 2639 CA SER 338 69, .786 27, .849 31 .801 1. .00 34 , .04 1SG2640
ATOM 2640 CB SER 338 69, .844 26, .677 32 .795 1, .00 34, .04 1SG2641
ATOM 2641 OG SER 338 69, .669 25, .444 32 .114 1, .00 34, .04 1SG2642
ATOM 2642 C SER 338 69, .649 29, .088 32, .609 1. .00 34, .04 1SG2643
ATOM 2643 0 SER 338 70, .603 29, .545 33, .239 1. .00 34 , .04 1SG2644
ATOM 2644 N ILE 339 68, .444 29, .677 32. .594 1. .00 35, .74 1SG2645
ATOM 2645 CA ILE 339 68, .241 30. .881 33. .332 1. .00 35. .74 1SG2646
ATOM 2646 CB ILE 339 67, .665 31. .983 32, .489 1. .00 35. .74 1SG2647
ATOM 2647 CG2 ILE 339 67, .596 33. .251 33, .356 1. .00 35. .74 1SG2648
ATOM 2648 CGI ILE 339 68, .470 32. .160 31, .186 1. .00 35. .74 1SG2649
ATOM 2649 CDl ILE 339 69. .961 32. .424 31. .378 1. .00 35. .74 1SG2650
ATOM 2650 C ILE 339 67. .200 30. .545 34. .349 1. .00 35. .74 1SG2651
ATOM 2651 0 ILE 339 66. .096 30. .131 33. .998 1. .00 35. .74 1SG2652
ATOM 2652 N MET 340 67. .526 30. .711 35. .644 1. .00 39, .23 1SG2653
ATOM 2653 CA MET 340 66, .591 30. .385 36. .684 1. .00 39, .23 1SG2654
ATOM 2654 CB MET 340 67, .197 29. .483 37, .773 1, .00 39. .23 1SG2655
ATOM 2655 CG MET 340 67, .657 28. .107 37, .289 1. .00 39. .23 1SG2656
ATOM 2656 SD MET 340 66. .321 26, .909 37, .019 1. .00 39. .23 1SG2657
ATOM 2657 CE MET 340 66, .026 26. .604 38. .785 1. .00 39. .23 1SG2658
ATOM 2658 C MET 340 66, .255 31. .666 37. .380 1. .00 39. .23 1SG2659
ATOM 2659 0 MET 340 67, .123 32. .506 37, .609 1. .00 39. .23 1SG2660
ATOM 2660 N MET 341 64, .973 31. .854 37. .740 1. .00 44. .32 1SG2661
ATOM 2661 CA MET 341 64. .614 33. .050 38. .440 1. ,00 44. .32 1SG2662
ATOM 2662 CB MET 341 63. .441 33. .810 37. .798 1. .00 44. .32 1SG2663
ATOM 2663 CG MET 341 63. .128 35. ,147 38. .471 1. ,00 44. ,32 1SG2664 ATOM 2664 SD MET 341 61..780 36..078 37.,683 1.00 44..32 1SG2665
ATOM 2665 CE MET 341 62, .740 36. .503 36. .201 1. .00 44. .32 1SG2666
ATOM 2666 C MET 341 64, .237 32. .640 39. .820 1. ,00 44. .32 1SG2667
ATOM 2667 O MET 341 63, .577 31. .623 40. .032 1. ,00 44. ,32 1SG2668
ATOM 2668 N LEU 342 64. .693 33. .433 40. .804 1. ,00 49. ,20 1SG2669
ATOM 2669 CA LEU 342 64. .511 33. .090 42. .176 1. .00 49. .20 1SG2670
ATOM 2670 CB LEU 342 65. .869 32. .887 42. .839 1. ,00 49. .20 1SG2671
ATOM 2671 CG LEU 342 65, .741 32. .186 44. .173 1. ,00 49. .20 1SG2672
ATOM 2672 CD2 LEU 342 67, .046 32. .258 44. .982 1. ,00 49. .20 1SG2673
ATOM 2673 CDl LEU 342 65, .227 30. .773 43. .884 1. .00 49. .20 1SG2674
ATOM 2674 C LEU 342 63, .910 34, .272 42. .863 1. .00 49. .20 1SG2675
ATOM 2675 O LEU 342 64, .166 35, .412 42. .482 1. .00 49. .20 1SG2676
ATOM 2676 N THR 343 63, .097 34. .027 43. .909 1. ,00 51. .24 1SG2677
ATOM 2677 CA THR 343 62, .568 35. .117 44. .670 1. .00 51. .24 1SG2678
ATOM 2678 CB THR 343 61, .119 34, .961 45. .025 1. .00 51. .24 1SG2679
ATOM 2679 OGl THR 343 60. .936 33. .811 45. .838 1. .00 51. .24 1SG2680
ATOM 2680 CG2 THR 343 60. .305 34. .830 43. .727 1. ,00 51. .24 1SG2681
ATOM 2681 C THR 343 63 .346 35. .091 45, .937 1. .00 51. .24 1SG2682
ATOM 2682 O THR 343 63. .628 34, .021 46, .473 1. .00 51, .24 1SG2683
ATOM 2683 N GLN 344 63. .753 36, .269 46. .435 1. .00 55. .93 1SG2684
ATOM 2684 CA GLN 344 64 .540 36, .247 47, .631 1. .00 55 .93 1SG2685
ATOM 2685 CB GLN 344 65 .739 37, .208 47, .575 1, .00 55 .93 1SG2686
ATOM 2686 CG GLN 344 66. .737 36, .844 46, .473 1. .00 55. .93 1SG2687
ATOM 2687 CD GLN 344 67, .877 37. .851 46. .506 1. .00 55, .93 1SG2688
ATOM 2688 OEl GLN 344 67 .873 38. .789 47, .302 1, .00 55 .93 1SG2689
ATOM 2689 NE2 GLN 344 68 .884 37. .652 45, .614 1, .00 55 .93 1SG2690
ATOM 2690 C GLN 344 63, .658 36. .675 48. .758 1. .00 55, .93 1SG2691
ATOM 2691 O GLN 344 63, .238 37. .827 48. .829 1. .00 55, .93 1SG2692
ATOM 2692 N PRO 345 63 .361 35 .763 49. .644 1. .00 61 .90 1SG2693
ATOM 2693 CA PRO 345 62 .547 36. .133 50. .765 1. .00 61. .90 1SG2694
ATOM 2694 CD PRO 345 63 .044 34. .415 49, .200 1. .00 61, .90 1SG2695
ATOM 2695 CB PRO 345 61, .956 34. .844 51, .322 1. .00 61, .90 1SG2696
ATOM 2696 CG PRO 345 61 .881 33. .936 50, .085 1, .00 61 .90 1SG2697
ATOM 2697 C PRO 345 63 .306 36. .948 51, .749 1, .00 61, .90 1SG2698
ATOM 2698 O PRO 345 64. .533 36. .982 51, .663 1. .00 61, .90 1SG2699
ATOM 2699 N LYS 346 62 .581 37, .626 52 .668 1. .00 65 .89 1SG2700
ATOM 2700 CA LYS 346 63 .200 38, .473 53, .646 1, .00 65, .89 1SG2701
ATOM 2701 CB LYS 346 62 .195 39. .343 54, .417 1, .00 65, .89 1SG2702
ATOM 2702 CG LYS 346 61. .482 40. .364 53. .528 1. .00 65, .89 1SG2703
ATOM 2703 CD LYS 346 60 .251 40, .994 54, .181 1. .00 65 .89 1SG2704
ATOM 2704 CE LYS 346 59 .540 42. .014 53, .289 1. .00 65, .89 1SG2705
ATOM 2705 NZ LYS 346 58. .365 42. .570 53, .996 1. .00 65, .89 1SG2706
ATOM 2706 C LYS 346 63. .903 37. .602 54. .628 1. .00 65, .89 1SG2707
ATOM 2707 0 LYS 346 63 .425 37, .323 55, .726 1, .00 65, .89 1SG2708
ATOM 2708 N ASN 347 65, .092 37, .167 54, .201 1. .00 69, .83 1SG2709
ATOM 2709 CA ASN 347 66, .054 36. .342 54, .849 1. .00 69, .83 1SG2710
ATOM 2710 CB ASN 347 65, .810 34. .823 54. .759 1. .00 69, .83 1SG2711
ATOM 2711 CG ASN 347 64, .429 34, .431 55. .242 1, .00 69, .83 1SG2712
ATOM 2712 ODl ASN 347 63, .643 33, .926 54. .442 1, .00 69, .83 1SG2713
ATOM 2713 ND2 ASN 347 64, .130 34. .643 56. .551 1. .00 69. .83 1SG2714
ATOM 2714 C ASN 347 67, .125 36. .499 53, .844 1. .00 69, .83 1SG2715
ATOM 2715 O ASN 347 67, .643 37, .584 53, .592 1. .00 69, .83 1SG2716
ATOM 2716 N SER 348 67, .464 35. .366 53, .229 1. .00 66. .51 1SG2717
ATOM 2717 CA SER 348 68, .337 35. .357 52. .107 1. .00 66. .51 1SG2718
ATOM 2718 CB SER 348 69, .817 35, .231 52. .502 1. .00 66, .51 1SG2719
ATOM 2719 OG SER 348 70, .630 35. .227 51. .339 1. .00 66. .51 1SG2720
ATOM 2720 C SER 348 67, .951 34. .102 51. .420 1. .00 66. .51 1SG2721 ATOM 2721 O SER 348 68..659 33..596 50,.552 1..00 66..51 1SG2722
ATOM 2722 N THR 349 66. .765 33 .587 51, .795 1. .00 60, .79 1SG2723
ATOM 2723 CA THR 349 66, .335 32, .337 51, .262 1. .00 60, .79 1SG2724
ATOM 2724 CB THR 349 65, .176 31 .724 51 .996 1, .00 60 .79 1SG2725
ATOM 2725 OGl THR 349 64, .893 30 .434 51, .474 1. .00 60, .79 1SG2726
ATOM 2726 CG2 THR 349 63, .954 32, .637 51, .867 1, .00 60, .79 1SG2727
ATOM 2727 C THR 349 65 .998 32 .514 49 .818 1 .00 60 .79 1SG2728
ATOM 2728 O THR 349 65, .747 33, .618 4 .342 1, .00 60, .79 1SG2729
ATOM 2729 N VAL 350 66, .042 31, .378 49, .102 1, .00 55 .72 1SG2730
ATOM 2730 CA VAL 350 65, .901 31 .181 47 .688 1, .00 55, .72 1SG2731
ATOM 2731 CB VAL 350 67, .021 30, .236 47, .317 1, .00 55, .72 1SG2732
ATOM 2732 CGI VAL 350 66 .794 29 .510 45 .991 1 .00 55 .72 1SG2733
ATOM 2733 CG2 VAL 350 68. .326 31. .047 47, .364 1, .00 55, .72 1SG2734
ATOM 2734 C VAL 350 64. .593 30. .497 47, .405 1, .00 55, .72 1SG2735
ATOM 2735 O VAL 350 64. .342 29 .402 47 .902 1 .00 55 .72 1SG2736
ATOM 2736 N GLU 351 63. .716 31. .118 46 .586 1, .00 51. .15 1SG2737
ATOM 2737 CA GLU 351 62 .495 30 .439 46 .236 1 .00 51 .15 1SG2738
ATOM 2738 CB GLU 351 61. .227 31. .156 46, .728 1, .00 51. .15 1SG2739
ATOM 2739 CG GLU 351 59. .963 30, .308 46 .588 1, .00 51 .15 1SG2740
ATOM 2740 CD GLU 351 60. .012 29 .214 47 .647 1 .00 51 .15 1SG2741
ATOM 2741 OEl GLU 351 61, .026 29 .158 48 .393 1 .00 51 .15 1SG2742
ATOM 2742 OE2 GLU 351 59. .036 28, .421 47, .723 1, .00 51 .15 1SG2743
ATOM 2743 C GLU 351 62. .446 30. .396 44 , .737 1, .00 51 .15 1SG2744
ATOM 2744 O GLU 351 62, .356 31. .435 44 .086 1 .00 51 .15 1SG2745
ATOM 2745 N THR 352 62, .512 29 .184 4 .143 1 .00 48 .94 1SG2746
ATOM 2746 CA THR 352 62. .609 29. .059 42, .711 1, .00 48. .94 1SG2747
ATOM 2747 CB THR 352 63. .098 27. .708 42 .261 1, .00 48 .94 1SG2748
ATOM 2748 OGl THR 352 63. .295 27. .704 40, .855 1, .00 48, .94 1SG2749
ATOM 2749 CG2 THR 352 62. .091 26 .621 42 .672 1 .00 48 .94 1SG2750
ATOM 2750 C THR 352 61. .307 29. .347 42, .029 1. .00 48 .94 1SG2751
ATOM 2751 O THR 352 60. .310 28. .656 42, .237 1, .00 48, .94 1SG2752
ATOM 2752 N ILE 353 61. .272 30, .437 41 .229 1 .00 46 .58 1SG2753
ATOM 2753 CA ILE 353 60. .095 30. .753 40, .473 1, .00 46, .58 1SG2754
ATOM 2754 CB ILE 353 59. .995 32. .203 40. .085 1 .00 46 .58 1SG2755
ATOM 2755 CG2 ILE 353 61. .151 32. .548 39, .142 1, .00 46 .58 1SG2756
ATOM 2756 CGI ILE 353 58. .605 32. .503 39, .498 1, .00 46, .58 1SG2757
ATOM 2757 CDl ILE 353 57. .472 32. .385 40, .516 1, .00 46 .58 1SG2758
ATOM 2758 C ILE 353 59. ,950 29. .904 39. .232 1, .00 46 .58 1SG2759
ATOM 2759 O ILE 353 58. .911 29. .278 39. .028 1, .00 46. .58 1SG2760
ATOM 2760 N VAL 354 60, .994 29. .840 38, .370 1, .00 41. .96 1SG2761
ATOM 2761 CA VAL 354 60. .869 29. .113 37, .128 1. .00 41. .96 1SG2762
ATOM 2762 CB VAL 354 60. .026 29. .843 36, .118 1, .00 41. .96 1SG2763
ATOM 2763 CGI VAL 354 60. ,731 31. ,165 35, .768 1. .00 41. .96 1SG2764
ATOM 2764 CG2 VAL 354 59. .770 28. .930 34. .905 1. .00 41. .96 1SG2765
ATOM 2765 C VAL 354 62. ,228 28. .916 36. .513 1. .00 41. .96 1SG2766
ATOM 2766 O VAL 354 63. ,191 29. .598 36. .859 1, .00 41. .96 1SG2767
ATOM 2767 N SER 355 62. ,335 27. ,959 35. ,565 1. .00 36. .43 1SG2768
ATOM 2768 CA SER 355 63. .581 27. ,701 34. .896 1, .00 36. .43 1SG2769
ATOM 2769 CB SER 355 64. .065 26. .249 35. .048 1. .00 36. .43 1SG2770
ATOM 2770 OG SER 355 63. .153 25. .359 34. .421 1. .00 36. .43 1SG2771
ATOM 2771 C SER 355 63. .371 27. 924 33. .430 1. .00 36. .43 1SG2772
ATOM 2772 O SER 355 62. ,382 27. .467 32. ,859 1. ,00 36. .43 1SG2773
ATOM 2773 N MET 356 64. ,311 28. ,635 32. ,774 1. .00 33. .27 1SG2774
ATOM 2774 CA MET 356 64. ,171 28. ,887 31. ,368 1. .00 33. .27 1SG2775
ATOM 2775 CB MET 356 64. .089 30. .380 30. .999 1. .00 33. .27 1SG2776
ATOM 2776 CG MET 356 62. 747 31. 035 31. 333 1. .00 33. .27 1SG2777
ATOM 2777 SD MET 356 62. .413 31. .270 33. .103 1. .00 33. .27 1SG2778 ATOM 2778 CE MET 356 60.743 31.933 32..837 1.00 33.27 1SG2779
ATOM 2779 C MET 356 65. 355 28. 326 30. .655 1. 00 33. 27 1SG2780
ATOM 2780 O MET 356 66. ,472 28. ,331 31. ,172 1. ,00 33. ,27 1SG2781
ATOM 2781 N ASP 357 65. ,119 27. ,802 29. .434 1. .00 30. ,16 1SG2782
ATOM 2782 CA ASP 357 66. 185 27. ,275 28. ,635 1. .00 30. ,16 1SG2783
ATOM 2783 CB ASP 357 65. 926 25. ,868 28. ,068 1. 00 30. .16 1SG2784
ATOM 2784 CG ASP 357 66. .067 24. .860 29. .198 1. .00 30. .16 1SG2785
ATOM 2785 ODl ASP 357 66. .546 25. ,262 30. .291 1. .00 30. .16 1SG2786
ATOM 2786 OD2 ASP 357 65. .689 23. ,676 28. .987 1. .00 30. ,16 1SG2787
ATOM 2787 C ASP 357 66. .352 28. ,191 27. .470 1. .00 30. ,16 1SG2788
ATOM 2788 O ASP 357 65. ,439 28. .381 26. .668 1. .00 30. .16 1SG2789
ATOM 2789 N PHE 358 67. ,549 28. .790 27. .367 1. .00 30. .71 1SG2790
ATOM 2790 CA PHE 358 67. ,887 29. .701 26. .317 1. .00 30. .71 1SG2791
ATOM 2791 CB PHE 358 68. .456 31. .028 26, .849 1, .00 30. .71 1SG2792
ATOM 2792 CG PHE 358 69. .700 31. .325 26, .077 1. .00 30. .71 1SG2793
ATOM 2793 CDl PHE 358 69. .671 31. .960 24. .857 1. .00 30. .71 1SG2794
ATOM 2794 CD2 PHE 358 70. .918 30. .939 26. .592 1. .00 30. .71 1SG2795
ATOM 2795 CE1 PHE 358 70. .842 32, .210 24 .176 1. .00 30. .71 1SG2796
ATOM 2796 CE2 PHE 358 72. .089 31, .186 25. .917 1. .00 30. .71 1SG2797
ATOM 2797 CZ PHE 358 72. .052 31. .826 24. .703 1. .00 30. .71 1SG2798
ATOM 2798 C PHE 358 68. .934 29. .091 25. .442 1. .00 30. .71 1SG2799
ATOM 2799 O PHE 358 69, .821 28. .381 25 .912 1. .00 30. .71 1SG2800
ATOM 2800 N VAL 359 68. .830 29. .358 24. .125 1. .00 32, .71 1SG2801
ATOM 2801 CA VAL 359 69. .798 28. .922 23, .159 1. .00 32. .71 1SG2802
ATOM 2802 CB VAL 359 69. .449 27. .618 22, .498 1. .00 32. .71 1SG2803
ATOM 2803 CGI VAL 359 68. .143 27 .802 21 .707 1. .00 32. .71 1SG2804
ATOM 2804 CG2 VAL 359 70. .637 27. .176 21 .626 1. .00 32. .71 1SG2805
ATOM 2805 C VAL 359 69. .804 29, .974 22 .094 1. .00 32. .71 1SG2806
ATOM 2806 O VAL 359 68. .813 30, .679 21, .912 1, .00 32. .71 1SG2807
ATOM 2807 N ALA 360 70. .928 30 .123 21 .364 1, .00 33. .85 1SG2808
ATOM 2808 CA ALA 360 70, .989 31, .148 20 .359 1, .00 33. .85 1SG2809
ATOM 2809 CB ALA 360 71. .255 32, .551 20 .932 1, .00 33, .85 1SG2810
ATOM 2810 C ALA 360 72 .121 30 .825 19 .440 1 .00 33, .85 1SG2811
ATOM 2811 O ALA 360 72. .758 29 .782 19 .571 1, .00 33, .85 1SG2812
ATOM 2812 N SER 361 72. .364 31 .710 18 .451 1, .00 37, .18 1SG2813
ATOM 2813 CA SER 361 73. .449 31. .564 17 .525 1, .00 37. .18 1SG2814
ATOM 2814 CB SER 361 73 .002 31 .490 16 .055 1 .00 37 .18 1SG2815
ATOM 2815 OG SER 361 74. .131 31 .340 15 .208 1 .00 37, .18 1SG2816
ATOM 2816 C SER 361 74, .277 32 .798 17 .693 1 .00 37, .18 1SG2817
ATOM 2817 O SER 361 73, .790 33 .815 18 .184 1, .00 37. .18 1SG2818
ATOM 2818 N THR 362 75 .568 32 .737 17 .318 1 .00 37. .92 1SG2819
ATOM 2819 CA THR 362 76 .434 33 .851 17 .577 1 .00 37, .92 1SG2820
ATOM 2820 CB THR 362 77, .157 33 .614 18 .871 1 .00 37, .92 1SG2821
ATOM 2821 OGl THR 362 76, .221 33 .493 19 .928 1, .00 37. .92 1SG2822
ATOM 2822 CG2 THR 362 78 .184 34 .719 19 .148 1 .00 37. .92 1SG2823
ATOM 2823 C THR 362 77, .501 33 .881 16 .532 1 .00 37. .92 1SG2824
ATOM 2824 O THR 362 77, .811 32 .866 15 .914 1, .00 37, .92 1SG2825
ATOM 2825 N SER 363 78 .117 35 .059 16 .318 1 .00 38 .24 1SG2826
ATOM 2826 CA SER 363 79 .214 35 .077 15 .403 1 .00 38, .24 1SG2827
ATOM 2827 CB SER 363 79 .088 36 .111 14 .269 1 .00 38, .24 1SG2828
ATOM 2828 OG SER 363 79, .163 37 .429 14 .787 1 .00 38, .24 1SG2829
ATOM 2829 C SER 363 80 .412 35 .423 16 .219 1 .00 38, .24 1SG2830
ATOM 2830 O SER 363 80 .355 36 .321 17 .058 1 .00 38, .24 1SG2831
ATOM 2831 N VAL 364 81, .529 34 .692 16 .028 1 .00 38, .46 1SG2832
ATOM 2832 CA VAL 364 82, .672 35, .058 16 .807 1, .00 38. .46 1SG2833
ATOM 2833 CB VAL 364 83 .226 33 .973 17 .683 1 .00 38. .46 1SG2834
ATOM 2834 CGI VAL 364 82 .160 33 .625 18 .725 1 .00 38, .46 1SG2835 ATOM 2835 CG2 VAL 364 83..660 32..781 16..824 1..00 38..46 1SG2836
ATOM 2836 C VAL 364 83, .753 35, .523 15. .894 1. .00 38, .46 1SG2837
ATOM 2837 O VAL 364 84 .231 34, .783 15. .035 1. .00 38 .46 1SG2838
ATOM 2838 N GLY 365 84, .154 36, .799 16. .061 1. .00 37, .82 1SG2839
ATOM 2839 CA GLY 365 85. .203 37, .356 15. .261 1. .00 37 .82 1SG2840
ATOM 2840 C GLY 365 86. .502 37, .028 15. .922 1, .00 37, .82 1SG2841
ATOM 2841 O GLY 365 86, .567 36, .904 17. .143 1. .00 37. .82 1SG2842
ATOM 2842 N LEU 366 87 .583 36 .901 15. .126 1. .00 40. .31 1SG2843
ATOM 2843 CA LEU 366 88, .861 36, .592 15, .701 1. .00 40 .31 1SG2844
ATOM 2844 CB LEU 366 89, .339 35. .166 15. .375 1. .00 40. .31 1SG2845
ATOM 2845 CG LEU 366 88, .430 34, .071 15. .963 1. .00 40. .31 1SG2846
ATOM 2846 CD2 LEU 366 89 .065 32 .679 15. .816 1. .00 40. .31 1SG2847
ATOM 2847 CDl LEU 366 87 .013 34 .141 15 .370 1 .00 40 .31 1SG2848
ATOM 2848 C LEU 366 89, .884 37, .543 15. .155 1. .00 40. .31 1SG2849
ATOM 2849 O LEU 366 89, .952 37, .778 13. .948 1. .00 40. .31 1SG2850
ATOM 2850 N VAL 367 90 .715 38 .108 16 .056 1. .00 42. .12 1SG2851
ATOM 2851 CA VAL 367 91, .743 39, .042 15. .688 1. .00 42, .12 1SG2852
ATOM 2852 CB VAL 367 91. .389 40, .467 15. .995 1. .00 42 , .12 1SG2853
ATOM 2853 CGI VAL 367 90. .150 40 .854 15. .168 1. .00 42, .12 1SG2854
ATOM 2854 CG2 VAL 367 91, .196 40, .607 17, .514 1. .00 42. .12 1SG2855
ATOM 2855 C VAL 367 9 .942 38 .717 16 .518 1, .00 42, .12 1SG2856
ATOM 2856 O VAL 367 92, .874 37, .886 17, .422 1. .00 42, .12 1SG2857
ATOM 2857 N ILE 368 94. .094 39, .348 16. .212 1. .00 46. .08 1SG2858
ATOM 2858 CA ILE 368 95. .261 39, .022 16. .976 1. .00 46, .08 1SG2859
ATOM 2859 CB ILE 368 96. .229 38 .204 16. .169 1, .00 46 .08 1SG2860
ATOM 2860 CG2 ILE 368 96, .897 39 .118 15. .129 1, .00 46 .08 1SG2861
ATOM 2861 CGI ILE 368 97. .208 37, .461 17, .081 1. .00 46, .08 1SG2862
ATOM 2862 CDl ILE 368 98, .112 38 .378 17, .897 1. .00 46, .08 1SG2863
ATOM 2863 C ILE 368 95 .916 40 .290 17 .437 1. .00 46 .08 1SG2864
ATOM 2864 O ILE 368 96. .092 41, .237 16, .672 1. .00 46, .08 1SG2865
ATOM 2865 N LEU 369 96, .271 40, .338 18, .736 1. .00 50, .68 1SG2866
ATOM 2866 CA LEU 369 96, .970 41 .455 19, .295 1. .00 50, .68 1SG2867
ATOM 2867 CB LEU 369 96, .173 42, .155 20, .418 1. .00 50, .68 1SG2868
ATOM 2868 CG LEU 369 96. .754 43 .485 20, .955 1, .00 50, .68 1SG2869
ATOM 2869 CD2 LEU 369 98. .214 43, .366 21, .419 1. .00 50, .68 1SG2870
ATOM 2870 CDl LEU 369 95. .850 44, .058 22. .059 1. .00 50. .68 1SG2871
ATOM 2871 C LEU 369 98, .208 40 .863 19. .883 1. .00 50, .68 1SG2872
ATOM 2872 O LEU 369 98 .150 39 .868 20. .606 1, .00 50, .68 1SG2873
ATOM 2873 N GLY 370 99, .375 41, .452 19. .567 1. .00 53. .21 1SG2874
ATOM 2874 CA GLY 370 100. .590 40, .925 20. .102 1. ,00 53. .21 1SG2875
ATOM 2875 C GLY 370 100, .703 39 .497 19. .668 1. .00 53. .21 1SG2876
ATOM 2876 O GLY 370 100, .667 39 .169 18. .484 1. .00 53, .21 1SG2877
ATOM 2877 N GLN 371 100. .962 38, .644 20. .668 1. .00 57. .38 1SG2878
ATOM 2878 CA GLN 371 101. .129 37, .219 20. .685 1. .00 57. .38 1SG2879
ATOM 2879 CB GLN 371 101, .943 36 .852 21. .936 1. .00 57. .38 1SG2880
ATOM 2880 CG GLN 371 102. .253 35, .378 22. .170 1. .00 57. .38 1SG2881
ATOM 2881 CD GLN 371 103. .047 35, .335 23. .471 1. .00 57. .38 1SG2882
ATOM 2882 OEl GLN 371 104. .137 35, .893 23. .581 1. .00 57. .38 1SG2883
ATOM 2883 NE2 GLN 371 102. .465 34. .668 24. ,504 1. .00 57. .38 1SG2884
ATOM 2884 C GLN 371 99. .821 36. .463 20. .739 1. .00 57. .38 1SG2885
ATOM 2885 O GLN 371 99. .779 35 .276 20. .414 1. ,00 57. .38 1SG2886
ATOM 2886 N ARG 372 98. ,740 37. .099 21. .244 1. 00 57. 23 1SG2887
ATOM 2887 CA ARG 372 97. ,542 36. .366 21. ,585 1. ,00 57. 23 1SG2888
ATOM 2888 CB ARG 372 96. .940 36, .833 22. .919 1. ,00 57. .23 1SG2889
ATOM 2889 CG ARG 372 96. .644 38, .331 22. .945 1. .00 57. .23 1SG2890
ATOM 2890 CD ARG 372 96. .062 38. .811 24. .274 1. 00 57. 23 1SG2891
ATOM 2891 NE ARG 372 96. ,062 40. .299 24. ,249 1. 00 57. .23 1SG2892 ATOM 2892 CZ ARG 372 97..167 40..972 24..683 1..00 57..23 1SG2893
ATOM 2893 NHl ARG 372 98, .247 40. .278 25. .150 1. .00 57. .23 1SG2894
ATOM 2894 NH2 ARG 372 97, .197 42. .336 24. .646 1. .00 57, .23 1SG2895
ATOM 2895 C ARG 372 96, .441 36, .376 20. .568 1. .00 57, .23 1SG2896
ATOM 2896 O ARG 372 96, .378 37, .214 19. .674 1. .00 57. .23 1SG2897
ATOM 2897 N LEU 373 95, .533 35, .378 20. .708 1. .00 53. .53 1SG2898
ATOM 2898 CA LEU 373 94 .389 35 .194 19, .862 1. .00 53 .53 1SG2899
ATOM 2899 CB LEU 373 94, .144 33, .707 19, .537 1. .00 53. .53 1SG2900
ATOM 2900 CG LEU 373 92, .940 33, .421 18. .621 1. .00 53, .53 1SG2901
ATOM 2901 CD2 LEU 373 92, .572 31. .928 18. .638 1. .00 53, .53 1SG2902
ATOM 2902 CDl LEU 373 93, .171 33. .960 17. .199 1. .00 53, .53 1SG2903
ATOM 2903 C LEU 373 93 .213 35. .709 20, .636 1. .00 53 .53 1SG2904
ATOM 2904 O LEU 373 92 .887 35, .190 21, .703 1, .00 53, .53 1SG2905
ATOM 2905 N VAL 374 92, .540 36, .757 20. .115 1, .00 51, .95 1SG2906
ATOM 2906 CA VAL 374 91, .450 37, .357 20. .830 1. .00 51, .95 1SG2907
ATOM 2907 CB VAL 374 91, .686 38, .809 21. .127 1. .00 51, .95 1SG2908
ATOM 2908 CGI VAL 374 90 .474 39, .345 21. .882 1, .00 51 .95 1SG2909
ATOM 2909 CG2 VAL 374 92 .987 38. .965 21. .920 1, .00 51 .95 1SG2910
ATOM 2910 C VAL 374 90, .228 37, .289 19. .967 1, .00 51, .95 1SG2911
ATOM 2911 O VAL 374 90, .329 37, .216 18. .745 1. .00 51 .95 1SG2912
ATOM 2912 N CYS 375 89, .030 37. .288 20. .588 1, .00 48, .07 1SG2913
ATOM 2913 CA CYS 375 87 .831 37 .224 19, .802 1 .00 48 .07 1SG2914
ATOM 2914 CB CYS 375 87 .392 35 .780 19, .501 1, .00 48 .07 1SG2915
ATOM 2915 SG CYS 375 87, .112 34 .800 21. .003 1, .00 48 .07 1SG2916
ATOM 2916 C CYS 375 86, .716 37. .908 20. .528 1, .00 48, .07 1SG2917
ATOM 2917 O CYS 375 86, .864 38, .324 21. .675 1. .00 48, .07 1SG2918
ATOM 2918 N SER 376 85 .559 38 .067 19, .848 1 .00 46 .80 1SG2919
ATOM 2919 CA SER 376 84 .426 38 .689 20, .468 1, .00 46 .80 1SG2920
ATOM 2920 CB SER 376 84, .245 40, .170 20, .092 1, .00 46 .80 1SG2921
ATOM 2921 OG SER 376 83, .100 40, .702 20. .743 1, .00 46, .80 1SG2922
ATOM 2922 C SER 376 83, .195 37, .959 20. .026 1. .00 46, .80 1SG2923
ATOM 2923 O SER 376 83 .133 37 .428 18, .918 1. .00 46 .80 1SG2924
ATOM 2924 N LEU 377 82 .181 37, .921 20. .912 1, .00 48, .75 1SG2925
ATOM 2925 CA LEU 377 80, .920 37, .270 20. .674 1, .00 48. .75 1SG2926
ATOM 2926 CB LEU 377 80, .334 36, .567 21. .913 1, .00 48. .75 1SG2927
ATOM 2927 CG LEU 377 80. .814 35, .140 22. .183 1. .00 48. .75 1SG2928
ATOM 2928 CD2 LEU 377 80 .415 34 .243 21. .009 1. .00 48 .75 1SG2929
ATOM 2929 CDl LEU 377 80. .230 34, .597 23. .497 1. .00 48. .75 1SG2930
ATOM 2930 C LEU 377 79, .878 38, .293 20. .368 1. .00 48, .75 1SG2931
ATOM 2931 O LEU 377 79, .837 39, .358 20. .983 1. .00 48. .75 1SG2932
ATOM 2932 N SER 378 78, .993 37, .968 19. .402 1. .00 46. .08 1SG2933
ATOM 2933 CA SER 378 77, .860 38 .799 19, .107 1. .00 46, .08 1SG2934
ATOM 2934 CB SER 378 77, .973 39, .597 17. .799 1. .00 46, .08 1SG2935
ATOM 2935 OG SER 378 77, .908 38, .717 16. .688 1. .00 46. .08 1SG2936
ATOM 2936 C SER 378 76, .707 37. .855 18. .952 1. .00 46. .08 1SG2937
ATOM 2937 O SER 378 76. .794 36. .871 18. ,222 1. .00 46. .08 1SG2938
ATOM 2938 N LEU 379 75. .579 38. .137 19. .627 1. .00 45. .61 1SG2939
ATOM 2939 CA LEU 379 74, .491 37, .196 19. .627 1. .00 45. .61 1SG2940
ATOM 2940 CB LEU 379 73, .860 37, .025 21. .022 1. .00 45. .61 1SG2941
ATOM 2941 CG LEU 379 74. .860 36, .682 22. .147 1. .00 45. .61 1SG2942
ATOM 2942 CD2 LEU 379 75. .798 35. .531 21. .764 1. .00 45. .61 1SG2943
ATOM 2943 CDl LEU 379 74, .131 36. .439 23. .476 1. .00 45. .61 1SG2944
ATOM 2944 C LEU 379 73. .388 37. .675 18. ,729 1. .00 45. .61 1SG2945
ATOM 2945 O LEU 379 73. .339 38. .843 18. ,349 1. .00 45. .61 1SG2946
ATOM 2946 N ASN 380 72. .466 36. .755 18. ,363 1. .00 45. .45 1SG2947
ATOM 2947 CA ASN 380 71. .312 37. ,098 17. 577 1. ,00 45. .45 1SG2948
ATOM 2948 CB ASN 380 71. .168 36. .346 16. .232 1. .00 45. .45 1SG2949 ATOM 2949 CG ASN 380 71..083 34..843 16.,439 1.00 45..45 1SG2950
ATOM 2950 ODl ASN 380 72. .098 34. .160 16. ,336 1. 00 45. .45 1SG2951
ATOM 2951 ND2 ASN 380 69. .863 34. .307 16. .709 1. 00 45. .45 1SG2952
ATOM 2952 C ASN 380 70. .104 36. .863 18. .446 1. .00 45. .45 1SG2953
ATOM 2953 O ASN 380 70. .197 36. .937 19. .669 1. ,00 45. .45 1SG2954
ATOM 2954 N ARG 381 68. .925 36. .611 17. .841 1. ,00 44. .44 1SG2955
ATOM 2955 CA ARG 381 67. .702 36. .432 18. .581 1. ,00 44. .44 1SG2956
ATOM 2956 CB ARG 381 66. .504 36. .063 17. .685 1. ,00 44 , .44 1SG2957
ATOM 2957 CG ARG 381 66. .081 37. .188 16. .735 1. .00 44, .44 1SG2958
ATOM 2958 CD ARG 381 64. .925 36. .809 15. .806 1. .00 44, .44 1SG2959
ATOM 2959 NE ARG 381 64. .442 38. .062 15. .156 1. ,00 44, .44 1SG2960
ATOM 2960 CZ ARG 381 64. .991 38. .516 13. .990 1. .00 44, .44 1SG2961
ATOM 2961 NHl ARG 381 65. .977 37. .805 13. .368 1. .00 44. .44 1SG2962
ATOM 2962 NH2 ARG 381 64. .549 39, .683 13. .439 1. .00 44. .44 1SG2963
ATOM 2963 C ARG 381 67. .886 35, .333 19. .586 1. .00 44, .44 1SG2964
ATOM 2964 O ARG 381 68. .673 34 , .412 19. .377 1. .00 44, .44 1SG2965
ATOM 2965 N PHE 382 67. .167 35, .418 20. .730 1. .00 45, .27 1SG2966
ATOM 2966 CA PHE 382 67, .329 34, .422 21. .756 1. .00 45, .27 1SG2967
ATOM 2967 CB PHE 382 67. .186 34, .921 23. .203 1. .00 45, .27 1SG2968
ATOM 2968 CG PHE 382 67. .682 36, .312 23 , .375 1. .00 45, .27 1SG2969
ATOM 2969 CDl PHE 382 68, .983 36 , .608 23 , .703 1. .00 45. .27 1SG2970
ATOM 2970 CD2 PHE 382 66 , .782 37, .339 23. .212 1. .00 45, .27 1SG2971
ATOM 2971 CE1 PHE 382 69, .374 37, .919 23. .860 1. .00 45 .27 1SG2972
ATOM 2972 CE2 PHE 382 67, .167 38, .647 23, .367 1. .00 45 .27 1SG2973
ATOM 2973 CZ PHE 382 68, .466 38, .940 23. .695 1. .00 45 .27 1SG2974
ATOM 2974 C PHE 382 66, .094 33, .576 21. .684 1. .00 45 .27 1SG2975
ATOM 2975 O PHE 382 65, .008 34 , .096 21, .433 1. .00 45 .27 1SG2976
ATOM 2976 N ARG 383 66, .208 32, .253 21. .922 1. .00 44 .64 1SG2977
ATOM 2977 CA ARG 383 64, .993 31, .489 21. .939 1. .00 44 .64 1SG2978
ATOM 2978 CB ARG 383 64, .974 30, .238 21. .053 1. .00 44 .64 1SG2979
ATOM 2979 CG ARG 383 63, .552 29, .853 20. .650 1. .00 44 .64 1SG2980
ATOM 2980 CD ARG 383 63, .089 30, .656 19. .439 1. .00 44 .64 1SG2981
ATOM 2981 NE ARG 383 64, .002 30, .272 18, .326 1. .00 44 .64 1SG2982
ATOM 2982 CZ ARG 383 63, .466 29, .717 17, .207 1. .00 44 .64 1SG2983
ATOM 2983 NHl ARG 383 62. .117 29, .539 17, .133 1. .00 44 .64 1SG2984
ATOM 2984 NH2 ARG 383 64. .267 29, .336 16, .163 1. .00 44 .64 1SG2985
ATOM 2985 C ARG 383 64, .810 30, .990 23, .336 1. .00 44 .64 1SG2986
ATOM 2986 O ARG 383 65, .739 30, .462 23 , .946 1. .00 44 .64 1SG2987
ATOM 2987 N LEU 384 63 , .587 31, .145 23, .876 1. .00 42 .97 1SG2988
ATOM 2988 CA LEU 384 63. .306 30, .729 25, .217 1. .00 42, .97 1SG2989
ATOM 2989 CB LEU 384 62, .436 31, .727 25, .994 1. .00 42. .97 1SG2990
ATOM 2990 CG LEU 384 63 , .105 33, .083 26, .250 1. .00 42, .97 1SG2991
ATOM 2991 CD2 LEU 384 62, .205 33, .983 27, .112 1. .00 42, .97 1SG2992
ATOM 2992 CDl LEU 384 63. .525 33, .764 24, .941 1. .00 42, .97 1SG2993
ATOM 2993 C LEU 384 62, .508 29, .469 25, .160 1. .00 42. .97 1SG2994
ATOM 2994 O LEU 384 61, .816 29, .190 24, .182 1. .00 42, .97 1SG2995
ATOM 2995 N ALA 385 62. .621 28, .662 26, .229 1. .00 41, .04 1SG2996
ATOM 2996 CA ALA 385 61, .857 27, .460 26, .373 1. .00 41, .04 1SG2997
ATOM 2997 CB ALA 385 62. .630 26. .182 26, .005 1. .00 41, .04 1SG2998
ATOM 2998 C ALA 385 61. .557 27, .387 27, .833 1. .00 41, .04 1SG2999
ATOM 2999 O ALA 385 62. .361 27, .838 28, .647 1. .00 41, .04 1SG3000
ATOM 3000 N LEU 386 60. .387 26, .832 28, .211 1. .00 40, .71 1SG3001
ATOM 3001 CA LEU 386 60. .061 26, .783 29, .609 1. .00 40, .71 1SG3002
ATOM 3002 CB LEU 386 58. .613 27, .223 29. .900 1. .00 40, .71 1SG3003
ATOM 3003 CG LEU 386 58. .286 27, .332 31, .401 1. .00 40, .71 1SG3004
ATOM 3004 CD2 LEU 386 56. .778 27. .507 31, .641 1. .00 40, .71 1SG3005
ATOM 3005 CDl LEU 386 59. .118 28. .442 32, .064 1. .00 40. .71 1SG3006 ATOM 3006 C LEU 386 60..210 25..363 30..074 1.,00 40..71 1SG3007
ATOM 3007 O LEU 386 59. .475 24. .473 29. .646 1. ,00 40. .71 1SG3008
ATOM 3008 N PRO 387 61. .231 25. .122 30. .857 1. .00 41. .29 1SG3009
ATOM 3009 CA PRO 387 61. .431 23. .813 31. .430 1. .00 41. .29 1SG3010
ATOM 3010 CD PRO 387 62. .493 25. .788 30. .589 1. .00 41. .29 1SG3011
ATOM 3011 CB PRO 387 62. .892 23. .758 31. .861 1. .00 41. .29 1SG3012
ATOM 3012 CG PRO 387 63. .582 24. .757 30. .920 1. .00 41. .29 1SG3013
ATOM 3013 C PRO 387 60. .491 23, .416 32. .527 1. .00 41. .29 1SG3014
ATOM 3014 O PRO 387 60. .029 22 , .276 32. .527 1. .00 41. .29 1SG3015
ATOM 3015 N GLU 388 60. .206 24 , .329 33. .479 1. .00 45. .60 1SG3016
ATOM 3016 CA GLU 388 59. .329 24. .001 34, .568 1. ,00 45. .60 1SG3017
ATOM 3017 CB GLU 388 59, .920 22 .996 35 .573 1. .00 45. .60 1SG3018
ATOM 3018 CG GLU 388 61, .154 23 .509 36 .319 1. .00 45. .60 1SG3019
ATOM 3019 CD GLU 388 61, .606 22 .406 37 .266 1. .00 45. .60 1SG3020
ATOM 3020 OEl GLU 388 60, .917 21, .351 37 .307 1. .00 45, .60 1SG3021
ATOM 3021 OE2 GLU 388 62, .639 22 .599 37 .961 1. .00 45, .60 1SG3022
ATOM 3022 C GLU 388 59, .069 25 .267 35 .316 1, .00 45, .60 1SG3023
ATOM 3023 O GLU 388 59, .920 26 .152 35 .366 1. .00 45, .60 1SG3024
ATOM 3024 N SER 389 57, .868 25 .396 35 .917 1, .00 50 .84 1SG3025
ATOM 3025 CA SER 389 57, .602 26 .609 36 .624 1. .00 50 .84 1SG3026
ATOM 3026 CB SER 389 56, .725 27 .596 35 .832 1. .00 50 .84 1SG3027
ATOM 3027 OG SER 389 56, .501 28 .775 36 .591 1. .00 50 .84 1SG3028
ATOM 3028 C SER 389 56, .868 26 .276 37 .877 1. .00 50 .84 1SG3029
ATOM 3029 O SER 389 55, .943 25 .466 37 .880 1, .00 50, .84 1SG3030
ATOM 3030 N ASN 390 57, .301 26 .887 38 .992 1. .00 56 .50 1SG3031
ATOM 3031 CA ASN 390 56, .649 26 .700 40 .248 1. .00 56 .50 1SG3032
ATOM 3032 CB ASN 390 57, .487 27, .222 41 .421 1. .00 56 .50 1SG3033
ATOM 3033 CG ASN 390 57, .016 26 .449 42 .632 1. .00 56 .50 1SG3034
ATOM 3034 ODl ASN 390 56, .221 25, .525 42 .471 1. .00 56 .50 1SG3035
ATOM 3035 ND2 ASN 390 57, .511 26, .812 43 .845 1. .00 56, .50 1SG3036
ATOM 3036 C ASN 390 55, .367 27, .482 40 .212 1. .00 56 .50 1SG3037
ATOM 3037 O ASN 390 54, .363 27, .107 40 .816 1. .00 56 .50 1SG3038
ATOM 3038 N ARG 391 55, .417 28, .627 39 .502 1. .00 61, .79 1SG3039
ATOM 3039 CA ARG 391 54 , .391 29, .622 39 .346 1. .00 61 .79 1SG3040
ATOM 3040 CB ARG 391 54, .930 30, .875 38 .630 1 , .00 61, .79 1SG3041
ATOM 3041 CG ARG 391 53, .873 31, .912 38 .252 1. .00 61, .79 1SG3042
ATOM 3042 CD ARG 391 53, .528 31, .900 36 .760 1. .00 61, .79 1SG3043
ATOM 3043 NE ARG 391 52, .323 31, .045 36 .578 1. .00 61, .79 1SG3044
ATOM 3044 CZ ARG 391 51, .449 31, .314 35, .565 1. .00 61, .79 1SG3045
ATOM 3045 NHl ARG 391 51. .691 32. .352 34, .711 1. .00 61, .79 1SG3046
ATOM 3046 NH2 ARG 391 50. .328 30. .551 35, .411 1. .00 61, .79 1SG3047
ATOM 3047 C ARG 391 53. .199 29, .134 38, .585 1. .00 61, .79 1SG3048
ATOM 3048 O ARG 391 52. .108 29, .636 38, .827 1. .00 61, .79 1SG3049
ATOM 3049 N SER 392 53. .390 28. .233 37, .600 1. .00 59, .29 1SG3050
ATOM 3050 CA SER 392 52. .372 27, .630 36. .769 1. .00 59. .29 1SG3051
ATOM 3051 CB SER 392 50. .913 28, .101 36. .941 1. .00 59. .29 1SG3052
ATOM 3052 OG SER 392 50. .442 27. .757 38, .236 1. .00 59. .29 1SG3053
ATOM 3053 C SER 392 52. .765 27. .938 35, .368 1. .00 59. .29 1SG3054
ATOM 3054 O SER 392 53. .750 28. .637 35, .142 1. .00 59. .29 1SG3055
ATOM 3055 N ASN 393 52. .002 27. .425 34, .385 1. .00 56. .59 1ΞG3056
ATOM 3056 CA ASN 393 52. .376 27. .659 33, .021 1. .00 56. .59 1SG3057
ATOM 3057 CB ASN 393 51. .676 26. .733 32, .010 1. .00 56. .59 1SG3058
ATOM 3058 CG ASN 393 50. ,185 27. .031 32, .038 1. .00 56. .59 1SG3059
ATOM 3059 ODl ASN 393 49. ,673 27. .780 31. .207 1. .00 56. .59 1SG3060
ATOM 3060 ND2 ASN 393 49. ,463 26. .427 33. .019 1. .00 56. .59 1SG3061
ATOM 3061 C ASN 393 52. ,036 29. .068 32. .656 1. .00 56. .59 1SG3062
ATOM 3062 O ASN 393 50. .980 29. .586 33. .015 1. .00 56. .59 1SG3063 ATOM 3063 N ILE 394 52,.961 29.725 31,.931 1,.00 52,.10 1SG3064
ATOM 3064 CA ILE 394 52, .784 31, .071 31. .475 1, .00 52, .10 1SG3065
ATOM 3065 CB ILE 394 53. .448 32 .090 32. .355 1, .00 52 .10 1SG3066
ATOM 3066 CG2 ILE 394 54. .964 31 .838 32. .308 1, .00 52 .10 1SG3067
ATOM 3067 CGI ILE 394 53. .035 33 .511 31. .940 1, .00 52, .10 1SG3068
ATOM 3068 CDl ILE 394 51 .556 33 .810 32. .181 1 .00 52 .10 1SG3069
ATOM 3069 C ILE 394 53. .414 31 .175 30. .124 1 .00 52 .10 1SG3070
ATOM 3070 O ILE 394 54. .150 30, .285 29. .697 1, .00 52 .10 1SG3071
ATOM 3071 N GLU 395 53 .121 32 .268 29, .394 1, .00 47 .57 1SG3072
ATOM 3072 CA GLU 395 53, .724 32 .402 28, .101 1 .00 47 .57 1SG3073
ATOM 3073 CB GLU 395 53, .144 33, .553 27, .259 1, .00 47, .57 1SG3074
ATOM 3074 CG GLU 395 51, .699 33 .320 26, .812 1, .00 47 .57 1SG3075
ATOM 3075 CD GLU 395 50, .789 33 .566 28, .006 1, .00 47 .57 1SG3076
ATOM 3076 OEl GLU 395 51, .210 34, .320 28, .924 1, .00 47, .57 1SG3077
ATOM 3077 OE2 GLU 395 49 .661 33 .005 28. .017 1, .00 47. .57 1SG3078
ATOM 3078 C GLU 395 55 .180 32 .675 28, .321 1 .00 47 .57 1SG3079
ATOM 3079 O GLU 395 55, .565 33 .636 28, .984 1, .00 47 .57 1SG3080
ATOM 3080 N VAL 396 56, .030 31, .817 27, .733 1, .00 47, .78 1SG3081
ATOM 3081 CA VAL 396 57, .460 31 .897 27, .850 1 .00 47 .78 1SG3082
ATOM 3082 CB VAL 396 58, .180 30 .751 27, .194 1, .00 47 .78 1SG3083
ATOM 3083 CGI VAL 396 57, .752 29. .450 27, .887 1. .00 47 .78 1SG3084
ATOM 3084 CG2 VAL 396 57, .910 30 .773 25, .682 1, .00 47 .78 1SG3085
ATOM 3085 C VAL 396 57, .927 33, .158 27, .194 1, .00 47 .78 1SG3086
ATOM 3086 O VAL 396 59, .012 33, .655 27, .492 1. .00 47 .78 1SG3087
ATOM 3087 N LEU 397 57, .118 33 .674 26, .251 1, .00 46 .36 1SG3088
ATOM 3088 CA LEU 397 57, .401 34, .832 25, .447 1, .00 46 .36 1SG3089
ATOM 3089 CB LEU 397 56, .319 35, .104 24 , .387 1. .00 46, .36 1SG3090
ATOM 3090 CG LEU 397 56, .215 34 .011 23, .308 1, .00 46 .36 1SG3091
ATOM 3091 CD2 LEU 397 55, .328 34, .467 22, .138 1, .00 46 .36 1SG3092
ATOM 3092 CDl LEU 397 55, ,771 32, .667 23, .908 1. .00 46, .36 1SG3093
ATOM 3093 C LEU 397 57, .521 36 .080 26, .278 1, .00 46 .36 1SG3094
ATOM 3094 O LEU 397 58, .218 37, .013 25, .886 1, .00 46, .36 1SG3095
ATOM 3095 N ARG 398 56, .830 36, .150 27. .430 1. .00 44, .35 1SG3096
ATOM 3096 CA ARG 398 56, .786 37 .344 28, .237 1. .00 44 .35 1SG3097
ATOM 3097 CB ARG 398 55, .946 37, .155 29, .511 1. .00 44, .35 1SG3098
ATOM 3098 CG ARG 398 54, .465 36, .910 29, .225 1. .00 44 , .35 1SG3099
ATOM 3099 CD ARG 398 53, .692 38 .190 28, .901 1. .00 44 .35 1SG3100
ATOM 3100 NE ARG 398 54, .227 38. .722 27, .617 1. .00 44, .35 1SG3101
ATOM 3101 CZ ARG 398 53. .584 39, .748 26. .987 1. .00 44 , .35 1SG3102
ATOM 3102 NHl ARG 398 52. .453 40 .283 27, .534 1. .00 44. .35 1SG3103
ATOM 3103 NH2 ARG 398 54. .070 40. .238 25. .809 1. .00 44. .35 1SG3104
ATOM 3104 C ARG 398 58. .164 37. .759 28. .669 1. .00 44. .35 1SG3105
ATOM 3105 O ARG 398 58. .441 38. .950 28. .806 1. .00 44. .35 1SG3106
ATOM 3106 N PHE 399 59. .043 36. .776 28. .924 1. .00 42. .26 1SG3107
ATOM 3107 CA PHE 399 60. .398 36. .917 29. .390 1. .00 42. .26 1SG3108
ATOM 3108 CB PHE 399 60. .998 35, .590 29. .884 1. .00 42 , .26 1SG3109
ATOM 3109 CG PHE 399 60. .321 35, .279 31. .175 1. ,00 42. .26 1SG3110
ATOM 3110 CDl PHE 399 59. .020 34. .831 31. .194 1. ,00 42. .26 1SG3111
ATOM 3111 CD2 PHE 399 60. .990 35, .427 32. .368 1. , 00 42. .26 1SG3112
ATOM 3112 CE1 PHE 399 58. .395 34. .545 32. ,385 1. ,00 42. .26 1SG3113
ATOM 3113 CE2 PHE 399 60. .370 35. .141 33. ,561 1. ,00 42. ,26 1SG3114
ATOM 3114 CZ PHE 399 59. .069 34. .699 33. .572 1. .00 42. .26 1SG3115
ATOM 3115 C PHE 399 61. .310 37. .489 28. .341 1. ,00 42. .26 1SG3116
ATOM 3116 O PHE 399 62. .409 37. ,935 28. .662 1. ,00 42. ,26 1SG3117
ATOM 3117 N GLU 400 60. .921 37. .442 27. .054 1. ,00 39. .05 1SG3118
ATOM 3118 CA GLU 400 61. ,795 37. ,844 25. ,983 1. ,00 39. .05 1SG3119
ATOM 3119 CB GLU 400 61. ,079 37. ,892 24. 621 1. 00 39. .05 1SG3120 ATOM 3120 CG GLU 400 60..865 36..526 23..967 1,.00 39..05 1SG3121
ATOM 3121 CD GLU 400 62, .033 36, .293 23. .018 1, .00 39, .05 1SG3122
ATOM 3122 OEl GLU 400 62, .926 37, .179 22. .952 1, .00 39, .05 1SG3123
ATOM 3123 OE2 GLU 400 62, .044 35, .230 22. .340 1, .00 39, .05 1SG3124
ATOM 3124 C GLU 400 62. .363 39. .217 26. .206 1, .00 39, .05 1SG3125
ATOM 3125 O GLU 400 63, .561 39, .414 26. .007 1 .00 39 .05 1SG3126
ATOM 3126 N ASN 401 61, .548 40, .207 26, .619 1, .00 37, .23 1SG3127
ATOM 3127 CA ASN 401 62, .065 41, .541 26, .775 1, .00 37 .23 1SG3128
ATOM 3128 CB ASN 401 61, .002 42, .557 27. .231 1, .00 37, .23 1SG3129
ATOM 3129 CG ASN 401 60, .015 42, .775 26. .094 1, .00 37, .23 1SG3130
ATOM 3130 ODl ASN 401 60, .400 43, .036 24. .956 1, .00 37. .23 1SG3131
ATOM 3131 ND2 ASN 401 58 .697 42 .662 26. .412 1 .00 37 .23 1SG3132
ATOM 3132 C ASN 401 63 .133 41, .541 27. .820 1, .00 37 .23 1SG3133
ATOM 3133 O ASN 401 64 .194 42, .134 27, .632 1, .00 37. .23 1SG3134
ATOM 3134 N ILE 402 62 .877 40, .874 28, .959 1, .00 36 .96 1SG3135
ATOM 3135 CA ILE 402 63, .844 40, .848 30, .013 1, .00 36, .96 1SG3136
ATOM 3136 CB ILE 402 63, .344 40, .192 31, .265 1. .00 36, .96 1SG3137
ATOM 3137 CG2 ILE 402 64, .541 39, .849 32 , ,165 1, .00 36, .96 1SG3138
ATOM 3138 CGI ILE 402 62 .297 41 .099 31, .930 1 .00 36 .96 1SG3139
ATOM 3139 CDl ILE 402 61 .699 40, .501 33, .196 1 .00 36 .96 1SG3140
ATOM 3140 C ILE 402 65 .073 40, .129 29, .548 1, .00 36 .96 1SG3141
ATOM 3141 O ILE 402 66 .186 40, .601 29, .764 1, .00 36 .96 1SG3142
ATOM 3142 N LEU 403 64, .915 38, .980 28, .869 1, .00 36 .78 1SG3143
ATOM 3143 CA LEU 403 66, .073 38, .243 28. .451 1, .00 36, .78 1SG3144
ATOM 3144 CB LEU 403 65 .759 36 .899 27 .768 1 .00 36 .78 1SG3145
ATOM 3145 CG LEU 403 65 .274 35, .812 28. .744 1 .00 36 .78 1SG3146
ATOM 3146 CD2 LEU 403 66, .268 35, .622 29. .901 1 .00 36 .78 1SG3147
ATOM 3147 CDl LEU 403 64, .982 34, .497 28. .012 1, .00 36 .78 1SG3148
ATOM 3148 C LEU 403 66, .881 39, .056 27. .493 1, .00 36 .78 1SG3149
ATOM 3149 O LEU 403 68, .105 38, .954 27. .466 1, .00 36, .78 1SG3150
ATOM 3150 N SER 404 66, .212 39. .862 26. .654 1, .00 38, .39 1SG3151
ATOM 3151 CA SER 404 66 .894 40 .640 25. .662 1, .00 38 .39 1SG3152
ATOM 3152 CB SER 404 65 .921 41. .403 24. .749 1, .00 38 .39 1SG3153
ATOM 3153 OG SER 404 66 .640 42, .158 23, .786 1, .00 38 .39 1SG3154
ATOM 3154 C SER 404 67, .785 41, .651 26. .311 1, .00 38, .39 1SG3155
ATOM 3155 O SER 404 68, .845 41, .964 25. .779 1, .00 38, .39 1SG3156
ATOM 3156 N SER 405 67, .344 42. .241 27. .437 1, .00 40, .07 1SG3157
ATOM 3157 CA SER 405 68 .113 43 .242 28, .125 1, .00 40 .07 1SG3158
ATOM 3158 CB SER 405 67 .252 44, .051 29. .110 1, .00 40, .07 1SG3159
ATOM 3159 OG SER 405 68, .050 45, .024 29. .769 1, .00 40, .07 1SG3160
ATOM 3160 C SER 405 69, .247 42, .656 28. .913 1, .00 40, .07 1SG3161
ATOM 3161 O SER 405 70, .407 43. .025 28. .729 1. .00 40, .07 1SG3162
ATOM 3162 N ILE 406 68. .934 41. .704 29. .819 1. .00 43, .47 1SG3163
ATOM 3163 CA ILE 406 69. .914 41. .202 30. .735 1. .00 43, .47 1SG3164
ATOM 3164 CB ILE 406 69, .367 40, .229 31. .743 1. .00 43, .47 1SG3165
ATOM 3165 CG2 ILE 406 70, .572 39, .570 32. .435 1. .00 43, .47 1SG3166
ATOM 3166 CGI ILE 406 68, .435 40, .939 32. .746 1. .00 43. .47 1SG3167
ATOM 3167 CDl ILE 406 67, .157 41, .528 32. .154 1. .00 43. .47 1SG3168
ATOM 3168 C ILE 406 71. .045 40. .539 30. .023 1. .00 43. .47 1SG3169
ATOM 3169 O ILE 406 72. .205 40. .766 30. .363 1. ,00 43. .47 1SG3170
ATOM 3170 N LEU 407 70. .751 39, .710 29. .010 1. .00 46. .00 1SG3171
ATOM 3171 CA LEU 407 71. .800 38, .964 28. .383 1. .00 46. .00 1SG3172
ATOM 3172 CB LEU 407 71. .234 38. .057 27. ,264 1. .00 46. .00 1SG3173
ATOM 3173 CG LEU 407 72. .180 36. .997 26. ,648 1. .00 46. .00 1SG3174
ATOM 3174 CD2 LEU 407 73. .503 37. ,578 26. ,124 1. .00 46. ,00 1SG3175
ATOM 3175 CDl LEU 407 71. .443 36. ,195 25. ,563 1. .00 46. .00 1SG3176
ATOM 3176 C LEU 407 72, .821 39. .897 27. ,784 1. .00 46. .00 1SG3177 ATOM 3177 O LEU 407 74..002 39..824 28..116 1..00 46..00 1SG3178
ATOM 3178 N HIS 408 72. .409 40. .823 26. .902 1. ,00 49. .00 1SG3179
ATOM 3179 CA HIS 408 73, .391 41. .656 26. .269 1. .00 49. .00 1SG3180
ATOM 3180 NDl HIS 408 71, .232 41. .580 23. .460 1. .00 49. .00 1SG3181
ATOM 3181 CG HIS 408 72, .508 41. .878 23. .884 1. .00 49. .00 1SG3182
ATOM 3182 CB HIS 408 72, .834 42. .575 25. .168 1. ,00 49. .00 1SG3183
ATOM 3183 NE2 HIS 408 72, .614 40. .854 21, .877 1. .00 49. .00 1SG3184
ATOM 3184 CD2 HIS 408 73, .339 41. .427 22. .906 1. .00 49. .00 1SG3185
ATOM 3185 CE1 HIS 408 71, .354 40. .970 22. .255 1. .00 49. .00 1SG3186
ATOM 3186 C HIS 408 74 .042 42, .569 27, .254 1, .00 49. .00 1SG3187
ATOM 3187 O HIS 408 75, .250 42. .775 27. .200 1. .00 49. .00 1SG3188
ATOM 3188 N PHE 409 73 .256 43. .210 28. .135 1. .00 52, .22 1SG3189
ATOM 3189 CA PHE 409 73 .862 44. .151 29. .027 1, .00 52, .22 1SG3190
ATOM 3190 CB PHE 409 72, .818 45. .008 29. .768 1. .00 52. .22 1SG3191
ATOM 3191 CG PHE 409 73, .536 46. .025 30. .592 1. .00 52. .22 1SG3192
ATOM 3192 CDl PHE 409 73 .994 45, .721 31, .854 1. .00 52 .22 1SG3193
ATOM 3193 CD2 PHE 409 73. .745 47, .293 30, .099 1. .00 52 .22 1SG3194
ATOM 3194 CE1 PHE 409 74, .653 46. .663 32. .608 1. .00 52. .22 1SG3195
ATOM 3195 CE2 PHE 409 74 .403 48, .239 30. .849 1. .00 52 .22 1SG3196
ATOM 3196 CZ PHE 409 74 .860 47, .925 32, .106 1. .00 52, .22 1SG3197
ATOM 3197 C PHE 409 74 .704 43, .484 30 .072 1 .00 52 .22 1SG3198
ATOM 3198 0 PHE 409 75, .868 43. .835 30. .251 1. .00 52. .22 1SG3199
ATOM 3199 N GLY 410 74 .103 42. .558 30. .848 1. .00 51. .84 1SG3200
ATOM 3200 CA GLY 410 74. .812 41. .933 31. .930 1. .00 51. .84 1SG3201
ATOM 3201 C GLY 410 75 .759 40, .824 31. .572 1. .00 51 .84 1SG3202
ATOM 3202 O GLY 410 76 .921 40. .853 31, .970 1, .00 51 .84 1SG3203
ATOM 3203 N VAL 411 75. .260 39. .779 30. .871 1, .00 52. .43 1SG3204
ATOM 3204 CA VAL 411 76 .060 38, .600 30. .656 1, .00 52 .43 1SG3205
ATOM 3205 CB VAL 411 75, .266 37, .323 30. .545 1, .00 52, .43 1SG3206
ATOM 3206 CGI VAL 411 74, .647 37, .041 31 .923 1 .00 52 .43 1SG3207
ATOM 3207 CG2 VAL 411 74, .211 37. .443 29. .443 1. .00 52. .43 1SG3208
ATOM 3208 C VAL 411 77 .105 38. .657 29. .579 1. .00 52, .43 1SG3209
ATOM 3209 0 VAL 411 78, .244 38. .254 29. .804 1. .00 52, .43 1SG3210
ATOM 3210 N LEU 412 76 .775 39, .168 28. .382 1, .00 48 .60 1SG3211
ATOM 3211 CA LEU 412 77 .714 39. .090 27. .298 1, .00 48, .60 1SG3212
ATOM 3212 CB LEU 412 77, .175 39. .619 25. .961 1, .00 48, .60 1SG3213
ATOM 3213 CG LEU 412 78 .139 39, .309 24, .801 1, .00 48 .60 1SG3214
ATOM 3214 CD2 LEU 412 77 .759 40, .058 23, .520 1, .00 48, .60 1SG3215
ATOM 3215 CDl LEU 412 78, .256 37. .793 24. .581 1, .00 48, .60 1SG3216
ATOM 3216 C LEU 412 78. .972 39. .846 27. .609 1. .00 48. .60 1SG3217
ATOM 3217 0 LEU 412 80. .057 39. .372 27. .273 1. .00 48. .60 1SG3218
ATOM 3218 N PRO 413 78, .909 40. .989 28, .234 1. .00 42. .66 1SG3219
ATOM 3219 CA PRO 413 80. .114 41. .729 28. .463 1. .00 42. .66 1SG3220
ATOM 3220 CD PRO 413 77 .762 41. .874 28, .111 1, .00 42, .66 1SG3221
ATOM 3221 CB PRO 413 79, .673 43. .085 29, .004 1. .00 42. .66 1SG3222
ATOM 3222 CG PRO 413 78 .301 43. .296 28, .338 1. .00 42, .66 1SG3223
ATOM 3223 C PRO 413 81. .146 41. .029 29. .286 1. .00 42, .66 1SG3224
ATOM 3224 0 PRO 413 82. .331 41. .224 29, .020 1. .00 42: .66 1SG3225
ATOM 3225 N LEU 414 80, .750 40. .230 30. .292 1. .00 37. .15 1SG3226
ATOM 3226 CA LEU 414 81, .750 39. .581 31. .085 1, .00 37. .15 1SG3227
ATOM 3227 CB LEU 414 81, .194 38. .932 32. .375 1. .00 37. .15 1SG3228
ATOM 3228 CG LEU 414 80, .278 37. .704 32. ,199 1. .00 37. .15 1SG3229
ATOM 3229 CD2 LEU 414 79, .428 37. .470 33. .459 1. .00 37. .15 1SG3230
ATOM 3230 CDl LEU 414 81, .064 36. .450 31. .784 1. .00 37. .15 1SG3231
ATOM 3231 C LEU 414 82, .448 38. .553 30. .249 1, .00 37. .15 1SG3232
ATOM 3232 0 LEU 414 83. .664 38. 390 30. .341 1. ,00 37. .15 1SG3233
ATOM 3233 N ALA 415 81, .686 37. .831 29. .405 1. .00 31. .31 1SG3234 ATOM 3234 CA ALA 415 82.235 36.769 28,.611 1,.00 31,.31 1SG3235
ATOM 3235 CB ALA 415 81 .162 36 .034 27, .788 1, .00 31, .31 1SG3236
ATOM 3236 C ALA 415 83 .241 37 .300 27 .642 1, .00 31, .31 1SG3237
ATOM 3237 0 ALA 415 84. .334 36 .756 27 .508 1, .00 31 .31 1SG3238
ATOM 3238 N ASN 416 82 .902 38 .407 26, .962 1, .00 29, .80 1SG3239
ATOM 3239 CA ASN 416 83 .744 38 .966 25, .947 1, .00 29, .80 1SG3240
ATOM 3240 CB ASN 416 83 .099 40 .161 25 .229 1 .00 29, .80 1SG3241
ATOM 3241 CG ASN 416 81. .953 39 .606 24 .396 1 .00 29 .80 1SG3242
ATOM 3242 ODl ASN 416 81, ,779 38 .392 24, .295 1. .00 29, .80 1SG3243
ATOM 3243 ND2 ASN 416 81, ,155 40 .513 23, .771 1, .00 29, .80 1SG3244
ATOM 3244 C ASN 416 85 .027 39 .405 26. .564 1, .00 29, .80 1SG3245
ATOM 3245 0 ASN 416 86 .060 39 .430 25 .900 1, .00 29 .80 1SG3246
ATOM 3246 N ALA 417 84, ,995 39. .782 27, .853 1. .00 29, .81 1SG3247
ATOM 3247 CA ALA 417 86, ,184 40. .262 28. .488 1. .00 29, .81 1SG3248
ATOM 3248 CB ALA 417 85 ,962 40 .627 29. .966 1, .00 29, .81 1SG3249
ATOM 3249 C ALA 417 87 ,230 39 .193 28, .444 1. .00 29, .81 1SG3250
ATOM 3250 O ALA 417 88, ,391 39, .479 28, .157 1. .00 29 .81 1SG3251
ATOM 3251 N LYS 418 86, .867 37, .929 28, .738 1. .00 31, .75 1SG3252
ATOM 3252 CA LYS 418 87, ,879 36 .914 28, .702 1. .00 31, .75 1SG3253
ATOM 3253 CB LYS 418 87, ,470 35 .561 29, .307 1, .00 31, .75 1SG3254
ATOM 3254 CG LYS 418 88, ,694 34, .668 29, .540 1, .00 31, .75 1SG3255
ATOM 3255 CD LYS 418 88, ,453 33, .494 30, .489 1. .00 31. .75 1SG3256
ATOM 3256 CE LYS 418 89, .742 32, .811 30, .963 1. .00 31. .75 1SG3257
ATOM 3257 NZ LYS 418 90 .439 32 .169 29 .827 1, .00 31 .75 1SG3258
ATOM 3258 C LYS 418 88, .317 36 .674 27 .289 1 .00 31 .75 1SG3259
ATOM 3259 O LYS 418 89, .506 36 .508 27, .023 1, .00 31. .75 1SG3260
ATOM 3260 N LEU 419 87 .366 36 .659 26 .336 1, .00 33. .00 1SG3261
ATOM 3261 CA LEU 419 87 .716 36 .398 24 .967 1, .00 33 .00 1SG3262
ATOM 3262 CB LEU 419 86, .513 36 .311 24 .007 1, .00 33 .00 1SG3263
ATOM 3263 CG LEU 419 85, .677 35, .024 24, .171 1. .00 33. .00 1SG3264
ATOM 3264 CD2 LEU 419 84 , .753 34 .800 22, .968 1, .00 33. .00 1SG3265
ATOM 3265 CDl LEU 419 84, .926 34 .985 25 .507 1, .00 33. .00 1SG3266
ATOM 3266 C LEU 419 88, .634 37 .472 24 .481 1, .00 33. .00 1SG3267
ATOM 3267 O LEU 419 89. .559 37, .205 23, .715 1. .00 33. .00 1SG3268
ATOM 3268 N GLN 420 88. .392 38, .724 24, .904 1. .00 32. .88 1SG3269
ATOM 3269 CA GLN 420 89. .231 39, .820 24, .518 1. .00 32. .88 1SG3270
ATOM 3270 CB GLN 420 88, .693 41, .187 24, .971 1. .00 32. .88 1SG3271
ATOM 3271 CG GLN 420 87. .422 41, .592 24. .222 1. .00 32, .88 1SG3272
ATOM 3272 CD GLN 420 87. .781 41, .686 22. .745 1. ,00 32. .88 1SG3273
ATOM 3273 OEl GLN 420 87. .205 40, .994 21. .907 1. .00 32. .88 1SG3274
ATOM 3274 NE2 GLN 420 88. .768 42, .560 22. .414 1. .00 32. .88 1SG3275
ATOM 3275 C GLN 420 90. .584 39. .616 25. .122 1. .00 32. .88 1SG3276
ATOM 3276 O GLN 420 91. .594 40. .004 24. .537 1. .00 32. ,88 1SG3277
ATOM 3277 N GLN 421 90. ,643 39. .016 26. .326 1. .00 33. ,95 1SG3278
ATOM 3278 CA GLN 421 91. ,913 38. .786 26. .951 1. .00 33. ,95 1SG3279
ATOM 3279 CB GLN 421 91. .778 38. .053 28. .296 1. .00 33. .95 1SG3280
ATOM 3280 CG GLN 421 91. .024 38, ,870 29, .346 1. ,00 33. ,95 1SG3281
ATOM 3281 CD GLN 421 90. .949 38, .049 30, .625 1. .00 33. ,95 1SG3282
ATOM 3282 OEl GLN 421 91. .367 36, .893 30, .662 1. .00 33. ,95 1SG3283
ATOM 3283 NE2 GLN 421 90. .395 38. .662 31, .705 1. .00 33. .95 1SG3284
ATOM 3284 C GLN 421 92. .674 37. .903 26. .020 1. .00 33. ,95 1SG3285
ATOM 3285 O GLN 421 93. .849 38. .138 25. .747 1. ,00 33. 95 1SG3286
ATOM 3286 N GLY 422 91. .995 36. .871 25. .485 1. ,00 36. 89 1SG3287
ATOM 3287 CA GLY 422 92. .590 36. .034 24. .487 1. ,00 36. ,89 1SG3288
ATOM 3288 C GLY 422 93. 270 34. ,854 25. .097 1. ,00 36. ,89 1SG3289
ATOM 3289 O GLY 422 93. 239 34. ,636 26. .308 1. 00 36. 89 1SG3290
ATOM 3290 N PHE 423 93. 891 34. .046 24. ,213 1. 00 42. 31 1SG3291 ATOM 3291 CA PHE 423 94..613 32..876 24..601 1.,00 42.,31 1SG3292
ATOM 3292 CB PHE 423 94. ,012 31. .565 24. ,059 1. ,00 42. ,31 1SG3293
ATOM 3293 CG PHE 423 92. ,669 31. .373 24. .682 1. ,00 42. ,31 1SG3294
ATOM 3294 CDl PHE 423 92. .560 31. .027 26. .009 1. .00 42. .31 1SG3295
ATOM 3295 CD2 PHE 423 91. .518 31. .515 23. .940 1. .00 42. .31 1SG3296
ATOM 3296 CE1 PHE 423 91. .327 30, .843 26. .589 1. ,00 42. .31 1SG3297
ATOM 3297 CE2 PHE 423 90. .281 31, .332 24. .514 1. ,00 42. .31 1SG3298
ATOM 3298 CZ PHE 423 90. .183 30. .997 25. .843 1. .00 42. .31 1SG3299
ATOM 3299 C PHE 423 95, .983 33. .014 24, .015 1. .00 42, .31 1SG3300
ATOM 3300 O PHE 423 96, .168 33, .596 22, .947 1. .00 42 , .31 1SG3301
ATOM 3301 N PRO 424 96, .953 32, .497 24. .716 1. .00 47. .73 1SG3302
ATOM 3302 CA PRO 424 98. .309 32 , .603 24. .253 1. .00 47. .73 1SG3303
ATOM 3303 CD PRO 424 96. .876 32 , .499 26. .168 1. .00 47. .73 1SG3304
ATOM 3304 CB PRO 424 99. .187 32, .262 25. .454 1. .00 47. .73 1SG3305
ATOM 3305 CG PRO 424 98, .322 32 .675 26. .659 1. .00 47. .73 1SG3306
ATOM 3306 C PRO 424 98, .571 31, .760 23, .046 1. .00 47. .73 1SG3307
ATOM 3307 0 PRO 424 98. .011 30, .669 22, .939 1. .00 47, .73 1SG3308
ATOM 3308 N LEU 425 99. .432 32, .247 22 , .131 1. .00 53 , .92 1SG3309
ATOM 3309 CA LEU 425 99. .742 31, .503 20. .948 1. .00 53, .92 1SG3310
ATOM 3310 CB LEU 425 99. .769 32 .361 19. .673 1. .00 53 .92 1SG3311
ATOM 3311 CG LEU 425 98, .376 32 .960 19 .382 1, .00 53 .92 1SG3312
ATOM 3312 CD2 LEU 425 97, .271 31 .901 19 .526 1, .00 53 .92 1SG3313
ATOM 3313 CDl LEU 425 98, .322 33, .683 18. .032 1. .00 53, .92 1SG3314
ATOM 3314 C LEU 425 101. .068 30, .843 21. .164 1. .00 53 .92 1SG3315
ATOM 3315 0 LEU 425 101. .857 31, .279 22, .001 1, .00 53. .92 1SG3316
ATOM 3316 N SER 426 101. .342 29 .742 20 .432 1. .00 57 .50 1SG3317
ATOM 3317 CA SER 426 102. .563 29 .041 20 .708 1, .00 57 .50 1SG3318
ATOM 3318 CB SER 426 102. .552 27 .569 20, .258 1, .00 57 .50 1SG3319
ATOM 3319 OG SER 426 103. .786 26 .948 20, .588 1, .00 57 .50 1SG3320
ATOM 3320 C SER 426 103. .689 29 .711 19, .996 1, .00 57, .50 1SG3321
ATOM 3321 O SER 426 104. .107 29, .287 18, .920 1, .00 57 .50 1SG3322
ATOM 3322 N ASN 427 104 .247 30 .761 20 .626 1 .00 61 .39 1SG3323
ATOM 3323 CA ASN 427 105. .347 31 .466 20 .035 1, .00 61 .39 1SG3324
ATOM 3324 CB ASN 427 105, .067 32 .959 19 .787 1, .00 61 .39 1SG3325
ATOM 3325 CG ASN 427 104, .785 33 .620 21 .128 1, .00 61 .39 1SG3326
ATOM 3326 ODl ASN 427 103, .897 33, .193 21, .864 1, .00 61 .39 1SG3327
ATOM 3327 ND2 ASN 427 105. .560 34 .689 21. .458 1, .00 61 .39 1SG3328
ATOM 3328 C ASN 427 106, .507 31 .373 20 .976 1 .00 61 .39 1SG3329
ATOM 3329 0 ASN 427 106, .357 31 .331 22 .194 1, .00 61 .39 1SG3330
ATOM 3330 N PRO 428 107, .671 31 .347 20 .393 1, .00 67 .43 1SG3331
ATOM 3331 CA PRO 428 108, .903 31 .266 21 .132 1, .00 67 .43 1SG3332
ATOM 3332 CD PRO 428 107, .804 30, .801 19. .053 1, .00 67, .43 1SG3333
ATOM 3333 CB PRO 428 109, .986 30 .936 20 .111 1 .00 67 .43 1SG3334
ATOM 3334 CG PRO 428 109. .224 30 .219 18 .987 1 .00 67 .43 1SG3335
ATOM 3335 C PRO 428 109, .152 32 .576 21 .812 1 .00 67 .43 1SG3336
ATOM 3336 0 PRO 428 108, .345 33 .492 21 .671 1, .00 67, .43 1SG3337
ATOM 3337 N HIS 429 110, .269 32, .663 22, .556 1, .00 69, .76 1SG3338
ATOM 3338 CA HIS 429 110. .667 33, .776 23, .372 1, .00 69, .76 1SG3339
ATOM 3339 NDl HIS 429 113. .603 34 .465 25 .729 1 .00 69 .76 1SG3340
ATOM 3340 CG HIS 429 112. .496 34 .621 24 .923 1 .00 69, .76 1SG3341
ATOM 3341 CB HIS 429 112, .143 33 .690 23 .801 1, .00 69. .76 1SG3342
ATOM 3342 NE2 HIS 429 112 , .547 36 .286 26 .446 1, .00 69. .76 1SG3343
ATOM 3343 CD2 HIS 429 111, .863 35, .739 25, .374 1, .00 69. .76 1SG3344
ATOM 3344 CE1 HIS 429 113, .584 35 .487 26 .622 1, .00 69 .76 1SG3345
ATOM 3345 C HIS 429 110, .449 35 .107 22 .711 1, .00 69 .76 1SG3346
ATOM 3346 0 HIS 429 109, .333 35 .603 22, .677 1, .00 69. .76 1SG3347
ATOM 3347 N LYS 430 111, .521 35, .707 22, .164 1, .00 71. .88 1SG3348 ATOM 3348 CA LYS 430 111..678 37..053 21..658 1.,00 71..88 1SG3349
ATOM 3349 CB LYS 430 113. .107 37. .260 21. .144 1. ,00 71. .88 1SG3350
ATOM 3350 CG LYS 430 113. .644 35. .998 20. .470 1. ,00 71. .88 1SG3351
ATOM 3351 CD LYS 430 112. .815 35. .542 19. .270 1. .00 71. .88 1SG3352
ATOM 3352 CE LYS 430 113. .166 34. .128 18. .805 1. .00 71. .88 1SG3353
ATOM 3353 NZ LYS 430 112. .403 33. .793 17. .584 1. .00 71. .88 1SG3354
ATOM 3354 C LYS 430 110. .739 37. .469 20. .553 1. .00 71. .88 1SG3355
ATOM 3355 O LYS 430 110. .558 38. .667 20. .336 1. .00 71. .88 1SG3356
ATOM 3356 N PHE 431 110. .175 36. .522 19. .786 1. .00 68. .75 1SG3357
ATOM 3357 CA PHE 431 109. .359 36. .777 18. .623 1. .00 68. .75 1SG3358
ATOM 3358 CB PHE 431 109. .116 35. .456 17, .880 1. .00 68. .75 1SG3359
ATOM 3359 CG PHE 431 107. .881 35. .527 17, .065 1. .00 68, .75 1SG3360
ATOM 3360 CDl PHE 431 107. .853 36, .194 15. .869 1. .00 68, .75 1SG3361
ATOM 3361 CD2 PHE 431 106. .737 34 , .926 17. .532 1. .00 68, .75 1SG3362
ATOM 3362 CE1 PHE 431 106. .700 36, .238 15. .127 1. .00 68, .75 1SG3363
ATOM 3363 CE2 PHE 431 105. .579 34, .965 16. .800 1. .00 68, .75 1SG3364
ATOM 3364 CZ PHE 431 105. .569 35, .617 15. .594 1. .00 68, .75 1SG3365
ATOM 3365 C PHE 431 108. .041 37, .469 18, .878 1. .00 68 .75 1SG3366
ATOM 3366 O PHE 431 107. .414 37, .322 19, .924 1. .00 68, .75 1SG3367
ATOM 3367 N LEU 432 107, .610 38, .290 17, .885 1. .00 60, .05 1SG3368
ATOM 3368 CA LEU 432 106, .340 38, .970 17, .896 1. .00 60 .05 1SG3369
ATOM 3369 CB LEU 432 106. .426 40, .472 18, .219 1. .00 60 .05 1SG3370
ATOM 3370 CG LEU 432 106, .904 40, .783 19, .649 1, .00 60 .05 1SG3371
ATOM 3371 CD2 LEU 432 106, .659 42, .258 20, .004 1, .00 60 .05 1SG3372
ATOM 3372 CDl LEU 432 108, .362 40, .347 19, .867 1. .00 60 .05 1SG3373
ATOM 3373 C LEU 432 105, .792 38, .859 16, .503 1, .00 60 .05 1SG3374
ATOM 3374 O LEU 432 106, .547 38 .943 15, .536 1, .00 60 .05 1SG3375
ATOM 3375 N PHE 433 104, .463 38, .667 16, .340 1, .00 52 .49 1SG3376
ATOM 3376 CA PHE 433 104, .005 38, .550 14, .986 1. .00 52 .49 1SG3377
ATOM 3377 CB PHE 433 103, .323 37, .223 14, .610 1, .00 52 .49 1SG3378
ATOM 3378 CG PHE 433 102, .210 36, .923 15, .536 1. .00 52 .49 1SG3379
ATOM 3379 CDl PHE 433 102 .466 36, .330 16, .751 1. .00 52 .49 1SG3380
ATOM 3380 CD2 PHE 433 100, .923 37, .232 15, .185 1. .00 52 .49 1SG3381
ATOM 3381 CE1 PHE 433 101. .443 36, .041 17, .619 1. .00 52 .49 1SG3382
ATOM 3382 CE2 PHE 433 99, .903 36, .942 16, .049 1. .00 52 .49 1SG3383
ATOM 3383 CZ PHE 433 100, .154 36 .348 17 .263 1. .00 52 .49 1SG3384
ATOM 3384 C PHE 433 103. .172 39 .716 14 .584 1. .00 52 .49 1SG3385
ATOM 3385 O PHE 433 102, .443 40, .299 15 .386 1, .00 52 .49 1SG3386
ATOM 3386 N VAL 434 103, .310 40 .098 13 .297 1, .00 42 .69 1SG3387
ATOM 3387 CA VAL 434 102, .646 41, .252 12, .767 1, .00 42 .69 1SG3388
ATOM 3388 CB VAL 434 103, .597 42, .423 12 .686 1, .00 42 .69 1SG3389
ATOM 3389 CGI VAL 434 102, .900 43 .673 12 .116 1, .00 42 .69 1SG3390
ATOM 3390 CG2 VAL 434 104, .195 42, .638 14 .085 1, .00 42 .69 1SG3391
ATOM 3391 C VAL 434 102, .167 40, .893 11 .386 1, .00 42 .69 1SG3392
ATOM 3392 O VAL 434 102. .518 39, .840 10 .852 1, .00 42 .69 1SG3393
ATOM 3393 N ASN 435 101, .335 41, .765 10, .774 1, .00 37 .91 1SG3394
ATOM 3394 CA ASN 435 100, .825 41, .561 9 .448 1, .00 37 .91 1SG3395
ATOM 3395 CB ASN 435 101, .911 41, .666 8 .359 1, .00 37 .91 1SG3396
ATOM 3396 CG ASN 435 102, .382 43, .113 8, .298 1, .00 37 .91 1SG3397
ATOM 3397 ODl ASN 435 101, .660 44, .032 8 .679 1, .00 37 .91 1SG3398
ATOM 3398 ND2 ASN 435 103, .630 43, .323 7 .799 1, .00 37 .91 1SG3399
ATOM 3399 C ASN 435 100, .204 40, .204 9, .356 1, .00 37 .91 1SG3400
ATOM 3400 O ASN 435 100, .637 39, .367 8, .567 1, .00 37 .91 1SG3401
ATOM 3401 N SER 436 99, .161 39, .955 10, .172 1, .00 36 .62 1SG3402
ATOM 3402 CA SER 436 98, .543 38, .661 10, .184 1, .00 36 .62 1SG3403
ATOM 3403 CB SER 436 98, .164 38, .178 11, .595 1, .00 36 .62 1SG3404
ATOM 3404 OG SER 436 99. .332 38, .024 12, .387 1. .00 36 .62 1SG3405 ATOM 3405 C SER 436 97.,287 38,.664 9..369 1..00 36..62 1SG3406
ATOM 3406 O SER 436 96. ,648 39. .697 9. .171 1. .00 36. .62 1SG3407
ATOM 3407 N ASP 437 96. .927 37. .470 8. .851 1. .00 36. .84 1SG3408
ATOM 3408 CA ASP 437 95. .729 37. .289 8. .083 1. .00 36. .84 1SG3409
ATOM 3409 CB ASP 437 95. .988 37, .009 6. .593 1, .00 36. .84 1SG3410
ATOM 3410 CG ASP 437 94. .653 37, .052 5. .863 1. .00 36. .84 1SG3411
ATOM 3411 ODl ASP 437 93. .621 37, .336 6. .528 1. .00 36. .84 1SG3412
ATOM 3412 OD2 ASP 437 94. .647 36, .800 4. .628 1. .00 36. .84 1SG3413
ATOM 3413 C ASP 437 95. .028 36, .089 8. .641 1, .00 36. .84 1SG3414
ATOM 3414 O ASP 437 95. .651 35, .055 8. .876 1 .00 36. .84 1SG3415
ATOM 3415 N ILE 438 93. .705 36, .198 8. .889 1. .00 39, .90 1SG3416
ATOM 3416 CA ILE 438 93. .003 35, .062 9. .400 1. .00 39, .90 1SG3417
ATOM 3417 CB ILE 438 92. .306 35, .340 10, .717 1, .00 39. .90 1SG3418
ATOM 3418 CG2 ILE 438 93. .411 35, .742 11, .707 1. .00 39. .90 1SG3419
ATOM 3419 CGI ILE 438 91. .181 36. .394 10, .636 1. .00 39, .90 1SG3420
ATOM 3420 CDl ILE 438 89. .804 35, .852 10, .248 1. .00 39, .90 1SG3421
ATOM 3421 C ILE 438 92. .043 34, .637 8, .334 1. .00 39, .90 1SG3422
ATOM 3422 O ILE 438 91. .155 35 .385 7 .930 1. .00 39, .90 1SG3423
ATOM 3423 N GLU 439 92. .230 33 .414 7. .805 1. .00 41, .08 1SG3424
ATOM 3424 CA GLU 439 91. .357 32, .953 6, .769 1, .00 41, .08 1SG3425
ATOM 3425 CB GLU 439 92. .092 32 .419 5, .528 1, .00 41, .08 1SG3426
ATOM 3426 CG GLU 439 92, .831 33 .491 4 .726 1 .00 41, .08 1SG3427
ATOM 3427 CD GLU 439 93, .500 32 .801 3, .546 1, .00 41 .08 1SG3428
ATOM 3428 OEl GLU 439 93, .317 31, .561 3, .409 1, .00 41, .08 1SG3429
ATOM 3429 OE2 GLU 439 94. .201 33 .500 2 .767 1 .00 41 .08 1SG3430
ATOM 3430 C GLU 439 90. .598 31 .813 7 .340 1, .00 41, .08 1SG3431
ATOM 3431 O GLU 439 91. .184 30 .859 7, .848 1, .00 41, .08 1SG3432
ATOM 3432 N VAL 440 89. .259 31, .879 7, .284 1, .00 42, .29 1SG3433
ATOM 3433 CA VAL 440 88 .524 30 .789 7 .827 1 .00 42 .29 1SG3434
ATOM 3434 CB VAL 440 87. .132 31 .132 8, .189 1 .00 42 .29 1SG3435
ATOM 3435 CGI VAL 440 86. .416 31 .698 6, .952 1, .00 42, .29 1SG3436
ATOM 3436 CG2 VAL 440 86. .524 29 .825 8, .684 1, .00 42, .29 1SG3437
ATOM 3437 C VAL 440 88. .451 29 .715 6 .793 1 .00 42. .29 1SG3438
ATOM 3438 O VAL 440 88. .345 29 .989 5, .599 1, .00 42, .29 1SG3439
ATOM 3439 N LEU 441 88. .527 28 .449 7, .242 1, .00 42, .17 1SG3440
ATOM 3440 CA LEU 441 88. .440 27, .339 6, .341 1, .00 42, .17 1SG3441
ATOM 3441 CB LEU 441 89. .780 26 .643 6 .051 1 .00 42 .17 1SG3442
ATOM 3442 CG LEU 441 90. .760 27 .546 5, .277 1, .00 42, .17 1SG3443
ATOM 3443 CD2 LEU 441 91. .910 26, .746 4 , .646 1, .00 42, .17 1SG3444
ATOM 3444 CDl LEU 441 91 .245 28 .711 6 .148 1 .00 42 .17 1SG3445
ATOM 3445 C LEU 441 87. .501 26 .349 6, .941 1 .00 42, .17 1SG3446
ATOM 3446 O LEU 441 86. .958 26 .566 8, .023 1, .00 42, .17 1SG3447
ATOM 3447 N GLU 442 87, .257 25, .231 6, .232 1, .00 42. .95 1SG3448
ATOM 3448 CA GLU 442 86 .321 24 .287 6, .759 1, .00 42, .95 1SG3449
ATOM 3449 CB GLU 442 85, .743 23 .307 5, .723 1, .00 42, .95 1SG3450
ATOM 3450 CG GLU 442 86, .797 22. .426 5. .056 1, .00 42, .95 1SG3451
ATOM 3451 CD GLU 442 87, .503 23. .283 4. .020 1, .00 42. .95 1SG3452
ATOM 3452 OEl GLU 442 87, .005 24 .411 3, .757 1, .00 42. .95 1SG3453
ATOM 3453 OE2 GLU 442 88, .542 22. .825 3, .474 1, .00 42. .95 1SG3454
ATOM 3454 C GLU 442 86, .982 23, .477 7. .825 1. .00 42. .95 1SG3455
ATOM 3455 O GLU 442 87, .928 22. .730 7. .576 1. .00 42. .95 1SG3456
ATOM 3456 N GLY 443 86, .477 23. .629 9. .062 1, .00 43. .53 1SG3457
ATOM 3457 CA GLY 443 86, .920 22. .843 10, .173 1, .00 43. .53 1SG3458
ATOM 3458 C GLY 443 88. .118 23. .444 10. .845 1. .00 43. .53 1SG3459
ATOM 3459 O GLY 443 88. .554 22 .932 11, .877 1. .00 43, .53 1SG3460
ATOM 3460 N PHE 444 88, .704 24. .528 10. .299 1. .00 44. .62 1SG3461
ATOM 3461 CA PHE 444 89, .847 25, .072 10. .981 1. .00 44. .62 1SG3462 ATOM 3462 CB PHE 444 91..159 24..304 10..726 1..00 44..62 1SG3463
ATOM 3463 CG PHE 444 91. .558 24. .417 9. .292 1. .00 44, .62 1SG3464
ATOM 3464 CDl PHE 444 90, .975 23, .624 8. .329 1. .00 44, .62 1SG3465
ATOM 3465 CD2 PHE 444 92, .536 25 .308 8 .910 1. .00 44 .62 1SG3466
ATOM 3466 CE1 PHE 444 91. .354 23. .723 7. .011 1. .00 44. .62 1SG3467
ATOM 3467 CE2 PHE 444 92. .919 25, .413 7, .594 1. .00 44. .62 1SG3468
ATOM 3468 CZ PHE 444 92, .327 24, .619 6 .642 1. .00 44 .62 1SG3469
ATOM 3469 C PHE 444 90, .057 26 .488 10 .550 1. .00 44 .62 1SG3470
ATOM 3470 O PHE 444 89, .509 26, .934 9 .543 1, .00 44. .62 1SG3471
ATOM 3471 N LEU 445 90, .853 27, .244 11, .335 1. .00 45, .68 1SG3472
ATOM 3472 CA LEU 445 91, .098 28, .636 11, .077 1, .00 45, .68 1SG3473
ATOM 3473 CB LEU 445 90, .863 29 .476 12 .350 1. .00 45 .68 1SG3474
ATOM 3474 CG LEU 445 90, .896 31, .007 12, .190 1, .00 45 .68 1SG3475
ATOM 3475 CD2 LEU 445 89. .731 31. .505 11, .328 1. .00 45, .68 1SG3476
ATOM 3476 CDl LEU 445 92, .264 31. .511 11, .723 1. .00 45, .68 1SG3477
ATOM 3477 C LEU 445 92, .537 28 .774 10 .660 1. .00 45 .68 1SG3478
ATOM 3478 O LEU 445 93. .429 28. .184 11 .268 1 .00 45 .68 1SG3479
ATOM 3479 N LEU 446 92. .804 29. .561 9 .595 1. .00 44 .75 1SG3480
ATOM 3480 CA LEU 446 94. .165 29. .698 9, .152 1, .00 44 .75 1SG3481
ATOM 3481 CB LEU 446 94, .326 29. .660 7 .618 1. .00 44 .75 1SG3482
ATOM 3482 CG LEU 446 95, .792 29 .787 7 .157 1 .00 44 .75 1SG3483
ATOM 3483 CD2 LEU 446 95, .907 29. .963 5 .634 1, .00 44 .75 1SG3484
ATOM 3484 CDl LEU 446 96, .623 28. .606 7. .676 1, .00 44 .75 1SG3485
ATOM 3485 C LEU 446 94, .687 31. .017 9 .629 1, .00 44 .75 1SG3486
ATOM 3486 O LEU 446 94, .079 32. .061 9 .393 1 .00 44 .75 1SG3487
ATOM 3487 N ILE 447 95, .838 30. .992 10, .335 1, .00 44 .56 1SG3488
ATOM 3488 CA ILE 447 96 .434 32. .200 10 .825 1, .00 44 .56 1SG3489
ATOM 3489 CB ILE 447 96. .663 32. .194 12, .307 1, .00 44 .56 1SG3490
ATOM 3490 CG2 ILE 447 97. .439 33, .472 12, .666 1, .00 44 .56 1SG3491
ATOM 3491 CGI ILE 447 95. .339 32, .043 13, .072 1. .00 44 .56 1SG3492
ATOM 3492 CDl ILE 447 94. .382 33, .213 12 .868 1, .00 44 .56 1S03493
ATOM 3493 C ILE 447 97 .780 3 .327 10 .181 1 .00 44 .56 1SG3494
ATOM 3494 O ILE 447 98. .647 31, .470 10, .348 1, .00 44 .56 1SG3495
ATOM 3495 N SER 448 97. .993 33. .420 9, .426 1, .00 44 .53 1SG3496
ATOM 3496 CA SER 448 99. .246 33, .618 8, .753 1. .00 44 .53 1SG3497
ATOM 3497 CB SER 448 99. .075 33, .853 7 .245 1, .00 44 .53 1SG3498
ATOM 3498 OG SER 448 100. .324 34, .171 6, .655 1, .00 44, .53 1SG3499
ATOM 3499 C SER 448 99. .860 34. .855 9, .322 1, .00 44 .53 1SG3500
ATOM 3500 O SER 448 99. .149 35. .802 9, .654 1. .00 44. .53 1SG3501
ATOM 3501 N THR 449 101. .204 34. .875 9, .474 1, .00 44, .99 1SG3502
ATOM 3502 CA THR 449 101. .790 36. .055 10 .041 1, .00 44 .99 1SG3503
ATOM 3503 CB THR 449 101. .720 36, .075 11, .540 1, .00 44, .99 1SG3504
ATOM 3504 OGl THR 449 102. .130 37. .340 12, .037 1. .00 44. .99 1SG3505
ATOM 3505 CG2 THR 449 102. .632 34. .963 12, .089 1. .00 44, .99 1SG3506
ATOM 3506 C THR 449 103. .236 36, .177 9 .670 1, .00 44, .99 1SG3507
ATOM 3507 O THR 449 103. .857 35. .255 9. .142 1. .00 44, .99 1SG3508
ATOM 3508 N ASP 450 103. .793 37. .369 9. .958 1. .00 45. ,19 1SG3509
ATOM 3509 CA ASP 450 105. .170 37. .692 9. .740 1. .00 45. .19 1SG3510
ATOM 3510 CB ASP 450 105. .345 39. .093 9. .136 1. .00 45, .19 1SG3511
ATOM 3511 CG ASP 450 106. .689 39. .151 8. .439 1. .00 45, .19 1SG3512
ATOM 3512 ODl ASP 450 107. .324 38. .073 8. ,298 1. .00 45. .19 1SG3513
ATOM 3513 OD2 ASP 450 107. .094 40. .272 8. .032 1. ,00 45. .19 1SG3514
ATOM 3514 C ASP 450 105. ,777 37. .697 11. .114 1. .00 45. .19 1SG3515
ATOM 3515 O ASP 450 105. .089 37. .963 12. .099 1. .00 45. .19 1SG3516
ATOM 3516 N LEU 451 107. 083 37. ,381 11. .210 1. .00 42. .91 1SG3517
ATOM 3517 CA LEU 451 107. 792 37. ,226 12. .451 1. 00 42. .91 1SG3518
ATOM 3518 CB LEU 451 108. .558 35. .874 12. .413 1. .00 42. .91 1SG3519 ATOM 3519 CG LEU 451 109.,504 35..456 13..567 1.,00 42..91 1SG3520
ATOM 3520 CD2 LEU 451 110. ,669 36. .433 13. .808 1. ,00 42. .91 1SG3521
ATOM 3521 CDl LEU 451 110. .036 34. .035 13. .319 1. ,00 42. .91 1SG3522
ATOM 3522 C LEU 451 108. .799 38. .323 12. .581 1. .00 42. .91 1SG3523
ATOM 3523 O LEU 451 109. .439 38. .722 11, .610 1. .00 42. .91 1SG3524
ATOM 3524 N LYS 452 108. .963 38. .828 13, .821 1. .00 38. .85 1SG3525
ATOM 3525 CA LYS 452 109. .977 39. .795 14, .116 1. .00 38. .85 1SG3526
ATOM 3526 CB LYS 452 109. .432 41, .144 14, .615 1. .00 38. .85 1SG3527
ATOM 3527 CG LYS 452 110. .532 42 , .164 14. .921 1. .00 38, .85 1SG3528
ATOM 3528 CD LYS 452 110. .013 43. .590 15. .118 1. .00 38, .85 1SG3529
ATOM 3529 CE LYS 452 111. .119 44. .603 15. .422 1. .00 38. .85 1SG3530
ATOM 3530 NZ LYS 452 110. .538 45, .953 15. .594 1. .00 38. .85 1SG3531
ATOM 3531 C LYS 452 110. .758 39, .192 15. .236 1. .00 38. .85 1SG3532
ATOM 3532 O LYS 452 110. .182 38. .630 16. .165 1. .00 38, .85 1SG3533
ATOM 3533 N TYR 453 112. .098 39. .283 15, .169 1. .00 34, .51 1SG3534
ATOM 3534 CA TYR 453 112. .953 38. .703 16 .161 1. .00 34 .51 1SG3535
ATOM 3535 CB TYR 453 114. .093 37, .895 15 .515 1. .00 34 .51 1SG3536
ATOM 3536 CG TYR 453 114. .999 37. .354 16 .564 1. .00 34 .51 1SG3537
ATOM 3537 CDl TYR 453 114. .757 36. .127 17, .132 1. .00 34, .51 1SG3538
ATOM 3538 CD2 TYR 453 116. .097 38. .073 16 .974 1. .00 34 .51 1SG3539
ATOM 3539 CE1 TYR 453 115, .601 35. .629 18 .096 1, .00 34 .51 1SG3540
ATOM 3540 CE2 TYR 453 116, .944 37. .580 17 .938 1. .00 34 .51 1SG3541
ATOM 3541 CZ TYR 453 116. .693 36. .353 18, .501 1. .00 34 .51 1SG3542
ATOM 3542 OH TYR 453 117. .549 35, .830 19 .492 1. .00 34 .51 1SG3543
ATOM 3543 C TYR 453 113. .593 39, .835 16 .891 1. .00 34 .51 1SG3544
ATOM 3544 O TYR 453 114. .269 40, .666 16 .286 1. .00 34 .51 1SG3545
ATOM 3545 N GLU 454 113. .392 39, .902 18 .222 1, .00 29 .43 1SG3546
ATOM 3546 CA GLU 454 114, .002 40. .971 18 .955 1. .00 29 .43 1SG3547
ATOM 3547 CB GLU 454 113, .273 41. .323 20 .267 1. .00 29 .43 1SG3548
ATOM 3548 CG GLU 454 113, .262 40, .198 21 .303 1, .00 29 .43 1SG3549
ATOM 3549 CD GLU 454 112, .510 40, .680 22 .537 1. .00 29 .43 1SG3550
ATOM 3550 OEl GLU 454 112. .068 41. .860 22 .540 1. .00 29 .43 1SG3551
ATOM 3551 OE2 GLU 454 112, .362 39. .871 23 .491 1, .00 29 .43 1SG3552
ATOM 3552 C GLU 454 115, .412 40. .513 19 .304 1, .00 29 .43 1SG3553
ATOM 3553 O GLU 454 116. .377 41. .218 18 .905 1, .00 29 .43 1SG3554
ATOM 3554 OXT GLU 454 115. .543 39. .451 19, .970 1, .00 29 .43 1SG3555
END
TABLE 54 Atomic Coordinates of BPIL 232-4 Molecular Model
ATOM 1 N ILE 1 98 .278 10. .064 17, .565 1, .00 42, .76 ISG 2
ATOM 2 CA ILE 1 97 .375 11. .077 18, .164 1. .00 42, .76 ISG 3
ATOM 3 CB ILE 1 97 .951 11. .576 19 .461 1, .00 42 .76 ISG 4
ATOM 4 CG2 ILE 1 97 .212 12. .872 19 .842 1, .00 42 .76 ISG 5
ATOM 5 CGI ILE 1 97 .912 10. .498 20 .552 1, .00 42, .76 ISG 6
ATOM 6 CDl ILE 1 96 .492 10. .163 21, .005 1. .00 42, .76 ISG 7
ATOM 7 C ILE 1 97 .308 12. .267 17 .273 1, .00 42 .76 ISG 8
ATOM 8 O ILE 1 98 .331 12, .881 16 .977 1, .00 42 .76 ISG 9
ATOM 9 N TYR 2 96 .103 12. .629 16 .805 1. .00 43, .64 ISG 10
ATOM 10 CA TYR 2 96 .005 13. .817 16, .013 1. .00 43. .64 ISG 11
ATOM 11 CB TYR 2 94 .749 13. .889 15 .130 1. .00 43. .64 ISG 12
ATOM 12 CG TYR 2 95 .222 13. .446 13 .789 1. .00 43, .64 ISG 13
ATOM 13 CDl TYR 2 95 .586 12. .145 13, .522 1. .00 43. .64 ISG 14
ATOM 14 CD2 TYR 2 95 .362 14. .394 12, .802 1. .00 43. .64 ISG 15
ATOM 15 CE1 TYR 2 96 .040 11. .794 12 .270 1. .00 43. .64 ISG 16 t-- co en o H CN co ^ ιn vD r- eD cn o ri cN co ^ ιn vD r- co on o ri CN ro ^ ιn vD t^ eD cn o ri CN ro ^ ιn vo ι^ oo cn o H CN co ^ vD i^ co on o H eN ro ri ri H M ( M ( l N Ol M ^^ « n n M n m n n n n * * ^ ^lι ^ ^ <il '. <f <. ι l ιn ιn ιn ln ιn ι ιn ι ^o ^o ^o ιo ^o ^o ιD lD lD U) ^ ^ ^
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ATOM 130 OH TYR 16 113..129 40..143 14..114 1.,00 27..96 ISG 131
ATOM 131 C TYR 16 114. .454 35. .092 10. .644 1. .00 27. .96 ISG 132
ATOM 132 O TYR 16 115. .335 35. .709 11. .242 1. .00 27. .96 ISG 133
ATOM 133 N GLY 17 114. .195 33. .794 10. .890 1. .00 28. .49 ISG 134
ATOM 134 CA GLY 17 114. .902 33. .079 11. .912 1. .00 28. .49 ISG 135
ATOM 135 C GLY 17 116, .356 33 , .065 11. .560 1. .00 28, .49 ISG 136
ATOM 136 O GLY 1 117. .214 33. .157 12. .435 1. .00 28, .49 ISG 137
ATOM 137 N VAL 18 116, .662 32. .926 10. .257 1. .00 29, .07 ISG 138
ATOM 138 CA VAL 18 118, .012 32, .837 9, .776 1, .00 29, .07 ISG 139
ATOM 139 CB VAL 18 118. .070 32. .700 8. .285 1. .00 29. .07 ISG 140
ATOM 140 CGI VAL 18 119. .542 32. .610 7. .856 1, .00 29, .07 ISG 141
ATOM 141 CG2 VAL 18 117. .185 31, .527 7. .851 1. .00 29, .07 ISG 142
ATOM 142 C VAL 18 118. .740 34. .101 10. .083 1. .00 29, .07 ISG 143
ATOM 143 O VAL 18 119, .888 34. .074 10. .522 1. .00 29, .07 ISG 144
ATOM 144 N GLN 19 118, .088 35. .255 9. .846 1, .00 30, .38 ISG 145
ATOM 145 CA GLN 19 118, .753 36. .509 10. .039 1. .00 30 .38 ISG 146
ATOM 146 CB GLN 19 117. .867 37. .711 9, .674 1. .00 30, .38 ISG 147
ATOM 147 CG GLN 19 118. .564 39. .060 9, .854 1, .00 30 .38 ISG 148
ATOM 148 CD GLN 19 119. .546 39. .227 8. .704 1, .00 30 .38 ISG 149
ATOM 149 OEl GLN 19 119, .587 38 , .404 7. .792 1, .00 30 .38 ISG 150
ATOM 150 NE2 GLN 19 120, .354 40. .321 8, .743 1, .00 30 .38 ISG 151
ATOM 151 C GLN 19 119, .110 36. .644 11. .482 1, .00 30 .38 ISG 152
ATOM 152 O GLN 19 120, .225 37. .035 11. .823 1, .00 30, .38 ISG 153
ATOM 153 N ALA 20 118, .163 36 , .312 12. .375 1, .00 29 .43 ISG 154
ATOM 154 CA ALA 20 118, .431 36. .443 13. .775 1, .00 29 .43 ISG 155
ATOM 155 CB ALA 20 117, .218 36. .089 14. .654 1, .00 29, .43 ISG 156
ATOM 156 C ALA 20 119, .534 35, .498 14. .127 1, .00 29 .43 ISG 157
ATOM 157 O ALA 20 120, .452 35, .844 14. .867 1, .00 29 .43 ISG 158
ATOM 158 N GLY 21 119 .471 34, .271 13. .582 1 .00 30 .79 ISG 159
ATOM 159 CA GLY 21 120, .421 33 , .254 13, .926 1, .00 30, .79 ISG 160
ATOM 160 C GLY 21 121 .808 33, .612 13, .490 1, .00 30 .79 ISG 161
ATOM 161 O GLY 21 122 .754 33, .463 14, .259 1 .00 30 .79 ISG 162
ATOM 162 N MET 22 121, .970 34, .111 12 , .252 1, .00 34 .79 ISG 163
ATOM 163 CA MET 22 123, .274 34 , .392 11, .722 1, .00 34 .79 ISG 164
ATOM 164 CB MET 22 123, .187 34, .948 10, .291 1 .00 34 .79 ISG 165
ATOM 165 CG MET 22 124. .532 35. .270 9, .642 1. .00 34. .79 ISG 166
ATOM 166 SD MET 22 124. .384 35. .918 7, .949 1, .00 34 .79 ISG 167
ATOM 167 CE MET 22 123, .639 37. .496 8, .452 1 .00 34 .79 ISG 168
ATOM 168 C MET 22 123 , .922 35. .432 12. .580 1. .00 34. .79 ISG 169
ATOM 169 O MET 22 125, .102 35. .333 12. .914 1, .00 34. .79 ISG 170
ATOM 170 N LYS 23 123 .153 36. .451 12. .988 1, .00 38 .39 ISG 171
ATOM 171 CA LYS 23 123. .743 37. .496 13. .768 1. .00 38. .39 ISG 172
ATOM 172 CB LYS 23 122 , .724 38. .572 14. .180 1, .00 38. .39 ISG 173
ATOM 173 CG LYS 23 122 , .138 39. .344 12. .996 1, .00 38. .39 ISG 174
ATOM 174 CD LYS 23 120, .900 40. .167 13. .357 1, .00 38 .39 ISG 175
ATOM 175 CE LYS 23 120, .311 40. .941 12. .175 1. .00 38. .39 ISG 176
ATOM 176 NZ LYS 23 119, .124 41. .707 12. .614 1. .00 38. .39 ISG 177
ATOM 177 C LYS 23 124, .278 36, .888 15. .023 1, .00 38. .39 ISG 178
ATOM 178 O LYS 23 125. .411 37. .150 15. .421 1. .00 38. .39 ISG 179
ATOM 179 N MET 24 123. .470 36. .031 15. .670 1, .00 46, .17 ISG 180
ATOM 180 CA MET 24 123. .891 35. .414 16. .891 1, .00 46, .17 ISG 181
ATOM 181 CB MET 24 122. .780 34. .612 17. .593 1. .00 46, .17 ISG 182
ATOM 182 CG MET 24 121. .855 35. .466 18. .468 1, .00 46, .17 ISG 183
ATOM 183 SD MET 24 120, .800 36. .656 17. .590 1. .00 46, .17 ISG 184
ATOM 184 CE MET 24 122. .117 37. ,879 17. .329 1. .00 46. .17 ISG 185
ATOM 185 C MET 24 125. .042 34. ,494 16. .634 1. .00 46. .17 ISG 186
ATOM 186 O MET 24 125. .926 34. .349 17. .475 1, .00 46, .17 ISG 187 ATOM 187 N ILE 25 125..043 33..817 15,.474 1..00 50..93 ISG 188
ATOM 188 CA ILE 25 126. .076 32. .872 15 .171 1. .00 50. .93 ISG 189
ATOM 189 CB ILE 25 125. .748 31. .928 14, .036 1. .00 50. .93 ISG 190
ATOM 190 CG2 ILE 25 124. .550 31. .083 14, .496 1. .00 50. .93 ISG 191
ATOM 191 CGI ILE 25 125, .505 32, .640 12 .699 1. .00 50. .93 ISG 192
ATOM 192 CDl ILE 25 126. .754 33, .256 12, .083 1. .00 50. .93 ISG 193
ATOM 193 C ILE 25 127. .403 33 .531 14, .970 1. .00 50. .93 ISG 194
ATOM 194 O ILE 25 128, .432 32, .975 15 .348 1 . 00 50. .93 ISG 195
ATOM 195 N GLU 26 127, .429 34, .741 14, .385 1 .00 54. .19 ISG 196
ATOM 196 CA GLU 26 128. .688 35, .352 14, .069 1. .00 54. .19 ISG 197
ATOM 197 CB GLU 26 128. .537 36. .747 13 .435 1, .00 54. .19 ISG 198
ATOM 198 CG GLU 26 127, .868 37. .775 14, .350 1, .00 54. .19 ISG 199
ATOM 199 CD GLU 26 127. .790 39. .095 13, .597 1, .00 54. .19 ISG 200
ATOM 200 OEl GLU 26 128. .251 39 .137 12 .425 1. .00 54 .19 ISG 201
ATOM 201 OE2 GLU 26 127. .267 40. .080 14 .184 1, .00 54. .19 ISG 202
ATOM 202 C GLU 26 129. .519 35. .506 15, .309 1. .00 54, .19 ISG 203
ATOM 203 O GLU 26 130. .721 35 .247 15 .285 1. .00 54 .19 ISG 204
ATOM 204 N GLN 27 128. .904 35. .907 16 .437 1, .00 58, .57 ISG 205
ATOM 205 CA GLN 27 129. .659 36, .159 17, .634 1. .00 58, .57 ISG 206
ATOM 206 CB GLN 27 128, .778 36 .642 18 .799 1. .00 58 .57 ISG 207
ATOM 207 CG GLN 27 129. .561 36 .919 20 .084 1, .00 58 .57 ISG 208
ATOM 208 CD GLN 27 130, .383 38 .182 19. .871 1, .00 58, .57 ISG 209
ATOM 209 OEl GLN 27 129. .202 37 .868 19 .734 1 .00 58 .57 ISG 210
ATOM 210 NE2 GLN 27 131. .544 37, .593 20. .267 1. .00 58 .57 ISG 211
ATOM 211 C GLN 27 130. .349 34, .907 18. .083 1. .00 58, .57 ISG 212
ATOM 212 O GLN 27 131, .521 34 .939 18, .455 1 .00 58 .57 ISG 213
ATOM 213 N MET 28 129, .642 33 .764 18, .047 1. .00 59 .77 ISG 214
ATOM 214 CA MET 28 130, .197 32, .520 18, .498 1. .00 59, .77 ISG 215
ATOM 215 CB MET 28 129 .187 31 .360 18, .439 1. .00 59 .77 ISG 216
ATOM 216 CG MET 28 128. .013 31 .522 19, .407 1. .00 59, .77 ISG 217
ATOM 217 SD MET 28 126. .801 30, .168 19, .356 1. .00 59, .77 ISG 218
ATOM 218 CE MET 28 127 .913 28 .933 20, .089 1. .00 59 .77 ISG 219
ATOM 219 C MET 28 131. .332 32 .166 17, .608 1. .00 59 .77 ISG 220
ATOM 220 O MET 28 132. .344 31, .624 18, .048 1. .00 59, .77 ISG 221
ATOM 221 N LEU 29 131, .188 32 .458 16 .310 1, .00 65, .99 ISG 222
ATOM 222 CA LEU 29 132. .235 32 .111 15. .415 1, .00 65, .99 ISG 223
ATOM 223 CB LEU 29 131. .891 32 .376 13. .939 1. .00 65, . 99 ISG 224
ATOM 224 CG LEU 29 131, .041 31 .269 13. .282 1. .00 65, .99 ISG 225
ATOM 225 CD2 LEU 29 129. .774 30 .950 14. .084 1. .00 65. .99 ISG 226
ATOM 226 CDl LEU 29 131. .888 30, .013 13. .029 1. .00 65. .99 ISG 227
ATOM 227 C LEU 29 133. .478 32, .863 15. .761 1. .00 65. .99 ISG 228
ATOM 228 O LEU 29 134. .562 32, .289 15. .758 1. .00 65. .99 ISG 229
ATOM 229 N LYS 30 133. .350 34, .146 16. .134 1. .00 69, .43 ISG 230
ATOM 230 CA LYS 30 134. .478 35, .007 16. .375 1. .00 69, .43 ISG 231
ATOM 231 CB LYS 30 134. .034 36, .393 16. .871 1. .00 69. .43 ISG 232
ATOM 232 CG LYS 30 135. .118 37, .471 16. .829 1. .00 69. .43 ISG 233
ATOM 233 CD LYS 30 135. .371 38, .025 15. .428 1. .00 69, .43 ISG 234
ATOM 234 CE LYS 30 136. .231 39, .289 15. .426 1. .00 69. .43 ISG 235
ATOM 235 NZ LYS 30 136. .064 40, .005 14. .143 1. .00 69. .43 ISG 236
ATOM 236 C LYS 30 135. .354 34. .427 17. .452 1. ,00 69, .43 ISG 237
ATOM 237 O LYS 30 136. .571 34. .601 17, .420 1. ,00 69. ,43 ISG 238
ATOM 238 N GLU 31 134. .751 33. .744 18. .443 1. ,00 72. ,80 ISG 239
ATOM 239 CA GLU 31 135. .413 33. .235 19. .618 1. ,00 72. .80 ISG 240
ATOM 240 CB GLU 31 134. .452 32. .798 20. .741 1. ,00 72. ,80 ISG 241
ATOM 241 CG GLU 31 133. ,661 31. .526 20. .445 1. ,00 72. ,80 ISG 242
ATOM 242 CD GLU 31 132. ,773 31. .239 21. .647 1. ,00 72. .80 ISG 243
ATOM 243 OEl GLU 31 132. ,827 32. .031 22. .625 1. ,00 72. 80 ISG 244 ATOM 244 OE2 GLU 31 132..026 30..225 21..603 1..00 72..80 ISG 245
ATOM 245 C GLU 31 136. .358 32. .082 19. .381 1. .00 72. .80 ISG 246
ATOM 246 O GLU 31 137. .216 31, .837 20, .223 1. .00 72. .80 ISG 247
ATOM 247 N LYS 32 136. .227 31. .311 18. .284 1. .00 76. .70 ISG 248
ATOM 248 CA LYS 32 136. .994 30. .091 18. .147 1. .00 76. .70 ISG 249
ATOM 249 CB LYS 32 136. .796 29. .352 16, .809 1. .00 76. .70 ISG 250
ATOM 250 CG LYS 32 137. .930 29. .554 15, .800 1. .00 76. .70 ISG 251
ATOM 251 CD LYS 32 138. .230 31, .002 15, .424 1. .00 76, .70 ISG 252
ATOM 252 CE LYS 32 139, .503 31. .140 14. .586 1. .00 76, .70 ISG 253
ATOM 253 NZ LYS 32 139. .272 30. .614 13. .223 1. .00 76. .70 ISG 254
ATOM 254 C LYS 32 138. .463 30. .343 18, .291 1. .00 76, .70 ISG 255
ATOM 255 0 LYS 32 138. .961 31. .437 18. .033 1. .00 76. .70 ISG 256
ATOM 256 N LYS 33 139, .208 29. .316 18. .752 1, .00 74, .13 ISG 257
ATOM 257 CA LYS 33 140, .615 29. .519 18, .926 1. .00 74, .13 ISG 258
ATOM 258 CB LYS 33 141. .053 29. .441 20. .397 1. .00 74. .13 ISG 259
ATOM 259 CG LYS 33 142, .464 29, .973 20, .639 1. .00 74, .13 ISG 260
ATOM 260 CD LYS 33 142 , .595 31. .481 20. .420 1, .00 74, .13 ISG 261
ATOM 261 CE LYS 33 141, .875 32. .318 21. .479 1. .00 74 .13 ISG 262
ATOM 262 NZ LYS 33 140. .412 32, .117 21, .374 1. .00 74, .13 ISG 263
ATOM 263 C LYS 33 141. .370 28 , .470 18. .167 1. .00 74, .13 ISG 264
ATOM 264 0 LYS 33 141. .095 27. .276 18. .279 1. .00 74, .13 ISG 265
ATOM 265 N LEU 34 142, .352 28. .902 17. .351 1, .00 70, .72 ISG 266
ATOM 266 CA LEU 34 143, .157 27, .947 16 .649 1 .00 70 .72 ISG 267
ATOM 267 CB LEU 34 143, .137 28, .057 15. .110 1, .00 70, .72 ISG 268
ATOM 268 CG LEU 34 143 , .680 29. .356 14. .495 1. .00 70, .72 ISG 269
ATOM 269 CD2 LEU 34 143, .278 29. .447 13 .013 1. .00 70, .72 ISG 270
ATOM 270 CDl LEU 34 145, .196 29. .511 14. .705 1, .00 70, .72 ISG 271
ATOM 271 C LEU 34 144, .559 28 .043 17 .175 1, .00 70 .72 ISG 272
ATOM 272 0 LEU 34 144, .999 29, .075 17, .680 1, .00 70, .72 ISG 273
ATOM 273 N PRO 35 145, .250 26. .943 17, .074 1, .00 62, .85 ISG 274
ATOM 274 CA PRO 35 146. .590 26. .830 17, .594 1, .00 62 .85 ISG 275
ATOM 275 CD PRO 35 144, .574 25, .659 17, .043 1, .00 62, .85 ISG 276
ATOM 276 CB PRO 35 146 .865 25, .330 17 .736 1, .00 62 .85 ISG 277
ATOM 277 CG PRO 35 145, .719 24, .641 16, .972 1, .00 62, .85 ISG 278
ATOM 278 C PRO 35 147. .628 27. .550 16, .791 1. .00 62, .85 ISG 279
ATOM 279 0 PRO 35 147. .334 28, .025 15, .697 1, .00 62 .85 ISG 280
ATOM 280 N ASP 36 148, .849 27. .679 17, .344 1, .00 52, .59 ISG 281
ATOM 281 CA ASP 36 149, .908 28. .352 16 .649 1, .00 52 .59 ISG 282
ATOM 282 CB ASP 36 150, .668 29. .363 17, .524 1, .00 52, .59 ISG 283
ATOM 283 CG ASP 36 151, .261 28. .620 18. .710 1. .00 52 , .59 ISG 284
ATOM 284 ODl ASP 36 150, .508 27. .850 19. .362 1. .00 52, .59 ISG 285
ATOM 285 OD2 ASP 36 152, .478 28. .810 18. .976 1. .00 52, .59 ISG 286
ATOM 286 C ASP 36 150, .881 27, .333 16, .136 1. .00 52, .59 ISG 287
ATOM 287 O ASP 36 151, .149 26, .324 16, .786 1. .00 52, .59 ISG 288
ATOM 288 N LEU 37 151. .426 27. .564 14. .923 1. .00 44. .17 ISG 289
ATOM 289 CA LEU 37 152, .345 26. .612 14. .369 1. .00 44, .17 ISG 290
ATOM 290 CB LEU 37 151, .922 26. .089 12, .986 1. .00 44. .17 ISG 291
ATOM 291 CG LEU 37 150, .597 25, .302 13, .022 1. .00 44, .17 ISG 292
ATOM 292 CD2 LEU 37 150, .637 24. .193 14. .085 1. .00 44. .17 ISG 293
ATOM 293 CDl LEU 37 150, .211 24. .780 11. .629 1. .00 44. .17 ISG 294
ATOM 294 C LEU 37 153, .693 27. .248 14. .223 1. .00 44. .17 ISG 295
ATOM 295 0 LEU 37 153. .830 28. .345 13. .682 1. .00 44. .17 ISG 296
ATOM 296 N SER 38 154. .741 26. .552 14. .706 1. .00 39, .47 ISG 297
ATOM 297 CA SER 38 156. .065 27. .093 14. .615 1. .00 39. .47 ISG 298
ATOM 298 CB SER 38 156. .710 27. .340 15. .988 1. ,00 39. .47 ISG 299
ATOM 299 OG SER 38 155. .947 28. .293 16. .714 1. .00 39. .47 ISG 300
ATOM 300 C SER 38 156. .919 26. .103 13. .883 1. ,00 39. ,47 ISG 301 ATOM 301 O SER 38 156..763 24..894 14..045 1..00 39..47 ISG 302
ATOM 302 N GLY 39 157. .854 26. .603 13. .048 1. .00 38. .73 ISG 303
ATOM 303 CA GLY 39 158. .720 25. .740 12. .292 1. ,00 38. .73 ISG 304
ATOM 304 C GLY 39 159. .819 26. .580 11. ,701 1. ,00 38. .73 ISG 305
ATOM 305 O GLY 39 159. .827 27. .805 11. ,843 1. ,00 38. ,73 ISG 306
ATOM 306 N SER 40 160. .776 25. .927 11. .004 1. ,00 41. .19 ISG 307
ATOM 307 CA SER 40 161. .906 26. .614 10. .430 1. ,00 41. .19 ISG 308
ATOM 308 CB SER 40 163. .255 26. .003 10. .847 1. .00 41. .19 ISG 309
ATOM 309 OG SER 40 164. .330 26. .720 10. .262 1. .00 41. .19 ISG 310
ATOM 310 C SER 40 161. .810 26. .503 8. .937 1. .00 41. .19 ISG 311
ATOM 311 O SER 40 161. .097 25. .642 8. ,425 1. .00 41. .19 ISG 312
ATOM 312 N GLU 41 162 .501 27, .396 8, .189 1. .00 42. .80 ISG 313
ATOM 313 CA GLU 41 162, .420 27, .315 6, .755 1, .00 42, .80 ISG 314
ATOM 314 CB GLU 41 161 .163 27, .986 6. .175 1. .00 42. .80 ISG 315
ATOM 315 CG GLU 41 159 .858 27, .298 6, .581 1. .00 42. .80 ISG 316
ATOM 316 CD GLU 41 159, .792 25, .949 5, .879 1, .00 42. .80 ISG 317
ATOM 317 OEl GLU 41 160, .751 25, .624 5. .130 1. .00 42, .80 ISG 318
ATOM 318 OE2 GLU 41 158, .780 25, .226 6. .084 1. .00 42. .80 ISG 319
ATOM 319 C GLU 41 163 .597 28, .006 6, .150 1, .00 42, .80 ISG 320
ATOM 320 O GLU 41 164 .311 28, .752 6, .817 1, .00 42, .80 ISG 321
ATOM 321 N SER 42 163, .849 27, .726 4. .854 1. .00 41, .85 ISG 322
ATOM 322 CA SER 42 164 .894 28, .395 4. .142 1. .00 41. .85 ISG 323
ATOM 323 CB SER 42 166, .167 27, .548 3, .984 1, .00 41, .85 ISG 324
ATOM 324 OG SER 42 165 .895 26, .401 3. .191 1. .00 41, .85 ISG 325
ATOM 325 C SER 42 164 .371 28, .668 2. .767 1. .00 41, .85 ISG 326
ATOM 326 O SER 42 163 .973 27, .753 2, .048 1, .00 41 .85 ISG 327
ATOM 327 N LEU 43 164 .348 29, .953 2. .370 1. .00 41, .07 ISG 328
ATOM 328 CA LEU 43 163 .921 30, .311 1. .051 1. .00 41, .07 ISG 329
ATOM 329 CB LEU 43 162 .740 31, .303 1. .054 1. .00 41, .07 ISG 330
ATOM 330 CG LEU 43 162 .061 31. .537 -0. .313 1. .00 41, .07 ISG 331
ATOM 331 CD2 LEU 43 163 .060 31. .925 -1. .411 1. .00 41, .07 ISG 332
ATOM 332 CDl LEU 43 160 .909 32. .545 -0. .183 1. .00 41, .07 ISG 333
ATOM 333 C LEU 43 165 .120 30. .989 0. .476 1. .00 41, .07 ISG 334
ATOM 334 O LEU 43 165, .721 31. .835 1. .135 1, .00 41, .07 ISG 335
ATOM 335 N GLU 44 165, .500 30. .649 -0, .769 1. .00 40, .00 ISG 336
ATOM 336 CA GLU 44 166, .723 31. .186 -1. .293 1. .00 40, .00 ISG 337
ATOM 337 CB GLU 44 167, .003 30. .729 -2. .735 1. .00 40, .00 ISG 338
ATOM 338 CG GLU 44 167, .283 29, .230 -2 , .853 1, .00 40, .00 ISG 339
ATOM 339 CD GLU 44 167, .541 28, .912 -4. .319 1. .00 40. .00 ISG 340
ATOM 340 OEl GLU 44 167. .493 29, .860 -5. .147 1. .00 40. .00 ISG 341
ATOM 341 OE2 GLU 44 167. .790 27, .716 -4. .630 1. .00 40. .00 ISG 342
ATOM 342 C GLU 44 166. .639 32, .677 -1. .300 1. .00 40, .00 ISG 343
ATOM 343 O GLU 44 167. .555 33 , .358 -0, .843 1. .00 40, .00 ISG 344
ATOM 344 N PHE 45 165. .532 33, .226 -1. .824 1. .00 41, .79 ISG 345
ATOM 345 CA PHE 45 165. .393 34 , .649 -1. .863 1. .00 41. .79 ISG 346
ATOM 346 CB PHE 45 164, .199 35, .101 -2, .720 1. .00 41. .79 ISG 347
ATOM 347 CG PHE 45 164, .501 34, .729 -4, .131 1. .00 41. .79 ISG 348
ATOM 348 CDl PHE 45 165. .281 35, .546 -4. .917 1. .00 41. .79 ISG 349
ATOM 349 CD2 PHE 45 164. .005 33. .564 -4. .668 1. .00 41. .79 ISG 350
ATOM 350 CE1 PHE 45 165. .562 35. .205 -6 , .219 1. .00 41. .79 ISG 351
ATOM 351 CE2 PHE 45 164. .282 33. .218 -5. .970 1. .00 41. .79 ISG 352
ATOM 352 CZ PHE 45 165. .063 34. .040 -6. .747 1. .00 41. .79 ISG 353
ATOM 353 C PHE 45 165, .193 35. .211 -0. .487 1. .00 41. .79 ISG 354
ATOM 354 O PHE 45 165, .875 36. .156 -0. .093 1. .00 41. .79 ISG 355
ATOM 355 N LEU 46 164. .242 34. .639 0. .283 1. ,00 43. ,86 ISG 356
ATOM 356 CA LEU 46 163. .877 35. .232 1. .540 1. ,00 43. .86 ISG 357
ATOM 357 CB LEU 46 162. .619 34. .584 2 , .147 1. .00 43. .86 ISG 358 ATOM 358 CG LEU 46 162.,191 35..196 3..494 1.00 43.,86 ISG 359
ATOM 359 CD2 LEU 46 161. ,063 34. ,378 4. .143 1. ,00 43. ,86 ISG 360
ATOM 360 CDl LEU 46 161. .829 36. ,682 3. .340 1. .00 43. ,86 ISG 361
ATOM 361 C LEU 46 164. .965 35. .168 2. .569 1. ,00 43. ,86 ISG 362
ATOM 362 O LEU 46 165. .401 36. .217 3. .037 1. ,00 43. ,86 ISG 363
ATOM 363 N LYS 47 165. .439 33. .944 2. .911 1. .00 44. .66 ISG 364
ATOM 364 CA LYS 47 166. .455 33. .696 3. .912 1. .00 44. .66 ISG 365
ATOM 365 CB LYS 47 166. .632 34. .788 4. .990 1. .00 44. .66 ISG 366
ATOM 366 CG LYS 47 167. .925 34. .672 5. .803 1. .00 44. .66 ISG 367
ATOM 367 CD LYS 47 169. .188 34. .961 4. .990 1. .00 44. .66 ISG 368
ATOM 368 CE LYS 47 169. .418 36. .450 4. .724 1, .00 44. .66 ISG 369
ATOM 369 NZ LYS 47 169. ,872 37, .121 5. .963 1. .00 44, .66 ISG 370
ATOM 370 C LYS 47 166. .037 32. .461 4. .652 1. .00 44. .66 ISG 371
ATOM 371 O LYS 47 165. .058 31. .810 4. .290 1. .00 44. .66 ISG 372
ATOM 372 N VAL 48 166. .790 32. .091 5. .710 1. .00 41. .62 ISG 373
ATOM 373 CA VAL 48 166. .421 30. .954 6. .503 1. .00 41. .62 ISG 374
ATOM 374 CB VAL 48 167. .551 29. .993 6. .739 1. .00 41. .62 ISG 375
ATOM 375 CGI VAL 48 167. .981 29, .407 5, .384 1. .00 41, .62 ISG 376
ATOM 376 CG2 VAL 48 168. .682 30, .725 7. .481 1, .00 41, .62 ISG 377
ATOM 377 C VAL 48 165, .980 31, .473 7. .835 1, .00 41, .62 ISG 378
ATOM 378 O VAL 48 166, .655 32, .304 8. .440 1. .00 41, .62 ISG 379
ATOM 379 N ASP 49 164, .806 31, .012 8 .315 1. .00 36, .29 ISG 380
ATOM 380 CA ASP 49 164, .321 31, .474 9 .583 1, .00 36, .29 ISG 381
ATOM 381 CB ASP 49 163, .320 32 .638 9 .475 1 .00 36 .29 ISG 382
ATOM 382 CG ASP 49 164 .066 33 .891 9 .042 1 .00 36 .29 ISG 383
ATOM 383 ODl ASP 49 165 .214 34 .094 9 .521 1 .00 36 .29 ISG 384
ATOM 384 OD2 ASP 49 163 .499 34 .662 8 .224 1 .00 36 .29 ISG 385
ATOM 385 C ASP 49 163, .589 30, .357 10. .260 1, .00 36, .29 ISG 386
ATOM 386 O ASP 49 162, .822 29, .630 9. .633 1, .00 36. .29 ISG 387
ATOM 387 N TYR 50 163, .840 30, .188 11 .572 1, .00 34. .89 ISG 388
ATOM 388 CA TYR 50 163, .133 29, .247 12. .394 1, .00 34. .89 ISG 389
ATOM 389 CB TYR 50 163, .998 28, .092 12 .929 1, .00 34 .89 ISG 390
ATOM 390 CG TYR 50 163, .183 27, .349 13 .933 1, .00 34 .89 ISG 391
ATOM 391 CDl TYR 50 162, .172 26, .500 13 .543 1. .00 34 .89 ISG 392
ATOM 392 CD2 TYR 50 163 .441 27, .496 15 .276 1 .00 34 .89 ISG 393
ATOM 393 CE1 TYR 50 161, .427 25 .819 14 .477 1 .00 34 .89 ISG 394
ATOM 394 CE2 TYR 50 162 .700 26 .818 16 .216 1 .00 34 .89 ISG 395
ATOM 395 CZ TYR 50 161 .690 25 .978 15 .816 1 .00 34 .89 ISG 396
ATOM 396 OH TYR 50 160 .927 25 .280 16 .777 1 .00 34 .89 ISG 397
ATOM 397 C TYR 50 162 .692 30 .055 13 .562 1 .00 34 .89 ISG 398
ATOM 398 O TYR 50 163 .354 31 .035 13 .895 1 .00 34 .89 ISG 399
ATOM 399 N VAL 51 161 .547 29 .696 14 .184 1 .00 34 .15 ISG 400
ATOM 400 CA VAL 51 161, .003 30, .476 15, .264 1, .00 34. .15 ISG 401
ATOM 401 CB VAL 51 162, .002 30, .997 16, .262 1, .00 34, .15 ISG 402
ATOM 402 CGI VAL 51 161, .269 31, .932 17, .239 1, .00 34, .15 ISG 403
ATOM 403 CG2 VAL 51 162, .685 29, .803 16 .949 1, .00 34, .15 ISG 404
ATOM 404 C VAL 51 160, .328 31, .632 14 .609 1, .00 34, .15 ISG 405
ATOM 405 O VAL 51 159, .137 31, .874 14 .801 1, .00 34, .15 ISG 406
ATOM 406 N ASN 52 161, .102 32, .364 13 .788 1 .00 38, .67 ISG 407
ATOM 407 CA ASN 52 160, .600 33, .466 13 .038 1, .00 38, .67 ISG 408
ATOM 408 CB ASN 52 161, .651 34, .080 12 .099 1 .00 38, .67 ISG 409
ATOM 409 CG ASN 52 161, .065 35, .348 11 .494 1 .00 38 .67 ISG 410
ATOM 410 ODl ASN 52 159, .968 35, .339 10 .938 1 .00 38, .67 ISG 411
ATOM 411 ND2 ASN 52 161 .816 36, .476 11 .611 1 .00 38, .67 ISG 412
ATOM 412 C ASN 52 159, .512 32, .890 12 .203 1 .00 38, .67 ISG 413
ATOM 413 O ASN 52 158 .495 33, .540 11 .965 1 .00 38 .67 ISG 414
ATOM 414 N TYR 53 159. .680 31, .632 11 .746 1 .00 45, .55 ISG 415 ATOM 415 CA TYR 53 158..585 31..110 11.005 1.00 45.,55 ISG 416
ATOM 416 CB TYR 53 158. .950 29. ,931 10. .085 1. .00 45. ,55 ISG 417
ATOM 417 CG TYR 53 157. .684 29. .407 9. ,493 1. .00 45. ,55 ISG 418
ATOM 418 CDl TYR 53 156. .966 28. .427 10. ,140 1. .00 45. .55 ISG 419
ATOM 419 CD2 TYR 53 157. ,208 29. .894 8. .299 1. ,00 45. .55 ISG 420
ATOM 420 CE1 TYR 53 155. ,797 27. .935 9. ,610 1. .00 45. .55 ISG 421
ATOM 421 CE2 TYR 53 156. ,039 29. .406 7. .763 1. .00 45. .55 ISG 422
ATOM 422 CZ TYR 53 155. .332 28. .425 8. .416 1. .00 45. .55 ISG 423
ATOM 423 OH TYR 53 154. ,133 27. .925 7. .865 1. .00 45. .55 ISG 424
ATOM 424 C TYR 53 157. .659 30. .607 12. .043 1. .00 45. .55 ISG 425
ATOM 425 O TYR 53 157. 771 29. .486 12. .535 1. .00 45. ,55 ISG 426
ATOM 426 N ASN 54 156. .743 31. .491 12. .457 1. .00 47. .49 ISG 427
ATOM 427 CA ASN 54 155. ,784 31. .079 13. .416 1. .00 47. .49 ISG 428
ATOM 428 CB ASN 54 156. .176 31. .407 14. .869 1. .00 47. .49 ISG 429
ATOM 429 CG ASN 54 156. .309 32. ,917 15. .010 1. .00 47. .49 ISG 430
ATOM 430 ODl ASN 54 156. ,941 33. .577 14. .187 1. ,00 47. .49 ISG 431
ATOM 431 ND2 ASN 54 155, ,690 33. .484 16. .080 1. .00 47. .49 ISG 432
ATOM 432 C ASN 54 154. .539 31. .813 13. .096 1. .00 47. .49 ISG 433
ATOM 433 O ASN 54 154. .542 33. .031 12. .915 1. .00 47, .49 ISG 434
ATOM 434 N PHE 55 153. .438 31. .065 12. .964 1. .00 51, .48 ISG 435
ATOM 435 CA PHE 55 152. .183 31. .715 12. .804 1. .00 51 .48 ISG 436
ATOM 436 CB PHE 55 151. .295 31, .084 11, .718 1. .00 51, .48 ISG 437
ATOM 437 CG PHE 55 151, ,937 31, .375 10. .403 1. .00 51 .48 ISG 438
ATOM 438 CDl PHE 55 151. .661 32, .545 9. .734 1. .00 51, .48 ISG 439
ATOM 439 CD2 PHE 55 152. .820 30, .483 9. .838 1. .00 51 .48 ISG 440
ATOM 440 CE1 PHE 55 152. .251 32, .819 8. .522 1, .00 51, .48 ISG 441
ATOM 441 CE2 PHE 55 153. .413 30, .751 8. .626 1 .00 51 .48 ISG 442
ATOM 442 CZ PHE 55 153. .129 31 .921 7 .965 1. .00 51 .48 ISG 443
ATOM 443 C PHE 55 151, .540 31, .500 14. .124 1 .00 51 .48 ISG 444
ATOM 444 O PHE 55 151. .302 30 .360 14 .521 1 .00 51 .48 ISG 445
ATOM 445 N SER 56 151. .278 32 .594 14 .859 1 .00 54 .08 ISG 446
ATOM 446 CA SER 56 150. .729 32 .424 16 .167 1 .00 5 .08 ISG 447
ATOM 447 CB SER 56 151. .797 32 .348 17 .273 1, .00 54 .08 ISG 448
ATOM 448 OG SER 56 152. .663 31 .246 17 .046 1 .00 54 .08 ISG 449
ATOM 449 C SER 56 149. .895 33 .620 16 .456 1, .00 54 .08 ISG 450
ATOM 450 O SER 56 149, .871 34 .573 15 .679 1 .00 54 .08 ISG 451
ATOM 451 N ASN 57 149 .171 33 .562 17 .591 1 .00 58 .29 ISG 452
ATOM 452 CA ASN 57 148, .318 34 .618 18 .044 1 .00 58 .29 ISG 453
ATOM 453 CB ASN 57 149 .055 35 .831 18 .657 1 .00 58 .29 ISG 454
ATOM 454 CG ASN 57 149, .942 36 .504 17 .619 1 .00 58 .29 ISG 455
ATOM 455 ODl ASN 57 149 .536 37 .455 16 .952 1 .00 58 .29 ISG 456
ATOM 456 ND2 ASN 57 151, .201 36 .007 17 .486 1 .00 58 .29 ISG 457
ATOM 457 C ASN 57 147 .467 35 .054 16 .903 1 .00 58 .29 ISG 458
ATOM 458 O ASN 57 147, .324 36 .247 16 .640 1 .00 58 .29 ISG 459
ATOM 459 N ILE 58 146 .853 34 .088 16 .193 1 .00 65, .55 ISG 460
ATOM 460 CA ILE 58 146 .053 34 .518 15 .096 1 .00 65 .55 ISG 461
ATOM 461 CB ILE 58 146 .261 33 .748 13 .814 1 .00 65 .55 ISG 462
ATOM 462 CG2 ILE 58 147 .748 33 .885 13 .448 1 .00 65 .55 ISG 463
ATOM 463 CGI ILE 58 145, .786 32 .289 13 .904 1 .00 65 .55 ISG 464
ATOM 464 CDl ILE 58 144 .280 32 .130 13 .702 1 .00 65 .55 ISG 465
ATOM 465 C ILE 58 144, .648 34 .388 15 .538 1 .00 65 .55 ISG 466
ATOM 466 O ILE 58 144 .255 33 .392 16 .140 1 .00 65 .55 ISG 467
ATOM 467 N LYS 59 143, .854 35 .434 15 .289 1 .00 69 .37 ISG 468
ATOM 468 CA LYS 59 142 .505 35 .366 15 .729 1 .00 69 .37 ISG 469
ATOM 469 CB LYS 59 142, .128 36 .471 16 .730 1 .00 69 .37 ISG 470
ATOM 470 CG LYS 59 142 .849 36 .352 18 .074 1 .00 69 .37 ISG 471
ATOM 471 CD LYS 59 142. .728 37, .603 18 .946 1 .00 69, .37 ISG 472 ATOM 472 CE LYS 59 141..329 37..807 19..533 1..00 69..37 ISG 473
ATOM 473 NZ LYS 59 141. .302 39. .033 20. .361 1. ,00 69. .37 ISG 474
ATOM 474 C LYS 59 141. .666 35. .549 14. .525 1. ,00 69. .37 ISG 475
ATOM 475 O LYS 59 142. .150 35. .948 13, .467 1. .00 69. .37 ISG 476
ATOM 476 N ILE 60 140. .376 35. .211 14, .644 1. .00 81. .02 ISG 477
ATOM 477 CA ILE 60 139. .551 35. .493 13. .527 1. .00 81. .02 ISG 478
ATOM 478 CB ILE 60 138. .119 35. .076 13, .692 1. .00 81. .02 ISG 479
ATOM 479 CG2 ILE 60 137. .297 35. .664 12. .535 1. ,00 81. .02 ISG 480
ATOM 480 CGI ILE 60 138. .015 33. .553 13. .786 1. .00 81, .02 ISG 481
ATOM 481 CDl ILE 60 136. .604 33. .087 14. .119 1. .00 81, .02 ISG 482
ATOM 482 C ILE 60 139. .583 36, .964 13. .457 1. .00 81, .02 ISG 483
ATOM 483 O ILE 60 139. .275 37. .642 14. .438 1. .00 81. .02 ISG 484
ATOM 484 N SER 61 140. .018 37. .480 12. .297 1. .00 87. .12 ISG 485
ATOM 485 CA SER 61 140. .156 38. .895 12. .177 1. ,00 87. .12 ISG 486
ATOM 486 CB SER 61 140. .831 39, .327 10. .861 1. .00 87, .12 ISG 487
ATOM 487 OG SER 61 140, .051 38, .929 9. .742 1. .00 87, .12 ISG 488
ATOM 488 C SER 61 138, .805 39, .494 12, .233 1. .00 87, .12 ISG 489
ATOM 489 O SER 61 138. .514 40, .354 13, .061 1. .00 87, .12 ISG 490
ATOM 490 N ALA 62 137. .928 39, .020 11, .342 1. .00 92, .07 ISG 491
ATOM 491 CA ALA 62 136, .603 39. .533 11, .324 1. .00 92 .07 ISG 492
ATOM 492 CB ALA 62 136, .402 40 .679 10 .319 1, .00 92 .07 ISG 493
ATOM 493 C ALA 62 135, .799 38, .396 10 .855 1, .00 92 .07 ISG 494
ATOM 494 O ALA 62 136, .312 37, .541 10, .136 1. .00 92, .07 ISG 495
ATOM 495 N PHE 63 134. .535 38 , .326 11, .291 1. .00 97, .07 ISG 496
ATOM 496 CA PHE 63 133. .743 37. .239 10, .826 1. .00 97, .07 ISG 497
ATOM 497 CB PHE 63 133. .313 36 .323 11 .983 1. .00 97 .07 ISG 498
ATOM 498 CG PHE 63 132. .692 34. .965 11 .329 1. .00 97 .07 ISG 499
ATOM 499 CDl PHE 63 131. .497 34. .686 10, .672 1. .00 97, .07 ISG 500
ATOM 500 CD2 PHE 63 132. .735 33. .570 11, .001 1. .00 97, .07 ISG 501
ATOM 501 CE1 PHE 63 131. .880 33. .324 10, .508 1. .00 97, .07 ISG 502
ATOM 502 CE2 PHE 63 131. .792 34. .505 10, .769 1. .00 97, .07 ISG 503
ATOM 503 CZ PHE 63 132, .936 33. .833 11 .161 1, .00 97, .07 ISG 504
ATOM 504 C PHE 63 132, .499 37. .865 10 .284 1 , .00 97 .07 ISG 505
ATOM 505 O PHE 63 131, .521 38, .040 11 .007 1. .00 97, .07 ISG 506
ATOM 506 N SER 64 132. .467 38, .189 8, .981 1. .00 82, .79 ISG 507
ATOM 507 CA SER 64 131. .284 38, .859 8, .538 1. .00 82, .79 ISG 508
ATOM 508 CB SER 64 131. .566 40, .118 7, .700 1. .00 82 .79 ISG 509
ATOM 509 OG SER 64 132. .221 39, .762 6 .492 1. .00 82, .79 ISG 510
ATOM 510 C SER 64 130, .500 37, .927 7 .683 1. .00 82, .79 ISG 511
ATOM 511 O SER 64 131. .020 37, .370 6, .718 1. .00 82, .79 ISG 512
ATOM 512 N PHE 65 129. .221 37, .710 8, .046 1. .00 70, .77 ISG 513
ATOM 513 CA PHE 65 128. .377 36. .924 7, .195 1. .00 70. .77 ISG 514
ATOM 514 CB PHE 65 127, .453 35. .906 7 .891 1. .00 70. .77 ISG 515
ATOM 515 CG PHE 65 128, .141 34. .674 8 .369 1. .00 70, .77 ISG 516
ATOM 516 CDl PHE 65 128. .585 33. .734 7, .469 1. .00 70, .77 ISG 517
ATOM 517 CD2 PHE 65 128. .337 34. .451 9, .710 1. .00 70, .77 ISG 518
ATOM 518 CE1 PHE 65 129. .213 32. .586 7. .888 1. ,00 70. .77 ISG 519
ATOM 519 CE2 PHE 65 128. .961 33. .302 10, .134 1. ,00 70. .77 ISG 520
ATOM 520 CZ PHE 65 129, .400 32. .366 9 .229 1. .00 70. .77 ISG 521
ATOM 521 C PHE 65 127. .405 37. .881 6, .579 1. .00 70. .77 ISG 522
ATOM 522 O PHE 65 126. .359 38. .164 7, .162 1. .00 70. .77 ISG 523
ATOM 523 N PRO 66 127. .722 38. .397 5. .427 1. ,00 55. .70 ISG 524
ATOM 524 CA PRO 66 126. .881 39. .326 4 , .724 1. ,00 55. .70 ISG 525
ATOM 525 CD PRO 66 128. .761 37. .835 4, .580 1. .00 55. .70 ISG 526
ATOM 526 CB PRO 66 127. .645 39. .667 3, .447 1. .00 55. .70 ISG 527
ATOM 527 CG PRO 66 128. .464 38. .390 3, .176 1. .00 55. .70 ISG 528
ATOM 528 C PRO 66 125. .521 38. .778 4. .403 1. .00 55. .70 ISG 529 > > > > | > > > > | > > > > > > > ' ' > > > | > > > > > > > > > > > > > > > > > > > > > > > > > > H H ^ H ^ H H H ι-_ H ι-3 H H H H H β H ι-3 H H H H ^ H H H H H H H H H ι-3 H H ι i-- H >-3 H ι-- ι-a H H H H H H ι-3 '-3 H H P P P P d d P P P P P O P P P P P P O P P P P P P P P O O P P P P O P P P P P P P P P P O O P P P P P P P P P P P 2 2 2 2 2 2 2 2 2 3 3 3 3 3 2 2 2 2 3 3 3 3 3 2 2 3 3 3 3 3 3 3 2 2 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 2 2 2 3 3 3 2 2
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ATOM 700 OGl THR 91 127..766 28,.670 6,.766 1.,00130,.78 ISG 701
ATOM 701 CG2 THR 91 128, .120 29. .253 9, .095 1. ,00130. .78 ISG 702
ATOM 702 C THR 91 129, .728 26. .746 6. .774 1. .00130. .78 ISG 703
ATOM 703 O THR 91 130, .083 27. .162 5. .673 1. .00130. .78 ISG 704
ATOM 704 N ASP 92 129, .381 25. .443 7. .022 1. ,00108. .57 ISG 705
ATOM 705 CA ASP 92 129, .461 24. .356 6. .061 1. ,00108. .57 ISG 706
ATOM 706 CB ASP 92 128, .344 24. .380 5, .005 1. .00108. .57 ISG 707
ATOM 707 CG ASP 92 128, .482 23. .133 4. .142 1. .00108. .57 ISG 708
ATOM 708 ODl ASP 92 129, .463 22, .371 4. .354 1. .00108, .57 ISG 709
ATOM 709 OD2 ASP 92 127, .608 22, .927 3, .258 1. ,00108, .57 ISG 710
ATOM 710 C ASP 92 130, .755 24 , .563 5, .387 1. .00108. .57 ISG 711
ATOM 711 O ASP 92 130, .846 24 , .708 4. .172 1. .00108 , .57 ISG 712
ATOM 712 N TRP 93 131 .791 24 .570 6 .216 1, .00 85 .71 ISG 713
ATOM 713 CA TRP 93 133 .033 25, .141 5 .878 1. .00 85 .71 ISG 714
ATOM 714 CB TRP 93 133 .971 25 .156 7 .086 1. .00 85 .71 ISG 715
ATOM 715 CG TRP 93 133 .446 26 .140 8 .100 1. .00 85 .71 ISG 716
ATOM 716 CD2 TRP 93 132 .230 25 .980 8 .855 1. .00 85 .71 ISG 717
ATOM 717 CDl TRP 93 133 .938 27 .366 8 .426 1. .00 85 .71 ISG 718
ATOM 718 NE1 TRP 93 133 .113 27 .968 9 .340 1. .00 85 .71 ISG 719
ATOM 719 CE2 TRP 93 132 .049 27 .130 9 .603 1. .00 85 .71 ISG 720
ATOM 720 CE3 TRP 93 131 .352 24 .948 8 .957 1. .00 85 .71 ISG 721
ATOM 721 CZ2 TRP 93 130 .998 27, .255 10 .471 1. .00 85 .71 ISG 722
ATOM 722 CZ3 TRP 93 130 .256 25, .094 9 .774 1. .00 85 .71 ISG 723
ATOM 723 CH2 TRP 93 130 .079 26, .234 10 .522 1, .00 85 .71 ISG 724
ATOM 724 C TRP 93 133 .674 24, .602 4 .658 1. .00 85 .71 ISG 725
ATOM 725 O TRP 93 133 .644 23, .415 4 .339 1. .00 85 .71 ISG 726
ATOM 726 N GLY 94 134 .224 25, .584 3 .926 1, .00 69 .57 ISG 727
ATOM 727 CA GLY 94 135, .002 25, .497 2 .738 1. .00 69 .57 ISG 728
ATOM 728 C GLY 94 135, .697 26, .812 2 .767 1. .00 69 .57 ISG 729
ATOM 729 O GLY 94 135, .050 27, .859 2 .758 1. .00 69 .57 ISG 730
ATOM 730 N PHE 95 137, .038 26, .808 2 .798 1. .00 64 .93 ISG 731
ATOM 731 CA PHE 95 137, .678 28, .070 2 .984 1. .00 64 .93 ISG 732
ATOM 732 CB PHE 95 138, .669 28, .064 4 .162 1. .00 64 .93 ISG 733
ATOM 733 CG PHE 95 139, .028 29, .476 4 .484 1. .00 64 .93 ISG 734
ATOM 734 CDl PHE 95 138, .121 30, .291 5 .122 1. .00 64. .93 ISG 735
ATOM 735 CD2 PHE 95 140, .270 29, .979 4 .179 1. .00 64 .93 ISG 736
ATOM 736 CE1 'PHE 95 138, .441 31, .593 5 .430 1. .00 64 .93 ISG 737
ATOM 737 CE2 PHE 95 140, .597 31. .279 4, .483 1. .00 64, .93 ISG 738
ATOM 738 CZ PHE 95 139, .680 32. .090 5, .108 1. .00 64 , .93 ISG 739
ATOM 739 C PHE 95 138. .387 28, .450 1, .735 1. .00 64 , .93 ISG 740
ATOM 740 O PHE 95 138. .944 27, .607 1, .033 1. .00 64. .93 ISG 741
ATOM 741 N GLU 96 138, .365 29, .765 1, .446 1. .00 68. .19 ISG 742
ATOM 742 CA GLU 96 138. .969 30. .327 0, .279 1. .00 68. .19 ISG 743
ATOM 743 CB GLU 96 138. .682 31. .829 0, .105 1. .00 68. .19 ISG 744
ATOM 744 CG GLU 96 139. .275 32. .429 -1, .171 1. .00 68. .19 ISG 745
ATOM 745 CD GLU 96 138. .909 33. .906 -1, .203 1. .00 68. .19 ISG 746
ATOM 746 OEl GLU 96 138. .241 34. .370 -0, .241 1. .00 68. .19 ISG 747
ATOM 747 OE2 GLU 96 139. .295 34. .591 -2, .188 1. .00 68. .19 ISG 748
ATOM 748 C GLU 96 140. .436 30. .150 0, .433 1. ,00 68. .19 ISG 749
ATOM 749 O GLU 96 140. .940 29. .902 1, .524 1. ,00 68. .19 ISG 750
ATOM 750 N SER 97 141. .170 30. .265 -0, .681 1. .00 77. .35 ISG 751
ATOM 751 CA SER 97 142. .571 29. .994 -0, .636 1. .00 77. .35 ISG 752
ATOM 752 CB SER 97 143. .271 30. ,180 -1, .993 1. .00 77. .35 ISG 753
ATOM 753 OG SER 97 142. ,753 29. ,256 -2. .940 1. .00 77. .35 ISG 754
ATOM 754 C SER 97 143. .244 30. ,897 0. .350 1. .00 77. ,35 ISG 755
ATOM 755 O SER 97 142. .752 31. .955 0. .737 1. 00 77. .35 ISG 756
ATOM 756 N PRO 98 144. ,345 30. .381 0. .824 1. 00 89. .65 ISG 757 ∞ aι oj oo oι oj
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ATOM 871 O GLU 111 145..525 23..488 5..957 1..00 59..82 ISG 872
ATOM 872 N LYS 112 147. .303 22. .204 5. ,477 1. .00 57. .76 ISG 873
ATOM 873 CA LYS 112 146. .473 21, .042 5. .532 1. .00 57. .76 ISG 874
ATOM 874 CB LYS 112 147. .234 19, .737 5. .236 1. .00 57. .76 ISG 875
ATOM 875 CG LYS 112 147. .734 19. .642 3. .793 1. .00 57. .76 ISG 876
ATOM 876 CD LYS 112 148. .748 18. .519 3. .566 1. .00 57. .76 ISG 877
ATOM 877 CE LYS 112 149. .244 18, .428 2. .121 1. .00 57. .76 ISG 878
ATOM 878 NZ LYS 112 148. .132 18, .030 1. .228 1. .00 57. .76 ISG 879
ATOM 879 C LYS 112 145. .866 20, .941 6. .900 1. .00 57, .76 ISG 880
ATOM 880 O LYS 112 144, .683 20, .628 7. .006 1. .00 57. .76 ISG 881
ATOM 881 N PRO 113 146. .616 21, .143 7. .952 1. .00 57. .45 ISG 882
ATOM 882 CA PRO 113 146, .046 21 .100 9, .275 1. .00 57. .45 ISG 883
ATOM 883 CD PRO 113 148, .025 20, .790 7. .961 1. .00 57, .45 ISG 884
ATOM 884 CB PRO 113 147, .213 20, .862 10. .238 1. .00 57. .45 ISG 885
ATOM 885 CG PRO 113 148, .477 21 .107 9. .394 1. .00 57. .45 ISG 886
ATOM 886 C PRO 113 145, .167 22 .247 9. .684 1. .00 57. .45 ISG 887
ATOM 887 O PRO 113 144. .180 22, .014 10. .380 1. .00 57, .45 ISG 888
ATOM 888 N ILE 114 145 .510 23 .488 9, .290 1 .00 58 .48 ISG 889
ATOM 889 CA ILE 114 144, .786 24 .648 9, .726 1. .00 58. .48 ISG 890
ATOM 890 CB ILE 114 145, .453 25. .928 9, .319 1. .00 58. .48 ISG 891
ATOM 891 CG2 ILE 114 144 .522 27 .089 9 .705 1 .00 58 .48 ISG 892
ATOM 892 CGI ILE 114 146, .852 26 .025 9, .949 1. .00 58, .48 ISG 893
ATOM 893 CDl ILE 114 146, .834 26. .016 11, .477 1. .00 58, .48 ISG 894
ATOM 894 C ILE 114 143 .407 24 .673 9 .149 1 .00 58 .48 ISG 895
ATOM 895 O ILE 114 142, .437 24 .906 9, .868 1, .00 58, .48 ISG 896
ATOM 896 N LEU 115 143 , .284 24. .422 7, .832 1. .00 61, .17 ISG 897
ATOM 897 CA LEU 115 142 .011 24 .501 7 .178 1 .00 61 .17 ISG 898
ATOM 898 CB LEU 115 142 .094 24 .166 5, .679 1, .00 61, .17 ISG 899
ATOM 899 CG LEU 115 140, .738 24. .240 4 , .957 1, .00 61, .17 ISG 900
ATOM 900 CD2 LEU 115 140 .829 23 .664 3 .534 1 .00 61 .17 ISG 901
ATOM 901 CDl LEU 115 140 .173 25 .666 4, .987 1, .00 61, .17 ISG 902
ATOM 902 C LEU 115 141, .090 23. .508 7, .797 1, .00 61, .17 ISG 903
ATOM 903 O LEU 115 139 .927 23 .810 8 .055 1 .00 61 .17 ISG 904
ATOM 904 N LYS 116 141, .595 22 .289 8, .054 1, .00 62, .93 ISG 905
ATOM 905 CA LYS 116 140, ,763 21. .252 8, .587 1, .00 62. .93 ISG 906
ATOM 906 CB LYS 116 141 .471 19 .882 8 .641 1 .00 62 .93 ISG 907
ATOM 907 CG LYS 116 142. .643 19 .771 9, .622 1, .00 62. .93 ISG 908
ATOM 908 CD LYS 116 142 , .227 19 .579 11, .082 1, .00 62. .93 ISG 909
ATOM 909 CE LYS 116 141 .598 18 .213 11 .364 1 .00 62 .93 ISG 910
ATOM 910 NZ LYS 116 142. .632 17 .156 11, .299 1, .00 62, .93 ISG 911
ATOM 911 C LYS 116 140. .277 21 .620 9, .955 1, .00 62, .93 ISG 912
ATOM 912 O LYS 116 139 .106 21 .416 10 .269 1, .00 62, .93 ISG 913
ATOM 913 N ASN 117 141, .161 22 .174 10, .808 1, .00 63, .02 ISG 914
ATOM 914 CA ASN 117 140, .803 22. .506 12, .160 1, .00 63. .02 ISG 915
ATOM 915 CB ASN 117 142, .011 22 .971 12, .992 1, .00 63. .02 ISG 916
ATOM 916 CG ASN 117 141, .584 23 .069 14, .451 1. .00 63. .02 ISG 917
ATOM 917 ODl ASN 117 140, .600 23. .726 14 , .786 1. .00 63. .02 ISG 918
ATOM 918 ND2 ASN 117 142, .346 22 .389 15, .349 1, .00 63, .02 ISG 919
ATOM 919 C ASN 117 139, .805 23 .615 12, .154 1, .00 63, .02 ISG 920
ATOM 920 O ASN 117 138, .859 23. .632 12, .939 1. .00 63. .02 ISG 921
ATOM 921 N LEU 118 140, .014 24 .591 11 .264 1, .00 65, .41 ISG 922
ATOM 922 CA LEU 118 139, .162 25 .731 11, .172 1, .00 65. .41 ISG 923
ATOM 923 CB LEU 118 139. .756 26. .754 10. .174 1. .00 65. .41 ISG 924
ATOM 924 CG LEU 118 138. .931 28 .019 9. .854 1, .00 65. .41 ISG 925
ATOM 925 CD2 LEU 118 137, .672 27. .688 9. .035 1, .00 65. .41 ISG 926
ATOM 926 CDl LEU 118 139. .792 29. .040 9. .093 1. .00 65. .41 ISG 927
ATOM 927 C LEU 118 137, .807 25 .296 10, .733 1. .00 65. .41 ISG 928 ATOM 928 O LEU 118 136..785 25..766 11.,235 1..00 65..41 ISG 929
ATOM 929 N ASN 119 137. .782 24, .374 9. ,767 1. ,00 66. .86 ISG 930
ATOM 930 CA ASN 119 136. .560 23, .893 9. .215 1. .00 66. .86 ISG 931
ATOM 931 CB ASN 119 136. .842 22. .869 8. .103 1. .00 66. .86 ISG 932
ATOM 932 CG ASN 119 135. .599 22. .702 7. ,256 1. .00 66. .86 ISG 933
ATOM 933 ODl ASN 119 134. .495 22, .554 7. .775 1. .00 66. .86 ISG 934
ATOM 934 ND2 ASN 119 135. .781 22 .737 5. .909 1. .00 66. .86 ISG 935
ATOM 935 C ASN 119 135. .806 23, .204 10, .306 1. .00 66, .86 ISG 936
ATOM 936 O ASN 119 134. .593 23, .359 10. .420 1. .00 66. .86 ISG 937
ATOM 937 N GLU 120 136. .516 22, .399 11. .119 1. .00 68. .34 ISG 938
ATOM 938 CA GLU 120 135. .923 21, .639 12. .180 1. .00 68. .34 ISG 939
ATOM 939 CB GLU 120 136. .841 20, .525 12. .722 1. .00 68, .34 ISG 940
ATOM 940 CG GLU 120 138. .132 21, .027 13. .367 1. .00 68. .34 ISG 941
ATOM 941 CD GLU 120 138. .924 19, .820 13. .848 1. .00 68. .34 ISG 942
ATOM 942 OEl GLU 120 138. .435 18, .675 13. .654 1. .00 68, .34 ISG 943
ATOM 943 OE2 GLU 120 140. .030 20, .027 14. .415 1. .00 68, .34 ISG 944
ATOM 944 C GLU 120 135. .491 22. .487 13. .340 1. .00 68 .34 ISG 945
ATOM 945 O GLU 120 134. .438 22. .245 13. .907 1. .00 68. .34 ISG 946
ATOM 946 N MET 121 136. .257 23. .501 13. .772 1. .00 71, .98 ISG 947
ATOM 947 CA MET 121 135, .827 24 .194 14. .960 1. .00 71, .98 ISG 948
ATOM 948 CB MET 121 136. ,826 25, .274 15, .407 1. .00 71 .98 ISG 949
ATOM 949 CG MET 121 138. .176 24, .710 15, .856 1. .00 71, .98 ISG 950
ATOM 950 SD MET 121 139. .378 25, .965 16, .389 1. .00 71, .98 ISG 951
ATOM 951 CE MET 121 139, .737 26, .567 14, .714 1. .00 71, .98 ISG 952
ATOM 952 C MET 121 134. .532 24, .871 14, .695 1. .00 71 .98 ISG 953
ATOM 953 O MET 121 133. .612 24 , .893 15, .512 1. .00 71, .98 ISG 954
ATOM 954 N LEU 122 134. .462 25, .462 13, .508 1. .00 72, .70 ISG 955
ATOM 955 CA LEU 122 133. .365 26, .247 13, .078 1. .00 72, .70 ISG 956
ATOM 956 CB LEU 122 133. .855 26 .977 11 .835 1 .00 72 .70 ISG 957
ATOM 957 CG LEU 122 134. .881 28, .112 12, .077 1. .00 72, .70 ISG 958
ATOM 958 CD2 LEU 122 135. .438 28, .582 10, .728 1, .00 72, .70 ISG 959
ATOM 959 CDl LEU 122 136. .046 27, .725 13 .004 1. .00 72 .70 ISG 960
ATOM 960 C LEU 122 132. .130 25 .391 12 .912 1, .00 72 .70 ISG 961
ATOM 961 O LEU 122 131. .069 25, .758 13, .418 1, .00 72, .70 ISG 962
ATOM 962 N CYS 123 132. .223 24, .202 12, .265 1, .00 69, .56 ISG 963
ATOM 963 CA CYS 123 131. .026 23 .422 12 .075 1. .00 69, .56 ISG 964
ATOM 964 CB CYS 123 131, .197 22 .087 11 .295 1, .00 69 .56 ISG 965
ATOM 965 SG CYS 123 132. .108 22 , .108 9, .726 1, .00 69 .56 ISG 966
ATOM 966 C CYS 123 130. .492 23, .075 13. .437 1, .00 69, .56 ISG 967
ATOM 967 O CYS 123 129, .298 23, .259 13 .648 1, .00 69 .56 ISG 968
ATOM 968 N PRO 124 131, .285 22 .566 14 .366 1, .00 65 .57 ISG 969
ATOM 969 CA PRO 124 130. .741 22, .410 15. .678 1, .00 65, .57 ISG 970
ATOM 970 CD PRO 124 131. .854 21, .257 14. .079 1. .00 65. .57 ISG 971
ATOM 971 CB PRO 124 131, .737 21, .569 16. .475 1, .00 65. .57 ISG 972
ATOM 972 CG PRO 124 132. .517 20, .808 15, .393 1, .00 65, .57 ISG 973
ATOM 973 C PRO 124 130. .254 23. .614 16 .409 1, .00 65, .57 ISG 974
ATOM 974 O PRO 124 129. .380 23, .442 17, .255 1. .00 65. .57 ISG 975
ATOM 975 N ILE 125 130, .779 24, .823 16, .159 1, .00 57, .35 ISG 976
ATOM 976 CA ILE 125 130, .202 25. .915 16, .881 1. .00 57, .35 ISG 977
ATOM 977 CB ILE 125 130. .850 27. .230 16 .560 1, .00 57, .35 ISG 978
ATOM 978 CG2 ILE 125 130. .058 28, .335 17, .278 1. .00 57, .35 ISG 979
ATOM 979 CGI ILE 125 132. .341 27, .197 16, .938 1, .00 57, .35 ISG 980
ATOM 980 CDl ILE 125 132. .588 26, .938 18, .424 1. .00 57, .35 ISG 981
ATOM 981 C ILE 125 128. .777 25, .991 16 .432 1. .00 57, .35 ISG 982
ATOM 982 O ILE 125 127. .856 26. .092 17. .243 1. .00 57, .35 ISG 983
ATOM 983 N ILE 126 128. .565 25. .902 15, .105 1. .00 50. .08 ISG 984
ATOM 984 CA ILE 126 127. .251 25. .993 14, .539 1. .00 50. .08 ISG 985 ATOM 985 CB ILE 126 127..258 25..928 13..040 1.,00 50.,08 ISG 986
ATOM 986 CG2 ILE 126 125, .798 25. .863 12. .562 1. .00 50. .08 ISG 987
ATOM 987 CGI ILE 126 128, .041 27. .119 12. .462 1. .00 50. .08 ISG 988
ATOM 988 CDl ILE 126 127. .451 28. .477 12. .838 1. .00 50. .08 ISG 989
ATOM 989 C ILE 126 126. .421 24. .859 15. .037 1. ,00 50. .08 ISG 990
ATOM 990 O ILE 126 125, .277 25. .052 15. .443 1. .00 50. .08 ISG 991
ATOM 991 N ALA 127 126, .978 23. .638 15. .030 1. .00 44. .89 ISG 992
ATOM 992 CA ALA 127 126, .217 22 .504 15, .458 1. .00 44. .89 ISG 993
ATOM 993 CB ALA . 127 126 .999 21 .185 15, .347 1. .00 44, .89 ISG 994
ATOM 994 C ALA 127 125, .838 22. .680 16. .895 1. .00 44. .89 ISG 995
ATOM 995 O ALA 127 124, .693 22. .441 17. .267 1. .00 44. .89 ISG 996
ATOM 996 N SER 128 126, .785 23, .120 17, .743 1. .00 40. .04 ISG 997
ATOM 997 CA SER 128 126 .532 23 .256 19, .152 1. .00 40. .04 ISG 998
ATOM 998 CB SER 128 127 .796 23 .625 19, .947 1, .00 40. .04 ISG 999
ATOM 999 OG SER 128 128, .751 22 , .578 19. .859 1. .00 40. .04 1SG1000
ATOM 1000 C SER 128 125, .531 24, .339 19. .382 1. .00 40. .04 1SG1001
ATOM 1001 O SER 128 124, .711 24, .259 20, .294 1. .00 40. .04 1SG1002
ATOM 1002 N GLU 129 125 .574 25, .382 18, .539 1. .00 38, .50 1SG1003
ATOM 1003 CA GLU 129 124 .716 26 .515 18, .680 1. .00 38, .50 1SG1004
ATOM 1004 CB GLU 129 124 .989 27 .578 17 .600 1. .00 38, .50 1SG1005
ATOM 1005 CG GLU 129 124, .104 28. .823 17, .687 1. .00 38. .50 1SG1006
ATOM 1006 CD GLU 129 122, .914 28. .619 16, .760 1. .00 38. .50 1SG1007
ATOM 1007 OEl GLU 129 122 .732 27. .472 16, .273 1, .00 38. .50 1SG1008
ATOM 1008 OE2 GLU 129 122 .177 29. .611 16, .520 1. .00 38. .50 1SG1009
ATOM 1009 C GLU 129 123 .307 26 .058 18 .555 1. .00 38. .50 1SG1010
ATOM 1010 O GLU 129 122 .437 26 .553 19 .263 1, .00 38 .50 1SG1011
ATOM 1011 N VAL 130 123, .030 25. .097 17, .658 1. .00 37, .83 1SG1012
ATOM 1012 CA VAL 130 121, .668 24. .684 17, .516 1, .00 37, .83 1SG1013
ATOM 1013 CB VAL 130 121 .434 23, .663 16, .436 1, .00 37, .83 1SG1014
ATOM 1014 CGI VAL 130 121 .989 22 .299 16, .871 1, .00 37 .83 1SG1015
ATOM 1015 CG2 VAL 130 119 .928 23, .638 16 .131 1, .00 37 .83 1SG1016
ATOM 1016 C VAL 130 121. .207 24, .114 18, .816 1. .00 37, .83 1SG1017
ATOM 1017 O VAL 130 120. .081 24, .361 19, .244 1. .00 37, .83 1SG1018
ATOM 1018 N LYS 131 122, .076 23, .342 19, .493 1, .00 36, .89 1SG1019
ATOM 1019 CA LYS 131 121 .688 22, .750 20, .738 1, .00 36, .89 1SG1020
ATOM 1020 CB LYS 131 122 .818 21 .927 21, .381 1, .00 36, .89 1SG1021
ATOM 1021 CG LYS 131 122 .427 21. .281 22 .711 1, .00 36, .89 1SG1022
ATOM 1022 CD LYS 131 123, .416 20, .214 23. .185 1, .00 36, .89 1SG1023
ATOM 1023 CE LYS 131 123, .029 19, .565 24. .515 1. .00 36, .89 1SG1024
ATOM 1024 NZ LYS 131 124, .037 18, .550 24, .894 1. .00 36, .89 1SG1025
ATOM 1025 C LYS 131 121 .352 23, .869 21, .671 1, .00 36, .89 1SG1026
ATOM 1026 O LYS 131 120 .376 23, .798 22, .413 1, .00 36, .89 1SG1027
ATOM 1027 N ALA 132 122 .166 24 .940 21, .645 1, .00 35, .93 1SG1028
ATOM 1028 CA ALA 132 121, .962 26 , .084 22. .486 1. .00 35. .93 1SG1029
ATOM 1029 CB ALA 132 123, .073 27, .137 22. .336 1. .00 35. .93 1SG1030
ATOM 1030 C ALA 132 120, .665 26, .744 22. .115 1. .00 35. .93 1SG1031
ATOM 1031 O ALA 132 119, .934 27, .216 22. .983 1. .00 35. .93 1SG1032
ATOM 1032 N LEU 133 120, .353 26, .787 20. .803 1. .00 33. .94 1SG1033
ATOM 1033 CA LEU 133 119. .171 27. .396 20. .264 1. .00 33. .94 1SG1034
ATOM 1034 CB LEU 133 119, .073 27. .275 18. .735 1. .00 33. .94 1SG1035
ATOM 1035 CG LEU 133 120, .175 28. .048 17. .991 1. .00 33. .94 1SG1036
ATOM 1036 CD2 LEU 133 120, .233 29. .512 18. .455 1. .00 33. .94 1SG1037
ATOM 1037 CDl LEU 133 120, .027 27. .903 16. .468 1. .00 33. .94 1SG1038
ATOM 1038 C LEU 133 118, .019 26. .657 20. .847 1. .00 33. .94 1SG1039
ATOM 1039 O LEU 133 116. .952 27. .223 21. .078 1. .00 33. .94 1SG1040
ATOM 1040 N ASN 134 118. .225 25. .357 21. .111 1. .00 31. .40 1SG1041
ATOM 1041 CA ASN 134 117. .190 24. .530 21. .646 1. ,00 31. .40 1SG1042 ATOM 1042 CB ASN 134 117.671 23.108 21.981 1.00 31.40 1SG1043
ATOM 1043 CG ASN 134 117. 986 22. 392 20. 675 1. 00 31. .40 1SG1044
ATOM 1044 ODl ASN 134 119. 092 21. 891 20. 479 1. 00 31. 40 1SG1045
ATOM 1045 ND2 ASN 134 116. 986 22. 338 19. 755 1. ,00 31. ,40 1SG1046
ATOM 1046 C ASN 134 116. 718 25. 154 22. .919 1. 00 31. 40 1SG1047
ATOM 1047 O ASN 134 115. ,532 25. 106 23. ,234 1. .00 31. ,40 1SG1048
ATOM 1048 N ALA 135 117. 637 25. ,763 23. ,689 1. .00 31. ,55 1SG1049
ATOM 1049 CA ALA 135 117. ,269 26. 358 24. ,941 1. .00 31. .55 1SG1050
ATOM 1050 CB ALA 135 118. ,464 26. .993 25. .672 1. .00 31. .55 1SG1051
ATOM 1051 C ALA 135 116. ,264 27. .443 24. .698 1. .00 31. .55 1SG1052
ATOM 1052 O ALA 135 115. ,306 27. ,589 25. .453 1. .00 31. .55 1SG1053
ATOM 1053 N ASN 136 116. .457 28. ,248 23. .638 1. .00 34. .91 1SG1054
ATOM 1054 CA ASN 136 115. .551 29. ,327 23. .360 1. .00 34. .91 1SG1055
ATOM 1055 CB ASN 136 116. .001 30. ,183 22. .164 1. .00 34. .91 1SG1056
ATOM 1056 CG ASN 136 115. .128 31. ,429 22, .108 1. .00 34. .91 1SG1057
ATOM 1057 ODl ASN 136 114, .102 31. .521 22. .780 1. .00 34. .91 1SG1058
ATOM 1058 ND2 ASN 136 115. .546 32. .420 21. .275 1. .00 34. .91 1SG1059
ATOM 1059 C ASN 136 114, .207 28. .757 23, .026 1. .00 34, .91 1SG1060
ATOM 1060 O ASN 136 113 , .173 29. .258 23 .463 1. .00 34, .91 1SG1061
ATOM 1061 N LEU 137 114, .206 27. .666 22, .246 1, .00 41. .62 1SG1062
ATOM 1062 CA LEU 137 113, .028 27. .015 21, .756 1, .00 41 .62 1SG1063
ATOM 1063 CB LEU 137 113, .396 25. .860 20 .792 1, .00 41, .62 1SG1064
ATOM 1064 CG LEU 137 112. .243 25. .058 20. .141 1. .00 41, .62 1SG1065
ATOM 1065 CD2 LEU 137 111. .387 24. .287 21. .159 1. .00 41, .62 1SG1066
ATOM 1066 CDl LEU 137 112 , .804 24. .097 19. .080 1. .00 41, .62 1SG1067
ATOM 1067 C LEU 137 112. .240 26. .484 22. .919 1. .00 41. .62 1SG1068
ATOM 1068 O LEU 137 111. .016 26. .405 22. .852 1. .00 41 .62 1SG1069
ATOM 1069 N SER 138 112. .920 26. .083 24 .009 1. .00 48, .27 1SG1070
ATOM 1070 CA SER 138 112. .286 25. .493 25. .158 1, .00 48 .27 1SG1071
ATOM 1071 CB SER 138 113. .272 24. .885 26 .172 1. .00 48, .27 1SG1072
ATOM 1072 OG SER 138 113, .962 25, .910 26 .869 1. .00 48 .27 1SG1073
ATOM 1073 C SER 138 111, .474 26 .514 25 .887 1. .00 48 .27 1SG1074
ATOM 1074 O SER 138 110 .835 26, .198 26 .889 1. .00 48 .27 1SG1075
ATOM 1075 N THR 139 111, .511 27, .774 25 .426 1. .00 54 .11 1SG1076
ATOM 1076 CA THR 139 110 .763 28 .843 26 .020 1, .00 54 .11 1SG1077
ATOM 1077 CB THR 139 111 .092 30. .187 25 .452 1 .00 54 .11 1SG1078
ATOM 1078 OGl THR 139 112 .471 30 .471 25 .627 1, .00 54 .11 1SG1079
ATOM 1079 CG2 THR 139 110 .244 31. .233 26 .190 1 .00 54 .11 1SG1080
ATOM 1080 C THR 139 109 .311 28 .601 25 .757 1, .00 54 .11 1SG1081
ATOM 1081 O THR 139 108 .450 29 .105 26 .475 1 .00 54 .11 1SG1082
ATOM 1082 N LEU 140 109 .011 27 .851 24 .681 1 .00 57, .63 1SG1083
ATOM 1083 CA LEU 140 107 .670 27 .575 24 .260 1 .00 57 .63 1SG1084
ATOM 1084 CB LEU 140 107 .660 26 .592 23 .069 1 .00 57, .63 1SG1085
ATOM 1085 CG LEU 140 106 .294 26 .316 22 .412 1 .00 57 .63 1SG1086
ATOM 1086 CD2 LEU 140 105, .686 27 .592 21 .812 1, .00 57, .63 1SG1087
ATOM 1087 CDl LEU 140 105, .346 25, .582 23 .365 1 .00 57. .63 1SG1088
ATOM 1088 C LEU 140 106, .930 26 .974 25 .426 1, .00 57. .63 1SG1089
ATOM 1089 O LEU 140 107, .445 26 .098 26 .119 1 .00 57, .63 1SG1090
ATOM 1090 N GLU 141 105, .694 27 .463 25 .688 1, .00 56, .80 1SG1091
ATOM 1091 CA GLU 141 104 .969 27 .012 26 .846 1, .00 56, .80 1SG1092
ATOM 1092 CB GLU 141 103, .838 27 .972 27 .253 1 .00 56, .80 1SG1093
ATOM 1093 CG GLU 141 104 .354 29 .333 27 .720 1, .00 56 .80 1SG1094
ATOM 1094 CD GLU 141 105, .154 29 .099 28 .992 1 .00 56. .80 1SG1095
ATOM 1095 OEl GLU 141 105 .026 27 .987 29 .571 1, .00 56 .80 1SG1096
ATOM 1096 OE2 GLU 141 105 .903 30 .026 29 .401 1 .00 56. .80 1SG1097
ATOM 1097 C GLU 141 104 .352 25 .670 26 .606 1, .00 56. .80 1SG1098
ATOM 1098 O GLU 141 103 .544 25 .510 25 .700 1 .00 56. .80 1SG1099 ATOM 1099 N VAL 142 104..775 24..649 27..381 1.,00 55..50 1SG1100
ATOM 1100 CA VAL 142 104. .193 23. .334 27. .346 1. .00 55. .50 1SG1101
ATOM 1101 CB VAL 142 105. .135 22. .284 27. .846 1. .00 55. .50 1SG1102
ATOM 1102 CGI VAL 142 106. .225 22, .067 26. .785 1. .00 55. .50 1SG1103
ATOM 1103 CG2 VAL 142 105. .717 22. .778 29, .179 1. .00 55, .50 1SG1104
ATOM 1104 C VAL 142 102. .923 23. .266 28, .141 1. .00 55. .50 1SG1105
ATOM 1105 O VAL 142 101, .884 22. .830 27, .645 1. .00 55. .50 1SG1106
ATOM 1106 N LEU 143 102, .979 23, .708 29, .415 1. .00 53. .03 1SG1107
ATOM 1107 CA LEU 143 101, .817 23, .676 30, .253 1. .00 53. .03 1SG1108
ATOM 1108 CB LEU 143 102, .031 23, .005 31, .627 1. .00 53. .03 1SG1109
ATOM 1109 CG LEU 143 102 .480 21, .530 31, .597 1. .00 53. .03 1SG1110
ATOM 1110 CD2 LEU 143 103, .895 21. .382 31. .023 1. .00 53 , .03 1SG1111
ATOM llll CDl LEU 143 101. .441 20. .628 30. .915 1. .00 53. .03 1SG1112
ATOM 1112 C LEU 143 101. .529 25. .104 30. .550 1. ,00 53, .03 1SG1113
ATOM 1113 O LEU 143 102, .162 25. .703 31. .419 1. .00 53. .03 1SG1114
ATOM 1114 N THR 144 100, .550 25. .689 29. .844 1. .00 49. .99 1SG1115
ATOM 1115 CA THR 144 100, .297 27. .078 30. .063 1. .00 49, .99 1SG1116
ATOM 1116 CB THR 144 99. .951 27. .793 28, .791 1. .00 49, .99 1SG1117
ATOM 1117 OGl THR 144 100, .997 27. .626 27, .845 1. .00 49, .99 1SG1118
ATOM 1118 CG2 THR 144 99. .749 29, .286 29, .095 1. .00 49 .99 1SG1119
ATOM 1119 C THR 144 99. .125 27, .182 30, .980 1. .00 49 .99 1SG1120
ATOM 1120 O THR 144 98, .013 26 , .785 30, .636 1. .00 49, .99 1SG1121
ATOM 1121 N LYS 145 99, .359 27. .725 32. .190 1. .00 48 .74 1SG1122
ATOM 1122 CA LYS 145 98, .302 27, .860 33. .148 1. .00 48, .74 1SG1123
ATOM 1123 CB LYS 145 98, .799 27, .788 34. .601 1. .00 48 .74 1SG1124
ATOM 1124 CG LYS 145 97, .671 27, .838 35. .630 1. .00 48 .74 1SG1125
ATOM 1125 CD LYS 145 98. .144 27, .613 37. .065 1. .00 48 .74 1SG1126
ATOM 1126 CE LYS 145 98, .569 28, .907 37. .762 1. .00 48 .74 1SG1127
ATOM 1127 NZ LYS 145 97, .389 29, .774 37. .977 1. .00 48 .74 1SG1128
ATOM 1128 C LYS 145 97, .708 29, .216 32, .948 1. .00 48 .74 1SG1129
ATOM 1129 O LYS 145 98 .363 30. .230 33 .182 1. .00 48 .74 1SG1130
ATOM 1130 N ILE 146 96 .465 29. .260 32 .431 1. .00 47 .04 1SG1131
ATOM 1131 CA ILE 146 95 .775 30. .495 32 .202 1. .00 47 .04 1SG1132
ATOM 1132 CB ILE 146 94 .670 30. .356 31 .194 1. .00 47 .04 1SG1133
ATOM 1133 CG2 ILE 146 95 .326 29. .995 29 .850 1. .00 47 .04 1SG1134
ATOM 1134 CGI ILE 146 93 .607 29. .350 31 .660 1. .00 47 .04 1SG1135
ATOM 1135 CDl ILE 146 92 .370 29. .323 30 .763 1, .00 47 .04 1SG1136
ATOM 1136 C ILE 146 95 .258 31. .106 33 .466 1. .00 47 .04 1SG1137
ATOM 1137 O ILE 146 95 .390 32. .311 33, .672 1. .00 47 .04 1SG1138
ATOM 1138 N ASP 147 94 .626 30. .295 34 .337 1. .00 46 .23 1SG1139
ATOM 1139 CA ASP 147 94 .109 30. .819 35 .566 1. .00 46 .23 1SG1140
ATOM 1140 CB ASP 147 92 .688 31. .408 35, .456 1. .00 46 .23 1SG1141
ATOM 1141 CG ASP 147 91 .706 30. .345 34, .991 1. .00 46 .23 1SG1142
ATOM 1142 ODl ASP 147 92 .127 29. .174 34, .791 1. .00 46, .23 1SG1143
ATOM 1143 OD2 ASP 147 90 .510 30. .704 34, .821 1. .00 46 .23 1SG1144
ATOM 1144 C ASP 147 94 .141 29. .725 36, .581 1. .00 46 .23 1SG1145
ATOM 1145 O ASP 147 94 .831 28. .724 36, .410 1. .00 46 .23 1SG1146
ATOM 1146 N ASN 148 93 .418 29. .904 37, .699 1. .00 46 .27 1SG1147
ATOM 1147 CA ASN 148 93 .445 28, .910 38, .728 1. .00 46, .27 1SG1148
ATOM 1148 CB ASN 148 92 .706 29, .340 40, .010 1, .00 46 .27 1SG1149
ATOM 1149 CG ASN 148 91 .228 29, .542 39, .706 1. .00 46, .27 1SG1150
ATOM 1150 ODl ASN 148 90 .370 28, .960 40, .369 1. .00 46 .27 1SG1151
ATOM 1151 ND2 ASN 148 90 .912 30, .391 38, .692 1. .00 46 .27 1SG1152
ATOM 1152 C ASN 148 92 .841 27, .627 38. .233 1. .00 46 .27 1SG1153
ATOM 1153 O ASN 148 93 .329 26, .551 38. .573 1. .00 46, .27 1SG1154
ATOM 1154 N TYR 149 91 .728 27, .706 37. .469 1. .00 48 .37 1SG1155
ATOM 1155 CA TYR 149 91, .035 26. .526 37. .021 1. ,00 48. .37 1SG1156 ATOM 1156 CB TYR 149 89..612 26,.842 36..519 1..00 48,.37 1SG1157
ATOM 1157 CG TYR 149 88. .831 27 .393 37 .667 1. .00 48 .37 1SG1158
ATOM 1158 CDl TYR 149 88 .232 26 .546 38 .572 1. .00 48 .37 1SG1159
ATOM 1159 CD2 TYR 149 88. .709 28 .752 37 .852 1, .00 48 .37 1SG1160
ATOM 1160 CE1 TYR 149 87. .515 27, .045 39. .635 1. .00 48, .37 1SG1161
ATOM 1161 CE2 TYR 149 87. .992 29 .258 38 .913 1. .00 48 .37 1SG1162
ATOM 1162 CZ TYR 149 87 .393 28 .403 39 .807 1 .00 48 .37 1SG1163
ATOM 1163 OH TYR 149 86. .658 28 .914 40 .898 1. .00 48, .37 1SG1164
ATOM 1164 C TYR 149 91. .719 25, .727 35. .936 1. .00 48 .37 1SG1165
ATOM 1165 O TYR 149 91, .984 24 .541 36 .126 1, .00 48 .37 1SG1166
ATOM 1166 N THR 150 92 .069 26 .337 34 .780 1, .00 53 .02 1SG1167
ATOM 1167 CA THR 150 92, .531 25 .492 3 .705 1. .00 53, .02 1SG1168
ATOM 1168 CB THR 150 91. .568 25, .416 32 .559 1, .00 53 .02 1SG1169
ATOM 1169 OGl THR 150 91, .358 26, .707 32 .007 1, .00 53, .02 1SG1170
ATOM 1170 CG2 THR 150 90 .241 24 .837 33 .077 1. .00 53 .02 1SG1171
ATOM 1171 C THR 150 93, .866 25 .896 33 .157 1, .00 53 .02 1SG1172
ATOM 1172 O THR 150 94, .423 26 .937 33 .503 1, .00 53 .02 1SG1173
ATOM 1173 N LEU 151 94, .408 25 .001 32 .294 1, .00 58 .67 1SG1174
ATOM 1174 CA LEU 151 95 .686 25 .109 31 .643 1. .00 58 .67 1SG1175
ATOM 1175 CB LEU 151 96, .710 24, .037 32 .064 1, .00 58 .67 1SG1176
ATOM 1176 CG LEU 151 97 .018 23 .927 33 .565 1, .00 58 .67 1SG1177
ATOM 1177 CD2 LEU 151 97, .292 25 .293 34 .195 1, .00 58 .67 1SG1178
ATOM 1178 CDl LEU 151 98 .147 22 .913 33 .815 1, .00 58 .67 1SG1179
ATOM 1179 C LEU 151 95 .462 24 .755 30 .205 1. .00 58, .67 1SG1180
ATOM 1180 O LEU 151 94 .396 24 .276 29 .823 1, .00 58 .67 1SG1181
ATOM 1181 N LEU 152 96, .505 24, .979 29, .384 1. .00 64, .78 1SG1182
ATOM 1182 CA LEU 152 96 .526 24 .736 27 .970 1. .00 64 .78 1SG1183
ATOM 1183 CB LEU 152 97 .030 26 .017 27 .280 1 .00 64 .78 1SG1184
ATOM 1184 CG LEU 152 96, .788 26 .188 25 .780 1. .00 64 .78 1SG1185
ATOM 1185 CD2 LEU 152 95, .365 26, .712 25, .572 1. .00 64 .78 1SG1186
ATOM 1186 CDl LEU 152 97, .205 24 .961 24 .951 1. .00 64 .78 1SG1187
ATOM 1187 C LEU 152 97 .655 23 .761 27 .785 1. .00 64 .78 1SG1188
ATOM 1188 O LEU 152 98, .743 23. .992 28, .312 1. .00 64 .78 1SG1189
ATOM 1189 N ASP 153 97, .463 22. .652 27. .042 1. .00 66 .95 1SG1190
ATOM 1190 CA ASP 153 98, .581 21, .754 26, .907 1. .00 66, .95 1SG1191
ATOM 1191 CB ASP 153 98 .246 20 .285 27 .202 1, .00 66 .95 1SG1192
ATOM 1192 CG ASP 153 99, .569 19, .574 27, .439 1. .00 66 ,95 1SG1193
ATOM 1193 ODl ASP 153 100. .502 19, .742 26 .606 1, .00 66 .95 1SG1194
ATOM 1194 OD2 ASP 153 99. .666 18, .852 28, .466 1. .00 66, .95 1SG1195
ATOM 1195 C ASP 153 99. .111 21, .836 25 .505 1. .00 66, ,95 1SG1196
ATOM 1196 O ASP 153 98. .546 21, .274 24, .571 1. .00 66, .95 1SG1197
ATOM 1197 N TYR 154 100. .204 22, .601 25 .352 1. .00 65, .47 1SG1198
ATOM 1198 CA TYR 154 100. .990 22, .869 24 , .180 1. .00 65, ,47 1SG1199
ATOM 1199 CB TYR 154 101, .700 24, .226 24, .157 1. .00 65, .47 1SG1200
ATOM 1200 CG TYR 154 100. .663 25, .261 23, .890 1. .00 65. .47 1SG1201
ATOM 1201 CDl TYR 154 99. .983 25, .243 22, .694 1. .00 65. .47 1SG1202
ATOM 1202 CD2 TYR 154 100. .390 26. .262 24. .795 1. .00 65. .47 1SG1203
ATOM 1203 CE1 TYR 154 99. .026 26. .187 22, .411 1. ,00 65. .47 1SG1204
ATOM 1204 CE2 TYR 154 99. .433 27. .212 24. .516 1. ,00 65. .47 1SG1205
ATOM 1205 CZ TYR 154 98. .747 27. .173 23. .325 1. ,00 65. .47 1SG1206
ATOM 1206 OH TYR 154 97. .765 28. .145 23. .036 1. .00 65, .47 1SG1207
ATOM 1207 C TYR 154 101. .988 21. .801 23. .828 1. ,00 65. .47 1SG1208
ATOM 1208 O TYR 154 102. ,726 21. ,979 22. .864 1. 00 65. ,47 1SG1209
ATOM 1209 N SER 155 102. ,191 20. ,779 24. .681 1. ,00 59. ,39 1SG1210
ATOM 1210 CA SER 155 103. .232 19. .799 24. .469 1. ,00 59, .39 1SG1211
ATOM 1211 CB SER 155 103. .160 18. .611 25. ,444 1. 00 59. .39 1SG1212
ATOM 1212 OG SER 155 104. 205 17. .689 25. ,170 1. 00 59. .39 1SG1213 ATOM 1213 C SER 155 103..244 19..237 23..079 1.00 59..39 1SG1214
ATOM 1214 O SER 155 102. .208 18. .936 22. .490 1. .00 59. .39 1SG1215
ATOM 1215 N LEU 156 104. .471 19. .081 22. .525 1. .00 51. .09 1SG1216
ATOM 1216 CA LEU 156 104. .654 18. .545 21. .206 1. .00 51. .09 1SG1217
ATOM 1217 CB LEU 156 106. .049 18. .804 20. .609 1. ,00 51. .09 1SG1218
ATOM 1218 CG LEU 156 106. .324 20. .288 20. .289 1. ,00 51. .09 1SG1219
ATOM 1219 CD2 LEU 156 107. .597 20, .446 19, .444 1. .00 51. .09 1SG1220
ATOM 1220 CDl LEU 156 106. .340 21, .154 21, .560 1. .00 51. .09 1SG1221
ATOM 1221 C LEU 156 104, .429 17, .071 21, .245 1. .00 51. .09 1SG1222
ATOM 1222 O LEU 156 104, .962 16, .360 22, .095 1. .00 51. .09 1SG1223
ATOM 1223 N ILE 157 103, .572 16, .597 20, .324 1. .00 43, .82 1SG1224
ATOM 1224 CA ILE 157 103, .236 15, .217 20, .156 1. .00 43 , .82 1SG1225
ATOM 1225 CB ILE 157 101, .990 15, .023 19, .341 1. .00 43, .82 1SG1226
ATOM 1226 CG2 ILE 157 101. .837 13, .524 19, .037 1. .00 43 , .82 1SG1227
ATOM 1227 CGI ILE 157 100, .787 15, .625 20, .092 1. .00 43, .82 1SG1228
ATOM 1228 CDl ILE 157 99 .512 15. .717 19, .256 1. .00 43. .82 1SG1229
ATOM 1229 C ILE 157 104 .365 14, .473 19, .522 1. .00 43 .82 1SG1230
ATOM 1230 O ILE 157 104 .595 13 .316 19 .861 1, .00 43 .82 1SG1231
ATOM 1231 N SER 158 105 .068 15, .092 18 .547 1. .00 38 .12 1SG1232
ATOM 1232 CA SER 158 106 .138 14 .411 17 .867 1. .00 38 .12 1SG1233
ATOM 1233 CB SER 158 105 .685 13 .736 16 .563 1. .00 38 .12 1SG1234
ATOM 1234 OG SER 158 104 .709 12 .743 16 .846 1, .00 38 .12 1SG1235
ATOM 1235 C SER 158 107, .200 15, .415 17, .516 1. .00 38, .12 1SG1236
ATOM 1236 O SER 158 107, .036 16, .612 17, .742 1, .00 38, .12 1SG1237
ATOM 1237 N SER 159 108, .338 14, .939 16, .964 1. .00 36 .59 1SG1238
ATOM 1238 CA SER 159 109, .425 15. .817 16, .618 1. .00 36 .59 1SG1239
ATOM 1239 CB SER 159 110, .743 15. .085 16, .315 1. .00 36, .59 1SG1240
ATOM 1240 OG SER 159 111, .217 14 .440 17, .488 1. .00 36 .59 1SG1241
ATOM 1241 C SER 159 109, .036 16. .609 15, .410 1. .00 36 .59 1SG1242
ATOM 1242 O SER 159 108, .186 16. .199 14, .622 1. .00 36 .59 1SG1243
ATOM 1243 N PRO 160 109, .648 17 .753 15, .256 1. .00 36 .05 1SG1244
ATOM 1244 CA PRO 160 109, .303 18, .593 14 .145 1, .00 36 .05 1SG1245
ATOM 1245 CD PRO 160 110, .057 18 .536 16 .413 1, .00 36 .05 1SG1246
ATOM 1246 CB PRO 160 109 .911 19 .960 14 .444 1. .00 36 .05 1SG1247
ATOM 1247 CG PRO 160 109 .930 20 .009 15 .984 1. .00 36 .05 1SG1248
ATOM 1248 C PRO 160 109 .702 18 .008 12 .836 1, .00 36 .05 1SG1249
ATOM 1249 O PRO 160 110 .810 17 .487 12 .707 1. .00 36 .05 1SG1250
ATOM 1250 N GLU 161 108, .812 18 .115 11 .838 1. .00 36 .38 1SG1251
ATOM 1251 CA GLU 161 109 .107 17 .549 10 .564 1, .00 36 .38 1SG1252
ATOM 1252 CB GLU 161 107 .907 16 .840 9 .913 1, .00 36 .38 1SG1253
ATOM 1253 CG GLU 161 106 .745 17 .788 9 .604 1, .00 36 .38 1SG1254
ATOM 1254 CD GLU 161 105 .625 16 .987 8 .954 1. .00 36 .38 1SG1255
ATOM 1255 OEl GLU 161 105 .762 15 .737 8 .867 1. .00 36 .38 1SG1256
ATOM 1256 OE2 GLU 161 104 .618 17 .616 8 .533 1, .00 36 .38 1SG1257
ATOM 1257 C GLU 161 109 .483 18 .660 9 .647 1, .00 36 .38 1SG1258
ATOM 1258 O GLU 161 108 , .906 19, .746 9, .688 1. .00 36, .38 1SG1259
ATOM 1259 N ILE 162 110, .484 18, .407 8, .788 1. .00 37, .77 1SG1260
ATOM 1260 CA ILE 162 110, .853 19, .395 7. .824 1. .00 37, .77 1SG1261
ATOM 1261 CB ILE 162 112 , .333 19, .625 7, .696 1. .00 37, .77 1SG1262
ATOM 1262 CG2 ILE 162 112 , .841 20, .171 9, .041 1. .00 37, .77 1SG1263
ATOM 1263 CGI ILE 162 113, .055 18, .349 7, .235 1. .00 37, .77 1SG1264
ATOM 1264 CDl ILE 162 112. .982 17, .209 8, .249 1. .00 37, .77 1SG1265
ATOM 1265 C ILE 162 110, .349 18. .877 6, .521 1. .00 37, .77 1SG1266
ATOM 1266 O ILE 162 110, .581 17. .721 6, .169 1. .00 37, .77 1SG1267
ATOM 1267 N THR 163 109, .595 19. .718 5. .790 1. .00 38, .40 1SG1268
ATOM 1268 CA THR 163 109. .013 19, .288 4. .554 1. .00 38, .40 1SG1269
ATOM 1269 CB THR 163 107. .527 19, .467 4, .514 1. .00 38, .40 1SG1270 > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > β ι-3 H ι-- H ι^ H ^ H H H ι-- H >-_ H H H H H H H H H ι-- H H H H H H H H ^ H H H H H H H H H H H H H H H H H ι-. H H H H H ι-3 o p o d d d d d p p p p p p p d p p p p p p p d d d d p p p p p p p p p p p p p d d d p p p p p p p p d d d d d d
2 3 2 3 3 2 2 2 2 2 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H W Ul UI W UJ W UI l UI UJ I UI UI UJ UJ UI Ul tO tO tO tO tO tO tO tO tO tO tO tO tO tO to to to t to to to to to to to to to to to to H H H H H H H O O O O O O O O O O VD VD VD VD V0 V0 V0 VD VD VD 00 C0 CD 00 OO OO OO OO OO OO ^l -J -J -J -J -J -J -J -J -J oι uι * u κι μ o ιo o) o σι _i ιt* u tθ H θ vo oo ^ι en ui ιt* uι tθ H θ vD θD - cn -i ιt* uι tθ H θ vo oo -j -i ui * u) tθ H θ vo oo -j σι ui ιt* ω tθ H θ
P Ω Ω Ω Ω Ω Ω 3 P ΩPP Ω Ω Ωa P Ω Ω Ω Ω Ω Ω a P Ω P Ω Ω Ω Ω Ω Ω Ω Ω 3 P Ω g O Ω Ω Ω a P Ω d d Ω Ω Ω a d Ω Ω P d d Ω ro d d Ω ω > d d Ω ω > κ tsι t. ro d d Ω ro > d Ω ro > M M d Ω ro Ω Ω
H tO to H H to to H to tO H tO H to H CH CH CH CH CH CH CH ι -^ CH CH CH H C-| -, H H ι-3 ι-- H H H H H β H H > > Ω Ω Ω Ω Ω Ω Ω Ω Ω H H H H M M M M M M M M Cn M O- W Cn cn CΩ CD M M M H M M M M α α α α α α α Q D3 D3 j >β 'd O O >α c c α c α α α c! w w w w
H H H , . , H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H σi cn cn en en cn cn cn cn cn cn n σi σi σi σi σi σi en cn cn en cn σ m σi σ σi in σi σi σ σi σi σi σi σi cn cn cn σi σi σi σi σi σi σi σ σi σi σi σi en cn cn
-" ~ " ~ ω oo co o o -j o o o -ι o oι oι oι oi (iι oι ιι trι oι m oι oι uι uι uι ιn uι uι uι ιπ ** * ^ ιfι ^ A ^ ** * ι ω ω ω
H H H H H H H O O O H O O O i- iD Cθ o ιo o o * w o) θi uι iD μ to o oo -j VD H Vo
Figure imgf000488_0001
H ∞ -J to ui ιt* -i w w w w ι M io w w w w w M w ω w ιo w ιo w u w w w w w μ w ι. ι. w ιo u w ιo u u ιo ιo ιo to w ι ω (o (j μ μ μ μ NJ W W K) t- H io
H O W W M KJ H H O H O O O H H UI M H UI UI Ul U UI tO W VD O O H H tO tO if* it* J Ul it* Cn -J -l it* it* tO tO tO -J VD OO lO O O O O O OO O
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O lD O H VO H O CD W CD VD On in H VD 01 01 tO ^ J O tO O J J if* H if* lD _l J -1 01 01 0 Ul H en H t0 ^ ^ it* _J O H _3 VD VO Ul -1 0 W H VO On tO
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0 00 -J H -l lD -l -l Ul Ul VD VD lD _- _J ιt* ιt* H -0 -1 0 t0 ^ ιt Ul _l U1 0 ιt* VD ω UI CD H ^ -J ω H VD VO H UI UI O O ιt* -j ω ιl* O O H VD Ul UJ -j ω O H W tO VD tO Cn it* it* O H -l H tO VO U> it> H tO lD H OO VD W -J J Ul it* VO it* NJ U1 0 VD UI i^ -1 0 -l U1 0 t0 ^ m -J it* H H VD UI UI 01 UI VD OO U1 00
H H H H H H H H H H H H H H H o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o uι uι u) w ω w w w uι uι ι*J U U Ui ω ω uι uι _ι -i uι uι uι uι ui -i uι ui (n ιn ui -i -i uι uι uJ uι uι uι uι uι u) iΛJ o o o o o o o o o oo oo cn cn en cn cn in cn oi co eD Oo cD CD CD Co oo -i -i -i ui ui ui ui ui uJ U) W J Ui ui u> ui _j _J ) w to to to to to to to to ui ui ui ui ui m ui ui ui m ui ui ui ui ui ui -J -J -J -j -j -j -j -j ^i -j -j ^i
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H
CQ _ _ι cn cn cD _ι CD w ω w cn w -i -i W - - -i -i -i -ι - - ω _i -i _ w cD CD _ι _ι - _i -3 _ι _ι CD - ω _ι _ι _ι ω cn _ι ω ΏΏΏ Ω Ω Ω ΩΩΩ ΩΏ Ω ΩΩ ΩΩ ΩΩΏ ΩΩ ΩΩΩΩΩ ΩΩΩ Ω Ω Ω Ω Ω ΩΩΩΩΩ ΩΩ ΩΩΩΩΩ ΩΩΩ Ώ ΩΩΩΩ ΩΩΩ
H H t-y t- H t-y t-y t-y H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H to to to to to to to to to to to to to to to to to to to to to to to to to io to to to tO tO tO tO t IO tO tO H H H H H H H H H O O O O O O O O O O j oι ιn ιi* w w μ o iD ω -o (iι ιn *' U i μ o iD iB j oι ιn * w _ μ o ιo eθ i oι ui ιi* w ιo μ o iD iιι ^ oι oι * w (o μ o iD i)o ι o ui ιtι w w μ
ATOM 1327 N ASN 170 103.,744 19..661 15.788 1.,00 42..33 1SG1328
ATOM 1328 CA ASN 170 102. ,495 19. .103 16. ,236 1. .00 42. .33 1SG1329
ATOM 1329 CB ASN 170 102. ,408 17. .574 16. ,054 1. .00 42. ,33 1SG1330
ATOM 1330 CG ASN 170 102. .364 17. .230 14. ,576 1. .00 42. ,33 1SG1331
ATOM 1331 ODl ASN 170 101. .466 17. .659 13. .854 1. ,00 42. ,33 1SG1332
ATOM 1332 ND2 ASN 170 103. .357 16. .428 14. .108 1. .00 42. .33 1SG1333
ATOM 1333 C ASN 170 102. .397 19, .312 17. .718 1. .00 42. .33 1SG1334
ATOM 1334 0 ASN 170 103. .323 18, .977 18. .457 1. .00 42. .33 1SG1335
ATOM 1335 N LEU 171 101, .263 19. .872 18. .192 1. .00 43. .36 1SG1336
ATOM 1336 CA LEU 171 101, .075 20. .069 19. .608 1. .00 43. .36 1SG1337
ATOM 1337 CB LEU 171 100, .949 21, .538 20. .039 1, .00 43. .36 1SG1338
ATOM 1338 CG LEU 171 102. .184 22, .404 19. .746 1. .00 43. .36 1SG1339
ATOM 1339 CD2 LEU 171 102. .045 23. .785 20. ,407 1. .00 43. .36 1SG1340
ATOM 1340 CDl LEU 171 102. .454 22. .492 18. ,236 1. .00 43. .36 1SG1341
ATOM 1341 C LEU 171 99. .784 19. .410 20. .005 1. .00 43. .36 1SG1342
ATOM 1342 0 LEU 171 98. .901 19. .209 19. .172 1. .00 43. .36 1SG1343
ATOM 1343 N LYS 172 99. .652 19. .027 21. .296 1. .00 46. .38 1SG1344
ATOM 1344 CA LYS 172 98, .460 18. .371 21. .773 1. .00 46. .38 1SG1345
ATOM 1345 CB LYS 172 98, .598 17, .805 23. .196 1, .00 46. .38 1SG1346
ATOM 1346 CG LYS 172 99, .607 16, .656 23. .237 1, .00 46. .38 1SG1347
ATOM 1347 CD LYS 172 99, .909 16, .095 24. .625 1, .00 46. .38 1SG1348
ATOM 1348 CE LYS 172 99, .882 17, .142 25. .732 1. .00 46, .38 1SG1349
ATOM 1349 NZ LYS 172 98, .627 16, .994 26. .501 1. .00 46. .38 1SG1350
ATOM 1350 C LYS 172 97, .266 19 .287 21, .718 1. .00 46 .38 1SG1351
ATOM 1351 0 LYS 172 96 .216 18 .905 21, .202 1. .00 46 .38 1SG1352
ATOM 1352 N GLY 173 97 .390 20 .524 22, .237 1. .00 51 .85 1SG1353
ATOM 1353 CA GLY 173 96 .332 21 .496 22, .130 1 .00 51 .85 1SG1354
ATOM 1354 C GLY 173 95, .056 21, .059 22. .794 1. .00 51. .85 1SG1355
ATOM 1355 0 GLY 173 94, .035 20, .878 22. .127 1. .00 51. .85 1SG1356
ATOM 1356 N VAL 174 95, .072 20, .856 24. .126 1, .00 59. .42 1SG1357
ATOM 1357 CA VAL 174 93, .846 20, .547 24. .805 1. .00 59, .42 1SG1358
ATOM 1358 CB VAL 174 93, .713 19, .087 25. .129 1. .00 59, .42 1SG1359
ATOM 1359 CGI VAL 174 92, .445 18 .880 25. .974 1. .00 59, .42 1SG1360
ATOM 1360 CG2 VAL 174 93, .734 18 .289 23. .814 1. .00 59, .42 1SG1361
ATOM 1361 C VAL 174 93, .850 21 .288 26. .110 1. .00 59, .42 1SG1362
ATOM 1362 0 VAL 174 94. .869 21 .326 26, .801 1. .00 59, .42 1SG1363
ATOM 1363 N PHE 175 92, .698 21 .892 26, .479 1. .00 66 .78 1SG1364
ATOM 1364 CA PHE 175 92 .568 22 .535 27, .760 1. .00 66 .78 1SG1365
ATOM 1365 CB PHE 175 91 .261 23 .329 27, .943 1, .00 66, .78 1SG1366
ATOM 1366 CG PHE 175 91 .425 24 .720 27, .426 1 .00 66 .78 1SG1367
ATOM 1367 CDl PHE 175 91 .533 24 .993 26, .080 1, .00 66 .78 1SG1368
ATOM 1368 CD2 PHE 175 91 .443 25 .769 28, .321 1, .00 66 .78 1SG1369
ATOM 1369 CE1 PHE 175 91, .674 26, .291 25. .644 1. .00 66. .78 1SG1370
ATOM 1370 CE2 PHE 175 91, .583 27, .066 27. .888 1. .00 66. .78 1SG1371
ATOM 1371 CZ PHE 175 91, .697 27, .327 26. .546 1. .00 66, .78 1SG1372
ATOM 1372 C PHE 175 92, .584 21, .427 28. .757 1. .00 66. .78 1SG1373
ATOM 1373 0 PHE 175 92, .096 20, .330 28. .494 1. .00 66. .78 1SG1374
ATOM 1374 N TYR 176 93, .176 21, .713 29. .926 1. .00 70. .44 1SG1375
ATOM 1375 CA TYR 176 93, .553 20 .704 30, .865 1. .00 70. .44 1SG1376
ATOM 1376 CB TYR 176 95, .075 20 .803 30, .744 1. .00 70, .44 1SG1377
ATOM 1377 CG TYR 176 95, .898 19, .716 31, .279 1. .00 70, .44 1SG1378
ATOM 1378 CDl TYR 176 95 .663 18 .417 30, .918 1. .00 70. .44 1SG1379
ATOM 1379 CD2 TYR 176 96, .974 20 .033 32. .065 1. .00 70. .44 1SG1380
ATOM 1380 CE1 TYR 176 96 .487 17 .432 31. .398 1. .00 70. .44 1SG1381
ATOM 1381 CE2 TYR 176 97 .802 19 .051 32, .541 1. .00 70. .44 1SG1382
ATOM 1382 CZ TYR 176 97 .554 17 .743 32, .206 1. .00 70. .44 1SG1383
ATOM 1383 OH TYR 176 98 .400 16 .722 32, .685 1. .00 70, .44 1SG1384 ATOM 1384 C TYR 176 93..107 21.,125 32..238 1.,00 70..44 1SG1385
ATOM 1385 O TYR 176 93. .250 22. .289 32. .603 1. .00 70. .44 1SG1386
ATOM 1386 N PRO 177 92. .461 20. .255 32. .967 1. .00 64. .81 1SG1387
ATOM 1387 CA PRO 177 92. .164 20. .590 34. .343 1. .00 64. .81 1SG1388
ATOM 1388 CD PRO 177 91. .357 19. .555 32. .334 1. .00 64. .81 1SG1389
ATOM 1389 CB PRO 177 90. .733 20. .112 34. .603 1, .00 64. .81 1SG1390
ATOM 1390 CG PRO 177 90. .464 19. .086 33, .488 1. .00 64. .81 1SG1391
ATOM 1391 C PRO 177 93, .163 20. .003 35, .302 1. .00 64. .81 1SG1392
ATOM 1392 O PRO 177 93. .507 18. .833 35 .142 1. .00 64. .81 1SG1393
ATOM 1393 N LEU 178 93. .635 20. .776 36, .307 1. .00 57. .39 1SG1394
ATOM 1394 CA LEU 178 94. ,509 20. .255 37, .329 1. .00 57. .39 1SG1395
ATOM 1395 CB LEU 178 95. .174 21. ,351 38. .186 1. ,00 57, .39 1SG1396
ATOM 1396 CG LEU 178 96. .323 22. .135 37. .523 1. .00 57. .39 1SG1397
ATOM 1397 CD2 LEU 178 95. .907 22. .669 36. .143 1. ,00 57, .39 1SG1398
ATOM 1398 CDl LEU 178 97. .621 21. ,309 37. .477 1. .00 57, .39 1SG1399
ATOM 1399 C LEU 178 93. .745 19. .412 38, .308 1. .00 57. .39 1SG1400
ATOM 1400 0 LEU 178 94. .160 18. .305 38 .652 1. .00 57, .39 1SG1401
ATOM 1401 N GLU 179 92, .596 19. .931 38, .795 1. .00 49, .66 1SG1402
ATOM 1402 CA GLU 179 91. .914 19. .250 39 .857 1. .00 49, .66 1SG1403
ATOM 1403 CB GLU 179 90. .801 20. .069 40, .535 1. .00 49. .66 1SG1404
ATOM 1404 CG GLU 179 91. .399 21. .085 41, .516 1. .00 49, .66 1SG1405
ATOM 1405 CD GLU 179 90, .287 21. .779 42 .288 1. .00 49, .66 1SG1406
ATOM 1406 OEl GLU 179 89, .443 21. .066 42, .893 1, .00 49 .66 1SG1407
ATOM 1407 OE2 GLU 179 90. .273 23. .039 42 .287 1. .00 49, .66 1SG1408
ATOM 1408 C GLU 179 91, .405 17. .919 39, .427 1. .00 49 .66 1SG1409
ATOM 1409 O GLU 179 91, .579 16. .944 40 .155 1, .00 49, .66 1SG1410
ATOM 1410 N ASN 180 90, .762 17. .809 38, .253 1. .00 44 .49 1SG1411
ATOM 1411 CA ASN 180 90, ,429 16. .470 37 .871 1. .00 44, .49 1SG1412
ATOM 1412 CB ASN 180 89 .027 15, .960 38, .277 1. .00 44 .49 1SG1413
ATOM 1413 CG ASN 180 87, .912 16, .723 37 .588 1. .00 44 .49 1SG1414
ATOM 1414 ODl ASN 180 87 .999 17, .924 37 .339 1. .00 44 .49 1SG1415
ATOM 1415 ND2 ASN 180 86, .805 15, .992 37 .285 1. .00 44 .49 1SG1416
ATOM 1416 C ASN 180 90 .653 16, .343 36 .406 1. .00 44 .49 1SG1417
ATOM 1417 O ASN 180 90, .401 17, .268 35 .637 1. .00 44 .49 1SG1418
ATOM 1418 N LEU 181 91 .166 15, .170 35, .999 1. .00 48 .20 1SG1419
ATOM 1419 CA LEU 181 91, .569 14, .905 34 .653 1. .00 48 .20 1SG1420
ATOM 1420 CB LEU 181 92 .816 13 .999 34 .666 1. .00 48 .20 1SG1421
ATOM 1421 CG LEU 181 93 .460 13, .646 33 .317 1. .00 48 .20 1SG1422
ATOM 1422 CD2 LEU 181 94 .424 12 .454 33, .474 1, .00 48 .20 1SG1423
ATOM 1423 CDl LEU 181 94 .137 14, .877 32 .693 1. .00 48 .20 1SG1424
ATOM 1424 C LEU 181 90 .471 14 .137 33 .991 1. .00 48, .20 1SG1425
ATOM 1425 O LEU 181 90 .069 13 .077 34 .467 1, .00 48 .20 1SG1426
ATOM 1426 N THR 182 89 .925 14 .666 32 .880 1, .00 54, .39 1SG1427
ATOM 1427 CA THR 182 88 .954 13 .882 32 .184 1, .00 54 .39 1SG1428
ATOM 1428 CB THR 182 87 .572 13 .938 32 .781 1, .00 54, .39 1SG1429
ATOM 1429 OGl THR 182 86 .639 13, .232 31 .976 1 .00 54 .39 1SG1430
ATOM 1430 CG2 THR 182 87 .160 15 .389 33 .030 1, .00 54, .39 1SG1431
ATOM 1431 C THR 182 89 .021 14 .193 30 .718 1 .00 54 .39 1SG1432
ATOM 1432 O THR 182 89 .162 15 .340 30 .299 1, .00 54, .39 1SG1433
ATOM 1433 N ASP 183 88 .955 13 .118 29 .907 1, .00 67 .65 1SG1434
ATOM 1434 CA ASP 183 89 .163 13 .146 28 .483 1 .00 67 .65 1SG1435
ATOM 1435 CB ASP 183 89 .277 11 .736 27 .886 1, .00 67 .65 1SG1436
ATOM 1436 CG ASP 183 90 .407 11, .006 28 .582 1, .00 67, .65 1SG1437
ATOM 1437 ODl ASP 183 91 .312 11 .695 29 .124 1, .00 67, .65 1SG1438
ATOM 1438 OD2 ASP 183 90 .371 9 .748 28 .596 1, .00 67 .65 1SG1439
ATOM 1439 C ASP 183 87 .995 13 .744 27 .771 1, .00 67, .65 1SG1440
ATOM 1440 O ASP 183 86, .851 13, .691 28, .227 1. .00 67. .65 1SG1441 ATOM 1441 N PRO 184 88..307 14..353 26..655 1..00 81..20 1SG1442
ATOM 1442 CA PRO 184 87. .292 14. .808 25. .746 1. ,00 81. .20 1SG1443
ATOM 1443 CD PRO 184 89. .509 15. .165 26. .569 1. ,00 81. ,20 1SG1444
ATOM 1444 CB PRO 184 87. .921 15. .923 24. .903 1. ,00 81. .20 1SG1445
ATOM 1445 CG PRO 184 89. .432 15. .803 25. .175 1. .00 81. .20 1SG1446
ATOM 1446 C PRO 184 86, .862 13. .609 24. .954 1. ,00 81. ,20 1SG1447
ATOM 1447 O PRO 184 87, .727 12, .787 24. .655 1. ,00 81. .20 1SG1448
ATOM 1448 N PRO 185 85, .621 13. .464 24. .582 1. .00 88. .36 1SG1449
ATOM 1449 CA PRO 185 85 .152 12. .303 23. .864 1. .00 88. .36 1SG1450
ATOM 1450 CD PRO 185 84, .717 14. .587 24. .412 1. .00 88. .36 1SG1451
ATOM 1451 CB PRO 185 83, .656 12. .499 23. .733 1. .00 88. .36 1SG1452
ATOM 1452 CG PRO 185 83 .555 14 , .026 23. .565 1. .00 88. .36 1SG1453
ATOM 1453 C PRO 185 85 .754 12. .312 22. .489 1. .00 88. .36 1SG1454
ATOM 1454 O PRO 185 85, .549 11. .378 21. .709 1. .00 88. .36 1SG1455
ATOM 1455 N PHE 186 86, .444 13, .411 22 , .193 1. .00 90. .51 1SG1456
ATOM 1456 CA PHE 186 87 .006 13. .856 20. .961 1. .00 90. .51 1SG1457
ATOM 1457 CB PHE 186 87. .630 15. .232 21. .088 1. .00 90. .51 1SG1458
ATOM 1458 CG PHE 186 86, .588 16, .225 20, .956 1. .00 90. .51 1SG1459
ATOM 1459 CDl PHE 186 86 .240 16, .579 19, .688 1. .00 90. .51 1SG1460
ATOM 1460 CD2 PHE 186 85 .978 16 .767 22 .049 1, .00 90. .51 1SG1461
ATOM 1461 CE1 PHE 186 85, .268 17, .514 19, .482 1. ,00 90. .51 1SG1462
ATOM 1462 CE2 PHE 186 85 .005 17, .706 21, .843 1. .00 90, .51 1SG1463
ATOM 1463 CZ PHE 186 84 .651 18, .078 20 .569 1. .00 90, .51 1SG1464
ATOM 1464 C PHE 186 88 .212 13 .204 20 .440 1. .00 90, .51 1SG1465
ATOM 1465 O PHE 186 89, .102 12 , .744 21, .151 1. .00 90, .51 1SG1466
ATOM 1466 N SER 187 88 .265 13, .345 19. .101 1. .00 78, .04 1SG1467
ATOM 1467 CA SER 187 89 .382 13, .075 18 .269 1. .00 78, .04 1SG1468
ATOM 1468 CB SER 187 89 .090 12 .022 17 .189 1, .00 78, .04 1SG1469
ATOM 1469 OG SER 187 88, .761 10, .780 17, .790 1. .00 78, .04 1SG1470
ATOM 1470 C SER 187 89, .606 14, .376 17, .546 1. .00 78. .04 1SG1471
ATOM 1471 O SER 187 88 .656 15, .015 17 .090 1, .00 78, .04 1SG1472
ATOM 1472 N PRO 188 90 .837 14 .801 17 .473 1. .00 67, .60 1SG1473
ATOM 1473 CA PRO 188 91, .158 16 , .021 16, .775 1. .00 67. .60 1SG1474
ATOM 1474 CD PRO 188 91. .720 14, .575 18, .610 1. .00 67, .60 1SG1475
ATOM 1475 CB PRO 188 92 .581 16, .373 17 .214 1. .00 67, .60 1SG1476
ATOM 1476 CG PRO 188 92. .688 15, .769 18, .628 1. .00 67. .60 1SG1477
ATOM 1477 C PRO 188 91. .005 15, .824 15, .297 1. .00 67. .60 1SG1478
ATOM 1478 O PRO 188 91, .201 14, .706 14 .824 1. .00 67. .60 1SG1479
ATOM 1479 N VAL 189 90 .650 16, .895 14 .558 1. .00 60. .66 1SG1480
ATOM 1480 CA VAL 189 90, .431 16. .828 13 , .140 1. .00 60. .66 1SG1481
ATOM 1481 CB VAL 189 89, .630 17. .994 12, .632 1. .00 60. .66 1SG1482
ATOM 1482 CGI VAL 189 89, .608 17, .970 11, .094 1. .00 60. .66 1SG1483
ATOM 1483 CG2 VAL 189 88 .237 17, .944 13, .284 1, .00 60, .66 1SG1484
ATOM 1484 C VAL 189 91, .745 16, .843 12, .434 1. .00 60. .66 1SG1485
ATOM 1485 O VAL 189 92, .748 17, .361 12, .929 1. .00 60. .66 1SG1486
ATOM 1486 N PRO 190 91, .745 16, .205 11, .293 1. .00 59. .08 1SG1487
ATOM 1487 CA PRO 190 92 .873 16, .207 10 .409 1. .00 59. .08 1SG1488
ATOM 1488 CD PRO 190 90, .784 15. .163 10, .974 1. .00 59. .08 1SG1489
ATOM 1489 CB PRO 190 92, .526 15. .225 9, .285 1. .00 59. .08 1SG1490
ATOM 1490 CG PRO 190 91, .024 14. .911 9 .477 1. .00 59. .08 1SG1491
ATOM 1491 C PRO 190 93, .028 17. .623 9, .986 1. ,00 59. ,08 1SG1492
ATOM 1492 O PRO 190 92, .083 18. .192 9, .447 1. ,00 59. ,08 1SG1493
ATOM 1493 N PHE 191 94, .225 18, .185 10, .197 1. .00 64. ,11 1SG1494
ATOM 1494 CA PHE 191 94, .401 19, .589 10, .053 1. .00 64. .11 1SG1495
ATOM 1495 CB PHE 191 95. .169 20. .003 11. .297 1. ,00 64. .11 1SG1496
ATOM 1496 CG PHE 191 94. .693 21. .302 11. .728 1. ,00 64. ,11 1SG1497
ATOM 1497 CDl PHE 191 95, .130 22. .431 11, .106 1. .00 64. .11 1SG1498 H H H ^ H H H ^ ^ H H H H H ^ H H H H H H 4 H H ι-_ H H H ι-. H H β H H H H H ^ H ι-- ^ μ. H H H ^ '-3 H H H H H r. H H H o o o o o o o d d O d o o o o o p o P O d o o p d d P d d o o p d d d d d P O P d O d d d d O P P P p p p p d d d
22 23 32 S 3322 222 Ξ 2222 3 332333 32222 2 22 2 2222 2232223 22232222322
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Ω Ω a o Ω P Ω Ω a o Ω Ω Ω Ω Ω Ω OΩOPΩΩΩΩ2 P Ω Ω Ω Ω Ω a PΩΩΩΩΩΩΪϋPΩΩΩΩΩa P Ω Ω Ω Ω Ω ro > Ω ro > N M d Ω ro > W H d Ω d > Ω W d > d d Ω « > Ώ Ω to H H t tO H ω N W M d t H to ; w w w oι w w > ; ;y:iH ;>;> ;μ ;> Ω Ω Ω Ω Ω Ω θΩΩ O O d^ _« _< _^ -^
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H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H
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H H H H H H H H H H H H H H H H H H H H H H H
O O O O O O O O O O O VD VO VO VD VO O O O O O O O O O O O O VO VD VD VO VD VO VO VO VO VO VD VO VD VD VD VD VO VO VD VD VD VO VO VD VD VO VD VD VO o w ι ι. w ιn ιn ^ w ω w w <!i ιιi vi oι o o μ μ o μ * * w i W θ oo (D in ι_ * Ni oι o oi i (jι o ιn ιn ιn ιi* _ ιn -ι oι ιn *' θi uι w u ιl* u i ι Λ i_ ιo -j * M o μ oι * _ ιi> o »ι o μ M co o μ w oι u μ i- oι U ιi* μ * ιo w w oι oι ιi) U * w « iD U W μ w u (iι co uι ι j w oι ιιι μ (* * H U «) U ιi> i ιo μ -i ιi* j α) -ι iϋ m i ιo ι μ iD ω cn uι W (D <ji vi m o o) o ιn U -ι μ ιo <> iJi cιι oι co .j iD μ μ μ iJ i* o w uι μ * o «i M io μ oι ιi (iι * iιi ι o ttι oι μ ιo H U i ιιι w o u ιo H i/ι ω ιo oι o oι μ u oι ιjι * μ oι o μ iιi o oι cn o ιιι u u w i u j ^ ιιι p ^ oι u
UI UI UI UI Ul UI U> UJ UJ tO U> U) UI Ul w uJ to to to to to to to to to to to to to to tJ to to to to to to to to to to to to to Ul _l _- ιt* _- O H H H VO O O tO H to o cn H uι uι ^ oo H ^ H m t ιt* ιt* eJ σι ι^ H H H -j ιn uι -j vo oo to ^] ^ι ι θ H H -j to oo oo -i H oo uι U' H t H H iθ H -J θ oo σι _ι en ιo μ u _ oι ι * μ iΛ ^ o w oι ** -ι ιo oι μ ιn ιn ιo ιιι o iJi W (B ^ o * ιi* ^ oι w iD θι iD w ^ w t ^ ιJ ιι ιtι * ιo θ vi w co iD U Uι ι ι u
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-l W _l CD Cn CD _l CD C0 CD CD W _l -l Crj _l -l _l -l W _l CD _l CD _l -l _l _1 01 tn tn in oi tn oi ffl w in tn oi ra m oi w in in oi oi ω oi M ϋi w oi ω oi
Ώ Ω Ώ Ώ Ώ Ώ Ω Ώ Ώ Ώ Ώ Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ Ώ Ώ Ω Ώ Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ Ω Ω
H H H H H H H H H H H H H H H H H H H H H ui ui ui ui ui in in in ui ui ui ui ui ui in -i in ui ui in -i ui ui in ui ui ui ui ui ui ui ui ui ui ui ui in in ui in ui ui ui in in ui in in ui ui ui w
Ul Ul Ul Ul Ul ln ιf* ιt* ι^ ιf* ιlv. ιf* ιl- ιt* ιl* ιl* w ω lJ l _J ω ω W J -J t - tO tO M t tO tO t M H H H H H H H H H H O O O O O O θ σ θ O VO ui ιf* uι tθ H θ iD ∞ -j σι ui ιt* w tθ H θ o oo -j σι ui ιt* uJ to O lD 00 -J 01 Ul it* -- t0 H O VD 03 -0 -l Ul it* U t0 H O lD 00 -J _l Ul il* Ul t0 H O V0
ATOM 1555 CG ASN 198 100..291 34..854 1..523 1..00 33..72 1SG1556
ATOM 1556 ODl ASN 198 100. .963 34. .083 0. .840 1. 00 33. .72 1SG1557
ATOM 1557 ND2 ASN 198 99 . .139 35. .416 1. ,068 1. 00 33. .72 1SG1558
ATOM 1558 C ASN 198 102. .723 35. .560 4, .328 1. .00 33, .72 1SG1559
ATOM 1559 0 ASN 198 103, .171 36. .702 4. .422 1. .00 33, .72 1SG1560
ATOM 1560 N SER 199 102. .635 34. .730 5. .387 1. .00 35, .19 1SG1561
ATOM 1561 CA SER 199 103. .046 35, .150 6. .697 1. ,00 35, .19 1SG1562
ATOM 1562 CB SER 199 101. .913 35, .168 7, .732 1. .00 35 .19 1SG1563
ATOM 1563 OG SER 199 100. .926 36, .119 7. .360 1. ,00 35, .19 1SG1564
ATOM 1564 C SER 199 104. .071 34. .172 7. .177 1. .00 35. .19 1SG1565
ATOM 1565 0 SER 199 104. .280 33, .125 6, .567 1. .00 35, .19 1SG1566
ATOM 1566 N MET 200 104. .800 34. .543 8. .248 1. .00 37 .60 1SG1567
ATOM 1567 CA MET 200 105, .852 33. .717 8. .768 1. .00 37, .60 1SG1568
ATOM 1568 CB MET 200 106, .707 34. .454 9. .811 1. .00 37 .60 1SG1569
ATOM 1569 CG MET 200 107, .504 35, .608 9. .197 1. ,00 37, .60 1SG1570
ATOM 1570 SD MET 200 108. .545 36. .537 10. .360 1. ,00 37, .60 1SG1571
ATOM 1571 CE MET 200 109 .214 37 .652 9 .092 1. .00 37 .60 1SG1572
ATOM 1572 C MET 200 105. .346 32. .443 9. .387 1. .00 37 .60 1SG1573
ATOM 1573 0 MET 200 105, .869 31. .368 9, .095 1. ,00 37, .60 1SG1574
ATOM 1574 N LEU 201 104, .307 32. .509 10. .248 1. .00 41 .16 1SG1575
ATOM 1575 CA LEU 201 103 .887 31 .316 10 .938 1. .00 41 .16 1SG1576
ATOM 1576 CB LEU 201 104, .187 31. .377 12 , .445 1. .00 41 .16 1SG1577
ATOM 1577 CG LEU 201 103, .803 30. .103 13. .215 1. ,00 41, .16 1SG1578
ATOM 1578 CD2 LEU 201 103, .834 30, .340 14. .734 1. .00 41 .16 1SG1579
ATOM 1579 CDl LEU 201 104 .672 28 .914 12 .777 1. .00 41 .16 1SG1580
ATOM 1580 C LEU 201 102, .405 31, .144 10. .781 1. .00 41 .16 1SG1581
ATOM 1581 0 LEU 201 101 .680 32 .110 10 .555 1, .00 41 .16 1SG1582
ATOM 1582 N TYR 202 101, .924 29, .882 10, .871 1. .00 43 .63 1SG1583
ATOM 1583 CA TYR 202 100, .518 29, .595 10 .771 1. .00 43 .63 1SG1584
ATOM 1584 CB TYR 202 100 .123 28 .833 9 .492 1. .00 43 .63 1SG1585
ATOM 1585 CG TYR 202 100 .293 29 .689 8 .283 1. .00 43 .63 1SG1586
ATOM 1586 CDl TYR 202 101, .544 29, .987 7, .794 1. .00 43 .63 1SG1587
ATOM 1587 CD2 TYR 202 99, .188 30 .167 7 .615 1. .00 43 .63 1SG1588
ATOM 1588 CE1 TYR 202 101 .689 30 .766 6 .670 1, .00 43 .63 1SG1589
ATOM 1589 CE2 TYR 202 99, .326 30, .946 6 .491 1. .00 43 .63 1SG1590
ATOM 1590 CZ TYR 202 100, .580 31, .248 6, .018 1. .00 43 .63 1SG1591
ATOM 1591 OH TYR 202 100, .730 32, .046 4, .864 1, .00 43 .63 1SG1592
ATOM 1592 C TYR 202 100 .153 28 .667 11 .890 1, .00 43 .63 1SG1593
ATOM 1593 O TYR 202 100, .868 27, .703 12, .161 1. .00 43 .63 1SG1594
ATOM 1594 N ILE 203 99 .013 28, .920 12 .568 1. .00 44 .61 1SG1595
ATOM 1595 CA ILE 203 98, .619 28, .000 13, .593 1. .00 44 .61 1SG1596
ATOM 1596 CB ILE 203 98 .589 28, .543 15 .000 1. .00 44 .61 1SG1597
ATOM 1597 CG2 ILE 203 99 .998 29 .056 15 .340 1. .00 44 .61 1SG1598
ATOM 1598 CGI ILE 203 97, .495 29, .604 15, .186 1. .00 44 .61 1SG1599
ATOM 1599 CDl ILE 203 97, .206 29, .909 16, .657 1. .00 44, .61 1SG1600
ATOM 1600 C ILE 203 97 .246 27 .535 13 .271 1. .00 4 .61 1SG1601
ATOM 1601 0 ILE 203 96 .406 28, .288 12 .778 1. .00 44 .61 1SG1602
ATOM 1602 N GLY 204 96, .994 26, .244 13, .520 1. .00 44, .47 1SG1603
ATOM 1603 CA GLY 204 95, .690 25, .756 13 .249 1. .00 44, .47 1SG1604
ATOM 1604 C GLY 204 95, .095 25, .366 14 .557 1, .00 44 .47 1SG1605
ATOM 1605 0 GLY 204 95 .519 24, .392 15 .181 1. .00 44 .47 1SG1606
ATOM 1606 N ILE 205 94. .049 26, .103 14, .972 1. .00 48, .07 1SG1607
ATOM 1607 CA ILE 205 93 .415 25, .799 16, .215 1. .00 48, .07 1SG1608
ATOM 1608 CB ILE 205 93, .124 27. .033 17, .048 1. ,00 48, .07 1SG1609
ATOM 1609 CG2 ILE 205 92, .180 27, .958 16, .263 1. .00 48, .07 1SG1610
ATOM 1610 CGI ILE 205 92 .640 26, .676 18 .464 1. .00 48 .07 1SG1611
ATOM 1611 CDl ILE 205 91, .253 26. .043 18, .524 1. .00 48, .07 1SG1612 ATOM 1612 C ILE 205 92..160 25..036 15.,904 1.00 48..07 1SG1613
ATOM 1613 O ILE 205 91. .193 25. .569 15. .368 1. ,00 48. .07 1SG1614
ATOM 1614 N ALA 206 92. .159 23, .731 16. .237 1. ,00 50. .23 1SG1615
ATOM 1615 CA ALA 206 91. .077 22, .834 15. .924 1. .00 50. .23 1SG1616
ATOM 1616 CB ALA 206 91. .470 21, .353 16. .058 1. .00 50. .23 1SG1617
ATOM 1617 C ALA 206 89, .886 23, .066 16. .814 1. .00 50. .23 1SG1618
ATOM 1618 0 ALA 206 89, .988 23, .707 17. .856 1. .00 50. .23 1SG1619
ATOM 1619 N GLU 207 88, .714 22 .525 16, .401 1. .00 54. .67 1SG1620
ATOM 1620 CA GLU 207 87, .472 22, .645 17. .126 1. .00 54. .67 1SG1621
ATOM 1621 CB GLU 207 86, .353 21, .693 16. .666 1, .00 54, .67 1SG1622
ATOM 1622 CG GLU 207 85, .655 21 .887 15. .329 1, .00 54 .67 1SG1623
ATOM 1623 CD GLU 207 84. .584 20, .795 15. .316 1. .00 54, .67 1SG1624
ATOM 1624 OEl GLU 207 83. .679 20. .850 16. .189 1, .00 54, .67 1SG1625
ATOM 1625 OE2 GLU 207 84. .668 19, .878 14. .450 1. .00 54, .67 1SG1626
ATOM 1626 C GLU 207 87. .695 22, .044 18. .464 1. .00 54, . 61 1SG1627
ATOM 1627 O GLU 207 87. .216 22, .527 19. .488 1. .00 54, .67 1SG1628
ATOM 1628 N TYR 208 88. .428 20, .928 18. .443 1, .00 60 .62 1SG1629
ATOM 1629 CA TYR 208 88, .699 20, .104 19. .571 1. .00 60, .62 1SG1630
ATOM 1630 CB TYR 208 89, .595 18, .957 19, .071 1. .00 60, .62 1SG1631
ATOM 1631 CG TYR 208 90 .257 18 .202 20, .154 1. .00 60 .62 1SG1632
ATOM 1632 CDl TYR 208 89, .518 17 .490 21 .064 1, .00 60 .62 1SG1633
ATOM 1633 CD2 TYR 208 91, .630 18, .245 20, .273 1, .00 60 .62 1SG1634
ATOM 1634 CE1 TYR 208 90. .142 16, .785 22, .060 1, .00 60 .62 1SG1635
ATOM 1635 CE2 TYR 208 92 .260 17 .542 21 .268 1 .00 60 .62 1SG1636
ATOM 1636 CZ TYR 208 91 .515 16 .808 22 .161 1 .00 60 .62 1SG1637
ATOM 1637 OH TYR 208 92 .159 16 .080 23, .182 1, .00 60 .62 1SG1638
ATOM 1638 C TYR 208 89, .348 20, .954 20, .609 1. .00 60 .62 1SG1639
ATOM 1639 O TYR 208 88, .983 20, .924 21, .784 1. .00 60 .62 1SG1640
ATOM 1640 N PHE 209 90 .296 21 .790 20, .180 1. .00 60 .43 1SG1641
ATOM 1641 CA PHE 209 90, .996 22, .633 21, .089 1. .00 60 .43 1SG1642
ATOM 1642 CB PHE 209 92, .111 23, .362 20. .335 1, .00 60 .43 1SG1643
ATOM 1643 CG PHE 209 92 .876 24 .148 21. .322 1. .00 60 .43 1SG1644
ATOM 1644 CDl PHE 209 93 .464 23 .532 22 .402 1 .00 60 .43 1SG1645
ATOM 1645 CD2 PHE 209 93, .035 25, .493 21. .124 1 .00 60 .43 1SG1646
ATOM 1646 CE1 PHE 209 94, .184 24 .261 23. .308 1. .00 60 .43 1SG1647
ATOM 1647 CE2 PHE 209 93 .752 26 .236 22 .015 1. .00 60 .43 1SG1648
ATOM 1648 CZ PHE 209 94 .314 25 .609 2 .095 1 .00 60 .43 1SG1649
ATOM 1649 C PHE 209 90, .036 23 .582 21 .767 1 .00 60 .43 1ΞG1650
ATOM 1650 O PHE 209 90 .057 23 .723 22. .989 1. .00 60 .43 1SG1651
ATOM 1651 N PHE 210 89 .147 24 .245 21 .005 1, .00 59 .11 1SG1652
ATOM 1652 CA PHE 210 88 .186 25 .157 21 .579 1 .00 59 .11 1SG1653
ATOM 1653 CB PHE 210 87, .335 25 .926 20 .547 1, .00 59 .11 1SG1654
ATOM 1654 CG PHE 210 88, .065 27, .156 20, .137 1. .00 59, .11 1SG1655
ATOM 1655 CDl PHE 210 88, .166 28, .203 21, .022 1. .00 59, .11 1SG1656
ATOM 1656 CD2 PHE 210 88 .611 27 .294 18, .883 1. .00 59, .11 1SG1657
ATOM 1657 CE1 PHE 210 88 .828 29 .359 20, .671 1. .00 59 .11 1SG1658
ATOM 1658 CE2 PHE 210 89. .272 28, .451 18. .530 1. .00 59. .11 1SG1659
ATOM 1659 CZ PHE 210 89 .386 29, .486 19. .423 1, .00 59, .11 1SG1660
ATOM 1660 C PHE 210 87 .204 24 .434 22 .450 1, .00 59 .11 1SG1661
ATOM 1661 O PHE 210 86 .823 24 .938 23 .504 1. .00 59 .11 1SG1662
ATOM 1662 N LYS 211 86, .740 23, .247 22. .016 1. .00 53 .94 1SG1663
ATOM 1663 CA LYS 211 85 .721 22 .516 22. .718 1, .00 53, .94 1SG1664
ATOM 1664 CB LYS 211 85 .356 21 .206 22. .002 1, .00 53, .94 1SG1665
ATOM 1665 CG LYS 211 84 .201 20 .413 22. .618 1, .00 53, .94 1SG1666
ATOM 1666 CD LYS 211 82 .805 20 .832 22 .163 1, .00 53 .94 1SG1667
ATOM 1667 CE LYS 211 81 .740 19. .779 22. .492 1. .00 53. .94 1SG1668
ATOM 1668 NZ LYS 211 82, .087 18. .482 21. .861 1. .00 53. .94 1SG1669 ATOM 1669 C LYS 211 86..213 22..120 24.,073 1.,00 53..94 1SG1670
ATOM 1670 O LYS 211 85. .442 22. .103 25. .031 1. ,00 53. .94 1SG1671
ATOM 1671 N SER 212 87. ,508 21. ,768 24. .187 1. 00 46. .18 1SG1672
ATOM 1672 CA SER 212 88. .053 21. .296 25. .432 1. 00 46. ,18 1SG1673
ATOM 1673 CB SER 212 89. .563 21. .034 25. .354 1. ,00 46. .18 1SG1674
ATOM 1674 OG SER 212 89. .850 20. .192 24. .253 1. ,00 46. .18 1SG1675
ATOM 1675 C SER 212 87. .905 22. .363 26. .468 1. ,00 46. .18 1SG1676
ATOM 1676 O SER 212 87. .696 22. .073 27. .646 1, ,00 46. .18 1SG1677
ATOM 1677 N ALA 213 88. .035 23. .636 26. .057 1. ,00 39. .14 1SG1678
ATOM 1678 CA ALA 213 87. .966 24. .717 26. .996 1. .00 39, .14 1SG1679
ATOM 1679 CB ALA 213 88. .163 26. .089 26. .328 1. .00 39, .14 1SG1680
ATOM 1680 C ALA 213 86. .613 24. .735 27. .637 1. .00 39. .14 1SG1681
ATOM 1681 O ALA 213 86. .490 24. .867 28. .853 1. .00 39. .14 1SG1682
ATOM 1682 N SER 214 85. .556 24. .575 26. .822 1. .00 34. .43 1SG1683
ATOM 1683 CA SER 214 84. .201 24. .655 27. .287 1. .00 34, .43 1SG1684
ATOM 1684 CB SER 214 83. .197 24. .452 26. .134 1. .00 34, .43 1SG1685
ATOM 1685 OG SER 214 83. .371 25. .462 25. .149 1. .00 34. .43 1SG1686
ATOM 1686 C SER ' 214 83. .964 23. .578 28. .289 1. ,00 34. .43 1SG1687
ATOM 1687 O SER 214 83, .327 23, .796 29. .321 1. .00 34 .43 1SG1688
ATOM 1688 N PHE 215 84, .488 22 , .379 27. .998 1. .00 32, .99 1SG1689
ATOM 1689 CA PHE 215 84, .347 21, .226 28. .827 1. .00 32 .99 1SG1690
ATOM 1690 CB PHE 215 84, .967 20. .016 28. .116 1, .00 32, .99 1SG1691
ATOM 1691 CG PHE 215 85 .274 18. .981 29. .118 1. .00 32 .99 1SG1692
ATOM 1692 CDl PHE 215 84, .287 18. .206 29, .670 1. .00 32 .99 1SG1693
ATOM 1693 CD2 PHE 215 86, .579 18. .822 29, .511 1. .00 32 .99 1SG1694
ATOM 1694 CE1 PHE 215 84, .606 17. .253 30. .605 1. .00 32, .99 1SG1695
ATOM 1695 CE2 PHE 215 86, .904 17. .876 30. .445 1. .00 32, .99 1SG1696
ATOM 1696 CZ PHE 215 85 .915 17. .092 30. .990 1. .00 32 .99 1SG1697
ATOM 1697 C PHE 215 84, .989 21. .431 30. .166 1. .00 32 .99 1SG1698
ATOM 1698 0 PHE 215 84, .376 21. .168 31, .200 1. .00 32 .99 1SG1699
ATOM 1699 N ALA 216 86, .239 21, .920 30, .184 1. .00 33 .56 1SG1700
ATOM 1700 CA ALA 216 86 .965 22 .078 31, .413 1. .00 33 .56 1SG1701
ATOM 1701 CB ALA 216 88 .415 22, .544 31, .191 1. .00 33 .56 1SG1702
ATOM 1702 C ALA 216 86, .304 23. .072 32, .320 1. .00 33 .56 1SG1703
ATOM 1703 O ALA 216 86, .204 22, .839 33. .523 1. .00 33 .56 1SG1704
ATOM 1704 N HIS 217 85, .845 24. .217 31, .780 1. .00 36 .19 1SG1705
ATOM 1705 CA HIS 217 85 .250 25 .232 32 .609 1. .00 36 .19 1SG1706
ATOM 1706 NDl HIS 217 86 .554 27, .490 30 .189 1, .00 36 .19 1SG1707
ATOM 1707 CG HIS 217 86, .129 27, .339 31, .488 1. .00 36 .19 1SG1708
ATOM 1708 CB HIS 217 84, .920 26, .542 31, .878 1. .00 36, .19 1SG1709
ATOM 1709 NE2 HIS 217 87, .964 28, .647 31, .465 1, .00 36 .19 1SG1710
ATOM 1710 CD2 HIS 217 86, .996 28, .047 32, .256 1, .00 36 .19 1SG1711
ATOM 1711 CE1 HIS 217 87, .656 28, .284 30, .235 1, .00 36 .19 1SG1712
ATOM 1712 C HIS 217 83, .956 24, .758 33. .190 1. .00 36, .19 1SG1713
ATOM 1713 O HIS 217 83, .633 25. .057 34. .338 1. .00 36, .19 1SG1714
ATOM 1714 N PHE 218 83 .156 24. .038 32. .385 1. .00 37 .26 1SG1715
ATOM 1715 CA PHE 218 81, .858 23, .591 32. .805 1, .00 37 .26 1SG1716
ATOM 1716 CB PHE 218 81, .132 22, .849 31, .663 1. .00 37, .26 1SG1717
ATOM 1717 CG PHE 218 79. .924 22, .149 32, .184 1. .00 37, .26 1SG1718
ATOM 1718 CDl PHE 218 80 .031 20, .864 32 , .667 1. .00 37 .26 1SG1719
ATOM 1719 CD2 PHE 218 78. .692 22. .758 32, .181 1. .00 37 .26 1SG1720
ATOM 1720 CE1 PHE 218 78, .931 20. .197 33, .149 1. .00 37 .26 1SG1721
ATOM 1721 CE2 PHE 218 77, .587 22. .095 32, .663 1, .00 37, .26 1SG1722
ATOM 1722 CZ PHE 218 77. .704 20. .814 33 , ,148 1. .00 37, .26 1SG1723
ATOM 1723 C PHE 218 81. .971 22. .657 33, .971 1. .00 37 .26 1SG1724
ATOM 1724 O PHE 218 81, .328 22. .852 35, ,002 1. .00 37, .26 1SG1725
ATOM 1725 N THR 219 82. .835 21. .636 33, .847 1. .00 36, .82 1SG1726 ATOM 1726 CA THR 219 82.,955 20..604 34.,837 1..00 36..82 1SG1727
ATOM 1727 CB THR 219 83. ,903 19. .512 34. .440 1. .00 36. .82 1SG1728
ATOM 1728 OGl THR 219 83. .728 18. .388 35. .291 1. .00 36. .82 1SG1729
ATOM 1729 CG2 THR 219 85. .345 20. .038 34. .544 1. ,00 36. .82 1SG1730
ATOM 1730 C THR 219 83. .424 21. .195 36. .132 1. .00 36. .82 1SG1731
ATOM 1731 O THR 219 83. .125 20. .671 37, .204 1. .00 36. .82 1SG1732
ATOM 1732 N ALA 220 84. .203 22. .286 36, .063 1. .00 36. .52 1SG1733
ATOM 1733 CA ALA 220 84. .721 22. .953 37. .225 1. .00 36. .52 1SG1734
ATOM 1734 CB ALA 220 85. .616 24. .156 36. .874 1. .00 36. .52 1SG1735
ATOM 1735 C ALA 220 83. .576 23. .466 38. .048 1. .00 36. .52 1SG1736
ATOM 1736 O ALA 220 83. .662 23. .502 39. .273 1. .00 36. .52 1SG1737
ATOM 1737 N GLY 221 82. .472 23. .892 37, .403 1. .00 36, .00 1SG1738
ATOM 1738 CA GLY 221 81, .351 24. .409 38, .141 1. .00 36, .00 1SG1739
ATOM 1739 C GLY 221 81, .470 25. .899 38, .189 1. .00 36. .00 1SG1740
ATOM 1740 O GLY 221 80. .808 26, .565 38, .983 1, .00 36. .00 1SG1741
ATOM 1741 N VAL 222 82. .375 26. .441 37. .354 1. ,00 37. .83 1SG1742
ATOM 1742 CA VAL 222 82. .638 27. .846 37. .251 1. .00 37, .83 1SG1743
ATOM 1743 CB VAL 222 83. .881 28. .130 36, .462 1. .00 37, .83 1SG1744
ATOM 1744 CGI VAL 222 84. .052 29. .652 36, .349 1. .00 37, .83 1SG1745
ATOM 1745 CG2 VAL 222 85. .062 27, .413 37, .138 1. .00 37 .83 1SG1746
ATOM 1746 C VAL 222 81. .517 28, .589 36 .593 1, .00 37 .83 1SG1747
ATOM 1747 O VAL 222 81 .182 29, .689 37, .027 1. .00 37 .83 1SG1748
ATOM 1748 N PHE 223 80. .911 28. .037 35, .519 1. .00 40, .43 1SG1749
ATOM 1749 CA PHE 223 79, .918 28. .835 34 , .854 1. .00 40, .43 1SG1750
ATOM 1750 CB PHE 223 79, .596 28, .429 33, .407 1. .00 40, .43 1SG1751
ATOM 1751 CG PHE 223 80, .621 29, .086 32, .555 1. .00 40, .43 1SG1752
ATOM 1752 CDl PHE 223 80 .424 30, .389 32, .157 1. .00 40 .43 1SG1753
ATOM 1753 CD2 PHE 223 81 .769 28, .435 32, .173 1. .00 40 .43 1SG1754
ATOM 1754 CE1 PHE 223 81 .350 31, .034 31 .375 1. .00 40 .43 1SG1755
ATOM 1755 CE2 PHE 223 82 .699 29 .076 31 .389 1. .00 40 .43 1SG1756
ATOM 1756 CZ PHE 223 82, .491 30, .375 30, .988 1. .00 40, .43 1SG1757
ATOM 1757 C PHE 223 78, .638 28, .860 35, .613 1. .00 40, .43 1SG1758
ATOM 1758 O PHE 223 77, .685 28 .151 35, .288 1. .00 40 .43 1SG1759
ATOM 1759 N ASN 224 78, .590 29, .740 36 .630 1. .00 42 .21 1SG1760
ATOM 1760 CA ASN 224 77, .415 29, .940 37 .422 1, .00 42 .21 1SG1761
ATOM 1761 CB ASN 224 77 .404 29, .134 38 .735 1. .00 42 .21 1SG1762
ATOM 1762 CG ASN 224 77 .310 27 .647 38 .431 1, .00 42 .21 1SG1763
ATOM 1763 ODl ASN 224 76, .713 27, .231 37, .441 1. .00 42 , .21 1SG1764
ATOM 1764 ND2 ASN 224 77, .915 26, .814 39, .320 1. .00 42 , .21 1SG1765
ATOM 1765 C ASN 224 77, .449 31, .377 37, .849 1. .00 42 , .21 1SG1766
ATOM 1766 O ASN 224 78 .519 31, .909 38, .136 1. .00 42, .21 1SG1767
ATOM 1767 N VAL 225 76 .288 32 .064 37, .891 1, .00 43, .16 1SG1768
ATOM 1768 CA VAL 225 76 .336 33 .404 38 .404 1, .00 43, .16 1SG1769
ATOM 1769 CB VAL 225 76 .617 34 .487 37 .395 1. .00 43, .16 1SG1770
ATOM 1770 CGI VAL 225 77 .945 34 .171 36 .688 1. .00 43 .16 1SG1771
ATOM 1771 CG2 VAL 225 75, .412 34 , .668 36 , .468 1. .00 43 , .16 1SG1772
ATOM 1772 C VAL 225 75, .018 33, .704 39, .037 1. .00 43, .16 1SG1773
ATOM 1773 O VAL 225 73, .995 33, .126 38, .673 1. .00 43, .16 1SG1774
ATOM 1774 N THR 226 75, .012 34, .619 40, .025 1. .00 42 , .18 1SG1775
ATOM 1775 CA THR 226 73 .771 34, .931 40, .662 1. .00 42, .18 1SG1776
ATOM 1776 CB THR 226 73 .781 34 .725 42, .151 1, .00 42, .18 1SG1777
ATOM 1777 OGl THR 226 72 .454 34 .749 42 .650 1. .00 42, .18 1SG1778
ATOM 1778 CG2 THR 226 74 , .613 35. .834 42. .816 1. ,00 42, .18 1SG1779
ATOM 1779 C THR 226 73 , .469 36, .367 40, .386 1. ,00 42, .18 1SG1780
ATOM 1780 O THR 226 74, .342 37, .230 40, .475 1. .00 42 , .18 1SG1781
ATOM 1781 N LEU 227 72, .207 36, .657 40, .014 1. .00 39, .57 1SG1782
ATOM 1782 CA LEU 227 71, .851 38, .015 39, .739 1. .00 39, .57 1SG1783 ATOM 1783 CB LEU 227 71..017 38..225 38..456 1.,00 39..57 1SG1784
ATOM 1784 CG LEU 227 71. .660 37. .691 37. .159 1. .00 39. .57 1SG1785
ATOM 1785 CD2 LEU 227 71. .510 36. .170 37. .022 1. .00 39. .57 1SG1786
ATOM 1786 CDl LEU 227 73. .102 38. .198 36. .996 1. .00 39. .57 1SG1787
ATOM 1787 C LEU 227 71, .000 38. .485 40. .872 1. .00 39. .57 1SG1788
ATOM 1788 O LEU 227 70. .099 37. .778 41. .320 1. .00 39, .57 1SG1789
ATOM 1789 N SER 228 71. .275 39. .708 41. .366 1, .00 36, .27 1SG1790
ATOM 1790 CA SER 228 70. .494 40. .246 42. .439 1. .00 36, .27 1SG1791
ATOM 1791 CB SER 228 71, .303 40. .621 43. .693 1. .00 36, .27 1SG1792
ATOM 1792 OG SER 228 72 , .145 41. .730 43. .424 1. .00 36, .27 1SG1793
ATOM 1793 C SER 228 69, .860 41. .496 41, .920 1. .00 36, .27 1SG1794
ATOM 1794 O SER 228 70. .246 42. .021 40. .876 1. .00 36. .27 1SG1795
ATOM 1795 N THR 229 68, .855 42. .002 42. .653 1. .00 34. .58 1SG1796
ATOM 1796 CA THR 229 68, .106 43. .155 42. .248 1. .00 34, .58 1SG1797
ATOM 1797 CB THR 229 67, .007 43. .500 43. .209 1. .00 34, .58 1SG1798
ATOM 1798 OGl THR 229 66, .182 44 , .520 42. .666 1. .00 34, .58 1SG1799
ATOM 1799 CG2 THR 229 67, .637 43. .970 44. .531 1, .00 34, .58 1SG1800
ATOM 1800 C THR 229 69, .014 44 , .344 42, .160 1. .00 34, .58 1SG1801
ATOM 1801 O THR 229 68, .818 45, .218 41, .318 1. .00 34, .58 1SG1802
ATOM 1802 N GLU 230 70, .029 44, .408 43, .039 1. .00 33, .51 1SG1803
ATOM 1803 CA GLU 230 70, .916 45, .534 43, .143 1. .00 33 .51 1SG1804
ATOM 1804 CB GLU 230 71, .961 45, .353 44, .256 1. .00 33 .51 1SG1805
ATOM 1805 CG GLU 230 71, .349 45, .290 45, .656 1, .00 33 .51 1SG1806
ATOM 1806 CD GLU 230 72, .479 45, .108 46. .659 1, .00 33 .51 1SG1807
ATOM 1807 OEl GLU 230 73 .498 45, .842 46. .541 1. .00 33 .51 1SG1808
ATOM 1808 OE2 GLU 230 72 .342 44, .233 47. .553 1, .00 33 .51 1SG1809
ATOM 1809 C GLU 230 71 .670 45, .764 41. .865 1, .00 33 .51 1SG1810
ATOM 1810 O GLU 230 71 .934 46, .908 41, .498 1, .00 33 .51 1SG1811
ATOM 1811 N GLU 231 72, .040 44. .689 41, .151 1. .00 36 .12 1SG1812
ATOM 1812 CA GLU 231 72 .852 44, .800 39. .969 1, .00 36 .12 1SG1813
ATOM 1813 CB GLU 231 73, .236 43, .441 39. .354 1. .00 36 .12 1SG1814
ATOM 1814 CG GLU 231 74 .435 42. .761 40, .021 1. .00 36 .12 1SG1815
ATOM 1815 CD GLU 231 74 .057 42, .340 41. .432 1, .00 36 .12 1SG1816
ATOM 1816 OEl GLU 231 73 .904 43, .243 42. .297 1. .00 36 .12 1SG1817
ATOM 1817 OE2 GLU 231 73 .927 41, .109 41, .665 1. .00 36 .12 1SG1818
ATOM 1818 C GLU 231 72 .179 45, .599 38 .895 1. .00 36 .12 1SG1819
ATOM 1819 O GLU 231 72 .857 46, .233 38, .087 1. .00 36 .12 1SG1820
ATOM 1820 N ILE 232 70 .837 45, .594 38, .829 1. .00 41 .97 1SG1821
ATOM 1821 CA ILE 232 70 .198 46. .228 37, .710 1. .00 41 .97 1SG1822
ATOM 1822 CB ILE 232 69, .091 45, .382 37. .140 1, .00 41 .97 1SG1823
ATOM 1823 CG2 ILE 232 68, .397 46, .159 36. .009 1. .00 41, .97 1SG1824
ATOM 1824 CGI ILE 232 69 .650 44, .024 36. .685 1. .00 41, .97 1SG1825
ATOM 1825 CDl ILE 232 68, .567 42, .990 36. .382 1, .00 41. .97 1SG1826
ATOM 1826 C ILE 232 69 .608 47, .553 38. .087 1, .00 41. .97 1SG1827
ATOM 1827 O ILE 232 69, .203 47, .786 39. .225 1. .00 41, .97 1SG1828
ATOM 1828 N SER 233 69, .594 48, .471 37. .095 1. .00 56, .99 1SG1829
ATOM 1829 CA SER 233 69, .028 49, .784 37, .210 1. .00 56, .99 1SG1830
ATOM 1830 CB SER 233 69, .526 50, .764 36, .134 1, .00 56. .99 1SG1831
ATOM 1831 OG SER 233 70, .922 50, .981 36, .279 1, .00 56, .99 1SG1832
ATOM 1832 C SER 233 67, .550 49, .623 37, .028 1. .00 56, .99 1SG1833
ATOM 1833 O SER 233 67, .031 48, .510 37, .072 1, .00 56, .99 1SG1834
ATOM 1834 N ASN 234 66, .829 50, .746 36, .841 1, .00 71, .98 1SG1835
ATOM 1835 CA ASN 234 65, .396 50. .712 36, .756 1. .00 71, .98 1SG1836
ATOM 1836 CB ASN 234 64, .737 52. .090 36, .936 1. .00 71, .98 1SG1837
ATOM 1837 CG ASN 234 64, .946 52, .525 38, .379 1. .00 71, .98 1SG1838
ATOM 1838 ODl ASN 234 64, .731 51. .752 39, .311 1. .00 71, .98 1SG1839
ATOM 1839 ND2 ASN 234 65, .383 53. .799 38, .572 1. .00 71, .98 1SG1840 ATOM 1840 C ASN 234 64..925 50..168 35..452 1..00 71..98 1SG1841
ATOM 1841 O ASN 234 65. .644 50. .167 34. .456 1. ,00 71. .98 1SG1842
ATOM 1842 N HIS 235 63. .675 49. .661 35. ,485 1. ,00 83. ,05 1SG1843
ATOM 1843 CA HIS 235 62. .948 49. .073 34. ,399 1. ,00 83. .05 1SG1844
ATOM 1844 NDl HIS 235 62. .490 46. .911 31. ,793 1. ,00 83. .05 1SG1845
ATOM 1845 CG HIS 235 63. .031 48. .157 32. .024 1. ,00 83. .05 1SG1846
ATOM 1846 CB HIS 235 63. .818 48. .531 33. .248 1. ,00 83. .05 1SG1847
ATOM 1847 NE2 HIS 235 61. .962 48. .166 30. .035 1. ,00 83. .05 1SG1848
ATOM 1848 CD2 HIS 235 62. .699 48. .910 30. .939 1. ,00 83. ,05 1SG1849
ATOM 1849 CE1 HIS 235 61. .862 46. .972 30. .592 1. .00 83. .05 1SG1850
ATOM 1850 C HIS 235 62. .290 47. .905 35, .039 1. .00 83. .05 1SG1851
ATOM 1851 o HIS 235 61. .534 48. .051 35, .999 1. .00 83. .05 1SG1852
ATOM 1852 N PHE 236 62. .559 46. .694 34, .525 1. .00 89. .54 1SG1853
ATOM 1853 CA PHE 236 61. .994 45. .600 35. .239 1. .00 89. .54 1SG1854
ATOM 1854 CB PHE 236 61, .850 44. .261 34. .469 1, .00 89, .54 1SG1855
ATOM 1855 CG PHE 236 63. .291 43. .527 34. .210 1. .00 89, .54 1SG1856
ATOM 1856 CDl PHE 236 64. .277 43, .641 33. .229 1. .00 89, .54 1SG1857
ATOM 1857 CD2 PHE 236 64. .318 42. .588 34. .553 1. .00 89. .54 1SG1858
ATOM 1858 CE1 PHE 236 65. .057 42. .635 33 .868 1 .00 89 .54 1SG1859
ATOM 1859 CE2 PHE 236 64. .208 43. .455 33 .531 1. .00 89, .54 1SG1860
ATOM 1860 CZ PHE 236 63. .986 42. .703 34. .674 1. .00 89, .54 1SG1861
ATOM 1861 C PHE 236 62, .863 45, .419 36, .438 1. .00 89, .54 1SG1862
ATOM 1862 O PHE 236 64, .017 45. .845 36, .453 1. .00 89, .54 1SG1863
ATOM 1863 N VAL 237 62 .302 44. .840 37 .511 1 .00 76 .00 1SG1864
ATOM 1864 CA VAL 237 63, .074 44. .656 38 .702 1 .00 76 .00 1SG1865
ATOM 1865 CB VAL 237 62, .591 45. .477 39, .861 1. .00 76, .00 1SG1866
ATOM 1866 CGI VAL 237 62, .740 46. .966 39. .503 1. .00 76, .00 1SG1867
ATOM 1867 CG2 VAL 237 61 .149 45 .056 40 .191 1 .00 76 .00 1SG1868
ATOM 1868 C VAL 237 62 .932 43, .227 39 .092 1 .00 76 .00 1SG1869
ATOM 1869 O VAL 237 61 .956 42. .571 38 .732 1 .00 76 .00 1SG1870
ATOM 1870 N GLN 238 63, .927 42. .694 39, .824 1. .00 62. .88 1SG1871
ATOM 1871 CA GLN 238 63, .800 41, .341 40, .264 1. .00 62. .88 1SG1872
ATOM 1872 CB GLN 238 65 .152 40 .640 40 .482 1 .00 62 .88 1SG1873
ATOM 1873 CG GLN 238 65 .957 40 .454 39 .194 1 .00 62 .88 1SG1874
ATOM 1874 CD GLN 238 65 .227 39, .437 38 .327 1, .00 62 .88 1SG1875
ATOM 1875 OEl GLN 238 64, .174 38, .925 38 .703 1, .00 62 .88 1SG1876
ATOM 1876 NE2 GLN 238 65 .801 39 .135 37 .132 1 .00 62 .88 1SG1877
ATOM 1877 C GLN 238 63 .117 41 .426 41 .582 1 .00 62 .88 1SG1878
ATOM 1878 O GLN 238 63 .738 41 .277 42 .633 1 .00 62 .88 1SG1879
ATOM 1879 N ASN 239 61 .797 41, .681 41 .538 1, .00 50, .30 1SG1880
ATOM 1880 CA ASN 239 61, .010 41, .793 42 .726 1, .00 50, .30 1SG1881
ATOM 1881 CB ASN 239 60 .697 43 .254 43 .102 1 .00 50 .30 1SG1882
ATOM 1882 CG ASN 239 60 .103 43 .299 44 .505 1 .00 50, .30 1SG1883
ATOM 1883 ODl ASN 239 59, .003 42, .812 44 .757 1, .00 50, .30 1SG1884
ATOM 1884 ND2 ASN 239 60, .860 43, .913 45 .454 1, .00 50. .30 1SG1885
ATOM 1885 C ASN 239 59 .721 41 .108 42 .423 1 .00 50 .30 1SG1886
ATOM 1886 O ASN 239 59 .285 41 .065 41 .274 1 .00 50 .30 1SG1887
ATOM 1887 N SER 240 59 .080 40, .541 43 .457 1 .00 39. .64 1SG1888
ATOM 1888 CA SER 240 57, .844 39, .853 43 .250 1 .00 39. .64 1SG1889
ATOM 1889 CB SER 240 57, .300 39. .224 44 .541 1, .00 39. .64 1SG1890
ATOM 1890 OG SER 240 56 .075 38 .562 44 .273 1 .00 39 .64 1SG1891
ATOM 1891 C SER 240 56, .836 40. .849 42 .778 1 .00 39. .64 1SG1892
ATOM 1892 O SER 240 55, .944 40, .520 41 .997 1 .00 39. .64 1SG1893
ATOM 1893 N GLN 241 56, .954 42, .107 43 .241 1, .00 38. .38 1SG1894
ATOM 1894 CA GLN 241 55 .980 43 .097 42 .883 1 .00 38 .38 1SG1895
ATOM 1895 CB GLN 241 56 .255 44, .462 43 .536 1 .00 38. .38 1SG1896
ATOM 1896 CG GLN 241 55, .222 45. .529 43 .166 1, .00 38. .38 1SG1897 ATOM 1897 CD GLN 241 55..606 46,.821 43..872 1..00 38.,38 1SG1898
ATOM 1898 OEl GLN 241 56, .082 45, .690 43. .788 1. .00 38. ,38 1SG1899
ATOM 1899 NE2 GLN 241 54, .526 47, .498 43, .397 1. .00 38. .38 1SG1900
ATOM 1900 C GLN 241 55 .985 43 .317 41, .403 1. .00 38. .38 1SG1901
ATOM 1901 O GLN 241 54, .930 43. .296 40, .769 1. ,00 38. .38 1SG1902
ATOM 1902 N GLY 242 57 .175 43, .515 40, .798 1. .00 35. .82 1SG1903
ATOM 1903 CA GLY 242 57 .220 43 .774 39, .388 1. .00 35. .82 1SG1904
ATOM 1904 C GLY 242 56 .710 42 .572 38, .668 1, .00 35, .82 1SG1905
ATOM 1905 O GLY 242 55, .923 42, .673 37, .727 1. .00 35, .82 1SG1906
ATOM 1906 N LEU 243 57 .140 41 .387 39, .123 1. .00 36. .65 1SG1907
ATOM 1907 CA LEU 243 56 .756 40 .153 38 .510 1. .00 36. .65 1SG1908
ATOM 1908 CB LEU 243 57 .484 38 .926 39 .063 1, .00 36. .65 1SG1909
ATOM 1909 CG LEU 243 59, .005 38. .955 38 .816 1, .00 36. .65 1SG1910
ATOM 1910 CD2 LEU 243 59 .326 39 .190 37, .331 1. .00 36. .65 1SG1911
ATOM 1911 CDl LEU 243 59 .689 37 .703 39 .387 1, .00 36. .65 1SG1912
ATOM 1912 C LEU 243 55 .285 39 .992 38 .698 1. .00 36. .65 1SG1913
ATOM 1913 O LEU 243 54 .641 39 .198 38 .017 1 .00 36 .65 1SG1914
ATOM 1914 N GLY 244 54 .717 40 .727 39 .665 1, .00 40, .23 1SG1915
ATOM 1915 CA GLY 244 53 .320 40 .614 39 .964 1, .00 40 .23 1SG1916
ATOM 1916 C GLY 244 52 .502 40 .925 38 .749 1 .00 40 .23 1SG1917
ATOM 1917 O GLY 244 51 .424 40 .361 38 .570 1 .00 40 .23 1SG1918
ATOM 1918 N ASN 245 52 .950 41 .859 37 .891 1, .00 48 .53 1SG1919
ATOM 1919 CA ASN 245 52 .120 42 .167 36 .763 1, .00 48 .53 1SG1920
ATOM 1920 CB ASN 245 52 .739 43. .236 35, .844 1, .00 48, .53 1SG1921
ATOM 1921 CG ASN 245 51 .702 43 .643 34, .804 1, .00 48, .53 1SG1922
ATOM 1922 ODl ASN 245 51, .124 42. .807 34, .111 1. .00 48. .53 1SG1923
ATOM 1923 ND2 ASN 245 51. .455 44. .975 34, .693 1. .00 48, .53 1SG1924
ATOM 1924 C ASN 245 51 .922 40. .925 35, .941 1. .00 48, .53 1SG1925
ATOM 1925 O ASN 245 50 .796 40 .588 35 .573 1, .00 48, .53 1SG1926
ATOM 1926 N VAL 246 53, .030 40. .242 35. .598 1. .00 61 .76 1SG1927
ATOM 1927 CA VAL 246 53, .021 39. .049 34. .796 1. .00 61, .76 1SG1928
ATOM 1928 CB VAL 246 54 .368 38 .794 34, .189 1, .00 61, .76 1SG1929
ATOM 1929 CGI VAL 246 54 .668 39 .917 33, .180 1, .00 61, .76 1SG1930
ATOM 1930 CG2 VAL 246 55, .401 38. .720 35 .327 1. .00 61 .76 1SG1931
ATOM 1931 C VAL 246 52, .601 37. .788 35, .508 1. .00 61, .76 1SG1932
ATOM 1932 O VAL 246 51 .768 37. .045 34, .987 1, .00 61, .76 1SG1933
ATOM 1933 N LEU 247 53 .177 3 .477 36, .696 1, .00 73, .21 1SG1934
ATOM 1934 CA LEU 247 52, .833 36 .206 37 .273 1. .00 73, .21 1SG1935
ATOM 1935 CB LEU 247 53, .925 35, .130 37, .122 1. .00 73. .21 1SG1936
ATOM 1936 CG LEU 247 54, .250 34. .741 35, .668 1. .00 73. .21 1SG1937
ATOM 1937 CD2 LEU 247 54, .892 33 .352 35. .597 1, .00 73 , .21 1SG1938
ATOM 1938 CDl LEU 247 55, .069 35 .819 3 .944 1. .00 73. .21 1SG1939
ATOM 1939 C LEU 247 52, .577 36, .299 38. .742 1. .00 73. .21 1SG1940
ATOM 1940 O LEU 247 53, .496 36, .149 39. .547 1. .00 73. .21 1SG1941
ATOM 1941 N SER 248 51, .306 36, .472 39. .151 1. .00 79. .16 1SG1942
ATOM 1942 CA SER 248 51. .099 36, .523 40. .567 1. .00 79. .16 1SG1943
ATOM 1943 CB SER 248 50. .829 37. .949 41. ,084 1. .00 79. .16 1SG1944
ATOM 1944 OG SER 248 49. .641 38. .470 40. .508 1. ,00 79. ,16 1SG1945
ATOM 1945 C SER 248 49. .928 35. .677 40. .956 1. ,00 79. ,16 1SG1946
ATOM 1946 O SER 248 48. .777 36. .049 40. .727 1. .00 79. ,16 1SG1947
ATOM 1947 N ARG 249 50. .185 34. .483 41. .536 1. .00 77. .62 1SG1948
ATOM 1948 CA ARG 249 51. .498 33. .916 41. .631 1. .00 77. .62 1SG1949
ATOM 1949 CB ARG 249 52. .234 33. ,814 40. .286 1. .00 77. .62 1SG1950
ATOM 1950 CG ARG 249 51. .506 32. .935 39. .268 1. .00 77. .62 1SG1951
ATOM 1951 CD ARG 249 50. .193 33. .546 38. .774 1. .00 77. .62 1SG1952
ATOM 1952 NE ARG 249 49. .589 32. .596 37. ,798 1. .00 77. ,62 1SG1953
ATOM 1953 CZ ARG 249 48. ,784 31. .589 38. ,236 1. ,00 77. .62 1SG1954 ATOM 1954 NHl ARG 249 48.534 31..446 39..572 1.00 77.,62 1SG1955
ATOM 1955 NH2 ARG 249 48. 222 30. .722 37. .343 1. 00 77. ,62 1SG1956
ATOM 1956 C ARG 249 52. .395 34. .574 42. ,634 1. 00 77. ,62 1SG1957
ATOM 1957 O ARG 249 52. .032 34. .778 43. .792 1. 00 77. .62 1SG1958
ATOM 1958 N ILE 250 53. .627 34. .913 42. .189 1. .00 67. .99 1SG1959
ATOM 1959 CA ILE 250 54. ,655 35. .329 43. .101 1. .00 67. .99 1SG1960
ATOM 1960 CB ILE 250 55. .998 35, .642 42. .516 1. .00 67. .99 1SG1961
ATOM 1961 CG2 ILE 250 56. .454 34 , .402 41. .730 1. .00 67. .99 1SG1962
ATOM 1962 CGI ILE 250 56. .005 36, .926 41. .694 1. .00 67. .99 1SG1963
ATOM 1963 CDl ILE 250 57. .432 37. .450 41, .588 1. .00 67. .99 1SG1964
ATOM 1964 C ILE 250 54. .238 36, .492 43, .935 1. .00 67. .99 1SG1965
ATOM 1965 O ILE 250 54. .618 36, .572 45, .102 1. .00 67. .99 1SG1966
ATOM 1966 N ALA 251 53. .493 37, .458 43, .384 1. .00 56. .28 1SG1967
ATOM 1967 CA ALA 251 53. .093 38, .525 44, .252 1. .00 56. .28 1SG1968
ATOM 1968 CB ALA 251 52. .276 39 .610 43, .530 1. .00 56, .28 1SG1969
ATOM 1969 C ALA 251 52. .226 37 .941 45, .325 1. .00 56, .28 1SG1970
ATOM 1970 O ALA 251 52. .368 38 .277 46, .500 1. .00 56, .28 1SG1971
ATOM 1971 N GLU 252 51. .292 37 .047 44. .942 1. .00 50, .75 1SG1972
ATOM 1972 CA GLU 252 50, .371 36 .490 45. .892 1. .00 50. .75 1SG1973
ATOM 1973 CB GLU 252 49, .268 35 .654 45 .224 1. .00 50, .75 1SG1974
ATOM 1974 CG GLU 252 48, .217 35 .137 46 .208 1. .00 50 .75 1SG1975
ATOM 1975 CD GLU 252 47, .369 36 .321 46 .651 1. .00 50 .75 1SG1976
ATOM 1976 OEl GLU 252 47. .641 37, .455 46, .172 1. .00 50. .75 1SG1977
ATOM 1977 OE2 GLU 252 46. .439 36, .108 47, .473 1. .00 50, .75 1SG1978
ATOM 1978 C GLU 252 51. .056 35, .602 46. .890 1. .00 50, .75 1SG1979
ATOM 1979 O GLU 252 50. .903 35 .791 48, .096 1. .00 50, .75 1SG1980
ATOM 1980 N ILE 253 51. .835 34 .604 46, .420 1, .00 49, .88 1SG1981
ATOM 1981 CA ILE 253 52. .445 33 .683 47 .340 1, .00 49 .88 1SG1982
ATOM 1982 CB ILE 253 53, .145 32 .553 46 .644 1, .00 49, .88 1SG1983
ATOM 1983 CG2 ILE 253 53, .887 31 .728 47 .709 1, .00 49 .88 1SG1984
ATOM 1984 CGI ILE 253 52, .142 31 .732 45 .817 1. .00 49 .88 1SG1985
ATOM 1985 CDl ILE 253 51, .033 31 .100 46 .656 1, .00 49 .88 1SG1986
ATOM 1986 C ILE 253 53, .470 34 .409 48 .145 1, .00 49 .88 1SG1987
ATOM 1987 O ILE 253 53, .454 34 .366 49 .374 1. .00 49 .88 1SG1988
ATOM 1988 N TYR 254 54, .382 35 .125 47 .462 1. .00 55 .25 1SG1989
ATOM 1989 CA TYR 254 55, .342 35 .900 48 .185 1, .00 55 .25 1SG1990
ATOM 1990 CB TYR 254 56, .780 35 .816 47 .649 1. .00 55 .25 1SG1991
ATOM 1991 CG TYR 254 57 .370 34 .600 48 .269 1. .00 55 .25 1SG1992
ATOM 1992 CDl TYR 254 57 .968 34 .713 49 .502 1. .00 55 .25 1SG1993
ATOM 1993 CD2 TYR 254 57 .324 33 .369 47 .657 1 .00 55 .25 1SG1994
ATOM 1994 CE1 TYR 254 58 .524 33 .623 50 .123 1, .00 55 .25 1SG1995
ATOM 1995 CE2 TYR 254 57 .879 32 .273 48 .276 1, .00 55 .25 1SG1996
ATOM 1996 CZ TYR 254 58 .480 32 .399 4 .508 1, .00 55 .25 1SG1997
ATOM 1997 OH TYR 254 59 .052 31 .281 50 .149 1, .00 55 .25 1SG1998
ATOM 1998 C TYR 254 54 .873 37 .299 48 .113 1 .00 55 .25 1SG1999
ATOM 1999 O TYR 254 55, .312 38 .093 47 .280 1. .00 55, .25 1SG2000
ATOM 2000 N ILE 255 53, .961 37 .601 49, .052 1. .00 61, .63 1SG2001
ATOM 2001 CA ILE 255 53, .255 38 .833 49, .180 1. .00 61, .63 1SG2002
ATOM 2002 CB ILE 255 52, .074 38 .756 50, .103 1. .00 61, .63 1SG2003
ATOM 2003 CG2 ILE 255 52, .595 38 .477 51 .523 1. .00 61, .63 1SG2004
ATOM 2004 CGI ILE 255 51, .218 40 .028 49, .988 1. .00 61. .63 1SG2005
ATOM 2005 CDl ILE 255 49. .855 39 .908 50 .669 1. .00 61. .63 1SG2006
ATOM 2006 C ILE 255 54. .159 39 .876 49. .706 1, .00 61, .63 1SG2007
ATOM 2007 O ILE 255 55, .135 39 .592 50. .401 1, .00 61, .63 1SG2008
ATOM 2008 N LEU 256 53, .863 41 .129 49, .327 1. .00 62, .31 1SG2009
ATOM 2009 CA LEU 256 54, .675 42 .226 49, .729 1. .00 62, .31 1SG2010
ATOM 2010 CB LEU 256 55, .090 42 .209 51, .213 1. .00 62, .31 1SG2011 ATOM 2011 CG LEU 256 55.,968 43..408 51..619 1..00 62..31 1SG2012
ATOM 2012 CD2 LEU 256 56. .553 43, .217 53. .027 1. .00 62. .31 1SG2013
ATOM 2013 CDl LEU 256 55. .208 44, .735 51, .465 1. .00 62. .31 1SG2014
ATOM 2014 C LEU 256 55. .886 42, .136 48, .884 1. .00 62. .31 1SG2015
ATOM 2015 O LEU 256 56. .317 41, .051 48, .499 1. .00 62. .31 1SG2016
ATOM 2016 N SER 257 56. .453 43, .298 48, .536 1. .00 60. .82 1SG2017
ATOM 2017 CA SER 257 57. .594 43 .265 47 .692 1, .00 60, .82 1SG2018
ATOM 2018 CB SER 257 58, .168 44, .656 47 .375 1. .00 60, .82 1SG2019
ATOM 2019 OG SER 257 58. .650 45, .268 48, .563 1. .00 60, .82 1SG2020
ATOM 2020 C SER 257 58. .650 42, .480 48, .380 1. .00 60. .82 1SG2021
ATOM 2021 O SER 257 59. .053 42 , .775 49, .505 1. .00 60. .82 1SG2022
ATOM 2022 N GLN 258 59, .104 41 .427 47 .688 1. .00 54. .16 1SG2023
ATOM 2023 CA GLN 258 60. .174 40, .615 48 .155 1. .00 54, .16 1SG2024
ATOM 2024 CB GLN 258 59. .792 39, .138 48, .357 1. .00 54, .16 1SG2025
ATOM 2025 CG GLN 258 58. .755 38. .919 49, .461 1. .00 54, .16 1SG2026
ATOM 2026 CD GLN 258 59. .415 39. .212 50, .802 1. .00 54, .16 1SG2027
ATOM 2027 OEl GLN 258 58. .780 39 .116 51 .851 1. .00 54, .16 1SG2028
ATOM 2028 NE2 GLN 258 60. .725 39 .577 50 .772 1, .00 54, .16 1SG2029
ATOM 2029 C GLN 258 61. .144 40. .674 47 .031 1, .00 54. .16 1SG2030
ATOM 2030 O GLN 258 60. .750 40. .857 45 .880 1. .00 54, .16 1SG2031
ATOM 2031 N PRO 259 62. .401 40, .577 47, .330 1. .00 47, .14 1SG2032
ATOM 2032 CA PRO 259 63. .379 40 .607 46 .286 1. .00 47 .14 1SG2033
ATOM 2033 CD PRO 259 62, .929 41, .074 48 .587 1. .00 47 .14 1SG2034
ATOM 2034 CB PRO 259 64. .709 40, .965 46 .954 1. .00 47 .14 1SG2035
ATOM 2035 CG PRO 259 64. .440 40, .829 48 .465 1, .00 47 .14 1SG2036
ATOM 2036 C PRO 259 63. .370 39. .289 45, .596 1. .00 47, .14 1SG2037
ATOM 2037 O PRO 259 62. .924 38 .309 46 .190 1. .00 47 .14 1SG2038
ATOM 2038 N PHE 260 63. .837 39 .242 44 .337 1, .00 43 .17 1SG2039
ATOM 2039 CA PHE 260 63, .818 37 .987 43 .658 1, .00 43 .17 1SG2040
ATOM 2040 CB PHE 260 62, .956 38. .053 42, .387 1. .00 43, .17 1SG2041
ATOM 2041 CG PHE 260 62. .275 36, .740 42. .246 1. .00 43. .17 1SG2042
ATOM 2042 CDl PHE 260 62 .868 35 .665 41 .635 1 .00 43 .17 1SG2043
ATOM 2043 CD2 PHE 260 61. .003 36 .603 42 .754 1. .00 43 .17 1SG2044
ATOM 2044 CE1 PHE 260 62. .183 34, .476 41 .546 1. .00 43 .17 1SG2045
ATOM 2045 CE2 PHE 260 60, .319 35, .416 42. .662 1. .00 43. .17 1SG2046
ATOM 2046 CZ PHE 260 60. .915 34, .342 42 .054 1, .00 43. .17 1SG2047
ATOM 2047 C PHE 260 65 .246 37 .754 43 .266 1. .00 43 .17 1SG2048
ATOM 2048 O PHE 260 65. .942 38 .689 42 .869 1. .00 43 .17 1SG2049
ATOM 2049 N MET 261 65, .738 36, .506 43. .394 1, .00 39 .81 1SG2050
ATOM 2050 CA MET 261 67, .106 36, .233 43, .052 1, .00 39. .81 1SG2051
ATOM 2051 CB MET 261 67, .930 35, .669 44, .222 1. .00 39. .81 1SG2052
ATOM 2052 CG MET 261 68 .110 36 .660 45 .374 1. .00 39 .81 1SG2053
ATOM 2053 SD MET 261 69, .116 38 .118 44 .965 1. .00 39, .81 1SG2054
ATOM 2054 CE MET 261 68, .981 38, .870 46, .612 1. .00 39, .81 1SG2055
ATOM 2055 C MET 261 67, .095 35, .197 41, .975 1. .00 39, .81 1SG2056
ATOM 2056 0 MET 261 66, .280 34, .276 42, .006 1. .00 39. .81 1SG2057
ATOM 2057 N VAL 262 67 .997 35 .327 40 .979 1. .00 38. .89 1SG2058
ATOM 2058 CA VAL 262 68, .006 34, .371 39 .907 1. .00 38. .89 1SG2059
ATOM 2059 CB VAL 262 67, .704 34. .979 38, .569 1. .00 38, .89 1SG2060
ATOM 2060 CGI VAL 262 66, .282 35. .562 38, .604 1. .00 38. .89 1SG2061
ATOM 2061 CG2 VAL 262 68. .796 36, .012 38. .242 1. .00 38. .89 1SG2062
ATOM 2062 C VAL 262 69. .366 33 .754 39. .813 1, .00 38. .89 1SG2063
ATOM 2063 O VAL 262 70, .384 34, .428 39. .963 1. .00 38. .89 1SG2064
ATOM 2064 N ARG 263 69, .420 32, .432 39. .554 1. .00 37. .91 1SG2065
ATOM 2065 CA ARG 263 70, .698 31, .791 39. .453 1. .00 37. .91 1SG2066
ATOM 2066 CB ARG 263 70. .879 30. .626 40. .443 1. .00 37. .91 1SG2067
ATOM 2067 CG ARG 263 69. .851 29. .506 40. .276 1. .00 37. .91 1SG2068 ATOM 2068 CD ARG 263 69.963 28.418 41.346 1,.00 37..91 1SG2069
ATOM 2069 NE ARG 263 71 .300 27 .777 41 .196 1 .00 37. .91 1SG2070
ATOM 2070 CZ ARG 263 71 .734 26 .883 42 .131 1, .00 37. .91 1SG2071
ATOM 2071 NHl ARG 263 70 .939 26 .568 43 .194 1, .00 37. .91 1SG2072
ATOM 2072 NH2 ARG 263 72 .964 26 .304 42 .002 1, .00 37, .91 1SG2073
ATOM 2073 C ARG 263 70 .848 31 .245 38 .069 1, .00 37, .91 1SG2074
ATOM 2074 O ARG 263 69 .965 30 .553 37 .563 1 .00 37, .91 1SG2075
ATOM 2075 N ILE .264 71 .983 31 .551 37 .406 1, .00 35, .82 1SG2076
ATOM 2076 CA ILE 264 72, .152 31 .013 36. .088 1, .00 35. .82 1SG2077
ATOM 2077 CB ILE 264 72 .272 32 .025 34, .984 1, .00 35. .82 1SG2078
ATOM 2078 CG2 ILE 264 70, .995 32 .882 34, .989 1, .00 35. .82 1SG2079
ATOM 2079 CGI ILE 264 73 .560 32 .837 35 .117 1 .00 35 .82 1SG2080
ATOM 2080 CDl ILE 264 73 .896 33 .650 33 .867 1 .00 35 .82 1SG2081
ATOM 2081 C ILE 264 73 .376 30 .156 36 .070 1 .00 35. .82 1SG2082
ATOM 2082 O ILE 264 74 .450 30 .557 36 .518 1 .00 35. .82 1SG2083
ATOM 2083 N MET 265 73 .220 28 .922 35 .548 1 .00 32 .98 1SG2084
ATOM 2084 CA MET 265 74 .300 27 .982 35 .476 1 .00 32, .98 1SG2085
ATOM 2085 CB MET 265 74 .169 26 .843 36 .501 1 .00 32. .98 1SG2086
ATOM 2086 CG MET 265 72 .940 25 .958 36 .280 1 .00 32, .98 1SG2087
ATOM 2087 SD MET 265 72 .761 24 .602 37 .478 1 .00 32, .98 1SG2088
ATOM 2088 CE MET 265 74 .060 23 .566 36 .745 1 .00 32, .98 1SG2089
ATOM 2089 C MET 265 74, .262 27 .352 34 .117 1 .00 32, .98 1SG2090
ATOM 2090 O MET 265 73, .241 27. .394 33 .432 1, .00 32, .98 1SG2091
ATOM 2091 N ALA 266 75, .391 26, .753 33, .685 1, .00 32, .75 1SG2092
ATOM 2092 CA ALA 266 75, .415 26, .122 32, .394 1, .00 32, .75 1SG2093
ATOM 2093 CB ALA 266 76, .800 26, .135 31. .725 1, .00 32, .75 1SG2094
ATOM 2094 C ALA 266 75 .012 24 .697 32 .589 1 .00 32 .75 1SG2095
ATOM 2095 O ALA 266 75 .583 23 .987 33 .415 1 .00 32 .75 1SG2096
ATOM 2096 N THR 267 73 .974 24 .257 31 .847 1 .00 34 .61 1SG2097
ATOM 2097 CA THR 267 73 .492 22 .911 31 .968 1 .00 34, .61 1SG2098
ATOM 2098 CB THR 267 72 .178 22 .690 31 .273 1 .00 34, .61 1SG2099
ATOM 2099 OGl THR 267 71, .721 21, .366 31. .509 1 .00 34, .61 1SG2100
ATOM 2100 CG2 THR 267 72. .345 22, .943 29. .766 1, .00 34, .61 1SG2101
ATOM 2101 C THR 267 74. .485 21, .933 31, .417 1, .00 34, .61 1SG2102
ATOM 2102 O THR 267 74, .785 20, .926 32. .057 1, .00 34. .61 1SG2103
ATOM 2103 N GLU 268 75, .032 22 , .206 30. .213 1, .00 37, .43 1SG2104
ATOM 2104 CA GLU 268 75, .942 21, .276 29, .602 1, .00 37. .43 1SG2105
ATOM 2105 CB GLU 268 75, .289 20, .439 28 , .487 1, .00 37. .43 1SG2106
ATOM 2106 CG GLU 268 74 , .165 19, .532 29. .003 1, .00 37. .43 1SG2107
ATOM 2107 CD GLU 268 73. .597 18, .745 27. .830 1. .00 37. .43 1SG2108
ATOM 2108 OEl GLU 268 74. .289 17. .795 27. .375 1. .00 37. .43 1SG2109
ATOM 2109 OE2 GLU 268 72. .472 19. .078 27, .371 1, .00 37. .43 1SG2110
ATOM 2110 C GLU 268 77, .068 22. .064 29, .004 1, .00 37. .43 1SG2111
ATOM 2111 O GLU 268 77, .021 23. .292 28, .963 1. .00 37. .43 1SG2112
ATOM 2112 N PRO 269 78 , .108 21. .391 28, .578 1, .00 41. .22 1SG2113
ATOM 2113 CA PRO 269 79. .269 22. .017 28. .003 1. .00 41. .22 1SG2114
ATOM 2114 CD PRO 269 78. .278 19. .963 28. .781 1. .00 41. .22 1SG2115
ATOM 2115 CB PRO 269 80. .309 20. .906 27. .845 1. .00 41. ,22 1SG2116
ATOM 2116 CG PRO 269 79. .486 19. .604 27. .898 1. .00 41. ,22 1SG2117
ATOM 2117 C PRO 269 78. .938 22. .705 26. .718 1. .00 41. ,22 1SG2118
ATOM 2118 O PRO 269 78. .415 22. .063 25. .808 1. .00 41. .22 1SG2119
ATOM 2119 N PRO 270 79. .276 23. .960 26. ,610 1. .00 40. 99 1SG2120
ATOM 2120 CA PRO 270 79. ,014 24. .752 25. ,441 1. .00 40. 99 1SG2121
ATOM 2121 CD PRO 270 80. ,119 24. .640 27. ,577 1. .00 40. 99 1SG2122
ATOM 2122 CB PRO 270 79. ,476 26. .163 25. .800 1. .00 40. 99 1SG2123
ATOM 2123 CG PRO 270 80. ,571 25. .924 26. 859 1. 00 40. 99 1SG2124
ATOM 2124 C PRO 270 79. .775 24. .196 24. .277 1. .00 40. 99 1SG2125 ATOM 2125 O PRO 270 80..917 23..776 24.,450 1.,00 40..99 1SG2126
ATOM 2126 N ILE 271 79. .182 24, .201 23. .068 1. .00 40. .76 1SG2127
ATOM 2127 CA ILE 271 79. .910 23. .663 21. .959 1. .00 40, .76 1SG2128
ATOM 2128 CB ILE 271 79. .220 22, .537 21. .241 1. .00 40. .76 1SG2129
ATOM 2129 CG2 ILE 271 79, .037 21. .386 22. .243 1. .00 40, .76 1SG2130
ATOM 2130 CGI ILE 271 77, .912 23. .010 20. .589 1. .00 40, .76 1SG2131
ATOM 2131 CDl ILE 271 77, .350 22, .006 19. .582 1. .00 40, .76 1SG2132
ATOM 2132 C ILE 271 80, .137 24, .757 20. .975 1. .00 40. .76 1SG2133
ATOM 2133 O ILE 271 79. .303 25. .647 20. .819 1. .00 40. .76 1SG2134
ATOM 2134 N ILE 272 81, .313 24. .738 20, .316 1. .00 40. .79 1SG2135
ATOM 2135 CA ILE 272 81, .628 25. .740 19. .343 1. .00 40. .79 1SG2136
ATOM 2136 CB ILE 272 82. .772 26. ,624 19. .737 1. .00 40. .79 1SG2137
ATOM 2137 CG2 ILE 272 83, .150 27. .491 18. .523 1. .00 40, .79 1SG2138
ATOM 2138 CGI ILE 272 82, .385 27. .438 20. .984 1. .00 40, .79 1SG2139
ATOM 2139 CDl ILE 272 83, .556 28, .172 21. .633 1. .00 40, .79 1SG2140
ATOM 2140 C ILE 272 81, .962 25, .055 18. .060 1. .00 40, .79 1SG2141
ATOM 2141 O ILE 272 82. .712 24. ,079 18. .029 1. .00 40, .79 1SG2142
ATOM 2142 N ASN 273 81. .386 25. .560 16. .953 1, .00 44, .45 1SG2143
ATOM 2143 CA ASN 273 81. .611 24, .942 15. .684 1. .00 44, .45 1SG2144
ATOM 2144 CB ASN 273 80. .309 24. .616 14. .935 1. .00 44, .45 1SG2145
ATOM 2145 CG ASN 273 79, .580 23. .549 15. .738 1, .00 44, .45 1SG2146
ATOM 2146 ODl ASN 273 80, .200 22. .777 16. .467 1. .00 44, .45 1SG2147
ATOM 2147 ND2 ASN 273 78, .227 23. .503 15. .604 1, .00 44, .45 1SG2148
ATOM 2148 C ASN 273 82, .409 25. .878 14, .833 1. .00 44, .45 1SG2149
ATOM 2149 O ASN 273 82. .154 27. .081 14. .790 1. .00 44. .45 1SG2150
ATOM 2150 N LEU 274 83. .419 25. .323 14, .136 1. .00 52 .19 1SG2151
ATOM 2151 CA LEU 274 84, .269 26. .088 13 , .267 1. .00 52. .19 1SG2152
ATOM 2152 CB LEU 274 85. .758 25. .703 13. .393 1. .00 52. .19 1SG2153
ATOM 2153 CG LEU 274 86, .471 26, .126 14. .690 1. .00 52. .19 1SG2154
ATOM 2154 CD2 LEU 274 85, .653 25, .745 15. .934 1, .00 52, .19 1SG2155
ATOM 2155 CDl LEU 274 86, .845 27, .611 14. .660 1. .00 52 .19 1SG2156
ATOM 2156 C LEU 274 83, .914 25, .733 11, .858 1. .00 52, .19 1SG2157
ATOM 2157 O LEU 274 84, .030 24. .576 11, .457 1. .00 52, .19 1SG2158
ATOM 2158 N GLN 275 83, .479 26. .729 11, .060 1, .00 58 .96 1SG2159
ATOM 2159 CA GLN 275 83. .156 26. .468 9. .686 1, .00 58, .96 1SG2160
ATOM 2160 CB GLN 275 81. .643 26. .369 9. .395 1. .00 58, .96 1SG2161
ATOM 2161 CG GLN 275 80. .905 25. .265 10. .161 1, .00 58, .96 1SG2162
ATOM 2162 CD GLN 275 80. .156 25. .893 11. .333 1. .00 58, .96 1SG2163
ATOM 2163 OEl GLN 275 79. .387 25, .223 12. .021 1. .00 58, .96 1SG2164
ATOM 2164 NE2 GLN 275 80. .368 27. .218 11, .558 1. .00 58, .96 1SG2165
ATOM 2165 C GLN 275 83. .650 27. .640 8. .913 1. .00 58, .96 1SG2166
ATOM 2166 O GLN 275 83. .849 28, .711 9, .482 1. .00 58, .96 1SG2167
ATOM 2167 N PRO 276 83. .867 27. .494 7, .635 1. .00 65, .23 1SG2168
ATOM 2168 CA PRO 276 84. .288 28. .637 6. .890 1. .00 65. .23 1SG2169
ATOM 2169 CD PRO 276 84. .310 26. .248 7. .033 1. .00 65, .23 1SG2170
ATOM 2170 CB PRO 276 84. .629 28. .117 5. .496 1. .00 65. .23 1SG2171
ATOM 2171 CG PRO 276 85, .069 26, .662 5. .756 1. .00 65. .23 1SG2172
ATOM 2172 C PRO 276 83. .124 29. .548 6. .961 1. .00 65, .23 1SG2173
ATOM 2173 0 PRO 276 82. .010 29. .076 6. .790 1. .00 65, .23 1SG2174
ATOM 2174 N GLY 277 83. .320 30. .845 7. .206 1. .00 65, .70 1SG2175
ATOM 2175 CA GLY 277 82. ,179 31. .700 7. .302 1. .00 65. .70 1SG2176
ATOM 2176 C GLY 277 82. .107 32. .221 8. .699 1. .00 65. .70 1SG2177
ATOM 2177 0 GLY 277 81. .970 33. .429 8. .882 1. .00 65. .70 1SG2178
ATOM 2178 N ASN 278 82. .211 31. .345 9. .727 1. .00 62. .39 1SG2179
ATOM 2179 CA ASN 278 82. .168 31. .901 11. .050 1. .00 62. .39 1SG2180
ATOM 2180 CB ASN 278 80. .905 32. ,757 11. .308 1. .00 62. .39 1SG2181
ATOM 2181 CG ASN 278 81. ,151 33. ,743 12. .447 1. ,00 62. .39 1SG2182 ATOM 2182 ODl ASN 278 80..997 33,.435 13..627 1.,00 62,.39 1SG2183
ATOM 2183 ND2 ASN 278 81 .539 34, .994 12. .080 1. .00 62, .39 1SG2184
ATOM 2184 C ASN 278 82, .177 30. .808 12. .077 1. ,00 62. .39 1SG2185
ATOM 2185 O ASN 278 82, .028 29. .626 11. .768 1. .00 62. .39 1SG2186
ATOM 2186 N PHE 279 82, .352 31. .215 13. .350 1. .00 56, .32 1SG2187
ATOM 2187 CA PHE 279 82 .392 30, .340 14. .486 1. .00 56 .32 1SG2188
ATOM 2188 CB PHE 279 83, .374 30. .834 15. .556 1. .00 56, .32 1SG2189
ATOM 2189 CG PHE 279 84, .657 31. .212 14 , .905 1. .00 56. .32 1SG2190
ATOM 2190 CDl PHE 279 85 .660 30, .297 14, .720 1. .00 56, .32 1SG2191
ATOM 2191 CD2 PHE 279 84 .851 32. .506 14. .478 1, .00 56 .32 1SG2192
ATOM 2192 CE1 PHE 279 86, .840 30. .660 14. .118 1. .00 56, .32 1SG2193
ATOM 2193 CE2 PHE 279 86 .027 32, .880 13. .874 1. .00 56, .32 1SG2194
ATOM 2194 CZ PHE 279 87 .024 31, .953 13, .694 1, .00 56 .32 1SG2195
ATOM 2195 C PHE 279 81, .054 30, .490 15. .147 1. .00 56, .32 1SG2196
ATOM 2196 O PHE 279 80, .572 31, .607 15. .333 1. .00 56, .32 1SG2197
ATOM 2197 N THR 280 80 .415 29. .370 15, .534 1. .00 50 .20 1SG2198
ATOM 2198 CA THR 280 79 .130 29. .471 16, .163 1. .00 50 .20 1SG2199
ATOM 2199 CB THR 280 78, .069 28. .722 15. .415 1. .00 50 .20 1SG2200
ATOM 2200 OGl THR 280 77 .974 29. .200 14. .082 1. .00 50 .20 1SG2201
ATOM 2201 CG2 THR 280 76 .735 28. .932 16. .135 1. .00 50 .20 1SG2202
ATOM 2202 C THR 280 79 .248 28 .848 17, .520 1. .00 50 .20 1SG2203
ATOM 2203 O THR 280 79, .976 27. .872 17. .697 1. .00 50 .20 1SG2204
ATOM 2204 N LEU 281 78 .544 29. .415 18. .525 1. .00 46 .03 1SG2205
ATOM 2205 CA LEU 281 78 .611 28, .886 19. .860 1. .00 46 .03 1SG2206
ATOM 2206 CB LEU 281 79, .201 29, .904 20. .866 1. .00 46, .03 1SG2207
ATOM 2207 CG LEU 281 79, .490 29, .393 22. .299 1. .00 46 .03 1SG2208
ATOM 2208 CD2 LEU 281 78 .246 28, .837 23. .011 1. .00 46 .03 1SG2209
ATOM 2209 CDl LEU 281 80 .149 30, .500 23. .136 1. .00 46 .03 1SG2210
ATOM 2210 C LEU 281 77, .214 28. .532 20. .277 1. .00 46 .03 1SG2211
ATOM 2211 O LEU 281 76 .273 29. .277 20, .010 1, .00 46 .03 1SG2212
ATOM 2212 N ASP 282 77 .035 27. .363 20, .932 1. .00 42 .08 1SG2213
ATOM 2213 CA ASP 282 75 .718 27. .003 21, .384 1. .00 42 .08 1SG2214
ATOM 2214 CB ASP 282 75, .170 25. .706 20, .763 1. .00 42 .08 1SG2215
ATOM 2215 CG ASP 282 74. .790 26. .004 19, .319 1. .00 42 .08 1SG2216
ATOM 2216 ODl ASP 282 75 .028 27. .158 18, .871 1. .00 42 .08 1SG2217
ATOM 2217 OD2 ASP 282 74, .246 25. .087 18. .649 1. .00 42, .08 1SG2218
ATOM 2218 C ASP 282 7-5. .739 26. .820 22. .873 1. .00 42, .08 1SG2219
ATOM 2219 O ASP 282 76, .162 25. .781 23. .376 1. .00 42, .08 1SG2220
ATOM 2220 N ILE 283 75 .257 27. .826 23, .630 1. .00 40 .53 1SG2221
ATOM 2221 CA ILE 283 75, .290 27. .700 25, .061 1. .00 40, .53 1SG2222
ATOM 2222 CB ILE 283 75, .927 28. .872 25, .752 1. .00 40, .53 1SG2223
ATOM 2223 CG2 ILE 283 75, .100 30. .131 25, .440 1. .00 40, .53 1SG2224
ATOM 2224 CGI ILE 283 76, .085 28. .578 27, .253 1. .00 40 .53 1SG2225
ATOM 2225 CDl ILE 283 76, .966 29. .587 27, .988 1. .00 40, .53 1SG2226
ATOM 2226 C ILE 283 73, .907 27. .563 25. .616 1. .00 40, .53 1SG2227
ATOM 2227 O ILE 283 73, .013 28. .353 25, .312 1. .00 40, .53 1SG2228
ATOM 2228 N PRO 284 73, .719 26. .482 26. .341 1. ,00 37. .84 1SG2229
ATOM 2229 CA PRO 284 72, .503 26. .280 27, .091 1. .00 37. .84 1SG2230
ATOM 2230 CD PRO 284 74, .272 25. .222 25, .871 1. .00 37, .84 1SG2231
ATOM 2231 CB PRO 284 72, .218 24. .778 27, .058 1. .00 37, .84 1SG2232
ATOM 2232 CG PRO 284 73. .573 24. .143 26. .709 1. .00 37. .84 1SG2233
ATOM 2233 C PRO 284 72. .687 26. .800 28. .486 1. .00 37. .84 1SG2234
ATOM 2234 O PRO 284 73. .806 26. .749 28. .997 1. .00 37, .84 1SG2235
ATOM 2235 N ALA 285 71, .610 27. .264 29. .149 1. .00 34, .53 1SG2236
ATOM 2236 CA ALA 285 71. .775 27. .737 30. ,492 1. ,00 34. .53 1SG2237
ATOM 2237 CB ALA 285 71. .998 29. .256 30. .587 1. ,00 34. .53 1SG2238
ATOM 2238 C ALA 285 70. .518 27. .435 31. .236 1. ,00 34. .53 1SG2239 ATOM 2239 O ALA 285 69..439 27,.359 30..651 1..00 34..53 1SG2240
ATOM 2240 N SER 286 70, .635 27 .244 32. .563 1, .00 34, .20 1SG2241
ATOM 2241 CA SER 286 69, .461 26 .995 33. .338 1. .00 34, .20 1SG2242
ATOM 2242 CB SER 286 69, .570 25, .749 34. .233 1. .00 34. .20 1SG2243
ATOM 2243 OG SER 286 68, .368 25, .566 34. .966 1. .00 34. .20 1SG2244
ATOM 2244 C SER 286 69, .305 28. .189 34. .218 1. .00 34. .20 1SG2245
ATOM 2245 O SER 286 70, .231 28 .572 34. .932 1. .00 34. .20 1SG2246
ATOM 2246 N ILE 287 68, .122 28 .828 34, .169 1. .00 34. .38 1SG2247
ATOM 2247 CA ILE 287 67, .912 29. .988 34, .978 1. .00 34, .38 1SG2248
ATOM 2248 CB ILE 287 67, .526 31. .211 34. .192 1. .00 34, .38 1SG2249
ATOM 2249 CG2 ILE 287 68, .708 31, .575 33. .278 1. .00 34. .38 1SG2250
ATOM 2250 CGI ILE 287 66 .202 30 .996 33, .438 1. .00 34. .38 1SG2251
ATOM 2251 CDl ILE 287 65, .619 32 .281 32, .852 1. .00 34. .38 1SG2252
ATOM 2252 C ILE 287 66, .814 29 .675 35. .941 1, .00 34, .38 1SG2253
ATOM 2253 O ILE 287 65, .706 29, .315 35. .546 1, .00 34, .38 1SG2254
ATOM 2254 N MET 288 67, .108 29, .793 37. .250 1. .00 35, .20 1SG2255
ATOM 2255 CA MET 288 66 .108 29 .510 38, .238 1. .00 35 .20 1SG2256
ATOM 2256 CB MET 288 66 .526 28 .439 39, .260 1, .00 35 .20 1SG2257
ATOM 2257 CG MET 288 66, .686 27 .047 38, .649 1, .00 35 .20 1SG2258
ATOM 2258 SD MET 288 68, .118 26 .877 37, .546 1, .00 35, .20 1SG2259
ATOM 2259 CE MET 288 69, .361 26. .947 38. .865 1, .00 35. .20 1SG2260
ATOM 2260 C MET 288 65 .863 30 .766 39 .003 1 .00 35 .20 1SG2261
ATOM 2261 0 MET 288 66, .791 31 .494 39. .352 1 .00 35 .20 1SG2262
ATOM 2262 N MET 289 64, .582 31 .057 39. .282 1 .00 37 .17 1SG2263
ATOM 2263 CA MET 289 64, .268 32 .254 39. .994 1, .00 37. .17 1SG2264
ATOM 2264 CB MET 289 63. .317 33. .158 39, .186 1. .00 37. .17 1SG2265
ATOM 2265 CG MET 289 62 .239 32 .402 38 .409 1 .00 37 .17 1SG2266
ATOM 2266 SD MET 289 61 .117 33 .467 37, .454 1 .00 37 .17 1SG2267
ATOM 2267 CE MET 289 60, .272 34 .156 38, .906 1, .00 37, .17 1SG2268
ATOM 2268 C MET 289 63, .737 31 .887 41. .342 1, .00 37, .17 1SG2269
ATOM 2269 0 MET 289 62, .936 30, .965 41. .485 1, .00 37, .17 1SG2270
ATOM 2270 N LEU 290 64 .236 32 .583 42. .385 1 .00 38 .24 1SG2271
ATOM 2271 CA LEU 290 63, .842 32 .286 43. .731 1, .00 38, .24 1SG2272
ATOM 2272 CB LEU 290 64, .992 31 .756 44. .606 1, .00 38, .24 1SG2273
ATOM 2273 CG LEU 290 65, .554 30 .403 44, .132 1, .00 38, .24 1SG2274
ATOM 2274 CD2 LEU 290 66, .505 29, .798 45. .176 1. .00 38, .24 1SG2275
ATOM 2275 CDl LEU 290 66 .194 30 .521 42. .739 1, .00 38, .24 1SG2276
ATOM 2276 C LEU 290 63, .354 33 .541 44. .375 1, .00 38, .24 1SG2277
ATOM 2277 O LEU 290 63, .757 34, .644 44, .012 1, .00 38, .24 1SG2278
ATOM 2278 N THR 291 62, .454 33, .396 45. .364 1, .00 40, .07 1SG2279
ATOM 2279 CA THR 291 61, .975 34. .546 46. .064 1. .00 40. .07 1SG2280
ATOM 2280 CB THR 291 60, .510 34 .495 46. .381 1. .00 40. .07 1SG2281
ATOM 2281 OGl THR 291 59, .753 34 .376 45. .185 1. .00 40, .07 1SG2282
ATOM 2282 CG2 THR 291 60. .124 35. .783 47. .126 1. .00 40. .07 1SG2283
ATOM 2283 C THR 291 62. .712 34. .549 47. .355 1. .00 40. .07 1SG2284
ATOM 2284 0 THR 291 62. .954 33. .494 47. .935 1. .00 40. .07 1SG2285
ATOM 2285 N GLN 292 63. .127 35. .737 47. .827 1, .00 45. .42 1SG2286
ATOM 2286 CA GLN 292 63. .869 35, .760 49. .052 1. .00 45. .42 1SG2287
ATOM 2287 CB GLN 292 65. .034 36, .763 49. .045 1. .00 45. .42 1SG2288
ATOM 2288 CG GLN 292 65. .827 36. .785 50. .354 1. .00 45. .42 1SG2289
ATOM 2289 CD GLN 292 66. .942 37. .811 50. .214 1. .00 45. .42 1SG2290
ATOM 2290 OEl GLN 292 67. .080 38. .460 49. .179 1. .00 45. .42 1SG2291
ATOM 2291 NE2 GLN 292 67. .761 37. .966 51. .289 1. .00 45. .42 1SG2292
ATOM 2292 C GLN 292 62. .945 36. .162 50. .157 1. ,00 45. .42 1SG2293
ATOM 2293 O GLN 292 62. .401 37. .264 50. .168 1. ,00 45. ,42 1SG2294
ATOM 2294 N PRO 293 62. ,752 35. .265 51. .085 1. ,00 51. ,44 1SG2295
ATOM 2295 CA PRO 293 61. .950 35. .603 52. ,224 1. .00 51. .44 1SG2296 ATOM 2296 CD PRO 293 62.,519 33..885 50.690 1.00 51.,44 1SG2297
ATOM 2297 CB PRO 293 61. ,555 34. .281 52. ,877 1. 00 51. .44 1SG2298
ATOM 2298 CG PRO 293 61. .503 33. .310 51. .689 1. 00 51. .44 1SG2299
ATOM 2299 C PRO 293 62. .679 36. .536 53. .134 1. .00 51. .44 1SG2300
ATOM 2300 O PRO 293 63. .897 36. .663 53. ,022 1. ,00 51. .44 1SG2301
ATOM 2301 N LYS 294 61. .938 37. .188 54. ,048 1. ,00 56. .42 1SG2302
ATOM 2302 CA LYS 294 62. .493 38. .152 54. , 952 1. ,00 56. .42 1SG2303
ATOM 2303 CB LYS 294 61. .462 38. .701 55. .952 1. .00 56. .42 1SG2304
ATOM 2304 CG LYS 294 60. .891 37. .635 56. .888 1. .00 56, .42 1SG2305
ATOM 2305 CD LYS 294 60. .153 36. .511 56. .160 1. .00 56, .42 1SG2306
ATOM 2306 CE LYS 294 58. .806 36, .941 55. .576 1. .00 56, .42 1SG2307
ATOM 2307 NZ LYS 294 58. .163 35. .798 54. .891 1. .00 56. .42 1SG2308
ATOM 2308 C LYS 294 63. .551 37. .453 55. ,728 1. .00 56. .42 1SG2309
ATOM 2309 O LYS 294 64. .541 38. .056 56. .142 1. .00 56. .42 1SG2310
ATOM 2310 N ASN 295 63. .347 36. .147 55. .952 1. .00 58, .92 1SG2311
ATOM 2311 CA ASN 295 64. .304 35. .377 56. .677 1. .00 58, .92 1SG2312
ATOM 2312 CB ASN 295 63. .881 33. .899 56. .696 1. .00 58, .92 1SG2313
ATOM 2313 CG ASN 295 65. .074 33. .045 57. .063 1. .00 58, .92 1SG2314
ATOM 2314 ODl ASN 295 65. .914 32, .788 56. .203 1. .00 58 .92 1SG2315
ATOM 2315 ND2 ASN 295 65. .153 32, .587 58. .341 1, .00 58 .92 1SG2316
ATOM 2316 C ASN 295 65, .631 35, .500 55, .993 1, .00 58 .92 1SG2317
ATOM 2317 O ASN 295 66, .583 35, .967 56. .612 1, .00 58 .92 1SG2318
ATOM 2318 N SER 296 65, .713 35 .108 54. .701 1, .00 56 .12 1SG2319
ATOM 2319 CA SER 296 66, .906 35, .167 53, .887 1. .00 56 .12 1SG2320
ATOM 2320 CB SER 296 68, .253 35 .140 54, .639 1. .00 56 .12 1SG2321
ATOM 2321 OG SER 296 68, .422 33 .898 55, .306 1, .00 56 .12 1SG2322
ATOM 2322 C SER 296 66. .899 33 , .923 53. .074 1. .00 56, .12 1SG2323
ATOM 2323 O SER 296 67. .666 33, .774 52. .124 1, .00 56 .12 1SG2324
ATOM 2324 N THR 297 66. .011 32, .986 53. .448 1. .00 52 .39 1SG2325
ATOM 2325 CA THR 297 65. .958 31. .731 52, .767 1, .00 52 .39 1SG2326
ATOM 2326 CB THR 297 64. .985 30, .761 53, .372 1, .00 52 .39 1SG2327
ATOM 2327 OGl THR 297 63. .670 31 .295 53, .331 1, .00 52 .39 1SG2328
ATOM 2328 CG2 THR 297 65. .402 30 .472 54, .823 1, .00 52 .39 1SG2329
ATOM 2329 C THR 297 65, .525 32 .008 51, .372 1, .00 52 .39 1SG2330
ATOM 2330 O THR 297 65 .206 33 .143 51. .028 1 .00 52 .39 1SG2331
ATOM 2331 N VAL 298 65, .557 30 .976 50, .509 1 .00 49 .16 1SG2332
ATOM 2332 CA VAL 298 65 .148 31 .197 49, .156 1 .00 49 .16 1SG2333
ATOM 2333 CB VAL 298 66 .255 31 .005 48. .160 1 .00 49 .16 1SG2334
ATOM 2334 CGI VAL 298 67 .349 32 .049 48. .438 1 .00 49 .16 1SG2335
ATOM 2335 CG2 VAL 298 66 .743 29 .549 48 .245 1 .00 49 .16 1SG2336
ATOM 2336 C VAL 298 64 .084 30 .203 48, .821 1 .00 49 .16 1SG2337
ATOM 2337 O VAL 298 64, .193 29 .025 49, .161 1, .00 49 .16 1SG2338
ATOM 2338 N GLU 299 63, .007 30 .659 48, .148 1, .00 47 .18 1SG2339
ATOM 2339 CA GLU 299 62, .001 29 .723 47, .732 1, .00 47 .18 1SG2340
ATOM 2340 CB GLU 299 60, .560 30 .052 48, .156 1, .00 47 .18 1SG2341
ATOM 2341 CG GLU 299 59, .575 28 .987 47. .660 1, .00 47 .18 1SG2342
ATOM 2342 CD GLU 299 58, .161 29 .342 48. .099 1, .00 47 .18 1SG2343
ATOM 2343 OEl GLU 299 57, .850 29 .161 49. .306 1, .00 47 .18 1SG2344
ATOM 2344 OE2 GLU 299 57 .369 29 .788 47. .226 1, .00 47 .18 1SG2345
ATOM 2345 C GLU 299 62 .016 29 .699 46 .237 1, .00 47 .18 1SG2346
ATOM 2346 O GLU 299 61 .916 30 .742 45, .591 1 .00 47 .18 1SG2347
ATOM 2347 N THR 300 62 .140 28 .492 45, .648 1 .00 46 .94 1SG2348
ATOM 2348 CA THR 300 62 .259 28 .364 44 .221 1 .00 46 .94 1SG2349
ATOM 2349 CB THR 300 62 .740 27 .011 43 .788 1 .00 46 .94 1SG2350
ATOM 2350 OGl THR 300 61 .803 26 .014 44 .168 1 .00 46 .94 1SG2351
ATOM 2351 CG2 THR 300 64 .101 26 .738 44 .450 1 .00 46 .94 1SG2352
ATOM 2352 C ' THR 300 60, .942 28, .586 43, .555 1, .00 46. .94 1SG2353 ATOM 2353 O THR 300 60,.004 27..825 43..778 1..00 46..94 1SG2354
ATOM 2354 N ILE 301 60, .822 29. .676 42. .761 1. .00 45, .82 1SG2355
ATOM 2355 CA ILE 301 59, .610 29. .901 42. .030 1. .00 45, .82 1SG2356
ATOM 2356 CB ILE 301 59, .380 31, .341 41. .656 1. .00 45, .82 1SG2357
ATOM 2357 CG2 ILE 301 60. .453 31, .775 40. .656 1. .00 45, .82 1SG2358
ATOM 2358 CGI ILE 301 57 .944 31 .531 41. .142 1. .00 45, .82 1SG2359
ATOM 2359 CDl ILE 301 56 .881 31 .325 42, .220 1. .00 45, .82 1SG2360
ATOM 2360 C ILE 301 59 .497 29, .038 40, .796 1. .00 45, .82 1SG2361
ATOM 2361 O ILE 301 58 .511 28, .319 40. .642 1, .00 45, .82 1SG2362
ATOM 2362 N VAL 302 60. .511 29, .056 39. .892 1, .00 42, .56 1SG2363
ATOM 2363 CA VAL 302 60. .412 28. .324 38. .647 1. .00 42, .56 1SG2364
ATOM 2364 CB VAL 302 59 .622 2 .079 37, .600 1. .00 42 .56 1SG2365
ATOM 2365 CGI VAL 302 59 .550 28 .263 36, .300 1. .00 42, .56 1SG2366
ATOM 2366 CG2 VAL 302 58 .237 29. .445 38, .162 1. .00 42, .56 1SG2367
ATOM 2367 C VAL 302 61. .794 28. .118 38, .072 1, .00 42, .56 1SG2368
ATOM 2368 O VAL 302 62, .730 28. .846 38 , .396 1, .00 42, .56 1SG2369
ATOM 2369 N SER 303 61, .954 27, .108 37. .185 1. .00 38, .64 1SG2370
ATOM 2370 CA SER 303 63. .224 26, .868 36. .547 1. .00 38, .64 1SG2371
ATOM 2371 CB SER 303 63 .772 25 .451 36. .791 1 .00 38 .64 1SG2372
ATOM 2372 OG SER 303 65 .020 25 .290 36. .132 1 .00 38 .64 1SG2373
ATOM 2373 C SER 303 63 .032 27, .022 35. .066 1 .00 38 .64 1SG2374
ATOM 2374 O SER 303 62. .063 26, .521 34. .498 1 .00 38 .64 1SG2375
ATOM 2375 N MET 304 63, .968 27, .725 34. .392 1 .00 35 .32 1SG2376
ATOM 2376 CA MET 304 63, .820 27, .932 32. .979 1. .00 35, .32 1SG2377
ATOM 2377 CB MET 304 63 .736 29 .406 32. .562 1 .00 35 .32 1SG2378
ATOM 2378 CG MET 304 63 .358 29 .568 31. .090 1 .00 35 .32 1SG2379
ATOM 2379 SD MET 304 63, .801 31, .175 30. .379 1 .00 35 .32 1SG2380
ATOM 2380 CE MET 304 65, .568 30. .758 30. .319 1 .00 35 .32 1SG2381
ATOM 2381 C MET 304 65, .014 27. .378 32, .273 1. .00 35 .32 1SG2382
ATOM 2382 O MET 304 66, .124 27, .369 32. .804 1. .00 35, .32 1SG2383
ATOM 2383 N ASP 305 64 , .793 26. .887 31. .037 1. .00 31, .91 1SG2384
ATOM 2384 CA ASP 305 65, .864 26. .362 30, .244 1 .00 31 .91 1SG2385
ATOM 2385 CB ASP 305 65, .588 24. .958 29, .681 1 .00 31 .91 1SG2386
ATOM 2386 CG ASP 305 66, .875 24. .445 29, .050 1 .00 31 .91 1SG2387
ATOM 2387 ODl ASP 305 67, .874 25. .212 29, .039 1 .00 31 .91 1SG2388
ATOM 2388 OD2 ASP 305 66, .875 23. .280 28, .570 1. .00 31, .91 1SG2389
ATOM 2389 C ASP 305 66 , .034 27. .284 29. .081 1. .00 31, .91 1SG2390
ATOM 2390 O ASP 305 65, .127 27. .462 28. .270 1 .00 31 .91 1SG2391
ATOM 2391 N PHE 306 67, .219 27. .909 28, .984 1 .00 30 .98 1SG2392
ATOM 2392 CA PHE 306 67, .499 28, .829 27, .924 1, .00 30, .98 1SG2393
ATOM 2393 CB PHE 306 67. .959 30, .203 28. .439 1, .00 30, .98 1SG2394
ATOM 2394 CG PHE 306 68. .648 30. .867 27. .303 1, .00 30, .98 1SG2395
ATOM 2395 CDl PHE 306 67. .944 31. .447 26. .276 1, .00 30, .98 1SG2396
ATOM 2396 CD2 PHE 306 70. .024 30. ,896 27. .276 1, .00 30. .98 1SG2397
ATOM 2397 CE1 PHE 306 68. .614 32. .048 25. .237 1, .00 30, .98 1SG2398
ATOM 2398 CE2 PHE 306 70, .697 31, .495 26. .241 1, .00 30, .98 1SG2399
ATOM 2399 CZ PHE 306 69. .987 32. .073 25. .218 1, .00 30, .98 1SG2400
ATOM 2400 C PHE 306 68. .595 28. .282 27. .067 1, .00 30, .98 1SG2401
ATOM 2401 O PHE 306 69. .524 27. .639 27. .553 1. .00 30, .98 1SG2402
ATOM 2402 N VAL 307 68. .484 28. .519 25. .745 1. .00 32. .01 1SG2403
ATOM 2403 CA VAL 307 69. .477 28. .110 24. .795 1, .00 32. .01 1SG2404
ATOM 2404 CB VAL 307 69. .171 26. .796 24. .141 1, .00 32. .01 1SG2405
ATOM 2405 CGI VAL 307 67. .846 26. .935 23. .372 1, .00 32. .01 1SG2406
ATOM 2406 CG2 VAL 307 70. .362 26. .403 23. .251 1, .00 32. .01 1SG2407
ATOM 2407 C VAL 307 69. ,462 29. .149 23. .720 1. .00 32. .01 1SG2408
ATOM 2408 O VAL 307 68. ,480 29. ,873 23. ,566 1. .00 32. .01 1SG2409
ATOM 2409 N ALA 308 70. .563 29. .264 22. .952 1, .00 32. .14 1SG2410 ATOM 2410 CA ALA 308 70..600 30..255 21..914 1..00 32..14 1SG2411
ATOM 2411 CB ALA 308 70. .853 31. .682 22. .427 1. .00 32. .14 1SG2412
ATOM 2412 C ALA 308 71, .726 29. .911 20. .996 1. .00 32 , .14 1SG2413
ATOM 2413 O ALA 308 72, .382 28. .887 21. .162 1, .00 32. .14 1SG2414
ATOM 2414 N SER 309 71. .938 30. .760 19. .965 1. .00 34. .35 1SG2415
ATOM 2415 CA SER 309 73. .012 30. .594 19. .027 1. .00 34. .35 1SG2416
ATOM 2416 CB SER 309 72. .531 30. .366 17. .585 1. .00 34 , .35 1SG2417
ATOM 2417 OG SER 309 73, .640 30. .214 16. .713 1. .00 34. .35 1SG2418
ATOM 2418 C SER 309 73. .761 31, .891 19. .047 1, .00 34. .35 1SG2419
ATOM 2419 O SER 309 73. .168 32, .953 19, .218 1. .00 34, .35 1SG2420
ATOM 2420 N THR 310 75, .097 31, .842 18, .886 1. .00 35, .05 1SG2421
ATOM 2421 CA THR 310 75. .850 33. .056 19. .002 1. .00 35. .05 1SG2422
ATOM 2422 CB THR 310 76. .505 33. .157 20. .345 1. .00 35. .05 1SG2423
ATOM 2423 OGl THR 310 77. .448 32. .109 20. .511 1. .00 35. .05 1SG2424
ATOM 2424 CG2 THR 310 75. .417 33. .057 21. .423 1. .00 35. .05 1SG2425
ATOM 2425 C THR 310 76, .970 33. .041 18. .014 1. .00 35. .05 1SG2426
ATOM 2426 O THR 310 77, .335 31. .997 17. .478 1 .00 35 .05 1SG2427
ATOM 2427 N SER 311 77. .558 34. .226 17. .759 1. .00 34 , .17 1SG2428
ATOM 2428 CA SER 311 78, .679 34. .286 16. .873 1, .00 34 , .17 1SG2429
ATOM 2429 CB SER 311 78, .573 35, .401 15. .818 1, .00 34, .17 1SG2430
ATOM 2430 OG SER 311 77, .466 35, .161 14. .961 1, .00 34 .17 1SG2431
ATOM 2431 C SER 311 79, .860 34, .598 17. .726 1, .00 34 .17 1SG2432
ATOM 2432 O SER 311 79, .789 35, .467 18, .594 1 .00 34 .17 1SG2433
ATOM 2433 N VAL 312 80 .981 33, .876 17, .530 1 .00 34 .45 1SG2434
ATOM 2434 CA VAL 312 82, .119 34. .212 18. .329 1, .00 34 , .45 1SG2435
ATOM 2435 CB VAL 312 82, .653 33. .086 19. .174 1, .00 34, .45 1SG2436
ATOM 2436 CGI VAL 312 83, .099 31, .924 18, .276 1, .00 34, .45 1SG2437
ATOM 2437 CG2 VAL 312 83, .774 33, .651 20, .062 1, .00 34 .45 1SG2438
ATOM 2438 C VAL 312 83 .192 34. .716 17, .420 1 .00 34 .45 1SG2439
ATOM 2439 O VAL 312 83 .714 33 .987 16, .577 1 .00 34 .45 1SG2440
ATOM 2440 N GLY 313 83, .528 36. .014 17, .558 1, .00 34 , .15 1SG2441
ATOM 2441 CA GLY 313 84 , .554 36. .591 16, .741 1, .00 34, .15 1SG2442
ATOM 2442 C GLY 313 85, .863 36, .361 17, .423 1, .00 34, .15 1SG2443
ATOM 2443 O GLY 313 85. .924 36, .284 18, .650 1, .00 34, .15 1SG2444
ATOM 2444 N LEU 314 86 .960 36, .262 16, .646 1, .00 35 .91 1SG2445
ATOM 2445 CA LEU 314 88, .222 36, .088 17, .302 1 .00 35 .91 1SG2446
ATOM 2446 CB LEU 314 88 .751 34 .636 17, .274 1 .00 35 .91 1SG2447
ATOM 2447 CG LEU 314 89, .973 34, .360 18. .185 1, .00 35, .91 1SG2448
ATOM 2448 CD2 LEU 314 91, .219 35, .161 17. .774 1, .00 35, .91 1SG2449
ATOM 2449 CDl LEU 314 90, .280 32, .856 18. .245 1, .00 35, .91 1SG2450
ATOM 2450 C LEU 314 89, .218 37, .017 16. .672 1, .00 35, .91 1SG2451
ATOM 2451 O LEU 314 89, .281 37, .150 15. .449 1, .00 35, .91 1SG2452
ATOM 2452 N VAL 315 90, .018 37, .700 17, .522 1, .00 37, .14 1SG2453
ATOM 2453 CA VAL 315 91. .020 38. .634 17. .090 1. .00 37. .14 1SG2454
ATOM 2454 CB VAL 315 90. .571 40. .063 17. .259 1. .00 37. .14 1SG2455
ATOM 2455 CGI VAL 315 91, .672 41. .032 16. .791 1. .00 37. .14 1SG2456
ATOM 2456 CG2 VAL 315 89, .242 40, .234 16. .506 1, .00 37. .14 1SG2457
ATOM 2457 C VAL 315 92, .206 38, .399 17. .985 1. .00 37. .14 1SG2458
ATOM 2458 O VAL 315 92, .104 37, .667 18. .968 1. .00 37. .14 1SG2459
ATOM 2459 N ILE 316 93 .381 38, .975 17, .658 1. .00 40, .57 1SG2460
ATOM 2460 CA ILE 316 94. .517 38. .740 18. .507 1. .00 40. .57 1SG2461
ATOM 2461 CB ILE 316 95. .587 37. .898 17. .858 1. .00 40. .57 1SG2462
ATOM 2462 CG2 ILE 316 94, .960 36. .526 17. .558 1. .00 40. .57 1SG2463
ATOM 2463 CGI ILE 316 96, .198 38. .571 16. .613 1. .00 40. .57 1SG2464
ATOM 2464 CDl ILE 316 97, .215 39. .672 16 , .916 1, .00 40. .57 1SG2465
ATOM 2465 C ILE 316 95, .107 40. .043 18 , .943 1. .00 40. .57 1SG2466
ATOM 2466 O ILE 316 95. .186 41. ,007 18. .181 1. .00 40. ,57 1SG2467 ATOM 2467 N LEU 317 95..505 40..101 20.,228 1..00 44..01 1SG2468
ATOM 2468 CA LEU 317 96, .168 41. .235 20. .796 1. .00 44. .01 1SG2469
ATOM 2469 CB LEU 317 95, .376 41. .925 21. .920 1. .00 44. .01 1SG2470
ATOM 2470 CG LEU 317 96, .103 43. .145 22. .519 1. .00 44. .01 1SG2471
ATOM 2471 CD2 LEU 317 95, .401 43, .643 23. .793 1. .00 44, .01 1SG2472
ATOM 2472 CDl LEU 317 96, .296 44, .254 21. .473 1, .00 44. .01 1SG2473
ATOM 2473 C LEU 317 97, .403 40. .680 21. .409 1. .00 44. .01 1SG2474
ATOM 2474 O LEU 317 97 .346 39, .695 22. .146 1, .00 44, .01 1SG2475
ATOM 2475 N GLY 318 98 .563 41, .287 21, .108 1, .00 49, .20 1SG2476
ATOM 2476 CA GLY 318 99, .768 40. .756 21, .661 1. .00 49. .20 1SG2477
ATOM 2477 C GLY 318 99, .879 39. .343 21. .173 1. .00 49, .20 1SG2478
ATOM 2478 O GLY 318 99 .761 39. .059 19. .982 1, .00 49, .20 1SG2479
ATOM 2479 N GLN 319 100 .197 38, .445 22, .119 1. .00 57, .25 1SG2480
ATOM 2480 CA GLN 319 100, .352 37, .019 22. .013 1, .00 57, .25 1SG2481
ATOM 2481 CB GLN 319 101 .187 36 .458 23, .178 1. .00 57, .25 1SG2482
ATOM 2482 CG GLN 319 102 .558 37, .118 23, .345 1, .00 57, .25 1SG2483
ATOM 2483 CD GLN 319 102, .377 38, .465 24, .034 1, .00 57, .25 1SG2484
ATOM 2484 OEl GLN 319 103, .276 39. .304 24 , .016 1, .00 57, .25 1SG2485
ATOM 2485 NE2 GLN 319 101 .191 38 .678 24 .665 1 .00 57 .25 1SG2486
ATOM 2486 C GLN 319 99 .039 36, .275 22, .071 1 .00 57 .25 1SG2487
ATOM 2487 O GLN 319 98, .968 35, .108 21, .682 1, .00 57, .25 1SG2488
ATOM 2488 N ARG 320 98 .007 36 .899 2 .677 1 .00 60 .83 1SG2489
ATOM 2489 CA ARG 320 96 .782 36, .234 23, .061 1 .00 60 .83 1SG2490
ATOM 2490 CB ARG 320 96, .076 36, .955 24, .220 1, .00 60 .83 1SG2491
ATOM 2491 CG ARG 320 96, .919 37, .031 25, .492 1, .00 60, .83 1SG2492
ATOM 2492 CD ARG 320 96 .260 37 .848 26 .604 1 .00 60 .83 1SG2493
ATOM 2493 NE ARG 320 96 .161 39, .255 26, .122 1, .00 60 .83 1SG2494
ATOM 2494 CZ ARG 320 95. .715 40, .238 26, .958 1. .00 60, .83 1SG2495
ATOM 2495 NHl ARG 320 95 .339 39 .931 28 .234 1 .00 60 .83 1SG2496
ATOM 2496 NH2 ARG 320 95 .648 41, .528 26 .517 1, .00 60 .83 1SG2497
ATOM 2497 C ARG 320 95. .745 36. .075 21, .986 1, .00 60 .83 1SG2498
ATOM 2498 O ARG 320 95. .733 36. .781 20, .979 1, .00 60, .83 1SG2499
ATOM 2499 N LEU 321 94 .834 35 .092 22, .220 1, .00 62 .29 1SG2500
ATOM 2500 CA LEU 321 93 .688 34. .839 21, .389 1, .00 62 .29 1SG2501
ATOM 2501 CB LEU 321 93. .221 33. .378 21, .270 1, .00 62, .29 1SG2502
ATOM 2502 CG LEU 321 94 .262 32 .364 20, .807 1, .00 62 .29 1SG2503
ATOM 2503 CD2 LEU 321 93 .602 31. .036 20, .394 1. .00 62 .29 1SG2504
ATOM 2504 CDl LEU 321 95. .328 32. .190 21, .894 1, .00 62, .29 1SG2505
ATOM 2505 C LEU 321 92, .555 35. .427 22. .160 1, .00 62. .29 1SG2506
ATOM 2506 O LEU 321 92 .267 34. .983 23. .270 1, .00 62. .29 1SG2507
ATOM 2507 N VAL 322 91, .867 36. .429 21. .593 1, .00 59, .45 1SG2508
ATOM 2508 CA VAL 322 90, .781 37, .024 22. .312 1, .00 59, .45 1SG2509
ATOM 2509 CB VAL 322 90 .980 38 .494 22. .566 1, .00 59. .45 1SG2510
ATOM 2510 CGI VAL 322 89, .728 39, .047 23. .235 1, .00 59. .45 1SG2511
ATOM 2511 CG2 VAL 322 92, .226 38. .699 23. .435 1, .00 59. .45 1SG2512
ATOM 2512 C VAL 322 89. .570 36. .870 21. .451 1, .00 59. .45 1SG2513
ATOM 2513 O VAL 322 89. .686 36. .716 20, .237 1, .00 59. .45 1SG2514
ATOM 2514 N CYS 323 88. .369 36. .864 22 , .065 1, .00 53. .24 1SG2515
ATOM 2515 CA CYS 323 87, .181 36. .731 21. .274 1. .00 53. .24 1SG2516
ATOM 2516 CB CYS 323 86 .724 35. .274 21, .091 1, .00 53, .24 1SG2517
ATOM 2517 SG CYS 323 86. .285 34. .479 22. .666 1, .00 53. .24 1SG2518
ATOM 2518 C CYS 323 86. .066 37. .461 21. .949 1, .00 53. .24 1SG2519
ATOM 2519 O CYS 323 86. .208 37. .938 23. .075 1. .00 53. .24 1SG2520
ATOM 2520 N SER 324 84. .922 37. .584 21, .246 1. .00 51. .70 1SG2521
ATOM 2521 CA SER 324 83. .764 38. .213 21. .810 1. .00 51. .70 1SG2522
ATOM 2522 CB SER 324 83. .511 39. .644 21. .307 1. .00 51. ,70 1SG2523
ATOM 2523 OG SER 324 82. .344 40. .175 21. .919 1. .00 51. .70 1SG2524 ATOM 2524 C SER 324 82..589 37..375 21.,423 1.00 51.,70 1SG2525
ATOM 2525 O SER 324 82. 574 36. 740 20. 368 1. 00 51. ,70 1SG2526
ATOM 2526 N LEU 325 81. 569 37. ,352 22. ,298 1. 00 52. 27 1SG2527
ATOM 2527 CA LEU 325 80. .397 36. ,549 22. 115 1. 00 52. ,27 1SG2528
ATOM 2528 CB LEU 325 80. 050 35. .830 23. .438 1. 00 52. ,27 1SG2529
ATOM 2529 CG LEU 325 78. .929 34. ,770 23. ,411 1. .00 52. .27 1SG2530
ATOM 2530 CD2 LEU 325 77. .614 35. .296 22. .821 1. ,00 52. . 21 1SG2531
ATOM 2531 CDl LEU 325 78. .732 34. .172 24. .813 1. ,00 52. . 11 1SG2532
ATOM 2532 C LEU 325 79. .276 37. .496 21. .797 1. ,00 52. .27 1SG2533
ATOM 2533 O LEU 325 79. .122 38. .524 22. .454 1. ,00 52, .27 1SG2534
ATOM 2534 N SER 326 78. .472 37. ,171 20. .762 1. ,00 53. ,41 1SG2535
ATOM 2535 CA SER 326 77. .324 37. .959 20. .398 1. 00 53. .41 1SG2536
ATOM 2536 CB SER 326 77. .401 38. .557 18. .983 1. ,00 53. .41 1SG2537
ATOM 2537 OG SER 326 78. .448 39. .514 18. .914 1. .00 53. .41 1SG2538
ATOM 2538 C SER 326 76. .185 36. ,999 20, .417 1. ,00 53. .41 1SG2539
ATOM 2539 O SER 326 76. .329 35. .857 19. .992 1. .00 53. .41 1SG2540
ATOM 2540 N LEU 327 75. .012 37. .435 20. .903 1. .00 55, .40 1SG2541
ATOM 2541 CA LEU 327 73. .961 36, .489 21, .135 1. .00 55, .40 1SG2542
ATOM 2542 CB LEU 327 73, .485 36, .667 22, .593 1, .00 55 .40 1SG2543
ATOM 2543 CG LEU 327 72. .826 35. .465 23. .286 1. .00 55. .40 1SG2544
ATOM 2544 CD2 LEU 327 73. .852 34. .355 23. .554 1. .00 55. .40 1SG2545
ATOM 2545 CDl LEU 327 71. .571 34. .983 22. .562 1. .00 55, .40 1SG2546
ATOM 2546 C LEU 327 72. .837 36. .802 20. .186 1. .00 55, .40 1SG2547
ATOM 2547 O LEU 327 72. .717 37. .923 19. .696 1. .00 55, .40 1SG2548
ATOM 2548 N ASN 328 71. .990 35, .795 19. .887 1. .00 51 .91 1SG2549
ATOM 2549 CA ASN 328 70. .870 35 .947 18. .999 1. .00 51, .91 1SG2550
ATOM 2550 CB ASN 328 70. .760 34, .826 17, .951 1. .00 51 .91 1SG2551
ATOM 2551 CG ASN 328 70. .534 33 .507 18 .678 1, .00 51 .91 1SG2552
ATOM 2552 ODl ASN 328 70. .757 33, .396 19, .883 1. .00 51. .91 1SG2553
ATOM 2553 ND2 ASN 328 70. .087 32, .469 17, .922 1. .00 51, .91 1SG2554
ATOM 2554 C ASN 328 69. .633 35, .899 19, .843 1. .00 51 .91 1SG2555
ATOM 2555 O ASN 328 69. .667 36, .226 21, .027 1. .00 51. .91 1SG2556
ATOM 2556 N ARG 329 68 .490 35 .519 19. .241 1. .00 48 .55 1SG2557
ATOM 2557 CA ARG 329 67. .266 35, .450 19 .987 1. .00 48 .55 1SG2558
ATOM 2558 CB ARG 329 66 .042 35 .095 19. .124 1, .00 48 .55 1SG2559
ATOM 2559 CG ARG 329 64 .736 35 .028 19 .915 1. .00 48 .55 1SG2560
ATOM 2560 CD ARG 329 64 .270 36 .389 20 .436 1. .00 48 .55 1SG2561
ATOM 2561 NE ARG 329 63 .840 37 .194 19 .259 1, .00 48 .55 1SG2562
ATOM 2562 CZ ARG 329 64. .751 37 .951 18, .580 1. .00 48, .55 1SG2563
ATOM 2563 NHl ARG 329 66. .056 37, .971 18, .980 1. .00 48 .55 1SG2564
ATOM 2564 NH2 ARG 329 64. .357 38 .687 17 .500 1. .00 48, .55 1SG2565
ATOM 2565 C ARG 329 67 .430 34 .383 21, .025 1, .00 48 .55 1SG2566
ATOM 2566 0 ARG 329 68. .168 33 .419 20 .829 1. .00 48 .55 1SG2567
ATOM 2567 N PHE 330 66 .748 34 .548 22, .177 1. .00 44 .59 1SG2568
ATOM 2568 CA PHE 330 66 .873 33 .625 23 .269 1. .00 4 .59 1SG2569
ATOM 2569 CB PHE 330 66 .861 34 .338 24 .633 1, .00 44 .59 1SG2570
ATOM 2570 CG PHE 330 67 .992 35 .310 24 .664 1, .00 44 .59 1SG2571
ATOM 2571 CDl PHE 330 69. .252 34 .922 25 .057 1. .00 44 .59 1SG2572
ATOM 2572 CD2 PHE 330 67. .788 36 .620 24 .298 1. .00 44 .59 1SG2573
ATOM 2573 CE1 PHE 330 70 .290 35 .824 25 .084 1. .00 44 .59 1SG2574
ATOM 2574 CE2 PHE 330 68. .822 37 .527 24 .322 1. .00 44 .59 1SG2575
ATOM 2575 CZ PHE 330 70 .076 37 .130 24 .716 1. .00 44, .59 1SG2576
ATOM 2576 C PHE 330 65 .665 32 .740 23 .253 1 .00 44 .59 1SG2577
ATOM 2577 0 PHE 330 64 .555 33 .194 22 .981 1. .00 44 .59 1SG2578
ATOM 2578 N ARG 331 65 .853 31 .436 23 .542 1 .00 41 .12 1SG2579
ATOM 2579 CA ARG 331 64, .745 30 .523 23 .545 1. .00 41 .12 1SG2580
ATOM 2580 CB ARG 331 64, .991 29 .260 22, .703 1, .00 41, .12 1SG2581 ATOM 2581 CG ARG 331 63..814 28..283 22..707 1..00 41,.12 1SG2582
ATOM 2582 CD ARG 331 64. .062 27. .028 21. .868 1. ,00 41. .12 1SG2583
ATOM 2583 NE ARG 331 64. .123 27. .455 20. .441 1. .00 41. .12 1SG2584
ATOM 2584 CZ ARG 331 62. .978 27. .508 19 .700 1. .00 41. .12 1SG2585
ATOM 2585 NHl ARG 331 61. .785 27, .158 20. .263 1. .00 41. .12 1SG2586
ATOM 2586 NH2 ARG 331 63. .025 27, .914 18. .397 1. .00 41. .12 1SG2587
ATOM 2587 C ARG 331 64. .518 30, .087 24. .954 1. .00 41. .12 1SG2588
ATOM 2588 O ARG 331 65. .452 29, .701 25 .656 1. .00 41. .12 1SG2589
ATOM 2589 N LEU 332 63. .248 30, .141 25. .404 1. .00 41, .33 1SG2590
ATOM 2590 CA LEU 332 62. .948 29, .785 26. .757 1. .00 41, .33 1SG2591
ATOM 2591 CB LEU 332 61. .986 30, .760 27. .455 1. .00 41, .33 1SG2592
ATOM 2592 CG LEU 332 62. .343 32. .240 27. .249 1. .00 41. .33 1SG2593
ATOM 2593 CD2 LEU 332 61. .983 32, .702 25 .833 1. .00 41, .33 1SG2594
ATOM 2594 CDl LEU 332 63. .799 32, .532 27. .621 1. .00 41, .33 1SG2595
ATOM 2595 C LEU 332 62. .211 28. .487 26, .728 1. .00 41, .33 1SG2596
ATOM 2596 O LEU 332 61. .568 28. .141 25, .737 1. .00 41, .33 1SG2597
ATOM 2597 N ALA 333 62. .315 27. .726 27 .833 1. .00 39 .66 1SG2598
ATOM 2598 CA ALA 333 61. .596 26, .498 27 .990 1. .00 39, .66 1SG2599
ATOM 2599 CB ALA 333 62. .419 25, .247 27, .637 1. .00 39, .66 1SG2600
ATOM 2600 C ALA 333 61. .283 26, .427 29, .449 1. .00 39, .66 1SG2601
ATOM 2601 O ALA 333 62. .066 26 .899 30 .272 1, .00 39 .66 1SG2602
ATOM 2602 N LEU 334 60. .125 25 .845 29 .815 1, .00 39 .95 1SG2603
ATOM 2603 CA LEU 334 59. .771 25, .795 31, .206 1. .00 39, .95 1SG2604
ATOM 2604 CB LEU 334 58. .295 26, .163 31, .442 1. .00 39, .95 1SG2605
ATOM 2605 CG LEU 334 57. .869 26 .181 32 .919 1. .00 39 .95 1SG2606
ATOM 2606 CD2 LEU 334 56. .339 26, .243 33 .057 1. .00 39 .95 1SG2607
ATOM 2607 CDl LEU 334 58. .581 27, .308 33 .683 1. .00 39 .95 1SG2608
ATOM 2608 C LEU 334 59. .971 24, .386 31, .685 1. .00 39. .95 1SG2609
ATOM 2609 O LEU 334 59, .265 23 .475 31 .259 1. .00 39 .95 1SG2610
ATOM 2610 N PRO 335 60, .993 24, .172 32 .480 1. .00 42 .35 1SG2611
ATOM 2611 CA PRO 335 61. .210 22, .869 33 .060 1. .00 42 .35 1SG2612
ATOM 2612 CD PRO 335 62. .250 24, .858 32, .219 1. .00 42, .35 1SG2613
ATOM 2613 CB PRO 335 62, .675 22 .836 33 .494 1. .00 42 .35 1SG2614
ATOM 2614 CG PRO 335 63, .356 23, .842 32, .550 1, .00 42 .35 1SG2615
ATOM 2615 C PRO 335 60. .268 22, .459 34, .154 1, .00 42, .35 1SG2616
ATOM 2616 O PRO 335 59. .806 21, .319 34 , .140 1. .00 42, .35 1SG2617
ATOM 2617 N GLU 336 59. .978 23 .363 35 .115 1. .00 46 .36 1SG2618
ATOM 2618 CA GLU 336 59. .113 23, .042 36, .216 1, .00 46 .36 1SG2619
ATOM 2619 CB GLU 336 59. .753 22, .131 37, .279 1. .00 46, .36 1SG2620
ATOM 2620 CG GLU 336 59. .994 20, .696 36. .807 1. .00 46, .36 1SG2621
ATOM 2621 CD GLU 336 60. .625 19, .926 37. .959 1. .00 46 .36 1SG2622
ATOM 2622 OEl GLU 336 60. .835 20, .544 39, .037 1. .00 46 .36 1SG2623
ATOM 2623 OE2 GLU 336 60. .904 18, .711 37, .777 1. .00 46, .36 1SG2624
ATOM 2624 C GLU 336 58. .782 24, .327 36. .901 1. .00 46, .36 1SG2625
ATOM 2625 O GLU 336 59. .577 25, .268 36. .885 1. .00 46, .36 1SG2626
ATOM 2626 N SER 337 57. .588 24, .408 37. .520 1. .00 53, .02 1SG2627
ATOM 2627 CA SER 337 57. .245 25, .636 38. .165 1. .00 53, .02 1SG2628
ATOM 2628 CB SER 337 56. .344 26, .527 37. .297 1. .00 53, .02 1SG2629
ATOM 2629 OG SER 337 56. .039 27. .726 37. .987 1. .00 53. .02 1SG2630
ATOM 2630 C SER 337 56. .492 25. .329 39. .416 1. .00 53. .02 1SG2631
ATOM 2631 O SER 337 55. .572 24. .513 39. .425 1. .00 53, .02 1SG2632
ATOM 2632 N ASN 338 56. .897 25. .969 40. .527 1. .00 60. .22 1SG2633
ATOM 2633 CA ASN 338 56. .217 25. .818 41. .786 1. ,00 60. .22 1SG2634
ATOM 2634 CB ASN 338 57. .018 26. .265 43. .062 1. .00 60, .22 1SG2635
ATOM 2635 CG ASN 338 57. .358 27, .766 43. .095 1. .00 60, .22 1SG2636
ATOM 2636 ODl ASN 338 57. .950 26. .748 42. .745 1. .00 60. .22 1SG2637
ATOM 2637 ND2 ASN 338 56. .216 28. .122 43. .741 1. ,00 60. .22 1SG2638 ATOM 2638 C ASN 338 54..933 26..589 41..717 1..00 60..22 1SG2639
ATOM 2639 O ASN 338 53, .921 26, .192 42. .292 1. .00 60. .22 1SG2640
ATOM 2640 N ARG 339 54, .977 27, .747 41, .029 1. .00 63, .16 1SG2641
ATOM 2641 CA ARG 339 53. .891 28, .681 40, .929 1. .00 63, .16 1SG2642
ATOM 2642 CB ARG 339 54. .307 30, .066 40. .388 1. .00 63. .16 1SG2643
ATOM 2643 CG ARG 339 54, .911 30, .060 38. .986 1, .00 63. .16 1SG2644
ATOM 2644 CD ARG 339 55, .524 31, .403 38, .582 1, .00 63, .16 1SG2645
ATOM 2645 NE ARG 339 56. .176 31 .219 37, .255 1. .00 63, .16 1SG2646
ATOM 2646 CZ ARG 339 57. .202 32, .040 36. .881 1. .00 63. .16 1SG2647
ATOM 2647 NHl ARG 339 57, .628 33, .025 37. .724 1. .00 63. .16 1SG2648
ATOM 2648 NH2 ARG 339 57, .802 31, .875 35. .666 1. .00 63. .16 1SG2649
ATOM 2649 C ARG 339 52 .740 28 .174 40 .121 1 .00 63 .16 1SG2650
ATOM 2650 O ARG 339 51 .625 28 .622 40. .357 1. .00 63 .16 1SG2651
ATOM 2651 N SER 340 52 .982 27 .319 39. .106 1. .00 60. .11 1SG2652
ATOM 2652 CA SER 340 51 .985 26 .698 38 .260 1 .00 60. .11 1SG2653
ATOM 2653 CB SER 340 50 .539 27 .234 38 .306 1 .00 60 .11 1SG2654
ATOM 2654 OG SER 340 50, .501 28 .572 37. .832 1 .00 60 .11 1SG2655
ATOM 2655 C SER 340 52 .440 26 .917 36. .865 1. .00 60. .11 1SG2656
ATOM 2656 O SER 340 53 .436 27 .599 36 .631 1, .00 60. .11 1SG2657
ATOM 2657 N ASN 341 51 .709 26 .343 35 .894 1 .00 54, .59 1SG2658
ATOM 2658 CA ASN 341 52, .103 26 .504 34, .528 1 .00 54, .59 1SG2659
ATOM 2659 CB ASN 341 51, .454 25 .477 33, .582 1, .00 54, .59 1SG2660
ATOM 2660 CG ASN 341 52. .151 25 .542 32 .229 1. .00 54, .59 1SG2661
ATOM 2661 ODl ASN 341 52 .984 26 .411 31 .975 1 .00 54. .59 1SG2662
ATOM 2662 ND2 ASN 341 51, .796 24, .591 31 .324 1 .00 54, .59 1SG2663
ATOM 2663 C ASN 341 51, .683 27, .868 34. .083 1, .00 54. .59 1SG2664
ATOM 2664 O ASN 341 50, .569 28, .311 34. .358 1, .00 54. .59 1SG2665
ATOM 2665 N ILE 342 52 .593 28 .581 33 .392 1 .00 47 .72 1SG2666
ATOM 2666 CA ILE 342 52 .283 29 .872 32 .859 1 .00 47 .72 1SG2667
ATOM 2667 CB ILE 342 52 .674 31 .020 33 .741 1, .00 47. .72 1SG2668
ATOM 2668 CG2 ILE 342 54 .209 31 .092 33 .796 1 .00 47, .72 1SG2669
ATOM 2669 CGI ILE 342 51 .996 32 .307 33 .241 1 .00 47 .72 1SG2670
ATOM 2670 CDl ILE 342 52 .013 33 .451 34 .251 1 .00 47 .72 1SG2671
ATOM 2671 C ILE 342 53, .006 30 .010 31. .557 1, .00 47, .72 1SG2672
ATOM 2672 O ILE 342 53 .831 29 .172 31 .194 1, .00 47, .72 1SG2673
ATOM 2673 N GLU 343 52 .686 31 .072 30 .795 1, .00 43, .18 1SG2674
ATOM 2674 CA GLU 343 53 .337 31 .242 29 .530 1 .00 43, .18 1SG2675
ATOM 2675 CB GLU 343 52, .756 32, .394 28. .691 1, .00 43 , .18 1SG2676
ATOM 2676 CG GLU 343 51, .328 32, .133 28, .211 1, .00 43. .18 1SG2677
ATOM 2677 CD GLU 343 51, .379 30, .993 27. .204 1, .00 43. .18 1SG2678
ATOM 2678 OEl GLU 343 52 .503 30, .491 26. .936 1, .00 43. .18 1SG2679
ATOM 2679 OE2 GLU 343 50. .295 30, .609 26. .689 1, .00 43. .18 1SG2680
ATOM 2680 C GLU 343 54 .779 31 .546 29 .790 1, .00 43. .18 1SG2681
ATOM 2681 O GLU 343 55 .128 32 .515 30 .461 1, .00 43. .18 1SG2682
ATOM 2682 N VAL 344 55 .657 30 .706 29 .221 1, .00 43, .30 1SG2683
ATOM 2683 CA VAL 344 57. .082 30, .814 29 .349 1 .00 43, .30 1SG2684
ATOM 2684 CB VAL 344 57, .822 29, .709 28, .657 1, .00 43. .30 1SG2685
ATOM 2685 CGI VAL 344 59, .325 30, .000 28, .761 1, .00 43. .30 1SG2686
ATOM 2686 CG2 VAL 344 57, .415 28 .365 29 .273 1, .00 43. .30 1SG2687
ATOM 2687 C VAL 344 57. .518 32 .085 28 .692 1, .00 43. .30 1SG2688
ATOM 2688 O VAL 344 58. .574 32. .628 29, .010 1. .00 43. ,30 1SG2689
ATOM 2689 N LEU 345 56. .715 32. .551 27, .719 1. .00 44. ,06 1SG2690
ATOM 2690 CA LEU 345 56. .976 33. .691 26, .884 1. .00 44. .06 1SG2691
ATOM 2691 CB LEU 345 55. .898 33, .890 25. .804 1. .00 44. .06 1SG2692
ATOM 2692 CG LEU 345 55. .820 32. .732 24. .791 1. .00 44. .06 1SG2693
ATOM 2693 CD2 LEU 345 55. .426 31. .413 25. .474 1. .00 44. 06 1SG2694
ATOM 2694 CDl LEU 345 57. .115 32. .620 23. .971 1. ,00 44. 06 1SG2695 ATOM 2695 C LEU 345 57..050 34,.967 27,.674 1..00 44..06 1SG2696
ATOM 2696 O LEU 345 57, .744 35 .898 27. .272 1. .00 44. .06 1SG2697
ATOM 2697 N ARG 346 56, .321 35 .069 28. .799 1. .00 44. .79 1SG2698
ATOM 2698 CA ARG 346 56, .255 36 .296 29 .550 1. .00 44. .79 1SG2699
ATOM 2699 CB ARG 346 55, .320 36 .200 30. .767 1. .00 44. .79 1SG2700
ATOM 2700 CG ARG 346 53, .858 35 .966 30. .380 1. .00 44, .79 1SG2701
ATOM 2701 CD ARG 346 52, .884 36 .018 31 .559 1. .00 44, .79 1SG2702
ATOM 2702 NE ARG 346 52, .613 37 .454 31 .853 1. .00 44, .79 1SG2703
ATOM 2703 CZ ARG 346 51, .402 37 .828 32. .361 1. .00 44. .79 1SG2704
ATOM 2704 NHl ARG 346 50, .444 36, .887 32. .601 1. .00 44. .79 1SG2705
ATOM 2705 NH2 ARG 346 51. .148 39, .143 32, .624 1. .00 44. .79 1SG2706
ATOM 2706 C ARG 346 57, .615 36, .709 30, .047 1. .00 44. .79 1SG2707
ATOM 2707 O ARG 346 57, .886 37, .899 30, .198 1. .00 44, .79 1SG2708
ATOM 2708 N PHE 347 58, .479 35, .725 30. .347 1. .00 48. .40 1SG2709
ATOM 2709 CA PHE 347 59, .798 35, .862 30, .911 1. .00 48. .40 1SG2710
ATOM 2710 CB PHE 347 60, .335 34, .498 31, .393 1. .00 48, .40 1SG2711
ATOM 2711 CG PHE 347 61, .344 34 , .705 32, .475 1. .00 48, .40 1SG2712
ATOM 2712 CDl PHE 347 60, .945 35, .214 33, .691 1. .00 48, .40 1SG2713
ATOM 2713 CD2 PHE 347 62, .663 34, .352 32 , .314 1. .00 48, .40 1SG2714
ATOM 2714 CE1 PHE 347 61, .850 35, .403 34 , .709 1. .00 48. .40 1SG2715
ATOM 2715 CE2 PHE 347 63. .574 34 , .536 33 , .327 1. .00 48. .40 1SG2716
ATOM 2716 CZ PHE 347 63, .169 35, .067 34, .528 1. .00 48. .40 1SG2717
ATOM 2717 C PHE 347 60 .751 36 .459 29 .915 1. .00 48 .40 1SG2718
ATOM 2718 O PHE 347 61 .790 36 .998 30 .295 1. .00 48 .40 1SG2719
ATOM 2719 N GLU 348 60 .442 36 .352 28 .609 1. .00 50 .39 1SG2720
ATOM 2720 CA GLU 348 61 .343 36 .738 27 .557 1. .00 50. .39 1SG2721
ATOM 2721 CB GLU 348 60 .712 36 .623 26, .161 1. .00 50 .39 1SG2722
ATOM 2722 CG GLU 348 60 .386 35, .181 25, .771 1. .00 50, .39 1SG2723
ATOM 2723 CD GLU 348 59 .846 35 .186 24, .352 1. .00 50, .39 1SG2724
ATOM 2724 OEl GLU 348 59, .849 36, .278 23, .724 1. .00 50, .39 1SG2725
ATOM 2725 OE2 GLU 348 59 .428 34 .097 23, .873 1. .00 50, .39 1SG2726
ATOM 2726 C GLU 348 61, .824 38, .149 27, .715 1. .00 50, .39 1SG2727
ATOM 2727 O GLU 348 63 .003 38, .415 27, .491 1. .00 50, .39 1SG2728
ATOM 2728 N ASN 349 60. .952 39, .100 28, .095 1. .00 53, .24 1SG2729
ATOM 2729 CA ASN 349 61. .408 40, .458 28, .209 1, .00 53, .24 1SG2730
ATOM 2730 CB ASN 349 60. .317 41, .430 28, .688 1, .00 53, .24 1SG2731
ATOM 2731 CG ASN 349 59. .287 41, .579 27, .580 1. .00 53, .24 1SG2732
ATOM 2732 ODl ASN 349 59. .629 41, .833 26, .426 1. .00 53 , .24 1SG2733
ATOM 2733 ND2 ASN 349 57. .986 41, .411 27, .937 1. .00 53, .24 1SG2734
ATOM 2734 C ASN 349 62. .482 40, .521 29. .241 1. .00 53 , .24 1SG2735
ATOM 2735 O ASN 349 63. .514 41. .157 29. .030 1. .00 53. .24 1SG2736
ATOM 2736 N ILE 350 62 , .274 39. .875 30. .403 1. .00 57. .03 1SG2737
ATOM 2737 CA ILE 350 63, .289 40. .007 31. .399 1. .00 57. .03 1SG2738
ATOM 2738 CB ILE 350 62, .973 39. .489 32. .781 1. .00 57. .03 1SG2739
ATOM 2739 CG2 ILE 350 61, .670 40. .156 33. .216 1. .00 57. .03 1SG2740
ATOM 2740 CGI ILE 350 62, .949 37, .962 32. .889 1. .00 57. .03 1SG2741
ATOM 2741 CDl ILE 350 64, .343 37, .375 33. .112 1. .00 57, .03 1SG2742
ATOM 2742 C ILE 350 64, .516 39, .313 30. .912 1. .00 57. .03 1SG2743
ATOM 2743 0 ILE 350 65, .621 39, .808 31, .120 1. .00 57. .03 1SG2744
ATOM 2744 N LEU 351 64, .365 38. .140 30. .257 1. .00 57. .12 1SG2745
ATOM 2745 CA LEU 351 65, .545 37. .428 29. .853 1. .00 57. .12 1SG2746
ATOM 2746 CB LEU 351 65, .389 36. .088 29. .107 1. ,00 57. .12 1SG2747
ATOM 2747 CG LEU 351 64. .704 34. .942 29. .858 1. ,00 57. .12 1SG2748
ATOM 2748 CD2 LEU 351 65. .513 33. .645 29. .737 1. ,00 57. .12 1SG2749
ATOM 2749 CDl LEU 351 63. .224 34. .825 29. .470 1. ,00 57. .12 1SG2750
ATOM 2750 C LEU 351 66. .310 38. .259 28. .884 1. ,00 57. .12 1SG2751
ATOM 2751 0 LEU 351 67. .536 38. ,190 28. .844 1. ,00 57. .12 1SG2752
5i : ATOM 2752 N SER 352 65,.606 39..028 28..038 1..00 57..38 1SG2753
ATOM 2753 CA SER 352 66 .282 39, .779 27, .025 1. .00 57. .38 1SG2754
ATOM 2754 CB SER 352 65, .326 40, .513 26, .066 1. .00 57. .38 1SG2755
ATOM 2755 OG SER 352 64 .647 41, .557 26, .748 1. .00 57, .38 1SG2756
ATOM 2756 C SER 352 67 .177 40, .803 27, .638 1. .00 57, .38 1SG2757
ATOM 2757 O SER 352 68 .247 41, .064 27 .101 1. .00 57, .38 1SG2758
ATOM 2758 N SER 353 66 .747 41, .462 28 .731 1, .00 57, .41 1SG2759
ATOM 2759 CA SER 353 67. .562 42. .468 29, .359 1. .00 57. .41 1SG2760
ATOM 2760 CB SER 353 66 .746 43. .405 30, .261 1. .00 57. .41 1SG2761
ATOM 2761 OG SER 353 66 .184 42. .662 31, .330 1. .00 57. .41 1SG2762
ATOM 2762 C SER 353 68 .655 41, .875 30 .201 1, .00 57. .41 1SG2763
ATOM 2763 O SER 353 69 .826 42. .224 30, .065 1, .00 57, .41 1SG2764
ATOM 2764 N ILE 354 68 .281 40, .936 31 .091 1. .00 57, .43 1SG2765
ATOM 2765 CA ILE 354 69 .155 40, .405 32, .096 1. .00 57, .43 1SG2766
ATOM 2766 CB ILE 354 68 .384 39, .480 33 .015 1, .00 57 .43 1SG2767
ATOM 2767 CG2 ILE 354 68 .143 38, .140 32 , .304 1, .00 57, .43 1SG2768
ATOM 2768 CGI ILE 354 69 .076 39. .304 34, .367 1. .00 57, .43 1SG2769
ATOM 2769 CDl ILE 354 70 .367 38. .508 34, .275 1, .00 57 .43 1SG2770
ATOM 2770 C ILE 354 70. .332 39. .726 31, .462 1, .00 57, .43 1SG2771
ATOM 2771 O ILE 354 71 .471 39. .954 31, .867 1 .00 57 .43 1SG2772
ATOM 2772 N LEU 355 70 .107 38, .896 30, .428 1, .00 54, .70 1SG2773
ATOM 2773 CA LEU 355 71 .197 38, .161 29 .858 1, .00 54 .70 1SG2774
ATOM 2774 CB LEU 355 70 .723 37, .167 28, .775 1, .00 54, .70 1SG2775
ATOM 2775 CG LEU 355 71 .816 36, .255 28 .173 1, .00 54 .70 1SG2776
ATOM 2776 CD2 LEU 355 72 .545 35, .474 29, .278 1, .00 54 .70 1SG2777
ATOM 2777 CDl LEU 355 72, .781 37. .009 27, .242 1. .00 54, .70 1SG2778
ATOM 2778 C LEU 355 72 .218 39. .078 29, .250 1, .00 54, .70 1SG2779
ATOM 2779 O LEU 355 73 .397 39. .000 29, .590 1. .00 54, .70 1SG2780
ATOM 2780 N HIS 356 71 .812 39. .981 28, .337 1. .00 51 .58 1SG2781
ATOM 2781 CA HIS 356 72 .816 40. .780 27. .692 1, .00 51, .58 1SG2782
ATOM 2782 NDl HIS 356 70 .187 42, .777 26 .497 1, .00 51 .58 1SG2783
ATOM 2783 CG HIS 356 71 .561 42. .731 26. .560 1, .00 51, .58 1SG2784
ATOM 2784 CB HIS 356 72 .371 41. .483 26. .393 1. .00 51 .58 1SG2785
ATOM 2785 NE2 HIS 356 70 .878 44 , .867 26, .805 1. .00 51, .58 1SG2786
ATOM 2786 CD2 HIS 356 71. .967 44. .016 26. .751 1. ,00 51, .58 1SG2787
ATOM 2787 CE1 HIS 356 69 .831 44. .076 26. .648 1. .00 51, .58 1SG2788
ATOM 2788 C HIS 356 73. .395 41. .794 28. .627 1. ,00 51. .58 1SG2789
ATOM 2789 O HIS 356 74 .585 42, .086 28. .549 1. .00 51, .58 1SG2790
ATOM 2790 N PHE 357 72. .578 42. .425 29. .493 1. ,00 49, .24 1SG2791
ATOM 2791 CA PHE 357 73 .168 43. .399 30. .368 1. ,00 49 .24 1SG2792
ATOM 2792 CB PHE 357 72. .155 44. .220 31. .191 1. .00 49, .24 1SG2793
ATOM 2793 CG PHE 357 71, .437 45. .206 30, .336 1, .00 49, .24 1SG2794
ATOM 2794 CDl PHE 357 72 .032 46. .406 30, .019 1. ,00 49, .24 1SG2795
ATOM 2795 CD2 PHE 357 70, .176 44. .941 29. .855 1. .00 49. .24 1SG2796
ATOM 2796 CE1 PHE 357 71, .380 47. .329 29. .236 1. .00 49, .24 1SG2797
ATOM 2797 CE2 PHE 357 69, .518 45. ,862 29. .074 1, ,00 49. .24 1SG2798
ATOM 2798 CZ PHE 357 70, .120 47. .057 28. .762 1, .00 49. .24 1SG2799
ATOM 2799 C PHE 357 74, .043 42. .757 31. .401 1. .00 49. .24 1SG2800
ATOM 2800 0 PHE 357 75, .209 43. .117 31. .542 1. .00 49. .24 1SG2801
ATOM 2801 N GLY 358 73, .462 41. .844 32. .208 1. .00 45, .36 1SG2802
ATOM 2802 CA GLY 358 74 , .174 41. ,229 33. ,296 1. ,00 45. .36 1SG2803
ATOM 2803 C GLY 358 75, .112 40. .106 32. .944 1. .00 45. .36 1SG2804
ATOM 2804 O GLY 358 76, .265 40. ,110 33. ,364 1. ,00 45. .36 1SG2805
ATOM 2805 N VAL 359 74. .604 39. ,081 32. .226 1. .00 44. .38 1SG2806
ATOM 2806 CA VAL 359 75. .327 37. ,856 31. .979 1. .00 44. .38 1SG2807
ATOM 2807 CB VAL 359 74, .415 36. ,747 31. .542 1. .00 44. .38 1SG2808
ATOM 2808 CGI VAL 359 75. .258 35. ,484 31. ,295 1. ,00 44. ,38 1SG2809 ATOM 2809 CG2 VAL 359 73.,317 36..571 32..607 1..00 44.,38 1SG2810
ATOM 2810 C VAL 359 76. .436 37. ,927 30. .971 1. ,00 44. ,38 1SG2811
ATOM 2811 O VAL 359 77. .571 37. ,544 31. ,247 1. ,00 44. .38 1SG2812
ATOM 2812 N LEU 360 76. .135 38. ,435 29. ,766 1. .00 43. .09 1SG2813
ATOM 2813 CA LEU 360 77. .050 38. .372 28. .662 1. .00 43. .09 1SG2814
ATOM 2814 CB LEU 360 76. .408 38. .922 27. .369 1. .00 43. .09 1SG2815
ATOM 2815 CG LEU 360 77. .106 38. .521 26. .049 1. .00 43. .09 1SG2816
ATOM 2816 CD2 LEU 360 78. .607 38. .832 26. .054 1. .00 43 , .09 1SG2817
ATOM 2817 CDl LEU 360 76, .380 39. .127 24. .837 1. .00 43. .09 1SG2818
ATOM 2818 C LEU 360 78, .304 39. .130 28, .983 1. .00 43. .09 1SG2819
ATOM 2819 O LEU 360 79, .390 38. .641 28, .676 1. .00 43, .09 1SG2820
ATOM 2820 N PRO 361 78. .231 40. .275 29, .611 1. .00 40, .51 1SG2821
ATOM 2821 CA PRO 361 79, .426 41. .029 29. .865 1. .00 40. .51 1SG2822
ATOM 2822 CD PRO 361 77, .080 41. .152 29. .473 1. .00 40. .51 1SG2823
ATOM 2823 CB PRO 361 78. .963 42. .378 30. .402 1. .00 40. .51 1SG2824
ATOM 2824 CG PRO 361 77. .602 42. .578 29. .714 1. .00 40. .51 1SG2825
ATOM 2825 C PRO 361 80, .458 40. .345 30. .703 1. .00 40. .51 1SG2826
ATOM 2826 O PRO 361 81, .643 40. .572 30. .466 1. .00 40, .51 1SG2827
ATOM 2827 N LEU 362 80, .062 39. .533 31. .697 1, .00 37, .86 1SG2828
ATOM 2828 CA LEU 362 81, .064 38. .887 32. .490 1, .00 37, .86 1SG2829
ATOM 2829 CB LEU 362 80. .492 38. .148 33, .713 1, .00 37 .86 1SG2830
ATOM 2830 CG LEU 362 79, .964 39. .095 34, .807 1, .00 37 .86 1SG2831
ATOM 2831 CD2 LEU 362 78, .852 40. .006 34, .270 1, .00 37 .86 1SG2832
ATOM 2832 CDl LEU 362 81, .110 39. .888 35, .457 1. .00 37 .86 1SG2833
ATOM 2833 C LEU 362 81 .791 37, .888 31, .647 1. .00 37 .86 1SG2834
ATOM 2834 O LEU 362 83 .014 37, .780 31, .716 1. .00 37 .86 1SG2835
ATOM 2835 N ALA 363 81 .045 37. .126 30, .824 1 .00 36 .15 1SG2836
ATOM 2836 CA ALA 363 81, .624 36. .077 30. .035 1, .00 36, .15 1SG2837
ATOM 2837 CB ALA 363 80, .568 35. .285 29. .245 1. .00 36, .15 1SG2838
ATOM 2838 C ALA 363 82, .603 36. .616 29. .041 1. .00 36, .15 1SG2839
ATOM 2839 O ALA 363 83, .707 36. .091 28. .903 1. .00 36, .15 1SG2840
ATOM 2840 N ASN 364 82, .238 37. .690 28, .321 1. .00 36, .18 1SG2841
ATOM 2841 CA ASN 364 83, .130 38. .188 27, .316 1. .00 36, .18 1SG2842
ATOM 2842 CB ASN 364 82, .499 39. .106 26, .245 1, .00 36 .18 1SG2843
ATOM 2843 CG ASN 364 81, .817 40. .290 26, .885 1. .00 36 .18 1SG2844
ATOM 2844 ODl ASN 364 81, .294 40. .163 27, .987 1. .00 36 .18 1SG2845
ATOM 2845 ND2 ASN 364 81 .789 41. .451 26, .179 1. .00 36 .18 1SG2846
ATOM 2846 C ASN 364 84 .345 38, .795 27, .937 1. .00 36 .18 1SG2847
ATOM 2847 O ASN 364 85 .374 38, .919 27, .280 1. .00 36 .18 1SG2848
ATOM 2848 N ALA 365 84 .268 39, .213 29, .214 1. .00 36 .24 1SG2849
ATOM 2849 CA ALA 365 85 .418 39, .801 29 .839 1. .00 36 .24 1SG2850
ATOM 2850 CB ALA 365 85 .156 40, .215 31 .297 1 .00 36 .24 1SG2851
ATOM 2851 C ALA 365 86, .525 38. .789 29. .846 1. .00 36, .24 1SG2852
ATOM 2852 O ALA 365 87, .675 39. .128 29, .570 1, .00 36 , .24 1SG2853
ATOM 2853 N LYS 366 86, .214 37. .518 30, .173 1. .00 38, .10 1SG2854
ATOM 2854 CA LYS 366 87, .228 36. .501 30. .177 1, .00 38, .10 1SG2855
ATOM 2855 CB LYS 366 86, .754 35. .147 30. .732 1. .00 38, .10 1SG2856
ATOM 2856 CG LYS 366 87, .866 34 , .094 30. .715 1, .00 38, .10 1SG2857
ATOM 2857 CD LYS 366 89, .046 34. .432 31, .630 1. .00 38, .10 1SG2858
ATOM 2858 CE LYS 366 90, .256 33. .513 31, .442 1, .00 38. .10 1SG2859
ATOM 2859 NZ LYS 366 89, .932 32. .144 31, .898 1, .00 38, .10 1SG2860
ATOM 2860 C LYS 366 87, .693 36. .266 28. .773 1, .00 38, .10 1SG2861
ATOM 2861 O LYS 366 88, .886 36. .114 28. .518 1, .00 38, .10 1SG2862
ATOM 2862 N LEU 367 86, .746 36. .248 27. .819 1, .00 38, .88 1SG2863
ATOM 2863 CA LEU 367 87, .039 35. .984 26. .438 1. .00 38, .88 1SG2864
ATOM 2864 CB LEU 367 85, .788 36. .088 25. .550 1. .00 38, .88 1SG2865
ATOM 2865 CG LEU 367 84, .702 35. .045 25. .869 1. .00 38, .88 1SG2866 ATOM 2866 CD2 LEU 367 85..277 33.,620 25.843 1.00 38.88 1SG2867
ATOM 2867 CDl LEU 367 83. 485 35. 211 24. 944 1. ,00 38. 88 1SG2868
ATOM 2868 C LEU 367 87. .982 37. 039 25. 957 1. 00 38. 88 1SG2869
ATOM 2869 O LEU 367 88. .917 36. 753 25. 208 1. .00 38. 88 1SG2870
ATOM 2870 N GLN 368 87. ,745 38. .299 26. ,358 1. .00 39. 50 1SG2871
ATOM 2871 CA GLN 368 88. ,600 39. 368 25. 938 1. ,00 39. 50 1SG2872
ATOM 2872 CB GLN 368 88. 080 40. ,777 26. 242 1. ,00 39. 50 1SG2873
ATOM 2873 CG GLN 368 87. ,997 41. ,130 27. 719 1. .00 39. 50 1SG2874
ATOM 2874 CD GLN 368 87. ,807 42. ,633 27. ,743 1. ,00 39. 50 1SG2875
ATOM 2875 OEl GLN 368 88. ,658 43. ,371 27. ,249 1. .00 39. .50 1SG2876
ATOM 2876 NE2 GLN 368 86. .661 43, .099 28. .306 1. .00 39. .50 1SG2877
ATOM 2877 C GLN 368 89. .942 39. .208 26. .579 1. .00 39. .50 1SG2878
ATOM 2878 O GLN 368 90. .953 39. .608 26. .006 1, .00 39. ,50 1SG2879
ATOM 2879 N GLN 369 89, .996 38. .645 27. .804 1. .00 39, .52 1SG2880
ATOM 2880 CA GLN 369 91. .277 38. .467 28, .427 1, .00 39. .52 1SG2881
ATOM 2881 CB GLN 369 91. .195 37. .754 29. .788 1. .00 39. .52 1SG2882
ATOM 2882 CG GLN 369 90 . .460 38. .555 30. .864 1. .00 39. .52 1SG2883
ATOM 2883 CD GLN 369 90. .465 37, .724 32. .140 1, .00 39. .52 1SG2884
ATOM 2884 OEl GLN 369 91. .211 36, .753 32. .257 1, .00 39. .52 1SG2885
ATOM 2885 NE2 GLN 369 89 .608 38, .110 33. .122 1, .00 39. .52 1SG2886
ATOM 2886 C GLN 369 92. .042 37, .580 27. .503 1, .00 39, .52 1SG2887
ATOM 2887 O GLN 369 93. .208 37, .831 27. .204 1, .00 39. .52 1SG2888
ATOM 2888 N GLY 370 91. .372 36, .524 27. .002 1 .00 41. .51 1SG2889
ATOM 2889 CA GLY 370 91. .952 35, .675 26. .005 1, .00 41, .51 1SG2890
ATOM 2890 C GLY 370 92. .668 34 , .518 26. .614 1 .00 41, .51 1SG2891
ATOM 2891 O GLY 370 92. .685 34 .329 27, .831 1. .00 41, .51 1SG2892
ATOM 2892 N PHE 371 93. .262 33 .698 25. .722 1 .00 46, .19 1SG2893
ATOM 2893 CA PHE 371 94, .003 32 .537 26, .101 1, .00 46, .19 1SG2894
ATOM 2894 CB PHE 371 93 .383 31, .229 25. .577 1, .00 46, .19 1SG2895
ATOM 2895 CG PHE 371 92, .018 31 .118 26. .174 1, .00 46, .19 1SG2896
ATOM 2896 CDl PHE 371 91 .858 30 .799 27, .503 1, .00 46, .19 1SG2897
ATOM 2897 CD2 PHE 371 90, .893 31 .318 25, .404 1 .00 46, .19 1SG2898
ATOM 2898 CE1 PHE 371 90 .602 30 .695 28, .055 1, .00 46 .19 1SG2899
ATOM 2899 CE2 PHE 371 89, .634 31, .214 25, .950 1 .00 46, .19 1SG2900
ATOM 2900 CZ PHE 371 89 .486 30 .903 27, .280 1, .00 46, .19 1SG2901
ATOM 2901 C PHE 371 95, .362 32 .702 25, .490 1 .00 46, .19 1SG2902
ATOM 2902 O PHE 371 95 .510 33 .273 24, .410 1, .00 46, .19 1SG2903
ATOM 2903 N PRO 372 96, .366 32, .228 26 .173 1 .00 51, .07 1SG2904
ATOM 2904 CA PRO 372 97 .705 32 .391 25, .676 1. .00 51, .07 1SG2905
ATOM 2905 CD PRO 372 96, .326 32, .240 27, .628 1 .00 51, .07 1SG2906
ATOM 2906 CB PRO 372 98 .628 32 .102 26, .857 1, .00 51. .07 1SG2907
ATOM 2907 CG PRO 372 97 .776 32 .488 28, .080 1 .00 51. .07 1SG2908
ATOM 2908 C PRO 372 97 .992 31 .560 24, .464 1, .00 51. .07 1SG2909
ATOM 2909 O PRO 372 97 .468 30, .452 24, .357 1 .00 51, .07 1SG2910
ATOM 2910 N LEU 373 98, .833 32 .083 23 .545 1 .00 57. .30 1SG2911
ATOM 2911 CA LEU 373 99 .206 31, .364 22, .359 1 .00 57. .30 1SG2912
ATOM 2912 CB LEU 373 99, .252 32 .222 21, .083 1. .00 57. .30 1SG2913
ATOM 2913 CG LEU 373 97 .878 32 .442 20, .434 1, .00 57. .30 1SG2914
ATOM 2914 CD2 LEU 373 97, .276 31 .101 19, .979 1, .00 57. .30 1SG2915
ATOM 2915 CDl LEU 373 97 .969 33, .431 19, .268 1, .00 57. .30 1SG2916
ATOM 2916 C LEU 373 100, .573 30. .797 22 .556 1 .00 57. .30 1SG2917
ATOM 2917 O LEU 373 101 .403 31, .363 23, .263 1. .00 57. .30 1SG2918
ATOM 2918 N PRO 374 100. .797 29, .630 22, .021 1, .00 58. .88 1SG2919
ATOM 2919 CA PRO 374 102 .076 28 .991 22, .138 1, .00 58. ,88 1SG2920
ATOM 2920 CD PRO 374 100. .022 29, .109 20, .907 1, .00 58. .88 1SG2921
ATOM 2921 CB PRO 374 101 .916 27, .667 21, .400 1, .00 58. .88 1SG2922
ATOM 2922 CG PRO 374 100 .922 28 .028 20 .278 1 .00 58 .88 1SG2923 ATOM 2923 C PRO 374 103..153 29,.790 21..479 1..00 58..88 1SG2924
ATOM 2924 O PRO 374 103. .496 29, .460 20. .346 1. .00 58. .88 1SG2925
ATOM 2925 N ASN 375 103. .775 30, .776 22. .147 1. .00 58. .56 1SG2926
ATOM 2926 CA ASN 375 104. .854 31, .387 21. .430 1. .00 58, .56 1SG2927
ATOM 2927 CB ASN 375 104, .560 32 .777 20. .855 1. .00 58, .56 1SG2928
ATOM 2928 CG ASN 375 105. .453 32, .979 19. .629 1. ,00 58. .56 1SG2929
ATOM 2929 ODl ASN 375 104. .946 33, .102 18. .515 1. ,00 58. .56 1SG2930
ATOM 2930 ND2 ASN 375 106. .799 32. .998 19. .810 1. .00 58. .56 1SG2931
ATOM 2931 C ASN 375 105. .988 31. .480 22. .394 1. .00 58. .56 1SG2932
ATOM 2932 O ASN 375 105. .806 31. .686 23. .593 1. .00 58. .56 1SG2933
ATOM 2933 N PRO 376 107. .163 31. .300 21. .874 1. .00 57. .21 1SG2934
ATOM 2934 CA PRO 376 108. .333 31, .382 22. .698 1. .00 57, .21 1SG2935
ATOM 2935 CD PRO 376 107. .347 30. .302 20, .835 1. .00 57, .21 1SG2936
ATOM 2936 CB PRO 376 109, .473 30. .745 21, .898 1. .00 57, .21 1SG2937
ATOM 2937 CG PRO 376 108, .850 30 .386 20, .537 1. .00 57, .21 1SG2938
ATOM 2938 C PRO 376 108, .578 32 .782 23, .139 1. .00 57, .21 1SG2939
ATOM 2939 O PRO 376 107, .893 33 .685 22, .668 1. .00 57, .21 1SG2940
ATOM 2940 N HIS 377 109. .529 32, .964 24. .072 1. .00 54, .26 1SG2941
ATOM 2941 CA HIS 377 109. .828 34, .239 24. .649 1. .00 54, .26 1SG2942
ATOM 2942 NDl HIS 377 110. .321 35, .873 27. .587 1. .00 54, .26 1SG2943
ATOM 2943 CG HIS 377 111. .060 35, .481 26. .492 1. .00 54, .26 1SG2944
ATOM 2944 CB HIS 377 110, .875 34, .175 25. .776 1. .00 54, .26 1SG2945
ATOM 2945 NE2 HIS 377 111, .751 37, .522 27, .164 1. .00 54, .26 1SG2946
ATOM 2946 CD2 HIS 377 111, .929 36 .501 26, .248 1, .00 54, .26 1SG2947
ATOM 2947 CE1 HIS 377 110, .776 37 .099 27, .948 1, .00 54 .26 1SG2948
ATOM 2948 C HIS 377 110, .345 35 .176 23, .605 1. .00 54 .26 1SG2949
ATOM 2949 O HIS 377 110, .820 34 .769 22, .545 1. .00 54 .26 1SG2950
ATOM 2950 N LYS 378 110, .221 36 .484 23, .910 1, .00 53 .37 1SG2951
ATOM 2951 CA LYS 378 110. .656 37, .604 23. .122 1. .00 53, .37 1SG2952
ATOM 2952 CB LYS 378 112. .177 37, .895 23. .132 1. .00 53, .37 1SG2953
ATOM 2953 CG LYS 378 113. .121 36, .770 22. .697 1. .00 53, .37 1SG2954
ATOM 2954 CD LYS 378 113. .254 35, .632 23. .710 1. .00 53, .37 1SG2955
ATOM 2955 CE LYS 378 114. .387 34 .653 23. .391 1. .00 53, .37 1SG2956
ATOM 2956 NZ LYS 378 115. .684 35 .235 23 , .804 1. .00 53. .37 1SG2957
ATOM 2957 C LYS 378 110. .166 37 .545 21. .712 1. .00 53 .37 1SG2958
ATOM 2958 O LYS 378 110. .925 37 .792 20. .776 1. .00 53, .37 1SG2959
ATOM 2959 N PHE 379 108, .867 37 .245 21, .516 1. .00 50, .37 1SG2960
ATOM 2960 CA PHE 379 108, .351 37 .261 20. .178 1. .00 50, .37 1SG2961
ATOM 2961 CB PHE 379 107, .824 35 .905 19. .673 1, .00 50, .37 1SG2962
ATOM 2962 CG PHE 379 106. .439 35, .792 20. .215 1. .00 50. .37 1SG2963
ATOM 2963 CDl PHE 379 106. .215 35, .548 21. .550 1. ,00 50. .37 1SG2964
ATOM 2964 CD2 PHE 379 105. .358 35, .924 19. .371 1. .00 50. .37 1SG2965
ATOM 2965 CE1 PHE 379 104. .931 35, .458 22. .034 1. .00 50. .37 1SG2966
ATOM 2966 CE2 PHE 379 104. .077 35, .837 19. .851 1. .00 50. .37 1SG2967
ATOM 2967 CZ PHE 379 103. .860 35, .607 21. .185 1. .00 50. .37 1SG2968
ATOM 2968 C PHE 379 107. .111 38, .100 20, .270 1. .00 50. .37 1SG2969
ATOM 2969 O PHE 379 106. .540 38 .267 21, .349 1. .00 50. .37 1SG2970
ATOM 2970 N LEU 380 106. .669 38, .663 19, .129 1. .00 46. .28 1SG2971
ATOM 2971 CA LEU 380 105, .437 39 .398 19, .090 1. .00 46. .28 1SG2972
ATOM 2972 CB LEU 380 105, .623 40 .926 19, .100 1. .00 46. .28 1SG2973
ATOM 2973 CG LEU 380 106. .274 41 .470 20. .386 1. .00 46. .28 1SG2974
ATOM 2974 CD2 LEU 380 106. ,162 43, .001 20. .460 1. .00 46. .28 1SG2975
ATOM 2975 CDl LEU 380 107. .721 40, .971 20. .541 1. .00 46. ,28 1SG2976
ATOM 2976 C LEU 380 104. .793 39, .043 17. .784 1. ,00 46. ,28 1SG2977
ATOM 2977 O LEU 380 105. ,488 38. .854 16. .787 1. ,00 46. ,28 1SG2978
ATOM 2978 N PHE 381 103. ,447 38. .933 17. .748 1. .00 42. .97 1SG2979
ATOM 2979 CA PHE 381 102. .784 38. .587 16. .515 1. ,00 42. .97 1SG2980 H H H ^ H H μ- i-3 H H H H H 3 H H H β H H H ι-_ H H β H H H H H H H ^ H H H _ H ι-. H ^. H H H H >-- H H H H μ_ H H ι-. ι-3 o d d o d o P P O P O P P d O d d P P O P d P P d d d O d d o d d P P d d d d d P P d d O d P p o P d d d o d Q d
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-o cn ιn ιf* uι tθ H o ιo cD ^ cn ιn 4* u tθ H θ VD θo ^ en ιn 4* UJ tθ H o vo oo -j cn ui 4* UJ tθ H θ iD θD ^ en ιn 4* u» tθ H θ vo oo -j en ui ιt* uι tθ H
ATOM 3037 CB VAL 388 86..576 30.354 10,.070 1.00 42.24 1SG3038
ATOM 3038 CGI VAL 388 85. .651 30 .693 8 .890 1 .00 42 .24 1SG3039
ATOM 3039 CG2 VAL 388 86. .137 29 .142 10, .909 1 .00 42 .24 1SG3040
ATOM 3040 C VAL 388 87. .880 29 .084 8 .447 1 .00 42 .24 1SG3041
ATOM 3041 O VAL 388 87. .710 29 .426 7 .278 1 .00 42 .24 1SG3042
ATOM 3042 N LEU 389 88. .052 27 .800 8 .802 1 .00 42 .63 1SG3043
ATOM 3043 CA LEU 389 87. .968 26 .764 7 .822 1 .00 42 .63 1SG3044
ATOM 3044 CB LEU 389 89. .319 26 .225 7 .331 1 .00 42 .63 1SG3045
ATOM 3045 CG LEU 389 90, .088 27 .237 6 .461 1 .00 42 .63 1SG3046
ATOM 3046 CD2 LEU 389 89, .174 27, .848 5 .386 1 .00 42 .63 1SG3047
ATOM 3047 CDl LEU 389 91, .363 26, .612 5 .871 1, .00 42 .63 1SG3048
ATOM 3048 C LEU 389 87, .155 25, .658 8, .399 1, .00 42 .63 1SG3049
ATOM 3049 O LEU 389 86, .594 25. .785 9, .486 1, .00 42 .63 1SG3050
ATOM 3050 N GLU 390 87, .040 24. .541 7, .660 1. .00 43 .41 1SG3051
ATOM 3051 CA GLU 390 86, .186 23, .499 8, .136 1, .00 43 .41 1SG3052
ATOM 3052 CB GLU 390 85, .799 22. .481 7, .047 1, .00 43 .41 1SG3053
ATOM 3053 CG GLU 390 84. .735 21. .473 7, .488 1, .00 43 .41 1SG3054
ATOM 3054 CD GLU 390 83. .382 22. .172 7, .469 1, .00 43 .41 1SG3055
ATOM 3055 OEl GLU 390 82. .730 22. .162 6 , .391 1, .00 43 .41 1SG3056
ATOM 3056 OE2 GLU 390 82. .984 22. .729 8, .527 1, .00 43 .41 1SG3057
ATOM 3057 C GLU 390 86. .863 22. .758 9, .242 1, .00 43 .41 1SG3058
ATOM 3058 O GLU 390 87. .868 22, .077 9, .039 1, .00 43 .41 1SG3059
ATOM 3059 N GLY 391 86. .302 22 .887 10 .461 1 .00 46 .01 1SG3060
ATOM 3060 CA GLY 391 86. .752 22 .139 11 .599 1 .00 46 .01 1SG3061
ATOM 3061 C GLY 391 87. .927 22 .773 12 .275 1 .00 46 .01 1SG3062
ATOM 3062 O GLY 391 88. .426 22, .226 13 .260 1 .00 46 .01 1SG3063
ATOM 3063 N PHE 392 88. .421 23 .925 11, .786 1 .00 50 .43 1SG3064
ATOM 3064 CA PHE 392 89. .536 24, .492 12, .488 1, .00 50 .43 1SG3065
ATOM 3065 CB PHE 392 90. .860 23, .807 12, .151 1, .00 50 .43 1SG3066
ATOM 3066 CG PHE 392 91. .223 24, .128 10, .740 1, .00 50 .43 1SG3067
ATOM 3067 CDl PHE 392 90. .488 23, .635 9, .702 1, .00 50 .43 1SG3068
ATOM 3068 CD2 PHE 392 92, .265 24 , .961 10, .429 1 .00 50 .43 1SG3069
ATOM 3069 CE1 PHE 392 90, .813 23 , .925 8. .397 1, .00 50 .43 1SG3070
ATOM 3070 CE2 PHE 392 92, .600 25. .254 9, .127 1, .00 50 .43 1SG3071
ATOM 3071 CZ PHE 392 91. .873 24. .730 8. .093 1, .00 50 .43 1SG3072
ATOM 3072 C PHE 392 89, .666 25. .926 12. .103 1, .00 50 .43 1SG3073
ATOM 3073 O PHE 392 89. .087 26. .373 11. .114 1, .00 50 .43 1SG3074
ATOM 3074 N LEU 393 90. .446 26. .684 12. .899 1, .00 52 .01 1SG3075
ATOM 3075 CA LEU 393 90. .655 28. .078 12. .653 1, .00 52, .01 1SG3076
ATOM 3076 CB LEU 393 90. .474 28. .939 13. .918 1, .00 52, .01 1SG3077
ATOM 3077 CG LEU 393 90. .678 30. .445 13. ,688 1. .00 52, .01 1SG3078
ATOM 3078 CD2 LEU 393 90. .688 31. ,222 15. ,019 1. .00 52, .01 1SG3079
ATOM 3079 CDl LEU 393 89. .640 30. .979 12. .689 1. .00 52, .01 1SG3080
ATOM 3080 C LEU 393 92. .060 28. ,247 12. .176 1. .00 52. .01 1SG3081
ATOM 3081 O LEU 393 92. .995 27. .631 12. .686 1. .00 52. .01 1SG3082
ATOM 3082 N LEU 394 92. .240 29. .100 11. .157 1. .00 52. .96 1SG3083
ATOM 3083 CA LEU 394 93. .552 29. .298 10. .630 1. .00 52. .96 1SG3084
ATOM 3084 CB LEU 394 93. .529 29. .163 9. .098 1. .00 52. .96 1SG3085
ATOM 3085 CG LEU 394 94. .883 29. .387 8. .436 1. .00 52. .96 1SG3086
ATOM 3086 CD2 LEU 394 95. .992 28. .795 9. .312 1. .00 52, .96 1SG3087
ATOM 3087 CDl LEU 394 95. .117 30. .875 8. .184 1. .00 52, .96 1SG3088
ATOM 3088 C LEU 394 94. .048 30. .645 11. ,075 1. .00 52 , .96 1SG3089
ATOM 3089 O LEU 394 93. .424 31. ,671 10. ,805 1. .00 52. .96 1SG3090
ATOM 3090 N ILE 395 95. .189 30. ,666 11. ,805 1. ,00 49. .02 1SG3091
ATOM 3091 CA ILE 395 95. ,742 31. ,903 12. .288 1. ,00 49. .02 1SG3092
ATOM 3092 CB ILE 395 95. ,949 31. ,930 13. 777 1. ,00 49. .02 1SG3093
ATOM 3093 CG2 ILE 395 96. ,687 33. 234 14. 124 1. ,00 49. ,02 1SG3094 ATOM 3094 CGI ILE 395 94..609 31..778 14..517 1..00 49..02 1SG3095
ATOM 3095 CDl ILE 395 93, .632 32. .922 14. .250 1. .00 49. .02 1SG3096
ATOM 3096 C ILE 395 97, .084 32. .089 11. .657 1. .00 49. .02 1SG3097
ATOM 3097 O ILE 395 97. .990 31. .277 11, .838 1. .00 49. .02 1SG3098
ATOM 3098 N SER 396 97. .252 33. .187 10, .896 1. .00 43. .96 1SG3099
ATOM 3099 CA SER 396 98, .503 33. .409 10, .233 1. .00 43. .96 1SG3100
ATOM 3100 CB SER 396 98, .345 33. .477 8, .706 1. .00 43. .96 1SG3101
ATOM 3101 OG SER 396 99, .606 33. .662 8, .087 1. .00 43. .96 1SG3102
ATOM 3102 C SER 396 99, .031 34. .726 10, .712 1. .00 43. .96 1SG3103
ATOM 3103 O SER 396 98. .260 35. .653 10, .957 1. .00 43. .96 1SG3104
ATOM 3104 N THR 397 100, .366 34. .838 10, .894 1. .00 41. .17 1SG3105
ATOM 3105 CA THR 397 100 .882 36. .085 11 .384 1, .00 41. .17 1SG3106
ATOM 3106 CB THR 397 100 .754 36. .209 12 .874 1, .00 41. .17 1SG3107
ATOM 3107 OGl THR 397 101 .104 37, .519 13 .296 1, .00 41, .17 1SG3108
ATOM 3108 CG2 THR 397 101 .677 35, .170 13 .533 1, .00 41, .17 1SG3109
ATOM 3109 C THR 397 102 .340 36, .222 11 .062 1, .00 41, .17 1SG3110
ATOM 3110 O THR 397 102 .995 35, .278 10 .624 1, .00 41 .17 1SG3111
ATOM 3111 N ASP 398 102 .873 37, .446 11 .276 1, .00 38, .24 1SG3112
ATOM 3112 CA ASP 398 104 .270 37, .737 11 .110 1. .00 38 .24 1SG3113
ATOM 3113 CB ASP 398 104 .560 39, .066 10 .391 1, .00 38 .24 1SG3114
ATOM 3114 CG ASP 398 104 .220 38, .900 8 .917 1 .00 38 .24 1SG3115
ATOM 3115 ODl ASP 398 104 .543 37, .820 8 .353 1, .00 38 .24 1SG3116
ATOM 3116 OD2 ASP 398 103 .627 39, .848 8 .337 1 .00 38 .24 1SG3117
ATOM 3117 C ASP 398 104 .818 37, .851 12 .498 1, .00 38 .24 1SG3118
ATOM 3118 O ASP 398 104 .093 38, .203 13 .426 1, .00 38 .24 1SG3119
ATOM 3119 N LEU 399 106 .113 37, .534 12 .685 1 .00 37 .66 1SG3120
ATOM 3120 CA LEU 399 106 .668 37. .544 14 .009 1, .00 37 .66 1SG3121
ATOM 3121 CB LEU 399 107 .212 36. .151 14 .399 1, .00 37 .66 1SG3122
ATOM 3122 CG LEU 399 107 .836 36. .021 15 .803 1, .00 37 .66 1SG3123
ATOM 3123 CD2 LEU 399 106 .850 36. .471 16 .888 1, .00 37, .66 1SG3124
ATOM 3124 CDl LEU 399 109 .202 36. .720 15 .901 1, .00 37 .66 1SG3125
ATOM 3125 C LEU 399 107 .783 38. .538 14 .069 1, .00 37 .66 1SG3126
ATOM 3126 O LEU 399 108 .486 38. .773 13, .089 1, .00 37. .66 1SG3127
ATOM 3127 N LYS 400 107 .950 39, .171 15 .247 1, .00 37. .07 1SG3128
ATOM 3128 CA LYS 400 109 .028 40, .092 15 .455 1, .00 37. .07 1SG3129
ATOM 3129 CB LYS 400 108, .569 41, .496 15 .881 1, .00 37. .07 1SG3130
ATOM 3130 CG LYS 400 109 .720 42 , .484 16 .077 1, .00 37. .07 1SG3131
ATOM 3131 CD LYS 400 110, .440 42 , .852 14, .777 1, .00 37. .07 1SG3132
ATOM 3132 CE LYS 400 111, .569 43. .867 14, .965 1. .00 37, .07 1SG3133
ATOM 3133 NZ LYS 400 112. .718 43, .226 15 .642 1, .00 37, .07 1SG3134
ATOM 3134 C LYS 400 109. .815 39, .519 16, .585 1, .00 37, .07 1SG3135
ATOM 3135 O LYS 400 109. .245 39. .029 17, .557 1. .00 37. .07 1SG3136
ATOM 3136 N TYR 401 111. .155 39. .549 16, .480 1. .00 35. .17 1SG3137
ATOM 3137 CA TYR 401 Ill, .963 38. .973 17, .514 1. .00 35. .17 1SG3138
ATOM 3138 CB TYR 401 113 , .025 38. .017 16, .940 1. .00 35. .17 1SG3139
ATOM 3139 CG TYR 401 113. .849 37. .430 18. .034 1. .00 35. .17 1SG3140
ATOM 3140 CDl TYR 401 114 , .848 38. .159 18. .637 1. .00 35. .17 1SG3141
ATOM 3141 CD2 TYR 401 113. .635 36. .132 18, .436 1. .00 35. .17 1SG3142
ATOM 3142 CE1 TYR 401 115. .610 37. .602 19, .638 1. .00 35. .17 1SG3143
ATOM 3143 CE2 TYR 401 114. .393 35. .571 19. .436 1. .00 35. .17 1SG3144
ATOM 3144 CZ TYR 401 115. .382 36. .309 20. .039 1. ,00 35. ,17 1SG3145
ATOM 3145 OH TYR 401 116. .166 35. ,741 21. .065 1. ,00 35. ,17 1SG3146
ATOM 3146 C TYR 401 112. .668 40. ,111 18. .169 1. ,00 35. ,17 1SG3147
ATOM 3147 O TYR 401 113. .342 40. ,901 17. .510 1. ,00 35. ,17 1SG3148
ATOM 3148 N GLU 402 112. .515 40. ,231 19. .501 1. .00 31. ,96 1SG3149
ATOM 3149 CA GLU 402 113. .138 41. ,315 20. .196 1. ,00 31. .96 1SG3150
ATOM 3150 CB GLU 402 112. .805 41. .352 21. .698 1. .00 31. .96 1SG3151
Figure imgf000521_0001
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Ul l Ul UJ UJ l J H H H H H H H
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4* 4* ι^ ι^ ιt* ι^ UJ UJ UI UJ UI UJ UJ UI UJ UI tO tO tO tO tO tO I tO tO tO H H H H H H H H H H ui ui ui ui ui in ui ιn 4* UJ M H θ vD _3 -j σι 4* ι*ι t H θ vo cD ^j σι ui ιi* UJ tθ H θ vD θo -j σι uι 4* uι t H θ vo co ~ σι uι 4* uι to oo on i 4* ui to
H H >-3 '-3 >-3 H 4 H H H H '-_ β H _ H H 3 H H H ^ H H H H _ _ H H H H H
P d P d p P O P d d P O d d P P d d d P P P P P P O P P P d d P d d d d d p p p p p p d d d P p p p p p p p d d d
2 3 2 2 3 3 2 2 3 2 2 3 3 2 2 2 3 2 2 2 2 2 2 2 2 3 3 2 2 3 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2
a P Ω Ω
N to to te ta to tl P W W W & » > Ω Ω Ω Ω Ω
Figure imgf000522_0001
H H H H H H H H H H H H H H H H H H H H H H H
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H O O O O O O O O O O O O O O O O O O O oo o o o oo o oo o uJ H tθ H θ θ θ- iD Co σi 4* uι σι _ι -j -i ιo oo oo ^] σ! uι uJ 4* H σi H - σ vo uι σi -i 4* to m uj σι oo oo H H io oi oo oi co μ u μ μ iD * *
Figure imgf000522_0002
_- H Cn ιt* -j v] θo tn cn uι o oo vD H Ui co H UJ to oo H in H θ o to -j vD UJ to ^ι ^ι uι uι o cn 4* tθ H H in l» 4* UI UJ W _J VD 01 lO ^ Ul ^l J H UJ U1 4* 4* 01 C0 4* tO UI -J Cn _. tO UI rf* UJ (n VD VO UJ ^I 01 Ul tO CD UJ O
σ o o o oo o o o oo o o σ o oo σ o oo o o o o σo o o o o o o o o oo o o o oo o o o o o o o o oooo ooooo ooo o o ooo oo ooo oooo ooo oo o o o o o o o o oo o o o o o o o o o
to towto toto tototo to to tototo toto toto to toto totow toto tototomto to toto totowtototototomtotototototomtototototo -i to Ώ ΩΏΩ ΩΏ Ω Ω Ω Ω ΏΩ ΩΩ ΩΩ Ω ΩΩ ΩΩ ΏΩΏ ΏΩ ΏΩΩ ΩΩ ΏΩ Ω ΩΩΩΩΩ Ω Ω ΏΩΩΩ ΩΩΏΩ ΩΩ ΩΩ ΩΏΩΩ
-j -o -j -j ^i ^i -o en cn σi σi σi σ σi oi σ σi ui ui ui ui ui ui
On i π __ 1.1 Kl l-i i— » in m _1 m in J_ l_ Kl l-i r-i in m ^ι on In __
ATOM 102 CB ALA 13 108.646 31.916 8,.511 1..00 24,.49 ISG 103
ATOM 103 C ALA 13 111. .021 32 .226 7, .952 1. .00 24, .49 ISG 104
ATOM 104 O ALA 13 Ill .758 32 .651 8 .840 1. .00 24, .49 ISG 105
ATOM 105 N LEU 14 111 .396 31 .236 7 .122 1. .00 22. .72 ISG 106
ATOM 106 CA LEU 14 112 .671 30 .587 7, .247 1. .00 22. .72 ISG 107
ATOM 107 CB LEU 14 112 .870 29 .473 6 .202 1, .00 22 .72 ISG 108
ATOM 108 CG LEU 14 111 .922 28 .273 6 .377 1. .00 22. .72 ISG 109
ATOM 109 CD2 LEU 14 112 .002 27 .702 7 .802 1. .00 22. .72 ISG 110
ATOM 110 CDl LEU 14 112 .182 27 .204 5, .302 1, .00 22 .72 ISG 111
ATOM 111 C LEU 14 113 .755 31 .590 7 .008 1, .00 22 .72 ISG 112
ATOM 112 O LEU 14 114 .752 31 .622 7, .729 1. .00 22. .72 ISG 113
ATOM 113 N ASP 15 113, .574 32 .458 5 .995 1. .00 21 .16 ISG 114
ATOM 114 CA ASP 15 114 .594 33 .405 5 .651 1, .00 21, .16 ISG 115
ATOM 115 CB ASP 15 114 .196 34 .330 4 .487 1. .00 21, .16 ISG 116
ATOM 116 CG ASP 15 114, .262 33, .533 3 .194 1. .00 21, .16 ISG 117
ATOM 117 ODl ASP 15 114 .865 32 .427 3 .211 1, .00 21 .16 ISG 118
ATOM 118 OD2 ASP 15 113 .719 34 .025 2 .170 1. .00 21 .16 ISG 119
ATOM 119 C ASP 15 114. .852 34 , .283 6, .829 1. .00 21. .16 ISG 120
ATOM 120 O ASP 15 115 .999 34 .614 7 .125 1. .00 21 .16 ISG 121
ATOM 121 N TYR 16 113 .782 34, .683 7 .537 1. .00 20 .80 ISG 122
ATOM 122 CA TYR 16 113, .925 35, .567 8, .655 1. .00 20, .80 ISG 123
ATOM 123 CB TYR 16 112 .569 35 .972 9 .256 1. .00 20 .80 ISG 124
ATOM 124 CG TYR 16 112, .805 37, .044 10 .264 1, .00 20 .80 ISG 125
ATOM 125 CDl TYR 16 113, .033 38, .337 9, .852 1. .00 20, .80 ISG 126
ATOM 126 CD2 TYR 16 112 .786 36, .769 11 .612 1. .00 20 .80 ISG 127
ATOM 127 CE1 TYR 16 113 .248 39, .340 10, .765 1. .00 20 .80 ISG 128
ATOM 128 CE2 TYR 16 113, .000 37. .769 12, .532 1. .00 20, .80 ISG 129
ATOM 129 CZ TYR 16 113 .233 39. .056 12 .109 1. .00 20 .80 ISG 130
ATOM 130 OH TYR 16 113 .452 40. .084 13, .051 1. .00 20 .80 ISG 131
ATOM 131 C TYR 16 114, .713 34. .865 9, .713 1. .00 20, .80 ISG 132
ATOM 132 O TYR 16 115 .604 35 .450 10 .328 1, .00 20 .80 ISG 133
ATOM 133 N GLY 17 114, .409 33. .574 9, .942 1. .00 20 .56 ISG 134
ATOM 134 CA GLY 17 115, .082 32. .838 10, .970 1. .00 20, .56 ISG 135
ATOM 135 C GLY 17 116 .539 32. .792 10, .644 1. .00 20 .56 ISG 136
ATOM 136 O GLY 17 117, .388 32, .918 11, .525 1. .00 20, .56 ISG 137
ATOM 137 N VAL 18 116, .859 32 , .606 9, .352 1. .00 20, .58 ISG 138
ATOM 138 CA VAL 18 118 .216 32 .470 8 .905 1. .00 20 .58 ISG 139
ATOM 139 CB VAL 18 118, .302 32, .265 7, .425 1. .00 20, .58 ISG 140
ATOM 140 CGI VAL 18 119, .784 32, .140 7, .036 1. .00 20, .58 ISG 141
ATOM 141 CG2 VAL 18 117 .410 31 .083 7, .036 1. .00 20 .58 ISG 142
ATOM 142 C VAL 18 118, .960 33, .749 9, .169 1. .00 20, .58 ISG 143
ATOM 143 O VAL 18 120, .093 33. .719 9. .644 1. .00 20, .58 ISG 144
ATOM 144 N GLN 19 118, .335 34. .896 8, .858 1. .00 22, .50 ISG 145
ATOM 145 CA GLN 19 119, .014 36. .148 8, .995 1. .00 22, .50 ISG 146
ATOM 146 CB GLN 19 118. .190 37. .347 8. .494 1. .00 22. .50 ISG 147
ATOM 147 CG GLN 19 118. .946 38, .673 8. .587 1. .00 22. .50 ISG 148
ATOM 148 CD GLN 19 118. .043 39, .786 8. .070 1. .00 22. .50 ISG 149
ATOM 149 OEl GLN 19 116. .819 39. .695 8. .144 1. ,00 22. .50 ISG 150
ATOM 150 NE2 GLN 19 118, .663 40, .870 7, .533 1. .00 22, .50 ISG 151
ATOM 151 C GLN 19 119. .323 36. .385 10. .434 1. .00 22. .50 ISG 152
ATOM 152 O GLN 19 120. .414 36. .837 10. .774 1. .00 22. ,50 ISG 153
ATOM 153 N ALA 20 118, .364 36. .083 11. .324 1. .00 24. .21 ISG 154
ATOM 154 CA ALA 20 118, .596 36. .301 12. .720 1. .00 24. ,21 ISG 155
ATOM 155 CB ALA 20 117. .373 35. ,959 13. .590 1. .00 24. ,21 ISG 156
ATOM 156 C ALA 20 119, .716 35. .412 13. .154 1. ,00 24. .21 ISG 157
ATOM 157 0 ALA 20 120. .597 35. ,828 13. .906 1. ,00 24. .21 ISG 158
ATOM 158 N GLY 21 119. ,705 34. ,153 12. .678 1. 00 28. .24 ISG 159 ATOM 159 CA GLY 21 120..692 33..194 13..082 1.00 28.,24 ISG 160
ATOM 160 C GLY 21 122. ,058 33. .600 12. ,626 1. 00 28. ,24 ISG 161
ATOM 161 O GLY 21 123. ,012 33. .565 13. ,401 1. 00 28. 24 ISG 162
ATOM 162 N MET 22 122. .188 34, .026 11. .358 1. .00 32. ,41 ISG 163
ATOM 163 CA MET 22 123. .484 34, .336 10. .833 1. .00 32. ,41 ISG 164
ATOM 164 CB MET 22 123. .419 34, .733 9. .342 1. 00 32. .41 ISG 165
ATOM 165 CG MET 22 122. .755 36. .078 9. .034 1. 00 32. .41 ISG 166
ATOM 166 SD MET 22 123. .791 37. .552 9. .293 1. .00 32. .41 ISG 167
ATOM 167 CE MET 22 122. .468 38. .735 8. .906 1. ,00 32. .41 ISG 168
ATOM 168 C MET 22 124. .050 35. .458 11. .641 1. ,00 32. .41 ISG 169
ATOM 169 O MET 22 125. .214 35. .426 12. .037 1. 00 32. .41 ISG 170
ATOM 170 N LYS 23 123. .215 36. .458 11. .962 1. .00 32. .78 ISG 171
ATOM 171 CA LYS 23 123. .706 37. .592 12. .683 1. .00 32. .78 ISG 172
ATOM 172 CB LYS 23 122. .598 38. .609 13. .005 1. .00 32. .78 ISG 173
ATOM 173 CG LYS 23 123. .105 39, .829 13. .774 1. .00 32. .78 ISG 174
ATOM 174 CD LYS 23 122. .065 40 .940 13. .890 1. .00 32. .78 ISG 175
ATOM 175 CE LYS 23 122 , .535 42, .129 14. .725 1. .00 32. .78 ISG 176
ATOM 176 NZ LYS 23 121. .464 43, .147 14 , .786 1. .00 32. .78 ISG 177
ATOM 177 C LYS 23 124. .251 37, .103 13. .983 1. .00 32. .78 ISG 178
ATOM 178 O LYS 23 125. .330 37 .510 14, .406 1. .00 32. .78 ISG 179
ATOM 179 N MET 24 123, .520 36 .186 14, .641 1. .00 32. .67 ISG 180
ATOM 180 CA MET 24 123, .927 35 .650 15, .906 1. .00 32, .67 ISG 181
ATOM 181 CB MET 24 122. .885 34, .689 16, .505 1. .00 32, .67 ISG 182
ATOM 182 CG MET 24 121. .546 35 .367 16 .807 1. .00 32 .67 ISG 183
ATOM 183 SD MET 24 121, .618 36 .656 18 .087 1. .00 32 .67 ISG 184
ATOM 184 CE MET 24 121, .716 35 .498 19, .482 1, .00 32, .67 ISG 185
ATOM 185 C MET 24 125, .193 34 .873 15, .704 1. .00 32, .67 ISG 186
ATOM 186 O MET 24 126, .057 34 .834 16, .579 1. .00 32 .67 ISG 187
ATOM 187 N ILE 25 125, .309 34 .204 14 .543 1. .00 30 .35 ISG 188
ATOM 188 CA ILE 25 126, .429 33 .376 14 .200 1, .00 30, .35 ISG 189
ATOM 189 CB ILE 25 126, .226 32 .653 12, .899 1. .00 30, .35 ISG 190
ATOM 190 CG2 ILE 25 127, .532 31 .922 12, .552 1. .00 30, .35 ISG 191
ATOM 191 CGI ILE 25 125, .006 31 .722 12 .989 1. .00 30 .35 ISG 192
ATOM 192 CDl ILE 25 124, .560 31 .174 11 .634 1. .00 30 .35 ISG 193
ATOM 193 C ILE 25 127, .676 34 .199 14, .066 1. .00 30, .35 ISG 194
ATOM 194 O ILE 25 128, .746 33 .784 14, .507 1. .00 30, .35 ISG 195
ATOM 195 N GLU 26 127, .569 35 .398 13 .465 1. .00 29 .04 ISG 196
ATOM 196 CA GLU 26 128, .723 36 .200 13 .171 1. .00 29 .04 ISG 197
ATOM 197 CB GLU 26 128, .356 37 .555 12. .545 1. .00 29 .04 ISG 198
ATOM 198 CG GLU 26 129. .569 38 .431 12, .221 1. .00 29, .04 ISG 199
ATOM 199 CD GLU 26 129, .060 39 .731 11 .617 1. .00 29 .04 ISG 200
ATOM 200 OEl GLU 26 127, .814 39 .909 11 .567 1. .00 29 .04 ISG 201
ATOM 201 OE2 GLU 26 129, .907 40 .565 11, .200 1. .00 29, .04 ISG 202
ATOM 202 C GLU 26 129, .490 36 .493 14, .423 1. .00 29, .04 ISG 203
ATOM 203 O GLU 26 130, .719 36 .421 14 .431 1. .00 29 .04 ISG 204
ATOM 204 N GLN 27 128, .792 36 .813 15 .525 1. .00 31, .83 ISG 205
ATOM 205 CA GLN 27 129. .478 37 .191 16 .726 1, .00 31, .83 ISG 206
ATOM 206 CB GLN 27 128. .509 37. .550 17, .867 1, .00 31, .83 ISG 207
ATOM 207 CG GLN 27 127. .664 38 .791 17 .572 1, .00 31 .83 ISG 208
ATOM 208 CD GLN 27 126, .748 39 .034 18 .762 1, .00 31, .83 ISG 209
ATOM 209 OEl GLN 27 126, .668 38 .219 19 .679 1, .00 31, .83 ISG 210
ATOM 210 NE2 GLN 27 126 , .029 40, .188 18, .746 1, .00 31, .83 ISG 211
ATOM 211 C GLN 27 130, .326 36 .054 17 .200 1, .00 31, .83 ISG 212
ATOM 212 0 GLN 27 131, .471 36 .255 17 .601 1, .00 31, .83 ISG 213
ATOM 213 N MET 28 129, .790 34 .824 17 .153 1. .00 36, .84 ISG 214
ATOM 214 CA MET 28 130. .515 33, .684 17, .633 1. .00 36. .84 ISG 215
ATOM 215 CB MET 28 129, .681 32 .392 17 .623 1. .00 36, .84 ISG 216 ATOM 216 CG MET 28 130..328 31..259 18.,422 1..00 36..84 ISG 217
ATOM 217 SD MET 28 130. .309 31. .501 20. .224 1. ,00 36. .84 ISG 218
ATOM 218 CE MET 28 128. .519 31. .255 20. .405 1. ,00 36. .84 ISG 219
ATOM 219 C MET 28 131. .722 33. .465 16. .772 1. .00 36. .84 ISG 220
ATOM 220 O MET 28 132. .785 33. .098 17. .271 1. .00 36. .84 ISG 221
ATOM 221 N LEU 29 131. .591 33. .680 15. .449 1. .00 42. .92 ISG 222
ATOM 222 CA LEU 29 132. .687 33. .459 14. .545 1. .00 42. .92 ISG 223
ATOM 223 CB LEU 29 132. .315 33. .627 13. .062 1. .00 42. .92 ISG 224
ATOM 224 CG LEU 29 131, .625 32. .392 12. .461 1. .00 42. .92 ISG 225
ATOM 225 CD2 LEU 29 130, .392 31, .972 13. .269 1. .00 42. .92 ISG 226
ATOM 226 CDl LEU 29 132, .630 31, .242 12. .301 1. .00 42. .92 ISG 227
ATOM 227 C LEU 29 133, .822 34, .388 14, .834 1. .00 42, .92 ISG 228
ATOM 228 O LEU 29 134. .985 33. .993 14. .765 1. .00 42. .92 ISG 229
ATOM 229 N LYS 30 133. .524 35. .653 15. .172 1. .00 47. .10 ISG 230
ATOM 230 CA LYS 30 134. .570 36. .614 15. .389 1. .00 47. .10 ISG 231
ATOM 231 CB LYS 30 134. .059 38. .049 15. .615 1. .00 47. .10 ISG 232
ATOM 232 CG LYS 30 133, .361 38. .281 16, .954 1. .00 47. .10 ISG 233
ATOM 233 CD LYS 30 133, .156 39. .764 17. .273 1. .00 47. .10 ISG 234
ATOM 234 CE LYS 30 134, .449 40. .583 17. .243 1. .00 47, .10 ISG 235
ATOM 235 NZ LYS 30 135, .365 40. .129 18, .313 1. .00 47, .10 ISG 236
ATOM 236 C LYS 30 135, .401 36. .205 16, .571 1, .00 47, .10 ISG 237
ATOM 237 O LYS 30 136 .579 36. .545 16, .655 1, .00 47, .10 ISG 238
ATOM 238 N GLU 31 134, .788 35, .479 17, .523 1. .00 49, .21 ISG 239
ATOM 239 CA GLU 31 135 .376 35, .050 18, .764 1, .00 49 .21 ISG 240
ATOM 240 CB GLU 31 134, .344 34, .428 19, .721 1 .00 49 .21 ISG 241
ATOM 241 CG GLU 31 133 .306 35, .431 20 .232 1 .00 49 .21 ISG 242
ATOM 242 CD GLU 31 133 .982 36 .345 21 .246 1 .00 49 .21 ISG 243
ATOM 243 OEl GLU 31 135, .163 36, .075 21, .592 1, .00 49, .21 ISG 244
ATOM 244 OE2 GLU 31 133, .325 37. .324 21, .690 1, .00 49, .21 ISG 245
ATOM 245 C GLU 31 136, .477 34, .043 18, .572 1, .00 49. .21 ISG 246
ATOM 246 O GLU 31 137, .317 33, .893 19, .454 1, .00 49. .21 ISG 247
ATOM 247 N LYS 32 136, .496 33 , .293 17, .456 1, .00 50, .25 ISG 248
ATOM 248 CA LYS 32 137, .444 32, .223 17, .291 1, .00 50, .25 ISG 249
ATOM 249 CB LYS 32 137 .317 31, .506 15, .934 1, .00 50, .25 ISG 250
ATOM 250 CG LYS 32 137 .364 32, .452 14 .736 1, .00 50, .25 ISG 251
ATOM 251 CD LYS 32 137 .519 31, .743 13, .392 1, .00 50, .25 ISG 252
ATOM 252 CE LYS 32 138 .913 31, .156 13 .170 1, .00 50. .25 ISG 253
ATOM 253 NZ LYS 32 139 .901 32 .243 12 .982 1, .00 50. .25 ISG 254
ATOM 254 C LYS 32 138 .855 32 .681 17 .486 1, .00 50. .25 ISG 255
ATOM 255 O LYS 32 139 .255 33 .773 17, .084 1, .00 50, .25 ISG 256
ATOM 256 N LYS 33 139 .654 31 .823 18 .154 1, .00 49, .87 ISG 257
ATOM 257 CA LYS 33 141 .021 32 .157 18 .413 1 .00 49, .87 ISG 258
ATOM 258 CB LYS 33 141, .427 31. .984 19, .888 1. .00 49. .87 ISG 259
ATOM 259 CG LYS 33 140, .812 33, .017 20. .837 1. .00 49. .87 ISG 260
ATOM 260 CD LYS 33 141, .260 34 , .455 20, .561 1, .00 49. .87 ISG 261
ATOM 261 CE LYS 33 140, .660 35, .483 21, .524 1. .00 49. .87 ISG 262
ATOM 262 NZ LYS 33 141, .217 36, .825 21, .243 1. .00 49. .87 ISG 263
ATOM 263 C LYS 33 141, .885 31, .245 17, .607 1. .00 49, .87 ISG 264
ATOM 264 O LYS 33 141, .727 30, .024 17, .635 1. .00 49, .87 ISG 265
ATOM 265 N LEU 34 142, .827 31, .830 16, .844 1, .00 50, .17 ISG 266
ATOM 266 CA LEU 34 143, .729 31, .024 16, .085 1, .00 50, .17 ISG 267
ATOM 267 CB LEU 34 143, .857 31, .440 14, .613 1, .00 50, .17 ISG 268
ATOM 268 CG LEU 34 144, .832 30, .568 13, .802 1. .00 50, .17 ISG 269
ATOM 269 CD2 LEU 34 145, .125 31, .187 12, .427 1. .00 50, .17 ISG 270
ATOM 270 CDl LEU 34 144 .335 29, .116 13, .705 1, .00 50, .17 ISG 271
ATOM 271 C LEU 34 145 .059 31, .137 16, .762 1. .00 50. .17 ISG 272
ATOM 272 O LEU 34 145 .419 32, .177 17, .314 1. .00 50. .17 ISG 273 ATOM 273 N PRO 35 145.779 30.055 16.734 1.00 48..44 ISG 274 ATOM 274 CA PRO 35 147. 046 29.972 17.408 1 .00 48. .44 ISG 275 ATOM 275 CD PRO 35 145. 150 28.752 16.607 1 .00 48, .44 ISG 276 ATOM 276 CB PRO 35 147. .363 28.478 17.539 1 .00 48. .44 ISG 277 ATOM 277 CG PRO 35 146. .331 27.773 16.639 1 .00 48, .44 ISG 278 ATOM 278 C PRO 35 148. 124 30.754 16.736 1 .00 48, .44 ISG 279 ATOM 279 O PRO 35 147. 921 31.267 15.638 1 .00 48. .44 ISG 280 ATOM 280 N ASP 36 149. 269 30.904 17.422 1 .00 44. .00 ISG 281 ATOM 281 CA ASP 36 150. 385 31.600 16.861 1 .00 44. .00 ISG 282 ATOM 282 CB ASP 36 151. ,146 32.462 17.884 1 .00 44. .00 ISG 283 ATOM 283 CG ASP 36 151. ,651 31.560 18.998 1 .00 44. .00 ISG 284 ATOM 284 ODl ASP 36 150. ,846 30.730 19.500 1 .00 44 .00 ISG 285 ATOM 285 OD2 ASP 36 152. .851 31.685 19.361 1 .00 44 .00 ISG 286 ATOM 286 C ASP 36 151. .315 30.576 16.304 1 .00 44 .00 ISG 287 ATOM 287 O ASP 36 151. .512 29.518 16.901 1 .00 44 .00 ISG 288 ATOM 288 N LEU 37 151. .888 30.842 15.113 1 .00 39 .47 ISG 289 ATOM 289 CA LEU 37 152. .774 29.851 14.582 1 .00 39 .47 ISG 290 ATOM 290 CB LEU 37 152. .406 29.317 13.185 1 .00 39 .47 ISG 291 ATOM 291 CG LEU 37 151. ,126 28.456 13.226 1.00 39.47 ISG 292 ATOM 292 CD2 LEU 37 151. .107 27.560 14.474 1.00 39.47 ISG 293 ATOM 293 CDl LEU 37 150. .919 27.661 11.927 1.00 39.47 ISG 294 ATOM 294 C LEU 37 154. .174 30.353 14.573 1.00 39.47 ISG 295 ATOM 295 O LEU 37 154. .486 31.416 14.035 1. .0 000 3 399.. .4477 ISG 296 ATOM 296 N SER 38 155. .059 29.560 15.203 1..0 000 3 355.. .1166 ISG 297 ATOM 297 CA SER 38 156. .445 29.890 15.275 1..0 000 3 355.. .1166 ISG 298 ATOM 298 CB SER 38 156. .932 30.097 16.718 1..0 000 3 355.. .1166 ISG 299 ATOM 299 OG SER 38 156, .236 31.182 17.313 1.. .0000 3 355.. .1166 ISG 300 ATOM 300 C SER 38 157. ,178 28.719 14.712 1..0 000 3 355.. .1166 ISG 301 ATOM 301 O SER 38 156, .764 27.574 14.885 1..0 000 3 355.. .1166 ISG 302 ATOM 302 N GLY 39 158, .290 28.984 14.004 1..0 000 3 333.. .5500 ISG 303 ATOM 303 CA GLY 39 159. .035 27.913 13.416 1..0 000 3 333.. .5500 ISG 304 ATOM 304 C GLY 39 160. .391 28.443 13.078 1..0 000 3 333., .5500 ISG 305 ATOM 305 O GLY 39 160. .685 29.619 13.287 1. 0 000 3 333., .5500 ISG 306 ATOM 306 N SER 40 161, .251 27.562 1 .537 1. .0000 3 344., .9966 ISG 307 ATOM 307 CA SER 40 162 .587 27.929 12.174 1.0 000 3 344 .9966 ISG 308 ATOM 308 CB SER 40 163, .639 26.987 12.792 1. .00 34, .96 ISG 309 ATOM 309 OG SER 40 164 .949 27.372 12.408 1. .00 34 .96 ISG 310 ATOM 310 C SER 40 162 .658 27.777 10.690 1. ,00 34 .96 ISG 311 ATOM 311 O SER 40 161 .803 27.126 10.091 1. ,00 34. .96 ISG 312 ATOM 312 N GLU 41 163, .649 28.418 10.039 1. 00 36, .37 ISG 313 ATOM 313 CA GLU 41 163 .726 28.273 8.616 1. 00 36, .37 ISG 314 ATOM 314 CB GLU 41 162, .942 29.348 .844 1. ,00 36, .37 ISG 315 ATOM 315 CG GLU 41 162, .987 29.161 .327 1. ,00 36. .37 ISG 316 ATOM 316 CD GLU 41 162 .178 30.282 .689 1. ,00 36, .37 ISG 317 ATOM 317 OEl GLU 41 161, .648 31.134 .450 1. ,00 36, .37 ISG 318 ATOM 318 OE2 GLU 41 162 .083 30.302 .433 1. .00 36. .37 ISG 319 ATOM 319 C GLU 41 165 .151 28.377 8.195 1. ,00 36. .37 ISG 320 ATOM 320 O GLU 41 165 .985 28.919 8.917 1. .00 36 .37 ISG 321 ATOM 321 N SER 42 165 .466 27.802 7.016 1. .00 36. .07 ISG 322 ATOM 322 CA SER 42 166 .781 27.920 6.466 1. .00 36 .07 ISG 323 ATOM 323 CB SER 42 167. .653 26.672 6.682 1. .00 36, .07 ISG 324 ATOM 324 OG SER 42 167 .097 25.563 5.991 1. .00 36. .07 ISG 325 ATOM 325 C SER 42 166 .608 28.092 4.991 1. .00 36. .07 ISG 326 ATOM 326 O SER 42 166 .024 27.246 4.316 1. ,00 36, .07 ISG 327 ATOM 327 N LEU 43 167 .114 29.214 4.451 1. .00 35, .80 ISG 328 ATOM 328 CA LEU 43 167 .041 29.459 3.042 1. .00 35, .80 ISG 329 ATOM 329 CB LEU 43 166 .367 30.807 2.715 1, .00 35 .80 ISG 330 ATOM 330 CG LEU 43 166..038 31..063 1..231 1..00 35..80 ISG 331
ATOM 331 CD2 LEU 43 167. .264 30. .891 0. .319 1. .00 35. .80 ISG 332
ATOM 332 CDl LEU 43 165. .369 32. .433 1. .046 1. .00 35. .80 ISG 333
ATOM 333 C LEU 43 168, .475 29. .511 2. .631 1. .00 35, .80 ISG 334
ATOM 334 O LEU 43 169. .289 30. .126 3. .316 1. .00 35. .80 ISG 335
ATOM 335 N GLU 44 168. .835 28. .872 1. .502 1. .00 34, .99 ISG 336
ATOM 336 CA GLU 44 170. .226 28, .796 1. .151 1. .00 34, .99 ISG 337
ATOM 337 CB GLU 44 170, .466 28, .078 -0. .188 1. .00 34, .99 ISG 338
ATOM 338 CG GLU 44 170, .127 26, .586 -0. .155 1, .00 34 .99 ISG 339
ATOM 339 CD GLU 44 168. .614 26. .437 -0. .238 1. .00 34, .99 ISG 340
ATOM 340 OEl GLU 44 167, .931 27. .460 -0. .515 1. .00 34, .99 ISG 341
ATOM 341 OE2 GLU 44 168, .120 25, .297 -0. .031 1. .00 34, .99 ISG 342
ATOM 342 C GLU 44 170, .779 30, .179 1. .025 1. .00 34, .99 ISG 343
ATOM 343 O GLU 44 171. .834 30. .482 1. .579 1. .00 34, .99 ISG 344
ATOM 344 N PHE 45 170. .081 31. .057 0. .288 1. .00 35, .84 ISG 345
ATOM 345 CA PHE 45 170. .557 32. .397 0. .122 1. .00 35, .84 ISG 346
ATOM 346 CB PHE 45 169. .780 33. .168 -0. .957 1. .00 35 .84 ISG 347
ATOM 347 CG PHE 45 170 .053 32, .506 -2. .264 1. .00 35 .84 ISG 348
ATOM 348 CDl PHE 45 169. .331 31. .400 -2. .650 1. .00 35, .84 ISG 349
ATOM 349 CD2 PHE 45 171. .030 32. .989 -3. .103 1, .00 35, .84 ISG 350
ATOM 350 CE1 PHE 45 169. .580 30. .786 -3. .855 1. .00 35 .84 ISG 351
ATOM 351 CE2 PHE 45 171 .283 32. .379 -4. .309 1, .00 35 .84 ISG 352
ATOM 352 CZ PHE 45 170. .557 31. .275 -4. .687 1. .00 35, .84 ISG 353
ATOM 353 C PHE 45 170, .440 33. .180 1. .400 1, .00 35 .84 ISG 354
ATOM 354 0 PHE 45 171, .395 33, .830 1, .823 1, .00 35 .84 ISG 355
ATOM 355 N LEU 46 169, .254 33, .133 2. .046 1, .00 40 .22 ISG 356
ATOM 356 CA LEU 46 168 .988 33 .988 3, .172 1. .00 40 .22 ISG 357
ATOM 357 CB LEU 46 167, .513 33, .933 3 , .611 1, .00 40, .22 ISG 358
ATOM 358 CG LEU 46 167, .192 34, .836 4 , .815 1, .00 40 .22 ISG 359
ATOM 359 CD2 LEU 46 165, .778 34, .569 5. .352 1, .00 40 .22 ISG 360
ATOM 360 CDl LEU 46 167, .428 36 .318 4, .474 1, .00 40 .22 ISG 361
ATOM 361 C LEU 46 169. .827 33, .667 4, .370 1. .00 40, .22 ISG 362
ATOM 362 O LEU 46 170. .523 34, .554 4 , .860 1. .00 40, .22 ISG 363
ATOM 363 N LYS 47 169. .783 32, .396 4, .846 1. .00 47 .81 ISG 364
ATOM 364 CA LYS 47 170. .490 31, .882 6, .000 1, .00 47 .81 ISG 365
ATOM 365 CB LYS 47 171. .160 32. .921 6, .927 1. .00 47 .81 ISG 366
ATOM 366 CG LYS 47 172. .200 32. .335 7, .888 1. .00 47, .81 ISG 367
ATOM 367 CD LYS 47 173. .449 31, .798 7, .187 1. .00 47, .81 ISG 368
ATOM 368 CE LYS 47 174, .487 31, .213 8, .147 1. .00 47, .81 ISG 369
ATOM 369 NZ LYS 47 175, .657 30. .717 7, .388 1. .00 47 .81 ISG 370
ATOM 370 C LYS 47 169, .479 31. .152 6, .830 1. .00 47, .81 ISG 371
ATOM 371 O LYS 47 168. .366 30. .885 6. .379 1. .00 47. .81 ISG 372
ATOM 372 N VAL 48 169. .856 30. .782 8. .072 1. .00 54, .46 ISG 373
ATOM 373 CA VAL 48 168, .922 30. .130 8. .940 1. .00 54, .46 ISG 374
ATOM 374 CB VAL 48 169, .555 29. .137 9. .873 1. .00 54, .46 ISG 375
ATOM 375 CGI VAL 48 170. .152 27. .996 9. .033 1. .00 54. .46 ISG 376
ATOM 376 CG2 VAL 48 170. .590 29. .862 10. .750 1. .00 54. .46 ISG 377
ATOM 377 C VAL 48 168. .301 31. .210 9. .755 1. .00 54. .46 ISG 378
ATOM 378 0 VAL 48 168, .991 32. .051 10. .332 1. .00 54. .46 ISG 379
ATOM 379 N ASP 49 166. .959 31. .240 9. ,799 1. .00 61. .20 ISG 380
ATOM 380 CA ASP 49 166. .360 32. .310 10. .524 1. .00 61. .20 ISG 381
ATOM 381 CB ASP 49 166. .074 33. .551 9. .661 1. .00 61. .20 ISG 382
ATOM 382 CG ASP 49 165. .068 33. .164 8. .584 1. .00 61. .20 ISG 383
ATOM 383 ODl ASP 49 164. .874 31. .939 8, .365 1. .00 61. .20 ISG 384
ATOM 384 OD2 ASP 49 164. .479 34. .092 7. ,967 1. .00 61. .20 ISG 385
ATOM 385 C ASP 49 165. .063 31. .873 11. .104 1. .00 61. .20 ISG 386
ATOM 386 O ASP 49 164. .486 30. .852 10. .729 1. .00 61. .20 ISG 387 ATOM 387 N TYR 50 164,.615 32.657 12..097 1..00 70..02 ISG 388
ATOM 388 CA TYR 50 163 .378 32 .469 12. .772 1, .00 70. .02 ISG 389
ATOM 389 CB TYR 50 163 .098 30 .987 13 .101 1. .00 70 .02 ISG 390
ATOM 390 CG TYR 50 164 .222 30 .448 13 .929 1. .00 70, .02 ISG 391
ATOM 391 CDl TYR 50 165 .363 29 .967 13 .330 1, .00 70 .02 ISG 392
ATOM 392 CD2 TYR 50 164, .148 30 .421 15 .303 1. .00 70, .02 ISG 393
ATOM 393 CE1 TYR 50 166 .405 29 .471 14 .078 1. .00 70 .02 ISG 394
ATOM 394 CE2 TYR 50 165 .183 29 .927 16. .061 1. .00 70 .02 ISG 395
ATOM 395 CZ TYR 50 166 .315 29 .450 15 .448 1, .00 70 .02 ISG 396
ATOM 396 OH TYR 50 167, .381 28 .941 16. .221 1, .00 70, .02 ISG 397
ATOM 397 C TYR 50 163 .514 33 .228 14 .054 1, .00 70 .02 ISG 398
ATOM 398 O TYR 50 164, .508 33 .083 14, .747 1, .00 70. .02 ISG 399
ATOM 399 N VAL 51 162 .591 34 .129 14 .438 1, .00 71 .54 ISG 400
ATOM 400 CA VAL 51 162. .720 34. .456 15, .838 1, .00 71. .54 ISG 401
ATOM 401 CB VAL 51 162 .208 35 .813 16 .239 1, .00 71 .54 ISG 402
ATOM 402 CGI VAL 51 162. .272 35. .923 17, .774 1, .00 71. .54 ISG 403
ATOM 403 CG2 VAL 51 163 .047 36 .892 15, .547 1, .00 71 .54 ISG 404
ATOM 404 C VAL 51 161, .755 33. .464 16 .368 1, .00 71. .54 ISG 405
ATOM 405 O VAL 51 160, .728 33 .817 16 .951 1, .00 71 .54 ISG 406
ATOM 406 N ASN 52 162 .141 32 .178 16 .218 1 .00 75 .23 ISG 407
ATOM 407 CA ASN 52 161, .165 31. .155 16, .233 1, .00 75 .23 ISG 408
ATOM 408 CB ASN 52 160 .486 30 .978 17 .602 1 .00 75 .23 ISG 409
ATOM 409 CG ASN 52 159. .717 29, .666 17, .579 1, .00 75 .23 ISG 410
ATOM 410 ODl ASN 52 159 .180 29 .229 18 .596 1 .00 75 .23 ISG 411
ATOM 411 ND2 ASN 52 159, .665 29, .014 16, .387 1, .00 75 .23 ISG 412
ATOM 412 C ASN 52 160 .196 31, .754 15 .267 1 .00 75 .23 ISG 413
ATOM 413 O ASN 52 159, .021 31, .813 15, .629 1, .00 75 .23 ISG 414
ATOM 414 N TYR 53 160, .728 32, .206 14, .064 1, .00 76 .43 ISG 415
ATOM 415 CA TYR 53 160, .131 33 , .083 13, .055 1, .00 76 .43 ISG 416
ATOM 416 CB TYR 53 160. .484 32, .785 11. .569 1 .00 76 .43 ISG 417
ATOM 417 CG TYR 53 159, .444 31, .947 10, .897 1. .00 76, .43 ISG 418
ATOM 418 CDl TYR 53 159, .341 30. .594 11, .112 1, .00 76 .43 ISG 419
ATOM 419 CD2 TYR 53 158, .552 32 , .541 10. .033 1. .00 76, .43 ISG 420
ATOM 420 CE1 TYR 53 158, .370 29, .850 10. .483 1, .00 76, .43 ISG 421
ATOM 421 CE2 TYR 53 157. .577 31. .806 9. .399 1, .00 76, .43 ISG 422
ATOM 422 CZ TYR 53 157. .484 30, .455 9. .625 1, .00 76, .43 ISG 423
ATOM 423 OH TYR 53 156. .486 29 .693 8. .980 1 .00 76 .43 ISG 424
ATOM 424 C TYR 53 158, .671 32, .984 13. .250 1, .00 76, .43 ISG 425
ATOM 425 O TYR 53 158, .124 31, .886 13, .271 1, .00 76, .43 ISG 426
ATOM 426 N ASN 54 157. . 911 34 , .107 13. .478 1, .00 67. .48 ISG 427
ATOM 427 CA ASN 54 156. .658 33 , .783 13. .903 1, .00 67, .48 ISG 428
ATOM 428 CB ASN 54 156. .544 33. .617 15. ,428 1. .00 67. .48 ISG 429
ATOM 429 CG ASN 54 156, .885 34. .954 16. .070 1. .00 67. .48 ISG 430
ATOM 430 ODl ASN 54 157. .871 35. .595 15. .708 1. .00 67. .48 ISG 431
ATOM 431 ND2 ASN 54 156. .046 35. .393 17. .046 1. .00 67. .48 ISG 432
ATOM 432 C ASN 54 155. .645 34. .789 13. ,508 1. .00 67. .48 ISG 433
ATOM 433 O ASN 54 155, .931 35. .958 13. ,254 1. .00 67. .48 ISG 434
ATOM 434 N PHE 55 154. .400 34. .285 13. ,436 1. .00 61. .19 ISG 435
ATOM 435 CA PHE 55 153. .234 35. .075 13. ,215 1. .00 61. .19 ISG 436
ATOM 436 CB PHE 55 152. .419 34. ,634 11. 988 1. ,00 61. ,19 ISG 437
ATOM 437 CG PHE 55 153. .220 34. .981 10. .779 1. .00 61. ,19 ISG 438
ATOM 438 CDl PHE 55 154. .320 34. .235 10. .429 1. .00 61. .19 ISG 439
ATOM 439 CD2 PHE 55 152. .866 36. .049 9. .988 1. .00 61. .19 ISG 440
ATOM 440 CE1 PHE 55 155. .058 34. .553 9. ,313 1. .00 61. .19 ISG 441
ATOM 441 CE2 PHE 55 153. .600 36. .370 8. 871 1. ,00 61. .19 ISG 442
ATOM 442 CZ PHE 55 154. .700 35. .622 8. ,531 1. .00 61. ,19 ISG 443
ATOM 443 C PHE 55 152. .401 34. .831 14. 433 1. .00 61. ,19 ISG 444 ATOM 444 O PHE 55 152.118 33.681 14.768 1..00 61,.19 ISG 445
ATOM 445 N SER 56 151 .994 35 .904 15 .140 1. .00 51, .14 ISG 446
ATOM 446 CA SER 56 151 .268 35 .683 16 .357 1. .00 51, .14 ISG 447
ATOM 447 CB SER 56 152 .189 35 .491 17 .576 1. .00 51, .14 ISG 448
ATOM 448 OG SER 56 153 .073 34 .401 17 .357 1. .00 51, .14 ISG 449
ATOM 449 C SER 56 150 .417 36 .882 16 .648 1, .00 51, .14 ISG 450
ATOM 450 O SER 56 150 .363 37 .832 15 .868 1. .00 51 .14 ISG 451
ATOM 451 N ASN 57 149 .722 36 .843 17 .807 1. .00 42, .47 ISG 452
ATOM 452 CA ASN 57 148 .879 37 .918 18 .255 1, .00 4 .47 ISG 453
ATOM 453 CB ASN 57 149 .658 39 .196 18 .616 1. .00 42 .47 ISG 454
ATOM 454 CG ASN 57 150 .476 38 .921 19 .870 1. .00 42 .47 ISG 455
ATOM 455 ODl ASN 57 150 .056 38 .170 20 .748 1. .00 42 .47 ISG 456
ATOM 456 ND2 ASN 57 151, .680 39. .548 19. .960 1. .00 42 , .47 ISG 457
ATOM 457 C ASN 57 147, .914 38, .252 17. .172 1. .00 42, .47 ISG 458
ATOM 458 O ASN 57 147, .730 39, .416 16, .823 1. .00 42, .47 ISG 459
ATOM 459 N ILE 58 147. .229 37, .223 16, .647 1. .00 39, .32 ISG 460
ATOM 460 CA ILE 58 146, .352 37, .417 15 .537 1, .00 39, .32 ISG 461
ATOM 461 CB ILE 58 146, .349 36, .219 14 .631 1. .00 39, .32 ISG 462
ATOM 462 CG2 ILE 58 147, .822 35, .838 14 .399 1, .00 39, .32 ISG 463
ATOM 463 CGI ILE 58 145. .625 35, .025 15 .262 1. .00 39. .32 ISG 464
ATOM 464 CDl ILE 58 145, .420 33, .900 14 .257 1, .00 39, .32 ISG 465
ATOM 465 C ILE 58 144 .967 37, .580 16 .088 1. .00 39, .32 ISG 466
ATOM 466 O ILE 58 144. .542 36, .852 16 .985 1, .00 39. .32 ISG 467
ATOM 467 N LYS 59 144, .232 38, .593 15 .592 1, .00 35. .71 ISG 468
ATOM 468 CA LYS 59 142, .892 38, .810 16 .057 1. .00 35. .71 ISG 469
ATOM 469 CB LYS 59 142 .720 40, .121 16 .837 1, .00 35. .71 ISG 470
ATOM 470 CG LYS 59 143 .436 40, .143 18 .189 1, .00 35, .71 ISG 471
ATOM 471 CD LYS 59 142, .922 39. .091 19 .173 1. .00 35, .71 ISG 472
ATOM 472 CE LYS 59 143 .593 39. .157 20 .547 1. .00 35, .71 ISG 473
ATOM 473 NZ LYS 59 143 .189 40. .395 21 .253 1. .00 35, .71 ISG 474
ATOM 474 C LYS 59 142 .010 38. .905 14 .854 1. .00 35, .71 ISG 475
ATOM 475 O LYS 59 142 .480 39. .163 13 .748 1. .00 35, .71 ISG 476
ATOM 476 N ILE 60 140, .694 38. .696 15 .049 1, .00 35, .55 ISG 477
ATOM 477 CA ILE 60 139 .765 38, .764 13 .960 1, .00 35, .55 ISG 478
ATOM 478 CB ILE 60 138, .664 37, .750 14 .075 1. .00 35, .55 ISG 479
ATOM 479 CG2 ILE 60 137, .586 38, .073 13 .029 1. .00 35, .55 ISG 480
ATOM 480 CGI ILE 60 139 .227 36, .322 13, .980 1, .00 35, .55 ISG 481
ATOM 481 CDl ILE 60 138, .199 35, .249 14, .337 1, .00 35, .55 ISG 482
ATOM 482 C ILE 60 139, .133 40, .112 14, .033 1. .00 35, .55 ISG 483
ATOM 483 O ILE 60 138, .421 40. .424 14, .987 1. .00 35. .55 ISG 484
ATOM 484 N SER 61 139, .455 40. .992 13, .065 1. .00 35. .55 ISG 485
ATOM 485 CA SER 61 138, .843 42. .288 13, .084 1. .00 35. .55 ISG 486
ATOM 486 CB SER 61 139, .577 43. .352 12, .246 1. .00 35. .55 ISG 487
ATOM 487 OG SER 61 140, .763 43. .777 12, .901 1. .00 35. .55 ISG 488
ATOM 488 C SER 61 137, .447 42. .213 12, .570 1. .00 35. .55 ISG 489
ATOM 489 O SER 61 136, .511 42. .711 13. .198 1. .00 35. .55 ISG 490
ATOM 490 N ALA 62 137, .268 41. .585 11. .391 1. .00 38. .43 ISG 491
ATOM 491 CA ALA 62 135, .955 41. .564 10. .820 1. .00 38. .43 ISG 492
ATOM 492 CB ALA 62 135, .768 42. .597 9. .701 1. .00 38. .43 ISG 493
ATOM 493 C ALA 62 135, .702 40. .218 10, .229 1. .00 38. .43 ISG 494
ATOM 494 O ALA 62 136, .602 39. .598 9, .662 1. .00 38. .43 ISG 495
ATOM 495 N PHE 63 134, .448 39. .739 10, .367 1. .00 44. .87 ISG 496
ATOM 496 CA PHE 63 134, .064 38. .454 9. .861 1. .00 44. .87 ISG 497
ATOM 497 CB PHE 63 133, .852 37. .481 11. .035 1. .00 44. .87 ISG 498
ATOM 498 CG PHE 63 134. .090 36. .072 10. .620 1. ,00 44. .87 ISG 499
ATOM 499 CDl PHE 63 133. .242 35. .425 9. .758 1. ,00 44. ,87 ISG 500
ATOM 500 CD2 PHE 63 135. .170 35. .395 11. .142 1. ,00 44. ,87 ISG 501 ATOM 501 CE1 PHE 63 133..485 34,.120 9..405 1..00 44..87 ISG 502
ATOM 502 CE2 PHE 63 135. .414 34, .092 10. .793 1. .00 44. .87 ISG 503
ATOM 503 CZ PHE 63 134. .570 33, .450 9. .920 1. .00 44. .87 ISG 504
ATOM 504 C PHE 63 132. .717 38, .696 9. .258 1. .00 44. .87 ISG 505
ATOM 505 O PHE 63 131. .704 38, .634 9. .951 1. .00 44. ,87 ISG 506
ATOM 506 N SER 64 132, .629 38, .937 7, .942 1, .00 48. .12 ISG 507
ATOM 507 CA SER 64 131. .312 39 .282 7. .507 1. .00 48. .12 ISG 508
ATOM 508 CB SER 64 131. .249 40, .597 6. .708 1. .00 48. .12 ISG 509
ATOM 509 OG SER 64 131. .970 40, .474 5. .489 1. .00 48. .12 ISG 510
ATOM 510 C SER 64 130. .760 38, .215 6. .636 1. .00 48. .12 ISG 511
ATOM 511 O SER 64 131. .432 37, .736 5. .724 1. .00 48. .12 ISG 512
ATOM 512 N PHE 65 129. .521 37 .775 6. .943 1. .00 51. .02 ISG 513
ATOM 513 CA PHE 65 128, .875 36 .925 5, .995 1. .00 51. .02 ISG 514
ATOM 514 CB PHE 65 128, .717 35, .433 6. .363 1, .00 51. .02 ISG 515
ATOM 515 CG PHE 65 128, .152 35. .230 7, .719 1, .00 51. .02 ISG 516
ATOM 516 CDl PHE 65 126. .805 35. .339 7. .965 1. .00 51. .02 ISG 517
ATOM 517 CD2 PHE 65 129. .004 34, .893 8. .746 1. .00 51. .02 ISG 518
ATOM 518 CE1 PHE 65 126. .332 35, .126 9. .235 1. .00 51. .02 ISG 519
ATOM 519 CE2 PHE 65 128, .530 34 .680 10. .015 1, .00 51. .02 ISG 520
ATOM 520 CZ PHE 65 127, .188 34 .799 10, .258 1, .00 51, .02 ISG 521
ATOM 521 C PHE 65 127, .618 37 .579 5, .533 1, .00 51. .02 ISG 522
ATOM 522 O PHE 65 126, .598 37, .685 6, .214 1, .00 51, .02 ISG 523
ATOM 523 N PRO 66 127. .784 38, .079 4 , .340 1. .00 49, .26 ISG 524
ATOM 524 CA PRO 66 126. .766 38, .822 3 , .654 1, .00 49, .26 ISG 525
ATOM 525 CD PRO 66 129. .116 38 .413 3 .869 1 .00 49. .26 ISG 526
ATOM 526 CB PRO 66 127. .456 39 .476 2, .458 1, .00 49, .26 ISG 527
ATOM 527 CG PRO 66 128. .924 39 .586 2, .897 1, .00 49, .26 ISG 528
ATOM 528 C PRO 66 125, .560 38, .037 3, .260 1, .00 49, .26 ISG 529
ATOM 529 O PRO 66 124, .463 38, .593 3. .290 1, .00 49. .26 ISG 530
ATOM 530 N ASN 67 125, .720 36, .755 2, .887 1, .00 42. .73 ISG 531
ATOM 531 CA ASN 67 124. .568 36, .044 2. .420 1, .00 42. .73 ISG 532
ATOM 532 CB ASN 67 124, .633 35 .695 0, .923 1, .00 42, .73 ISG 533
ATOM 533 CG ASN 67 123. .355 34, .957 0, .553 1 .00 42, .73 ISG 534
ATOM 534 ODl ASN 67 122. .338 35, .562 0, .219 1, .00 42, .73 ISG 535
ATOM 535 ND2 ASN 67 123, .409 33. .598 0, .611 1, .00 42, .73 ISG 536
ATOM 536 C ASN 67 124, .446 34. .759 3 , .162 1, .00 42, .73 ISG 537
ATOM 537 O ASN 67 125. .439 34, .100 3 , .463 1. .00 42, .73 ISG 538
ATOM 538 N THR 68 123 .191 34 .399 3, .494 1, .00 36, .72 ISG 539
ATOM 539 CA THR 68 122, .889 33 .163 4, .149 1, .00 36, .72 ISG 540
ATOM 540 CB THR 68 122, .714 33, .313 5, .630 1, .00 36, .72 ISG 541
ATOM 541 OGl THR 68 122, .518 32, .042 6, .232 1. .00 36, .72 ISG 542
ATOM 542 CG2 THR 68 121, .511 34, .235 5. .893 1, .00 36. .72 ISG 543
ATOM 543 C THR 68 121, .582 32, .703 3. .585 1, .00 36. .72 ISG 544
ATOM 544 O THR 68 120, .775 33 .517 3, .141 1, .00 36. .72 ISG 545
ATOM 545 N SER 69 121, .343 31, .376 3 , .556 1, .00 32. .57 ISG 546
ATOM 546 CA SER 69 120, .079 30, .931 3, .043 1, .00 32. .57 ISG 547
ATOM 547 CB SER 69 120, .051 30, .786 1, .512 1, .00 32. .57 ISG 548
ATOM 548 OG SER 69 120. .932 29. .751 1. .102 1, .00 32. .57 ISG 549
ATOM 549 C SER 69 119. .769 29. .586 3. .621 1, .00 32. .57 ISG 550
ATOM 550 O SER 69 120. .667 28. .821 3. .970 1, .00 32. .57 ISG 551
ATOM 551 N LEU 70 118. .464 29. .283 3. .762 1 .00 30. .57 ISG 552
ATOM 552 CA LEU 70 118, .053 27, .985 4. .218 1, .00 30. .57 ISG 553
ATOM 553 CB LEU 70 117, .270 27, .982 5. .544 1, .00 30. .57 ISG 554
ATOM 554 CG LEU 70 118, .140 28. .241 6. .786 1, .00 30. .57 ISG 555
ATOM 555 CD2 LEU 70 119. .328 27. .270 6. .843 1. .00 30. .57 ISG 556
ATOM 556 CDl LEU 70 117. .298 28. .216 8. ,073 1. .00 30. ,57 ISG 557
ATOM 557 C LEU 70 117. .154 27, .413 3. .178 1. .00 30. .57 ISG 558 ι-. 3 H H H H H H H H H >-_ H H H H ι-3 H H H ι-3 ι-_ H H H >-_ H H H H H H H H μ- H H H ι^ H H μ- ι^ H H 3 ι^H H H H iH H H . H P PPO PP P PP P P P P O O P P PP PP P PP PP PO d PP P dd P P PP P P P PPPP P PP P PP OQ P Pd d 223332222232333223333322333332223333333333223333223332233
σi σi σi σi σi σi σi m m σi σi σi σi en cn in ui in in in in ui in ui ui in -i -i in in ui in in -i in i^ ui in in -i in u^
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Ω Ω a P Ω Ω Ω Ω Ω Ω a P Ω Ω Ω Ω a P Ω Ω a P Ω Ω Ω Ω Ω 3 P Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω 3 P Ω Ω Ω a C0 > d Ω Ω ta > a P Ω Ω Ω Ω Ω ro > > Ω ω > Ω Ω N Cd c_ d d Ω ω > ro
H H tO to H to H ω > t H t H
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Figure imgf000531_0001
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H H H H H H H H H H H H H H H H H H H H H H H H H H tO tO H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H O O 00 VO 00 4* σi σi σi ui ui ui ui ui ui ui ^i σi ui ui uJ to H to to to to to to to 4* 4* σι σι -j 01
VD UJ O_ H i^ _1 0 H 01 VO Cn 4* CO _l UJ UJ t VD ln H H ^ UI VD U1 4* lO H W lO iJ> OO H VD O ln U1 i^ H OO Cn in VD ^ UJ VD 01 UJ _l H VD On 0 4* -J Ul H θ H vo cD ω to vo uJ o ιn 4* H - vo vD σ3 vD ιt* uJ UJ o σι o uι oo ιo vo cn ^ o to vo o uι o vD ui H uι vo 4* ^ σ ιn vo σι o vD 4* ^ H to eD uι o to to
OJ 0 01 U . (n φ O) ^ sl * U 01 ^ μ (I1 01 01 0 CO * μ iD ιlι M W U OI CIl M 01 l U U ID U l ι|ι {Jl B * IO ^ M W Ul CO (Jl * O O O ^ IO W 01 0 to o to to to to to t t to to to to to to H H H H H H H H H H H H H H H H tO tO IO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO
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UJ 4* 4* 01 Ul C» ^i en ^i σ σi 4* σi σi Ul ^i σi t0 4* UJ 4* 4* 4* 4* Ul UJ H tO O O O H H Ul tO H H tO H tO O H tO H H O O O tO tO H Ul tO O H tO tO i^ ^l VO - lD tO UI UI O H -J VD O ^l ^l tO O ^l Ul VD VD Ul VD ln VD I Ol H VD O tO ifc H H O OO UJ H 01 t Ul Ul H 4* 4* O H ln O tO ^3 H tO UJ 01 cn 00 4* 01 H Ul -J 01 tO Ul UJ Ul H M UJ H O Ul ^l lD VD ι^ VD H ^1 0 UI 4* tO O O OO ^J UI 4* OO U1 00 00 H 4* OO O tO tt* 4* -J OO H VO ^j en t VO U1 01 4* 4* 4* C0 4* 4i tO O OO OO VD Ul Cn Cn ^J H 4* 01 VO H H H 4* Ul H Ul Cn -J 0 00 ^1 00 t0 01 4* 01 UJ tO UI tO H -J H VO O H tO t0 4* 01 0 0 00 -J H Ul H H tO
H H H H H H H H H H H H H H H
O O O O O O O O O O O O O O O O O o o o o o o o oo ooo oo o o o oo o o o o o o oo o o o o o o o o O O O O O O O O O O O O O O O O O o o o o o o o oo o oo o o oo o oo o o o o o o oo o o o o o o o o
Ul l UJ Ul H H Ul Ul ui σi σi σi σi σi σi σi σi σi σi cn en σi σi oi σi σi σi σi σi oi σi σi σi σi to to to to to o
H H H -i σ σi cn cn cn cn σi H H H H -j ^ ^j ^j -j ^i -j o o o o ui ui ui ui ui uπ ui oo oo oo co co oo oo σi σi σi σi σi σi σi σi en cn σi io vD VD VD VD Ui σι σι σ o o o o o o o o σ σι σι σi 4* 4* ι^. 4* ι^ ιt* ι^ _ι _ι _ι uι oo oo oo oo oo oo oo o o o o o o o cn σι σι σι σι σ σι σι σι σι σι to to to to to -j
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to CD to to to to
Ω Ω Ώ Ώ Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ώ Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω
-i cn cn σι cn cn σι σι σι σι σι σι σι σι σ σι ιn ιn uι uι uι uι uι uι uι uι uι ιn ιn ui -i uι uι ιn ιn uι uι uι ιn ιn uι uι uι uι uι uι uι ui -i -1 -^
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σi σi σi en en en en cn cn o σi σi σi σi σi σi cn cn σ σi σi σi σi σi σi σ σ σi σi σi σi cn cn σi σi σi σi σi σi σi σi en cn σi σi σi σi σi σi σi σi σi σi σi σi σi σi -j -j σι σι σι σι σι σ σι σι σ σι ιn uι uι uι uι uι uι ιn ui 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* ω uι UJ UJ UJ UJ uι uι ω uι to to to to to to to to to tθ H H H H H H o vD ∞ -j σι ui 4* ω H θ io oo -j σι ιn 4* UJ tθ H o ιo ∞ -j σι uι 4* uι tθ H θ io ∞ -j σι uι 4* ω tθ H θ vD θo ~] σι uι 4* uJ tθ H θ vo oo -4 en uι
Ω a O Ω n O Ω Ω a P Ω Ω a P Ω Ω Ω Ω Ω Ω a O Ω P Ω Ω Ω a P Ω Ω P Ω Ω 3 P Ω Ω Ω Ω Ω Ω 3 Ω ΩΩ 3 PΩ3 ΩΩ Ω
> Ω ro d Ω ω Ώ Ω d d Ω ω > ro > N w o o to >
H > ro d cd ro Ω
H to to to H ro > H to ι-_ H H H H i_ H_ Ω Ω Ω Ω a a a ffi ffi H H ι-3 H ι-3 H H CH CH H tH H H CH CH > > tπ IT1 H H H H H H H H H H H m m to to to to to to a a a c M . d d C- . c- CH ι ι
> Jι !d ! !- !- J3 ftl !d «; >< to m to to to to to to to to a a a a w w ϊo ϊu ^u jo fα σ σ c α α α Q c. S;' > to to to to to to
00 _3 O1 00 00 00 00 00 00 00 O0 _l _3 _3 00 _l _1 00 00 C0 C0 00 00 00 00 C0 00 00 C0 CO CD CD CO CO CO 00 00 00 O0 00 00 O0 00 00 O3 03 O^ ^1 ^1 01 01 01 01 01 01 01 Ul Ul Ul Ul 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* Ul UI UI UJ UI UI UJ UI tO tO tO tO tO tO tO H H H H H H H H O O O O O VD VO VO VO VD VD
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ω iv ω ϋj ω u i U ι ω u ω _ ω ω ω iv ω ι ω u u _ u _ NJ M tJ J M M i. ω u to ι j ι M i ι u i M i u )J Ki >o kJ M )j μ μ t
^ Cn 4* ln 01 ι^ 4* Ul UJ ι^ ω tO H H H UJ tO UJ O tO M O VD O VD ^ VD CD ^ OO ^ eD -O CD Cn -J -i σ Ul ιt> Ul cn _l ι^ 4* ljJ 4* Ul tO H H VO O lO OO OO O
4* OO lD Cn U1 4* VD O Q- i^ Cn tO CD UJ UJ VD ^ lD ^ O eD VD 01 00 ^ it> UI H to il* _3 tO <n t CD Cn ^ H VO OO ^ -J 4* M 4* tO H M tO lD On VD On W ^ VO ^ W 01 0- it. Ul H <n V0 4* M VO tO C» ^ tO -J 4* ln ^ H O ^ H UJ Ul tO VD Cn en o 0 4v. H ^ UI Ul C» VO Ul UJ 4* V0 ^1 -O VD Ul tO H U1 0 01 0 H H 01 4* ui ι& σ H UJ H Uι vo ^ iD H θ o vo cn ^ H to oo o vo cn uι to ιo H N) oo cn H θo m o uι ιo uj vD θ Vθ ιt cD iΛJ o ιn -j cn cn vo to 4* o -j oo -j -i oo oo
Figure imgf000532_0001
-i _i ιt* to to uι uι
H θ θ _ι iD θo 4* -o to σ o uι en 4* CD 4* H H ^ σ vD to ω cD -j eD io -i H H vo vo -J H to vo on uJ 4* ui H eD en vo -J θo cn oo 4* o 4* -i σi H tθ ιt* H U σι σι uJ uι -j -j oo to oo to oo vD CD -J H 4* -i o _ι m ιf* H VD θ vo oo cD H 4* uι vD H vo vo vo oo o to uι ^ uj -j to to M to o to ^ ιn <n vo to to ω -j H H _ι UJ uι uι UJ θ3 ^ m ι^ σι σ o 4* uι D to uι co oo ^ σι ^ oo ιn ιn cD UJ o o cn uj ^ H in to cn ui H H ui ι^ o uj -j cn σι to oo en 4* 4* 4*
^ U1 01 Ul UJ tO UJ ιt. 4* tO UJ UJ tO H H H M tO O H O O O O O UJ tO H O O H tO tO ιt* σi 4* UI UJ UJ UI O H H tO UI ι& Ul Ul -J Ul ln 4* 4* O O H tO
NJ IO Ol -] uι oo u ι^ _3 σι c» ιn oo on H M to cn o 4* u ιn to 4* o o vo σ ι& ~j o 4* σι o oo -i σι σι σι oo σι o o uι co H θ to oo on H θo ιt* ~j vo to in 4* to to vo O H -J O e» ln W U1 00 _l ^l tO ^l H lO tO UJ O ^J UI l0 VD VD 4* 01 it -J H -l H H UJ -l ^l H H UJ VD H O 00 0n 01 ~J H ^J -J Ul -J V0 O O to o vo on H * w en en H θo uι ιn oo _3 vo uJ θo ιo ιn ^ oo cD 4* H θ H vo σι ^ι oo to vD ^ι -J vo -i H θ UJ θ oo ω -j iD θo on vD uι -j o uι oo to vo o oo
H H H H H H H H H H H H H H o oo o o o o o o o o oo o o o o o o o o oo o oo o oo o o oo o o o oo o o o o o o oo o o o oo o o o o oo o o o o o o o o o o o oo o o o o o o o o oo o o o o oo o o o o o o o o o o o o o o o oo o o o o o o o o o oo
_ κι ι M M M M kJ J ω u u u iιj ω iΛi ω ω u u u u u u u u u u u u u u u ι>J i u ω u ι* ^ ιi* j* ^ ιt* <* » u ω u u u u u u u ω ω j j oι oi (» co co co co H μ μ ιn w ιn ιn ιn iJi oι iJi ιn (Λ ^ ^ j J ^ J ^ -j Φ iD io iD iD iD - θ o o o o o o o ci) Co aι _ iD iD ii) _ - _ oι on σ ^ ^ ^ ^ ^ ^ -j to w to to cn en en cn m cn en cn σ σi iD VD VD io vD vo io vD Ui ui ui ui ui ui ui σi σi σi σi σi σi σi cn σi σi σ σi σi H H H H H H
OO OO UI UI UJ UJ UJ UJ UJ -J -J -J -J W UI UI UI UI UJ UJ UI UJ UJ IO tO tO tO tO tO tO tO lD lO O VO VD VD VD VO VO VO VD VO VO VO VD OO OO OO OO OO On O^
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H to to to to to to to W to to to to to to to to to m to to to to to to to to to m to to to W to to to to to W to to m to to to m to to to to to to to CD to to to to Ω Ώ Ω Ω Ω Ω Ώ Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω σi σi σ cn σi cn σi σi cn σ cn tn σ σi σ σi σi σi σi σi σi σ σ σi cn σi σi σ σi σi σi cn cn cn σi cn cn cn en cn cn cn σi σi σi σi σi σi σi σi cn c^ ^ ^ -4 -i -i σι σι σι σι σι σι σι σι uι uι uι uι _ι uι uι uι _ι ι^ 4* 4* 4* 4* 4* 4* 4* 4* 4* uj ω uJ UJ UJ uι uι uj ω uJ to to to to to to to to to tθ H H H H
10 H O VO CD ^ en U1 4* UJ tO H O VO OO -J Cn Ul 4* UJ tO H O VD CD -j σi Ul 4* UJ tO H O VD αi -J 01 U1 4* UJ tO H O VD OD -j σ _1 4* UJ tO H O VD OO -J θn
ATOM 672 CB ALA 87 137.879 35.749 7.806 1.00 27.68 ISG 673
ATOM 673 C ALA 87 138 .659 37 .970 7. .173 1, .00 27 .68 ISG 674
ATOM 674 O ALA 87 139 .641 37 .627 6 .516 1 .00 27 .68 ISG 675
ATOM 675 N ASN 88 138 .642 39 .113 7 .879 1, .00 29 .73 ISG 676
ATOM 676 CA ASN 88 139 .786 39 .974 7. .867 1, .00 29 .73 ISG 677
ATOM 677 CB ASN 88 139 .422 41 .467 7 .785 1, .00 29 .73 ISG 678
ATOM 678 CG ASN 88 140 .707 42 .265 7, .623 1, .00 29 .73 ISG 679
ATOM 679 ODl ASN 88 141 .802 41 .704 7 .609 1 .00 29 .73 ISG 680
ATOM 680 ND2 ASN 88 140, .575 43, .613 7, .507 1, .00 29 .73 ISG 681
ATOM 681 C ASN 88 140 .483 39 .754 9 .169 1, .00 29 .73 ISG 682
ATOM 682 O ASN 88 139, .883 39, .881 10, .235 1, .00 29 .73 ISG 683
ATOM 683 N ILE 89 141 .782 39 .406 9 .109 1 .00 32 .17 ISG 684
ATOM 684 CA ILE 89 142, .525 39, .121 10, .305 1, .00 32 .17 ISG 685
ATOM 685 CB ILE 89 143 .022 37 .704 10 .344 1, .00 32 .17 ISG 686
ATOM 686 CG2 ILE 89 143, .964 37, .550 11, .549 1, .00 32 .17 ISG 687
ATOM 687 CGI ILE 89 141 .839 36 .721 10 .346 1 .00 32 .17 ISG 688
ATOM 688 CDl ILE 89 142, .249 35, .276 10, .062 1, .00 32 .17 ISG 689
ATOM 689 C ILE 89 143 .737 40 .004 10 .316 1 .00 32 .17 ISG 690
ATOM 690 O ILE 89 144, .267 40 .351 9. .262 1, .00 32 .17 ISG 691
ATOM 691 N SER 90 144, .188 40. .423 11, .520 1. .00 35 .55 ISG 692
ATOM 692 CA SER 90 145 .379 41 .224 11, .615 1, .00 35 .55 ISG 693
ATOM 693 CB SER 90 145, .120 42. .707 11. .931 1, .00 35 .55 ISG 694
ATOM 694 OG SER 90 144, .483 43. .328 10. .823 1, .00 35 .55 ISG 695
ATOM 695 C SER 90 146, .238 40, .642 12, .695 1, .00 35 .55 ISG 696
ATOM 696 O SER 90 145, .733 40, .066 13 .659 1, .00 35 .55 ISG 697
ATOM 697 N THR 91 147, .578 40, .752 12, .543 1, .00 37 .58 ISG 698
ATOM 698 CA THR 91 148, .461 40, .104 13, .475 1 .00 37 .58 ISG 699
ATOM 699 CB THR 91 148, .831 38, .726 13, .014 1, .00 37 .58 ISG 700
ATOM 700 OGl THR 91 149, .756 38, .818 11 .941 1 .00 37 .58 ISG 701
ATOM 701 CG2 THR 91 147, .564 38, .034 12, .484 1, .00 37 .58 ISG 702
ATOM 702 C THR 91 149, .777 40, .827 13 .489 1 .00 37 .58 ISG 703
ATOM 703 O THR 91 149, .944 41, .881 12, .876 1, .00 37 .58 ISG 704
ATOM 704 N ASP 92 150. .751 40. .248 14. .227 1, .00 38, .70 ISG 705
ATOM 705 CA ASP 92 152. .099 40. .739 14. .304 1, .00 38 .70 ISG 706
ATOM 706 CB ASP 92 152. .498 41. .213 15. .712 1. .00 38. .70 ISG 707
ATOM 707 CG ASP 92 151. .701 42. .470 16. .028 1, .00 38 .70 ISG 708
ATOM 708 ODl ASP 92 151. .035 42. , 997 15. .096 1. .00 38, .70 ISG 709
ATOM 709 OD2 ASP 92 151. .748 42. .922 17, .203 1. .00 38 .70 ISG 710
ATOM 710 C ASP 92 152. .988 39. .579 13. .961 1. .00 38, .70 ISG 711
ATOM 711 O ASP 92 152. .554 38. .430 14, .012 1. .00 38, .70 ISG 712
ATOM 712 N TRP 93 154. .251 39. .851 13. .566 1. .00 41. .60 ISG 713
ATOM 713 CA TRP 93 155. .163 38. .794 13. .231 1. .00 41. .60 ISG 714
ATOM 714 CB TRP 93 155. ,184 38. .470 11. ,727 1. .00 41. .60 ISG 715
ATOM 715 CG TRP 93 155. .480 39. .690 10. .891 1, .00 41, .60 ISG 716
ATOM 716 CD2 TRP 93 156. .794 40. .232 10. .688 1, .00 41. .60 ISG 717
ATOM 717 CDl TRP 93 154. .615 40. .527 10. .249 1. .00 41. .60 ISG 718
ATOM 718 NE1 TRP 93 155. ,307 41. .565 9. .671 1. ,00 41. .60 ISG 719
ATOM 719 CE2 TRP 93 156. ,651 41. 395 9. .934 1. ,00 41. .60 ISG 720
ATOM 720 CE3 TRP 93 158. ,020 39. .803 11. .107 1. ,00 41. .60 ISG 721
ATOM 721 CZ2 TRP 93 157. ,736 42. 152 9. 592 1. .00 41. .60 ISG 722
ATOM 722 CZ3 TRP 93 159. .110 40. 561 10. .746 1. .00 41. .60 ISG 723
ATOM 723 CH2 TRP 93 158. 973 41. 714 10. 004 1. 00 41. .60 ISG 724
ATOM 724 C TRP 93 156. .543 39. 248 13. .596 1. .00 41. .60 ISG 725
ATOM 725 O TRP 93 156. 779 40. 438 13. 804 1. 00 41. .60 ISG 726
ATOM 726 N GLY 94 157. ,497 38. 295 13. .696 1. .00 44. .32 ISG 727
ATOM 727 CA GLY 94 158. 852 38. 657 13. 989 1. 00 44. .32 ISG 728
ATOM 728 C GLY 94 159. 722 37. 548 13. 491 1. 00 44. .32 ISG 729 ATOM 729 O GLY 94 159..387 36..374 13..639 1.00 44..32 ISG 730
ATOM 730 N PHE 95 160. .870 37. .897 12. .874 1. .00 50. ,76 ISG 731
ATOM 731 CA PHE 95 161. .766 36. .886 12. .400 1. .00 50. ,76 ISG 732
ATOM 732 CB PHE 95 161, .639 36. .551 10. .900 1. .00 50. ,76 ISG 733
ATOM 733 CG PHE 95 162, .071 37. .719 10. .084 1. ,00 50. .76 ISG 734
ATOM 734 CDl PHE 95 161, .181 38. .714 9. .759 1. ,00 50. .76 ISG 735
ATOM 735 CD2 PHE 95 163, .369 37. .813 9. .637 1. .00 50. .76 ISG 736
ATOM 736 CE1 PHE 95 161, .578 39. .790 9. .002 1. .00 50. .76 ISG 737
ATOM 737 CE2 PHE 95 163, .773 38, .886 8, .879 1. .00 50. .76 ISG 738
ATOM 738 CZ PHE 95 162, .876 39, .878 8, .561 1. .00 50. .76 ISG 739
ATOM 739 C PHE 95 163, .155 37, .367 12. .648 1. .00 50. .76 ISG 740
ATOM 740 O PHE 95 163 .407 38, .571 12. .690 1. .00 50. .76 ISG 741
ATOM 741 N GLU 96 164 , .101 36. .429 12. .861 1. .00 54. ,93 ISG 742
ATOM 742 CA GLU 96 165, .427 36. .886 13. .138 1. .00 54. .93 ISG 743
ATOM 743 CB GLU 96 165. .834 36. .690 14. .611 1. .00 54. .93 ISG 744
ATOM 744 CG GLU 96 167. .115 37. .420 15. .019 1. .00 54. .93 ISG 745
ATOM 745 CD GLU 96 167. .430 37. .042 16. .460 1. .00 54. .93 ISG 746
ATOM 746 OEl GLU 96 167, .541 35. .818 16. .735 1. .00 54. .93 ISG 747
ATOM 747 OE2 GLU 96 167. .563 37. .967 17. .305 1. .00 54. .93 ISG 748
ATOM 748 C GLU 96 166. .408 36. .112 12, .318 1. .00 54. .93 ISG 749
ATOM 749 O GLU 96 166, .389 34, .881 12, .295 1. .00 54. .93 ISG 750
ATOM 750 N SER 97 167, .273 36, .848 11, .591 1. .00 57, .92 ISG 751
ATOM 751 CA SER 97 168, .406 36, .263 10, .942 1. .00 57, .92 ISG 752
ATOM 752 CB SER 97 168, .985 37, .121 9, .805 1. .00 57, .92 ISG 753
ATOM 753 OG SER 97 169, .480 38, .347 10, .322 1. .00 57, .92 ISG 754
ATOM 754 C SER 97 169, .375 36, .265 12, .067 1. .00 57, .92 ISG 755
ATOM 755 O SER 97 168, .984 36, .740 13, .128 1. .00 57, .92 ISG 756
ATOM 756 N PRO 98 170, .578 35, .783 11, .971 1. .00 57, .08 ISG 757
ATOM 757 CA PRO 98 171 .401 35, .780 13, .145 1. .00 57, .08 ISG 758
ATOM 758 CD PRO 98 170 .951 34, .741 11, .031 1. .00 57, .08 ISG 759
ATOM 759 CB PRO 98 172 .677 35, .052 12, .740 1. .00 57, .08 ISG 760
ATOM 760 CG PRO 98 172 .183 34, .061 11 .663 1. .00 57, .08 ISG 761
ATOM 761 C PRO 98 171 .574 37, .119 13 .790 1. .00 57, .08 ISG 762
ATOM 762 O PRO 98 171 .171 37 .265 14 .942 1. .00 57, .08 ISG 763
ATOM 763 N LEU 99 172 .104 38 .107 13 .053 1. .00 50, .62 ISG 764
ATOM 764 CA LEU 99 172 .308 39 .428 13 .566 1. .00 50, .62 ISG 765
ATOM 765 CB LEU 99 173 .281 40 .248 12 .702 1. .00 50, .62 ISG 766
ATOM 766 CG LEU 99 174 .707 39 .669 12 .665 1. .00 50, .62 ISG 767
ATOM 767 CD2 LEU 99 175 .693 40 .651 12 .012 1. .00 50, .62 ISG 768
ATOM 768 CDl LEU 99 174 .729 38 .278 12 .010 1. .00 50, .62 ISG 769
ATOM 769 C LEU 99 171 .040 40 .217 13 .668 1. .00 50, .62 ISG 770
ATOM 770 O LEU 99 170 .852 40 .975 14 .619 1, .00 50, .62 ISG 771
ATOM 771 N PHE 100 170 .123 40 .080 12 .691 1. .00 44 , .95 ISG 772
ATOM 772 CA PHE 100 169 .089 41 .074 12 .670 1. .00 44 , .95 ISG 773
ATOM 773 CB PHE 100 168 .887 41 .662 11 .263 1. .00 44, .95 ISG 774
ATOM 774 CG PHE 100 168 .196 42 .974 11 .397 1. .00 44, .95 ISG 775
ATOM 775 CDl PHE 100 166 .826 43 .062 11 .478 1. .00 44, .95 ISG 776
ATOM 776 CD2 PHE 100 168 .941 44 .130 11 .440 1. .00 44, .95 ISG 777
ATOM 777 CE1 PHE 100 166 .219 4 .290 11 .601 1. .00 44, .95 ISG 778
ATOM 778 CE2 PHE 100 168 .338 45 .359 11 .562 1, .00 44. .95 ISG 779
ATOM 779 CZ PHE 100 166 .969 45 .440 11 .643 1. .00 44, .95 ISG 780
ATOM 780 C PHE 100 167 .772 40 .557 13 .148 1. .00 44, .95 ISG 781
ATOM 781 O PHE 100 167 .410 39 .398 12 .943 1. .00 44, .95 ISG 782
ATOM 782 N GLN 101 167 .017 41 .452 13 .823 1. .00 37, .09 ISG 783
ATOM 783 CA GLN 101 165 .706 41 .121 14 .308 1. .00 37. .09 ISG 784
ATOM 784 CB GLN 101 165 .550 41 .316 15 .826 1. .00 37, .09 ISG 785
ATOM 785 CG GLN 101 166 .432 40 .381 16 .653 1. .00 37. .09 ISG 786 ATOM 786 CD GLN 101 166..183 40,.676 18..125 1..00 37..09 ISG 787
ATOM 787 OEl GLN 101 165. .393 41. .553 18. .471 1. .00 37. .09 ISG 788
ATOM 788 NE2 GLN 101 166, .871 39. .918 19. .021 1. .00 37. .09 ISG 789
ATOM 789 C GLN 101 164, .737 42, .046 13, .639 1. .00 37. .09 ISG 790
ATOM 790 O GLN 101 164 , .856 43. .266 13. .748 1. ,00 37. .09 ISG 791
ATOM 791 N ASP 102 163, .744 41. .479 12. .923 1. .00 31. .56 ISG 792
ATOM 792 CA ASP 102 162, .771 42, .286 12. .240 1. .00 31. .56 ISG 793
ATOM 793 CB ASP 102 162, .653 41. .962 10. .740 1. .00 31. .56 ISG 794
ATOM 794 CG ASP 102 163, .846 42, .574 10. .021 1. .00 31. .56 ISG 795
ATOM 795 ODl ASP 102 163. .985 43. .824 10. .080 1. .00 31. .56 ISG 796
ATOM 796 OD2 ASP 102 164. .636 41. .805 9. .410 1. .00 31. .56 ISG 797
ATOM 797 C ASP 102 161, .429 42. .036 12. .850 1. .00 31. .56 ISG 798
ATOM 798 O ASP 102 161, .096 40. .911 13. .221 1, .00 31. ,56 ISG 799
ATOM 799 N THR 103 160, .624 43. .108 12 , .984 1, .00 28. .59 ISG 800
ATOM 800 CA THR 103 159 .312 42. .973 13, .547 1, .00 28. .59 ISG 801
ATOM 801 CB THR 103 159, .222 43, .430 14. .973 1, .00 28. .59 ISG 802
ATOM 802 OGl THR 103 157, .951 43, .099 15. .515 1. .00 28. .59 ISG 803
ATOM 803 CG2 THR 103 159 .442 44 .951 15. .020 1. .00 28. .59 ISG 804
ATOM 804 C THR 103 158, .377 43, .829 12. .753 1. .00 28. .59 ISG 805
ATOM 805 O THR 103 158 .801 44, .728 12, .027 1, .00 28. .59 ISG 806
ATOM 806 N GLY 104 157 .061 43 .557 12 .864 1. .00 27. .22 ISG 807
ATOM 807 CA GLY 104 156, .105 44, .364 12, .163 1. .00 27. .22 ISG 808
ATOM 808 C GLY 104 154 .785 43 .664 12, .193 1, .00 27. .22 ISG 809
ATOM 809 O GLY 104 154, .708 42, .458 12, .423 1. .00 27. .22 ISG 810
ATOM 810 N GLY 105 153, .699 44 .427 11, .956 1. .00 29. .87 ISG 811
ATOM 811 CA GLY 105 152 .384 43 .855 11, .943 1, .00 29, .87 ISG 812
ATOM 812 C GLY 105 152, .127 43, .340 10, .564 1. .00 29. .87 ISG 813
ATOM 813 O GLY 105 152 .874 43 .634 9, .631 1. .00 29, .87 ISG 814
ATOM 814 N ALA 106 151 .045 42 .553 10 .398 1, .00 35, .26 ISG 815
ATOM 815 CA ALA 106 150, .725 42, .048 9, .094 1. .00 35. .26 ISG 816
ATOM 816 CB ALA 106 151, .332 40 .665 8, .800 1. .00 35. .26 ISG 817
ATOM 817 C ALA 106 149 .239 41 .907 9 .005 1, .00 35. .26 ISG 818
ATOM 818 O ALA 106 148, .554 41, .814 10, .021 1. .00 35. .26 ISG 819
ATOM 819 N ASP 107 148 .688 41 .919 7, .774 1. .00 41. .92 ISG 820
ATOM 820 CA ASP 107 147 .273 41 .735 7 .639 1, .00 41, .92 ISG 821
ATOM 821 CB ASP 107 146, .494 42, .981 7, .174 1, .00 41. .92 ISG 822
ATOM 822 CG ASP 107 147 .078 43 .457 5, .862 1, .00 41, .92 ISG 823
ATOM 823 ODl ASP 107 148 .316 43 .675 5 .834 1, .00 41, .92 ISG 824
ATOM 824 OD2 ASP 107 146, .306 43, .610 4, .878 1, .00 41. .92 ISG 825
ATOM 825 C ASP 107 147 .013 40 .592 6, .713 1, .00 41. .92 ISG 826
ATOM 826 O ASP 107 147, .741 40, .376 5, .743 1. .00 41. .92 ISG 827
ATOM 827 N LEU 108 145, .967 39. .805 7, .037 1. .00 45. .92 ISG 828
ATOM 828 CA LEU 108 145 .593 38 .642 6, .285 1. .00 45. .92 ISG 829
ATOM 829 CB LEU 108 145, .557 37. .364 7, .134 1. .00 45. .92 ISG 830
ATOM 830 CG LEU 108 145, .149 36. .113 6, .337 1. .00 45. .92 ISG 831
ATOM 831 CD2 LEU 108 144 .550 35 .024 7, .234 1, .00 45. .92 ISG 832
ATOM 832 CDl LEU 108 146, .297 35. .623 5, .446 1. .00 45. .92 ISG 833
ATOM 833 C LEU 108 144, .184 38, .846 5, .822 1. .00 45. .92 ISG 834
ATOM 834 O LEU 108 143 .390 39 .511 6, .488 1. .00 45. .92 ISG 835
ATOM 835 N PHE 109 143 , .842 38, .278 4 , .649 1. .00 45. ,89 ISG 836
ATOM 836 CA PHE 109 142. .511 38, .400 4. .140 1. .00 45. .89 ISG 837
ATOM 837 CB PHE 109 142 .469 39 .295 2 .887 1. .00 45. .89 ISG 838
ATOM 838 CG PHE 109 141, .056 39, .555 2 , .498 1. .00 45. ,89 ISG 839
ATOM 839 CDl PHE 109 140, .357 38, .649 1, .738 1. .00 45. .89 ISG 840
ATOM 840 CD2 PHE 109 140 .436 40, .720 2, .887 1. .00 45. .89 ISG 841
ATOM 841 CE1 PHE 109 139, .054 38, .901 1, .379 1. .00 45. .89 ISG 842
ATOM 842 CE2 PHE 109 139, .133 40, .977 2 , .531 1. .00 45. ,89 ISG 843 5 > H >H >H, > > > > >
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ATOM 900 O THR 116 127..865 23..243 6..564 1..00 35..95 ISG 901
ATOM 901 N GLY 117 125. .673 23, .731 6, .340 1. .00 32. .31 ISG 902
ATOM 902 CA GLY 117 125. .332 22, .959 7, .498 1. .00 32. .31 ISG 903
ATOM 903 C GLY 117 123, .966 22 .389 7. .284 1. .00 32. .31 ISG 904
ATOM 904 O GLY 117 123, .119 22. .997 6, .633 1. .00 32. .31 ISG 905
ATOM 905 N ILE 118 123, .711 21. .197 7 .857 1, .00 29. .72 ISG 906
ATOM 906 CA ILE 118 122, .433 20. .573 7. .680 1. .00 29. .72 ISG 907
ATOM 907 CB ILE 118 122 .520 19 .149 7 .213 1. .00 29, .72 ISG 908
ATOM 908 CG2 ILE 118 121, .100 18. .559 7, .233 1, .00 29. .72 ISG 909
ATOM 909 CGI ILE 118 123, .193 19 .081 5 .832 1. .00 29, .72 ISG 910
ATOM 910 CDl ILE 118 122, .436 19, .848 4, .748 1. .00 29. .72 ISG 911
ATOM 911 C ILE 118 121, .743 20 .566 9 .004 1. .00 29. .72 ISG 912
ATOM 912 O ILE 118 122. .332 20, .227 10. .029 1. .00 29. .72 ISG 913
ATOM 913 N ILE 119 120. .455 20, .963 9 .005 1, .00 27, .87 ISG 914
ATOM 914 CA ILE 119 119, .701 21. .015 10, .223 1. .00 27. .87 ISG 915
ATOM 915 CB ILE 119 118, .976 22, .315 10, .417 1. .00 27, .87 ISG 916
ATOM 916 CG2 ILE 119 118, .080 22, .177 11, .659 1. .00 27. .87 ISG 917
ATOM 917 CGI ILE 119 119 .974 23, .481 10 .500 1. .00 27. .87 ISG 918
ATOM 918 CDl ILE 119 119, .315 24, .855 10, .398 1, .00 27. .87 ISG 919
ATOM 919 C ILE 119 118, .664 19, .940 10, .163 1. .00 27. .87 ISG 920
ATOM 920 O ILE 119 117, .894 19, .851 9, .207 1, .00 27. .87 ISG 921
ATOM 921 N ILE 120 118 .622 19 .086 11 .204 1. .00 28, .92 ISG 922
ATOM 922 CA ILE 120 117, .667 18, .017 11. .236 1. .00 28, .92 ISG 923
ATOM 923 CB ILE 120 118 .267 16 .679 11. .562 1. .00 28, .92 ISG 924
ATOM 924 CG2 ILE 120 118, .838 16, .735 12. .988 1, .00 28, .92 ISG 925
ATOM 925 CGI ILE 120 117 .236 15 .561 11, .342 1. .00 28, .92 ISG 926
ATOM 926 CDl ILE 120 117, .842 14, .158 11, .357 1. .00 28, .92 ISG 927
ATOM 927 C ILE 120 116 .671 18, .341 12, .296 1. .00 28, .92 ISG 928
ATOM 928 O ILE 120 117, .024 18, .751 13, .402 1. .00 28, .92 ISG 929
ATOM 929 N LEU 121 115 .372 18, .186 11, .964 1. .00 31, .00 ISG 930
ATOM 930 CA LEU 121 114, .331 18, .509 12, .893 1. .00 31, .00 ISG 931
ATOM 931 CB LEU 121 113 .164 19, .270 12, .240 1. .00 31, .00 ISG 932
ATOM 932 CG LEU 121 113, .563 20, .645 11, .677 1. .00 31. .00 ISG 933
ATOM 933 CD2 LEU 121 114 .259 21, .506 12, .745 1, .00 31. .00 ISG 934
ATOM 934 CDl LEU 121 112, .359 21, .357 11, .043 1. .00 31, .00 ISG 935
ATOM 935 C LEU 121 113 .769 17, .232 13, .430 1. .00 31. .00 ISG 936
ATOM 936 O LEU 121 113. .542 16, .278 12 , .688 1. .00 31. .00 ISG 937
ATOM 937 N THR 122 113 .540 17, .185 14, .755 1, .00 33. .00 ISG 938
ATOM 938 CA THR 122 112, .992 16, .002 15. .350 1. .00 33. .00 ISG 939
ATOM 939 CB THR 122 114 .025 15, .104 15, .965 1. .00 33, .00 ISG 940
ATOM 940 OGl THR 122 114, .693 15. .773 17. .023 1. .00 33. .00 ISG 941
ATOM 941 CG2 THR 122 115 .030 14. .696 14. .875 1, .00 33. .00 ISG 942
ATOM 942 C THR 122 112, .061 16. .424 16. .437 1. .00 33. .00 ISG 943
ATOM 943 O THR 122 111, .845 17, .613 16. .669 1. .00 33. .00 ISG 944
ATOM 944 N ARG 123 111, .460 15. .433 17. .117 1. .00 35. .35 ISG 945
ATOM 945 CA ARG 123 110, .535 15, .702 18. .177 1. .00 35. .35 ISG 946
ATOM 946 CB ARG 123 109, .084 15. ,349 17. .814 1. .00 35. ,35 ISG 947
ATOM 947 CG ARG 123 108. .156 15. .269 19. .027 1. .00 35. .35 ISG 948
ATOM 948 CD ARG 123 106, .799 14. .636 18. .713 1. .00 35. ,35 ISG 949
ATOM 949 NE ARG 123 106, .139 14. .327 20. .012 1. .00 35. .35 ISG 950
ATOM 950 CZ ARG 123 106 .353 13. .116 20. .606 1. .00 35. .35 ISG 951
ATOM 951 NHl ARG 123 107, .161 12. .195 20. ,004 1. .00 35. ,35 ISG 952
ATOM 952 NH2 ARG 123 105 .761 12, .825 21. .801 1. .00 35. .35 ISG 953
ATOM 953 C ARG 123 110, .894 14. .830 19. .329 _ 1. .00 35. ,35 ISG 954
ATOM 954 O ARG 123 111, .444 13 , .743 19. .157 ' 1. .00 35. .35 ISG 955
ATOM 955 N ASN 124 110, .595 15. .303 20. .552 1. ,00 36. ,16 ISG 956
ATOM 956 CA ASN 124 110, .817 14. .474 21. .693 1. .00 36. .16 ISG 957 ATOM 957 CB ASN 124 111..883 15.,003 22..681 1..00 36..16 ISG 958
ATOM 958 CG ASN 124 111. .486 16. .355 23. ,251 1. .00 36. .16 ISG 959
ATOM 959 ODl ASN 124 110. .347 16. ,793 23. ,121 1. .00 36. .16 ISG 960
ATOM 960 ND2 ASN 124 112, .460 17. .045 23. .902 1. .00 36. .16 ISG 961
ATOM 961 C ASN 124 109, .485 14. .312 22. .356 1. .00 36. .16 ISG 962
ATOM 962 O ASN 124 108. .602 15. .155 22. .222 1. .00 36. .16 ISG 963
ATOM 963 N ASP 125 109, .313 13. .206 23. .092 1. .00 36. .08 ISG 964
ATOM 964 CA ASP 125 108, .072 12. .848 23. .714 1. .00 36. .08 ISG 965
ATOM 965 CB ASP 125 108, .167 11, .532 24, .503 1. .00 36, .08 ISG 966
ATOM 966 CG ASP 125 108, .353 10, .392 23, .510 1. .00 36, .08 ISG 967
ATOM 967 ODl ASP 125 108, .206 10, .644 22. .284 1. .00 36, .08 ISG 968
ATOM 968 OD2 ASP 125 108, .640 9. .253 23. .966 1. .00 36. .08 ISG 969
ATOM 969 C ASP 125 107, .690 13. .918 24. .686 1. .00 36. .08 ISG 970
ATOM 970 O ASP 125 106, .508 14. .093 24. .978 1. .00 36. .08 ISG 971
ATOM 971 N PHE 126 108 .679 14, .666 25, .211 1. .00 37, .38 ISG 972
ATOM 972 CA PHE 126 108, .409 15, .712 26, .157 1. .00 37, .38 ISG 973
ATOM 973 CB PHE 126 109 .655 16, .523 26, .549 1. .00 37, .38 ISG 974
ATOM 974 CG PHE 126 109, .315 17, .279 27. .788 1. .00 37, .38 ISG 975
ATOM 975 CDl PHE 126 109, .481 16, .687 29, .020 1. .00 37, .38 ISG 976
ATOM 976 CD2 PHE 126 108, .829 18. .564 27, .731 1. .00 37, .38 ISG 977
ATOM 977 CE1 PHE 126 109 .173 17 .364 30, .176 1. .00 37 .38 ISG 978
ATOM 978 CE2 PHE 126 108 .520 19. .248 28, .883 1. .00 37 .38 ISG 979
ATOM 979 CZ PHE 126 108 .692 18. .649 30, .109 1, .00 37, .38 ISG 980
ATOM 980 C PHE 126 107. .466 16. .622 25. .443 1. .00 37, .38 ISG 981
ATOM 981 O PHE 126 106, .615 17. .272 26. .050 1. .00 37, .38 ISG 982
ATOM 982 N GLY 127 107 .606 16 .684 24, .107 1, .00 38 .77 ISG 983
ATOM 983 CA GLY 127 106 .690 17, .463 23, .332 1, .00 38 .77 ISG 984
ATOM 984 C GLY 127 107 .400 18, .640 22 .758 1, .00 38 .77 ISG 985
ATOM 985 O GLY 127 106 .808 19, .415 22 , .008 1. .00 38, .77 ISG 986
ATOM 986 N HIS 128 108 .689 18, .805 23, .100 1, .00 42, .73 ISG 987
ATOM 987 CA HIS 128 109 .465 19. .884 22 , .565 1. .00 42, .73 ISG 988
ATOM 988 NDl HIS 128 109 .841 22 .387 24, .743 1. .00 42 .73 ISG 989
ATOM 989 CG HIS 128 110 .210 21. .061 24, .710 1, .00 42 .73 ISG 990
ATOM 990 CB HIS 128 110 .630 20, .340 23, .464 1. .00 42 .73 ISG 991
ATOM 991 NE2 HIS 128 109 .715 21, .642 26, .834 1. .00 42 .73 ISG 992
ATOM 992 CD2 HIS 128 110 .126 20, .621 25, .995 1, .00 42, .73 ISG 993
ATOM 993 CE1 HIS 128 109 .556 22, .682 26, .036 1. .00 42, .73 ISG 994
ATOM 994 C HIS 128 110 .080 19 .439 21, .275 1. .00 42 .73 ISG 995
ATOM 995 O HIS 128 110 .359 18 .262 21, .051 1, .00 42 .73 ISG 996
ATOM 996 N PRO 129 110 .260 20, .397 20, .409 1. .00 46, .23 ISG 997
ATOM 997 CA PRO 129 110 .884 20, .129 19. .142 1. .00 46, .23 ISG 998
ATOM 998 CD PRO 129 109 .310 21, .495 20, .326 1. .00 46, .23 ISG 999
ATOM 999 CB PRO 129 110 .531 21 .308 18, .239 1. .00 46 .23 1SG1000
ATOM 1000 CG PRO 129 109 .220 21 .848 18, .834 1, .00 46, .23 1SG1001
ATOM 1001 C PRO 129 112 .355 19, .983 19, .349 1. .00 46, .23 1SG1002
ATOM 1002 O PRO 129 112 .866 20, .474 20, .355 1. .00 46, .23 1SG1003
ATOM 1003 N THR 130 113, .059 19, .307 18, .423 1. .00 47, .88 1SG1004
ATOM 1004 CA THR 130 114, .473 19, .173 18. .595 1. .00 47. .88 1SG1005
ATOM 1005 CB THR 130 114 .898 17 .778 18. .946 1, .00 47. .88 1SG1006
ATOM 1006 OGl THR 130 114 .247 17 .345 20. .130 1. .00 47, .88 1SG1007
ATOM 1007 CG2 THR 130 116 .414 17 .781 19, .171 1. .00 47, .88 1SG1008
ATOM 1008 C THR 130 115, .124 19, .521 17, .295 1. .00 47. .88 1SG1009
ATOM 1009 O THR 130 114, .566 19, .279 16, .227 1. .00 47. .88 1SG1010
ATOM 1010 N LEU 131 116, .324 20, .133 17. .362 1. .00 48. .13 1SG1011
ATOM 1011 CA LEU 131 117 .057 20 .472 16. .176 1. .00 48, .13 1SG1012
ATOM 1012 CB LEU 131 116 .942 21, .954 15. .774 1. .00 48. .13 1SG1013
ATOM 1013 CG LEU 131 115 .512 22, .397 15. .411 1. .00 48. .13 1SG1014 ATOM 1014 CD2 LEU 131 115.,512 23..773 14..726 1..00 48..13 1SG1015
ATOM 1015 CDl LEU 131 114. .578 22. .342 16. .631 1. .00 48. .13 1SG1016
ATOM 1016 C LEU 131 118. .504 20. .219 16. .470 1. .00 48. .13 1SG1017
ATOM 1017 O LEU 131 118. .992 20. .552 17. .549 1. .00 48. .13 1SG1018
ATOM 1018 N LYS 132 119. .233 19, .605 15. .518 1. .00 45. .31 1SG1019
ATOM 1019 CA LYS 132 120. .634 19. .368 15. .729 1. .00 45, .31 1SG1020
ATOM 1020 CB LYS 132 120. .948 17, .955 16. .250 1. .00 45, .31 1SG1021
ATOM 1021 CG LYS 132 120. .414 17, .693 17. .660 1. .00 45, .31 1SG1022
ATOM 1022 CD LYS 132 120. .442 16, .217 18. .062 1. .00 45, .31 1SG1023
ATOM 1023 CE LYS 132 119. .910 15, .957 19. .472 1. .00 45, .31 1SG1024
ATOM 1024 NZ LYS 132 119, .973 14, .511 19. .780 1, .00 45, .31 1SG1025
ATOM 1025 C LYS 132 121. .300 19, .504 14. .400 1. .00 45, .31 1SG1026
ATOM 1026 O LYS 132 120. .647 19. .374 13. .366 1. .00 45, .31 1SG1027
ATOM 1027 N LEU 133 122. .620 19. .791 14 , .370 1. .00 45, .40 1SG1028
ATOM 1028 CA LEU 133 123. .189 19, .859 13. .057 1. .00 45, .40 1SG1029
ATOM 1029 CB LEU 133 124. .020 21, .119 12. .718 1. .00 45, .40 1SG1030
ATOM 1030 CG LEU 133 125. .305 21, .405 13, .509 1, .00 45, .40 1SG1031
ATOM 1031 CD2 LEU 133 125. .755 22, .844 13 , .218 1, .00 45 .40 1SG1032
ATOM 1032 CDl LEU 133 126. .422 20. .388 13, .226 1, .00 45 .40 1SG1033
ATOM 1033 C LEU 133 123. .941 18, .599 12, .781 1. .00 45 .40 1SG1034
ATOM 1034 O LEU 133 124. .826 18, .189 13, .530 1. .00 45 .40 1SG1035
ATOM 1035 N GLN 134 123. .511 17 .910 11, .705 1. .00 44 .15 1SG1036
ATOM 1036 CA GLN 134 124. .067 16 .658 11, .293 1. .00 44 .15 1SG1037
ATOM 1037 CB GLN 134 123. .231 15, .964 10, .202 1. .00 44 .15 1SG1038
ATOM 1038 CG GLN 134 121. .791 15 .643 10 .609 1 .00 44 .15 1SG1039
ATOM 1039 CD GLN 134 120. .917 16 .847 10 .278 1 .00 44 .15 1SG1040
ATOM 1040 OEl GLN 134 121. .024 17, .911 10, .885 1. .00 44, .15 1SG1041
ATOM 1041 NE2 GLN 134 120, .013 16, .672 9, .278 1, .00 44, .15 1SG1042
ATOM 1042 C GLN 134 125, .435 16 .839 10, .711 1, .00 44 .15 1SG1043
ATOM 1043 O GLN 134 126. .358 16, .102 11, .054 1. .00 44 .15 1SG1044
ATOM 1044 N ASP 135 125, .602 17, .825 9, .804 1. .00 43 .49 1SG1045
ATOM 1045 CA ASP 135 126, .872 17, .946 9, .144 1, .00 43 .49 1SG1046
ATOM 1046 CB ASP 135 126, .899 17 .257 7, .768 1. .00 43 .49 1SG1047
ATOM 1047 CG ASP 135 128, .341 17 .176 7, .285 1, .00 43 .49 1SG1048
ATOM 1048 ODl ASP 135 129, .263 17 .313 8, .132 1, .00 43 .49 1SG1049
ATOM 1049 OD2 ASP 135 128, .539 16 .965 6, .059 1. .00 43 .49 1SG1050
ATOM 1050 C ASP 135 127, .189 19 .390 8 .915 1. .00 43 .49 1SG1051
ATOM 1051 O ASP 135 126, .295 20 .229 8, .806 1, .00 43 .49 1SG1052
ATOM 1052 N CYS 136 128, .498 19 .711 8 .850 1. .00 43 .63 1SG1053
ATOM 1053 CA CYS 136 128, .934 21 .054 8 .611 1. .00 43 .63 1SG1054
ATOM 1054 CB CYS 136 129, .256 21 .804 9 .910 1, .00 43 .63 1SG1055
ATOM 1055 SG CYS 136 129. .996 23, .432 9, .624 1. .00 43, .63 1SG1056
ATOM 1056 C CYS 136 130. .193 20, .998 7, .804 1. .00 43, .63 1SG1057
ATOM 1057 O CYS 136 130. .996 20, .078 7. .951 1. .00 43, .63 1SG1058
ATOM 1058 N TYR 137 130. .374 21, .974 6, .890 1. .00 41. .26 1SG1059
ATOM 1059 CA TYR 137 131, .569 22, .025 6, .099 1. .00 41, .26 1SG1060
ATOM 1060 CB TYR 137 131. .420 21, .281 4, .760 1. .00 41, .26 1SG1061
ATOM 1061 CG TYR 137 132. .697 21, .383 4, .000 1. .00 41, .26 1SG1062
ATOM 1062 CDl TYR 137 133. .791 20, .627 4, .354 1. .00 41, .26 1SG1063
ATOM 1063 CD2 TYR 137 132. .793 22 .225 2, .916 1. .00 41, .26 1SG1064
ATOM 1064 CE1 TYR 137 134, .966 20, .722 3, .646 1. .00 41, .26 1SG1065
ATOM 1065 CE2 TYR 137 133, .965 22, .324 2, .203 1, .00 41, .26 1SG1066
ATOM 1066 CZ TYR 137 135, .055 21, .571 2, .569 1. .00 41, .26 1SG1067
ATOM 1067 OH TYR 137 136. .259 21, .671 1. .841 1. .00 41, .26 1SG1068
ATOM 1068 C TYR 137 131. .863 23 .463 5, .800 1. .00 41, .26 1SG1069
ATOM 1069 O TYR 137 130. .960 24 .240 5, .496 1. .00 41, .26 1SG1070
ATOM 1070 N ALA 138 133. ,151 23. .855 5. .861 1. .00 39. .61 1SG1071
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ATOM 1299 CDl LEU 167 142..079 26..704 3.,000 1..00 36..08 1SG1300
ATOM 1300 C LEU 167 142. ,186 26. .114 7. .483 1. .00 36. .08 1SG1301
ATOM 1301 O LEU 167 140. .981 26. .165 7. .726 1. .00 36. ,08 1SG1302
ATOM 1302 N LYS 168 142. .929 25. .030 7. .770 1. .00 34. .56 1SG1303
ATOM 1303 CA LYS 168 142. .309 23. .858 8. ,321 1. .00 34. .56 1SG1304
ATOM 1304 CB LYS 168 143. .279 22. .665 8. ,447 1. .00 34. .56 1SG1305
ATOM 1305 CG LYS 168 144. .399 22. .819 9. .480 1. .00 34. .56 1SG1306
ATOM 1306 CD LYS 168 143. .953 22. .600 10. .928 1. .00 34. .56 1SG1307
ATOM 1307 CE LYS 168 145. .083 22. .757 11. .947 1. .00 34. .56 1SG1308
ATOM 1308 NZ LYS 168 144, .566 22 , .529 13 .315 1. .00 34. .56 1SG1309
ATOM 1309 C LYS 168 141, .733 24. .178 9. .664 1. .00 34. .56 1SG1310
ATOM 1310 O LYS 168 140, .632 23. .737 9, .988 1. .00 34. .56 1SG1311
ATOM 1311 N ASN 169 142. .465 24. .954 10. .485 1. .00 34. .15 1SG1312
ATOM 1312 CA ASN 169 142, .011 25, .283 11. .807 1. .00 34. .15 1SG1313
ATOM 1313 CB ASN 169 143, .070 26. .046 12. .623 1. .00 34. .15 1SG1314
ATOM 1314 CG ASN 169 142, .637 26. .054 14. .083 1. .00 34. .15 1SG1315
ATOM 1315 ODl ASN 169 141, .486 26, .342 14 .408 1, .00 34, .15 1SG1316
ATOM 1316 ND2 ASN 169 143, .588 25, .719 14 .996 1, .00 34, .15 1SG1317
ATOM 1317 C ASN 169 140, .801 26. .156 11. .705 1. .00 34, .15 1SG1318
ATOM 1318 O ASN 169 139, .859 26. .020 12 .483 1. .00 34, .15 1SG1319
ATOM 1319 N LEU 170 140, .809 27, .092 10 .739 1. .00 36, .48 1SG1320
ATOM 1320 CA LEU 170 139, .727 28, .015 10 .548 1. .00 36, .48 1SG1321
ATOM 1321 CB LEU 170 140, .021 29 .002 9 .403 1. .00 36, .48 1SG1322
ATOM 1322 CG LEU 170 138, .873 29, .977 9 .081 1, .00' 36. .48 1SG1323
ATOM 1323 CD2 LEU 170 139, .127 30, .711 7 .755 1, .00 36. .48 1SG1324
ATOM 1324 CDl LEU 170 138, .599 30, .937 10. .247 1. .00 36. .48 1SG1325
ATOM 1325 C LEU 170 138 .499 27, .255 10 .171 1. .00 36 .48 1SG1326
ATOM 1326 O LEU 170 137, .402 27, .532 10 .651 1. .00 36. .48 1SG1327
ATOM 1327 N ASN 171 138, .663 26, .261 9 .290 1, .00 39, .60 1SG1328
ATOM 1328 CA ASN 171 137 .561 25, .491 8 .805 1 .00 39 .60 1SG1329
ATOM 1329 CB ASN 171 138 .053 24, .435 7 .805 1. .00 39 .60 1SG1330
ATOM 1330 CG ASN 171 136, .898 24, .002 6 .929 1. .00 39, .60 1SG1331
ATOM 1331 ODl ASN 171 135 .779 23 .807 7 .398 1 .00 39 .60 1SG1332
ATOM 1332 ND2 ASN 171 137 .179 23 .856 5 .606 1, .00 39 .60 1SG1333
ATOM 1333 C ASN 171 136, .954 24, .783 9 .970 1, .00 39, .60 1SG1334
ATOM 1334 O ASN 171 135 .733 24 .685 10 .082 1 .00 39 .60 1SG1335
ATOM 1335 N GLU 172 137 .822 24 .248 10 .850 1 .00 43 .44 1SG1336
ATOM 1336 CA GLU 172 137 .419 23, .532 12 .021 1, .00 43, .44 1SG1337
ATOM 1337 CB GLU 172 138 .594 22 .824 12 .716 1, .00 43, .44 1SG1338
ATOM 1338 CG GLU 172 138 .178 22 .022 13 .950 1 .00 43, .44 1SG1339
ATOM 1339 CD GLU 172 139 .427 21, .379 14 .534 1, .00 43, .44 1SG1340
ATOM 1340 OEl GLU 172 140 .530 21, .613 13 .971 1, .00 43, .44 1SG1341
ATOM 1341 OE2 GLU 172 139 .296 20, .645 15 .550 1 .00 43, .44 1SG1342
ATOM 1342 C GLU 172 136 .811 24, .465 13 .021 1, .00 43. .44 1SG1343
ATOM 1343 O GLU 172 135 .845 24, .121 13 .680 1, .00 43. .44 1SG1344
ATOM 1344 N MET 173 137 .343 25 .674 13 .213 1 .00 48. .76 1SG1345
ATOM 1345 CA MET 173 136 .740 26, .485 14 .231 1, .00 48. .76 1SG1346
ATOM 1346 CB MET 173 137 .507 27, .799 14 .458 1. .00 48. .76 1SG1347
ATOM 1347 CG MET 173 138 .877 27 .584 15 .107 1 .00 48. .76 1SG1348
ATOM 1348 SD MET 173 139 .931 29, .061 15 .199 1 .00 48, .76 1SG1349
ATOM 1349 CE MET 173 140, .677 28, .824 13 .559 1, .00 48, .76 1SG1350
ATOM 1350 C MET 173 135 .332 26 .821 13 .851 1 .00 48, .76 1SG1351
ATOM 1351 0 MET 173 134 .422 26, .731 14 .672 1 .00 48, .76 1SG1352
ATOM 1352 N LEU 174 135, .103 27, .191 12 .579 1, .00 51. .71 1SG1353
ATOM 1353 CA LEU 174 133, .790 27. .606 12, .184 1, .00 51. .71 1SG1354
ATOM 1354 CB LEU 174 133 .702 28, .096 10 .727 1, .00 51. .71 1SG1355
ATOM 1355 CG LEU 174 134, .238 29, .528 10, .516 1. .00 51, .71 1SG1356 ATOM 1356 CD2 LEU 174 133..963 30..015 9..085 1.,00 51..71 1SG1357
ATOM 1357 CDl LEU 174 135. .712 29, .668 10. .918 1. .00 51, .71 1SG1358
ATOM 1358 C LEU 174 132. .778 26, .514 12. .374 1. .00 51. .71 1SG1359
ATOM 1359 O LEU 174 131. ,717 26. .765 12. .941 1. .00 51. .71 1SG1360
ATOM 1360 N CYS 175 133. .060 25, .274 11, .928 1. .00 54, .04 1SG1361
ATOM 1361 CA CYS 175 132. .056 24. .252 12 , .057 1. .00 54. .04 1SG1362
ATOM 1362 CB CYS 175 132. .394 22. .941 11, .323 1. .00 54, .04 1SG1363
ATOM 1363 SG CYS 175 131. .984 23. .029 9, .559 1. .00 54, .04 1SG1364
ATOM 1364 C CYS 175 131. .746 23. .969 13, .499 1. .00 54, .04 1SG1365
ATOM 1365 O CYS 175 130. .575 23, .861 13, .846 1. .00 54, .04 1SG1366
ATOM 1366 N PRO 176 132. .706 23, .786 14 , .357 1. .00 52. .46 1SG1367
ATOM 1367 CA PRO 176 132. .319 23, .701 15, .731 1, .00 52. .46 1SG1368
ATOM 1368 CD PRO 176 133. .562 22, .641 14, .087 1. .00 52. .46 1SG1369
ATOM 1369 CB PRO 176 133, .542 23 .179 16 .467 1, .00 52. .46 1SG1370
ATOM 1370 CG PRO 176 134. .064 22. .140 15, .458 1, .00 52. .46 1SG1371
ATOM 1371 C PRO 176 131. .590 24. .860 16, .330 1. .00 52. .46 1SG1372
ATOM 1372 O PRO 176 130. .767 24. .612 17, .208 1. .00 52, .46 1SG1373
ATOM 1373 N ILE 177 131. .837 26. .115 15, .916 1. .00 46, .70 1SG1374
ATOM 1374 CA ILE 177 131. .006 27 .141 16 .477 1. .00 46 .70 1SG1375
ATOM 1375 CB ILE 177 131. .395 28, .539 16, .086 1, .00 46, .70 1SG1376
ATOM 1376 CG2 ILE 177 130, .124 29, .401 16 .144 1. .00 46, .70 1SG1377
ATOM 1377 CGI ILE 177 132, .551 29, .067 16 .959 1. .00 46 .70 1SG1378
ATOM 1378 CDl ILE 177 133. .865 28, .304 16, .837 1. .00 46, .70 1SG1379
ATOM 1379 C ILE 177 129. .593 26 .922 16 .030 1. .00 46 .70 1SG1380
ATOM 1380 O ILE 177 128. .666 26, .979 16, .835 1. .00 46, .70 1SG1381
ATOM 1381 N ILE 178 129. .392 26 .639 14 .729 1, .00 41 .60 1SG1382
ATOM 1382 CA ILE 178 128. .064 26, .491 14 .201 1, .00 41, .60 1SG1383
ATOM 1383 CB ILE 178 128. .037 26, .314 12, .701 1, .00 41, .60 1SG1384
ATOM 1384 CG2 ILE 178 128, .528 24, .900 12 .353 1, .00 41 .60 1SG1385
ATOM 1385 CGI ILE 178 126, .644 26, .640 12, .128 1, .00 41, .60 1SG1386
ATOM 1386 CDl ILE 178 125, .522 25 .719 12 .602 1 .00 41 .60 1SG1387
ATOM 1387 C ILE 178 127, .373 25, .334 14 .864 1. .00 41 .60 1SG1388
ATOM 1388 O ILE 178 126, .209 25 .443 15 .244 1 .00 41 .60 1SG1389
ATOM 1389 N ALA 179 128, .068 24, .194 15 .039 1, .00 34, .16 1SG1390
ATOM 1390 CA ALA 179 127. .445 23, .036 15, .614 1, .00 34, .16 1SG1391
ATOM 1391 CB ALA 179 128, .392 21, .827 15, .689 1, .00 34 .16 1SG1392
ATOM 1392 C ALA 179 127, .008 23, .351 17, .008 1, .00 34, .16 1SG1393
ATOM 1393 O ALA 179 125, .905 22 .988 17 .414 1, .00 34 .16 1SG1394
ATOM 1394 N SER 180 127, .870 24. .041 17, .777 1, .00 29, .87 1SG1395
ATOM 1395 CA SER 180 127. .575 24, .348 19, .148 1. .00 29. .87 1SG1396
ATOM 1396 CB SER 180 128, .757 25, .012 19, .875 1. .00 29. .87 1SG1397
ATOM 1397 OG SER 180 129. .029 26, .283 19, .303 1. .00 29, .87 1SG1398
ATOM 1398 C SER 180 126. .419 25, .294 19, .221 1. .00 29, .87 1SG1399
ATOM 1399 O SER 180 125. .554 25, .165 20, .086 1. .00 29, .87 1SG1400
ATOM 1400 N GLU 181 126, .373 26 .269 18 .296 1, .00 28, .30 1SG1401
ATOM 1401 CA GLU 181 125. .355 27, .279 18, .289 1. .00 28, .30 1SG1402
ATOM 1402 CB GLU 181 125. .536 28, .294 17. .148 1. .00 28, .30 1SG1403
ATOM 1403 CG GLU 181 126. .787 29, .165 17, .287 1, .00 28, .30 1SG1404
ATOM 1404 CD GLU 181 126. .533 30, .188 18, .385 1. .00 28. .30 1SG1405
ATOM 1405 OEl GLU 181 126. .034 29 .782 19, .468 1. .00 28. .30 1SG1406
ATOM 1406 OE2 GLU 181 126. .830 31, .390 18, .152 1. .00 28. .30 1SG1407
ATOM 1407 C GLU 181 124. .030 26, .621 18, .085 1. .00 28, .30 1SG1408
ATOM 1408 O GLU 181 123. .020 27, .056 18, .635 1. .00 28, .30 1SG1409
ATOM 1409 N VAL 182 124. .000 25, .543 17. .285 1. .00 28. .07 1SG1410
ATOM 1410 CA VAL 182 122. .763 24, .880 17. .003 1. .00 28. .07 1SG1411
ATOM 1411 CB VAL 182 122. , 944 23, .650 16. .163 1. ,00 28. .07 1SG1412
ATOM 1412 CGI VAL 182 121. .582 22, .951 16. .016 1. ,00 28, .07 1SG1413 ATOM 1413 CG2 VAL 182 123.,581 24.,064 14.,825 1..00 28.,07 1SG1414
ATOM 1414 C VAL 182 122. .179 24. .458 18. ,304 1. .00 28. ,07 1SG1415
ATOM 1415 O VAL 182 120. .974 24. .573 18. .518 1. .00 28. .07 1SG1416
ATOM 1416 N LYS 183 123. .033 23. .981 19. .224 1. .00 30. ,63 1SG1417
ATOM 1417 CA LYS 183 122. .546 23. .557 20. .499 1. .00 30. .63 1SG1418
ATOM 1418 CB LYS 183 123. .672 23. ,131 21. 457 1. ,00 30. .63 1SG1419
ATOM 1419 CG LYS 183 124. ,421 21. ,876 21. ,004 1. ,00 30. .63 1SG1420
ATOM 1420 CD LYS 183 125. ,727 21. ,634 21. ,765 1. ,00 30. ,63 1SG1421
ATOM 1421 CE LYS 183 126. .475 20. .378 21. ,310 1. .00 30. ,63 1SG1422
ATOM 1422 NZ LYS 183 127. .721 20. .217 22. .091 1. .00 30. ,63 1SG1423
ATOM 1423 C LYS 183 121. .858 24. .743 21. .109 1. .00 30. .63 1SG1424
ATOM 1424 0 LYS 183 120. .810 24. .609 21. .735 1. .00 30. .63 1SG1425
ATOM 1425 N ALA 184 122. .435 25. .948 20. .930 1. .00 31. .81 1SG1426
ATOM 1426 CA ALA 184 121. .847 27. .164 21. .420 1. .00 31. .81 1SG1427
ATOM 1427 CB ALA 184 122, .702 28, .407 21. .121 1. .00 31, .81 1SG1428
ATOM 1428 C ALA 184 120, .536 27, .337 20. .724 1. .00 31, .81 1SG1429
ATOM 1429 O ALA 184 119, .556 27, .783 21. .319 1. .00 31, .81 1SG1430
ATOM 1430 N LEU 185 120. .495 26, .988 19. .425 1. .00 32. .44 1SG1431
ATOM 1431 CA LEU 185 119. .300 27, .141 18. .653 1. .00 32. .44 1SG1432
ATOM 1432 CB LEU 185 119. .481 26, .723 17. .183 1. .00 32, .44 1SG1433
ATOM 1433 CG LEU 185 120. .488 27, .589 16. .407 1. .00 32, .44 1SG1434
ATOM 1434 CD2 LEU 185 120, .152 29. .083 16 , .531 1. .00 32, .44 1ΞG1435
ATOM 1435 CDl LEU 185 120, .613 27. .123 14 , .947 1. .00 32, .44 1SG1436
ATOM 1436 C LEU 185 118, .222 26. .270 19, .219 1. .00 32, .44 1SG1437
ATOM 1437 o LEU 185 117, .092 26. .720 19, .392 1 .00 32, .44 1SG1438
ATOM 1438 N ASN 186 118, .539 25, .004 19, .550 1. .00 32 .30 1SG1439
ATOM 1439 CA ASN 186 117 .504 24 .117 20, .002 1 .00 32 .30 1SG1440
ATOM 1440 CB ASN 186 117 .939 22 .646 20 .182 1 .00 32 .30 1SG1441
ATOM 1441 CG ASN 186 118. .996 22. .508 21. .267 1, .00 32, .30 1SG1442
ATOM 1442 ODl ASN 186 120, .165 22. .279 20. .967 1. .00 32, .30 1SG1443
ATOM 1443 ND2 ASN 186 118, .580 22. .627 22. .556 1. .00 32 .30 1SG1444
ATOM 1444 C ASN 186 116, .921 24. .618 21. .283 1, .00 32, .30 1SG1445
ATOM 1445 0 ASN 186 115, .720 24. .490 21, .512 1, .00 32 .30 1SG1446
ATOM 1446 N ALA 187 117, .752 25 .211 22, .156 1 .00 31 .69 1SG1447
ATOM 1447 CA ALA 187 117 .267 25, .679 23, .421 1 .00 31 .69 1SG1448
ATOM 1448 CB ALA 187 118 .367 26 .319 24 .284 1 .00 31 .69 1SG1449
ATOM 1449 C ALA 187 116 .225 26 .723 23, .175 1 .00 31 .69 1SG1450
ATOM 1450 0 ALA 187 115 .224 26 .789 23 .886 1 .00 31 .69 1SG1451
ATOM 1451 N ASN 188 116 .443 27 .578 22 .160 1 .00 34 .39 1SG1452
ATOM 1452 CA ASN 188 115, .530 28, .647 21, .869 1. .00 34, .39 1SG1453
ATOM 1453 CB ASN 188 116, .022 29, .558 20, .732 1, .00 34, .39 1SG1454
ATOM 1454 CG ASN 188 115, .046 30, .719 20, .607 1, .00 34, .39 1SG1455
ATOM 1455 ODl ASN 188 115, .151 31, .718 21, .317 1, .00 34, .39 1SG1456
ATOM 1456 ND2 ASN 188 114, .067 30 .588 19, .672 1 .00 34, .39 1SG1457
ATOM 1457 C ASN 188 114 .197 28 .098 21, .453 1 .00 34, .39 1SG1458
ATOM 1458 0 ASN 188 113 .158 28 .571 21, .905 1 .00 34, .39 1SG1459
ATOM 1459 N LEU 189 114 .191 27 .069 20, .588 1 .00 38 .80 1SG1460
ATOM 1460 CA LEU 189 112 .980 26 .491 20 .073 1 .00 38 .80 1SG1461
ATOM 1461 CB LEU 189 113 .205 25 .418 18 .991 1 .00 38 .80 1SG1462
ATOM 1462 CG LEU 189 113 .623 25 .981 17 .618 1 .00 38 .80 1SG1463
ATOM 1463 CD2 LEU 189 114 .942 26 .760 17 .697 1 .00 38 .80 1SG1464
ATOM 1464 CDl LEU 189 112, .488 26, .806 16, .989 1, .00 38, .80 1SG1465
ATOM 1465 C LEU 189 112, .194 25, .856 21, .179 1, .00 38, .80 1SG1466
ATOM 1466 0 LEU 189 110, .982 25, .697 21, .065 1 .00 38, .80 1SG1467
ATOM 1467 N SER 190 112 .877 25 .415 22, .250 1. .00 43, .73 1SG1468
ATOM 1468 CA SER 190 112 .259 24 .763 23, .372 1, .00 43, .73 1SG1469
ATOM 1469 CB SER 190 113 .279 24, .147 24, .345 1, .00 43, .73 1SG1470 ATOM 1470 OG SER 190 114..009 23..111 23..702 1..00 43..73 1SG1471
ATOM 1471 C SER 190 Ill, .454 25. .752 24. .154 1, .00 43. .73 1SG1472
ATOM 1472 O SER 190 110. .790 25. .387 25. .122 1. .00 43. .73 1SG1473
ATOM 1473 N THR 191 111. .525 27. .037 23. .775 1, .00 48. .67 1SG1474
ATOM 1474 CA THR 191 110. .814 28 .090 24, .439 1. .00 48. .67 1SG1475
ATOM 1475 CB THR 191 111. .190 29. .457 23, .966 1. .00 48. .67 1SG1476
ATOM 1476 OGl THR 191 112. .577 29. .682 24 .158 1. .00 48, .67 1SG1477
ATOM 1477 CG2 THR 191 110. .383 30, .472 24, .785 1, .00 48, .67 1SG1478
ATOM 1478 C THR 191 109. .348 27, .933 24, .184 1. .00 48, .67 1SG1479
ATOM 1479 O THR 191 108. .527 28 .446 24, .943 1 .00 48, .67 1SG1480
ATOM 1480 N LEU 192 108. .985 27, .258 23, .078 1. .00 50, .85 1SG1481
ATOM 1481 CA LEU 192 107. .610 27, .112 22, .697 1, .00 50, .85 1SG1482
ATOM 1482 CB LEU 192 107. .445 26. .214 21, .457 1. .00 50. .85 1SG1483
ATOM 1483 CG LEU 192 106. .006 26, .129 20, .919 1, .00 50. .85 1SG1484
ATOM 1484 CD2 LEU 192 105, .861 24 .995 19, .891 1 .00 50, .85 1SG1485
ATOM 1485 CDl LEU 192 105, .539 27, .490 20, .376 1, .00 50, .85 1SG1486
ATOM 1486 C LEU 192 106, .866 26, .489 23, .848 1, .00 50. .85 1SG1487
ATOM 1487 O LEU 192 107, .360 25. .562 24, .487 1, .00 50, .85 1SG1488
ATOM 1488 N GLU 193 105, .654 27. .005 24, .166 1, .00 51 .12 1SG1489
ATOM 1489 CA GLU 193 104 .978 26 .504 25 .333 1 .00 51 .12 1SG1490
ATOM 1490 CB GLU 193 103, .926 27. .474 25, .898 1, .00 51, .12 1SG1491
ATOM 1491 CG GLU 193 103, .605 27, .207 27, .371 1, .00 51 .12 1SG1492
ATOM 1492 CD GLU 193 104, .759 27, .761 28, .191 1, .00 51, .12 1SG1493
ATOM 1493 OEl GLU 193 105, .707 28, .310 27, .568 1, .00 51 .12 1SG1494
ATOM 1494 OE2 GLU 193 104, .709 27, .643 29 .445 1 .00 51 .12 1SG1495
ATOM 1495 C GLU 193 104, .293 25, .205 25, .034 1, .00 51, .12 1SG1496
ATOM 1496 O GLU 193 103, .513 25 .112 24 .090 1 .00 51 .12 1SG1497
ATOM 1497 N VAL 194 104. .635 24, .137 25, .789 1, .00 49, .51 1SG1498
ATOM 1498 CA VAL 194 103, .973 22, .867 25, .654 1, .00 49 .51 1SG1499
ATOM 1499 CB VAL 194 104, .798 21. .720 26, .158 1, .00 49 .51 1SG1500
ATOM 1500 CGI VAL 194 103, .946 20, .442 26, .090 1, .00 49 .51 1SG1501
ATOM 1501 CG2 VAL 194 106, .084 21, .640 25, .317 1, .00 49 .51 1SG1502
ATOM 1502 C VAL 194 102, .671 22. .859 26, .396 1, .00 49, .51 1SG1503
ATOM 1503 O VAL 194 101, .613 22, .587 25, .831 1, .00 49, .51 1SG1504
ATOM 1504 N LEU 195 102. .723 23. .175 27. .707 1, .00 48, .05 1SG1505
ATOM 1505 CA LEU 195 101, .514 23. .225 28. .474 1, .00 48, .05 1SG1506
ATOM 1506 CB LEU 195 101, .467 22. .317 29. .722 1, .00 48 .05 1SG1507
ATOM 1507 CG LEU 195 101. .403 20, .808 29. .413 1. .00 48, .05 1SG1508
ATOM 1508 CD2 LEU 195 101, .001 20, .001 30. .659 1, .00 48, .05 1SG1509
ATOM 1509 CDl LEU 195 102. .703 20. .309 28. .762 1. .00 48. .05 1SG1510
ATOM 1510 C LEU 195 101. .401 24 , .629 28. .936 1. .00 48, .05 1SG1511
ATOM 1511 O LEU 195 102. .091 25. .056 29. .861 1, .00 48, .05 1SG1512
ATOM 1512 N THR 196 100. .499 25. .386 28. .295 1. .00 48. .89 1SG1513
ATOM 1513 CA THR 196 100. .383 26. .766 28. .637 1. .00 48. .89 1SG1514
ATOM 1514 CB THR 196 100. .055 27. .620 27. .449 1. .00 48. .89 1SG1515
ATOM 1515 OGl THR 196 101. .001 27. .396 26. .414 1. .00 48. .89 1SG1516
ATOM 1516 CG2 THR 196 100, .104 29. .095 27. .881 1. .00 48. .89 1SG1517
ATOM 1517 C THR 196 99. .241 26. .884 29. .590 1. .00 48. .89 1SG1518
ATOM 1518 O THR 196 98. .099 26. .576 29. .255 1. .00 48. .89 1SG1519
ATOM 1519 N LYS 197 99. .536 27. .338 30. ,821 1. ,00 50. .74 1SG1520
ATOM 1520 CA LYS 197 98. .516 27. .490 31. .814 1. ,00 50. .74 1SG1521
ATOM 1521 CB LYS 197 99. .056 27. .231 33. .229 1. .00 50. .74 1SG1522
ATOM 1522 CG LYS 197 98. ,065 27. .489 34. .360 1. .00 50. ,74 1SG1523
ATOM 1523 CD LYS 197 98. .492 26. .837 35. .675 1. .00 50. .74 1SG1524
ATOM 1524 CE LYS 197 97. ,775 27. .406 36. .899 1. .00 50. .74 1SG1525
ATOM 1525 NZ LYS 197 98. ,382 28. .704 37. ,272 1. ,00 50. .74 1SG1526
ATOM 1526 C LYS 197 98. .025 28. .898 31. .723 1. .00 50. .74 1SG1527 ATOM 1527 O LYS 197 98..750 29.,845 32..020 1..00 50.,74 1SG1528
ATOM 1528 N ILE 198 96, .787 29. .057 31. .217 1. ,00 56. .28 1SG1529
ATOM 1529 CA ILE 198 96, .153 30. .331 31. .037 1. .00 56. .28 1SG1530
ATOM 1530 CB ILE 198 95, .032 30. .246 30. .044 1. .00 56. ,28 1SG1531
ATOM 1531 CG2 ILE 198 95, .659 29. .810 28. .711 1. .00 56. .28 1SG1532
ATOM 1532 CGI ILE 198 93, .922 29. .296 30. .525 1. .00 56. .28 1SG1533
ATOM 1533 CDl ILE 198 92 .685 29. .304 29, .626 1. .00 56. .28 1SG1534
ATOM 1534 C ILE 198 95, .655 30. .931 32. .316 1. .00 56. .28 1SG1535
ATOM 1535 O ILE 198 95, .835 32. .126 32. .551 1. .00 56. .28 1SG1536
ATOM 1536 N ASP 199 94 .983 30, .119 33. .160 1. .00 61. .92 1SG1537
ATOM 1537 CA ASP 199 94, .408 30. .625 34. .378 1. ,00 61. .92 1SG1538
ATOM 1538 CB ASP 199 92 .887 30. .765 34. .353 1. .00 61. .92 1SG1539
ATOM 1539 CG ASP 199 92 .450 31. .634 33. .209 1. .00 61. .92 1SG1540
ATOM 1540 ODl ASP 199 92 , .925 32. .794 33. .095 1. ,00 61. .92 1SG1541
ATOM 1541 OD2 ASP 199 91, .605 31. .122 32. .429 1. .00 61. .92 1SG1542
ATOM 1542 C ASP 199 94 .527 29, .548 35, .391 1. .00 61. .92 1SG1543
ATOM 1543 O ASP 199 95, .278 28. .588 35. .246 1. .00 61. .92 1SG1544
ATOM 1544 N ASN 200 93, .763 29. .716 36. .480 1. .00 63. .39 1SG1545
ATOM 1545 CA ASN 200 93 .666 28, .673 37. .442 1. .00 63. .39 1SG1546
ATOM 1546 CB ASN 200 93, .033 29. .109 38. .777 1. .00 63. .39 1SG1547
ATOM 1547 CG ASN 200 91, .617 29, .609 38. .550 1. .00 63. .39 1SG1548
ATOM 1548 ODl ASN 200 91 .230 29, .972 37. .441 1, .00 63 .39 1SG1549
ATOM 1549 ND2 ASN 200 90 .819 29, .648 39 .649 1, .00 63 .39 1SG1550
ATOM 1550 C ASN 200 92. .848 27, .570 36. .826 1. .00 63. .39 1SG1551
ATOM 1551 O ASN 200 93 .030 26, .404 37, .170 1. .00 63. .39 1SG1552
ATOM 1552 N TYR 201 91 .884 27, .924 35 .939 1. .00 64. .29 1SG1553
ATOM 1553 CA TYR 201 90 .979 26, .970 35, .342 1. .00 64, .29 1SG1554
ATOM 1554 CB TYR 201 90 .062 27, .601 34, .279 1. .00 64, .29 1SG1555
ATOM 1555 CG TYR 201 89 .287 28, .798 34 .701 1. .00 64, .29 1SG1556
ATOM 1556 CDl TYR 201 89. .904 30, .018 34, .890 1. .00 64, .29 1SG1557
ATOM 1557 CD2 TYR 201 87 .924 28, .708 34 , .838 1, .00 64, .29 1SG1558
ATOM 1558 CE1 TYR 201 89 .167 31, .125 35 .249 1. .00 64 .29 1SG1559
ATOM 1559 CE2 TYR 201 87. .188 29, .809 35. .195 1. .00 64, .29 1SG1560
ATOM 1560 CZ TYR 201 87, .804 31, .019 35, .403 1. .00 64, .29 1SG1561
ATOM 1561 OH TYR 201 87 .035 32, .145 35, .767 1. .00 64 .29 1SG1562
ATOM 1562 C TYR 201 91 .654 25 .990 34 .426 1. .00 64 .29 1SG1563
ATOM 1563 O TYR 201 91, .780 24 , .804 34, .729 1. .00 64, .29 1SG1564
ATOM 1564 N THR 202 92 .163 26, .492 33, .279 1, .00 60, .99 1SG1565
ATOM 1565 CA THR 202 92 .582 25, .574 32, .255 1. .00 60, .99 1SG1566
ATOM 1566 CB THR 202 91, .643 25, .502 31, .087 1. .00 60, .99 1SG1567
ATOM 1567 OGl THR 202 91 .592 26, .751 30, .415 1. .00 60, .99 1SG1568
ATOM 1568 CG2 THR 202 90 .251 25, .098 31, .609 1, .00 60, .99 1SG1569
ATOM 1569 C THR 202 93 , .923 25. .921 31, .703 1. .00 60, .99 1SG1570
ATOM 1570 O THR 202 94, .579 26, .869 32, .132 1. .00 60, .99 1SG1571
ATOM 1571 N LEU 203 94 .357 25, .086 30, .733 1. .00 58, .45 1SG1572
ATOM 1572 CA LEU 203 95, .653 25. .163 30. .128 1. .00 58. .45 1SG1573
ATOM 1573 CB LEU 203 96, .629 24. .106 30. .676 1. .00 58. .45 1SG1574
ATOM 1574 CG LEU 203 96 .537 23, .919 32, .200 1. .00 58. .45 1SG1575
ATOM 1575 CD2 LEU 203 95 .238 23, .174 32. .583 1. .00 58. .45 1SG1576
ATOM 1576 CDl LEU 203 96, .768 25. .238 32. .948 1. .00 58. .45 1SG1577
ATOM 1577 C LEU 203 95 .453 24 , .747 28, .706 1. .00 58, .45 1SG1578
ATOM 1578 O LEU 203 94 .390 24. .242 28, .348 1. .00 58, .45 1SG1579
ATOM 1579 N LEU 204 96, .480 24. .951 27. .859 1. .00 58. .76 1SG1580
ATOM 1580 CA LEU 204 96, .397 24, .544 26. .489 1. .00 58. .76 1SG1581
ATOM 1581 CB LEU 204 96, .689 25, .692 25. .526 1. .00 58. .76 1SG1582
ATOM 1582 CG LEU 204 95, .833 26. .934 25. .785 1. ,00 58. .76 1SG1583
ATOM 1583 CD2 LEU 204 94 , .363 26. .557 26. .029 1. .00 58. .76 1SG1584 ATOM 1584 CDl LEU 204 96.,053 27,.963 24.,665 1.00 58.76 1SG1585
ATOM 1585 C LEU 204 97. 519 23. .575 26. .262 1. 00 58. ,76 1SG1586
ATOM 1586 O LEU 204 98. ,631 23. .776 26. .750 1. 00 58. 76 1SG1587
ATOM 1587 N ASP 205 97. 257 22, .495 25. .501 1. 00 59. ,79 1SG1588
ATOM 1588 CA ASP 205 98. ,281 21. .523 25. .239 1. 00 59. ,79 1SG1589
ATOM 1589 CB ASP 205 97. ,769 20. .075 25. .361 1. 00 59. ,79 1SG1590
ATOM 1590 CG ASP 205 98. ,924 19, .116 25. .100 1. 00 59. ,79 1SG1591
ATOM 1591 ODl ASP 205 100. .080 19, .595 24. .934 1. ,00 59. .79 1SG1592
ATOM 1592 OD2 ASP 205 98. .665 17, .885 25. .072 1. 00 59. .79 1SG1593
ATOM 1593 C ASP 205 98. .773 21. .731 23. .832 1. .00 59. .79 1SG1594
ATOM 1594 O ASP 205 98. ,140 21, .298 22. .873 1. .00 59. .79 1SG1595
ATOM 1595 N TYR 206 99. .900 22, .462 23. .702 1. .00 62. .56 1SG1596
ATOM 1596 CA TYR 206 100. .662 22, .806 22, .527 1. .00 62. .56 1SG1597
ATOM 1597 CB TYR 206 101. .425 24, .139 22. .608 1. .00 62. .56 1SG1598
ATOM 1598 CG TYR 206 100. .392 25, .211 22. .514 1. .00 62. .56 1SG1599
ATOM 1599 CDl TYR 206 99. .581 25, .279 21. .402 1. .00 62. .56 1SG1600
ATOM 1600 CD2 TYR 206 100. .247 26, .157 23. .501 1. .00 62, .56 1SO1601
ATOM 1601 CE1 TYR 206 98, .621 26 .256 21. .277 1. .00 62, .56 1SG1602
ATOM 1602 CE2 TYR 206 99, .289 27, .138 23 .380 1, .00 62 .56 1SG1603
ATOM 1603 CZ TYR 206 98. .475 27 .189 22 .275 1. .00 62 .56 1SG1604
ATOM 1604 OH TYR 206 97, .500 28, .202 22 .169 1. .00 62 .56 1SG1605
ATOM 1605 C TYR 206 101, .598 21 .719 22 .070 1. .00 62 .56 1SG1606
ATOM 1606 O TYR 206 102. .329 21, .913 21, .101 1. .00 62, .56 1SG1607
ATOM 1607 N SER 207 101. .751 20, .634 22, .853 1. .00 60, .54 1SG1608
ATOM 1608 CA SER 207 102. .733 19, .613 22. .569 1. .00 60, .54 1SG1609
ATOM 1609 CB SER 207 102. .647 18, .397 23. .513 1. .00 60, .54 1SG1610
ATOM 1610 OG SER 207 101. .405 17, .727 23. .344 1. .00 60 .54 1SG1611
ATOM 1611 C SER 207 102. .663 19 .101 21. .160 1. .00 60, .54 1SG1612
ATOM 1612 O SER 207 101. .590 18 .932 20. .582 1. .00 60 .54 1SG1613
ATOM 1613 N LEU 208 103. .856 18 .846 20 .570 1. .00 56, .30 1SG1614
ATOM 1614 CA LEU 208 103, .963 18 .335 19. .230 1, .00 56 .30 1SG1615
ATOM 1615 CB LEU 208 105. .374 18 .434 18 .625 1. .00 56, .30 1SG1616
ATOM 1616 CG LEU 208 105. .853 19 .874 18. .363 1. .00 56 .30 1SG1617
ATOM 1617 CD2 LEU 208 107, .136 19 .877 17 .515 1, .00 56 .30 1SG1618
ATOM 1618 CDl LEU 208 105, .994 20 .673 19 .670 1. .00 56 .30 1SG1619
ATOM 1619 C LEU 208 103. .577 16 .890 19 .223 1. .00 56 .30 1SG1620
ATOM 1620 O LEU 208 104, .049 16 .097 20 .035 1. .00 56 .30 1SG1621
ATOM 1621 N ILE 209 102, .655 16 .542 18 .306 1, .00 50 .56 1SG1622
ATOM 1622 CA ILE 209 102 .150 15 .219 18 .077 1, .00 50 .56 1SG1623
ATOM 1623 CB ILE 209 100, .867 15 .212 17 .298 1, .00 50 .56 1SG1624
ATOM 1624 CG2 ILE 209 101 .168 15 .701 15 .872 1, .00 50 .56 1SG1625
ATOM 1625 CGI ILE 209 100, .212 13 .822 17 .357 1 .00 50 .56 1SG1626
ATOM 1626 CDl ILE 209 98 .760 13 .808 16 .880 1, .00 50 .56 1SG1627
ATOM 1627 C ILE 209 103 .133 14 .366 17 .341 1 .00 50 .56 1SG1628
ATOM 1628 O ILE 209 103, .169 13 .157 17 .553 1. .00 50, .56 1SG1629
ATOM 1629 N SER 210 103, .891 14, .958 16. .392 1. .00 42. .51 1SG1630
ATOM 1630 CA SER 210 104. .813 14 .196 15 .595 1. .00 42, .51 1SG1631
ATOM 1631 CB SER 210 104. .219 13 .722 14, .257 1. .00 42 .51 1SG1632
ATOM 1632 OG SER 210 103. .885 14 .842 13 .449 1. .00 42, .51 1SG1633
ATOM 1633 C SER 210 105. .984 15 .070 15 .272 1, .00 42 .51 1SG1634
ATOM 1634 O SER 210 106, .012 16 .248 15 .624 1, .00 42, .51 1SG1635
ATOM 1635 N SER 211 107, .001 14 .496 14 .596 1, .00 38 .13 1SG1636
ATOM 1636 CA SER 211 108, .184 15 .238 14 .261 1. .00 38 .13 1SG1637
ATOM 1637 CB SER 211 109, .336 14 .355 13 .755 1, .00 38 .13 1SG1638
ATOM 1638 OG SER 211 110. .468 15, .156 13 .448 1. .00 38 .13 1SG1639
ATOM 1639 C SER 211 107. .842 16 .211 13 .183 1. .00 38 .13 1SG1640
ATOM 1640 O SER 211 106, .901 16. .011 12 .418 1, .00 38 .13 1SG1641 H H H H H H H H H H H H H H H H H H H H H H HH H H H H H H H H H H H H H H H H H H HH H H H H H H H H H H HH H O Odd dd d Od dd dPP dd dOP PP PdPPO PPP PP P PP P PdPd PP PPPPPddd PP QddOd d 323323323322332323222223222222322222222323223222222333333
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H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H o o o o o o o oo o o o o o oo o o o o H O O O O O O O O O O O O O O H O O O O O O O O O O O O O O O O O O w w i ιt* ιt* ^ υι σ -] o -] θ co -] σ o o ιo 00 VD O VO ^I ^I OO OO VO OO UI UI OI OO OO VD VO UJ ID lD -l Ol vJ O O Ol O -l O lO C- lD lD lO CO OO ui _ vD H in oi to ^i H to 4* oi -4 Ul IO 00 o o ui o ui vo vo -J H Oo ^i -j iD Ui o oi ui w o iπ oi w o u co ui ui en H H O oo on σi σi ui H to uJ ui
O t0 4* VO O UJ 4* -J OO U1 0 ^J 4* 4* ui to to Ul -J VO O t H UJ 01 VD Cn v0 ^1 VO O it» UI 4* O1 00 U> H UJ 00 H H H 01 00 4* H ω V0 UJ O t0 V0 H 4* VD
4* σι uι uι iD vo -j σι ui 4* o 4* H H O 01 H -J VD 4* tO 4* UJ H t H Ul H 4* O1 4* 00 _l Ul H tO -j αj Ol H tO 4* 4* H tO Ul Ul Ul Ul VD U1 0 Ul -J O VD -. 0 tO tO tO tO tO tO IO tO tO tO tO tO tO t tO tO tO tO tO H tO H tO tO tO tO tO tO H H to H ( H H H tO tO H H H H H H H H H H H H H tO tO UI Ul 4* 4* 4* 01 Ui αi Ul Ul -l ιt* UJ Ul UJ αJ O lD O H H O H O lO VO O VD O ^] VO VD O O VO VD OO IO OO UJ 4* 4* in en ^i oo -1 -J ID ID ^ CO ^
4* 4* uι uι σι σι co σι ui ιt* uJ ιt* vD -J oo vo uι ^] o en oo co o ι_> ι4^* _πι oe»o o(_ι ounι --j vιoo uiΛJJ θioo oι_j ιioD oi_j lD θ m _l 4* UJ ^J _1 00 ιb Ui σi V0 Ul O H ^] UI 4* 00 tO t0 _i oi ui uJ to to o oo H oooo HH iinn ttoo **.. ttoo ^^iι oσiι uuJJ uuiι ^] H U UJJ ^-j] ^^ii oooo uuii DD OOii vvoo oonn vvoo ^^ii oooo 44** oooo on ui oo vo to oo ^i ui H -j en 4* to to uι to ui 4* o- to oo -j
U1 0 0 4* 0 4* H U1 i iD θ * ι u u * -j μ i -J ^l CD OO Ul VO Cn cO lD OO tO OO H tO Ul H OO ln tO Ul Ul ^l ^l tO UJ H 4* tO l0 4* 4* tO NJ tO tO H H O O O O O Ul UI UI tO IO O O H H H UI tO tO UI 4* 4* ^] ^) 4* Ul Ul Cn ^! -J VO -J OO OO -j eX) V0 0 0 4* t0 4* tO UJ u - CΛ ω w oι u M oι u o .ι iD ^ u _ u ι_ ι» (n u w iΛ o J w ^ ιn * Φ θι oι co o * ι W i θ) α) ^ j ι iv w ιji φ tι ii) Ui o ιjι u μ μ to t UJ <n vD 0n 4* H 00 M O UJ tO t0 t0 O 4* t0 M H VD H H O O 01 VD ln Ul H H ^ UJ i»> lI) in H VD CD Ul tO t0 H ln UJ VD 0n 01 00 O 4* Ul Ul t H UI H
-J ui vD vo to to oi ui vo cn -j i^ H ^ ^ vD O cn H o o in en uJ Ui ^ iD Oo oo ui ^i en H to uJ O H O oo ui UJ H cn -j en oo H 4* ui co 4* vo -j oo o o ui
H H H H H H H H H H H H H H H H H o o o o o o o o o o o o o o o o ooooo ooooooooooooooo oooooooooo ooooooooooo o o o o o o o o o o o o o o o o o o o o o oo o oo oo o oo o oo oo o oo oo oo o oo o o o oo oo o ooo
4* 4* 4* 4* 1^ 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* vD vo vo vo vo vo vo vD VD on σi σi σi σi σi σi 01 4* 4* 4* 4* 4* 4* 4* 4* 4* to to to to to to to vD vo vD vo vD vo vD io on σι σι σι σ σι σι σι σι σι σ σι o σι σι σι o o i o o o i J o m J CD co cD ai co co co cD ω D co m ω ii ffl O j i -J -J
00 C0 C0 00 00 00 CD 00 CO VD VO VO lO VD VO VO VD ι& ιf. 4* 4* 4* 4* 4* 4* 4* H H H H H
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H to to to to to to to to to to to to to to to to to to to to to to to to to to to to cn to to to to to to to to crj to w to to w to to to to to to to to -i to to to to w
Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ Ω Ώ Ω Ω Ώ Ω Ω Ώ Ω Ω Ώ Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ Ω Ω Ω Ω Ω ΩΩΩ ΩΩ ΩΏ ΏΩΩΏ ΩΩ
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ' ' σi σi σi σi σ σi cn σi σi σi σi tn σi σi σi σi σi σi σi σ σ σi σi σi σi σi σ σi σi σi cn σi σi -i cn σ σi σi σi cn cn σi σi en cn o σi σi σi σi σi σ cn cn σ σi σ^ io iD _ iD io iD io iD _ (» co ω _ c» co ω (B α) si o ^ j θ sj o o ^ o ι_ oι oι oι cn oι oι _ cn ι_ ιn ιn _ ω _ w ιn ιn ιn ιt> ft ft ιi* * *ι ιi* * CD ^ αι 4* UJ tθ H θ vD θo -j en ιn 4* UJ t H θ VD ∞ ^ (n 4* uJ t H θ io ω ^ σι uι 4* u to H θ vo oo j en ui 4* uJ to H θ vD CD -j σι ui 4* UJ to
ATOM 1698 OH TYR 218 102.924 20.363 1.694 1.00 49.78 1SG1699
ATOM 1699 C TYR 218 107. 290 23. 706 5. 223 1. 00 49. 78 1SG1700
ATOM 1700 O TYR 218 107. ,490 22. 530 4. 926 1. 00 49. 78 1SG1701
ATOM 1701 N LEU 219 107. ,526 24. 190 6. 461 1. 00 50. ,26 1SG1702
ATOM 1702 CA LEU 219 107. 932 23. ,318 7. .524 1. 00 50. 26 1SG1703
ATOM 1703 CB LEU 219 108. ,987 23. ,936 8. 458 1. 00 50. ,26 1SG1704
ATOM 1704 CG LEU 219 109. ,663 22. ,981 9. .463 1. 00 50. ,26 1SG1705
ATOM 1705 CD2 LEU 219 108. .751 21. ,846 9. ,944 1. ,00 50. .26 1SG1706
ATOM 1706 CDl LEU 219 110. ,293 23. .776 10. ,613 1. .00 50. .26 1SG1707
ATOM 1707 C LEU 219 106. ,673 23. .156 8. ,322 1. ,00 50. .26 1SG1708
ATOM 1708 O LEU 219 106. ,123 24, .137 8. ,822 1. ,00 50. .26 1SG1709
ATOM 1709 N ASP 220 106. .170 21. ,912 8. 449 1. 00 47. .89 1SG1710
ATOM 1710 CA ASP 220 104. .915 21. .717 9. ,121 1. 00 47. ,89 1SG1711
ATOM 1711 CB ASP 220 103. .986 20. .719 8. .409 1. 00 47. .89 1SG1712
ATOM 1712 CG ASP 220 103. .482 21. .392 7. .143 1. ,00 47. .89 1SG1713
ATOM 1713 ODl ASP 220 103. .642 22. .638 7. .047 1. 00 47. .89 1SG1714
ATOM 1714 OD2 ASP 220 102. .926 20. .681 6. .264 1. .00 47, .89 1SG1715
ATOM 1715 C ASP 220 105, .125 21. .213 10. .515 1. .00 47. .89 1SG1716
ATOM 1716 O ASP 220 105, ,890 20. .279 10. .749 1. .00 47. .89 1SG1717
ATOM 1717 N LEU 221 104, .432 21. ,845 11. ,485 1. .00 46. .12 1SG1718
ATOM 1718 CA LEU 221 104, .513 21, .447 12. .863 1. .00 46. .12 1SG1719
ATOM 1719 CB LEU 221 104 .968 22 .591 13. .788 1. .00 46. .12 1SG1720
ATOM 1720 CG LEU 221 106, .365 23. .149 13, .452 1. .00 46. .12 1SG1721
ATOM 1721 CD2 LEU 221 107 .415 22 .026 13, .382 1. .00 46. .12 1SG1722
ATOM 1722 CDl LEU 221 106 .760 24. .282 14, .415 1, .00 46 .12 1SG1723
ATOM 1723 C LEU 221 103 .125 21 .067 13, .306 1. .00 46, .12 1SG1724
ATOM 1724 O LEU 221 102 , .181 21, .842 13. .152 1. .00 46, .12 1SG1725
ATOM 1725 N ASN 222 102, .960 19 .858 13. .883 1. .00 41, .82 1SG1726
ATOM 1726 CA ASN 222 101, .655 19, .437 14, .321 1. .00 41, .82 1SG1727
ATOM 1727 CB ASN 222 101, .303 18 .000 13. .903 1. .00 41, .82 1SG1728
ATOM 1728 CG ASN 222 101 .113 17, .986 12. ,394 1, .00 41 .82 1SG1729
ATOM 1729 ODl ASN 222 101 .734 17 .196 11. .684 1. .00 41, .82 1SG1730
ATOM 1730 ND2 ASN 222 100 .227 18 .885 11. .889 1. .00 41 .82 1SG1731
ATOM 1731 C ASN 222 101 .612 19 .486 15 .819 1. .00 41 .82 1SG1732
ATOM 1732 O ASN 222 102 .502 18 .970 16. .493 1, .00 41 .82 1SG1733
ATOM 1733 N LEU 223 100 .562 20 .125 16 .376 1, .00 39 .34 1SG1734
ATOM 1734 CA LEU 223 100 .437 20 .251 17 .806 1, .00 39 .34 1SG1735
ATOM 1735 CB LEU 223 100 .479 21 .711 18 .296 1, .00 39 .34 1SG1736
ATOM 1736 CG LEU 223 101 .807 22 .424 17 .982 1. .00 39 .34 1SG1737
ATOM 1737 CD2 LEU 223 103 .013 21 .596 18 .452 1 .00 39 .34 1SG1738
ATOM 1738 CDl LEU 223 101 .816 23 .862 18 .526 1, .00 39 .34 1SG1739
ATOM 1739 C LEU 223 99 .107 19 .684 18 .220 1, .00 39 .34 1SG1740
ATOM 1740 O LEU 223 98 .183 19 .597 17 .414 1. .00 39 .34 1SG1741
ATOM 1741 N LYS 224 98 .986 19 .264 19 .500 1, .00 40 .64 1SG1742
ATOM 1742 CA LYS 224 97 .770 18 .684 20 .017 1, .00 40, .64 1SG1743
ATOM 1743 CB LYS 224 97 .920 18 .204 21 .471 1. .00 40 .64 1SG1744
ATOM 1744 CG LYS 224 96 .659 17 .551 22 .042 1, .00 40 .64 1SG1745
ATOM 1745 CD LYS 224 96 .321 16 .203 21 .406 1 .00 40 .64 1SG1746
ATOM 1746 CE LYS 224 94 .960 15 .645 21 .826 1, .00 40 .64 1SG1747
ATOM 1747 NZ LYS 224 94 .957 15 .342 23 .273 1 .00 40 .64 1SG1748
ATOM 1748 C LYS 224 96 .648 19 .689 19 .985 1 .00 40 .64 1SG1749
ATOM 1749 O LYS 224 95 .576 19 .413 19 .450 1 .00 40 .64 1SG1750
ATOM 1750 N GLY 225 96 .866 20 .896 20 .542 1 .00 44 .01 1SG1751
ATOM 1751 CA GLY 225 95 .892 21 .956 20 .480 1 .00 44 .01 1SG1752
ATOM 1752 C GLY 225 94 .588 21 .638 21 .163 1 .00 44 .01 1SG1753
ATOM 1753 O GLY 225 93 .535 21 .708 20 .527 1 .00 44 .01 1SG1754
ATOM 1754 N VAL 226 94 .600 21 .277 22 .460 1 .00 50 .60 1SG1755 ATOM 1755 CA VAL 226 93..345 21.064 23.,127 1.00 50..60 1SG1756
ATOM 1756 CB VAL 226 93. .041 19. ,616 23. .354 1. .00 50. .60 1SG1757
ATOM 1757 CGI VAL 226 91. .688 19. ,510 24. .077 1. .00 50. .60 1SG1758
ATOM 1758 CG2 VAL 226 93. .110 18. ,884 22. .003 1. .00 50. .60 1SG1759
ATOM 1759 C VAL 226 93. .439 21. .699 24. .482 1. ,00 50. .60 1SG1760
ATOM 1760 O VAL 226 94. .471 21. .605 25. .147 1. ,00 50. .60 1SG1761
ATOM 1761 N PHE 227 92. .353 22. ,370 24. .934 1. .00 57. .61 1SG1762
ATOM 1762 CA PHE 227 92. .330 22. .930 26. .259 1. ,00 57. .61 1SG1763
ATOM 1763 CB PHE 227 91. .110 23. ,828 26. .566 1. ,00 57. .61 1SG1764
ATOM 1764 CG PHE 227 91. .242 25. ,158 25. .897 1. .00 57, .61 1SG1765
ATOM 1765 CDl PHE 227 91. .105 25. .283 24. .535 1. .00 57, .61 1SG1766
ATOM 1766 CD2 PHE 227 91. .473 26. .291 26, .647 1. .00 57, .61 1SG1767
ATOM 1767 CE1 PHE 227 91. .221 26. .515 23, .935 1. .00 57, .61 1SG1768
ATOM 1768 CE2 PHE 227 91. .587 27. .526 26, .051 1. .00 57, .61 1SG1769
ATOM 1769 CZ PHE 227 91. .463 27. .639 24, .689 1. .00 57, .61 1SG1770
ATOM 1770 C PHE 227 92, .225 21. .751 27, .166 1. .00 57, .61 1SG1771
ATOM 1771 O PHE 227 91, .580 20. .757 26. .831 1. .00 57, .61 1SG1772
ATOM 1772 N TYR 228 92. .879 21. .834 28. .335 1. .00 61 .58 1SG1773
ATOM 1773 CA TYR 228 92 .959 20. .709 29 .215 1. .00 61 .58 1SG1774
ATOM 1774 CB TYR 228 94 .349 20, .108 28 .939 1. .00 61 .58 1SG1775
ATOM 1775 CG TYR 228 94 .868 19, .094 29 .878 1. .00 61 .58 1SG1776
ATOM 1776 CDl TYR 228 94 .259 17, .877 30 .075 1. .00 61 .58 1SG1777
ATOM 1777 CD2 TYR 228 96. .054 19. .381 30, .505 1. .00 61, .58 1SG1778
ATOM 1778 CE1 TYR 228 94. .827 16. .976 30. .944 1. .00 61, .58 1SG1779
ATOM 1779 CE2 TYR 228 96. .623 18. .484 31, .372 1. .00 61, .58 1SG1780
ATOM 1780 CZ TYR 228 96. .001 17. .279 31, .592 1. .00 61, .58 1SG1781
ATOM 1781 OH TYR 228 96. .578 16. .349 32. .479 1. .00 61 .58 1SG1782
ATOM 1782 C TYR 228 92. .751 21. .188 30, .628 1. .00 61, .58 1SG1783
ATOM 1783 O TYR 228 93 .111 22. .314 30 .965 1. .00 61 .58 1SG1784
ATOM 1784 N PRO 229 92. .026 20. .429 31, .415 1. .00 58 .42 1SG1785
ATOM 1785 CA PRO 229 91 .891 20, .786 32 .814 1. .00 58 .42 1SG1786
ATOM 1786 CD PRO 229 90 .762 19. .960 30 .869 1, .00 58 .42 1SG1787
ATOM 1787 CB PRO 229 90 .456 20. .449 33 .214 1, .00 58 .42 1SG1788
ATOM 1788 CG PRO 229 89 .694 20. .382 31 .884 1. .00 58 .42 1SG1789
ATOM 1789 C PRO 229 92 .865 20. .056 33 .699 1. .00 58 .42 1SG1790
ATOM 1790 0 PRO 229 93 .068 18. .864 33 .472 1, .00 58 .42 1SG1791
ATOM 1791 N LEU 230 93 .462 20. .712 34 .722 1. .00 52 .12 1SG1792
ATOM 1792 CA LEU 230 94 .255 19. .968 35 .669 1. .00 52 .12 1SG1793
ATOM 1793 CB LEU 230 95 .200 20. .766 36 .594 1, .00 52 .12 1SG1794
ATOM 1794 CG LEU 230 96 .576 21. .167 36 .025 1, .00 52 .12 1SG1795
ATOM 1795 CD2 LEU 230 96 .508 22. .374 35 .093 1. .00 52 .12 1SG1796
ATOM 1796 CDl LEU 230 97 .317 19. .947 35 .451 1. .00 52 .12 1SG1797
ATOM 1797 C LEU 230 93 .377 19 .219 36 .620 1. .00 52 .12 1ΞG1798
ATOM 1798 O LEU 230 93 .663 18. .075 36 .969 1, .00 52 .12 1SG1799
ATOM 1799 N GLU 231 92 .289 19. .865 37 .086 1. .00 44 .09 1SG1800
ATOM 1800 CA GLU 231 91, .497 19. .274 38 .127 1. .00 44, .09 1SG1801
ATOM 1801 CB GLU 231 90, .337 20. .163 38 .614 1. .00 44, .09 1SG1802
ATOM 1802 CG GLU 231 90, .809 21. .381 39, .410 1. .00 44, .09 1SG1803
ATOM 1803 CD GLU 231 89 .599 22. .006 40 .090 1. .00 44, .09 1SG1804
ATOM 1804 OEl GLU 231 88 .852 21, .259 40 .775 1. .00 44, .09 1SG1805
ATOM 1805 OE2 GLU 231 89, .409 23. .241 39 .933 1. .00 44, .09 1SG1806
ATOM 1806 C GLU 231 90 .922 17. .978 37 .677 1. .00 44, .09 1SG1807
ATOM 1807 0 GLU 231 90 .988 16, .990 38 .406 1. .00 44, .09 1SG1808
ATOM 1808 N ASN 232 90, .337 17, .929 36 .469 1. .00 37, .51 1SG1809
ATOM 1809 CA ASN 232 89 .796 16, .670 36 .058 1. .00 37, .51 1SG1810
ATOM 1810 CB ASN 232 88 .278 16, .550 36 .272 1. .00 37, .51 1SG1811
ATOM 1811 CG ASN 232 87 .930 15, .067 36 .282 1. .00 37, .51 1SG1812 ATOM 1812 ODl ASN 232 88.777 14.233 36.598 1..00 37..51 1SG1813
ATOM 1813 ND2 ASN 232 86 .660 14, .727 35 .933 1. .00 37, .51 1SG1814
ATOM 1814 C ASN 232 90 .055 16 .538 34 .594 1. .00 37. .51 1SG1815
ATOM 1815 O ASN 232 89 .962 17 .508 33 .845 1 .00 37 .51 1SG1816
ATOM 1816 N LEU 233 90 .385 15 .313 34 .149 1 .00 37 .36 1SG1817
ATOM 1817 CA LEU 233 90 .701 15 .086 32 .771 1 .00 37 .36 1SG1818
ATOM 1818 CB LEU 233 91 .877 14 .102 32 .599 1 .00 37, .36 1SG1819
ATOM 1819 CG LEU 233 92 .233 13 .716 31 .146 1. .00 37, .36 1SG1820
ATOM 1820 CD2 LEU 233 92 .400 14 .961 30 .267 1. .00 37, .36 1SG1821
ATOM 1821 CDl LEU 233 91 .243 12 .706 30 .541 1. .00 37, .36 1SG1822
ATOM 1822 C LEU 233 89 .507 14 .486 32 .110 1, .00 37, .36 1SG1823
ATOM 1823 O LEU 233 88. .955 13 .495 32 .585 1, .00 37, .36 1SG1824
ATOM 1824 N THR 234 89 .071 15 .094 30 .991 1 .00 39 .77 1SG1825
ATOM 1825 CA THR 234 87 .984 14 .550 30 .234 1 .00 39 .77 1SG1826
ATOM 1826 CB THR 234 86 .681 15 .256 30 .479 1 .00 39. .77 1SG1827
ATOM 1827 OGl THR 234 86 .792 16 .625 30 .117 1, .00 39, .77 1SG1828
ATOM 1828 CG2 THR 234 86 .316 15 .131 31 .969 1, .00 39, .77 1SG1829
ATOM 1829 C THR 234 88 .331 14 .744 28 .788 1, .00 39, .77 1SG1830
ATOM 1830 O THR 234 88 .706 15, .841 28 .378 1, .00 39. .77 1SG1831
ATOM 1831 N ASP 235 88 .227 13, .676 27 .972 1, .00 43, .72 1SG1832
ATOM 1832 CA ASP 235 88 .556 13, .810 26 .580 1, .00 43, .72 1SG1833
ATOM 1833 CB ASP 235 88 .964 12 .482 25 .922 1 .00 43 .72 1SG1834
ATOM 1834 CG ASP 235 90 .324 12 .105 26 .493 1 .00 43 .72 1SG1835
ATOM 1835 ODl ASP 235 91 .042 13 .034 26 .950 1 .00 43 .72 1SG1836
ATOM 1836 OD2 ASP 235 90 .664 10 .892 26 .483 1, .00 43 .72 1SG1837
ATOM 1837 C ASP 235 87 .365 14 .359 25 .854 1, .00 43, .72 1SG1838
ATOM 1838 O ASP 235 86 .223 14, .181 26 .273 1, .00 43, .72 1SG1839
ATOM 1839 N PRO 236 87. .621 15, .052 24 .776 1, .00 48, .63 1SG1840
ATOM 1840 CA PRO 236 86. .535 15, .601 24 .007 1, .00 48, .63 1SG1841
ATOM 1841 CD PRO 236 88. .776 15, .931 24, .749 1, .00 48, .63 1SG1842
ATOM 1842 CB PRO 236 87 .106 16 .782 23 .221 1 .00 48 .63 1SG1843
ATOM 1843 CG PRO 236 88 .628 16 .693 23 .427 1, .00 48, .63 1SG1844
ATOM 1844 C PRO 236 85 .817 14, .577 23 .184 1. .00 48, .63 1SG1845
ATOM 1845 O PRO 236 86 .425 13, .612 22 .725 1, .00 48, .63 1SG1846
ATOM 1846 N PRO 237 84. .549 14, .804 22, .994 1, .00 49, .84 1SG1847
ATOM 1847 CA PRO 237 83. .716 13 , .884 22, .266 1, .00 49, .84 1SG1848
ATOM 1848 CD PRO 237 83. .794 15, .522 24, .010 1, .00 49, .84 1SG1849
ATOM 1849 CB PRO 237 82, .278 14. .287 22, .579 1, .00 49. .84 1SG1850
ATOM 1850 CG PRO 237 82, .374 14. .937 23, .968 1. .00 49. .84 1SG1851
ATOM 1851 C PRO 237 83 .997 13. .830 20 .802 1. .00 49. .84 1SG1852
ATOM 1852 O PRO 237 83, .410 12, .993 20, .123 1, .00 49. .84 1SG1853
ATOM 1853 N PHE 238 84, .849 14 , .711 20, .269 1. .00 47. .25 1SG1854
ATOM 1854 CA PHE 238 85, .014 14 , .720 18, .847 1. .00 47. .25 1SG1855
ATOM 1855 CB PHE 238 84, .369 15. .970 18. .239 1. .00 47. .25 1SG1856
ATOM 1856 CG PHE 238 84. .797 17. .062 19. .152 1. .00 47. .25 1SG1857
ATOM 1857 CDl PHE 238 86. .075 17. .548 19. .109 1. .00 47. .25 1SG1858
ATOM 1858 CD2 PHE 238 83. .941 17. .568 20. .097 1. .00 47. .25 1SG1859
ATOM 1859 CE1 PHE 238 86. .491 18. .542 19. .960 1. .00 47. ,25 1SG1860
ATOM 1860 CE2 PHE 238 84. .347 18. .565 20, .951 1. .00 47. .25 1SG1861
ATOM 1861 CZ PHE 238 85. .623 19. .059 20, .885 1. .00 47. .25 1SG1862
ATOM 1862 C PHE 238 86. .468 14. .655 18. .486 1. .00 47. .25 1SG1863
ATOM 1863 O PHE 238 87. .332 14. .609 19. .359 1. .00 47. ,25 1SG1864
ATOM 1864 N SER 239 86. .766 14. ,597 17. .167 1. ,00 43. .39 1SG1865
ATOM 1865 CA SER 239 88. .127 14. .522 16. .705 1. ,00 43. .39 1SG1866
ATOM 1866 CB SER 239 88. .417 13. .293 15. ,829 1. .00 43. .39 1SG1867
ATOM 1867 OG SER 239 88. .300 12. .106 16. ,599 1. .00 43. 39 1SG1868
ATOM 1868 C SER 239 88. .401 15. ,734 15. .865 1. 00 43. 39 1SG1869 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H o o d o p p p d d o d p d d p o p p p p p p p p d p p p p d d d o d d o d p d p p d p p p p p p p p p p d d d d p
232222222222222222333333333333333223222222222222233222222
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H lO VD VD VO VD lO VD VD VO VD VD lO lD VO VO lD VD VO VD VO VO VD lO VD VD Vθ α3 00 CO 03 00 0O 00 00 00 00 CO CO CD OD CD CD _. 00 O3 ∞ tO M M tO tO t0 H H H H H H H H H H O O O O O O O O O O VD V0 lD VD V0 VO l0 V0 VD VD 00 00 00 00 00 00 00 00 03 00 -J -J -J J -J -J ~J -J -J -J -l ui 4* w to H O vo oo -j oi in it* UJ to H o vD CD J cn in 4* J M H o vo oo -j cn in ifc ui tO H O VD Oo ^ en in 4* ui tO H o vD Oo -j oi ui 4* uJ to H O VD > G 3 Ω Ω Ω Ω Ω 3 Ω Ω Ω Ω Ω Ω 3 Ω Ω Ω Ω Ω 3 P Ω Ω Ω Ω Ω Ω Ω Ω Ω 3 Ω Ω Ω Ω Ω 3 P Ω Ω Ω Ω Ω 3 P Ω Ω Ω Ω Ω 3 P
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Figure imgf000556_0002
ATOM 2040 CB PHE 261 91.697 24,.418 18..984 1,.00 46..27 1SG2041
ATOM 2041 CG PHE 261 92 .449 25. .198 20, .010 1. .00 46. .27 1SG2042
ATOM 2042 CDl PHE 261 93 .369 24. .584 20, .829 1. .00 46. .27 1SG2043
ATOM 2043 CD2 PHE 261 92 .253 26, .556 20, .131 1. .00 46. .27 1SG2044
ATOM 2044 CE1 PHE 261 94 .067 25, .310 21, .765 1. .00 46, .27 1SG2045
ATOM 2045 CE2 PHE 261 92 .950 27, .287 21. .065 1. .00 46, .27 1SG2046
ATOM 2046 CZ PHE 261 93 .857 26, .663 21. .888 1, .00 46, .27 1SG2047
ATOM 2047 C PHE 261 89 .692 24, .480 20. .412 1, .00 46, .27 1SG2048
ATOM 2048 O PHE 261 89 .706 24, .515 21. .641 1, .00 46, .27 1SG2049
ATOM 2049 N PHE 262 88 .845 25, .229 19. .684 1, .00 48, .47 1SG2050
ATOM 2050 CA PHE 262 87 .953 26, .188 20. .275 1, .00 48, .47 1SG2051
ATOM 2051 CB PHE 262 87 .069 26, .904 19, .237 1, .00 48, .47 1SG2052
ATOM 2052 CG PHE 262 87 .863 27, .778 18, .325 1, .00 48, .47 1SG2053
ATOM 2053 CDl PHE 262 88 .537 27, .260 17, .242 1, .00 48, .47 1SG2054
ATOM 2054 CD2 PHE 262 87 .910 29, .135 18, .538 1, .00 48, .47 1SG2055
ATOM 2055 CE1 PHE 262 89 .256 28, .073 16, .397 1, .00 48, .47 1SG2056
ATOM 2056 CE2 PHE 262 88. .626 29. .954 17, .698 1, .00 48, .47 1SG2057
ATOM 2057 CZ PHE 262 89 .300 29. .425 16 , .627 1, .00 48. .47 1SG2058
ATOM 2058 C PHE 262 86 .968 25. .509 21, .171 1, .00 48. .47 1SG2059
ATOM 2059 O PHE 262 86 .713 25. .970 22. .282 1, .00 48, .47 1SG2060
ATOM 2060 N LYS 263 86 .358 24. .408 20, .696 1, .00 46. .33 1SG2061
ATOM 2061 CA LYS 263 85 .311 23. .793 21, .455 1, .00 46, .33 1SG2062
ATOM 2062 CB LYS 263 84. .467 22. .769 20, .683 1, .00 46. .33 1SG2063
ATOM 2063 CG LYS 263 83 .146 22. .498 21 .407 1 .00 46 .33 1SG2064
ATOM 2064 CD LYS 263 81 .998 22. .049 20 .503 1 .00 46 .33 1SG2065
ATOM 2065 CE LYS 263 81 .912 20. .543 20 .263 1 .00 46 .33 1SG2066
ATOM 2066 NZ LYS 263 82 .629 20. .185 19 .019 1 .00 46 .33 1SG2067
ATOM 2067 C LYS 263 85 .820 23. .188 22 .721 1 .00 46 .33 1SG2068
ATOM 2068 O LYS 263 85 .096 23. .128 23 .712 1 .00 46 .33 1SG2069
ATOM 2069 N SER 264 87 .074 22. .709 22, .723 1 .00 41, .48 1SG2070
ATOM 2070 CA SER 264 87 .640 22. .114 23, .898 1, .00 41, .48 1SG2071
ATOM 2071 CB SER 264 89 .103 21, .717 23 .652 1, .00 41, .48 1SG2072
ATOM 2072 OG SER 264 89 .744 21. .456 24, .886 1, .00 41, .48 1SG2073
ATOM 2073 C SER 264 87 .615 23. .122 25, .008 1, .00 41, .48 1SG2074
ATOM 2074 O SER 264 87 .456 22. .770 26, .177 1, .00 41, .48 1SG2075
ATOM 2075 N ALA 265 87. .782 24. .413 24, .672 1, .00 35, .43 1SG2076
ATOM 2076 CA ALA 265 87 .789 25. .438 25, .675 1, .00 35, .43 1SG2077
ATOM 2077 CB ALA 265 88, .047 26. .842 25, .100 1, .00 35, .43 1SG2078
ATOM 2078 C ALA 265 86, .453 25. .490 26, .350 1, .00 35, .43 1SG2079
ATOM 2079 O ALA 265 86, .374 25. .583 27, .573 1. .00 35. .43 1SG2080
ATOM 2080 N SER 266 85, .362 25. .415 25. .568 1, .00 31. .32 1SG2081
ATOM 2081 CA SER 266 84, .048 25. .535 26. .131 1, .00 31. .32 1SG2082
ATOM 2082 CB SER 266 82, .937 25. .525 25. .068 1. .00 31. .32 1SG2083
ATOM 2083 OG SER 266 82, .893 24. .263 24. .420 1. .00 31. .32 1SG2084
ATOM 2084 C SER 266 83, .786 24. .396 27. .062 1. .00 31. .32 1SG2085
ATOM 2085 O SER 266 83 .183 24. .574 28. .120 1. .00 31, .32 1SG2086
ATOM 2086 N PHE 267 84 .231 23. .187 26, .682 1, .00 29, .12 1SG2087
ATOM 2087 CA PHE 267 83 .966 22 , .018 27. .464 1. .00 29. .12 1SG2088
ATOM 2088 CB PHE 267 84 .485 20, .743 26. .776 1. .00 29. .12 1SG2089
ATOM 2089 CG PHE 267 83 .870 19, .563 27, .444 1, .00 29. .12 1SG2090
ATOM 2090 CDl PHE 267 82 .628 19. .120 27, .050 1, .00 29. .12 1SG2091
ATOM 2091 CD2 PHE 267 84 .525 18. .897 28, .453 1, .00 29. .12 1SG2092
ATOM 2092 CE1 PHE 267 82, .045 18. .031 27. .654 1. .00 29. .12 1SG2093
ATOM 2093 CE2 PHE 267 83, .946 17. .807 29. .060 1. .00 29. .12 1SG2094
ATOM 2094 CZ PHE 267 82, .705 17. .372 28. .661 1. .00 29. .12 1SG2095
ATOM 2095 C PHE 267 84, .653 22. .147 28. .792 1. .00 29. .12 1SG2096
ATOM 2096 O PHE 267 84, .051 21. .899 29. .836 1. .00 29. .12 1SG2097 ATOM 2097 N ALA 268 85..937 22..554 28,.784 1,.00 29.83 1SG2098
ATOM 2098 CA ALA 268 86, .720 22, .639 29, .987 1. .00 29 .83 1SG2099
ATOM 2099 CB ALA 268 88, .179 23, .048 29, .713 1, .00 29 .83 1SG2100
ATOM 2100 C ALA 268 86, .143 23, .651 30, .932 1, .00 29 .83 1SG2101
ATOM 2101 O ALA 268 86, .087 23, .424 32, .138 1, .00 29 .83 1SG2102
ATOM 2102 N HIS 269 85, .714 24, .808 30, .400 1, .00 32 .29 1SG2103
ATOM 2103 CA HIS 269 85, .174 25, .892 31, .176 1, .00 32 .29 1SG2104
ATOM 2104 NDl HIS 269 82, .968 28, .546 31, .109 1, .00 32 .29 1SG2105
ATOM 2105 CG HIS 269 84, .315 28, .308 30, .965 1, .00 32 .29 1SG2106
ATOM 2106 CB HIS 269 84, .885 27, .107 30, .272 1, .00 32 .29 1SG2107
ATOM 2107 NE2 HIS 269 84, .016 30, .272 32, .036 1. .00 32 .29 1SG2108
ATOM 2108 CD2 HIS 269 84, .944 29, .373 31. .537 1. .00 32 .29 1SG2109
ATOM 2109 CE1 HIS 269 82, .843 29, .731 31. .754 1. .00 3 .29 1SG2110
ATOM 2110 C HIS 269 83, .882 25, .468 31, .823 1. .00 32 .29 1SG2111
ATOM 2111 O HIS 269 83, .625 25. .785 32, .984 1. .00 32 .29 1SG2112
ATOM 2112 N PHE 270 83, .022 24. .762 31, .066 1. .00 32 .55 1SG2113
ATOM 2113 CA PHE 270 81, .728 24. .341 31. .533 1. .00 32 .55 1SG2114
ATOM 2114 CB PHE 270 80, .907 23. .688 30. .407 1. .00 32 .55 1SG2115
ATOM 2115 CG PHE 270 79, .704 23. .054 31, .016 1. .00 32 .55 1SG2116
ATOM 2116 CDl PHE 270 78, .588 23. .797 31, .320 1. .00 32 .55 1SG2117
ATOM 2117 CD2 PHE 270 79, .698 21. .702 31, .277 1. .00 32 .55 1SG2118
ATOM 2118 CE1 PHE 270 77, .485 23. .196 31, .880 1. .00 3 .55 1SG2119
ATOM 2119 CE2 PHE 270 78 .597 21, .097 31 .838 1, .00 32 .55 1SG2120
ATOM 2120 CZ PHE 270 77 .488 21, .847 32, .141 1, .00 32 .55 1SG2121
ATOM 2121 C PHE 270 81 .825 23, .338 32, .648 1, .00 32 .55 1SG2122
ATOM 2122 O PHE 270 81 .205 23, .501 33, .697 1, .00 32 .55 1SG2123
ATOM 2123 N THR 271 82 .644 22 .289 32, .456 1, .00 34 .27 1SG2124
ATOM 2124 CA THR 271 82 .748 21, .192 33, .379 1, .00 34 .27 1SG2125
ATOM 2125 CB THR 271 83 .717 20, .140 32, .921 1, .00 34 .27 1SG2126
ATOM 2126 OGl THR 271 83 .638 18, .999 33, .763 1, .00 34 .27 1SG2127
ATOM 2127 CG2 THR 271 85 .138 20, .729 32, .954 1, .00 34 .27 1SG2128
ATOM 2128 C THR 271 83 .229 21, .690 34, .703 1, .00 34 .27 1SG2129
ATOM 2129 O THR 271 82 .889 21, .133 35, .746 1, .00 34 .27 1SG2130
ATOM 2130 N ALA 272 84, .061 22, .742 34, .684 1, .00 35 .12 1SG2131
ATOM 2131 CA ALA 272 84, .616 23, .320 35, .873 1, .00 35 .12 1SG2132
ATOM 2132 CB ALA 272 85, .565 24. .495 35, .581 1, .00 35 .12 1SG2133
ATOM 2133 C ALA 272 83, .494 23 , .830 36 , .722 1. .00 35 .12 1SG2134
ATOM 2134 O ALA 272 83, .588 23. .812 37, .947 1. .00 35, .12 1SG2135
ATOM 2135 N GLY 273 82 , .403 24. .319 36. .100 1. .00 35, .55 1SG2136
ATOM 2136 ' CA GLY 273 81, .295 24. .824 36. .863 1. .00 35, .55 1SG2137
ATOM 2137 C GLY 273 81, .475 26. .297 37. .019 1. .00 35, .55 1SG2138
ATOM 2138 O GLY 273 80, .816 26. .936 37. .838 1. .00 35, .55 1SG2139
ATOM 2139 N VAL 274 82. .426 26. .858 36. .254 1. .00 37. .23 1SG2140
ATOM 2140 CA VAL 274 82. .725 28. .257 36. .278 1. .00 37. .23 1SG2141
ATOM 2141 CB VAL 274 84. .040 28. .585 35. .639 1. ,00 37. .23 1SG2142
ATOM 2142 CGI VAL 274 83. .972 28. .249 34. .143 1. .00 37, .23 1SG2143
ATOM 2143 CG2 VAL 274 84. .350 30. .059 35. .935 1. .00 37, .23 1SG2144
ATOM 2144 C VAL 274 81. .669 29. .082 35. .609 1. .00 37, .23 1SG2145
ATOM 2145 O VAL 274 81. .412 30. .202 36. .046 1. .00 37, .23 1SG2146
ATOM 2146 N PHE 275 81, .042 28, .586 34. .519 1. .00 37, .26 1SG2147
ATOM 2147 CA PHE 275 80, .120 29, .447 33. .829 1. .00 37, .26 1SG2148
ATOM 2148 CB PHE 275 79. .780 28, .988 32. .399 1. .00 37. .26 1SG2149
ATOM 2149 CG PHE 275 78. .863 30. .010 31. .815 1. .00 37. .26 1SG2150
ATOM 2150 CDl PHE 275 79. .363 31. .198 31. .332 1. .00 37. .26 1SG2151
ATOM 2151 CD2 PHE 275 77. .507 29. .784 31. .740 1. .00 37. .26 1SG2152
ATOM 2152 CE1 PHE 275 78. ,526 32. .146 30. ,792 1. .00 37. .26 1SG2153
ATOM 2153 CE2 PHE 275 76. .665 30. .728 31. ,202 1. .00 37. ,26 1SG2154 ATOM 2154 CZ PHE 275 77.174 31.912 30,.727 1.00 37.26 1SG2155
ATOM 2155 C PHE 275 78 .841 29 .525 34 .601 1 .00 37 .26 1SG2156
ATOM 2156 O PHE 275 77 .858 28. .850 34, .294 1. .00 37 .26 1SG2157
ATOM 2157 N ASN 276 78 .835 30 .399 35 .624 1 .00 36 .99 1SG2158
ATOM 2158 CA ASN 276 77 .679 30 .629 36 .436 1 .00 36 .99 1SG2159
ATOM 2159 CB ASN 276 77 .641 29 .784 37 .722 1 .00 36 .99 1SG2160
ATOM 2160 CG ASN 276 77 .389 28 .330 37 .349 1 .00 36 .99 1SG2161
ATOM 2161 ODl ASN 276 76 .678 28 .033 36 .390 1 .00 36 .99 1SG2162
ATOM 2162 ND2 ASN 276 77 .983 27 .392 38 .135 1 .00 36 .99 1SG2163
ATOM 2163 C ASN 276 77 .766 32 .057 36 .872 1 .00 36 .99 1SG2164
ATOM 2164 O ASN 276 78 .862 32 .593 37 .027 1 .00 36 .99 1SG2165
ATOM 2165 N VAL 277 76, .612 32, .727 37, .064 1. .00 37. .31 1SG2166
ATOM 2166 CA VAL 277 76, .679 34, .087 37, .512 1. .00 37. .31 1SG2167
ATOM 2167 CB VAL 277 76, .769 35, .079 36, .390 1, .00 37. .31 1SG2168
ATOM 2168 CGI VAL 277 76, .717 36, .497 36, .983 1. .00 37. .31 1SG2169
ATOM 2169 CG2 VAL 277 78, .041 34, .786 35, .578 1, .00 37 .31 1SG2170
ATOM 2170 C VAL 277 75, .428 34 , .391 38, .268 1, .00 37. .31 1SG2171
ATOM 2171 O VAL 277 74, .367 33. .836 37, .984 1. .00 37. .31 1SG2172
ATOM 2172 N THR 278 75, .521 35. .293 39, .265 1. .00 38, .44 1SG2173
ATOM 2173 CA THR 278 74, .342 35. .641 39, .997 1, .00 38 .44 1SG2174
ATOM 2174 CB THR 278 74, .438 35, .374 41, .473 1, .00 38 .44 1SG2175
ATOM 2175 OGl THR 278 73, .149 35. .448 42, .060 1, .00 38 .44 1SG2176
ATOM 2176 CG2 THR 278 75, .374 36. .406 42. .125 1 .00 38 .44 1SG2177
ATOM 2177 C THR 278 74, .111 37. .103 39. .787 1, .00 38 .44 1SG2178
ATOM 2178 O THR 278 75, .035 37. .913 39. .865 1. .00 38 .44 1SG2179
ATOM 2179 N LEU 279 72, .857 37. .480 39. .480 1, .00 39 .77 1SG2180
ATOM 2180 CA LEU 279 72, .579 38, .865 39. .254 1, .00 39 .77 1SG2181
ATOM 2181 CB LEU 279 71, .859 39. .134 37. .922 1, .00 39 .77 1SG2182
ATOM 2182 CG LEU 279 72. .710 38. .735 36. .700 1, .00 39 .77 1SG2183
ATOM 2183 CD2 LEU 279 72. .137 39. .301 35. .397 1, .00 39 .77 1SG2184
ATOM 2184 CDl LEU 279 72, .927 37. .216 36, .637 1, .00 39 .77 1SG2185
ATOM 2185 C LEU 279 71, .720 39. .346 40. .376 1, .00 39 .77 1SG2186
ATOM 2186 O LEU 279 70. .777 38. .672 40. .789 1, .00 39 .77 1SG2187
ATOM 2187 N SER 280 72. .052 40. .540 40, .907 1, .00 39 .81 1SG2188
ATOM 2188 CA SER 280 71. .325 41. .109 42, .002 1, .00 39, .81 1SG2189
ATOM 2189 CB SER 280 72. .207 41. .444 43, .219 1, .00 39 .81 1SG2190
ATOM 2190 OG SER 280 71, .417 42. .003 44, .257 1, .00 39, .81 1SG2191
ATOM 2191 C SER 280 70, .731 42 , .395 41, .525 1, .00 39, .81 1SG2192
ATOM 2192 O SER 280 71, .137 42. .947 40, .504 1, .00 39, .81 1SG2193
ATOM 2193 N THR 281 69. .732 42. .894 42. .275 1. .00 40, .57 1SG2194
ATOM 2194 CA THR 281 68. .996 44. .078 41. .935 1. .00 40, .57 1SG2195
ATOM 2195 CB THR 281 67, .912 44. .391 42 , .924 1, .00 40, .57 1SG2196
ATOM 2196 OGl THR 281 67, .096 45. .447 42, .439 1, .00 40, .57 1SG2197
ATOM 2197 CG2 THR 281 68, .563 44. .791 44. .259 1, .00 40. .57 1SG2198
ATOM 2198 C THR 281 69, .926 45. .249 41. .907 1. .00 40. .57 1SG2199
ATOM 2199 O THR 281 69, .739 46. .183 41. .131 1. .00 40. .57 1SG2200
ATOM 2200 N GLU 282 70. .955 45. .226 42. .768 1. .00 40. .69 1SG2201
ATOM 2201 CA GLU 282 71, .882 46. .311 42. .912 1. .00 40. .69 1SG2202
ATOM 2202 CB GLU 282 72. .940 46. ,024 43. .993 1. .00 40. .69 1SG2203
ATOM 2203 CG GLU 282 73. .947 47. .156 44. .197 1. .00 40. .69 1SG2204
ATOM 2204 CD GLU 282 75. .067 47. .010 43. .175 1. .00 40. .69 1SG2205
ATOM 2205 OEl GLU 282 75. .124 45. ,946 42. .503 1. .00 40. .69 1SG2206
ATOM 2206 OE2 GLU 282 75. .882 47. .963 43. .055 1. .00 40. .69 1SG2207
ATOM 2207 C GLU 282 72. .600 46. .568 41. .621 1. .00 40. .69 1SG2208
ATOM 2208 O GLU 282 72. .951 47. .708 41. .319 1. .00 40. .69 1SG2209
ATOM 2209 N GLU 283 72. .845 45. ,514 40. .826 1. .00 41. .80 1SG2210
ATOM 2210 CA GLU 283 73. 628 45. 613 39. 624 1. 00 41. 80 1SG2211 ATOM 2211 CB GLU 283 73..802 44..254 38.,925 1.,00 41.,80 1SG2212
ATOM 2212 CG GLU 283 74. .641 43. .259 39. .731 1. .00 41. .80 1SG2213
ATOM 2213 CD GLU 283 74. .736 41. .966 38. .933 1. .00 41. .80 1SG2214
ATOM 2214 OEl GLU 283 74. .142 41. .910 37. .824 1. .00 41. .80 1SG2215
ATOM 2215 OE2 GLU 283 75. .402 41. .016 39. .424 1. .00 41. .80 1SG2216
ATOM 2216 C GLU 283 73. .023 46. .557 38. ,621 1. .00 41. .80 1SG2217
ATOM 2217 O GLU 283 73, .761 47, .240 37. .913 1. .00 41. .80 1SG2218
ATOM 2218 N ILE 284 71, .681 46, .628 38. .500 1. .00 45. .39 1SG2219
ATOM 2219 CA ILE 284 71. .131 47. .457 37. .455 1. .00 45. .39 1SG2220
ATOM 2220 CB ILE 284 70. .077 46. .761 36. .644 1. .00 45. .39 1SG2221
ATOM 2221 CG2 ILE 284 70. .733 45. .564 35. .936 1. .00 45. .39 1SG2222
ATOM 2222 CGI ILE 284 68. .881 46. .380 37, .532 1, .00 45. .39 1SG2223
ATOM 2223 CDl ILE 284 67. .663 45, .908 36, .741 1, .00 45. .39 1SG2224
ATOM 2224 C ILE 284 70. .510 48, .708 38. .006 1. .00 45. .39 1SG2225
ATOM 2225 O ILE 284 69. .730 48. .682 38. .956 1. .00 45. .39 1SG2226
ATOM 2226 N SER 285 70. .910 49. .860 37. .424 1. .00 49. .06 1SG2227
ATOM 2227 CA SER 285 70. .435 51. .170 37. .790 1, .00 49, .06 1SG2228
ATOM 2228 CB SER 285 71, .427 52. .278 37. .401 1, .00 49, .06 1SG2229
ATOM 2229 OG SER 285 72, .649 52, .111 38. .105 1, .00 49, .06 1SG2230
ATOM 2230 C SER 285 69, .110 51, .536 37. .157 1, .00 49, .06 1SG2231
ATOM 2231 O SER 285 68. .349 52 , .315 37. .728 1, .00 49, .06 1SG2232
ATOM 2232 N ASN 286 68. .803 50 .994 35, .960 1 .00 52 .63 1SG2233
ATOM 2233 CA ASN 286 67. .696 51, .418 35, .130 1 .00 52, .63 1SG2234
ATOM 2234 CB ASN 286 67. .851 50, .899 33, .683 1 .00 52, .63 1SG2235
ATOM 2235 CG ASN 286 67, .074 51, .780 32, .711 1. .00 52, .63 1SG2236
ATOM 2236 ODl ASN 286 65, .958 51, .460 32, .307 1, .00 52 , .63 1SG2237
ATOM 2237 ND2 ASN 286 67, .684 52 .934 32, .326 1 .00 52 .63 1SG2238
ATOM 2238 C ASN 286 66, .353 50, .990 35, .662 1 .00 52, .63 1SG2239
ATOM 2239 O ASN 286 66, .226 50, .491 36, .778 1 .00 52. .63 1SG2240
ATOM 2240 N HIS 287 65, .307 51. .237 34, .835 1, .00 55. .38 1SG2241
ATOM 2241 CA HIS 287 63, .904 51. .044 35, .093 1. .00 55. .38 1SG2242
ATOM 2242 NDl HIS 287 64, .117 53 .392 32, .701 1 .00 55 .38 1SG2243
ATOM 2243 CG HIS 287 63 .138 52. .879 33, .521 1 .00 55, .38 1SG2244
ATOM 2244 CB HIS 287 63, .027 51, .429 33, .889 1, .00 55, .38 1SG2245
ATOM 2245 NE2 HIS 287 62, .834 55, .104 33, .306 1, .00 55, .38 1SG2246
ATOM 2246 CD2 HIS 287 62, .363 53, .938 33. .882 1, .00 55, .38 1SG2247
ATOM 2247 CE1 HIS 287 63, .888 54 .727 32. .605 1 .00 55 .38 1SG2248
ATOM 2248 C HIS 287 63, .604 49. .618 35, .411 1 .00 55, .38 1SG2249
ATOM 2249 0 HIS 287 62, .868 49. .349 36, .360 1, .00 55. .38 1SG2250
ATOM 2250 N PHE 288 64, .144 48, .658 34 , .635 1, .00 57. .94 1SG2251
ATOM 2251 CA PHE 288 63. .860 47, .296 34. .987 1. .00 57. .94 1SG2252
ATOM 2252 CB PHE 288 64. .549 46, .224 34, .111 1 .00 57. .94 1SG2253
ATOM 2253 CG PHE 288 63. .884 46, .108 32, .785 1, .00 57. .94 1SG2254
ATOM 2254 CDl PHE 288 64, .293 46, .886 31, .728 1, .00 57. .94 1SG2255
ATOM 2255 CD2 PHE 288 62. .856 45. .212 32, .599 1, .00 57. .94 1SG2256
ATOM 2256 CE1 PHE 288 63, .679 46. .775 30, .503 1, .00 57. .94 1SG2257
ATOM 2257 CE2 PHE 288 62, .241 45. .098 31, .376 1, .00 57, .94 1SG2258
ATOM 2258 CZ PHE 288 62, .652 45. .881 30, .324 1, .00 57, .94 1SG2259
ATOM 2259 C PHE 288 64 , .431 47. .101 36, .346 1, .00 57. .94 1SG2260
ATOM 2260 0 PHE 288 65. .506 47. .606 36, .660 1, .00 57. .94 1SG2261
ATOM 2261 N VAL 289 63. .696 46. .385 37. .208 1. .00 58. .32 1SG2262
ATOM 2262 CA VAL 289 64, .205 46, .129 38. .516 1 .00 58, .32 1SG2263
ATOM 2263 CB VAL 289 63, .628 47. .040 39. .560 1, .00 58. .32 1SG2264
ATOM 2264 CGI VAL 289 62, .102 47. .079 39. .394 1, .00 58. .32 1SG2265
ATOM 2265 CG2 VAL 289 64. .103 46. .563 40. .943 1. .00 58. .32 1SG2266
ATOM 2266 C VAL 289 63. ,896 44. .710 38. .839 1. .00 58. .32 1SG2267
ATOM 2267 0 VAL 289 62. .825 44. .206 38. .502 1, .00 58. .32 1SG2268 ATOM 2268 N GLN 290 64,.852 44,.014 39,.485 1,.00 63..07 1SG2269
ATOM 2269 CA GLN 290 64, .593 42, .650 39, .814 1, .00 63. .07 1SG2270
ATOM 2270 CB GLN 290 65, .865 41, .785 39, .767 1, .00 63, .07 1SG2271
ATOM 2271 CG GLN 290 66, .973 42, .165 40, .746 1, .00 63, .07 1SG2272
ATOM 2272 CD GLN 290 68, .243 41 .512 40, .213 1, .00 63, .07 1SG2273
ATOM 2273 OEl GLN 290 68, .780 41 .951 39. .197 1, .00 63 .07 1SG2274
ATOM 2274 NE2 GLN 290 68, .736 40 .441 40 .890 1, .00 63 .07 1SG2275
ATOM 2275 C GLN 290 63, .969 42 .643 41 .166 1, .00 63 .07 1SG2276
ATOM 2276 O GLN 290 64, .619 42 .451 42, .191 1 .00 63 .07 1SG2277
ATOM 2277 N ASN 291 62, .646 42 .873 41, .174 1, .00 69 .88 1SG2278
ATOM 2278 CA ASN 291 61, .872 42 .911 42, .376 1, .00 69, .88 1SG2279
ATOM 2279 CB ASN 291 61. .704 44 .323 42, .969 1, .00 69 .88 1SG2280
ATOM 2280 CG ASN 291 61, .010 45 .196 41, .939 1, .00 69 .88 1SG2281
ATOM 2281 ODl ASN 291 61, .089 44 .929 40, .742 1, .00 69 .88 1SG2282
ATOM 2282 ND2 ASN 291 60 .319 46 .270 42, .408 1, .00 69 .88 1SG2283
ATOM 2283 C ASN 291 60, .522 42 .353 42, .052 1, .00 69 .88 1SG2284
ATOM 2284 O ASN 291 60, .122 42 .298 40, .888 1, .00 69 .88 1SG2285
ATOM 2285 N SER 292 59 .800 41 .893 43, .093 1, .00 76 .78 1SG2286
ATOM 2286 CA SER 292 58, .495 41 .314 42, .942 1, .00 76 .78 1SG2287
ATOM 2287 CB SER 292 57 .918 40 .820 44, .276 1, .00 76 .78 1SG2288
ATOM 2288 OG SER 292 56 .633 40 .261 44, .063 1, .00 76 .78 1SG2289
ATOM 2289 C SER 292 57, .575 42 .365 42, .420 1. .00 76 .78 1SG2290
ATOM 2290 O SER 292 56, .788 42 .120 41, .508 1, .00 76 .78 1SG2291
ATOM 2291 N GLN 293 57, .679 43 .595 42, .962 1, .00 82 .82 1SG2292
ATOM 2292 CA GLN 293 56, .904 44 .664 42 .400 1. .00 82 .82 1SG2293
ATOM 2293 CB GLN 293 56, .975 45 .984 43, .184 1, .00 82 .82 1SG2294
ATOM 2294 CG GLN 293 56, .241 45 .926 44, .523 1, .00 82 .82 1SG2295
ATOM 2295 CD GLN 293 56, .934 44 .874 45, .371 1. .00 82 .82 1SG2296
ATOM 2296 OEl GLN 293 56. .284 44 .086 46, .055 1, .00 82 .82 1SG2297
ATOM 2297 NE2 GLN 293 58. .293 44 .859 45, .320 1, .00 82 .82 1SG2298
ATOM 2298 C GLN 293 57. .587 44 .866 41, .098 1. .00 82 .82 1SG2299
ATOM 2299 O GLN 293 58. .639 44, .318 40, .881 1, .00 82 .82 1SG2300
ATOM 2300 N GLY 294 57, .057 45 .552 40, .107 1, .00 79 .74 1SG2301
ATOM 2301 CA GLY 294 57, .901 45 .616 38, .946 1, .00 79 .74 1SG2302
ATOM 2302 C GLY 294 57, .578 44, .407 38, .125 1, .00 79, .74 1SG2303
ATOM 2303 O GLY 294 56, .985 44 .511 37, .058 1, .00 79 .74 1SG2304
ATOM 2304 N LEU 295 57, .921 43 .210 38, .642 1, .00 72, .01 1SG2305
ATOM 2305 CA LEU 295 57, .595 41 .957 38, .037 1, .00 72, .01 1SG2306
ATOM 2306 CB LEU 295 58, .207 40 .729 38, .730 1, .00 72, .01 1SG2307
ATOM 2307 CG LEU 295 57, .829 39. .411 38, .025 1, .00 72 , .01 1SG2308
ATOM 2308 CD2 LEU 295 58, .274 38. .185 38, .841 1, .00 72 , .01 1SG2309
ATOM 2309 CDl LEU 295 58, .356 39, .379 36, .584 1, .00 72 , .01 1SG2310
ATOM 2310 C LEU 295 56, .124 41, .880 38, .173 1. .00 72 , .01 1SG2311
ATOM 2311 O LEU 295 55, .438 41, .143 37, .468 1. .00 72. .01 1SG2312
ATOM 2312 N GLY 296 55, .612 42 , .648 39. .146 1. .00 62. .05 1SG2313
ATOM 2313 CA GLY 296 54, .212 42 , .636 39. .441 1. .00 62. .05 1SG2314
ATOM 2314 C GLY 296 53, .417 43, .032 38. .241 1. .00 62. .05 1SG2315
ATOM 2315 O GLY 296 52 , .302 42. .544 38, .055 1. .00 62. .05 1SG2316
ATOM 2316 N ASN 297 53, .926 43 , .958 37, .405 1, .00 56. .96 1SG2317
ATOM 2317 CA ASN 297 53, .058 44. .337 36. .322 1. .00 56. .96 1SG2318
ATOM 2318 CB ASN 297 53. .586 45. .492 35. .438 1. .00 56. .96 1SG2319
ATOM 2319 CG ASN 297 54. .726 45. .040 34. .532 1. .00 56. .96 1SG2320
ATOM 2320 ODl ASN 297 55. .646 44. .324 34. .921 1. .00 56. .96 1SG2321
ATOM 2321 ND2 ASN 297 54. .657 45. .479 33. .246 1. .00 56. .96 1SG2322
ATOM 2322 C ASN 297 52. .803 43. .147 35. .439 1. .00 56. .96 1SG2323
ATOM 2323 O ASN 297 51. .669 42. .903 35. .026 1. .00 56. .96 1SG2324
ATOM 2324 N VAL 298 53. ,873 42. .407 35. .093 1. .00 59. .93 1SG2325 ATOM 2325 CA VAL 298 53..792 41,.261 34,.230 1..00 59..93 1SG2326
ATOM 2326 CB VAL 298 55. .123 40, .923 33, .625 1. .00 59. .93 1SG2327
ATOM 2327 CGI VAL 298 54. .974 39 .635 32 .799 1. .00 59. .93 1SG2328
ATOM 2328 CG2 VAL 298 55, .616 42, .134 32, .815 1. .00 59. .93 1SG2329
ATOM 2329 C VAL 298 53, .289 40, .001 34 , .883 1. .00 59. ,93 1SG2330
ATOM 2330 O VAL 298 52 .436 39 .319 34 .314 1. .00 59. .93 1SG2331
ATOM 2331 N LEU 299 53, .823 39 .624 36 .073 1. .00 65. .98 1SG2332
ATOM 2332 CA LEU 299 53, .440 38, .331 36, .576 1. .00 65. .98 1SG2333
ATOM 2333 CB LEU 299 54, .553 37 .281 36 .416 1. .00 65, .98 1SG2334
ATOM 2334 CG LEU 299 54, .987 37 .043 34, .959 1, .00 65. .98 1SG2335
ATOM 2335 CD2 LEU 299 53, .780 36, .733 34, .064 1. .00 65. .98 1SG2336
ATOM 2336 CDl LEU 299 56, .089 35 .976 34 .870 1. .00 65, .98 1SG2337
ATOM 2337 C LEU 299 53, .139 38 .357 38, .043 1. .00 65. .98 1SG2338
ATOM 2338 O LEU 299 54, .025 38, .098 38. .857 1. .00 65. .98 1SG2339
ATOM 2339 N SER 300 51. .869 38 .588 38 .436 1. .00 71, .12 1SG2340
ATOM 2340 CA SER 300 51 .607 38 .563 39, .848 1. .00 71, .12 1SG2341
ATOM 2341 CB SER 300 51, .250 39, .933 40, .434 1. .00 71. .12 1SG2342
ATOM 2342 OG SER 300 52 .371 40 .792 40 .366 1. .00 71, .12 1SG2343
ATOM 2343 C SER 300 50, .417 37 .714 40 .158 1, .00 71, .12 1SG2344
ATOM 2344 O SER 300 49, .282 38 .134 39, .934 1, .00 71. .12 1SG2345
ATOM 2345 N ARG 301 50 .629 36 .481 40 .665 1. .00 69. .34 1SG2346
ATOM 2346 CA ARG 301 51, .913 35 .850 40 .743 1, .00 69. .34 1SG2347
ATOM 2347 CB ARG 301 52, .633 35, .783 39, .388 1. .00 69. .34 1SG2348
ATOM 2348 CG ARG 301 51 .796 35 .084 38 .315 1. .00 69. .34 1SG2349
ATOM 2349 CD ARG 301 50, .612 35 .920 37, .824 1. .00 69, .34 1SG2350
ATOM 2350 NE ARG 301 49. .853 35, .103 36, .837 1, .00 69. .34 1SG2351
ATOM 2351 CZ ARG 301 48, .864 34 .267 37 .268 1. .00 69. .34 1SG2352
ATOM 2352 NHl ARG 301 48, .579 34 .179 38, .600 1. .00 69. .34 1SG2353
ATOM 2353 NH2 ARG 301 48, .157 33, .524 36, .368 1. .00 69. .34 1SG2354
ATOM 2354 C ARG 301 52, .844 36 .423 41 .769 1. .00 69. .34 1SG2355
ATOM 2355 O ARG 301 52, .508 36 .571 42, .942 1. .00 69. .34 1SG2356
ATOM 2356 N ILE 302 54, .073 36, .758 41. .313 1. .00 59. .78 1SG2357
ATOM 2357 CA ILE 302 55 .172 37 .130 42. .161 1. .00 59. .78 1SG2358
ATOM 2358 CB ILE 302 56, .387 37, .589 41. .406 1. .00 59. .78 1SG2359
ATOM 2359 CG2 ILE 302 56. .036 38. .872 40. .635 1. .00 59. .78 1SG2360
ATOM 2360 CGI ILE 302 57. .569 37. .741 42, .381 1. .00 59. .78 1SG2361
ATOM 2361 CDl ILE 302 58, .927 37. .902 41, .700 1. .00 59. .78 1SG2362
ATOM 2362 C ILE 302 54. .797 38. .220 43. .105 1. .00 59. .78 1SG2363
ATOM 2363 O ILE 302 55. .154 38. .157 44. .280 1. .00 59, .78 1SG2364
ATOM 2364 N ALA 303 54, .089 39, .261 42. .646 1. .00 48. .81 1SG2365
ATOM 2365 CA ALA 303 53. .747 40. .268 43. .602 1. .00 48. ,81 1SG2366
ATOM 2366 CB ALA 303 53. .002 41, .466 42. .991 1. .00 48. .81 1SG2367
ATOM 2367 C ALA 303 52. .847 39, .653 44. .621 1. .00 48. .81 1SG2368
ATOM 2368 O ALA 303 53. .045 39. .851 45. ,815 1. .00 48. .81 1SG2369
ATOM 2369 N GLU 304 51. .842 38. .874 44. .173 1. .00 41. .98 1SG2370
ATOM 2370 CA GLU 304 50. .861 38, .332 45. .073 1. .00 41. .98 1SG2371
ATOM 2371 CB GLU 304 49. .721 37. .610 44. .331 1. ,00 41. .98 1SG2372
ATOM 2372 CG GLU 304 48, .857 38, .546 43. .482 1. .00 41. .98 1SG2373
ATOM 2373 CD GLU 304 47. .782 37, .707 42. .805 1. ,00 41. .98 1SG2374
ATOM 2374 OEl GLU 304 47. .763 36. .469 43. ,040 1. ,00 41. ,98 1SG2375
ATOM 2375 OE2 GLU 304 46. .965 38. .293 42. .046 1. .00 41. ,98 1SG2376
ATOM 2376 C GLU 304 51. .449 37. .342 46. .035 1. .00 41. ,98 1SG2377
ATOM 2377 O GLU 304 51. .263 37. .467 47. ,244 1. ,00 41. ,98 1SG2378
ATOM 2378 N ILE 305 52. .174 36. .325 45. .529 1. ,00 39. .99 1SG2379
ATOM 2379 CA ILE 305 52. .682 35. .303 46. ,399 1. ,00 39. .99 1SG2380
ATOM 2380 CB ILE 305 53. .329 34. .177 45. ,647 1. ,00 39. 99 1SG2381
ATOM 2381 CG2 ILE 305 53. ,967 33. .228 46. ,675 1. ,00 39. ,99 1SG2382 ATOM 2382 CGI ILE 305 52..307 33..490 44.,725 1..00 39..99 1SG2383
ATOM 2383 CDl ILE 305 51. .124 32. .878 45. .473 1. .00 39. .99 1SG2384
ATOM 2384 C ILE 305 53. .720 35. .886 47. ,295 1. .00 39, .99 1SG2385
ATOM 2385 0 ILE 305 53. .665 35. .726 48. .513 1. .00 39, .99 1SG2386
ATOM 2386 N TYR 306 54. .700 36. .598 46. .711 1. .00 44 .42 1SG2387
ATOM 2387 CA TYR 306 55. .698 37. .178 47. .551 1. ,00 44. .42 1SG2388
ATOM 2388 CB TYR 306 57. .133 36. .815 47. .136 1. .00 44. .42 1SG2389
ATOM 2389 CG TYR 306 57. .257 35. .378 47. .507 1. ,00 44, .42 1SG2390
ATOM 2390 CDl TYR 306 57. .626 35. .031 48. .786 1. .00 44, .42 1SG2391
ATOM 2391 CD2 TYR 306 56. .986 34. .381 46. .598 1. .00 44 .42 1SG2392
ATOM 2392 CE1 TYR 306 57. .733 33. .712 49. .155 1. .00 44, .42 1SG2393
ATOM 2393 CE2 TYR 306 57. .091 33. .058 46. .961 1. .00 44 .42 1SG2394
ATOM 2394 CZ TYR 306 57. .465 32. .723 48. .241 1. .00 44, .42 1SG2395
ATOM 2395 OH TYR 306 57. .572 31. .369 48. .623 1. .00 44 .42 1SG2396
ATOM 2396 C TYR 306 55, .501 38. .650 47. .511 1. .00 44 .42 1SG2397
ATOM 2397 O TYR 306 56. .046 39. .348 46. .655 1. .00 44 .42 1SG2398
ATOM 2398 N ILE 307 54. .702 39, .145 48. .477 1. .00 50 .84 1SG2399
ATOM 2399 CA ILE 307 54. .383 40. .536 48. .550 1. .00 50 .84 1SG2400
ATOM 2400 CB ILE 307 53. .016 40. .780 49. .152 1. .00 50 .84 1SG2401
ATOM 2401 CG2 ILE 307 51, .921 40. .159 48. .275 1, .00 50 .84 1SG2402
ATOM 2402 CGI ILE 307 52. .968 40. .242 50. .594 1. .00 50 .84 1SG2403
ATOM 2403 CDl ILE 307 51. .741 40. .707 51, .376 1. .00 50 .84 1SG2404
ATOM 2404 C ILE 307 55. .314 41. .147 49. .536 1. .00 50 .84 1SG2405
ATOM 2405 O ILE 307 54. .957 42, .082 50. .244 1. .00 50 .84 1SG2406
ATOM 2406 N LEU 308 56. .572 40, .712 49. .611 1. .00 54 .47 1SG2407
ATOM 2407 CA LEU 308 57. .263 41, .408 50. .644 1. .00 54 .47 1SG2408
ATOM 2408 CB LEU 308 58. .281 40, .533 51. .390 1. .00 54 .47 1SG2409
ATOM 2409 CG LEU 308 57. .634 39. .372 52. .169 1. .00 54, .47 1SG2410
ATOM 2410 CD2 LEU 308 58, .650 38. .688 53. .097 1. .00 54 .47 1SG2411
ATOM 2411 CDl LEU 308 56, .931 38 .386 51. .223 1. .00 54 .47 1SG2412
ATOM 2412 C LEU 308 58. .003 42. .516 49. .996 1. .00 54 .47 1SG2413
ATOM 2413 O LEU 308 58, .982 42 .992 50. .571 1. .00 54 .47 1SG2414
ATOM 2414 N SER 309 57. .505 42. .968 48. .814 1. .00 57 .77 1SG2415
ATOM 2415 CA SER 309 58. .170 43, .981 48. .043 1. .00 57 .77 1SG2416
ATOM 2416 CB SER 309 58. .134 45 .394 48. .662 1, .00 57 .77 1SG2417
ATOM 2417 OG SER 309 58. .922 45, .459 49. .840 1. .00 57, .77 1SG2418
ATOM 2418 C SER 309 59. .570 43 .493 47, .977 1, .00 57 .77 1SG2419
ATOM 2419 O SER 309 60. .533 44, .230 48. .180 1. .00 57, .77 1SG2420
ATOM 2420 N GLN 310 59. .679 42, .176 47, .742 1. .00 56 .76 1SG2421
ATOM 2421 CA GLN 310 60. .933 41 .503 47, .818 1. .00 56 .76 1SG2422
ATOM 2422 CB GLN 310 60. .806 39, .984 48, .025 1. .00 56, .76 1SG2423
ATOM 2423 CG GLN 310 60. .233 39, .600 49, .387 1. .00 56 .76 1SG2424
ATOM 2424 CD GLN 310 61. .240 40, .026 50. .444 1. .00 56, .76 1SG2425
ATOM 2425 OEl GLN 310 62. .231 40, .690 50. .143 1. .00 56, .76 1SG2426
ATOM 2426 NE2 GLN 310 60. .984 39 .635 51, .720 1. .00 56. .76 1SG2427
ATOM 2427 C GLN 310 61. .720 41, .695 46. .577 1. .00 56, .76 1SG2428
ATOM 2428 O GLN 310 61. .221 41, .990 45. .491 1. .00 56, .76 1SG2429
ATOM 2429 N PRO 311 62. .993 41, .574 46. .817 1. .00 53. .23 1SG2430
ATOM 2430 CA PRO 311 63. .939 41, .620 45. .745 1. .00 53. .23 1SG2431
ATOM 2431 CD PRO 311 63. .538 42 , .135 48, .044 1. .00 53. .23 1SG2432
ATOM 2432 CB PRO 311 65. .288 41, .948 46. .380 1. .00 53. .23 1SG2433
ATOM 2433 CG PRO 311 64. .911 42, .709 47. .662 1. .00 53. .23 1SG2434
ATOM 2434 C PRO 311 63. .923 40. .298 45. .053 1. ,00 53. .23 1SG2435
ATOM 2435 O PRO 311 63. .444 39. .322 45. .630 1. ,00 53. .23 1SG2436
ATOM 2436 N PHE 312 64. .428 40. .256 43. .811 1. .00 49. .71 1SG2437
ATOM 2437 CA PHE 312 64. .502 39. .051 43. .043 1. .00 49. .71 1SG2438
ATOM 2438 CB PHE 312 63. .668 39, .127 41. .748 1. .00 49. .71 1SG2439 ATOM 2439 CG PHE 312 64,.358 38,.365 40,.670 1,.00 49,.71 1SG2440
ATOM 2440 CDl PHE 312 64. .550 37, .005 40, .719 1, .00 49, .71 1SG2441
ATOM 2441 CD2 PHE 312 64, .793 39, .051 39, .561 1, .00 49, .71 1SG2442
ATOM 2442 CE1 PHE 312 65, .202 36, .366 39, .689 1, .00 49 .71 1SG2443
ATOM 2443 CE2 PHE 312 65, .438 38, .419 38, .528 1, .00 49 .71 1SG2444
ATOM 2444 CZ PHE 312 65, .637 37, .066 38, .592 1, .00 49, .71 1SG2445
ATOM 2445 C PHE 312 65, .933 38, .821 42, .702 1, .00 49 .71 1SG2446
ATOM 2446 O PHE 312 66. .652 39, .766 42, .388 1, .00 49 .71 1SG2447
ATOM 2447 N MET 313 66. .388 37, .552 42, .788 1, .00 44 .51 1SG2448
ATOM 2448 CA MET 313 67. .745 37, .226 42, .456 1, .00 44. .51 1SG2449
ATOM 2449 CB MET 313 68, .541 36, .638 43, .633 1. .00 44. .51 1SG2450
ATOM 2450 CG MET 313 70, .006 36, .349 43, .300 1, .00 44 .51 1SG2451
ATOM 2451 SD MET 313 70. .970 35, .659 44, .679 1, .00 44 .51 1SG2452
ATOM 2452 CE MET 313 70. .106 34, .063 44, .697 1, .00 44 .51 1SG2453
ATOM 2453 C MET 313 67. .704 36, .193 41, .372 1, .00 44 .51 1SG2454
ATOM 2454 O MET 313 66. .945 35, .228 41, .460 1, .00 44 .51 1SG2455
ATOM 2455 N VAL 314 68. .528 36, .373 40, .315 1, .00 40 .70 1SG2456
ATOM 2456 CA VAL 314 68. .508 35, .463 39, .201 1, .00 40 .70 1SG2457
ATOM 2457 CB VAL 314 68. .339 36, .143 37, .875 1, .00 40 .70 1SG2458
ATOM 2458 CGI VAL 314 69. .553 37, .056 37, .636 1, .00 40 .70 1SG2459
ATOM 2459 CG2 VAL 314 68, .152 35, .065 36, .794 1, .00 40 .70 1SG2460
ATOM 2460 C VAL 314 69, .815 34, .738 39, .114 1, .00 40 .70 1SG2461
ATOM 2461 0 VAL 314 70, .880 35, .309 39, .344 1, .00 40 .70 1SG2462
ATOM 2462 N ARG 315 69. .760 33 .437 38, .761 1, .00 37 .28 1SG2463
ATOM 2463 CA ARG 315 70, .966 32 .674 38, .636 1, .00 37 .28 1SG2464
ATOM 2464 CB ARG 315 70, .975 31, .394 39, .491 1, .00 37 .28 1SG2465
ATOM 2465 CG ARG 315 69. .841 30, .423 39, .157 1, .00 37 .28 1SG2466
ATOM 2466 CD ARG 315 69, .839 29, .167 40, .031 1, .00 37, .28 1SG2467
ATOM 2467 NE ARG 315 71, .097 28 .421 39 .746 1, .00 37 .28 1SG2468
ATOM 2468 CZ ARG 315 71, .473 27, .385 40, .552 1, .00 37 .28 1SG2469
ATOM 2469 NHl ARG 315 70, .699 27, .034 41, .620 1, .00 37 .28 1SG2470
ATOM 2470 NH2 ARG 315 72, .624 26, .700 40, .289 1, .00 37 .28 1SG2471
ATOM 2471 C ARG 315 71, .117 32, .270 37, .202 1, .00 37 .28 1SG2472
ATOM 2472 O ARG 315 70, .184 31, .760 36, .583 1, .00 37, .28 1SG2473
ATOM 2473 N ILE 316 72, .317 32, .503 36, .635 1, .00 33 .35 1SG2474
ATOM 2474 CA ILE 316 72, .567 32, .164 35, .263 1, .00 33, .35 1SG2475
ATOM 2475 CB ILE 316 73 , .030 33, .335 34, .440 1, .00 33, .35 1SG2476
ATOM 2476 CG2 ILE 316 71, .909 34, .388 34, .444 1, .00 33, .35 1SG2477
ATOM 2477 CGI ILE 316 74, .371 33, .878 34, .962 1, .00 33, .35 1SG2478
ATOM 2478 CDl ILE 316 75. .061 34, .839 33, .997 1. .00 33, .35 1SG2479
ATOM 2479 C ILE 316 73. .650 31, .123 35, .230 1. .00 33, .35 1SG2480
ATOM 2480 O ILE 316 74, .720 31. .298 35, .811 1, .00 33. .35 1SG2481
ATOM 2481 N MET 317 73 , .388 29, .991 34. .549 1. .00 30. .03 1SG2482
ATOM 2482 CA MET 317 74 , .372 28, .951 34. .460 1. .00 30. .03 1SG2483
ATOM 2483 CB MET 317 74. .120 27, .781 35. .428 1. .00 30. .03 1SG2484
ATOM 2484 CG MET 317 72. .845 26. .993 35. .122 1. .00 30. .03 1SG2485
ATOM 2485 SD MET 317 72. .530 25. .606 36. .255 1. .00 30. .03 1SG2486
ATOM 2486 CE MET 317 73. .869 24, .563 35. .609 1. .00 30. .03 1SG2487
ATOM 2487 C MET 317 74. .323 28, .397 33. .070 1. .00 30. .03 1SG2488
ATOM 2488 O MET 317 73. .335 28, .569 32. .358 1. .00 30. .03 1SG2489
ATOM 2489 N ALA 318 75. .407 27, .720 32. .638 1. ,00 28. .34 1SG2490
ATOM 2490 CA ALA 318 75. .425 27. .162 31. .317 1. ,00 28. .34 1SG2491
ATOM 2491 CB ALA 318 76. .831 27. .106 30. ,693 1. ,00 28. .34 1SG2492
ATOM 2492 C ALA 318 74. ,920 25. .761 31. .421 1. ,00 28. ,34 1SG2493
ATOM 2493 O ALA 318 75. .419 24. ,969 32. .218 1. ,00 28. ,34 1SG2494
ATOM 2494 N THR 319 73. .873 25. .440 30. ,635 1. ,00 30. ,26 1SG2495
ATOM 2495 CA THR 319 73. ,287 24. .130 30. ,658 1. ,00 30. ,26 1SG2496 ATOM 2496 CB THR 319 72..026 24..046 29.,849 1..00 30..26 1SG2497
ATOM 2497 OGl THR 319 72. .307 24, .276 28. .476 1. .00 30. .26 1SG2498
ATOM 2498 CG2 THR 319 71. .040 25. .105 30. .363 1. .00 30. .26 1SG2499
ATOM 2499 C THR 319 74. .229 23. .125 30. .071 1. .00 30. .26 1SG2500
ATOM 2500 O THR 319 74. .462 22. .065 30. .651 1. ,00 30. .26 1SG2501
ATOM 2501 N GLU 320 74, .802 23. .443 28. .892 1. .00 34. .19 1SG2502
ATOM 2502 CA GLU 320 75 .638 22. .502 28. .200 1. .00 34. .19 1SG2503
ATOM 2503 CB GLU 320 74, .916 21. .876 26. .989 1. .00 34. .19 1SG2504
ATOM 2504 CG GLU 320 75. .653 20. .717 26. .316 1. .00 34. .19 1SG2505
ATOM 2505 CD GLU 320 74. .769 20. .188 25. .195 1. .00 34. .19 1SG2506
ATOM 2506 OEl GLU 320 73. .658 20. .750 25. .002 1. .00 34. .19 1SG2507
ATOM 2507 OE2 GLU 320 75, .191 19. .213 24. .519 1. .00 34. .19 1SG2508
ATOM 2508 C GLU 320 76, .839 23. .245 27, .700 1. .00 34. .19 1SG2509
ATOM 2509 O GLU 320 76, .879 24, .473 27. .752 1. .00 34. .19 1SG2510
ATOM 2510 N PRO 321 77, .841 22. .536 27. .243 1. .00 39. .15 1SG2511
ATOM 2511 CA PRO 321 79, .002 23, .216 26. .740 1. .00 39. .15 1SG2512
ATOM 2512 CD PRO 321 78, .195 21, .266 27. .860 1, .00 39, .15 1SG2513
ATOM 2513 CB PRO 321 80 .083 22, .149 26, .597 1. .00 39, .15 1SG2514
ATOM 2514 CG PRO 321 79 .721 21, .135 27, .699 1, .00 39, .15 1SG2515
ATOM 2515 C PRO 321 78 .690 23, .977 25, .494 1. .00 39, .15 1SG2516
ATOM 2516 O PRO 321 77, .994 23, .458 24, .623 1. .00 39 .15 1SG2517
ATOM 2517 N PRO 322 79 .212 25 .165 25, .391 1, .00 43, .84 1SG2518
ATOM 2518 CA PRO 322 78 .936 25, .988 24, .247 1. .00 43 .84 1SG2519
ATOM 2519 CD PRO 322 79, .498 25 .955 26, .578 1, .00 43, .84 1SG2520
ATOM 2520 CB PRO 322 79 .440 27, .378 24, .614 1, .00 43 .84 1SG2521
ATOM 2521 CG PRO 322 79, .322 27 .419 26 .148 1, .00 43, .84 1SG2522
ATOM 2522 C PRO 322 79 .576 25 .424 23, .017 1, .00 43 .84 1SG2523
ATOM 2523 O PRO 322 80, .653 24, .838 23 .110 1, .00 43, .84 1SG2524
ATOM 2524 N ILE 323 78 .941 25 .603 21 .846 1, .00 44 .36 1SG2525
ATOM 2525 CA ILE 323 79, .481 25, .061 20 .634 1, .00 44, .36 1SG2526
ATOM 2526 CB ILE 323 78 .485 24. .264 19 .840 1, .00 44, .36 1SG2527
ATOM 2527 CG2 ILE 323 79 .149 23, .878 18 .507 1 .00 44 .36 1SG2528
ATOM 2528 CGI ILE 323 77 .980 23 .059 20 .655 1, .00 44, .36 1SG2529
ATOM 2529 CDl ILE 323 79 .072 22, .067 21 .047 1 .00 44, .36 1SG2530
ATOM 2530 C ILE 323 79, .902 26 .209 19 .777 1, .00 44, .36 1SG2531
ATOM 2531 O ILE 323 79 .250 27, .251 19, .763 1, .00 44, .36 1SG2532
ATOM 2532 N ILE 324 81, .041 26 .053 19 .071 1, .00 45. .40 1SG2533
ATOM 2533 CA ILE 324 81 .538 27 .096 18, .222 1, .00 45, .40 1SG2534
ATOM 2534 CB ILE 324 82 .909 27 .547 18 .626 1, .00 45. .40 1SG2535
ATOM 2535 CG2 ILE 324 83 .244 28 .809 17, .815 1. .00 45. .40 1SG2536
ATOM 2536 CGI ILE 324 82 .987 27, .752 20 .148 1, .00 45. .40 1SG2537
ATOM 2537 CDl ILE 324 81 .935 28 .692 20 .715 1. .00 45. .40 1SG2538
ATOM 2538 C ILE 324 81. .727 26, .463 16 .879 1. .00 45. .40 1SG2539
ATOM 2539 O ILE 324 82 .412 25 .448 16, .761 1. .00 45. .40 1SG2540
ATOM 2540 N ASN 325 81 .130 27, .030 15 .815 1. .00 49. .29 1SG2541
ATOM 2541 CA ASN 325 81 .371 26. .419 14, .543 1. .00 49. .29 1SG2542
ATOM 2542 CB ASN 325 80 .143 25, .728 13, .909 1, .00 49. .29 1SG2543
ATOM 2543 CG ASN 325 78. .918 26 .616 13 .998 1. .00 49. .29 1SG2544
ATOM 2544 ODl ASN 325 78 .574 27, .074 15, .086 1, .00 49. .29 1SG2545
ATOM 2545 ND2 ASN 325 78. .220 26 .820 12 .850 1, .00 49. .29 1SG2546
ATOM 2546 C ASN 325 82 .034 27, .390 13 .628 1. .00 49, .29 1SG2547
ATOM 2547 O ASN 325 81. .662 28, .560 13 .549 1. .00 49. .29 1SG2548
ATOM 2548 N LEU 326 83 .088 26, .919 12 .929 1. .00 53. .49 1SG2549
ATOM 2549 CA LEU 326 83 .810 27, .834 12 .097 1, .00 53. .49 1SG2550
ATOM 2550 CB LEU 326 85, .315 27, .882 12 .404 1. .00 53. .49 1SG2551
ATOM 2551 CG LEU 326 86, .005 29. .063 11. .713 1. .00 53. .49 1SG2552
ATOM 2552 CD2 LEU 326 87, .506 29, .116 12, .034 1. .00 53. ,49 1SG2553 ATOM 2553 CDl LEU 326 85,.300 30,.375 12,.094 1..00 53,.49 1SG2554
ATOM 2554 C LEU 326 83. .597 27, .473 10, .661 1. .00 53, .49 1SG2555
ATOM 2555 O LEU 326 83. .779 26, .327 10, .254 1. .00 53, .49 1SG2556
ATOM 2556 N GLN 327 83. .173 28, .469 9. .855 1. .00 61, .24 1SG2557
ATOM 2557 CA GLN 327 82. .958 28. .261 8, .452 1. .00 61, .24 1SG2558
ATOM 2558 CB GLN 327 81. .484 28. .075 8, .052 1. .00 61, .24 1SG2559
ATOM 2559 CG GLN 327 80. .801 26. .854 8. .673 1. .00 61, .24 1SG2560
ATOM 2560 CD GLN 327 79. .942 27. .311 9. .847 1. ,00 61, .24 1SG2561
ATOM 2561 OEl GLN 327 79, .151 26 .532 10. .376 1. .00 61 .24 1SG2562
ATOM 2562 NE2 GLN 327 80, .080 28. .601 10. .253 1. .00 61 .24 1SG2563
ATOM 2563 C GLN 327 83 , .400 29, .511 7. .777 1. .00 61, .24 1SG2564
ATOM 2564 o GLN 327 83, .404 30, .567 8, .405 1. .00 61, .24 1SG2565
ATOM 2565 N PRO 328 83, .795 29, .416 6. .530 1. .00 66, .68 1SG2566
ATOM 2566 CA PRO 328 84, .206 30, .578 5, .792 1. .00 66, .68 1SG2567
ATOM 2567 CD PRO 328 83. .324 28, .357 5. .654 1. .00 66, .68 1SG2568
ATOM 2568 CB PRO 328 84. .412 30 .099 4, .359 1, .00 66 .68 1SG2569
ATOM 2569 CG PRO 328 83, .390 28 .953 4, .236 1. .00 66 .68 1SG2570
ATOM 2570 C PRO 328 83, .053 31 .510 5, .881 1. .00 66 .68 1SG2571
ATOM 2571 O PRO 328 81, .946 31, .094 5, .572 1. .00 66 .68 1SG2572
ATOM 2572 N GLY 329 83, .266 32, .768 6, .278 1. .00 65 .71 1SG2573
ATOM 2573 CA GLY 329 82 , .154 33. .653 6, .422 1. .00 65 .71 1SG2574
ATOM 2574 C GLY 329 82. .108 34. .085 7, .849 1. .00 65 .71 1SG2575
ATOM 2575 O GLY 329 81. .959 35, .277 8, .110 1. .00 65. .71 1SG2576
ATOM 2576 N ASN 330 82. .243 33 .146 8, .815 1. .00 62 .90 1SG2577
ATOM 2577 CA ASN 330 82. .254 33 .618 10, .171 1. .00 62 .90 1SG2578
ATOM 2578 CB ASN 330 81. .032 34 .475 10. .554 1. .00 62 .90 1SG2579
ATOM 2579 CG ASN 330 79, .793 33, .595 10. .476 1. .00 62. .90 1SG2580
ATOM 2580 ODl ASN 330 79. .589 32, .864 9, .508 1. .00 62, .90 1SG2581
ATOM 2581 ND2 ASN 330 78. .940 33, .661 11. .533 1. .00 62, .90 1SG2582
ATOM 2582 C ASN 330 82. .258 32, .486 11. .149 1. .00 62. .90 1SG2583
ATOM 2583 O ASN 330 82. .061 31 .323 10 .802 1. .00 62 .90 1SG2584
ATOM 2584 N PHE 331 82. .470 32 .853 12 .432 1, .00 56 .26 1SG2585
ATOM 2585 CA PHE 331 82, .456 31 .959 13. .557 1. .00 56 .26 1SG2586
ATOM 2586 CB PHE 331 83 , .425 32 .368 14, .683 1. .00 56, .26 1SG2587
ATOM 2587 CG PHE 331 84, .837 32, .402 14, .222 1. .00 56, .26 1SG2588
ATOM 2588 CDl PHE 331 85, .243 33 .343 13, .304 1. .00 56, .26 1SG2589
ATOM 2589 CD2 PHE 331 85, .763 31, .534 14, .757 1. .00 56, .26 1SG2590
ATOM 2590 CE1 PHE 331 86. .552 33, .388 12. .888 1. .00 56, .26 1SG2591
ATOM 2591 CE2 PHE 331 87. .073 31 .577 14 .343 1, .00 56. .26 1SG2592
ATOM 2592 CZ PHE 331 87, .464 32 .502 13. .406 1. .00 56. .26 1SG2593
ATOM 2593 C PHE 331 81, .129 32, .185 14. .212 1. .00 56, .26 1SG2594
ATOM 2594 O PHE 331 80. .727 33, .329 14, .421 1. .00 56. .26 1SG2595
ATOM 2595 N THR 332 80. .414 31, .107 14, .569 1. .00 51. .52 1SG2596
ATOM 2596 CA THR 332 79. .159 31, .305 15. .225 1. ,00 51. .52 1SG2597
ATOM 2597 CB THR 332 78. .003 30, .936 14. .337 1. ,00 51. .52 1SG2598
ATOM 2598 OGl THR 332 76. .767 31 .132 15. .001 1. .00 51. .52 1SG2599
ATOM 2599 CG2 THR 332 78. .160 29, .491 13. .880 1. .00 51, .52 1SG2600
ATOM 2600 C THR 332 79. .163 30, .501 16. .490 1. .00 51. .52 1SG2601
ATOM 2601 O THR 332 79. .712 29, .402 16. .534 1. .00 51. .52 1SG2602
ATOM 2602 N LEU 333 78. .582 31, .061 17. .574 1. .00 49. .16 1SG2603
ATOM 2603 CA LEU 333 78. .557 30, .402 18. .852 1. .00 49. .16 1SG2604'
ATOM 2604 CB LEU 333 79. ,165 31. .233 19. ,990 1. .00 49. .16 1SG2605
ATOM 2605 CG LEU 333 80. ,694 31. .237 19. ,940 1. .00 49. .16 1SG2606
ATOM 2606 CD2 LEU 333 81. .292 32, .011 21. .124 1. .00 49. .16 1SG2607
ATOM 2607 CDl LEU 333 81. .195 31, .704 18. .570 1. .00 49. .16 1SG2608
ATOM 2608 C LEU 333 77. .150 30. .083 19. .235 1. .00 49. .16 1SG2609
ATOM 2609 O LEU 333 76. ,220 30. .826 18. ,923 1. .00 49. .16 1SG2610 ATOM 2610 N ASP 334 76..970 28..930 19..914 1..00 46.,27 1SG2611
ATOM 2611 CA ASP 334 75. .668 28. .516 20. .355 1. ,00 46. .27 1SG2612
ATOM 2612 CB ASP 334 75. ,246 27. .154 19. .775 1. ,00 46. .27 1SG2613
ATOM 2613 CG ASP 334 73. ,779 26. .922 20. .102 1. ,00 46. .27 1SG2614
ATOM 2614 ODl ASP 334 73. .172 27. .803 20. .768 1. ,00 46. .27 1SG2615
ATOM 2615 OD2 ASP 334 73. .244 25. .860 19. .684 1. .00 46. .27 1SG2616
ATOM 2616 C ASP 334 75. .713 28. .369 21. .851 1. .00 46. ,27 1SG2617
ATOM 2617 O ASP 334 76. .157 27. .347 22. .370 1. .00 46. .27 1SG2618
ATOM 2618 N ILE 335 75. ,234 29. .381 22. .599 1. ,00 44. .04 1SG2619
ATOM 2619 CA ILE 335 75. .308 29. .312 24. .035 1. .00 44. .04 1SG2620
ATOM 2620 CB ILE 335 75. ,750 30. .610 24. .647 1. .00 44. .04 1SG2621
ATOM 2621 CG2 ILE 335 75, .773 30. .420 26 .173 1. .00 44. .04 1SG2622
ATOM 2622 CGI ILE 335 77. .089 31 .086 24 .061 1. .00 44. .04 1SG2623
ATOM 2623 CDl ILE 335 78. .257 30. .146 24. .333 1. .00 44, .04 1SG2624
ATOM 2624 C ILE 335 73. .933 29. .088 24 .591 1. .00 44, .04 1SG2625
ATOM 2625 O ILE 335 73, .028 29. .876 24. .324 1. .00 44, .04 1SG2626
ATOM 2626 N PRO 336 73. .741 27. .983 25 .279 1. .00 39, .62 1SG2627
ATOM 2627 CA PRO 336 72. .511 27 .774 26, .008 1. .00 39. .62 1SG2628
ATOM 2628 CD PRO 336 74. .271 26. .734 24 .757 1. .00 39. .62 1SG2629
ATOM 2629 CB PRO 336 72, .190 26. .284 25 .898 1. .00 39. .62 1SG2630
ATOM 2630 CG PRO 336 73. .535 25. .633 25 .535 1, .00 39. .62 1SG2631
ATOM 2631 C PRO 336 72. .708 28 .218 27 .429 1. .00 39, .62 1SG2632
ATOM 2632 O PRO 336 73. .826 28. .110 27 .932 1. .00 39, .62 1SG2633
ATOM 2633 N ALA 337 71. .648 28, .676 28, .121 1. .00 34, .94 1SG2634
ATOM 2634 CA ALA 337 71. .843 29, .069 29, .486 1. .00 34, .94 1SG2635
ATOM 2635 CB ALA 337 72. .172 30, .562 29, .657 1. .00 34 , .94 1SG2636
ATOM 2636 C ALA 337 70. .573 28 .816 30 .227 1 .00 34 .94 1SG2637
ATOM 2637 O ALA 337 69, .487 28 .836 29 .649 1. .00 34 .94 1SG2638
ATOM 2638 N SER 338 70 .688 28 .558 31 .544 1 .00 33 .58 1SG2639
ATOM 2639 CA SER 338 69, .517 28 .367 3 .345 1. .00 33 .58 1SG2640
ATOM 2640 CB SER 338 69, .588 27 .162 33 .299 1 .00 33 .58 1SG2641
ATOM 2641 OG SER 338 69, .567 25 .947 32 .566 1. .00 33 .58 1SG2642
ATOM 2642 C SER 338 69, .420 29 .581 33 .201 1, .00 33 .58 1SG2643
ATOM 2643 O SER 338 70, .387 29 .972 33 .854 1, .00 33 .58 1SG2644
ATOM 2644 N ILE 339 68, .239 30 .222 33 .206 1. .00 36 .04 1SG2645
ATOM 2645 CA ILE 339 68. .068 31 .397 34 .001 1. .00 36 .04 1SG2646
ATOM 2646 CB ILE 339 67. .575 32 .574 33 .212 1. .00 36 .04 1SG2647
ATOM 2647 CG2 ILE 339 67. .351 33 .737 34 .191 1. .00 36, .04 1SG2648
ATOM 2648 CGI ILE 339 68, .551 32 .905 32 .070 1. .00 36, .04 1SG2649
ATOM 2649 CDl ILE 339 69. .958 33, .251 32 .548 1. .00 36, .04 1SG2650
ATOM 2650 C ILE 339 67. .002 31, .078 34 .995 1. .00 36. .04 1SG2651
ATOM 2651 O ILE 339 65, .886 30 .721 34 .622 1. .00 36 .04 1SG2652
ATOM 2652 N MET 340 67 .326 31 .200 36 .296 1, .00 40, .57 1SG2653
ATOM 2653 CA MET 340 66, .375 30 .901 37 .328 1, .00 40 .57 1SG2654
ATOM 2654 CB MET 340 66 .937 29 .962 38 .410 1. .00 40, .57 1SG2655
ATOM 2655 CG MET 340 67, .330 28, .572 37 .907 1, .00 40, .57 1SG2656
ATOM 2656 SD MET 340 65 .933 27 .482 37 .512 1, .00 40, .57 1SG2657
ATOM 2657 CE MET 340 66, .969 26, .075 37 .016 1, .00 40, .57 1SG2658
ATOM 2658 C MET 340 66. .074 32 .190 38 .033 1, .00 40. .57 1SG2659
ATOM 2659 O MET 340 66. .962 33, .003 38, .279 1, .00 40. .57 1SG2660
ATOM 2660 N MET 341 , 64. .791 32 .403 38 .379 1. .00 45. .68 1SG2661
ATOM 2661 CA MET 341 64, .361 33, .594 39, .055 1. .00 45, .68 1SG2662
ATOM 2662 CB MET 341 63. .121 34, .201 38 .361 1. .00 45, .68 1SG2663
ATOM 2663 CG MET 341 62, .506 35, .446 39, .007 1. ,00 45, .68 1SG2664
ATOM 2664 SD MET 341 61. .054 36. .111 38 .138 1. .00 45. .68 1SG2665
ATOM 2665 CE MET 341 62. .000 36. .854 36, .780 1. .00 45. .68 1SG2666
ATOM 2666 C MET 341 63. .997 33. .177 40 .443 1. .00 45. .68 1SG2667 ATOM 2667 O MET 341 63..305 32..179 40.,649 1.,00 45..68 1SG2668
ATOM 2668 N LEU 342 64. .489 33. ,936 41. ,437 1. ,00 49. .91 1SG2669
ATOM 2669 CA LEU 342 64. .299 33. .571 42. .804 1. ,00 49. .91 1SG2670
ATOM 2670 CB LEU 342 65. ,646 33. .318 43. .474 1. ,00 49. .91 1SG2671
ATOM 2671 CG LEU 342 65. .480 32. .620 44. .807 1. ,00 49. .91 1SG2672
ATOM 2672 CD2 LEU 342 66. .774 32. .651 45. .635 1. ,00 49. .91 1SG2673
ATOM 2673 CDl LEU 342 64. .924 31. .223 44. .513 1. .00 49. .91 1SG2674
ATOM 2674 C LEU 342 63. .726 34. .751 43. .518 1. ,00 49, .91 1SG2675
ATOM 2675 O LEU 342 64. .024 35. .891 43. .173 1. ,00 49. .91 1SG2676
ATOM 2676 N THR 343 62. .893 34. .505 44. .549 1. .00 51. .47 1SG2677
ATOM 2677 CA THR 343 62. .390 35. .592 45. .332 1. .00 51. .47 1SG2678
ATOM 2678 CB THR 343 60. .927 35. .484 45. .652 1. .00 51 .47 1SG2679
ATOM 2679 OGl THR 343 60. .678 34, .319 46. .424 1. .00 51 .47 1SG2680
ATOM 2680 CG2 THR 343 60. .136 35, .428 44, .334 1. .00 51 .47 1SG2681
ATOM 2681 C THR 343 63, .134 35, .499 46, .619 1. .00 51, .47 1SG2682
ATOM 2682 O THR 343 63, .348 34, .405 47, .138 1. .00 51 .47 1SG2683
ATOM 2683 N GLN 344 63, .585 36, .644 47, .158 1. .00 55 .90 1SG2684
ATOM 2684 CA GLN 344 64, .329 36, .551 48, .382 1. .00 55 .90 1SG2685
ATOM 2685 CB GLN 344 65, .565 37, .466 48, .418 1. .00 55 .90 1SG2686
ATOM 2686 CG GLN 344 66, .627 37, .097 47. .381 1, .00 55 .90 1SG2687
ATOM 2687 CD GLN 344 67, .784 38 .075 47. .526 1, .00 55 .90 1SG2688
ATOM 2688 OEl GLN 344 67, .753 38, .971 48, .368 1. .00 55 .90 1SG2689
ATOM 2689 NE2 GLN 344 68, .837 37, .898 46. .685 1. .00 55 .90 1SG2690
ATOM 2690 C GLN 344 63, .424 36, .982 49. .491 1. .00 55 .90 1SG2691
ATOM 2691 O GLN 344 63, .049 38 .149 49. .580 1. .00 55 .90 1SG2692
ATOM 2692 N PRO 345 63, .057 36, .066 50. .347 1. .00 62 .27 1SG2693
ATOM 2693 CA PRO 345 62, .216 36, .447 51. .447 1. .00 62 .27 1SG2694
ATOM 2694 CD PRO 345 62, .701 34, .743 49. .861 1. .00 62 .27 1SG2695
ATOM 2695 CB PRO 345 61, .539 35, .176 51. .944 1. .00 62 .27 1SG2696
ATOM 2696 CG PRO 345 61. .480 34, .299 50. .682 1. .00 62 .27 1SG2697
ATOM 2697 C PRO 345 62, .966 37. .200 52. .490 1. .00 62 .27 1SG2698
ATOM 2698 O PRO 345 64, .196 37. .190 52. .450 1, .00 62 .27 1SG2699
ATOM 2699 N LYS 346 62, .233 37, .870 53. .410 1. .00 66 .99 1SG2700
ATOM 2700 CA LYS 346 62, .841 38, .660 54. .444 1. .00 66 .99 1SG2701
ATOM 2701 CB LYS 346 61, .838 39, .522 55. .231 1. .00 66 .99 1SG2702
ATOM 2702 CG LYS 346 61, .208 40, .640 54. .398 1. .00 66 .99 1SG2703
ATOM 2703 CD LYS 346 59, .998 41, .298 55 .065 1. .00 66 .99 1SG2704
ATOM 2704 CE LYS 346 60, .370 42. .267 56, .189 1. .00 66 .99 1SG2705
ATOM 2705 NZ LYS 346 59, .146 42, .859 56, .773 1. .00 66 .99 1SG2706
ATOM 2706 C LYS 346 63 , .492 37, .733 55, .410 1. .00 66 .99 1SG2707
ATOM 2707 O LYS 346 62, .969 37, .410 56, .475 1. .00 66, .99 1SG2708
ATOM 2708 N ASN 347 64, .689 37, .301 55, .005 1. .00 70, .84 1SG2709
ATOM 2709 CA ASN 347 65, .611 36, .427 55, .648 1. .00 70, .84 1SG2710
ATOM 2710 CB ASN 347 65, .321 34 , .921 55, .501 1. .00 70, .84 1SG2711
ATOM 2711 CG ASN 347 63, .911 34, .568 55, .926 1. .00 70, .84 1SG2712
ATOM 2712 ODl ASN 347 63, .129 34, .136 55, .081 1. .00 70, .84 1SG2713
ATOM 2713 ND2 ASN 347 63, .582 34 , .733 57, .235 1. .00 70, .84 1SG2714
ATOM 2714 C ASN 347 66, .710 36, .588 54, .673 1. .00 70, .84 1SG2715
ATOM 2715 O ASN 347 67, .258 37, .668 54, .468 1. .00 70, .84 1SG2716
ATOM 2716 N SER 348 67. .039 35, .465 54. .032 1. .00 67, .31 1SG2717
ATOM 2717 CA SER 348 67. .939 35, .470 52, .932 1. .00 67, .31 1SG2718
ATOM 2718 CB SER 348 69. .403 35, .300 53, .360 1. .00 67, .31 1SG2719
ATOM 2719 OG SER 348 70. .244 35. .307 52. .216 1. .00 67, .31 1SG2720
ATOM 2720 C SER 348 67. .540 34. .242 52. .203 1. .00 67. .31 1SG2721
ATOM 2721 O SER 348 68. .258 33. .736 51. .343 1. .00 67. .31 1SG2722
ATOM 2722 N THR 349 66. .329 33. .753 52. .532 1. .00 61. .22 1SG2723
ATOM 2723 CA THR 349 65. .870 32. .529 51, .958 1. .00 61, .22 1SG2724 ATOM 2724 CB THR 349 64..662 31..956 52..641 1.,00 61..22 1SG2725
ATOM 2725 OGl THR 349 64. .340 30. .688 52. .088 1. .00 61. .22 1SG2726
ATOM 2726 CG2 THR 349 63. .488 32. .925 52. .486 1. .00 61. .22 1SG2727
ATOM 2727 C THR 349 65. .585 32. .754 50. .510 1. ,00 61. ,22 1SG2728
ATOM 2728 O THR 349 65. .381 33. .878 50. .058 1. .00 61, .22 1SG2729
ATOM 2729 N VAL 350 65. .617 31. .638 49, .762 1. .00 55, .85 1SG2730
ATOM 2730 CA VAL 350 65. .518 31. .495 48, .338 1. .00 55. .85 1SG2731
ATOM 2731 CB VAL 350 66, .635 30. .546 47, .971 1. .00 55. .85 1SG2732
ATOM 2732 CGI VAL 350 66, .460 29. .892 46, .601 1. .00 55. .85 1SG2733
ATOM 2733 CG2 VAL 350 67. .952 31. .322 48. .125 1. .00 55. .85 1SG2734
ATOM 2734 C VAL 350 64. .205 30. .847 47. .995 1. .00 55. .85 1SG2735
ATOM 2735 O VAL 350 63, .927 29, .734 48. .435 1. .00 55. .85 1SG2736
ATOM 2736 N GLU 351 63, .354 31. .520 47. .190 1. .00 51. .60 1SG2737
ATOM 2737 CA GLU 351 62, .129 30, .882 46. .778 1. .00 51, .60 1SG2738
ATOM 2738 CB GLU 351 60, .855 31. .611 47. .226 1. .00 51, .60 1SG2739
ATOM 2739 CG GLU 351 59, .586 30. .892 46. .765 1. .00 51, .60 1SG2740
ATOM 2740 CD GLU 351 59, .482 29. .585 47. .537 1. , 00 51, .60 1SG2741
ATOM 2741 OEl GLU 351 60 .372 29. .330 48, .392 1. .00 51 .60 1SG2742
ATOM 2742 OE2 GLU 351 58 .512 28, .822 47, .284 1. .00 51, .60 1SG2743
ATOM 2743 C GLU 351 62 .117 30, .870 45, .280 1. .00 51, .60 1SG2744
ATOM 2744 O GLU 351 62 .098 31. .924 44, .648 1. .00 51, .60 1SG2745
ATOM 2745 N THR 352 62, .128 29. .665 44, .668 1. .00 49, .54 1SG2746
ATOM 2746 CA THR 352 62, .236 29. .555 43, .237 1. .00 49, .54 1SG2747
ATOM 2747 CB THR 352 62, .644 28. .179 42, .782 1. .00 49, .54 1SG2748
ATOM 2748 OGl THR 352 62 .787 28. .153 41 .370 1. .00 49 .54 1SG2749
ATOM 2749 CG2 THR 352 61 .603 27, .145 43 .244 1. .00 49 .54 1SG2750
ATOM 2750 C THR 352 60 .952 29, .916 42 .555 1. .00 49 .54 1SG2751
ATOM 2751 O THR 352 59, .931 29. .251 42, .727 1. .00 49. .54 1SG2752
ATOM 2752 N ILE 353 60, .953 31. .037 41, .799 1. .00 47, .44 1SG2753
ATOM 2753 CA ILE 353 59, .776 31. .383 41, .059 1. .00 47, .44 1SG2754
ATOM 2754 CB ILE 353 59 .641 32. .846 40 .754 1. .00 47 .44 1SG2755
ATOM 2755 CG2 ILE 353 60 .723 33. .231 39 .750 1, .00 47 .44 1SG2756
ATOM 2756 CGI ILE 353 58 .216 33. .156 40 .268 1. .00 47 .44 1SG2757
ATOM 2757 CDl ILE 353 57, .149 32, .960 41, .344 1, .00 47, .44 1SG2758
ATOM 2758 C ILE 353 59, .635 30. .590 39, .782 1. .00 47, .44 1SG2759
ATOM 2759 O ILE 353 58, .584 30. .001 39, .536 1. .00 47, .44 1SG2760
ATOM 2760 N VAL 354 60, .690 30. .536 38, .930 1. .00 42 , .89 1SG2761
ATOM 2761 CA VAL 354 60 .559 29, .851 37 .665 1. .00 42 .89 1SG2762
ATOM 2762 CB VAL 354 59 .749 30, .628 36 .666 1. .00 42 .89 1SG2763
ATOM 2763 CGI VAL 354 60, .520 31, .910 36, .309 1. .00 42, .89 1SG2764
ATOM 2764 CG2 VAL 354 59, .439 29, .727 35, .459 1. .00 42, .89 1SG2765
ATOM 2765 C VAL 354 61, .916 29. .626 37, .055 1. .00 42, .89 1SG2766
ATOM 2766 O VAL 354 62. .901 30. .263 37, .425 1. .00 42 , .89 1SG2767
ATOM 2767 N SER 355 61 .994 28. .694 36 .080 1. .00 37, .08 1SG2768
ATOM 2768 CA SER 355 63. .236 28. .403 35, .416 1. .00 37, .08 1SG2769
ATOM 2769 CB SER 355 63. .653 26. .928 35, .533 1. .00 37, .08 1SG2770
ATOM 2770 OG SER 355 62, .691 26. .097 34, .902 1. .00 37, .08 1SG2771
ATOM 2771 C SER 355 63, .055 28. .694 33, .958 1. .00 37, .08 1SG2772
ATOM 2772 O SER 355 62, .041 28. .333 33, .363 1. .00 37. .08 1SG2773
ATOM 2773 N MET 356 64. .050 29. .359 33. .338 1. .00 33. .75 1SG2774
ATOM 2774 CA MET 356 63. .935 29. .703 31. .950 1. .00 33, .75 1SG2775
ATOM 2775 CB MET 356 63. .973 31. .220 31, .700 1. .00 33, .75 1SG2776
ATOM 2776 CG MET 356 62, .770 31. .958 32, .292 1. .00 33, .75 1SG2777
ATOM 2777 SD MET 356 62, .860 33. .770 32. .175 1. ,00 33. .75 1SG2778
ATOM 2778 CE MET 356 64. .012 33. ,959 33. .566 1. ,00 33. .75 1SG2779
ATOM 2779 C MET 356 65. .084 29. ,102 31. .212 1. ,00 33. .75 1SG2780
ATOM 2780 O MET 356 66, .191 28. .986 31. .738 1. .00 33. .75 1SG2781 ATOM 2781 N ASP 357 64..826 28..683 29.,958 1..00 30..58 1SG2782
ATOM 2782 CA ASP 357 65. .854 28. .115 29. ,139 1. .00 30. .58 1SG2783
ATOM 2783 CB ASP 357 65. .461 26. .766 28. ,514 1. 00 30. .58 1SG2784
ATOM 2784 CG ASP 357 65. .382 25, .740 29. .636 1. .00 30. .58 1SG2785
ATOM 2785 ODl ASP 357 65. .829 26. .068 30. ,767 1. ,00 30. .58 1SG2786
ATOM 2786 OD2 ASP 357 64. .869 24. .618 29. ,379 1. ,00 30. .58 1SG2787
ATOM 2787 C ASP 357 66. .093 29. .076 28. .021 1. .00 30. .58 1SG2788
ATOM 2788 O ASP 357 65. .215 29. .331 27. .199 1. .00 30. .58 1SG2789
ATOM 2789 N PHE 358 67. .309 29. .644 27. .980 1. .00 31. .26 1SG2790
ATOM 2790 CA PHE 358 67, .686 30. .589 26. .973 1. .00 31, .26 1SG2791
ATOM 2791 CB PHE 358 68. .289 31. .877 27. .568 1. .00 31, .26 1SG2792
ATOM 2792 CG PHE 358 69. .244 32, .451 26. .576 1. .00 31. .26 1SG2793
ATOM 2793 CDl PHE 358 68, .829 33, .250 25. ,536 1. ,00 31. .26 1SG2794
ATOM 2794 CD2 PHE 358 70, .587 32, .163 26. .695 1. .00 31, .26 1SG2795
ATOM 2795 CE1 PHE 358 69. .745 33, .755 24. .641 1. .00 31. .26 1SG2796
ATOM 2796 CE2 PHE 358 71. .505 32, .664 25. .805 1. .00 31. .26 1SG2797
ATOM 2797 CZ PHE 358 71, .082 33, .465 24 , .773 1. .00 31 .26 1SG2798
ATOM 2798 C PHE 358 68, .712 29, .979 26. .078 1. .00 31. .26 1SG2799
ATOM 2799 O PHE 358 69, .573 29, .219 26. .517 1. .00 31. .26 1SG2800
ATOM 2800 N VAL 359 68, .614 30 .305 24. .775 1. .00 33 .53 1SG2801
ATOM 2801 CA VAL 359 69, .549 29 .859 23. .785 1. .00 33 .53 1SG2802
ATOM 2802 CB VAL 359 69, .102 28, .621 23. .065 1. .00 33 .53 1SG2803
ATOM 2803 CGI VAL 359 69. .008 27 .469 24. .081 1. .00 33 .53 1SG2804
ATOM 2804 CG2 VAL 359 67. .775 28 .926 22. .349 1. .00 33 .53 1SG2805
ATOM 2805 C VAL 359 69, .601 30, .964 22. .780 1. .00 33. .53 1SG2806
ATOM 2806 O VAL 359 68 .668 31 .759 22. .678 1. .00 33 .53 1SG2807
ATOM 2807 N ALA 360 70 .704 31 .063 22, .017 1, .00 34 .73 1SG2808
ATOM 2808 CA ALA 360 70, .794 32 .125 21. .059 1. .00 34 .73 1SG2809
ATOM 2809 CB ALA 360 71, .165 33, .485 21. .682 1. .00 34, .73 1SG2810
ATOM 2810 C ALA 360 71 .873 31 .768 20, .095 1. .00 34 .73 1SG2811
ATOM 2811 O ALA 360 72, .454 30 .688 20. .174 1. .00 34 .73 1SG2812
ATOM 2812 N SER 361 72, .122 32, .668 19. .123 1. .00 37 .86 1SG2813
ATOM 2813 CA SER 361 73 .173 32 .505 18, .167 1, .00 37 .86 1SG2814
ATOM 2814 CB SER 361 72 .687 32 .441 16, .709 1. .00 37 .86 1SG2815
ATOM 2815 OG SER 361 73, .796 32 .278 15. .840 1. .00 37 .86 1SG2816
ATOM 2816 C SER 361 74 .019 33 .729 18. .332 1, .00 37 .86 1SG2817
ATOM 2817 O SER 361 73 .528 34 .774 18, .756 1. .00 37 .86 1SG2818
ATOM 2818 N THR 362 75, .325 33 .630 18. .034 1. .00 38 .33 1SG2819
ATOM 2819 CA THR 362 76 .186 34 .746 18. .289 1. .00 38 .33 1SG2820
ATOM 2820 CB THR 362 76 .859 34 .574 19. .622 1. .00 38 .33 1SG2821
ATOM 2821 OGl THR 362 75 .886 34 .527 20, .653 1. .00 38 .33 1SG2822
ATOM 2822 CG2 THR 362 77, .883 35 .688 19. .875 1. .00 38, .33 1SG2823
ATOM 2823 C THR 362 77 .270 34 .743 17. .268 1. .00 38 .33 1SG2824
ATOM 2824 O THR 362 77, .567 33 .716 16. .662 1. .00 38 .33 1SG2825
ATOM 2825 N SER 363 77, .908 35, .908 17. .060 1. .00 38, .42 1SG2826
ATOM 2826 CA SER 363 79 .002 35 .930 16. .142 1. .00 38 .42 1SG2827
ATOM 2827 CB SER 363 78 .908 37 .046 15. .090 1. .00 38 .42 1SG2828
ATOM 2828 OG SER 363 80. .031 36 .996 14. .224 1. .00 38, .42 1SG2829
ATOM 2829 C SER 363 80 .209 36 .185 16. .972 1, .00 38 .42 1SG2830
ATOM 2830 O SER 363 80 .190 37 .044 17, .854 1, .00 38 .42 1SG2831
ATOM 2831 N VAL 364 81, .294 35, .421 16 , .747 1. .00 38, .68 1SG2832
ATOM 2832 CA VAL 364 82 .454 35 .735 17, .517 1. .00 38 .68 1SG2833
ATOM 2833 CB VAL 364 83 .006 34 .625 18, .359 1. .00 38 .68 1SG2834
ATOM 2834 CGI VAL 364 82, .009 34, .368 19, .501 1. .00 38, .68 1SG2835
ATOM 2835 CG2 VAL 364 83 .314 33 .419 17. .455 1. .00 38 .68 1SG2836
ATOM 2836 C VAL 364 83 .523 36. .212 16, .601 1. .00 38 .68 1SG2837
ATOM 2837 O VAL 364 83, .971 35, .490 15. .710 1. .00 38, .68 1SG2838 ATOM 2838 N GLY 365 83.942 37.475 16.805 1.00 37.93 1SG2839
ATOM 2839 CA GLY 365 84. .994 38 .026 16 .012 1, .00 37, .93 1SG2840
ATOM 2840 C GLY 365 86. .282 37 .643 16 .663 1, .00 37, .93 1SG2841
ATOM 2841 O GLY 365 86. .352 37. .505 17 .884 1, .00 37, .93 1SG2842
ATOM 2842 N LEU 366 87, .350 37 .478 15 .861 1, .00 40, .25 1SG2843
ATOM 2843 CA LEU 366 88, .615 37 .141 16 .444 1, .00 40, .25 1SG2844
ATOM 2844 CB LEU 366 89, .075 35. .700 16 .156 1, .00 40, .25 1SG2845
ATOM 2845 CG LEU 366 88, .196 34 .632 16 .835 1, .00 40, .25 1SG2846
ATOM 2846 CD2 LEU 366 88, .846 33 .240 16 .765 1 .00 40, .25 1SG2847
ATOM 2847 CDl LEU 366 86, .761 34. .651 16 .285 1, .00 40, .25 1SG2848
ATOM 2848 C LEU 366 89, .653 38 .075 15 .908 1, .00 40, .25 1SG2849
ATOM 2849 O LEU 366 89, .716 38 .336 14 .707 1 .00 40, .25 1SG2850
ATOM 2850 N VAL 367 90, .497 38. .602 16 .818 1, .00 41, .59 1SG2851
ATOM 2851 CA VAL 367 91, .542 39 .523 16 .476 1 .00 41, .59 1SG2852
ATOM 2852 CB VAL 367 91. .221 40 .942 16 .842 1 .00 41 .59 1SG2853
ATOM 2853 CGI VAL 367 89. .993 41. .390 16 .031 1, .00 41, .59 1SG2854
ATOM 2854 CG2 VAL 367 91, .024 41 .020 18 .366 1, .00 41, .59 1SG2855
ATOM 2855 C VAL 367 92. .739 39. .126 17 .277 1, .00 41, .59 1SG2856
ATOM 2856 O VAL 367 92. .655 38. .259 18 .146 1, .00 41, .59 1SG2857
ATOM 2857 N ILE 368 93. .905 3 .732 16 .982 1, .00 44, .05 1SG2858
ATOM 2858 CA ILE 368 95, .076 39. .334 17. .705 1, .00 44, .05 1SG2859
ATOM 2859 CB ILE 368 96, .026 38. .573 16 .815 1, .00 44, .05 1SG2860
ATOM 2860 CG2 ILE 368 96, .678 39 .566 15 .838 1, .00 44, .05 1SG2861
ATOM 2861 CGI ILE 368 97, .021 37, .741 17 .630 1, .00 44, .05 1SG2862
ATOM 2862 CDl ILE 368 97, .914 38, .579 18 .531 1, .00 44, .05 1SG2863
ATOM 2863 C ILE 368 95, .750 40 .563 18 .245 1, .00 44, .05 1SG2864
ATOM 2864 O ILE 368 95, .908 41, .564 17 .548 1, .00 44, .05 1SG2865
ATOM 2865 N LEU 369 96, .133 40, .524 19 .536 1, .00 47. .75 1SG2866
ATOM 2866 CA LEU 369 96. .849 41, .606 20 .142 1, .00 47. .75 1SG2867
ATOM 2867 CB LEU 369 96, .052 42, .309 21 .265 1, .00 47. .75 1SG2868
ATOM 2868 CG LEU 369 96, .673 43, .610 21 .836 1, .00 47. .75 1SG2869
ATOM 2869 CD2 LEU 369 98. .121 43 , .429 22, .318 1. .00 47. .75 1SG2870
ATOM 2870 CDl LEU 369 95. .776 44, .202 22 .936 1. .00 47. .75 1SG2871
ATOM 2871 C LEU 369 98. .048 40, .952 20 .743 1, .00 47. .75 1SG2872
ATOM 2872 O LEU 369 97. .931 39, .909 21, .386 1. .00 47. .75 1SG2873
ATOM 2873 N GLY 370 99. .242 41, .534 20, .528 1. .00 49, .61 1SG2874
ATOM 2874 CA GLY 370 100, .410 40 .916 21, .075 1, .00 49, .61 1SG2875
ATOM 2875 C GLY 370 100. .493 39. .541 20, .482 1. .00 49. .61 1SG2876
ATOM 2876 O GLY 370 100. .424 39, .365 19, .269 1. .00 49. .61 1SG2877
ATOM 2877 N GLN 371 100. .753 38, .555 21, .357 1. .00 53. .67 1SG2878
ATOM 2878 CA GLN 371 100. .827 37. .139 21. .107 1. .00 53. .67 1SG2879
ATOM 2879 CB GLN 371 101. .734 36. .412 22. .116 1. .00 53. .67 1SG2880
ATOM 2880 CG GLN 371 103. .199 36. .852 22. .053 1. .00 53. ,67 1SG2881
ATOM 2881 CD GLN 371 103. .974 36. .060 23. .097 1. .00 53. ,67 1SG2882
ATOM 2882 OEl GLN 371 105. .184 36. .218 23, .248 1. .00 53. .67 1SG2883
ATOM 2883 NE2 GLN 371 103. .257 35. .171 23. .837 1. .00 53. .67 1SG2884
ATOM 2884 C GLN 371 99. .483 36. .454 21. .155 1. ,00 53. ,67 1SG2885
ATOM 2885 O GLN 371 99. .343 35. .320 20. .694 1. .00 53. ,67 1SG2886
ATOM 2886 N ARG 372 98. .496 37. .079 21. .831 1. .00 55. ,25 1SG2887
ATOM 2887 CA ARG 372 97. ,252 36. ,430 22. .174 1. ,00 55. .25 1SG2888
ATOM 2888 CB ARG 372 96. ,636 37. .000 23. .461 1. ,00 55. .25 1SG2889
ATOM 2889 CG ARG 372 96. 350 38. ,499 23. .379 1. ,00 55. 25 1SG2890
ATOM 2890 CD ARG 372 95. ,846 39. ,079 24. .700 1. ,00 55. .25 1SG2891
ATOM 2891 NE ARG 372 95. .616 40. .537 24. .503 1. .00 55. .25 1SG2892
ATOM 2892 CZ ARG 372 95. 562 41. .367 25. .585 1. 00 55. 25 1SG2893
ATOM 2893 NHl ARG 372 95. 711 40. ,859 26. .844 1. .00 55. 25 1SG2894
ATOM 2894 NH2 ARG 372 95. 366 42. .706 25. ,409 1. 00 55. 25 1SG2895 ATOM 2895 C ARG 372 96..183 36..441 21..123 1..00 55..25 1SG2896
ATOM 2896 O ARG 372 96. .176 37. .245 20. .193 1. .00 55. .25 1SG2897
ATOM 2897 N LEU 373 95. ,238 35. .481 21. .277 1. .00 52. .75 1SG2898
ATOM 2898 CA LEU 373 94. ,085 35. .328 20. .435 1. .00 52. .75 1SG2899
ATOM 2899 CB LEU 373 93. .791 33. .852 20. .092 1. .00 52. .75 1SG2900
ATOM 2900 CG LEU 373 92. ,568 33. .630 19. .180 1. .00 52. .75 1SG2901
ATOM 2901 CD2 LEU 373 92. ,192 32. .138 19. .097 1. .00 52. .75 1SG2902
ATOM 2902 CDl LEU 373 92. .785 34, .265 17, .799 1. .00 52, .75 1SG2903
ATOM 2903 C LEU 373 92. .940 35, .854 21. .244 1. .00 52, .75 1SG2904
ATOM 2904 O LEU 373 92, .595 35, .294 22. .281 1. .00 52, .75 1SG2905
ATOM 2905 N VAL 374 92. .324 36, .962 20. .787 1. .00 50, .63 1SG2906
ATOM 2906 CA VAL 374 91, .272 37, .558 21, .559 1. .00 50, .63 1SG2907
ATOM 2907 CB VAL 374 91. .564 38, .975 21. .952 1. .00 50, .63 1SG2908
ATOM 2908 CGI VAL 374 90, .383 39, .499 22. .761 1. .00 50, .63 1SG2909
ATOM 2909 CG2 VAL 374 92. .884 39. .027 22. .729 1. .00 50, .63 1SG2910
ATOM 2910 C VAL 374 90. .048 37. .598 20. .707 1. .00 50 .63 1SG2911
ATOM 2911 O VAL 374 90, .134 37, .613 19. .482 1, .00 50, .63 1SG2912
ATOM 2912 N CYS 375 88, .855 37, .590 21. .339 1, .00 46 .64 1SG2913
ATOM 2913 CA CYS 375 87, .657 37 .627 20 .558 1, .00 46 .64 1SG2914
ATOM 2914 CB CYS 375 87, .078 36, .232 20. .265 1, .00 46 .64 1SG2915
ATOM 2915 SG CYS 375 86, .586 35 .354 21 .778 1. .00 46 .64 1SG2916
ATOM 2916 C CYS 375 86, .604 38, .385 21. .300 1. .00 46 .64 1SG2917
ATOM 2917 O CYS 375 86, .791 38 .776 22 .451 1, .00 46 .64 1SG2918
ATOM 2918 N SER 376 85. .465 38, .631 20. .620 1, .00 45, .16 1SG2919
ATOM 2919 CA SER 376 84. .355 39 .303 21 .228 1, .00 45 .16 1SG2920
ATOM 2920 CB SER 376 84. .177 40, .762 20. .774 1, .00 45 .16 1SG2921
ATOM 2921 OG SER 376 85. .293 41 .537 21 .186 1, .00 45 .16 1SG2922
ATOM 2922 C SER 376 83 .129 38 .550 20 .823 1 .00 45 .16 1SG2923
ATOM 2923 O SER 376 83. .075 37 .953 19 .749 1, .00 45 .16 1SG2924
ATOM 2924 N LEU 377 82 .109 38 .557 21 .699 1 .00 46 .86 1SG2925
ATOM 2925 CA LEU 377 80, .892 37 .834 21 .470 1, .00 46 .86 1SG2926
ATOM 2926 CB LEU 377 80, .422 37 .100 22 .735 1 .00 46 .86 1SG2927
ATOM 2927 CG LEU 377 79, .281 36 .106 22 .485 1, .00 46, .86 1SG2928
ATOM 2928 CD2 LEU 377 78, .404 35 .902 23 .725 1, .00 46 .86 1SG2929
ATOM 2929 CDl LEU 377 79, .833 34 .805 21 .890 1, .00 46, .86 1SG2930
ATOM 2930 C LEU 377 79, .820 38 .851 21 .210 1, .00 46 .86 1SG2931
ATOM 2931 O LEU 377 79 .751 39 .862 21 .907 1 .00 46 .86 1SG2932
ATOM 2932 N SER 378 78, .958 38 .613 20 .198 1, .00 47 .86 1SG2933
ATOM 2933 CA SER 378 77 .869 39 .518 19 .938 1, .00 47 .86 1SG2934
ATOM 2934 CB SER 378 78, .074 40 .376 18 .677 1, .00 47 .86 1SG2935
ATOM 2935 OG SER 378 76, .963 41 .239 18 .482 1, .00 47 .86 1SG2936
ATOM 2936 C SER 378 76, .647 38 .682 19, .716 1. .00 47, .86 1SG2937
ATOM 2937 O SER 378 76, .606 37 .843 18 .820 1, .00 47, .86 1SG2938
ATOM 2938 N LEU 379 75, .598 38 .904 20, .529 1, .00 49, .28 1SG2939
ATOM 2939 CA LEU 379 74, .416 38 .086 20 .484 1, .00 49, .28 1SG2940
ATOM 2940 CB LEU 379 73. .694 38 .021 21 .842 1. .00 49, .28 ■1SG2941
ATOM 2941 CG LEU 379 74, .537 37 .464 23 .011 1, .00 49, .28 1SG2942
ATOM 2942 CD2 LEU 379 75, .764 38 .339 23 .295 1, .00 49, .28 1SG2943
ATOM 2943 CDl LEU 379 74 , .899 35 .988 22 .806 1. .00 49, .28 1SG2944
ATOM 2944 C LEU 379 73. .416 38 .629 19 .504 1, .00 49 .28 1SG2945
ATOM 2945 O LEU 379 73. .486 39 .781 19 .081 1. .00 49, .28 1SG2946
ATOM 2946 N ASN 380 72. .440 37 .775 19 .129 1. .00 48, .43 1SG2947
ATOM 2947 CA ASN 380 71. .349 38, .160 18, .279 1. .00 48. .43 1SG2948
ATOM 2948 CB ASN 380 71. .320 37 .471 16 .898 1, .00 48. .43 1SG2949
ATOM 2949 CG ASN 380 71, .356 35, .959 17, .032 1, .00 48 , .43 1SG2950
ATOM 2950 ODl ASN 380 72. .329 35. .346 16 .596 1. .00 48, .43 1SG2951
ATOM 2951 ND2 ASN 380 70. .290 35 .347 17 .616 1, .00 48, .43 1SG2952 ATOM 2952 C ASN 380 70..093 37..906 19..062 1..00 48..43 1SG2953
ATOM 2953 O ASN 380 70. .116 38. .004 20. .288 1. .00 48. ,43 1SG2954
ATOM 2954 N ARG 381 68. .951 37. .606 18, .406 1. .00 47. .01 1SG2955
ATOM 2955 CA ARG 381 67. .738 37. .453 19, .167 1. ,00 47. .01 1SG2956
ATOM 2956 CB ARG 381 66. .476 37. .078 18. .365 1. .00 47. .01 1SG2957
ATOM 2957 CG ARG 381 66, .051 38, .085 17. .297 1. .00 47, .01 1SG2958
ATOM 2958 CD ARG 381 66, .644 37, .808 15. .917 1. .00 47. .01 1SG2959
ATOM 2959 NE ARG 381 65, .898 36. .635 15. .374 1. .00 47. .01 1SG2960
ATOM 2960 CZ ARG 381 65. .752 36. .463 14 , .028 1. ,00 47. .01 1SG2961
ATOM 2961 NHl ARG 381 66. .302 37, .362 13 .164 1. .00 47. .01 1SG2962
ATOM 2962 NH2 ARG 381 65, .058 35, .389 13. .547 1. .00 47. .01 1SG2963
ATOM 2963 C ARG 381 67, .902 36. .369 20, .187 1. .00 47. .01 1SG2964
ATOM 2964 O ARG 381 68. .596 35. .376 19, .976 1. ,00 47. .01 1SG2965
ATOM 2965 N PHE 382 67. .243 36, .568 21, .345 1. .00 44. .24 1SG2966
ATOM 2966 CA PHE 382 67. .271 35, .658 22. .448 1. .00 44. .24 1SG2967
ATOM 2967 CB PHE 382 67. .434 36. .407 23, .782 1. .00 44. .24 1SG2968
ATOM 2968 CG PHE 382 66. .586 37. .636 23, .718 1. .00 44. .24 1SG2969
ATOM 2969 CDl PHE 382 65, .263 37, .643 24, .100 1. .00 44, .24 1SG2970
ATOM 2970 CD2 PHE 382 67, .141 38, .810 23, .255 1. .00 44, .24 1SG2971
ATOM 2971 CE1 PHE 382 64, .519 38. .801 24, .026 1. .00 44, .24 1SG2972
ATOM 2972 CE2 PHE 382 66, .403 39 .968 23 .178 1. .00 44 .24 1SG2973
ATOM 2973 CZ PHE 382 65, .085 39, .966 23 .565 1, .00 44, .24 1SG2974
ATOM 2974 C PHE 382 66, .021 34, .843 22, .424 1. .00 44, .24 1SG2975
ATOM , 2975 O PHE 382 64, .936 35, .335 22 , .120 1. .00 44, .24 1SG2976
ATOM 2976 N ARG 383 66 .174 33, .542 22 .728 1. .00 41 .41 1SG2977
ATOM 2977 CA ARG 383 65, .113 32, .587 22 .627 1, .00 41, .41 1SG2978
ATOM 2978 CB ARG 383 65, .606 31. .438 21 .738 1. .00 41, .41 1SG2979
ATOM 2979 CG ARG 383 64, .575 30, .495 21, .145 1. .00 41, .41 1SG2980
ATOM 2980 CD ARG 383 65, .148 29, .801 19 .905 1. .00 41 .41 1SG2981
ATOM 2981 NE ARG 383 64, .216 28, .710 19 .524 1. .00 41 .41 1SG2982
ATOM 2982 CZ ARG 383 64, .521 27, .420 19, .847 1, .00 41, .41 1SG2983
ATOM 2983 NHl ARG 383 65, .736 27, .126 20. .389 1. .00 41, .41 1SG2984
ATOM 2984 NH2 ARG 383 63, .608 26, .430 19. .637 1. .00 41 .41 1SG2985
ATOM 2985 C ARG 383 64, .829 32, .084 24 , .007 1. .00 41, .41 1SG2986
ATOM 2986 O ARG 383 65, .723 31, .594 24. .696 1. .00 41. .41 1SG2987
ATOM 2987 N LEU 384 63. .559 32. .200 24. .448 1. .00 39. .77 1SG2988
ATOM 2988 CA LEU 384 63. .191 31 .791 25, .771 1, .00 39. .77 1SG2989
ATOM 2989 CB LEU 384 62, .331 32, .827 26. .514 1, .00 39, .77 1SG2990
ATOM 2990 CG LEU 384 63. .050 34. .156 26. .795 1. .00 39, .77 1SG2991
ATOM 2991 CD2 LEU 384 62. .220 35. .040 27, .738 1. .00 39, .77 1SG2992
ATOM 2992 CDl LEU 384 63. .432 34, .875 25, .493 1. .00 39, .77 1SG2993
ATOM 2993 C LEU 384 62, .355 30, .557 25, .681 1. .00 39, .77 1SG2994
ATOM 2994 O LEU 384 61, .678 30, .311 24. .683 1. ,00 39. .77 1SG2995
ATOM 2995 N ALA 385 62, .416 29, .738 26, .748 1. .00 37, .53 1SG2996
ATOM 2996 CA ALA 385 61, .629 28, .547 26, .864 1. .00 37. .53 1SG2997
ATOM 2997 CB ALA 385 62, .381 27, .270 26. .449 1. .00 37. .53 1SG2998
ATOM 2998 C ALA 385 61. .317 28. .425 28. .321 1. .00 37. .53 1SG2999
ATOM 2999 O ALA 385 62. .131 28. .799 29. .165 1. .00 37. .53 1SG3000
ATOM 3000 N LEU 386 60. .122 27. .903 28, .661 1. .00 37. .72 1SG3001
ATOM 3001 CA LEU 386 59. .761 27. .802 30. .046 1. .00 37. .72 1SG3002
ATOM 3002 CB LEU 386 58. .311 28. .254 30. .297 1. .00 37. ,72 1SG3003
ATOM 3003 CG LEU 386 57. .886 28. .244 31. .774 1. .00 37. .72 1SG3004
ATOM 3004 CD2 LEU 386 56. .366 28, .426 31. .913 1. ,00 37. .72 1SG3005
ATOM 3005 CDl LEU 386 58. .683 29. .278 32. .587 1. ,00 37. .72 1SG3006
ATOM 3006 C LEU 386 59. .868 26. .361 30. .450 1. ,00 37. .72 1SG3007
ATOM 3007 O LEU 386 59. .109 25. .518 29. .974 1. ,00 37. .72 1SG3008
ATOM 3008 N PRO 387 60. .871 26. .041 31. .230 1. .00 38. .47 1SG3009 ATOM 3009 CA PRO 387 61..013 24..706 31..756 1..00 38..47 1SG3010
ATOM 3010 CD PRO 387 62. .159 26. .691 31. .067 1. .00 38. .47 1SG3011
ATOM 3011 CB PRO 387 62. .491 24. .538 32. .118 1. .00 38. .47 1SG3012
ATOM 3012 CG PRO 387 63. .073 25. .962 32. .063 1. .00 38. .47 1SG3013
ATOM 3013 C PRO 387 60. .077 24. .307 32. .862 1. .00 38. .47 1SG3014
ATOM 3014 O PRO 387 59. .591 23. .177 32. .842 1. .00 38. .47 1SG3015
ATOM 3015 N GLU 388 59. .818 25. .200 33, .841 1. .00 43. .06 1SG3016
ATOM 3016 CA GLU 388 58. .960 24, .856 34, .941 1. .00 43. .06 1SG3017
ATOM 3017 CB GLU 388 59. .595 23. .859 35. .927 1. .00 43. .06 1SG3018
ATOM 3018 CG GLU 388 60. .875 24. .383 36, .582 1. .00 43. .06 1SG3019
ATOM 3019 CD GLU 388 61. .398 23. .309 37 .526 1, .00 43, .06 1SG3020
ATOM 3020 OEl GLU 388 60. .747 22. .234 37, .618 1. .00 43. .06 1SG3021
ATOM 3021 OE2 GLU 388 62. .456 23, .550 38, .166 1. .00 43. .06 1SG3022
ATOM 3022 C GLU 388 58. .690 26. .115 35. .702 1. .00 43. .06 1SG3023
ATOM 3023 O GLU 388 59, .541 26. .999 35. .768 1. .00 43. .06 1SG3024
ATOM 3024 N SER 389 57, .486 26. .238 36 .297 1. .00 48, .89 1SG3025
ATOM 3025 CA SER 389 57. .206 27. .447 37, .010 1. .00 48. .89 1SG3026
ATOM 3026 CB SER 389 56. .334 28, .433 36. .214 1. .00 48. .89 1SG3027
ATOM 3027 OG SER 389 56 .094 29 .605 36 .978 1 .00 48 .89 1SG3028
ATOM 3028 C SER 389 56, .462 27, .111 38. .258 1. .00 48. .89 1SG3029
ATOM 3029 O SER 389 55 .519 26, .322 38 .247 1 .00 48 .89 1SG3030
ATOM 3030 N ASN 390 56. .909 27. .697 39. .381 1. .00 54. .28 1SG3031
ATOM 3031 CA ASN 390 56. .261 27. .513 40. .640 1. .00 54, .28 1SG3032
ATOM 3032 CB ASN 390 57 .137 27 .985 41 .808 1 .00 54 .28 1SG3033
ATOM 3033 CG ASN 390 56. .691 27. .182 43, .009 1. .00 54, .28 1SG3034
ATOM 3034 ODl ASN 390 55 .886 26. .266 42 .848 1, .00 54 .28 1SG3035
ATOM 3035 ND2 ASN 390 57 .222 27 .508 44 .218 1 .00 54 .28 1SG3036
ATOM 3036 C ASN 390 55. .006 28. .341 40, .628 1, .00 54, .28 1SG3037
ATOM 3037 O ASN 390 53 .992 27. .985 41 .225 1 .00 54 .28 1SG3038
ATOM 3038 N ARG 391 55. .093 29. .500 39, .945 1, .00 59, .23 1SG3039
ATOM 3039 CA ARG 391 54, .105 30. .536 39 .808 1 .00 59 .23 1SG3040
ATOM 3040 CB ARG 391 54 .699 31. .779 39 .121 1 .00 59 .23 1SG3041
ATOM 3041 CG ARG 391 53, .681 32, .847 38, .727 1, .00 59, .23 1SG3042
ATOM 3042 CD ARG 391 53 .374 32, .850 37 .227 1 .00 59 .23 1SG3043
ATOM 3043 NE ARG 391 52 .147 32 .034 37 .011 1 .00 59 .23 1SG3044
ATOM 3044 CZ ARG 391 51, .276 32, .372 36 .015 1 .00 59, .23 1SG3045
ATOM 3045 NHl ARG 391 51 .540 33, .448 35 .218 1 .00 59 .23 1SG3046
ATOM 3046 NH2 ARG 391 50, .141 31, .640 35, .818 1, .00 59, .23 1SG3047
ATOM 3047 C ARG 391 52, .900 30, .114 39 .027 1 .00 59, .23 1SG3048
ATOM 3048 O ARG 391 51 .828 30, .656 39 .268 1 .00 59 .23 1SG3049
ATOM 3049 N SER 392 53. .061 29, .225 38, .027 1. .00 55, .95 1SG3050
ATOM 3050 CA SER 392 52. .027 28, .689 37, .171 1, .00 55, .95 1SG3051
ATOM 3051 CB SER 392 50 .592 29, .237 37 .321 1 .00 55 .95 1SG3052
ATOM 3052 OG SER 392 50. .069 28, .890 38, .595 1, .00 55. .95 1SG3053
ATOM 3053 C SER 392 52. .459 28, .997 35, .782 1. .00 55. .95 1SG3054
ATOM 3054 O SER 392 53, .474 29, .659 35. .578 1, .00 55. .95 1SG3055
ATOM 3055 N ASN 393 51, .693 28, .523 34, .783 1, .00 52. .47 1SG3056
ATOM 3056 CA ASN 393 52, .086 28, .756 33 .425 1, .00 52. .47 1SG3057
ATOM 3057 CB ASN 393 51. .373 27. .844 32, .412 1, .00 52. .47 1SG3058
ATOM 3058 CG ASN 393 51, .878 26, .422 32, .615 1, .00 52. .47 1SG3059
ATOM 3059 ODl ASN 393 53 .079 26, .189 32 .747 1, .00 52. .47 1SG3060
ATOM 3060 ND2 ASN 393 50, .935 25, .443 32, .646 1, .00 52. .47 1SG3061
ATOM 3061 C ASN 393 51, .767 30, .170 33, .062 1, .00 52, .47 1SG3062
ATOM 3062 O ASN 393 50. .703 30. .690 33, .392 1. .00 52. .47 1SG3063
ATOM 3063 N ILE 394 52. .716 30. .831 32, .371 1. .00 49. .08 1SG3064
ATOM 3064 CA ILE 394 52. .530 32. .175 31, .914 1, .00 49. .08 1SG3065
ATOM 3065 CB ILE 394 53. .108 33. .214 32. .824 1. .00 49. .08 1SG3066 ATOM 3066 CG2 ILE 394 54..639 33,.075 32..796 1..00 49,.08 1SG3067
ATOM 3067 CGI ILE 394 52. .597 34. .603 32. .412 1. .00 49, .08 1SG3068
ATOM 3068 CDl ILE 394 51, .097 34, .790 32, .637 1. .00 49 .08 1SG3069
ATOM 3069 C ILE 394 53, .222 32, .303 30, .595 1. .00 49, .08 1SG3070
ATOM 3070 O ILE 394 53, .972 31, .418 30. .183 1. .00 49, .08 1SG3071
ATOM 3071 N GLU 395 52, .968 33 .413 29. .875 1, .00 44 .73 1SG3072
ATOM 3072 CA GLU 395 53, .621 33. .576 28. .610 1. .00 44, .73 1SG3073
ATOM 3073 CB GLU 395 53 .091 34 .763 27, .787 1 .00 44 .73 1SG3074
ATOM 3074 CG GLU 395 51, .675 34. .552 27, .249 1. .00 44, .73 1SG3075
ATOM 3075 CD GLU 395 50. .712 34. .595 28, .426 1. .00 44. .73 1SG3076
ATOM 3076 OEl GLU 395 50 .342 35. .723 28 .847 1. .00 44\ .73 1SG3077
ATOM 3077 OE2 GLU 395 50. .339 33, .499 28, .924 1, .00 44. .73 1SG3078
ATOM 3078 C GLU 395 55 .074 33 .816 28, .882 1 .00 44 .73 1SG3079
ATOM 3079 O GLU 395 55 .456 34, .758 29, .574 1, .00 44 .73 1SG3080
ATOM 3080 N VAL 396 55. .926 32. .952 28. .306 1. .00 44. .97 1SG3081
ATOM 3081 CA VAL 396 57 .352 33. .008 28. .469 1, .00 44 .97 1SG3082
ATOM 3082 CB VAL 396 58, .084 31, .859 27, .833 1, .00 44, .97 1SG3083
ATOM 3083 CGI VAL 396 57 .606 30 .555 28 .486 1 .00 44 .97 1SG3084
ATOM 3084 CG2 VAL 396 57, .894 31, .909 26, .310 1, .00 44 .97 1SG3085
ATOM 3085 C VAL 396 57, .856 34, .266 27, .837 1, .00 44, .97 1SG3086
ATOM 3086 O VAL 396 58 .942 34 .741 28 .165 1 .00 44 .97 1SG3087
ATOM 3087 N LEU 397 57. .080 34. .803 26. .878 1, .00 43, .35 1SG3088
ATOM 3088 CA LEU 397 57, .405 35 .958 26 .085 1 .00 43 .35 1SG3089
ATOM 3089 CB LEU 397 56, .356 36 .245 24, .997 1, .00 43 .35 1SG3090
ATOM 3090 CG LEU 397 56, .275 35. .148 23, .920 1, .00 43, .35 1SG3091
ATOM 3091 CD2 LEU 397 55, .413 35 .598 22, .730 1, .00 43 .35 1SG3092
ATOM 3092 CDl LEU 397 55, .818 33 .807 24, .516 1, .00 43, .35 1SG3093
ATOM 3093 C LEU 397 57 .533 37 .199 26 .923 1, .00 43 .35 1SG3094
ATOM 3094 o LEU 397 58, .263 38 .116 26, .554 1, .00 43, .35 1SG3095
ATOM 3095 N ARG 398 56, .811 37. .287 28, .054 1, .00 41, .27 1SG3096
ATOM 3096 CA ARG 398 56 .796 38 .480 28 .860 1, .00 41 .27 1SG3097
ATOM 3097 CB ARG 398 55, .854 38. .356 30, .071 1, .00 41, .27 1SG3098
ATOM 3098 CG ARG 398 54 .385 38 .224 29 .658 1 .00 41 .27 1SG3099
ATOM 3099 CD ARG 398 53, .406 38. .099 30, .827 1, .00 41, .27 1SG3100
ATOM 3100 NE ARG 398 52. .036 37. .983 30, .252 1. .00 41, .27 1SG3101
ATOM 3101 CZ ARG 398 50, .957 37 .831 31 .075 1, .00 41 .27 1SG3102
ATOM 3102 NHl ARG 398 51. .130 37, .791 32, .428 1, .00 41, .27 1SG3103
ATOM 3103 NH2 ARG 398 49. .704 37, .718 30 .545 1 .00 41, .27 1SG3104
ATOM 3104 C ARG 398 58, .178 38, .815 29, .357 1, .00 41 .27 1SG3105
ATOM 3105 0 ARG 398 58, .502 39, .987 29, .542 1, .00 41, .27 1SG3106
ATOM 3106 N PHE 399 59, .008 37, .789 29, .612 1, .00 43 .69 1SG3107
ATOM 3107 CA PHE 399 60. .352 37, .869 30. .129 1, .00 43, .69 1SG3108
ATOM 3108 CB PHE 399 60, .921 36, .493 30. .515 1, .00 43 , .69 1SG3109
ATOM 3109 CG PHE 399 60, .099 35, .939 31, .629 1, .00 43, .69 1SG3110
ATOM 3110 CDl PHE 399 58. .921 35. .280 31. .363 1. .00 43. .69 1SG3111
ATOM 3111 CD2 PHE 399 60. .509 36, .068 32. .936 1. .00 43, .69 1SG3112
ATOM 3112 CE1 PHE 399 58. .160 34. .763 32. .385 1. .00 43. .69 1SG3113
ATOM 3113 CE2 PHE 399 59, .752 35. .552 33, .962 1. .00 43. .69 1SG3114
ATOM 3114 CZ PHE 399 58. .575 34, .898 33, .688 1. .00 43. .69 1SG3115
ATOM 3115 C PHE 399 61. .303 38. .459 29. .127 1. .00 43. .69 1SG3116
ATOM 3116 0 PHE 399 62. .374 38, .931 29. .498 1, .00 43. .69 1SG3117
ATOM 3117 N GLU 400 60. .977 38. .404 27. .825 1. .00 46. .08 1SG3118
ATOM 3118 CA GLU 400 61. .925 38, .772 26. .810 1. .00 46. .08 1SG3119
ATOM 3119 CB GLU 400 61. .331 38. .719 25. .394 1. .00 46. .08 1SG3120
ATOM 3120 CG GLU 400 60. ,965 37. .298 24. .966 1. ,00 46. .08 1SG3121
ATOM 3121 CD GLU 400 60. ,465 37. .352 23. .533 1. .00 46. .08 1SG3122
ATOM 3122 OEl GLU 400 60. ,569 38. .446 22. ,917 1. ,00 46. .08 1SG3123 ATOM 3123 OE2 GLU 400 59..980 36..302 23..031 1..00 46..08 1SG3124
ATOM 3124 C GLU 400 62. .494 40. .142 27. .025 1. .00 46. ,08 1SG3125
ATOM 3125 O GLU 400 63. .698 40. .329 26. .863 1. .00 46. ,08 1SG3126
ATOM 3126 N ASN 401 61. .675 41. .142 27. .395 1, .00 50. .37 1SG3127
ATOM 3127 CA ASN 401 62. .217 42. .462 27. .558 1. .00 50. .37 1SG3128
ATOM 3128 CB ASN 401 61. .130 43. .519 27. .851 1. .00 50. .37 1SG3129
ATOM 3129 CG ASN 401 60. .361 43. .128 29. .106 1. .00 50. .37 1SG3130
ATOM 3130 ODl ASN 401 60, .100 41. .952 29. .354 1, .00 50. .37 1SG3131
ATOM 3131 ND2 ASN 401 59, .968 44. .144 29, .920 1. .00 50. .37 1SG3132
ATOM 3132 C ASN 401 63 .242 42. .474 28 .654 1. .00 50. .37 1SG3133
ATOM 3133 O ASN 401 64 .307 43. .071 28, .503 1. .00 50. .37 1SG3134
ATOM 3134 N ILE 402 62, .966 41. .821 29 .797 1, .00 53 , .86 1SG3135
ATOM 3135 CA ILE 402 63, .935 41. .852 30, .850 1, .00 53. .86 1SG3136
ATOM 3136 CB ILE 402 63, .420 41. .389 32, .185 1. .00 53. .86 1SG3137
ATOM 3137 CG2 ILE 402 62 .205 42, .263 32 .505 1. .00 53, .86 1SG3138
ATOM 3138 CGI ILE 402 63 .116 39, .895 32 .234 1. .00 53, .86 1SG3139
ATOM 3139 CDl ILE 402 64 .387 39. .088 32 .463 1, .00 53, .86 1SG3140
ATOM 3140 C ILE 402 65 .144 41. .077 30, .423 1. .00 53, .86 1SG3141
ATOM 3141 O ILE 402 66, .271 41. .503 30, .656 1. .00 53 , .86 1SG3142
ATOM 3142 N LEU 403 64, .950 39. .922 29. .756 1. .00 51, .23 1SG3143
ATOM 3143 CA LEU 403 66 .068 39 .123 29 .334 1 .00 51 .23 1SG3144
ATOM 3144 CB LEU 403 65 .687 37. .793 28 .646 1, .00 51, .23 1SG3145
ATOM 3145 CG LEU 403 65 .288 36. .651 29 .606 1, .00 51, .23 1SG3146
ATOM 3146 CD2 LEU 403 65, .139 35. .325 28 .846 1, .00 51, .23 1SG3147
ATOM 3147 CDl LEU 403 64. .044 36. .978 30. .438 1, .00 51, .23 1SG3148
ATOM 3148 C LEU 403 66. .910 39. .906 28. .378 1, .00 51, .23 1SG3149
ATOM 3149 O LEU 403 68 .129 39 .750 28 .352 1 .00 51 .23 1SG3150
ATOM 3150 N SER 404 66 .289 40. .752 27 .541 1. .00 48, .27 1SG3151
ATOM 3151 CA SER 404 67 .053 41, .484 26 .574 1, .00 48, .27 1SG3152
ATOM 3152 CB SER 404 66 .186 42, .282 25 .583 1, .00 48, .27 1SG3153
ATOM 3153 OG SER 404 65, .523 43, .347 26, .248 1, .00 48, .27 1SG3154
ATOM 3154 C SER 404 67 .974 42 .449 27 .251 1 .00 48, .27 1SG3155
ATOM 3155 O SER 404 69 .050 42 .724 26 .731 1, .00 48, .27 1SG3156
ATOM 3156 N SER 405 67 .558 43, .047 28 .385 1, .00 45, .28 1SG3157
ATOM 3157 CA SER 405 68 .401 43, .987 29 .077 1. .00 45, .28 1SG3158
ATOM 3158 CB SER 405 67 .622 44. .864 30 .071 1, .00 45, .28 1SG3159
ATOM 3159 OG SER 405 68, .506 45. .765 30, .721 1. .00 45, .28 1SG3160
ATOM 3160 C SER 405 69 .484 43 .300 29 .861 1, .00 45, .28 1SG3161
ATOM 3161 O SER 405 70 .668 43, .591 29 .698 1, .00 45, .28 1SG3162
ATOM 3162 N ILE 406 69 .090 42, .346 30 .728 1, .00 45, .36 1SG3163
ATOM 3163 CA ILE 406 69 .992 41, .725 31 .657 1, .00 45, .36 1SG3164
ATOM 3164 CB ILE 406 69, .293 40. .724 32, .533 1. .00 45, .36 1SG3165
ATOM 3165 CG2 ILE 406 70, .355 39. .773 33, .099 1, .00 45. .36 1SG3166
ATOM 3166 CGI ILE 406 68 .442 41, .434 33 .608 1, .00 45, .36 1SG3167
ATOM 3167 CDl ILE 406 67 .297 42, .288 33 .070 1, .00 45, .36 1SG3168
ATOM 3168 C ILE 406 71, .116 41, .039 30 .959 1, .00 45. .36 1SG3169
ATOM 3169 O ILE 406 72, .274 41, .229 31 .330 1. .00 45. .36 1SG3170
ATOM 3170 N LEU 407 70, .832 40. .234 29, .924 1. .00 47. .27 1SG3171
ATOM 3171 CA LEU 407 71 .919 39. .518 29 .326 1, .00 47. .27 1SG3172
ATOM 3172 CB LEU 407 71 .466 38, .526 28 .239 1. .00 47. .27 1SG3173
ATOM 3173 CG LEU 407 70 .741 37, .290 28 .807 1. .00 47. .27 1SG3174
ATOM 3174 CD2 LEU 407 70. .504 36, .234 27, .717 1. .00 47. .27 1SG3175
ATOM 3175 CDl LEU 407 69. .456 37. .673 29, .557 1. .00 47. .27 1SG3176
ATOM 3176 C LEU 407 72. .938 40. .442 28. .723 1. .00 47. .27 1SG3177
ATOM 3177 O LEU 407 74 .123 40. .352 29 .033 1. .00 47. .27 1SG3178
ATOM 3178 N HIS 408 72. .528 41. .384 27, .861 1. .00 50. .51 1SG3179
ATOM 3179 CA HIS 408 73. .526 42. .196 27, .225 1. .00 50. ,51 1SG3180 ATOM 3180 NDl HIS 408 74..746 43..337 24.,336 1.00 50..51 1SG3181
ATOM 3181 CG HIS 408 74. .038 43, .856 25. ,397 1. .00 50. .51 1SG3182
ATOM 3182 CB HIS 408 72. .960 43, .112 26. .128 1. ,00 50. .51 1SG3183
ATOM 3183 NE2 HIS 408 75. .541 45, .384 24. .690 1. .00 50. .51 1SG3184
ATOM 3184 CD2 HIS 408 74. .536 45, .107 25. .600 1. .00 50. .51 1SG3185
ATOM 3185 CE1 HIS 408 75 .631 44, .292 23. ,952 1. .00 50. .51 1SG3186
ATOM 3186 C HIS 408 74. .224 43 .070 28. .216 1. .00 50. .51 1SG3187
ATOM 3187 O HIS 408 75. .439 43, .230 28. .150 1. .00 50, .51 1SG3188
ATOM 3188 N PHE 409 73, .479 43. .724 29. .125 1. .00 53, .53 1SG3189
ATOM 3189 CA PHE 409 74 .146 44. .604 30. .039 1. .00 53 .53 1SG3190
ATOM 3190 CB PHE 409 73, .170 45, .532 30. .788 1. .00 53. .53 1SG3191
ATOM 3191 CG PHE 409 73, .971 46, .440 31. .662 1. .00 53, .53 1SG3192
ATOM 3192 CDl PHE 409 74, .332 46, .063 32. .936 1. .00 53, .53 1SG3193
ATOM 3193 CD2 PHE 409 74 .362 47 .677 31, .203 1. .00 53 .53 1SG3194
ATOM 3194 CE1 PHE 409 75, .070 46. .904 33. .736 1. .00 53, .53 1SG3195
ATOM 3195 CE2 PHE 409 75 .100 48 .522 31. .998 1. .00 53 .53 1SG3196
ATOM 3196 CZ PHE 409 75 .456 48 .137 33. .267 1. .00 53 .53 1SG3197
ATOM 3197 C PHE 409 74, .940 43, .862 31. .074 1. .00 53, .53 1SG3198
ATOM 3198 0 PHE 409 76, .116 44, .154 31. .276 1, .00 53 .53 1SG3199
ATOM 3199 N GLY 410 74, .290 42 .942 31. .819 1. .00 52 .81 1SG3200
ATOM 3200 CA GLY 410 74 .961 42 .247 32, .885 1 .00 52 .81 1SG3201
ATOM 3201 C GLY 410 75. .856 41 .104 32, .497 1. .00 52 .81 1SG3202
ATOM 3202 O GLY 410 77, .016 41 .065 32, .903 1. .00 52 .81 1SG3203
ATOM 3203 N VAL 411 75, .314 40 .104 31, .762 1. .00 52 .99 1SG3204
ATOM 3204 CA VAL 411 76, .058 38, .897 31. .507 1. .00 52 .99 1SG3205
ATOM 3205 CB VAL 411 75. .200 37 .671 31. .313 1. .00 52 .99 1SG3206
ATOM 3206 CGI VAL 411 74 .480 37 .393 32, .640 1 .00 52 .99 1SG3207
ATOM 3207 CG2 VAL 411 74, .226 37 .865 30 .151 1 .00 52 .99 1SG3208
ATOM 3208 C VAL 411 77, .110 38 .958 30, .438 1, .00 52 .99 1SG3209
ATOM 3209 0 VAL 411 78, .234 38 .506 30 .650 1, .00 52 .99 1SG3210
ATOM 3210 N LEU 412 76 .803 39 .528 29, .262 1 .00 49 .17 1SG3211
ATOM 3211 CA LEU 412 77. .743 39 .466 28, .177 1, .00 49 .17 1SG3212
ATOM 3212 CB LEU 412 77. .234 40 .091 26, .868 1. .00 49 .17 1SG3213
ATOM 3213 CG LEU 412 78, .213 39 .862 25 .700 1 .00 49 .17 1SG3214
ATOM 3214 CD2 LEU 412 77, .851 40 .707 24 .473 1, .00 49 .17 1SG3215
ATOM 3215 CDl LEU 412 78. .330 38, .367 25, .366 1. .00 49 .17 1SG3216
ATOM 3216 C LEU 412 79. .027 40 .154 28, .530 1, .00 49 .17 1SG3217
ATOM 3217 0 LEU 412 80, .093 39 .634 28 .203 1 .00 49 .17 1SG3218
ATOM 3218 N PRO 413 79. .005 41, .278 29. .191 1. .00 45 .47 1SG3219
ATOM 3219 CA PRO 413 80. .235 41, .964 29. .447 1. .00 45 .47 1SG3220
ATOM 3220 CD PRO 413 77, .888 42 .206 29, .109 1, .00 45 .47 1SG3221
ATOM 3221 CB PRO 413 79, .843 43 .306 30 .057 1 .00 45 .47 1SG3222
ATOM 3222 CG PRO 413 78. .477 43, .596 29, .406 1. .00 45, .47 1SG3223
ATOM 3223 C PRO 413 81. .238 41, .184 30, .229 1. .00 45, .47 1SG3224
ATOM 3224 0 PRO 413 82. .429 41 .348 29, .972 1, .00 45, .47 1SG3225
ATOM 3225 N LEU 414 80. .809 40. .349 31. .191 1. .00 42, .19 1SG3226
ATOM 3226 CA LEU 414 81. .775 39 .615 31, .949 1. .00 42, .19 1SG3227
ATOM 3227 CB LEU 414 81. .171 38. .916 33, .189 1, .00 42, .19 1SG3228
ATOM 3228 CG LEU 414 80. .237 37 .717 32, .920 1, .00 42. .19 1SG3229
ATOM 3229 CD2 LEU 414 79. .305 37. .465 34. .116 1, .00 42. .19 1SG3230
ATOM 3230 CDl LEU 414 81. .018 36. .459 32. .507 1. .00 42. .19 1SG3231
ATOM 3231 C LEU 414 82, .436 38 .604 31. .061 1. .00 42, .19 1SG3232
ATOM 3232 O LEU 414 83. .647 38. .405 31. .132 1. .00 42. .19 1SG3233
ATOM 3233 N ALA 415 81. .647 37. .939 30. .193 1. .00 38. .20 1SG3234
ATOM 3234 CA ALA 415 82. .156 36. .890 29. .356 1, .00 38, .20 1SG3235
ATOM 3235 CB ALA 415 81. ,052 36. .214 28, .525 1. .00 38, .20 1SG3236
ATOM 3236 C ALA 415 83. ,173 37. .408 28, .391 1. .00 38, .20 1SG3237 ATOM 3237 O ALA 415 84,.250 36..832 28..242 1..00 38,.20 1SG3238
ATOM 3238 N ASN 416 82, .870 38. .526 27, .713 1. .00 37, .38 1SG3239
ATOM 3239 CA ASN 416 83, .795 39. .033 26. .748 1. .00 37, .38 1SG3240
ATOM 3240 CB ASN 416 83, .210 39. .970 25. .668 1. ,00 37, .38 1SG3241
ATOM 3241 CG ASN 416 82, .264 40. .988 26. .261 1. ,00 37, .38 1SG3242
ATOM 3242 ODl ASN 416 81 .056 40. .782 26, .158 1. .00 37 .38 1SG3243
ATOM 3243 ND2 ASN 416 82 .787 42. .083 26, .871 1. .00 37 .38 1SG3244
ATOM 3244 C ASN 416 85 .033 39. .565 27, .390 1. .00 37 .38 1SG3245
ATOM 3245 O ASN 416 86 .060 39, .694 26. .729 1. .00 37 .38 1SG3246
ATOM 3246 N ALA 417 84 .984 39, .907 28, .689 1. .00 35 .15 1SG3247
ATOM 3247 CA ALA 417 86 .169 40, .405 29, .325 1. .00 35, .15 1SG3248
ATOM 3248 CB ALA 417 85 .952 40, .732 30, .813 1. .00 35, .15 1SG3249
ATOM 3249 C ALA 417 87, .229 39, .347 29, .246 1. .00 35, .15 1SG3250
ATOM 3250 O ALA 417 88 .384 39. .650 28, .949 1. .00 35, .15 1SG3251
ATOM 3251 N LYS 418 86, .871 38. .074 29, .517 1. .00 34, .75 1SG3252
ATOM 3252 CA LYS 418 87, .839 37. .017 29. .435 1. .00 34, .75 1SG3253
ATOM 3253 CB LYS 418 87, .346 35. .660 29, .965 1. .00 34, .75 1SG3254
ATOM 3254 CG LYS 418 88 .383 34. .553 29, .757 1. .00 34 .75 1SG3255
ATOM 3255 CD LYS 418 89 .704 34. .786 30 .495 1, .00 34 .75 1SG3256
ATOM 3256 CE LYS 418 90 .803 33. .797 30, .097 1. .00 34 .75 1SG3257
ATOM 3257 NZ LYS 418 92 .073 34. .146 30, .771 1, .00 34 .75 1SG3258
ATOM 3258 C LYS 418 88 .255 36. .816 28, .009 1. .00 34 .75 1SG3259
ATOM 3259 O LYS 418 89 .431 36, .603 27, .721 1. .00 34 .75 1SG3260
ATOM 3260 N LEU 419 87 .290 36, .892 27, .079 1. .00 34 .34 1SG3261
ATOM 3261 CA LEU 419 87 .539 36, .677 25, .681 1. .00 34 .34 1SG3262
ATOM 3262 CB LEU 419 86 .275 36, .874 24, .830 1. .00 34 .34 1SG3263
ATOM 3263 CG LEU 419 85, .131 35. .895 25, .161 1. .00 34, .34 1SG3264
ATOM 3264 CD2 LEU 419 85 .612 34. .438 25, .114 1. .00 34, .34 1SG3265
ATOM 3265 CDl LEU 419 83 .903 36 .149 24 .270 1. .00 34 .34 1SG3266
ATOM 3266 C LEU 419 88 .527 37. .706 25 .236 1. .00 34 .34 1SG3267
ATOM 3267 O LEU 419 89 .420 37. .429 24 .436 1, .00 34 .34 1SG3268
ATOM 3268 N GLN 420 88 .367 38, .939 25, .744 1. .00 33 .94 1SG3269
ATOM 3269 CA GLN 420 89 .233 40, .034 25. .424 1. .00 33 .94 1SG3270
ATOM 3270 CB GLN 420 88, .772 41, .360 26. .052 1. .00 33 .94 1SG3271
ATOM 3271 CG GLN 420. 89, .679 42, .548 25, .722 1. .00 33 .94 1SG3272
ATOM 3272 CD GLN 420 89, .449 42 , .931 24, .269 1. .00 33, .94 1SG3273
ATOM 3273 OEl GLN 420 90, .394 43 , .172 23, .519 1. .00 33, .94 1SG3274
ATOM 3274 NE2 GLN 420 88, .155 42. .999 23, .859 1. .00 33, .94 1SG3275
ATOM 3275 C GLN 420 90, .595 39. .734 25, .964 1. .00 33, .94 1SG3276
ATOM 3276 O GLN 420 91 .599 40. .105 25 .359 1. .00 33, .94 1SG3277
ATOM 3277 N GLN 421 90 .670 39. .072 27, .137 1. .00 34, .21 1SG3278
ATOM 3278 CA GLN 421 91, .957 38. .778 27, .692 1. .00 34, .21 1SG3279
ATOM 3279 CB GLN 421 91, .889 38, .040 29, .038 1. .00 34. .21 1SG3280
ATOM 3280 CG GLN 421 93. .267 37, .819 29, .662 1. .00 34, .21 1SG3281
ATOM 3281 CD GLN 421 93, .801 39, .177 30, .099 1. .00 34, .21 1SG3282
ATOM 3282 OEl GLN 421 94. .937 39. .297 30, .555 1. .00 34, .21 1SG3283
ATOM 3283 NE2 GLN 421 92. .957 40. .235 29, .954 1. .00 34, .21 1SG3284
ATOM 3284 C GLN 421 92. .645 37. .887 26. .712 1. ,00 34. .21 1SG3285
ATOM 3285 O GLN 421 93. .822 38. .071 26. .407 1. .00 34. .21 1SG3286
ATOM 3286 N GLY 422 91. .901 36. .902 26. .174 1. .00 35. .65 1SG3287
ATOM 3287 CA GLY 422 92. .421 36. .064 25. .134 1. 00 35. .65 1SG3288
ATOM 3288 C GLY 422 93. .079 34. .844 25, .685 1. .00 35. .65 1SG3289
ATOM 3289 O GLY 422 93. .077 34. .591 26, .889 1. ,00 35. .65 1SG3290
ATOM 3290 N PHE 423 93. .643 34. .043 24. .756 1. ,00 39. .98 1SG3291
ATOM 3291 CA PHE 423 94. .333 32. .834 25. .079 1. ,00 39. .98 1SG3292
ATOM 3292 CB PHE 423 93. .684 31. ,574 24. .480 1. 00 39. .98 1SG3293
ATOM 3293 CG PHE 423 92. .319 31. ,463 25. ,064 1. 00 39. .98 1SG3294 ATOM 3294 CDl PHE 423 92..148 31..091 26..378 1..00 39..98 1SG3295
ATOM 3295 CD2 PHE 423 91. ,207 31. .714 24. .293 1. 00 39. .98 1SG3296
ATOM 3296 CE1 PHE 423 90. .887 30. .986 26. .915 1. .00 39. .98 1SG3297
ATOM 3297 CE2 PHE 423 89. .944 31. .610 24. .825 1. .00 39. .98 1SG3298
ATOM 3298 CZ PHE 423 89. .782 31. .247 26. .140 1. .00 39. .98 1SG3299
ATOM 3299 C PHE 423 95. .697 32. .959 24. .482 1. .00 39. .98 1SG3300
ATOM 3300 O PHE 423 95. .885 33. .611 23. .457 1. ,00 39. .98 1SG3301
ATOM 3301 N PRO 424 96. .661 32. .369 25. .125 1. ,00 44. .05 1SG3302
ATOM 3302 CA PRO 424 98. .007 32. .459 24. .628 1. .00 44, .05 1SG3303
ATOM 3303 CD PRO 424 96. .625 32. .314 26. .577 1. .00 44. .05 1SG3304
ATOM 3304 CB PRO 424 98. .908 32. .043 25. .788 1. ,00 44. .05 1SG3305
ATOM 3305 CG PRO 424 98. .089 32. .432 27, .032 1. .00 44. .05 1SG3306
ATOM 3306 C PRO 424 98. .216 31. .664 23. .378 1. .00 44. .05 1SG3307
ATOM 3307 O PRO 424 97. .656 30. .574 23. .264 1. .00 44. .05 1SG3308
ATOM 3308 N LEU 425 99. .032 32. .187 22, .436 1, .00 48. .63 1SG3309
ATOM 3309 CA LEU 425 99. .321 31. .480 21, .219 1. .00 48. .63 1SG3310
ATOM 3310 CB LEU 425 99. .366 32. .352 19, .949 1. .00 48, .63 1SG3311
ATOM 3311 CG LEU 425 97, .976 32. .755 19, .422 1, .00 48 .63 1SG3312
ATOM 3312 CD2 LEU 425 98. .073 33, .411 18, .036 1, .00 48, .63 1SG3313
ATOM 3313 CDl LEU 425 97. .210 33. .611 20, .438 1. .00 48, .63 1SG3314
ATOM 3314 C LEU 425 100. .652 30. .818 21 .380 1. .00 48 .63 1SG3315
ATOM 3315 O LEU 425 101. .480 31. .254 22, .178 1, .00 48 .63 1SG3316
ATOM 3316 N PRO 426 100. .856 29. .714 20, .709 1. .00 49, .78 1SG3317
ATOM 3317 CA PRO 426 102, .102 29, .007 20 .789 1, .00 49 .78 1SG3318
ATOM 3318 CD PRO 426 99, .821 28 , .971 20, .015 1, .00 49 .78 1SG3319
ATOM 3319 CB PRO 426 101. .856 27. .655 20, .119 1. .00 49, .78 1SG3320
ATOM 3320 CG PRO 426 100. .599 27. .882 19 .255 1, .00 49 .78 1SG3321
ATOM 3321 C PRO 426 103 , .206 29. .792 20 .168 1, .00 49 .78 1SG3322
ATOM 3322 O PRO 426 103. .521 29. .543 19, .005 1, .00 49 .78 1SG3323
ATOM 3323 N ASN 427 103, .871 30. .670 20 .940 1, .00 48 .49 1SG3324
ATOM 3324 CA ASN 427 104 , .917 31. .468 20, .372 1, .00 48 .49 1SG3325
ATOM 3325 CB ASN 427 104. .642 32. .974 20, .468 1, .00 48 .49 1SG3326
ATOM 3326 CG ASN 427 103, .302 33. .238 19 .812 1 .00 48 .49 1SG3327
ATOM 3327 ODl ASN 427 102 , .886 32. .514 18. .910 1, .00 48 .49 1SG3328
ATOM 3328 ND2 ASN 427 102. .599 34. .296 20, .299 1, .00 48 .49 1SG3329
ATOM 3329 C ASN 427 106. .119 31. .249 21 .223 1 .00 48 .49 1SG3330
ATOM 3330 O ASN 427 106. .023 31. .158 22 .445 1, .00 48 .49 1SG3331
ATOM 3331 N PRO 428 107. .252 31. .172 20, .595 1, .00 47 .84 1SG3332
ATOM 3332 CA PRO 428 108. .492 31. .023 21 .301 1 .00 47 .84 1SG3333
ATOM 3333 CD PRO 428 107. .347 30, .729 19, .216 1. .00 47 .84 1SG3334
ATOM 3334 CB PRO 428 109. .517 30. .551 20, .267 1, .00 47 .84 1SG3335
ATOM 3335 CG PRO 428 108. .850 30, .815 18 .906 1 .00 47 .84 1SG3336
ATOM 3336 C PRO 428 108. .800 32, .347 21 .917 1, .00 47 .84 1SG3337
ATOM 3337 O PRO 428 108. .112 33. .315 21, .605 1, .00 47, .84 1SG3338
ATOM 3338 N HIS 429 109, .803 32, .405 22 .810 1, .00 47 .45 1SG3339
ATOM 3339 CA HIS 429 110. .151 33. .614 23, .498 1, .00 47 .45 1SG3340
ATOM 3340 NDl HIS 429 112. .394 35. .591 25, .050 1. .00 47, .45 1SG3341
ATOM 3341 CG HIS 429 111. .475 34, .634 25, .417 1. .00 47 .45 1SG3342
ATOM 3342 CB HIS 429 111. .181 33, .396 24, .622 1. .00 47, .45 1SG3343
ATOM 3343 NE2 HIS 429 111. .519 36. .261 26, .981 1. .00 47, .45 1SG3344
ATOM 3344 CD2 HIS 429 110. .949 35. .060 26, .599 1, .00 47 .45 1SG3345
ATOM 3345 CE1 HIS 429 112. .380 36. .540 26, .019 1, .00 47, .45 1SG3346
ATOM 3346 C HIS 429 110. .738 34. .593 22, .529 1. .00 47. .45 1SG3347
ATOM 3347 O HIS 429 111. .191 34. .220 21, .449 1, .00 47 .45 1SG3348
ATOM 3348 N LYS 430 110. .703 35. .889 22, .906 1. .00 49 .66 1SG3349
ATOM 3349 CA LYS 430 111. .263 36. .992 22. .166 1. .00 49. .66 1SG3350
ATOM 3350 CB LYS 430 112. .808 37. .017 22. .162 1, .00 49 .66 1SG3351 ATOM 3351 CG LYS 430 113..493 35.710 21.,752 1.,00 49..66 1SG3352
ATOM 3352 CD LYS 430 113. .390 35. ,353 20. .268 1. ,00 49. .66 1SG3353
ATOM 3353 CE LYS 430 114. ,010 33. .991 19. .945 1. ,00 49. ,66 1SG3354
ATOM 3354 NZ LYS 430 113. .705 33. ,613 18. .547 1. .00 49. .66 1SG3355
ATOM 3355 C LYS 430 110. ,747 37. ,061 20. .764 1. ,00 49. .66 1SG3356
ATOM 3356 O LYS 430 111. .497 37. .333 19. .827 1. .00 49. .66 1SG3357
ATOM 3357 N PHE 431 109. ,431 36. .846 20. ,590 1. .00 50. .51 1SG3358
ATOM 3358 CA PHE 431 108. .818 36. .931 19. .295 1. .00 50. .51 1SG3359
ATOM 3359 CB PHE 431 108. .500 35. .539 18. .728 1. .00 50. .51 1SG3360
ATOM 3360 CG PHE 431 107. .332 35. .688 17, .828 1, .00 50. .51 1SG3361
ATOM 3361 CDl PHE 431 107. .453 36. .220 16. .568 1. .00 50. .51 1SG3362
ATOM 3362 CD2 PHE 431 106, .098 35. .275 18. .276 1. .00 50. .51 1SG3363
ATOM 3363 CE1 PHE 431 106. .338 36. .337 15. .775 1. .00 50. .51 1SG3364
ATOM 3364 CE2 PHE 431 104. .985 35, .391 17, .483 1. .00 50. .51 1SG3365
ATOM 3365 CZ PHE 431 105, .110 35. .926 16, .227 1. .00 50. .51 1SG3366
ATOM 3366 C PHE 431 107. .526 37. .678 19. .425 1. .00 50. .51 1SG3367
ATOM 3367 O PHE 431 106. .840 37. .575 20, .439 1. .00 50. .51 1SG3368
ATOM 3368 N LEU 432 107. .173 38. .475 18. .394 1, .00 48. .57 1SG3369
ATOM 3369 CA LEU 432 105, .924 39. .184 18. .402 1. .00 48. .57 1SG3370
ATOM 3370 CB LEU 432 106, .023 40. .684 18. .759 1. .00 48. .57 1SG3371
ATOM 3371 CG LEU 432 107 .006 41, .521 17 .916 1 .00 48 .57 1SG3372
ATOM 3372 CD2 LEU 432 108, .436 40, .959 17. .979 1. .00 48, .57 1SG3373
ATOM 3373 CDl LEU 432 106 .972 42, .997 18 .346 1 .00 48 .57 1SG3374
ATOM 3374 C LEU 432 105, .319 39. .063 17. .035 1. .00 48 .57 1SG3375
ATOM 3375 O LEU 432 106 .032 39. .049 16 .033 1 .00 48 .57 1SG3376
ATOM 3376 N PHE 433 103, .973 38, .964 16. .968 1. .00 45 .17 1SG3377
ATOM 3377 CA PHE 433 103 .269 38 .806 15 .720 1 .00 45 .17 1SG3378
ATOM 3378 CB PHE 433 101 .932 38, .044 15, .812 1. .00 45 .17 1SG3379
ATOM 3379 CG PHE 433 102, .103 36. .591 16, .060 1. .00 45 .17 1SG3380
ATOM 3380 CDl PHE 433 102 .430 35. .742 15 .032 1, .00 45 .17 1SG3381
ATOM 3381 CD2 PHE 433 101, .891 36, .070 17, .311 1, .00 45, .17 1SG3382
ATOM 3382 CE1 PHE 433 102 .578 34, .393 15 .244 1, .00 45 .17 1SG3383
ATOM 3383 CE2 PHE 433 102. .036 34, .722 17, .527 1, .00 45 .17 1SG3384
ATOM 3384 CZ PHE 433 102 .381 33, .878 16 .500 1, .00 45 .17 1SG3385
ATOM 3385 C PHE 433 102, .789 40, .146 15, .261 1, .00 45 .17 1SG3386
ATOM 3386 O PHE 433 102 .284 40 .940 16 .052 1 .00 45 .17 1SG3387
ATOM 3387 N VAL 434 102, .904 40, .412 13, .944 1, .00 39 .53 1SG3388
ATOM 3388 CA VAL 434 102 .419 41 .650 13 .406 1, .00 39 .53 1SG3389
ATOM 3389 CB VAL 434 103 .505 42, .666 13, .199 1, .00 39 .53 1SG3390
ATOM 3390 CGI VAL 434 104 .480 42 .126 12 .139 1 .00 39 .53 1SG3391
ATOM 3391 CG2 VAL 434 102 .862 44 .014 12, .829 1, .00 39 .53 1SG3392
ATOM 3392 C VAL 434 101. .817 41, .359 12, .060 1. .00 39. .53 1SG3393
ATOM 3393 O VAL 434 102 .049 40, .297 11. .485 1, .00 39. .53 1SG3394
ATOM 3394 N ASN 435 101. .018 42, .311 11. .528 1. .00 36, .61 1SG3395
ATOM 3395 CA ASN 435 100 .409 42, .186 10. .229 1. .00 36, .61 1SG3396
ATOM 3396 CB ASN 435 101 .407 42, .343 9. .068 1. .00 36, .61 1SG3397
ATOM 3397 CG ASN 435 101 .859 43, .795 9. .023 1, .00 36 .61 1SG3398
ATOM 3398 ODl ASN 435 101, .184 44. .686 9. .538 1, .00 36, .61 1SG3399
ATOM 3399 ND2 ASN 435 103 .032 44 .046 8 .382 1, .00 36 .61 1SG3400
ATOM 3400 C ASN 435 99, .749 40. .850 10, .090 1. .00 36, .61 1SG3401
ATOM 3401 O ASN 435 100 .154 40 .037 9 .260 1. .00 36 .61 1SG3402
ATOM 3402 N SER 436 98 .702 40, .587 10, .901 1. .00 35, .80 1SG3403
ATOM 3403 CA SER 436 98 .057 39 .305 10 .854 1. .00 35 .80 1SG3404
ATOM 3404 CB SER 436 97 .649 38, .771 12, .238 1. .00 35, .80 1SG3405
ATOM 3405 OG SER 436 97 .015 37 .507 12 .110 1, .00 35 .80 1SG3406
ATOM 3406 C SER 436 96 .814 39, .361 10, .016 1. .00 35. .80 1SG3407
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ATOM 133 O GLN 19 104..366 39..201 13..113 1..00 39..72 ISG 134
ATOM 134 N LEU 20 102. .627 39. .826 14. .405 1. ,00 43. ,05 ISG 135
ATOM 135 CA LEU 20 102. .451 38. .484 14. .876 1. .00 43. ,05 ISG 136
ATOM 136 CB LEU 20 102. .449 38, .357 16, .406 1. .00 43. .05 ISG 137
ATOM 137 CG LEU 20 103. .667 39, .018 17, .072 1. .00 43. .05 ISG 138
ATOM 138 CD2 LEU 20 103. .576 40. .549 16. .987 1. .00 43. ,05 ISG 139
ATOM 139 CDl LEU 20 104. .990 38. .452 16. .532 1. .00 43. ,05 ISG 140
ATOM 140 C LEU 20 101. .104 38. .033 14 , .426 1. .00 43. .05 ISG 141
ATOM 141 O LEU 20 100. .169 38. .827 14 , .344 1. .00 43. .05 ISG 142
ATOM 142 N LEU 21 100. .966 36. .737 14. .094 1. .00 43. .59 ISG 143
ATOM 143 CA LEU 21 99, .662 36. .292 13. .710 1. .00 43. .59 ISG 144
ATOM 144 CB LEU 21 99, .674 35. .485 12, .397 1. .00 43. ,59 ISG 145
ATOM 145 CG LEU 21 98. .327 35. .482 11. .645 1. .00 43. .59 ISG 146
ATOM 146 CD2 LEU 21 98. .114 36, .811 10. .907 1. .00 43. .59 ISG 147
ATOM 147 CDl LEU 21 97, .143 35, .108 12. .545 1. .00 43. .59 ISG 148
ATOM 148 C LEU 21 99, .288 35, .359 14. .822 1. .00 43. .59 ISG 149
ATOM 149 O LEU 21 9 .965 34, .355 15. .032 1, .00 43. .59 ISG 150
ATOM 150 N LEU 22 98 .217 35 .657 15, .587 1. .00 41. .40 ISG 151
ATOM 151 CA LEU 22 97, .930 34. .788 16. .694 1. .00 41. .40 ISG 152
ATOM 152 CB LEU 22 97, .352 35. .518 17, .925 1. .00 41. .40 ISG 153
ATOM 153 CG LEU 22 98. .309 36. .567 18, .537 1, .00 41, .40 ISG 154
ATOM 154 CD2 LEU 22 99 .734 36 .017 18, .693 1. .00 41, .40 ISG 155
ATOM 155 CDl LEU 22 97 .755 37 .135 19 .854 1. .00 41, .40 ISG 156
ATOM 156 C LEU 22 96 .949 33 .758 16 .233 1. .00 41, .40 ISG 157
ATOM 157 O LEU 22 95. .881 34, .069 15, .707 1. .00 41, .40 ISG 158
ATOM 158 N PRO 23 97 .314 32. .519 16, .417 1. .00 37, .97 ISG 159
ATOM 159 CA PRO 23 96. .468 31. .453 15, .952 1. .00 37. .97 ISG 160
ATOM 160 CD PRO 23 98 .722 32 .167 16, .310 1. .00 37, .97 ISG 161
ATOM 161 CB PRO 23 97 .365 30 .225 15, .814 1. .00 37, .97 ISG 162
ATOM 162 CG PRO 23 98 .763 30 .818 15 .577 1. .00 37 .97 ISG 163
ATOM 163 C PRO 23 95 .280 31. .207 16. .823 1. .00 37, .97 ISG 164
ATOM 164 O PRO 23 95 .268 31. .634 17, .977 1. .00 37, .97 ISG 165
ATOM 165 N ALA 24 94 .269 30. .512 16, .268 1. .00 33, .29 ISG 166
ATOM 166 CA ALA 24 93 .071 30. .162 16, .966 1, .00 33, .29 ISG 167
ATOM 167 CB ALA 24 92 .092 29 .362 16, .089 1. .00 33, .29 ISG 168
ATOM 168 C ALA 24 93 .481 29 .285 18, .100 1, .00 33 .29 ISG 169
ATOM 169 O ALA 24 92 .932 29, .364 19. .197 1, .00 33, .29 ISG 170
ATOM 170 N THR 25 94 .490 28, .433 17. .855 1, .00 31, .39 ISG 171
ATOM 171 CA THR 25 94 .951 27. .531 18. .864 1, .00 31, .39 ISG 172
ATOM 172 CB THR 25 96 .105 26. .682 18. .415 1, .00 31, .39 ISG 173
ATOM 173 OGl THR 25 96 .413 25 .718 19. .412 1. .00 31, .39 ISG 174
ATOM 174 CG2 THR 25 97 .325 27 .578 18. .142 1, .00 31, .39 ISG 175
ATOM 175 C THR 25 95, .397 28. .346 20. .037 1. .00 31. .39 ISG 176
ATOM 176 O THR 25 95, .141 27, .983 21. .183 1. .00 31. .39 ISG 177
ATOM 177 N PHE 26 96 .053 29, .492 19. .782 1. .00 29. .20 ISG 178
ATOM 178 CA PHE 26 96 .558 30, .315 20, .843 1. .00 29. .20 ISG 179
ATOM 179 CB PHE 26 97 .175 31. .615 20, .299 1. .00 29, .20 ISG 180
ATOM 180 CG PHE 26 97 .662 32. .450 21, .433 1, .00 29, .20 ISG 181
ATOM 181 CDl PHE 26 98 .925 32 .274 21, .948 1. .00 29, .20 ISG 182
ATOM 182 CD2 PHE 26 96. .851 33. .420 21. .978 1. .00 29. .20 ISG 183
ATOM 183 CE1 PHE 26 99. .370 33, .051 22. .992 1. .00 29. .20 ISG 184
ATOM 184 CE2 PHE 26 97. .290 34, .200 23. .022 1. .00 29. .20 ISG 185
ATOM 185 CZ PHE 26 98. .553 34, .016 23, .530 1. .00 29. .20 ISG 186
ATOM 186 C PHE 26 95 .418 30, .705 21, .733 1. .00 29. .20 ISG 187
ATOM 187 O PHE 26 95 .486 30 .542 22, .950 1. .00 29. .20 ISG 188
ATOM 188 N LEU 27 94, .327 31. .222 21. .137 1. .00 28. , 98 ISG 189
ATOM 189 CA LEU 27 93, .188 31. .657 21. .896 1. ,00 28. .98 ISG 190 ATOM 190 CB LEU 27 92,.102 32,.318 21..026 1..00 28,.98 ISG 191
ATOM 191 CG LEU 27 92, .487 33. .694 20. .448 1. .00 28. .98 ISG 192
ATOM 192 CD2 LEU 27 91, .301 34. .330 19. .703 1. .00 28. .98 ISG 193
ATOM 193 CDl LEU 27 93. .745 33. .609 19. .571 1. .00 28. .98 ISG 194
ATOM 194 C LEU 27 92, .542 30. .487 22. .576 1. .00 28. .98 ISG 195
ATOM 195 O LEU 27 92, .138 30. .582 23, .733 1. .00 28 .98 ISG 196
ATOM 196 N SER 28 92, .428 29, .350 21, .862 1. .00 29, .85 ISG 197
ATOM 197 CA SER 28 91, .755 28, .176 22, .352 1. .00 29 .85 ISG 198
ATOM 198 CB SER 28 91. .706 27, .057 21, .295 1. .00 29, .85 ISG 199
ATOM 199 OG SER 28 91. .042 25, .914 21, .814 1, .00 29 .85 ISG 200
ATOM 200 C SER 28 92. .466 27, .617 23, .541 1. .00 29, .85 ISG 201
ATOM 201 O SER 28 91. .832 27, .145 24, .482 1, .00 29, .85 ISG 202
ATOM 202 N ALA 29 93. .807 27 .668 23, .540 1, .00 29 .09 ISG 203
ATOM 203 CA ALA 29 94, .563 27, .075 24 , .603 1. .00 29, .09 ISG 204
ATOM 204 CB ALA 29 96 .082 27 .234 24, .415 1. .00 29 .09 ISG 205
ATOM 205 C ALA 29 94, .200 27, .740 25, .887 1. .00 29, .09 ISG 206
ATOM 206 O ALA 29 94, .116 27 .091 26, .928 1. .00 29 .09 ISG 207
ATOM 207 N GLU 30 93, .976 29, .063 25. .853 1. .00 29, .57 ISG 208
ATOM 208 CA GLU 30 93, .705 29, .758 27, .073 1. .00 29 .57 ISG 209
ATOM 209 CB GLU 30 93 .549 31 .273 26, .867 1, .00 29 .57 ISG 210
ATOM 210 CG GLU 30 93, .295 32, .043 28, .164 1, .00 29 .57 ISG 211
ATOM 211 CD GLU 30 94 .554 31 .972 29, .019 1. .00 29 .57 ISG 212
ATOM 212 OEl GLU 30 95, .644 32, .363 28, .524 1. .00 29 .57 ISG 213
ATOM 213 OE2 GLU 30 94, .435 31 .516 30, .188 1. .00 29 .57 ISG 214
ATOM 214 C GLU 30 92, .445 29, .235 27, .691 1. .00 29, .57 ISG 215
ATOM 215 O GLU 30 92, .395 28, .990 28, .894 1, .00 29 .57 ISG 216
ATOM 216 N LEU 31 91 .395 29 .026 26, .878 1. .00 28 .21 ISG 217
ATOM 217 CA LEU 31 90, .119 28 .608 27, .384 1. .00 28 .21 ISG 218
ATOM 218 CB LEU 31 89 .030 28 .659 26, .301 1. .00 28 .21 ISG 219
ATOM 219 CG LEU 31 88, .683 30, .108 25, .889 1. ,00 28 .21 ISG 220
ATOM 220 CD2 LEU 31 87 .507 30 .140 24 , .904 1. .00 28 .21 ISG 221
ATOM 221 CDl LEU 31 89, .907 30, .868 25. .350 1. .00 28 .21 ISG 222
ATOM 222 C LEU 31 90, .216 27 .233 27. .978 1. .00 28 .21 ISG 223
ATOM 223 O LEU 31 89 .583 26 .940 28, .993 1. .00 28 .21 ISG 224
ATOM 224 N ALA 32 91, .002 26, .342 27. .348 1. .00 27 .60 ISG 225
ATOM 225 CA ALA 32 91, .157 25 .004 27. .839 1. .00 27 .60 ISG 226
ATOM 226 CB ALA 32 92, .035 24, .144 26. .913 1, .00 27, .60 ISG 227
ATOM 227 C ALA 32 91, .823 25, .055 29. .179 1, .00 27 .60 ISG 228
ATOM 228 O ALA 32 91, .407 24, .376 30. .116 1. .00 27, .60 ISG 229
ATOM 229 N LEU 33 92, .860 25, .903 29. .307 1. .00 29, .43 ISG 230
ATOM 230 CA LEU 33 93 .635 26 .002 30, .511 1. .00 29 .43 ISG 231
ATOM 231 CB LEU 33 94, .757 27, .050 30. .389 1. .00 29, .43 ISG 232
ATOM 232 CG LEU 33 95, .610 27, .204 31. .662 1. .00 29, .43 ISG 233
ATOM 233 CD2 LEU 33 96, .476 28, .474 31. .612 1. ,00 29. .43 ISG 234
ATOM 234 CDl LEU 33 96 .425 25. .935 31. .952 1. .00 29. .43 ISG 235
ATOM 235 C LEU 33 92 .756 26, .441 31. .637 1. .00 29. .43 ISG 236
ATOM 236 O LEU 33 92, .826 25, .893 32. .736 1. .00 29, .43 ISG 237
ATOM 237 N LEU 34 91, .903 27, .450 31. .390 1. .00 32, .13 ISG 238
ATOM 238 CA LEU 34 91, .062 27. .979 32. .423 1. .00 32. .13 ISG 239
ATOM 239 CB LEU 34 90, .215 29. .177 31. .952 1. .00 32. .13 ISG 240
ATOM 240 CG LEU 34 91, .032 30. .401 31. .500 1. .00 32. .13 ISG 241
ATOM 241 CD2 LEU 34 92, .111 30. .767 32. .530 1. .00 32. .13 ISG 242
ATOM 242 CDl LEU 34 90, .110 31. .581 31. .147 1. .00 32, .13 ISG 243
ATOM 243 C LEU 34 90. .089 26. .931 32. .865 1. .00 32. .13 ISG 244
ATOM 244 O LEU 34 89. .851 26. .760 34. , 059 1. ,00 32. .13 ISG 245
ATOM 245 N GLN 35 89. .508 26. .196 31. .899 1. ,00 37. .61 ISG 246
ATOM 246 CA GLN 35 88, .470 25. .242 32. ,174 1. ,00 37. .61 ISG 247 ATOM 247 CB GLN 35 87 . 961 24 . 582 30 . 880 1 . 00 37 . 61 ISG 248
ATOM 248 CG GLN 35 87. .074 23. .358 31. .110 1. .00 37. .61 ISG 249
ATOM 249 CD GLN 35 85. .828 23. .777 31. .865 1. .00 37. .61 ISG 250
ATOM 250 OEl GLN 35 85. .901 24. .518 32. .843 1. .00 37. ,61 ISG 251
ATOM 251 NE2 GLN 35 84. .651 23. ,280 31. .402 1. .00 37. .61 ISG 252
ATOM 252 C GLN 35 88. .954 24. ,147 33. .069 1. .00 37. .61 ISG 253
ATOM 253 O GLN 35 88. .330 23. .856 34, .089 1. .00 37. .61 ISG 254
ATOM 254 N LYS 36 90, .106 23. .537 32, .747 1. .00 41. .26 ISG 255
ATOM 255 CA LYS 36 90, .546 22. .416 33, .527 1. .00 41. .26 ISG 256
ATOM 256 CB LYS 36 91. .823 21. .724 33. .029 1. .00 41. .26 ISG 257
ATOM 257 CG LYS 36 92. .178 20. .529 33. .923 1. .00 41. .26 ISG 258
ATOM 258 CD LYS 36 93, .277 19. .619 33. .373 1. .00 41, .26 ISG 259
ATOM 259 CE LYS 36 93, .667 18. .480 34. .320 1. .00 41, .26 ISG 260
ATOM 260 NZ LYS 36 94, .456 19. .008 35. .455 1. .00 41. .26 ISG 261
ATOM 261 C LYS 36 90. .840 22. .849 34. .924 1. .00 41. .26 ISG 262
ATOM 262 O LYS 36 90, .660 22. .079 35. .866 1. .00 41. .26 ISG 263
ATOM 263 N SER 37 91, .310 24, .098 35. .086 1. .00 42, .52 ISG 264
ATOM 264 CA SER 37 91, .732 24, .621 36. .354 1. .00 42, .52 ISG 265
ATOM 265 CB SER 37 92, .328 26, .034 36, .224 1, .00 42, .52 ISG 266
ATOM 266 OG SER 37 92, .733 26. .513 37, .497 1. .00 42, .52 ISG 267
ATOM 267 C SER 37 90, .557 24. .674 37, .287 1. .00 42 , .52 ISG 268
ATOM 268 O SER 37 90 .723 24, .832 38 .496 1. .00 42 .52 ISG 269
ATOM 269 N PHE 38 89 .336 24, .496 36 .747 1. .00 43 .41 ISG 270
ATOM 270 CA PHE 38 88 .128 24, .556 37 .523 1. .00 43, .41 ISG 271
ATOM 271 CB PHE 38 88 .161 23, .661 38, .773 1. .00 43, .41 ISG 272
ATOM 272 CG PHE 38 88, .353 22. .259 38, .311 1. .00 43 , .41 ISG 273
ATOM 273 CDl PHE 38 87 .346 21, .600 37 .645 1. .00 43 .41 ISG 274
ATOM 274 CD2 PHE 38 89 .532 21, .595 38 .562 1. .00 43 .41 ISG 275
ATOM 275 CE1 PHE 38 87 .521 20. .305 37, .220 1. .00 43 .41 ISG 276
ATOM 276 CE2 PHE 38 89 .711 20, .298 38, .141 1. .00 43, .41 ISG 277
ATOM 277 CZ PHE 38 88, .704 19, .651 37, .466 1. .00 43, .41 ISG 278
ATOM 278 C PHE 38 87 .932 25 .963 37 .983 1 .00 43 .41 ISG 279
ATOM 279 O PHE 38 87 .215 26, .220 38 .950 1, .00 43 .41 ISG 280
ATOM 280 N HIS 39 88 .587 26, .905 37 .280 1, .00 41 .95 ISG 281
ATOM 281 CA HIS 39 88 .482 28, .315 37, .516 1, .00 41 .95 ISG 282
ATOM 282 NDl HIS 39 89 .783 31, .414 37, .748 1, .00 41, .95 ISG 283
ATOM 283 CG HIS 39 89 .223 30 .624 36 .769 1 .00 41 .95 ISG 284
ATOM 284 CB HIS 39 89 .447 29 .142 36 .644 1, .00 41 .95 ISG 285
ATOM 285 NE2 HIS 39 88 .526 32. .755 36 .494 1, .00 41 .95 ISG 286
ATOM 286 CD2 HIS 39 88 .459 31, .459 36 .011 1, .00 41, .95 ISG 287
ATOM 287 CE1 HIS 39 89 .333 32, .677 37, .537 1, .00 41, .95 ISG 288
ATOM 288 C HIS 39 87 .118 28 .774 37 .144 1 .00 41 .95 ISG 289
ATOM 289 O HIS 39 86 .533 29 .611 37 .830 1, .00 41 .95 ISG 290
ATOM 290 N VAL 40 86 .563 28 .231 36 .046 1, .00 41, .47 ISG 291
ATOM 291 CA VAL 40 85 .335 28, .797 35 .590 1, .00 41, .47 ISG 292
ATOM 292 CB VAL 40 84 .991 28, .439 34, .186 1. .00 41, .47 ISG 293
ATOM 293 CGI VAL 40 83 .655 29 .126 33 .877 1, .00 41 .47 ISG 294
ATOM 294 CG2 VAL 40 86 .148 28 .826 33 .253 1, .00 41, .47 ISG 295
ATOM 295 C VAL 40 84 .199 28, .304 36 .419 1. .00 41, .47 ISG 296
ATOM 296 O VAL 40 83 .484 27, .374 36 .042 1, .00 41. .47 ISG 297
ATOM 297 N ASN 41 84 .011 28, .947 37, .580 1. .00 43. .11 ISG 298
ATOM 298 CA ASN 41 82 .893 28 .731 38 .444 1. .00 43. .11 ISG 299
ATOM 299 CB ASN 41 83 .055 27 .574 39 .447 1, .00 43, .11 ISG 300
ATOM 300 CG ASN 41 81 .780 27, .497 40 .284 1. .00 43, .11 ISG 301
ATOM 301 ODl ASN 41 80 .699 27, .187 39 .787 1. .00 43, .11 ISG 302
ATOM 302 ND2 ASN 41 81 .912 27, .791 41, .607 1. .00 43. .11 ISG 303
ATOM 303 C ASN 41 82 .823 29 .982 39 .241 1. .00 43. .11 ISG 304 ATOM 304 O ASN 41 83..823 30..399 39..821 1..00 43..11 ISG 305
ATOM 305 N ILE 42 81. .653 30. .639 39. .294 1. .00 44. .18 ISG 306
ATOM 306 CA ILE 42 81, .666 31. .841 40. .067 1. .00 44, .18 ISG 307
ATOM 307 CB ILE 42 81, .489 33. .103 39, .271 1, .00 44, .18 ISG 308
ATOM 308 CG2 ILE 42 82, .641 33. .170 38, .253 1. .00 44. .18 ISG 309
ATOM 309 CGI ILE 42 80 .096 33. .169 38 .632 1 .00 44 .18 ISG 310
ATOM 310 CDl ILE 42 79 .746 34. .541 38 .056 1 .00 44 .18 ISG 311
ATOM 311 C ILE 42 80 .566 31. .765 41 .068 1 .00 44 .18 ISG 312
ATOM 312 O ILE 42 79 .501 31. .211 40 .801 1 .00 44 .18 ISG 313
ATOM 313 N GLN 43 80 .846 32, .299 42 .274 1 .00 45 .02 ISG 314
ATOM 314 CA GLN 43 79 .914 32, .351 43 .363 1. .00 45. .02 ISG 315
ATOM 315 CB GLN 43 80, .289 31. .441 44 .544 1, .00 45, .02 ISG 316
ATOM 316 CG GLN 43 80 .266 29. .950 44 .213 1, .00 45, .02 ISG 317
ATOM 317 CD GLN 43 80, .689 29. .183 45, .459 1, .00 45, .02 ISG 318
ATOM 318 OEl GLN 43 80, .553 29. .659 46. .586 1, .00 45, .02 ISG 319
ATOM 319 NE2 GLN 43 81, .224 27. .951 45. .247 1, .00 45, .02 ISG 320
ATOM 320 C GLN 43 79, .987 33. .754 43. .882 1, .00 45, .02 ISG 321
ATOM 321 O GLN 43 80 .895 34. .501 43 .532 1 .00 45 .02 ISG 322
ATOM 322 N ASP 44 79 .021 34, .157 44 .727 1 .00 46 .00 ISG 323
ATOM 323 CA ASP 44 78 .971 35, .502 45 .228 1 .00 46 .00 ISG 324
ATOM 324 CB ASP 44 77 .771 35, .673 46 .168 1 .00 46 .00 ISG 325
ATOM 325 CG ASP 44 77, .872 37, .025 46 .842 1. .00 46 .00 ISG 326
ATOM 326 ODl ASP 44 77, .976 38. .059 46 .130 1 .00 46, .00 ISG 327
ATOM 327 OD2 ASP 44 77, .870 37. .024 48 .101 1, .00 46, .00 ISG 328
ATOM 328 C ASP 44 80, .203 35. .865 46. .013 1, .00 46, .00 ISG 329
ATOM 329 O ASP 44 80, .930 36. .784 45, .641 1, .00 46, .00 ISG 330
ATOM 330 N THR 45 80, .480 35. .139 47, .116 1, .00 43, .27 ISG 331
ATOM 331 CA THR 45 81, .574 35. .494 47, .980 1, .00 43, .27 ISG 332
ATOM 332 CB THR 45 81 .526 34. .799 49 .319 1 .00 43 .27 ISG 333
ATOM 333 OGl THR 45 82 .449 35. .402 50 .213 1 .00 43 .27 ISG 334
ATOM 334 CG2 THR 45 81 .863 33, .307 49 .155 1 .00 43 .27 ISG 335
ATOM 335 C THR 45 82, .897 35, .198 47 .349 1, .00 43 .27 ISG 336
ATOM 336 O THR 45 83. .828 35, .997 47 .428 1, .00 43, .27 ISG 337
ATOM 337 N MET 46 82. .998 34, .037 46, .681 1, .00 39, .50 ISG 338
ATOM 338 CA MET 46 84, .254 33. .554 46. .198 1, .00 39, .50 ISG 339
ATOM 339 CB MET 46 84, .154 32. .122 45. .637 1, .00 39, .50 ISG 340
ATOM 340 CG MET 46 83. .483 31. .158 46, .628 1, .00 39, .50 ISG 341
ATOM 341 SD MET 46 83. .847 29. .391 46. .395 1. .00 39, .50 ISG 342
ATOM 342 CE MET 46 85. .352 29. .413 47. .414 1, .00 39, .50 ISG 343
ATOM 343 C MET 46 84. .783 34. .478 45. .149 1, .00 39, .50 ISG 344
ATOM 344 o MET 46 85, .987 34. .714 45, .067 1, .00 39, .50 ISG 345
ATOM 345 N ILE 47 83, .890 35. .043 44 , .321 1, .00 36, .19 ISG 346
ATOM 346 CA ILE 47 84. .342 35. .905 43, .271 1, .00 36, .19 ISG 347
ATOM 347 CB ILE 47 83. .245 36. .483 42, .425 1, .00 36. .19 ISG 348
ATOM 348 CG2 ILE 47 82. .620 35. .355 41, .591 1. .00 36. .19 ISG 349
ATOM 349 CGI ILE 47 82. .276 37. .309 43. .296 1. .00 36. .19 ISG 350
ATOM 350 CDl ILE 47 81. .339 38. .216 42 , .498 1. .00 36. .19 ISG 351
ATOM 351 C ILE 47 85. .067 37. .076 43. .836 1. .00 36. .19 ISG 352
ATOM 352 O ILE 47 84. .646 37. .678 44. .823 1. .00 36. .19 ISG 353
ATOM 353 N GLY 48 86. .218 37. .399 43. .215 1. .00 32. .63 ISG 354
ATOM 354 CA GLY 48 86. ,934 38. ,594 43. .541 1. .00 32. .63 ISG 355
ATOM 355 C GLY 48 86. .963 39. .348 42. .251 1. .00 32. .63 ISG 356
ATOM 356 O GLY 48 87. .783 39. .071 41. .378 1. .00 32. .63 ISG 357
ATOM 357 N GLU 49 86. .058 40. .334 42. .103 1. .00 34. ,30 ISG 358
ATOM 358 CA GLU 49 85. .962 41. .034 40. .857 1. .00 34. ,30 ISG 359
ATOM 359 CB GLU 49 84. .957 40. .374 39. .898 1. .00 34. .30 ISG 360
ATOM 360 CG GLU 49 85. .342 38. .945 39. .500 1. .00 34. .30 ISG 361 ATOM 361 CD GLU 49 84..119 38.,292 38..867 1.,00 34..30 ISG 362
ATOM 362 OEl GLU 49 83. ,048 38. ,954 38. .859 1. ,00 34. .30 ISG 363
ATOM 363 OE2 GLU 49 84. .233 37. ,131 38, .390 1. ,00 34, .30 ISG 364
ATOM 364 C GLU 49 85. .454 42. .405 41, .161 1. .00 34. .30 ISG 365
ATOM 365 O GLU 49 85. .061 42. .698 42, .290 1. .00 34. .30 ISG 366
ATOM 366 N LEU 50 85. .480 43. .307 40, .163 1. .00 40. .40 ISG 367
ATOM 367 CA LEU 50 84. .980 44. .624 40. .420 1. .00 40. .40 ISG 368
ATOM 368 CB LEU 50 85. .221 45. .615 39. .263 1. .00 40. .40 ISG 369
ATOM 369 CG LEU 50 86. .710 45. .936 39, .036 1. .00 40. .40 ISG 370
ATOM 370 CD2 LEU 50 87. .382 46, .369 40 .348 1. .00 40. .40 ISG 371
ATOM 371 CDl LEU 50 86. .903 46. .966 37, .912 1. .00 40. .40 ISG 372
ATOM 372 C LEU 50 83. .511 44. .527 40 .692 1. .00 40 .40 ISG 373
ATOM 373 O LEU 50 82. .997 45. .172 41, .604 1. .00 40, .40 ISG 374
ATOM 374 N PRO 51 82. .794 43. .745 39, .938 1. .00 48, .48 ISG 375
ATOM 375 CA PRO 51 81. .393 43. .683 40 .238 1. .00 48 .48 ISG 376
ATOM 376 CD PRO 51 83. .038 43. .668 38, .505 1. .00 48, .48 ISG 377
ATOM 377 CB PRO 51 80. .699 43, .216 38 .960 1. .00 48 .48 ISG 378
ATOM 378 CG PRO 51 81. .651 43 , .676 37. .844 1, .00 48, .48 ISG 379
ATOM 379 C PRO 51 81, .095 42, .835 41, .433 1, .00 48 .48 ISG 380
ATOM 380 O PRO 51 81, .744 41. .807 41 .617 1, .00 48 .48 ISG 381
ATOM 381 N PRO 52 80. .167 43. .264 42, .244 1. .00 58, .14 ISG 382
ATOM 382 CA PRO 52 79, .708 42. .463 43 .348 1, .00 58 .14 ISG 383
ATOM 383 CD PRO 52 79, .989 44. .685 42 .485 1, .00 58 .14 ISG 384
ATOM 384 CB PRO 52 79, .205 43 .449 44 .405 1. .00 58 .14 ISG 385
ATOM 385 CG PRO 52 78. .965 44. .755 43 .626 1, .00 58 .14 ISG 386
ATOM 386 C PRO 52 78. .609 41. .633 42, .786 1. .00 58, .14 ISG 387
ATOM 387 O PRO 52 78. .066 42. .023 41 .758 1. .00 58 .14 ISG 388
ATOM 388 N GLN 53 78. .245 40, .484 43 .370 1, .00 64 .41 ISG 389
ATOM 389 CA GLN 53 77. .068 39 .953 42 .763 1. .00 64 .41 ISG 390
ATOM 390 CB GLN 53 77. .154 38, .491 42 .302 1. .00 64 .41 ISG 391
ATOM 391 CG GLN 53 77. .406 37 .472 43 .401 1, .00 64 .41 ISG 392
ATOM 392 CD GLN 53 77. .651 36. .161 42 .678 1, .00 64 .41 ISG 393
ATOM 393 OEl GLN 53 76. .724 35. .391 42 .430 1, .00 64, .41 ISG 394
ATOM 394 NE2 GLN 53 78, .936 35. .911 42 .309 1, .00 64 .41 ISG 395
ATOM 395 C GLN 53 75, .978 40. .174 43 .738 1, .00 64 .41 ISG 396
ATOM 396 O GLN 53 75, .684 39 .330 44 .580 1 .00 64 .41 ISG 397
ATOM 397 N THR 54 75. .389 41. .379 43 .641 1, .00 65 .49 ISG 398
ATOM 398 CA THR 54 74. .306 41. .845 44, .446 1. .00 65. .49 ISG 399
ATOM 399 CB THR 54 74, .722 42. .921 45 .403 1. .00 65 .49 ISG 400
ATOM 400 OGl THR 54 75. .276 44. .015 44 .687 1. .00 65. .49 ISG 401
ATOM 401 CG2 THR 54 75. .758 42. .344 46 .385 1, .00 65 .49 ISG 402
ATOM 402 C THR 54 73. .360 42, .447 43 .465 1. .00 65. .49 ISG 403
ATOM 403 O THR 54 73, .760 42. .843 42 .373 1. .00 65 .49 ISG 404
ATOM 404 N THR 55 72. .075 42, .548 43 .827 1. .00 63 .98 ISG 405
ATOM 405 CA THR 55 71. .132 43, .039 42, .874 1. .00 63. .98 ISG 406
ATOM 406 CB THR 55 69. .719 42, .947 43 .345 1. .00 63 .98 ISG 407
ATOM 407 OGl THR 55 68. .858 43 , .231 42, .261 1. .00 63. .98 ISG 408
ATOM 408 CG2 THR 55 69. .483 43. .937 44 .491 1. .00 63 .98 ISG 409
ATOM 409 C THR 55 71. .484 44, .456 42, .556 1. .00 63 .98 ISG 410
ATOM 410 O THR 55 71. .227 44, .947 41 .458 1. .00 63 .98 ISG 411
ATOM 411 N LYS 56 72. .096 45, .141 43, .534 1. .00 58. .58 ISG 412
ATOM 412 CA LYS 56 72. .460 46. .523 43, .451 1. .00 58. .58 ISG 413
ATOM 413 CB LYS 56 73. .234 46, .903 44 .729 1, .00 58. .58 ISG 414
ATOM 414 CG LYS 56 73. .540 48, .383 44, .933 1. .00 58, .58 ISG 415
ATOM 415 CD LYS 56 73 , .994 48, .700 46 .363 1. .00 58, .58 ISG 416
ATOM 416 CE LYS 56 75. ,338 48. .072 46, .750 1. .00 58, .58 ISG 417
ATOM 417 NZ LYS 56 75. .186 46. .615 46, .965 1. .00 58. .58 ISG 418 ATOM 418 C LYS 56 73..358 46..753 42..265 1..00 58..58 ISG 419
ATOM 419 O LYS 56 73. .055 47. .582 41. .407 1. .00 58. ,58 ISG 420
ATOM 420 N THR 57 74. ,475 46. .007 42. .158 1. .00 53. ,54 ISG 421
ATOM 421 CA THR 57 75. .363 46, .224 41. .051 1, .00 53. .54 ISG 422
ATOM 422 CB THR 57 76. .666 45, .490 41. .153 1. .00 53. .54 ISG 423
ATOM 423 OGl THR 57 77. .580 45, .970 40. .177 1. .00 53. .54 ISG 424
ATOM 424 CG2 THR 57 76. .398 44, .001 40, .925 1. .00 53. .54 ISG 425
ATOM 425 C THR 57 74. .675 45, .768 39, .810 1. .00 53. .54 ISG 426
ATOM 426 0 THR 57 74. .835 46. .346 38. .737 1. .00 53. .54 ISG 427
ATOM 427 N LEU 58 73. .866 44. .707 39. .945 1. .00 52. .21 ISG 428
ATOM 428 CA LEU 58 73. .178 44, .130 38, .836 1. .00 52. .21 ISG 429
ATOM 429 CB LEU 58 72. .367 42, .878 39. .185 1, .00 52. .21 ISG 430
ATOM 430 CG LEU 58 73. .242 41. .743 39. .742 1. .00 52. .21 ISG 431
ATOM 431 CD2 LEU 58 74. .606 41. .678 39, .042 1, .00 52. .21 ISG 432
ATOM 432 CDl LEU 58 72. .490 40, .408 39, .709 1. .00 52. .21 ISG 433
ATOM 433 C LEU 58 72. .244 45, .160 38, .316 1. .00 52. .21 ISG 434
ATOM 434 O LEU 58 71. .842 45 .116 37, .156 1, .00 52. .21 ISG 435
ATOM 435 N ALA 59 71. .868 46, .124 39, .169 1, .00 54, .64 ISG 436
ATOM 436 CA ALA 59 70. .896 47, .097 38, .769 1, .00 54. .64 ISG 437
ATOM 437 CB ALA 59 70. .667 48 .178 39 .837 1 .00 54. .64 ISG 438
ATOM 438 C ALA 59 71. .367 47 .789 37, .529 1 .00 54. .64 ISG 439
ATOM 439 O ALA 59 70, .578 48, .055 36, .626 1, .00 54. .64 ISG 440
ATOM 440 N ARG 60 72, .666 48 .105 37 .424 1 .00 64. .49 ISG 441
ATOM 441 CA ARG 60 73, .072 48, .771 36 .223 1 .00 64. .49 ISG 442
ATOM 442 CB ARG 60 74, .564 49, .153 36, .247 1, .00 64. .49 ISG 443
ATOM 443 CG ARG 60 75, .081 49, .757 34. .940 1, .00 64. .49 ISG 444
ATOM 444 CD ARG 60 76, .393 50 .536 35 .090 1 .00 64. .49 ISG 445
ATOM 445 NE ARG 60 77, .279 49, .777 36, .016 1 .00 64, .49 ISG 446
ATOM 446 CZ ARG 60 78, .636 49, .905 35. .927 1. .00 64, .49 ISG 447
ATOM 447 NHl ARG 60 79, .184 50 .743 34 .999 1 .00 64, .49 ISG 448
ATOM 448 NH2 ARG 60 79, .442 49, .186 36. .761 1, .00 64, .49 ISG 449
ATOM 449 C ARG 60 72, .810 47, .886 35. .030 1. .00 64, .49 ISG 450
ATOM 450 O ARG 60 72 .325 48 .355 33 .999 1 .00 64 .49 ISG 451
ATOM 451 N PHE 61 73, .177 46 .590 35 .114 1 .00 77, .73 ISG 452
ATOM 452 CA PHE 61 73, .016 45, .672 34. .015 1, .00 77, .73 ISG 453
ATOM 453 CB PHE 61 73 .789 44 .376 34 .268 1 .00 77 .73 ISG 454
ATOM 454 CG PHE 61 75, .168 44 .829 34 .570 1 .00 77, .73 ISG 455
ATOM 455 CDl PHE 61 76, .034 45 .143 33, .553 1, .00 77, .73 ISG 456
ATOM 456 CD2 PHE 61 75 .583 44, .951 35, .876 1, .00 77, .73 ISG 457
ATOM 457 CE1 PHE 61 77, .306 45 .568 33 .842 1 .00 77, .73 ISG 458
ATOM 458 CE2 PHE 61 76, .856 45 .377 36, .169 1, .00 77, .73 ISG 459
ATOM 459 CZ PHE 61 77, .719 45, .686 35, .148 1, .00 77, .73 ISG 460
ATOM 460 C PHE 61 71, .595 45 .266 33 .767 1 .00 77, .73 ISG 461
ATOM 461 0 PHE 61 71. .063 45 .506 32, .684 1, .00 77, .73 ISG 462
ATOM 462 N ILE 62 70. .929 44, .632 34, .762 1, .00 88. .19 ISG 463
ATOM 463 CA ILE 62 69. .594 44 .223 34 .449 1 .00 88, .19 ISG 464
ATOM 464 CB ILE 62 69. .424 42 .775 34 .047 1, .00 88. .19 ISG 465
ATOM 465 CG2 ILE 62 70. .282 42, .538 32, .795 1, .00 88. .19 ISG 466
ATOM 466 CGI ILE 62 69. .747 41 .799 35 .188 1 .00 88. .19 ISG 467
ATOM 467 CDl ILE 62 71, .196 41 .870 35 .654 1, .00 88. .19 ISG 468
ATOM 468 C ILE 62 68, .638 44, .480 35, .557 1, .00 88. .19 ISG 469
ATOM 469 0 ILE 62 68, .614 43 .844 36 .608 1 .00 88. .19 ISG 470
ATOM 470 N PRO 63 67, .807 45 .419 35 .290 1, .00 92. .23 ISG 471
ATOM 471 CA PRO 63 66. .664 45, .602 36. .112 1, .00 92. .23 ISG 472
ATOM 472 CD PRO 63 68. .192 46, ,616 34. .567 1. .00 92. .23 ISG 473
ATOM 473 CB PRO 63 66, .182 47, .029 35 .838 1, .00 92. .23 ISG 474
ATOM 474 CG PRO 63 66, .905 47. .448 34. .542 1, .00 92. .23 ISG 475 ATOM 475 C PRO 63 65..862 44..504 35.,480 1..00 92..23 ISG 476
ATOM 476 O PRO 63 66. .202 44. .101 34. ,369 1. .00 92. .23 ISG 477
ATOM 477 N GLU 64 64. .790 44. .013 36. ,106 1. 00 87. .46 ISG 478
ATOM 478 CA GLU 64 64. .319 44. .592 37. .303 1. ,00 87. ,46 ISG 479
ATOM 479 CB GLU 64 62. .808 44. .382 37. .374 1. ,00 87. ,46 ISG 480
ATOM 480 CG GLU 64 62. .079 44. .689 36. .058 1. .00 87. ,46 ISG 481
ATOM 481 CD GLU 64 62. .270 46. .137 35. .621 1. .00 87. .46 ISG 482
ATOM 482 OEl GLU 64 63. .375 46. .703 35. .831 1. .00 87. ,46 ISG 483
ATOM 483 OE2 GLU 64 61. .297 46. .692 35. .046 1. .00 87. .46 ISG 484
ATOM 484 C GLU 64 64. .912 43. .852 38. .465 1. .00 87. ,46 ISG 485
ATOM 485 O GLU 64 64. .223 43. .637 39. .455 1. .00 87. .46 ISG 486
ATOM 486 N VAL 65 66. .205 43. .462 38. .413 1. .00 74. .13 ISG 487
ATOM 487 CA VAL 65 66. .738 42. .797 39. .564 1. ,00 74. .13 ISG 488
ATOM 488 CB VAL 65 68, .164 42, .313 39. .404 1. .00 74. .13 ISG 489
ATOM 489 CGI VAL 65 68. .198 41. .333 38. .221 1. .00 74. .13 ISG 490
ATOM 490 CG2 VAL 65 69, .150 43. .486 39. .263 1. .00 74. .13 ISG 491
ATOM 491 C VAL 65 66, .675 43. .804 40, .663 1. .00 74, .13 ISG 492
ATOM 492 O VAL 65 66, .279 43, .499 41. .787 1. .00 74 , .13 ISG 493
ATOM 493 N ALA 66 67, .089 45, .045 40. .354 1. .00 61, .75 ISG 494
ATOM 494 CA ALA 66 67. .087 46 , .085 41, ,330 1. .00 61, .75 ISG 495
ATOM 495 CB ALA 66 67, .787 47, .362 40. .834 1. .00 61, .75 ISG 496
ATOM 496 C ALA 66 65, .685 46 .453 41. .695 1. .00 61 .75 ISG 497
ATOM 497 O ALA 66 65, .368 46, .576 42. .875 1. .00 61, .75 ISG 498
ATOM 498 N VAL 67 64, .790 46 .653 40. .705 1. .00 54, .47 ISG 499
ATOM 499 CA VAL 67 63, .494 47, .103 41, .134 1. .00 54 .47 ISG 500
ATOM 500 CB VAL 67 62, .635 47, .747 40, .079 1. .00 54, .47 ISG 501
ATOM 501 CGI VAL 67 63, .375 48 .974 39 .521 1. .00 54 .47 ISG 502
ATOM 502 CG2 VAL 67 62, .199 46, .709 39, .046 1. .00 54, .47 ISG 503
ATOM 503 C VAL 67 62, .706 46, .013 41, .803 1, .00 54 .47 ISG 504
ATOM 504 O VAL 67 62, .089 46 .248 42 .841 1. .00 54 .47 ISG 505
ATOM 505 N ALA 68 62, .680 44, .795 41, .224 1. .00 51, .06 ISG 506
ATOM 506 CA ALA 68 61 .902 43 .722 41, .788 1. .00 51 .06 ISG 507
ATOM 507 CB ALA 68 61, .895 42, .468 40, .900 1. .00 51, .06 ISG 508
ATOM 508 C ALA 68 62, .460 43 .324 43, .118 1. .00 51 .06 ISG 509
ATOM 509 O ALA 68 61, .718 43 .166 44, .088 1. .00 51 .06 ISG 510
ATOM 510 N TYR 69 63, .795 43, .151 43, .193 1. .00 54, .28 ISG 511
ATOM 511 CA TYR 69 64, .414 42 .782 44 .432 1, .00 54 .28 ISG 512
ATOM 512 CB TYR 69 65, .431 41. .639 44 , .288 1. .00 54, .28 ISG 513
ATOM 513 CG TYR 69 64, .725 40 .476 43, .688 1, .00 54 .28 ISG 514
ATOM 514 CDl TYR 69 64 .619 40 .364 42 .322 1. .00 54 .28 ISG 515
ATOM 515 CD2 TYR 69 64, .170 39 .501 44, .481 1. .00 54. .28 ISG 516
ATOM 516 CE1 TYR 69 63 .970 39 .294 41, .755 1. .00 54. .28 ISG 517
ATOM 517 CE2 TYR 69 63, .519 38. .429 43, .917 1. .00 54. .28 ISG 518
ATOM 518 CZ TYR 69 63, .417 38 .323 42, .551 1. .00 54, .28 ISG 519
ATOM 519 OH TYR 69 62 .750 37 .225 41 .965 1. .00 54. .28 ISG 520
ATOM 520 C TYR 69 65, .218 43. .967 44, .849 1. .00 54, .28 ISG 521
ATOM 521 O TYR 69 66, .380 44 .100 44, .469 1. .00 54, .28 ISG 522
ATOM 522 N PRO 70 64, .635 44, .834 45, .621 1. .00 59, .28 ISG 523
ATOM 523 CA PRO 70 65. .384 45, .991 46, .017 1. .00 59, .28 ISG 524
ATOM 524 CD PRO 70 63 .230 45 .152 45, .417 1. .00 59, .28 ISG 525
ATOM 525 CB PRO 70 64, .361 47, .046 46, .430 1. .00 59. .28 ISG 526
ATOM 526 CG PRO 70 63, .115 46, .673 45. .611 1. .00 59. .28 ISG 527
ATOM 527 C PRO 70 66, .406 45, .728 47. .067 1. .00 59. .28 ISG 528
ATOM 528 0 PRO 70 66, .105 45, .026 48, .033 1. .00 59. .28 ISG 529
ATOM 529 N LYS 71 67. .606 46, .317 46, .879 1. .00 60, .67 ISG 530
ATOM 530 CA LYS 71 68. .672 46, .292 47. .833 1. .00 60. .67 ISG 531
ATOM 531 CB LYS 71 68, .449 47, .253 49. .017 1. .00 60. .67 ISG 532 ATOM 532 CG LYS 71 68..464 48..739 48..646 1..00 60..67 ISG 533
ATOM 533 CD LYS 71 67. .250 49. .195 47. .832 1. .00 60. ,67 ISG 534
ATOM 534 CE LYS 71 65. .953 49. .302 48. .642 1. .00 60. ,67 ISG 535
ATOM 535 NZ LYS 71 64. .905 49. .970 47. .836 1. .00 60. .67 ISG 536
ATOM 536 C LYS 71 68. .809 44. .920 48. .388 1. .00 60. .67 ISG 537
ATOM 537 o LYS 71 68. .725 44, .738 49. .602 1. .00 60. .67 ISG 538
ATOM 538 N SER 72 69. .004 43. .906 47. .529 1. ,00 61. .34 ISG 539
ATOM 539 CA SER 72 69. .120 42. .609 48. .110 1. ,00 61. .34 ISG 540
ATOM 540 CB SER 72 68. .439 41. .464 47. .334 1. .00 61. .34 ISG 541
ATOM 541 OG SER 72 69. .212 41, .082 46. .207 1. .00 61. .34 ISG 542
ATOM 542 C SER 72 70. .567 42, .313 48, .198 1. .00 61. .34 ISG 543
ATOM 543 O SER 72 71. .380 42. .781 47. .398 1. .00 61. .34 ISG 544
ATOM 544 N LYS 73 70. .901 41. .487 49. .195 1. .00 60. .73 ISG 545
ATOM 545 CA LYS 73 72. .247 41. .158 49. .508 1. .00 60. .73 ISG 546
ATOM 546 CB LYS 73 72. .357 40. .229 50. .725 1. .00 60, .73 ISG 547
ATOM 547 CG LYS 73 71, .976 40. .942 52. .020 1. .00 60. .73 ISG 548
ATOM 548 CD LYS 73 71. .925 40. .017 53. .230 1. .00 60. .73 ISG 549
ATOM 549 CE LYS 73 71. .600 40, .750 54. .531 1. .00 60. .73 ISG 550
ATOM 550 NZ LYS 73 71. .744 39, .829 55, .680 1. .00 60, .73 ISG 551
ATOM 551 C LYS 73 72, .875 40, .517 48, .333 1. .00 60. .73 ISG 552
ATOM 552 O LYS 73 72, .296 40, .413 47, .252 1. .00 60. .73 ISG 553
ATOM 553 N PRO 74 74. .103 40. .147 48, .522 1. .00 55. .97 ISG 554
ATOM 554 CA PRO 74 74 , .796 39. .514 47, .461 1. .00 55. .97 ISG 555
ATOM 555 CD PRO 74 75, .018 40. .818 49, .426 1. .00 55, .97 ISG 556
ATOM 556 CB PRO 74 76. .226 39. .309 47, .964 1. .00 55, .97 ISG 557
ATOM 557 CG PRO 74 76. .233 39. .880 49, .401 1. .00 55, .97 ISG 558
ATOM 558 C PRO 74 74. .029 38. .309 47. .055 1. .00 55. .97 ISG 559
ATOM 559 O PRO 74 73. .826 37. .403 47. .861 1. .00 55, .97 ISG 560
ATOM 560 N LEU 75 73. .615 38. .309 45. .780 1, .00 53, .89 ISG 561
ATOM 561 CA LEU 75 72. .820 37. .294 45. .185 1, .00 53. .89 ISG 562
ATOM 562 CB LEU 75 72. .445 37. .635 43. .741 1. .00 53, .89 ISG 563
ATOM 563 CG LEU 75 71. .937 39. .078 43, .569 1 , .00 53, .89 ISG 564
ATOM 564 CD2 LEU 75 70, .997 39. .511 44. .700 1, .00 53, .89 ISG 565
ATOM 565 CDl LEU 75 71. .344 39. .285 42, .172 1, .00 53, .89 ISG 566
ATOM 566 C LEU 75 73. .708 36. .105 45, .108 1, .00 53, .89 ISG 567
ATOM 567 O LEU 75 74, .930 36. .243 45, .057 1, .00 53, .89 ISG 568
ATOM 568 N THR 76 73. .115 34. .899 45. .133 1. .00 52. .49 ISG 569
ATOM 569 CA THR 76 73 , .944 33. .741 45. .013 1. .00 52, .49 ISG 570
ATOM 570 CB THR 76 73 , .735 32, .702 46, .080 1. .00 52, .49 ISG 571
ATOM 571 OGl THR 76 74, .782 31, .744 46, .031 1, .00 52, .49 ISG 572
ATOM 572 CG2 THR 76 72, .379 32, .008 45, .862 1. .00 52, .49 ISG 573
ATOM 573 C THR 76 73. .635 33. .115 43, .697 1. .00 52. .49 ISG 574
ATOM 574 O THR 76 72. .480 33. .015 43, .288 1. .00 52. .49 ISG 575
ATOM 575 N THR 77 74, .687 32. .712 42. .969 1. .00 49. .87 ISG 576
ATOM 576 CA THR 77 74, .451 32, .085 41. .710 1. .00 49. .87 ISG 577
ATOM 577 CB THR 77 74, .687 33, .010 40. .550 1. .00 49. .87 ISG 578
ATOM 578 OGl THR 77 74. .216 32. .435 39. .344 1. .00 49. .87 ISG 579
ATOM 579 CG2 THR 77 76, .191 33. .295 40. .441 1. .00 49. .87 ISG 580
ATOM 580 C THR 77 75, .410 30. .952 41, .617 1. .00 49. .87 ISG 581
ATOM 581 O THR 77 76, .480 30. .981 42, .221 1, .00 49. .87 ISG 582
ATOM 582 N GLN 78 75, .030 29. .893 40, .885 1. .00 49. .39 ISG 583
ATOM 583 CA GLN 78 75. .940 28. .804 40. .734 1. .00 49. .39 ISG 584
ATOM 584 CB GLN 78 75. .361 27. .501 41. .308 1. .00 49. .39 ISG 585
ATOM 585 CG GLN 78 75. .094 27. .661 42, .807 1. .00 49. .39 ISG 586
ATOM 586 CD GLN 78 74. .381 26. .434 43, .350 1. .00 49. .39 ISG 587
ATOM 587 OEl GLN 78 74. .306 26. .261 44. .565 1. .00 49. .39 ISG 588
ATOM 588 NE2 GLN 78 73. .845 25. ,568 42. .449 1. ,00 49. .39 ISG 589 ATOM 589 C GLN 78 76..171 28..657 39..267 1..00 49..39 ISG 590
ATOM 590 O GLN 78 75. .303 28. .178 38. .540 1, .00 49. .39 ISG 591
ATOM 591 N ILE 79 77. .351 29, .094 38. .779 1. .00 48. .84 ISG 592
ATOM 592 CA ILE 79 77, .574 28 .974 37. .370 1. .00 48. .84 ISG 593
ATOM 593 CB ILE 79 77. .503 30, .290 36, .641 1. .00 48. .84 ISG 594
ATOM 594 CG2 ILE 79 78. .732 31, .108 37, .042 1. .00 48. .84 ISG 595
ATOM 595 CGI ILE 79 77. .362 30, .088 35, .124 1, .00 48. .84 ISG 596
ATOM 596 CDl ILE 79 76. .932 31, .344 34, .362 1, .00 48. .84 ISG 597
ATOM 597 C ILE 79 78, .912 28, .362 37 .151 1, .00 48, .84 ISG 598
ATOM 598 O ILE 79 79. .901 28, .735 37, .782 1, .00 48. .84 ISG 599
ATOM 599 N LYS 80 78, .949 27 .364 36 .253 1 .00 48. .92 ISG 600
ATOM 600 CA LYS 80 80. .167 26, .703 35, .903 1, .00 48, .92 ISG 601
ATOM 601 CB LYS 80 80, .282 25, .251 36 .405 1, .00 48, .92 ISG 602
ATOM 602 CG LYS 80 80, .429 25, .069 37 .916 1, .00 48. .92 ISG 603
ATOM 603 CD LYS 80 80. .418 23, .595 38, .337 1, .00 48. .92 ISG 604
ATOM 604 CE LYS 80 80. .921 23, .357 39 .763 1, .00 48. .92 ISG 605
ATOM 605 NZ LYS 80 81. .137 21, .910 39, .993 1, .00 48, .92 ISG 606
ATOM 606 C LYS 80 80. .152 26 .571 34 .421 1, .00 48, .92 ISG 607
ATOM 607 O LYS 80 79. .091 26. .600 33 .800 1, .00 48, .92 ISG 608
ATOM 608 N ILE 81 81, .339 26 .425 33 .803 1 .00 51 .17 ISG 609
ATOM 609 CA ILE 81 81, .300 26 .186 32 .393 1, .00 51, .17 ISG 610
ATOM 610 CB ILE 81 82. .389 26. .796 31. .551 1, .00 51, .17 ISG 611
ATOM 611 CG2 ILE 81 82. .174 28. .316 31 .475 1, .00 51, .17 ISG 612
ATOM 612 CGI ILE 81 83. .780 26. .327 31, .993 1, .00 51, .17 ISG 613
ATOM 613 CDl ILE 81 84. .844 26 .583 30 .928 1 .00 51, .17 ISG 614
ATOM 614 C ILE 81 81, .357 24. .711 32, .212 1, .00 51. .17 ISG 615
ATOM 615 O ILE 81 82, .174 24 .026 32 .827 1 .00 51 .17 ISG 616
ATOM 616 N LYS 82 80, .415 24. .197 31 .396 1, .00 52. .65 ISG 617
ATOM 617 CA LYS 82 80 .297 22 .797 31 .113 1 .00 52 .65 ISG 618
ATOM 618 CB LYS 82 79, .106 22 .471 30, .187 1, .00 52. .65 ISG 619
ATOM 619 CG LYS 82 78. .961 20. .976 29, .877 1, .00 52. .65 ISG 620
ATOM 620 CD LYS 82 77, .670 20. .606 29 .137 1 .00 52, .65 ISG 621
ATOM 621 CE LYS 82 77, .614 19, .141 28, .691 1, .00 52, .65 ISG 622
ATOM 622 NZ LYS 82 76, .390 18, .893 27 .894 1 .00 52, .65 ISG 623
ATOM 623 C LYS 82 81, .525 22, .320 30, .388 1, .00 52, .65 ISG 624
ATOM 624 O LYS 82 82, .119 21 .314 30 .773 1, .00 52 .65 ISG 625
ATOM 625 N LYS 83 81, .951 23, .049 29, .330 1, .00 52, .81 ISG 626
ATOM 626 CA LYS 83 83, .060 22 .624 28 .509 1, .00 52, .81 ISG 627
ATOM 627 CB LYS 83 82, .608 22, .129 27, .120 1, .00 52, .81 ISG 628
ATOM 628 CG LYS 83 83. .736 21, .669 26. .191 1. .00 52. .81 ISG 629
ATOM 629 CD LYS 83 84. .360 20, .320 26. .554 1. .00 52. .81 ISG 630
ATOM 630 CE LYS 83 83. .669 19, .145 25, .863 1. .00 52. .81 ISG 631
ATOM 631 NZ LYS 83 83. .695 19, .347 24, .397 1, .00 52. .81 ISG 632
ATOM 632 C LYS 83 83. .969 23, .795 28, .263 1. .00 52. .81 ISG 633
ATOM 633 O LYS 83 83, .624 24, .941 28, .542 1. .00 52. .81 ISG 634
ATOM 634 N PRO 84 85. .149 23, .526 27, .762 1. .00 50. .53 ISG 635
ATOM 635 CA PRO 84 86, .033 24, .614 27, .450 1, .00 50, .53 ISG 636
ATOM 636 CD PRO 84 85, .888 22. .353 28. .203 1. .00 50. .53 ISG 637
ATOM 637 CB PRO 84 87. .403 23. .986 27. .216 1. .00 50. ,53 ISG 638
ATOM 638 CG PRO 84 87. .374 22, .740 28. .123 1. .00 50. .53 ISG 639
ATOM 639 C PRO 84 85. .475 25. .402 26. .315 1. .00 50. .53 ISG 640
ATOM 640 O PRO 84 85. .012 24, .814 25. .339 1. .00 50. .53 ISG 641
ATOM 641 N PRO 85 85. .515 26, .696 26. .415 1. .00 46. ,35 ISG 642
ATOM 642 CA PRO 85 84. .945 27, .501 25, .377 1. .00 46. .35 ISG 643
ATOM 643 CD PRO 85 85. ,451 27. .355 27. .706 1. , 00 46. .35 ISG 644
ATOM 644 CB PRO 85 84. .705 28, .884 25. .984 1. .00 46. .35 ISG 645
ATOM 645 CG PRO 85 85. .431 28, .847 27. .343 1. .00 46. .35 ISG 646 ATOM 646 C PRO 85 85..780 27..506 24..143 1..00 46..35 ISG 647
ATOM 647 O PRO 85 87. .006 27. .518 24. .238 1. .00 46. .35 ISG 648
ATOM 648 N LYS 86 85. .133 27 .516 22. .966 1, .00 43. .30 ISG 649
ATOM 649 CA LYS 86 85. .881 27 .532 21. .750 1, .00 43. .30 ISG 650
ATOM 650 CB LYS 86 85 .416 26 .485 20. .722 1. .00 43. .30 ISG 651
ATOM 651 CG LYS 86 83. .918 26 .555 20. .426 1. .00 43. .30 ISG 652
ATOM 652 CD LYS 86 83. .507 25 .835 19. .142 1. .00 43. .30 ISG 653
ATOM 653 CE LYS 86 83. .929 26 .597 17, .885 1. .00 43. .30 ISG 654
ATOM 654 NZ LYS 86 83. .186 26 .093 16, .711 1, .00 43. .30 ISG 655
ATOM 655 C LYS 86 85, .744 28. .885 21. .137 1. .00 43. .30 ISG 656
ATOM 656 O LYS 86 84 , .731 29. .561 21. .311 1. .00 43, .30 ISG 657
ATOM 657 N VAL 87 86. .804 29 .327 20. .433 1. .00 42. .12 ISG 658
ATOM 658 CA VAL 87 86 .794 30 .589 19, .759 1. .00 42. .12 ISG 659
ATOM 659 CB VAL 87 87 .796 31 .560 20, .308 1. .00 42. .12 ISG 660
ATOM 660 CGI VAL 87 87 .413 31 .859 21, .767 1, .00 42. .12 ISG 661
ATOM 661 CG2 VAL 87 89. .210 30 .977 20. .130 1, .00 42. .12 ISG 662
ATOM 662 C VAL 87 87. .162 30 .310 18, .341 1. .00 42. .12 ISG 663
ATOM 663 O VAL 87 88, .083 29 .542 18, .064 1. .00 42, .12 ISG 664
ATOM 664 N THR 88 86, .442 30 .929 17, .389 1. .00 42, .41 ISG 665
ATOM 665 CA THR 88 86, .745 30 .644 16, .021 1. .00 42. .41 ISG 666
ATOM 666 CB THR 88 85, .559 30 .148 15, .253 1. .00 42. .41 ISG 667
ATOM 667 OGl THR 88 84 .565 31 .160 15 .199 1 .00 42 .41 ISG 668
ATOM 668 CG2 THR 88 85 .004 28 .896 15, .953 1. .00 42 .41 ISG 669
ATOM 669 C THR 88 87 .172 31 .913 15, .365 1. .00 42 .41 ISG 670
ATOM 670 O THR 88 86, .533 32 .952 15, .524 1. .00 42. .41 ISG 671
ATOM 671 N MET 89 88, .284 31 .862 14, .605 1, .00 43, .61 ISG 672
ATOM 672 CA MET 89 88, .691 33 .042 13, .902 1, .00 43, .61 ISG 673
ATOM 673 CB MET 89 90, .191 33 .371 13, .953 1. .00 43, .61 ISG 674
ATOM 674 CG MET 89 90, .501 34, .633 13. .142 1. .00 43, .61 ISG 675
ATOM 675 SD MET 89 92 , .178 35, .297 13. .334 1. .00 43, .61 ISG 676
ATOM 676 CE MET 89 91 .777 36 .085 14, .919 1. .00 43 .61 ISG 677
ATOM 677 C MET 89 88 .349 32 .849 12, .467 1. .00 43 .61 ISG 678
ATOM 678 O MET 89 88 .589 31 .790 11, .890 1. .00 43, .61 ISG 679
ATOM 679 N LYS 90 87, .762 33 .888 11, .852 1. .00 44, .29 ISG 680
ATOM 680 CA LYS 90 87, .358 33 .778 10, .486 1. .00 44, .29 ISG 681
ATOM 681 CB LYS 90 85, .880 33, .351 10, .404 1. .00 44, .29 ISG 682
ATOM 682 CG LYS 90 85, .391 32, .798 9, .066 1. .00 44 , .29 ISG 683
ATOM 683 CD LYS 90 85, .249 33, .826 7. .946 1. .00 44, .29 ISG 684
ATOM 684 CE LYS 90 84, .461 33 , .284 6. .752 1. .00 44, .29 ISG 685
ATOM 685 NZ LYS 90 84, .148 34 .376 5, .805 1, .00 44, .29 ISG 686
ATOM 686 C LYS 90 87, .523 35 .142 9, .910 1. .00 44. .29 ISG 687
ATOM 687 O LYS 90 87, .590 36 .121 10. .652 1. .00 44. .29 ISG 688
ATOM 688 N THR 91 87, .602 35, .258 8. .569 1. .00 42. .44 ISG 689
ATOM 689 CA THR 91 87, .753 36, .582 8. .052 1. .00 42. .44 ISG 690
ATOM 690 CB THR 91 88. .063 36, .666 6. .588 1. .00 42. .44 ISG 691
ATOM 691 OGl THR 91 87. .021 36, .070 5. .830 1. .00 42. .44 ISG 692
ATOM 692 CG2 THR 91 89. .404 35. .965 6. .320 1. .00 42. .44 ISG 693
ATOM 693 C THR 91 86. .438 37. .227 8. .272 1. ,00 42. .44 ISG 694
ATOM 694 O THR 91 85. .409 36. .795 7. .757 1. .00 42, .44 ISG 695
ATOM 695 N GLY 92 86. .458 38. .294 9. .076 1. .00 40. .22 ISG 696
ATOM 696 CA GLY 92 85. .244 38, .912 9. .478 1. .00 40. .22 ISG 697
ATOM 697 C GLY 92 85. .471 39, .152 10. .922 1. .00 40. .22 ISG 698
ATOM 698 O GLY 92 86. .065 40, .156 11. .311 1. .00 40. .22 ISG 699
ATOM 699 N LYS 93 84. .992 38. .222 11. .762 1. ,00 38. .17 ISG 700
ATOM 700 CA LYS 93 85. .223 38. .393 13. .159 1. ,00 38. .17 ISG 701
ATOM 701 CB LYS 93 84. .079 39. .119 13. ,891 1. ,00 38. .17 ISG 702
ATOM 702 CG LYS 93 83. .931 40. .601 13. ,526 1. ,00 38. .17 ISG 703 ATOM 703 CD LYS 93 85 . 121 41.482 13 . 925 1 . 00 38 . 17 ISG 704
ATOM 704 CE LYS 93 84. ,928 42. .955 13. ,549 1. ,00 38. ,17 ISG 705
ATOM 705 NZ LYS 93 86. .113 43. .756 13. .936 1. ,00 38. ,17 ISG 706
ATOM 706 C LYS 93 85. .373 37. .041 13. .774 1. ,00 38. .17 ISG 707
ATOM 707 O LYS 93 85. .343 36. .017 13. .092 1. .00 38. .17 ISG 708
ATOM 708 N SER 94 85. .580 37. .012 15. .102 1. ,00 36. .38 ISG 709
ATOM 709 CA SER 94 85. .691 35. .745 15. .749 1. .00 36. .38 ISG 710
ATOM 710 CB SER 94 86. .918 35. .579 16. .662 1. .00 36. .38 ISG 711
ATOM 711 OG SER 94 88. .099 35. .484 15. .877 1. .00 36. .38 ISG 712
ATOM 712 C SER 94 84. .470 35. .544 16. .574 1. .00 36. .38 ISG 713
ATOM 713 O SER 94 83. .847 36. .491 17. .055 1. .00 36. .38 ISG 714
ATOM 714 N LEU 95 84. .085 34. .266 16. .719 1. .00 37. .14 ISG 715
ATOM 715 CA LEU 95 82. .918 33. .928 17. .467 1. .00 37. .14 ISG 716
ATOM 716 CB LEU 95 81. .909 33. .096 16. .664 1. ,00 37. .14 ISG 717
ATOM 717 CG LEU 95 81. .325 33. .861 15. .465 1. .00 37. .14 ISG 718
ATOM 718 CD2 LEU 95 80. .751 35. .217 15. .902 1. .00 37. .14 ISG 719
ATOM 719 CDl LEU 95 80. .312 33. .002 14. .692 1. .00 37. .14 ISG 720
ATOM 720 C LEU 95 83. .346 33. .104 18. .633 1. .00 37. .14 ISG 721
ATOM 721 O LEU 95 84. .289 32. .319 18, .548 1. .00 37, .14 ISG 722
ATOM 722 N LEU 96 82. .652 33 .297 19. .770 1. .00 39 .98 ISG 723
ATOM 723 CA LEU 96 82, .912 32. .570 20, .976 1, .00 39, .98 ISG 724
ATOM 724 CB LEU 96 83, .110 33 .503 22 .190 1. .00 39 .98 ISG 725
ATOM 725 CG LEU 96 83. .099 32. .820 23, .575 1. .00 39, .98 ISG 726
ATOM 726 CD2 LEU 96 83. .987 31. .565 23, .591 1. .00 39 .98 ISG 727
ATOM 727 CDl LEU 96 81. .665 32, .537 24, .059 1, .00 39, .98 ISG 728
ATOM 728 C LEU 96 81. .735 31 .693 21 .244 1. .00 39 .98 ISG 729
ATOM 729 0 LEU 96 80, .591 32, .094 21, .037 1. .00 39, .98 ISG 730
ATOM 730 N HIS 97 81 .990 30 .446 21 .693 1. .00 42 .44 ISG 731
ATOM 731 CA HIS 97 80, .893 29, .583 22, .022 1. .00 42, .44 ISG 732
ATOM 732 NDl HIS 97 80, .719 27 .578 18, .772 1. .00 42 .44 ISG 733
ATOM 733 CG HIS 97 80, .447 28, .481 19, .775 1. .00 42, .44 ISG 734
ATOM 734 CB HIS 97 80 .841 28 .278 21, .207 1. .00 42 .44 ISG 735
ATOM 735 NE2 HIS 97 79, .643 29, .276 17, .824 1. .00 42, .44 ISG 736
ATOM 736 CD2 HIS 97 79 .787 29 .511 19, .181 1, .00 42 .44 ISG 737
ATOM 737 CE1 HIS 97 80, .217 28, .104 17, .627 1. .00 42, .44 ISG 738
ATOM 738 C HIS 97 81, .046 29 .171 23 .447 1. .00 42, .44 ISG 739
ATOM 739 0 HIS 97 81, .793 28 .245 23 .755 1. .00 42 .44 ISG 740
ATOM 740 N LEU 98 80, .335 29 .830 24, .377 1, .00 46, .01 ISG 741
ATOM 741 CA LEU 98 80 .507 29 .356 25 .714 1, .00 46 .01 ISG 742
ATOM 742 CB LEU 98 80, .688 30 .424 26, .808 1. .00 46, .01 ISG 743
ATOM 743 CG LEU 98 79 .395 31 .154 27 .210 1. .00 46 .01 ISG 744
ATOM 744 CD2 LEU 98 78, .773 31 .901 26, .020 1. .00 46, .01 ISG 745
ATOM 745 CDl LEU 98 79, .646 32 .080 28 .410 1, .00 46, .01 ISG 746
ATOM 746 C LEU 98 79, .293 28, .584 26, .087 1. .00 46, .01 ISG 747
ATOM 747 O LEU 98 78, .190 28 .865 25 .620 1. .00 46, .01 ISG 748
ATOM 748 N HIS 99 79, .504 27, .552 26, .925 1. .00 47, .66 ISG 749
ATOM 749 CA HIS 99 78 .438 26 .748 27 .436 1. .00 47, .66 ISG 750
ATOM 750 NDl HIS 99 78, .649 24, .943 24, .779 1. .00 47. .66 ISG 751
ATOM 751 CG HIS 99 79, .264 24 .807 26 .001 1. .00 47. .66 ISG 752
ATOM 752 CB HIS 99 78, .672 25, .238 27, .305 1. .00 47. .66 ISG 753
ATOM 753 NE2 HIS 99 80, .602 23 .945 24, .404 1. .00 47, .66 ISG 754
ATOM 754 CD2 HIS 99 80, .456 24, .198 25, .756 1. .00 47. .66 ISG 755
ATOM 755 CE1 HIS 99 79, .494 24 .411 23, .858 1. .00 47. .66 ISG 756
ATOM 756 C HIS 99 78 .539 26 .959 28 .904 1. .00 47. .66 ISG 757
ATOM 757 0 HIS 99 79, .617 26. .789 29. .472 1. .00 47. .66 ISG 758
ATOM 758 N SER 100 77, .444 27 .341 29. .575 1, .00 47. .83 ISG 759
ATOM 759 CA SER 100 77, .624 27. .522 30, .979 1. .00 47. .83 ISG 760 ATOM 760 CB SER 100 78..003 28.,966 31..343 1.00 47.,83 ISG 761
ATOM 761 OG SER 100 78. .299 29. .049 32. .727 1. .00 47. .83 ISG 762
ATOM 762 C SER 100 76, .335 27. .203 31. .646 1. 00 47. .83 ISG 763
ATOM 763 O SER 100 75. .272 27. .338 31. ,045 1. 00 47. ,83 ISG 764
ATOM 764 N THR 101 76. .402 26. .748 32. ,913 1. 00 49. .68 ISG 765
ATOM 765 CA THR 101 75. .192 26. .494 33. .632 1. .00 49. .68 ISG 766
ATOM 766 CB THR 101 75, .144 25. .161 34. .335 1. .00 49. .68 ISG 767
ATOM 767 OGl THR 101 73. .902 25, .014 35. .007 1. ,00 49. .68 ISG 768
ATOM 768 CG2 THR 101 76. .313 25. .033 35. .328 1. ,00 49. ,68 ISG 769
ATOM 769 C THR 101 75. .089 27. .588 34. .638 1. .00 49. .68 ISG 770
ATOM 770 O THR 101 75. .943 27. .737 35. .509 1. .00 49. ,68 ISG 771
ATOM 771 N LEU 102 74. .042 28, .422 34. .514 1. .00 50. .91 ISG 772
ATOM 772 CA LEU 102 73. .939 29, .520 35. .423 1. .00 50. .91 ISG 773
ATOM 773 CB LEU 102 73. .939 30, .902 34. .750 1. .00 50. .91 ISG 774
ATOM 774 CG LEU 102 73, .789 32, .050 35. .764 1. .00 50. .91 ISG 775
ATOM 775 CD2 LEU 102 73. .477 33, .380 35. .061 1. ,00 50. .91 ISG 776
ATOM 776 CDl LEU 102 75. .006 32, .125 36, .697 1. .00 50. .91 ISG 777
ATOM 777 C LEU 102 72, .650 29, .449 36 .154 1, .00 50. .91 ISG 778
ATOM 778 0 LEU 102 71, .596 29 .219 35, .564 1, .00 50. .91 ISG 779
ATOM 779 N GLU 103 72. .712 29, .643 37, .483 1. .00 55, .26 ISG 780
ATOM 780 CA GLU 103 71, .507 29, .726 38. .251 1. .00 55. .26 ISG 781
ATOM 781 CB GLU 103 71, .228 28 .487 39. .119 1. .00 55 .26 ISG 782
ATOM 782 CG GLU 103 69 .886 28 .556 39 .854 1. .00 55. .26 ISG 783
ATOM 783 CD GLU 103 69. .544 27, .156 40, .345 1. .00 55, .26 ISG 784
ATOM 784 OEl GLU 103 70, .343 26, .225 40, .060 1. .00 55, .26 ISG 785
ATOM 785 OE2 GLU 103 68. .480 26, .997 41, .002 1. .00 55, .26 ISG 786
ATOM 786 C GLU 103 71 .720 30 .854 39 .198 1. .00 55 .26 ISG 787
ATOM 787 O GLU 103 72 .486 30 .715 40 .149 1. .00 55 .26 ISG 788
ATOM 788 N MET 104 71 .045 32, .002 38 .987 1. .00 58, .97 ISG 789
ATOM 789 CA MET 104 71. .318 33, .065 39, .906 1. .00 58. .97 ISG 790
ATOM 790 CB MET 104 71 .856 34 .361 39 .265 1. .00 58. .97 ISG 791
ATOM 791 CG MET 104 70 .828 35 .248 38 .570 1. .00 58 .97 ISG 792
ATOM 792 SD MET 104 71 .509 36 .866 38 .093 1. .00 58. .97 ISG 793
ATOM 793 CE MET 104 71, .800 37 .431 39, .797 1, .00 58. .97 ISG 794
ATOM 794 C MET 104 70 .077 33 .368 40 .656 1, .00 58 .97 ISG 795
ATOM 795 O MET 104 68 .990 33 .448 40 .085 1. .00 58. .97 ISG 796
ATOM 796 N PHE 105 70 .205 33 .524 41 .985 1. .00 64 .67 ISG 797
ATOM 797 CA PHE 105 69 .011 33 .822 4 .700 1, .00 64. .67 ISG 798
ATOM 798 CB PHE 105 68, .701 32 .939 43 .919 1, .00 64 .67 ISG 799
ATOM 799 CG PHE 105 68 .913 31 .503 43 .594 1. .00 64. .67 ISG 800
ATOM 800 CDl PHE 105 68 .260 30 .858 42 .568 1. .00 64, .67 ISG 801
ATOM 801 CD2 PHE 105 69 .770 30 .785 44 .391 1, .00 64, .67 ISG 802
ATOM 802 CE1 PHE 105 68 .498 29 .522 42 .330 1. .00 64 .67 ISG 803
ATOM 803 CE2 PHE 105 70 .008 29 .454 44 .159 1, .00 64 .67 ISG 804
ATOM 804 CZ PHE 105 69 .374 28 .818 43 .122 1. .00 64, .67 ISG 805
ATOM 805 C PHE 105 69, .223 35 .168 43 .284 1. .00 64, .67 ISG 806
ATOM 806 O PHE 105 70 .352 35 .593 43 .527 1, .00 64, .67 ISG 807
ATOM 807 N ALA 106 68 .112 35 .877 43 .517 1. .00 70 .82 ISG 808
ATOM 808 CA ALA 106 68 .196 37 .139 44 .153 1, .00 70, .82 ISG 809
ATOM 809 CB ALA 106 66 .851 37 .876 4 .267 1. .00 70. .82 ISG 810
ATOM 810 C ALA 106 68, .645 36 .796 45. .506 1. ,00 70. .82 ISG 811
ATOM 811 O ALA 106 68 .398 35 .678 45 .966 1. .00 70 .82 ISG 812
ATOM 812 N ALA 107 69 .341 37 .749 46 .148 1, .00 73. .89 ISG 813
ATOM 813 CA ALA 107 69 .821 37 .486 47 .455 1. .00 73, .89 ISG 814
ATOM 814 CB ALA 107 70, .446 38 .667 48 .187 1. .00 73. .89 ISG 815
ATOM 815 C ALA 107 68, .619 37, .164 48. .220 1. .00 73. .89 ISG 816
ATOM 816 O ALA 107 67 .521 37 .615 47 .894 1. .00 73, .89 ISG 817 ATOM 817 N ARG 108 68,.833 36..320 49..225 1..00 78..60 ISG 818
ATOM 818 CA ARG 108 67. .777 35. .846 50. .039 1. .00 78. .60 ISG 819
ATOM 819 CB ARG 108 68. .317 35. .108 51. .275 1. .00 78. .60 ISG 820
ATOM 820 CG ARG 108 69. .258 35. .992 52. .101 1. .00 78. .60 ISG 821
ATOM 821 CD ARG 108 70, .152 35. .227 53. .079 1. .00 78. .60 ISG 822
ATOM 822 NE ARG 108 70, .765 34. .089 52. .336 1. .00 78. .60 ISG 823
ATOM 823 CZ ARG 108 71, .843 34, .288 51, .523 1. .00 78, .60 ISG 824
ATOM 824 NHl ARG 108 72, .304 35, .552 51, .290 1. .00 78, .60 ISG 825
ATOM 825 NH2 ARG 108 72, .457 33, .219 50, .937 1. .00 78, .60 ISG 826
ATOM 826 C ARG 108 66, .996 37, .026 50. .493 1. .00 78, .60 ISG 827
ATOM 827 O ARG 108 67, .555 38, .042 50. .902 1. .00 78, .60 ISG 828
ATOM 828 N TRP 109 65, .662 36, .919 50. .357 1. .00 74, .47 ISG 829
ATOM 829 CA TRP 109 64, .769 37. .960 50, .764 1. .00 74, .47 ISG 830
ATOM 830 CB TRP 109 63, .740 38, .401 49. .704 1. .00 74, .47 ISG 831
ATOM 831 CG TRP 109 64, .203 39, .421 48, .693 1. .00 74, .47 ISG 832
ATOM 832 CD2 TRP 109 63, .714 40, .771 48, .675 1. .00 74, .47 ISG 833
ATOM 833 CDl TRP 109 65, .077 39, .313 47, .652 1, .00 74 .47 ISG 834
ATOM 834 NE1 TRP 109 65, .186 40, .523 47, .005 1. .00 74 .47 ISG 835
ATOM 835 CE2 TRP 109 64, .346 41, .425 47, .623 1, .00 74 .47 ISG 836
ATOM 836 CE3 TRP 109 62, .810 41, .412 49, .474 1, .00 74 .47 ISG 837
ATOM 837 CZ2 TRP 109 64, .086 42, .737 47, .358 1. .00 74 .47 ISG 838
ATOM 838 CZ3 TRP 109 62, .547 42, .736 49, .198 1. .00 74 .47 ISG 839
ATOM 839 CH2 TRP 109 63, .176 43, .387 48, .159 1, .00 74 .47 ISG 840
ATOM 840 C TRP 109 63, .953 37, .435 51, .889 1. .00 74 .47 ISG 841
ATOM 841 O TRP 109 63, .688 36, .237 51, .976 1. .00 74 .47 ISG 842
ATOM 842 N ARG 110 63 .545 38, .345 52, .793 1. .00 66 .61 ISG 843
ATOM 843 CA ARG 110 62, .694 37, .968 53, .878 1. .00 66 .61 ISG 844
ATOM 844 CB ARG 110 61, .280 37, .529 53, .455 1. .00 66 .61 ISG 845
ATOM 845 CG ARG 110 60. .359 38 .670 53, .026 1. .00 66 .61 ISG 846
ATOM 846 CD ARG 110 60. .772 39, .334 51, .717 1. .00 66 .61 ISG 847
ATOM 847 NE ARG 110 59, .637 40, .194 51, .287 1. .00 66 .61 ISG 848
ATOM 848 CZ ARG 110 58, .601 39 .597 50, .631 1, .00 66 .61 ISG 849
ATOM 849 NHl ARG 110 58, .600 38 .240 50, .491 1, .00 66 .61 ISG 850
ATOM 850 NH2 ARG 110 57, .582 40, .337 50, .103 1, .00 66 .61 ISG 851
ATOM 851 C ARG 110 63, .301 36 .830 54, .624 1, .00 66 .61 ISG 852
ATOM 852 O ARG 110 64 .299 36 .971 55, .329 1, .00 66 .61 ISG 853
ATOM 853 N SER 111 62, .648 35, .663 54, .465 1 .00 58 .72 ISG 854
ATOM 854 CA SER 111 62, .917 34, .418 55, .120 1, .00 58 .72 ISG 855
ATOM 855 CB SER 111 61, .868 33 .347 54, .792 1, .00 58 .72 ISG 856
ATOM 856 OG SER 111 60, .608 33 .738 55, .319 1, .00 58 .72 ISG 857
ATOM 857 C SER 111 64, .249 33, .888 54, .715 1, .00 58 .72 ISG 858
ATOM 858 O SER 111 64, .644 32, .816 55, .173 1, .00 58 .72 ISG 859
ATOM 859 N LYS 112 64, .975 34, .628 53, .856 1, .00 49 .32 ISG 860
ATOM 860 CA LYS 112 66, .285 34, .229 53, .427 1, .00 49 .32 ISG 861
ATOM 861 CB LYS 112 67, .154 33, .735 54, .592 1, .00 49, .32 ISG 862
ATOM 862 CG LYS 112 67, .213 34, .735 55, .743 1, .00 49 .32 ISG 863
ATOM 863 CD LYS 112 67, .734 34, .135 57, .049 1, .00 49, .32 ISG 864
ATOM 864 CE LYS 112 67, .786 35, .149 58, .191 1, .00 49, .32 ISG 865
ATOM 865 NZ LYS 112 68, .628 36, .297 57, .791 1, .00 49, .32 ISG 866
ATOM 866 C LYS 112 66, .171 33, .098 52, .462 1. .00 49, .32 ISG 867
ATOM 867 O LYS 112 67, .146 32, .390 52, .213 1, .00 49, .32 ISG 868
ATOM 868 N ALA 113 64, .977 32, .902 51, .876 1, .00 46, .34 ISG 869
ATOM 869 CA ALA 113 64, .853 31, .893 50, .872 1, .00 46, .34 ISG 870
ATOM 870 CB ALA 113 63. .400 31, .472 50, .598 1, .00 46, .34 ISG 871
ATOM 871 C ALA 113 65. .401 32, .494 49, .618 1, .00 46, .34 ISG 872
ATOM 872 O ALA 113 65. .349 33, .708 49. .428 1. .00 46, .34 ISG 873
ATOM 873 N PRO 114 65. .968 31, .676 48, .776 1. .00 47, .99 ISG 874 ATOM 874 CA PRO 114 66..474 32,.175 47..530 1..00 47..99 ISG 875
ATOM 875 CD PRO 114 66. .733 30, .536 49. .260 1. .00 47. .99 ISG 876
ATOM 876 CB PRO 114 67. .424 31. .103 47. .002 1. ,00 47. .99 ISG 877
ATOM 877 CG PRO 114 67. .896 30, .371 48. .269 1. .00 47. .99 ISG 878
ATOM 878 C PRO 114 65. .347 32, .424 46. .583 1. .00 47. .99 ISG 879
ATOM 879 O PRO 114 64. .395 31, .644 46. .582 1. .00 47. .99 ISG 880
ATOM 880 N MET 115 65. .428 33. .484 45. .756 1. ,00 50. .75 ISG 881
ATOM 881 CA MET 115 64. .401 33. .645 44. .770 1. .00 50. .75 ISG 882
ATOM 882 CB MET 115 63. .639 34. .977 44. .852 1. .00 50. .75 ISG 883
ATOM 883 CG MET 115 62. .850 35. .121 46, .156 1. .00 50. .75 ISG 884
ATOM 884 SD MET 115 61. .873 36. .647 46, .300 1. .00 50. .75 ISG 885
ATOM 885 CE MET 115 60. .550 36, .105 45, .179 1. .00 50. .75 ISG 886
ATOM 886 C MET 115 65. .125 33, .597 43, .473 1. .00 50. .75 ISG 887
ATOM 887 O MET 115 65, .970 34, .443 43 .200 1, .00 50, .75 ISG 888
ATOM 888 N SER 116 64. .825 32, .593 42, .635 1. .00 56, .22 ISG 889
ATOM 889 CA SER 116 65. .600 32, .436 41, .441 1. .00 56, .22 ISG 890
ATOM 890 CB SER 116 65, .400 31 .049 40 .799 1. .00 56, .22 ISG 891
ATOM 891 OG SER 116 66, .305 30, .854 39 .724 1. .00 56, .22 ISG 892
ATOM 892 C SER 116 65. .261 33, .505 40, .444 1. .00 56, .22 ISG 893
ATOM 893 O SER 116 64, .094 33 .715 40 .114 1, .00 56 .22 ISG 894
ATOM 894 N LEU 117 66, .290 34 .254 39 .984 1, .00 61 .99 ISG 895
ATOM 895 CA LEU 117 66. .120 35, .236 38 .945 1, .00 61, .99 ISG 896
ATOM 896 CB LEU 117 67. .318 36, .189 38 .846 1, .00 61, .99 ISG 897
ATOM 897 CG LEU 117 67, .433 37 .130 40 .059 1, .00 61 .99 ISG 898
ATOM 898 CD2 LEU 117 66, .130 37, .916 40 .284 1, .00 61 .99 ISG 899
ATOM 899 CDl LEU 117 68. .647 38, .059 39, .917 1, .00 61, .99 ISG 900
ATOM 900 C LEU 117 65, .956 34 .538 37 .623 1, .00 61 .99 ISG 901
ATOM 901 O LEU 117 65, .019 34, .808 36 .873 1, .00 61 .99 ISG 902
ATOM 902 N PHE 118 66. .883 33, .607 37 .312 1, .00 65, .30 ISG 903
ATOM 903 CA PHE 118 66, .813 32 .827 36 .108 1, .00 65 .30 ISG 904
ATOM 904 CB PHE 118 67. .089 33 .599 34 .804 1, .00 65 .30 ISG 905
ATOM 905 CG PHE 118 68. .361 34, .355 34 .946 1, .00 65 .30 ISG 906
ATOM 906 CDl PHE 118 69. .578 33 .717 34 .993 1 .00 65 .30 ISG 907
ATOM 907 CD2 PHE 118 68. .316 35 .729 35 .004 1, .00 65 .30 ISG 908
ATOM 908 CE1 PHE 118 70. .732 34, .455 35 .120 1, .00 65 .30 ISG 909
ATOM 909 CE2 PHE 118 69. .466 36, .468 35, .130 1, .00 65, .30 ISG 910
ATOM 910 CZ PHE 118 70, .679 35 .827 35 .191 1, .00 65 .30 ISG 911
ATOM 911 C PHE 118 67. .784 31, .689 36 .219 1, .00 65, .30 ISG 912
ATOM 912 O PHE 118 68. .835 31, .812 36, .847 1, .00 65, .30 ISG 913
ATOM 913 N LEU 119 67, .441 30 .531 35 .613 1, .00 68 .28 ISG 914
ATOM 914 CA LEU 119 68, .295 29, .378 35 .704 1, .00 68, .28 ISG 915
ATOM 915 CB LEU 119 67. .798 28, .351 36, .741 1. .00 68. .28 ISG 916
ATOM 916 CG LEU 119 68. .563 27 .008 36 .769 1, .00 68 .28 ISG 917
ATOM 917 CD2 LEU 119 70. .077 27, .241 36 .722 1, .00 68. .28 ISG 918
ATOM 918 CDl LEU 119 68. .119 26, .044 35, .659 1. .00 68. .28 ISG 919
ATOM 919 C LEU 119 68. .321 28 .692 34 .398 1, .00 68. .28 ISG 920
ATOM 920 O LEU 119 67, .280 28, .435 33, .796 1, .00 68. .28 ISG 921
ATOM 921 N LEU 120 69. .527 28. .359 33. .913 1, .00 67. .68 ISG 922
ATOM 922 CA LEU 120 69. .465 27. .626 32. .697 1. .00 67. .68 ISG 923
ATOM 923 CB LEU 120 69. .104 28, .494 31 .478 1. .00 67. .68 ISG 924
ATOM 924 CG LEU 120 69. .027 27. .721 30. .145 1. .00 67, .68 ISG 925
ATOM 925 CD2 LEU 120 68. .972 28. .688 28, .953 1. .00 67. .68 ISG 926
ATOM 926 CDl LEU 120 67. .865 26. .714 30, .135 1, .00 67. .68 ISG 927
ATOM 927 C LEU 120 70. .778 26. .985 32. .412 1, .00 67, .68 ISG 928
ATOM 928 0 LEU 120 71. .825 27. .432 32, .880 1. .00 67. .68 ISG 929
ATOM 929 N GLU 121 70. .729 25. .884 31, .634 1. .00 64, .00 ISG 930
ATOM 930 CA GLU 121 71. .930 25. .292 31, .128 1. .00 64. .00 ISG 931 ATOM 931 CB GLU 121 71.,894 23..754 30.,997 1.00 64.,00 ISG 932
ATOM 932 CG GLU 121 70. ,783 23. .198 30. .106 1. ,00 64. .00 ISG 933
ATOM 933 CD GLU 121 71. ,058 21. .713 29. .901 1. 00 64. ,00 ISG 934
ATOM 934 OEl GLU 121 71. ,372 21. .015 30. .904 1. ,00 64. .00 ISG 935
ATOM 935 OE2 GLU 121 70. .967 21. .258 28. .730 1. 00 64. ,00 ISG 936
ATOM 936 C GLU 121 72. .016 25. .908 29. .775 1. ,00 64. .00 ISG 937
ATOM 937 O GLU 121 71. .126 25. .721 28. .946 1. ,00 64. ,00 ISG 938
ATOM 938 N VAL 122 73. .080 26. .691 29. .518 1. ,00 60. .31 ISG 939
ATOM 939 CA VAL 122 73. .017 27, .484 28. .329 1. .00 60. .31 ISG 940
ATOM 940 CB VAL 122 73. .108 28. .951 28. .601 1. ,00 60. .31 ISG 941
ATOM 941 CGI VAL 122 71. .995 29, .364 29. .575 1. .00 60. .31 ISG 942
ATOM 942 CG2 VAL 122 74. .532 29, .238 29. .100 1. .00 60. .31 ISG 943
ATOM 943 C VAL 122 74. .171 27, .242 27, .431 1. .00 60. .31 ISG 944
ATOM 944 O VAL 122 75. .217 26. .732 27, .831 1. ,00 60. .31 ISG 945
ATOM 945 N HIS 123 73, .944 27, .642 26, .162 1. .00 55. .40 ISG 946
ATOM 946 CA HIS 123 74, .871 27, .638 25, .075 1. .00 55. .40 ISG 947
ATOM 947 NDl HIS 123 75, .849 24, .326 25. .061 1. .00 55, .40 ISG 948
ATOM 948 CG HIS 123 74, .728 25 .107 24. .891 1, .00 55, .40 ISG 949
ATOM 949 CB HIS 123 74, .703 26. .415 24. .157 1. .00 55. .40 ISG 950
ATOM 950 NE2 HIS 123 74, .174 23. .257 26. .061 1, .00 55. .40 ISG 951
ATOM 951 CD2 HIS 123 73, .714 24 .439 25 .509 1, .00 55, .40 ISG 952
ATOM 952 CE1 HIS 123 75, .461 23. .233 25. . 161 1, .00 55. .40 ISG 953
ATOM 953 C HIS 123 74 .451 28 .825 24 .256 1, .00 55 .40 ISG 954
ATOM 954 O HIS 123 73, .258 29. .042 24. .049 1, .00 55, .40 ISG 955
ATOM 955 N PHE 124 75, .405 29 .646 23 .780 1, .00 50 .75 ISG 956
ATOM 956 CA PHE 124 75, .023 30. .769 22, .971 1, .00 50, .75 ISG 957
ATOM 957 CB PHE 124 74 .658 32 .062 23, .736 1, .00 50 .75 ISG 958
ATOM 958 CG PHE 124 73 .269 31 .921 24, .269 1, .00 50 .75 ISG 959
ATOM 959 CDl PHE 124 72 .218 31 .777 23 .394 1, .00 50 .75 ISG 960
ATOM 960 CD2 PHE 124 73 .001 31 .975 25 .619 1 .00 50 .75 ISG 961
ATOM 961 CE1 PHE 124 70 .926 31 .655 23 .849 1, .00 50 .75 ISG 962
ATOM 962 CE2 PHE 124 71 .710 31 .855 26 .083 1 .00 50 .75 ISG 963
ATOM 963 CZ PHE 124 70 .671 31 .690 25, .199 1, .00 50 .75 ISG 964
ATOM 964 C PHE 124 76 .147 31 .085 22 .052 1 .00 50 .75 ISG 965
ATOM 965 O PHE 124 77 .131 30 .352 21 .979 1 .00 50 .75 ISG 966
ATOM 966 N ASN 125 75 .984 32 .183 21 .288 1, .00 47, .16 ISG 967
ATOM 967 CA ASN 125 76 .982 32 .620 20 .362 1 .00 47 .16 ISG 968
ATOM 968 CB ASN 125 76 .474 32 .694 18 .914 1, .00 47, .16 ISG 969
ATOM 969 CG ASN 125 77 .690 32 .747 18 .004 1, .00 47 .16 ISG 970
ATOM 970 ODl ASN 125 78 .826 32 .722 18, .474 1, .00 47, .16 ISG 971
ATOM 971 ND2 ASN 125 77 .449 32 .824 16 .668 1, .00 47 .16 ISG 972
ATOM 972 C ASN 125 77 .350 34 .001 20 .794 1 .00 47 .16 ISG 973
ATOM 973 O ASN 125 16 .539 34 .712 21 .386 1, .00 47 .16 ISG 974
ATOM 974 N LEU 126 78 .605 34 .407 20 .533 1 .00 44 .89 ISG 975
ATOM 975 CA LEU 126 79 .072 35 .664 21 .037 1, .00 44. .89 ISG 976
ATOM 976 CB LEU 126 79 .721 35 .418 22 .418 1, .00 44 .89 ISG 977
ATOM 977 CG LEU 126 80 .440 36 .580 23 .125 1, .00 44. .89 ISG 978
ATOM 978 CD2 LEU 126 81 .714 37 .003 22 .380 1, .00 44 .89 ISG 979
ATOM 979 CDl LEU 126 80 .782 36 .185 24 .571 1 .00 44 .89 ISG 980
ATOM 980 C LEU 126 80 .071 36 .226 20 .071 1, .00 44 .89 ISG 981
ATOM 981 0 LEU 126 80 .739 35 .488 19 .350 1 .00 44 .89 ISG 982
ATOM 982 N LYS 127 80 .190 37. .570 20 .030 1, .00 44 .80 ISG 983
ATOM 983 CA LYS 127 81 .141 38 .201 19 .161 1, .00 44 .80 ISG 984
ATOM 984 CB LYS 127 80 .587 39. .439 18 .434 1, .00 44. .80 ISG 985
ATOM 985 CG LYS 127 79 .668 39 .134 17 .249 1, .00 44 .80 ISG 986
ATOM 986 CD LYS 127 78 .370 38 .416 17 .619 1, .00 44 .80 ISG 987
ATOM 987 CE LYS 127 77 .316 38. .476 16 .510 1, .00 44. .80 ISG 988 ATOM 988 NZ LYS 127 77.950 38.850 15.225 1..00 44..80 ISG 989
ATOM 989 C LYS 127 82. .285 38, .674 20 .002 1. .00 44. .80 ISG 990
ATOM 990 O LYS 127 82 .097 39 .345 21 .015 1, .00 44. .80 ISG 991
ATOM 991 N VAL 128 83 .518 38 .323 19 .586 1, .00 44 .25 ISG 992
ATOM 992 CA VAL 128 84 .681 38 .738 20 .308 1. .00 44 .25 ISG 993
ATOM 993 CB VAL 128 85 .707 37 .648 20 .465 1. .00 44 .25 ISG 994
ATOM 994 CGI VAL 128 86 .042 37 .059 19 .082 1. .00 44 .25 ISG 995
ATOM 995 CG2 VAL 128 86 .927 38 .246 21 .190 1 .00 44 .25 ISG 996
ATOM 996 C VAL 128 85 .308 39 .848 19 .533 1, .00 44 .25 ISG 997
ATOM 997 O VAL 128 85 .694 39 .684 18 .378 1 .00 44 .25 ISG 998
ATOM 998 N GLN 129 85 .417 41 .031 20 .159 1, .00 44 .41 ISG 999
ATOM 999 CA GLN 129 86 .021 42 .140 19 .486 1, .00 44 .41 1SG1000
ATOM 1000 CB GLN 129 85 .265 43 .463 19 .708 1, .00 44 .41 1SG1001
ATOM 1001 CG GLN 129 85 .886 44 .665 18 .997 1, .00 44 .41 1SG1002
ATOM 1002 CD GLN 129 85 .665 44 .481 17 .505 1, .00 44 .41 1SG1003
ATOM 1003 OEl GLN 129 84 .558 44 .178 17 .065 1, .00 44 .41 1SG1004
ATOM 1004 NE2 GLN 129 86 .748 44 .653 16 .701 1, .00 44 .41 1SG1005
ATOM 1005 C GLN 129 87 .380 42 .288 20 .075 1, .00 44 .41 1SG1006
ATOM 1006 O GLN 129 87 .538 42 .260 21 .295 1, .00 44 .41 1SG1007
ATOM 1007 N TYR 130 88 .413 42 .432 19 .223 1, .00 44 .21 1SG1008
ATOM 1008 CA TYR 130 89 .718 42 .568 19 .785 1, .00 44 .21 1SG1009
ATOM 1009 CB TYR 130 90 .643 41 .347 19 .566 1, .00 44 .21 1SG1010
ATOM 1010 CG TYR 130 90 .850 41 .030 18 .122 1, .00 44 .21 1SG1011
ATOM 1011 CDl TYR 130 91 .866 41 .627 17 .413 1, .00 44 .21 1SG1012
ATOM 1012 CD2 TYR 130 90 .043 40 .116 17 .480 1, .00 44 .21 1SG1013
ATOM 1013 CE1 TYR 130 92 .065 41 .329 16 .085 1, .00 44 .21 1SG1014
ATOM 1014 CE2 TYR 130 90 .237 39 .814 16 .151 1, .00 44 .21 1SG1015
ATOM 1015 CZ TYR 130 91 .250 40 .422 15 .450 1, .00 44 .21 1ΞG1016
ATOM 1016 OH TYR 130 91 .455 40 .116 14 .087 1, .00 44 .21 1SG1017
ATOM 1017 C TYR 130 90. .363 43 .810 19 .270 1, .00 44 .21 1SG1018
ATOM 1018 O TYR 130 90. .231 44, .176 18 .103 1, .00 44 .21 1SG1019
ATOM 1019 N SER 131 91. .058 44, .504 20 .190 1, .00 41 .54 1SG1020
ATOM 1020 CA SER 131 91. .778 45, .702 19 .898 1, .00 41 .54 1SG1021
ATOM 1021 CB SER 131 91. .189 46 .961 20 .554 1, .00 41 .54 1SG1022
ATOM 1022 OG SER 131 89. .881 47, .199 20 .057 1, .00 41 .54 1SG1023
ATOM 1023 C SER 131 93. .118 45, .488 20 .501 1. .00 41 .54 1SG1024
ATOM 1024 O SER 131 93. .273 44, .681 21, .417 1. .00 41 .54 1SG1025
ATOM 1025 N VAL 132 94. .134 46, .194 19, .984 1, .00 41, .35 1SG1026
ATOM 1026 CA VAL 132 95, .436 45, .970 20, .508 1. .00 41, .35 1SG1027
ATOM 1027 CB VAL 132 96, .354 45, .285 19, .537 1. .00 41, .35 1SG1028
ATOM 1028 CGI VAL 132 95, .771 43, .904 19, .203 1. .00 41, .35 1SG1029
ATOM 1029 CG2 VAL 132 96, .540 46, .197 18, .311 1. .00 41, .35 1SG1030
ATOM 1030 C VAL 132 96, .061 47, .280 20, .786 1. .00 41, .35 1SG1031
ATOM 1031 O VAL 132 95, .716 48. .308 20, .205 1. .00 41. .35 1SG1032
ATOM 1032 N HIS 133 97. .008 47. .241 21. .728 1. .00 40. .49 1SG1033
ATOM 1033 CA HIS 133 97. .841 48. .346 22 , .045 1. ,00 40. .49 1SG1034
ATOM 1034 NDl HIS 133 95. .126 49. .164 23. .952 1. ,00 40. .49 1SG1035
ATOM 1035 CG HIS 133 96. .301 49. .687 23. .462 1. .00 40. .49 1SG1036
ATOM 1036 CB HIS 133 97. .604 48. .952 23. .435 1. .00 40. .49 1SG1037
ATOM 1037 NE2 HIS 133 94. .646 51. .192 23. .174 1. .00 40. .49 1SG1038
ATOM 1038 CD2 HIS 133 95. .991 50. .926 22. .993 1. .00 40. .49 1SG1039
ATOM 1039 CE1 HIS 133 94. .169 50. .105 23. .754 1. ,00 40. .49 1SG1040
ATOM 1040 C HIS 133 99. .190 47. .732 22. .002 1. ,00 40. ,49 1SG1041
ATOM 1041 O HIS 133 99. .305 46. .527 21. .784 1. ,00 40. ,49 1SG1042
ATOM 1042 N GLU 134 00. .250 48. .530 22. .180 1. ,00 38. ,28 1SG1043
ATOM 1043 CA GLU 134 01. ,546 47. .939 22. .074 1. 00 38. .28 1SG1044
ATOM 1044 CB GLU 134 02. ,675 48. ,955 22. ,303 1. 00 38. .28 1SG1045 ATOM 1045 CG GLU 134 102..625 49..612 23..685 1..00 38..28 1SG1046
ATOM 1046 CD GLU 134 103. .757 50. .624 23. .780 1. .00 38. .28 1SG1047
ATOM 1047 OEl GLU 134 103. .846 51. .493 22. .872 1. .00 38. .28 1SG1048
ATOM 1048 OE2 GLU 134 104. .545 50. .544 24. .760 1. .00 38. .28 1SG1049
ATOM 1049 C GLU 134 101. .663 46. .888 23. .124 1. .00 38. .28 1SG1050
ATOM 1050 O GLU 134 102. ,157 45. .794 22. .865 1. .00 38. .28 1SG1051
ATOM 1051 N ASN 135 101. ,205 47. ,205 24. .344 1. .00 36. .25 1SG1052
ATOM 1052 CA ASN 135 101. .333 46. .295 25. .437 1. .00 36, .25 1SG1053
ATOM 1053 CB ASN 135 101. .047 46. .962 26, .784 1. .00 36, .25 1SG1054
ATOM 1054 CG ASN 135 102. .180 47. .946 26, .983 1, .00 36, .25 1SG1055
ATOM 1055 ODl ASN 135 103. .336 47. .614 26, .726 1, .00 36. .25 1SG1056
ATOM 1056 ND2 ASN 135 101. .846 49. .188 27, .424 1. .00 36. .25 1SG1057
ATOM 1057 C ASN 135 100. .445 45. .100 25, .335 1. .00 36. .25 1SG1058
ATOM 1058 O ASN 135 100. .907 43. .982 25, .556 1. .00 36. .25 1SG1059
ATOM 1059 N GLN 136 99. .148 45. .262 25. .001 1. .00 32. .75 1SG1060
ATOM 1060 CA GLN 136 98. .396 44. .051 25. .157 1 .00 32. .75 1SG1061
ATOM 1061 CB GLN 136 97, .663 43. .940 26, .503 1. .00 32, .75 1SG1062
ATOM 1062 CG GLN 136 98, .571 43. .824 27, .725 1. .00 32. .75 1SG1063
ATOM 1063 CD GLN 136 97, .665 43. .620 28, .932 1, .00 32. .75 1SG1064
ATOM 1064 OEl GLN 136 96. .494 43. .994 28, .920 1, .00 32. .75 1SG1065
ATOM 1065 NE2 GLN 136 98. .221 42. .996 30, .005 1. .00 32. .75 1SG1066
ATOM 1066 C GLN 136 97. .327 43. .857 24 , .138 1. .00 32, .75 1SG1067
ATOM 1067 O GLN 136 97. .011 44, .718 23 .319 1 .00 32 .75 1SG1068
ATOM 1068 N LEU 137 96, .752 42. .640 24 .215 1 .00 28 .80 1SG1069
ATOM 1069 CA LEU 137 95, .669 42. .165 23 .416 1 .00 28 .80 1SG1070
ATOM 1070 CB LEU 137 95, .839 40. .670 23, .086 1 .00 28, .80 1SG1071
ATOM 1071 CG LEU 137 94, .727 40. .038 22 .232 1. .00 28, .80 1SG1072
ATOM 1072 CD2 LEU 137 94, .764 38. .503 22, .333 1. .00 28. .80 1SG1073
ATOM 1073 CDl LEU 137 94, .763 40. .551 20, .785 1. .00 28. .80 1SG1074
ATOM 1074 C LEU 137 94. .468 42. .276 24, .295 1. .00 28, .80 1SG1075
ATOM 1075 O LEU 137 94. .335 41. .530 25 .263 1 .00 28 .80 1SG1076
ATOM 1076 N GLN 138 93, .560 43, .221 23 .994 1 .00 26 .72 1SG1077
ATOM 1077 CA GLN 138 92, .413 43, .339 24 .844 1 .00 26 .72 1SG1078
ATOM 1078 CB GLN 138 92, .259 44, .731 25 .479 1. .00 26 .72 1SG1079
ATOM 1079 CG GLN 138 93, .389 45, .063 26, .458 1, .00 26, .72 1SG1080
ATOM 1080 CD GLN 138 93, .147 46, .458 27, .012 1, .00 26, .72 1SG1081
ATOM 1081 OEl GLN 138 92, .080 47. .037 26, .815 1, .00 26, .72 1SG1082
ATOM 1082 NE2 GLN 138 94. .165 47. .017 27. .719 1, .00 26, .72 ' 1SG1083
ATOM 1083 C GLN 138 91, .205 43, .064 24 .014 1 .00 26 .72 1SG1084
ATOM 1084 O GLN 138 91, .117 43, .500 22 .868 1 .00 26 .72 1SG1085
ATOM 1085 N MET 139 90, .239 42, .309 24. .580 1, .00 27, .01 1SG1086
ATOM 1086 CA MET 139 89, .066 41, .964 23 , .834 1, .00 27, .01 1SG1087
ATOM 1087 CB MET 139 89, .087 40. .525 23. .297 1, .00 27, .01 1SG1088
ATOM 1088 CG MET 139 90. .202 40. .295 22. .278 1, .00 27. .01 1SG1089
ATOM 1089 SD MET 139 90. .085 38. .740 21. .345 1. .00 27. .01 1SG1090
ATOM 1090 CE MET 139 90 .923 37. .718 22. .589 1, .00 27. .01 1SG1091
ATOM 1091 C MET 139 87. .869 42. .084 24. .720 1, .00 27. .01 1SG1092
ATOM 1092 O MET 139 87. .985 42, .248 25. .933 1, .00 27. .01 1SG1093
ATOM 1093 N ALA 140 86. .671 42, .024 24. .105 1, .00 28. .79 1SG1094
ATOM 1094 CA ALA 140 85, .440 42. .133 24, .830 1. .00 28. .79 1SG1095
ATOM 1095 CB ALA 140 84, .769 43. .508 24. .689 1, .00 28. .79 1SG1096
ATOM 1096 C ALA 140 84, .507 41. .130 24. .237 1, .00 28. .79 1SG1097
ATOM 1097 O ALA 140 84. .762 40. .601 23. .157 1, .00 28. .79 1SG1098
ATOM 1098 N THR 141 83. .401 40. .820 24. .942 1, .00 31. .83 1SG1099
ATOM 1099 CA THR 141 82. .494 39, .851 24. .401 1, .00 31. .83 1SG1100
ATOM 1100 CB THR 141 82. .321 38, .639 25. .264 1. .00 31. .83 1SG1101
ATOM 1101 OGl THR 141 81. .725 39. .001 26. .500 1, .00 31. .83 1SG1102
Figure imgf000603_0001
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H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H UJ tO tO tO tO tO tO tO tO tO tO H H H H H H H H H H O O O O O O O O O O o vD oo -j cn m i^ UJ tO H O D OO si _i ui 4* ui tO H o vo oo si en ui 4* uJ tO H O vD θθ si en ui ιi* uj -θ H θ vo oo si σι ui 4* uJ tθ H θ VD θθ si oι ui ιt*
ATOM 130 O VAL 17 125..264 33.,181 15.,164 1..00 33..10 ISG 131
ATOM 131 N GLN 18 124. .288 33. .390 13. .146 1. .00 34. .46 ISG 132
ATOM 132 CA GLN 18 125. .503 33. .820 12. .531 1. .00 34. .46 ISG 133
ATOM 133 CB GLN 18 125. .332 34. ,105 11. .038 1. .00 34. .46 ISG 134
ATOM 134 CG GLN 18 125. .045 32, .820 10. .266 1. .00 34. .46 ISG 135
ATOM 135 CD GLN 18 126. .333 32. .015 10. .168 1. .00 34. .46 ISG 136
ATOM 136 OEl GLN 18 127. .330 32. .343 10. .808 1. .00 34. .46 ISG 137
ATOM 137 NE2 GLN 18 126. .314 30. .935 9. .340 1. .00 34. .46 ISG 138
ATOM 138 C GLN 18 125. .988 35. .049 13, .218 1, .00 34. .46 ISG 139
ATOM 139 O GLN 18 127. .188 35. .190 13, .449 1. .00 34. .46 ISG 140
ATOM 140 N SER 19 125. .074 35. .963 13, .592 1. .00 34. .91 ISG 141
ATOM 141 CA SER 19 125. .525 37, .164 14, .230 1. .00 34. .91 ISG 142
ATOM 142 CB SER 19 124. .385 38. .122 14, .623 1. .00 34. .91 ISG 143
ATOM 143 OG SER 19 123. .618 37. .576 15. .684 1. .00 34, .91 ISG 144
ATOM 144 C SER 19 126, .251 36. .773 15. .479 1, .00 34, .91 ISG 145
ATOM 145 O SER 19 127, .294 37, .337 15. .807 1. .00 34, .91 ISG 146
ATOM 146 N ALA 20 125. .720 35, .777 16, .209 1. .00 37, .29 ISG 147
ATOM 147 CA ALA 20 126. .350 35. .336 17, .421 1. .00 37, .29 ISG 148
ATOM 148 CB ALA 20 125. .531 34. .262 18 .160 1 .00 37 .29 ISG 149
ATOM 149 C ALA 20 127. .690 34. .742 17, .097 1, .00 37 .29 ISG 150
ATOM 150 O ALA 20 128. .662 34. .938 17, .825 1, .00 37 .29 ISG 151
ATOM 151 N MET 21 127. .760 33 .994 15, .982 1 .00 40 .24 ISG 152
ATOM 152 CA MET 21 128. .941 33. .298 15 .547 1 .00 40 .24 ISG 153
ATOM 153 CB MET 21 128. .664 32, .386 14, .344 1, .00 40, .24 ISG 154
ATOM 154 CG MET 21 127. .734 31, .227 14, .702 1, .00 40, .24 ISG 155
ATOM 155 SD MET 21 127. .125 30 .279 13 .279 1 .00 40 .24 ISG 156
ATOM 156 CE MET 21 128, .724 29, .522 12, .872 1, .00 40 .24 ISG 157
ATOM 157 C MET 21 129. .991 34, .283 15, .161 1. .00 40, .24 ISG 158
ATOM 158 O MET 21 131. .187 34 .018 15' .270 1 .00 40 .24 ISG 159
ATOM 159 N ASP 22 129, .557 35 .458 14 .692 1 .00 41 .49 ISG 160
ATOM 160 CA ASP 22 130. .429 36, .472 14, .190 1, .00 41 .49 ISG 161
ATOM 161 CB ASP 22 129. .611 37, .733 13. .860 1, .00 41, .49 ISG 162
ATOM 162 CG ASP 22 130, .362 38 .617 12 .882 1 .00 41 .49 ISG 163
ATOM 163 ODl ASP 22 131, .621 38, .567 12. .857 1. .00 41 .49 ISG 164
ATOM 164 OD2 ASP 22 129. .667 39. .355 12. .134 1, .00 41, .49 ISG 165
ATOM 165 C ASP 22 131. .435 36 .807 15 .250 1 .00 41 .49 ISG 166
ATOM 166 O ASP 22 132, .629 36. .915 14, .972 1. .00 41 .49 ISG 167
ATOM 167 N GLU 23 130. .984 36. .931 16. .509 1, .00 43, .19 ISG 168
ATOM 168 CA GLU 23 131. .854 37. .309 17. .587 1, .00 43. .19 ISG 169
ATOM 169 CB GLU 23 131, .113 37. .353 18. .935 1, .00 43 .19 ISG 170
ATOM 170 CG GLU 23 132. .007 37. .685 20, .130 1, .00 43. .19 ISG 171
ATOM 171 CD GLU 23 132. .384 39. .157 20, .063 1, .00 43, .19 ISG 172
ATOM 172 OEl GLU 23 132. .094 39. .800 19, .019 1, .00 43. .19 ISG 173
ATOM 173 OE2 GLU 23 132. .969 39. .659 21, .061 1, .00 43. .19 ISG 174
ATOM 174 C GLU 23 132. .957 36. .306 17, .728 1, .00 43. .19 ISG 175
ATOM 175 O GLU 23 134. .118 36. .665 17, .910 1, .00 43. .19 ISG 176
ATOM 176 N SER 24 132. .631 35. .009 17, .649 1, .00 45. .04 ISG 177
ATOM 177 CA SER 24 133. .643 34. .009 17, .835 1, .00 45. .04 ISG 178
ATOM 178 CB SER 24 133. .074 32. .579 17, .843 1. .00 45. .04 ISG 179
ATOM 179 OG SER 24 132 , .546 32, .258 16, .566 1. .00 45, .04 ISG 180
ATOM 180 C SER 24 134. .633 34. .087 16. .717 1. .00 45, .04 ISG 181
ATOM 181 O SER 24 135. .836 33. .941 16. .932 1. .00 45, .04 ISG 182
ATOM 182 N HIS 25 134. .149 34. .344 15. .488 1. .00 47. .89 ISG 183
ATOM 183 CA HIS 25 134. .999 34. .334 14. .333 1. .00 47. .89 ISG 184
ATOM 184 NDl HIS 25 133. .754 32. .130 12. .243 1. .00 47. .89 ISG 185
ATOM 185 CG HIS 25 133. ,324 33. ,366 12. .672 1. .00 47. .89 ISG 186
ATOM 186 CB HIS 25 134. .237 34. .513 13. .006 1, .00 47. .89 ISG 187 ATOM 187 NE2 HIS 25 131..533 32..042 12..297 1.,00 47..89 ISG 188
ATOM 188 CD2 HIS 25 131. .964 33. .293 12, .698 1. .00 47. .89 ISG 189
ATOM 189 CE1 HIS 25 132. .644 31 .377 12, .033 1. .00 47. .89 ISG 190
ATOM 190 C HIS 25 136. .014 35 .430 14, .431 1. .00 47. .89 ISG 191
ATOM 191 O HIS 25 137. .156 35 .247 14, .014 1. .00 47. .89 ISG 192
ATOM 192 N ILE 26 135. .635 36 .592 14 .996 1. .00 51, .58 ISG 193
ATOM 193 CA ILE 26 136. .522 37 .724 15 .049 1. .00 51, .58 ISG 194
ATOM 194 CB ILE 26 135. .934 38 .964 15 .663 1. .00 51, .58 ISG 195
ATOM 195 CG2 ILE 26 134. .667 39 .318 14, .864 1. .00 51, .58 ISG 196
ATOM 196 CGI ILE 26 135, .687 38 .776 17 .166 1. .00 51, .58 ISG 197
ATOM 197 CDl ILE 26 135, .373 40 .074 17 .911 1. .00 51, .58 ISG 198
ATOM 198 C ILE 26 137. .744 37, .366 15. .843 1. .00 51. .58 ISG 199
ATOM 199 O ILE 26 138. .836 37. .857 15. .563 1. .00 51. .58 ISG 200
ATOM 200 N LEU 27 137. .579 36. .501 16, .860 1. .00 56. .72 ISG 201
ATOM 201 CA LEU 27 138. .606 36. .110 17, .792 1. .00 56. .72 ISG 202
ATOM 202 CB LEU 27 138. .091 35, .112 18, .845 1. .00 56. .72 ISG 203
ATOM 203 CG LEU 27 139. .162 34, .660 19, .857 1. ,00 56. .72 ISG 204
ATOM 204 CD2 LEU 27 138. .665 33, .470 20, .695 1. .00 56, .72 ISG 205
ATOM 205 CDl LEU 27 139. .657 35, .839 20, .713 1. .00 56, .72 ISG 206
ATOM 206 C LEU 27 139. .773 35, .444 17. .106 1. .00 56, .72 ISG 207
ATOM 207 O LEU 27 140. .901 35. .540 17, .586 1. .00 56, .72 ISG 208
ATOM 208 N GLU 28 139. .550 34. .745 15, .981 1. .00 59, .94 ISG 209
ATOM 209 CA GLU 28 140. .576 33. .967 15, .319 1. .00 59, .94 ISG 210
ATOM 210 CB GLU 28 140. .150 33 .492 13, .919 1. .00 59, .94 ISG 211
ATOM 211 CG GLU 28 138. .982 32. .505 13, .910 1. .00 59, .94 ISG 212
ATOM 212 CD GLU 28 138. .506 32 .376 12, .469 1. .00 59, .94 ISG 213
ATOM 213 OEl GLU 28 137. .839 33 .331 11, .985 1. .00 59, .94 ISG 214
ATOM 214 OE2 GLU 28 138. .802 31. .331 11, .831 1. .00 59, .94 ISG 215
ATOM 215 C GLU 28 141. .842 34. .760 15, .122 1. .00 59, .94 ISG 216
ATOM 216 O GLU 28 141, .822 35, .988 15, .063 1. .00 59, .94 ISG 217
ATOM 217 N LYS 29 143 , .002 34, .053 15, .062 1. .00 62, .94 ISG 218
ATOM 218 CA LYS 29 144, .283 34, .689 14, .863 1. .00 62, .94 ISG 219
ATOM 219 CB LYS 29 145, .208 34, .573 16, .086 1. .00 62, .94 ISG 220
ATOM 220 CG LYS 29 144, .650 35. .230 17, .348 1, .00 62, .94 ISG 221
ATOM 221 CD LYS 29 145, .366 34, .789 18, .627 1. .00 62, .94 ISG 222
ATOM 222 CE LYS 29 145, .018 33 .365 19, .068 1. .00 62, .94 ISG 223
ATOM 223 NZ LYS 29 145, .756 33 .022 20, .305 1. .00 62, .94 ISG 224
ATOM 224 C LYS 29 145, .010 33 .986 13, .746 1. .00 62, .94 ISG 225
ATOM 225 O LYS 29 145, .141 32, .763 13, .761 1. .00 62, .94 ISG 226
ATOM 226 N MET 30 145, .511 34 .746 12, .743 1. .00 67, .86 ISG 227
ATOM 227 CA MET 30 146, .254 34 .166 11, .647 1 , .00 67, .86 ISG 228
ATOM 228 CB MET 30 145, .418 33 .925 10, .379 1. .00 67, .86 ISG 229
ATOM 229 CG MET 30 144, .298 32 .898 10, .563 1. .00 67, .86 ISG 230
ATOM 230 SD MET 30 142, .902 33 .484 11, .570 1. .00 67. .86 ISG 231
ATOM 231 CE MET 30 141, .823 32 .065 11, .224 1. .00 67. .86 ISG 232
ATOM 232 C MET 30 147, .364 35 .121 11, .275 1. .00 67. .86 ISG 233
ATOM 233 O MET 30 147, .246 36 .323 11, .501 1. .00 67. .86 ISG 234
ATOM 234 N ALA 31 148, .467 34, .598 10, .682 1. .00 68. .28 ISG 235
ATOM 235 CA ALA 31 149. .672 35, .330 10, .337 1. .00 68. .28 ISG 236
ATOM 236 CB ALA 31 150, .936 34, .451 10, .312 1. .00 68, .28 ISG 237
ATOM 237 C ALA 31 149, .578 36, .025 8, .995 1. .00 68, .28 ISG 238
ATOM 238 O ALA 31 148, .569 35, .910 8, .307 1. .00 68, .28 ISG 239
ATOM 239 N ALA 32 150. .648 36, .797 8, .627 1. .00 68. .79 ISG 240
ATOM 240 CA ALA 32 150. .808 37, .588 7, .409 1. .00 68. .79 ISG 241
ATOM 241 CB ALA 32 150. .409 39, .065 7. .578 1. .00 68, .79 ISG 242
ATOM 242 C ALA 32 152. .288 37, .547 6, .971 1. .00 68, .79 ISG 243
ATOM 243 O ALA 32 153. .025 36. .739 7. .529 1. 00 68. ,79 ISG 244 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H HHH H H H H H H H H H H H H H H H H H H P OP PPP P P P PP PP PPP P PPPP PPO PP P POPP POP PP PPP PPOP P PP OPO P PPOQ OPQ
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ATOM 358 C THR 48 144,.294 37.822 5,.708 1,.00139..11 ISG 359
ATOM 359 O THR 48 143, .573 38 .274 4. .808 1. .00139. .11 ISG 360
ATOM 360 N ASN 49 144, .193 36 .559 6, .151 1, .00146, .45 ISG 361
ATOM 361 CA ASN 49 143, .022 35 .859 5. .770 1. .00146. .45 ISG 362
ATOM 362 CB ASN 49 142 .935 34 .433 6, .331 1, .00146. .45 ISG 363
ATOM 363 CG ASN 49 143, .056 34, .497 7. .841 1, .00146. .45 ISG 364
ATOM 364 ODl ASN 49 144 .010 35 .089 8. .341 1 .00146. .45 ISG 365
ATOM 365 ND2 ASN 49 142, .074 33, .912 8. .577 1, .00146, .45 ISG 366
ATOM 366 C ASN 49 142 .018 36 .720 6. .415 1 .00146, .45 ISG 367
ATOM 367 O ASN 49 140, .957 36, .979 5. .857 1, .00146, .45 ISG 368
ATOM 368 N LEU 50 142 .350 37 .209 7. .626 1 .00149, .13 ISG 369
ATOM 369 CA LEU 50 141, .476 38, .221 8. .082 1, .00149, .13 ISG 370
ATOM 370 CB LEU 50 140 .068 37 .642 8, .353 1 .00149, .13 ISG 371
ATOM 371 CG LEU 50 138. .923 38, .663 8, .451 1, .00149, .13 ISG 372
ATOM 372 CD2 LEU 50 138 .852 39 .534 7, .187 1 .00149, .13 ISG 373
ATOM 373 CDl LEU 50 138. .997 39, .479 9, .735 1, .00149, .13 ISG 374
ATOM 374 C LEU 50 142 .050 38 .753 9, .345 1 .00149 .13 ISG 375
ATOM 375 O LEU 50 142. .298 37 .991 10, .280 1, .00149. .13 ISG 376
ATOM 376 N LYS 51 142 .358 40 .066 9 .351 1 .00139 .28 ISG 377
ATOM 377 CA LYS 51 142. . 611 40, .753 10, .564 1, .00139. .28 ISG 378
ATOM 378 CB LYS 51 143 .487 42 .042 10 .342 1 .00139 .28 ISG 379
ATOM 379 CG LYS 51 144. .041 42, .665 11, .627 1 .00139. .28 ISG 380
ATOM 380 CD LYS 51 145 .058 43 .781 11 .372 1 .0013 .28 ISG 381
ATOM 381 CE LYS 51 146. .312 43, .311 10, .633 1 .00139, .28 ISG 382
ATOM 382 NZ LYS 51 147 .106 44 .475 10 .182 1 .0013 .28 ISG 383
ATOM 383 C LYS 51 141. .299 41 .135 10. .893 1 .00139, .28 ISG 384
ATOM 384 O LYS 51 140 .606 41 .673 10 .030 1 .00139 .28 ISG 385
ATOM 385 N VAL 52 140, .844 40, .862 12. .118 1, .00128, .19 ISG 386
ATOM 386 CA VAL 52 139 .434 40 .989 12 .207 1 .00128 .19 ISG 387
ATOM 387 CB VAL 52 138, .820 40 .115 13. .260 1, .00128, .19 ISG 388
ATOM 388 CGI VAL 52 137, .308 40. .395 13. .307 1, .00128, .19 ISG 389
ATOM 389 CG2 VAL 52 139, .174 38 .651 12. .954 1, .00128, .19 ISG 390
ATOM 390 C VAL 52 139, .051 42, .379 12. .532 1, .00128, .19 ISG 391
ATOM 391 O VAL 52 138, .854 42 .704 13. .699 1, .00128, .19 ISG 392
ATOM 392 N LYS 53 138. .995 43, .252 11. .509 1, .00115, .43 ISG 393
ATOM 393 CA LYS 53 138. .448 44 .549 11. .738 1 .00115, .43 ISG 394
ATOM 394 CB LYS 53 138. .848 45, .558 10. .653 1, .00115. .43 ISG 395
ATOM 395 CG LYS 53 140. .362 45 .764 10, .657 1, .00115. .43 ISG 396
ATOM 396 CD LYS 53 140. .892 46, .225 12. .018 1. .00115. .43 ISG 397
ATOM 397 CE LYS 53 142. .383 45, .950 12. .224 1, .00115. .43 ISG 398
ATOM 398 NZ LYS 53 143. .161 46, .472 11. .079 1. .00115. .43 ISG 399
ATOM 399 C LYS 53 136. .966 44, .393 11, .774 1. .00115. .43 ISG 400
ATOM 400 O LYS 53 136. .296 44, .849 12. .701 1. .00115. .43 ISG 401
ATOM 401 N ASP 54 136. .434 43, .699 10. .743 1. .00105. .03 ISG 402
ATOM 402 CA ASP 54 135. .038 43, .421 10. .644 1. .00105. .03 ISG 403
ATOM 403 CB ASP 54 134. .249 44, .432 9. .789 1. .00105. .03 ISG 404
ATOM 404 CG ASP 54 134. .766 44. .379 8. .361 1. .00105. .03 ISG 405
ATOM 405 ODl ASP 54 136. .014 44. .338 8. .189 1. .00105. .03 ISG 406
ATOM 406 OD2 ASP 54 133. .923 44. .353 7. .426 1. .00105. .03 ISG 407
ATOM 407 C ASP 54 134. .910 42. .067 10. .011 1. .00105. .03 ISG 408
ATOM 408 O ASP 54 135. .442 41. .794 8. ,933 1. .00105. .03 ISG 409
ATOM 409 N VAL 55 134. .242 41. .148 10. .725 1. .00 98. .72 ISG 410
ATOM 410 CA VAL 55 133. .955 39. .876 10. ,156 1. .00 98. .72 ISG 411
ATOM 411 CB VAL 55 134. .041 38, .736 11. .122 1. .00 98. .72 ISG 412
ATOM 412 CGI VAL 55 133. .583 37. .460 10. .394 1. .00 98. .72 ISG 413
ATOM 413 CG2 VAL 55 135. ,472 38. .665 11. .679 1. .00 98. .72 ISG 414
ATOM 414 C VAL 55 132. 535 40. .026 9. .801 1. ,00 98. .72 ISG 415 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H O O P P P O P P P P P O O P P P P P O P P P P P P O P O P P P O P P P O O O O P P O P O P P P P O P P O P P P O P 2 3 2 3 2 2 2 2 2 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 22 2 2 2
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O O O O O VD VO VD VD VO VD VO VO ID IO VO VD IO VO VD OO OO CD CO OO OO CD OO OO CO OO OO OO OO OO OO IO VO VD VD
4* 4* 00 00 03 00 CD CD CD CD VD VO VD VO VD VO V0 00 03 0J 00 00 01 01 01 01 01 Cn Cn O O O O O O O O VD VD lO VO VD VO VO VD sl sl sl sl sl sl sl sl sl sl sl sl tO tO M tO tO tO tO tO IO M VD VO lO VD VO VO lD OO CD CD CO CD tO tO tO tO tO tO tO OO OO CD CO CO CD CD OO Ul ln ln Ul Ul Ul Ul Ul in Ul Ul Ul U^
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H totototototototototototototomtototototototototototototototototototototototototototototototototowtotototototototo Ώ ΩΩΩ ΩΩ Ω Ω Ώ Ώ Ω Ω ΩΩ ΏΩ ΏΩΏ ΩΩ ΩΩΩΩΏ ΩΩΏ ΩΩ ΩΩΩ ΩΩ ΩΩΏ Ώ Ω ΩΩ Ω ΩΏ Ω ΩΩ Ω ΩΩΩΩ ΩΩΩ sl s] -J s] sl ^ J ^ ^ .O -J ^ -J ^ ^ ^ ^ ^ ^ J ^ ^ -j -j ^ -j ^ ^ ^ ^ ^ ^ J ^ ^ ^ ^ ^ ^ -J -j ^ .g .J -J .J .J sl s] sJ sl sl s] sJ l sl sl Ul Ul Ul Ul Ul Ul Ul Ul Λ 4* 4* 4* 4* 4* 4* 4* ι^ 4* Ul UJ Ul UJ UI Ul UJ UI UI UJ tO tO tO tO t tO tO M tO tO H H H H H H H H H H O O O O O O O O O si σι ιn 4* uJ tθ H θ vo oo si cn ui ι^ u tθ H θ vo o3 si cn uι 4* uj H θ vD θθ si σι uι 4* ι tθ H θ vD θθ si σi (n ιt* uJ tθ H θ i) <D si cn ιn 4* uι co H
ATOM 757 CB ARG 103 122..930 16,.051 14..724 1..00 37..42 ISG 758
ATOM 758 CG ARG 103 122. .107 14, .772 14. .873 1. ,00 37. .42 ISG 759
ATOM 759 CD ARG 103 122 .948 13 .534 15, .185 1. .00 37. .42 ISG 760
ATOM 760 NE ARG 103 122, .008 12, .385 15. .294 1. .00 37. .42 ISG 761
ATOM 761 CZ ARG 103 121, .582 11, .746 14. .166 1. .00 37. .42 ISG 762
ATOM 762 NHl ARG 103 122 .022 12 .159 12, .942 1. .00 37. .42 ISG 763
ATOM 763 NH2 ARG 103 120 .709 10 .700 14, .266 1. .00 37. .42 ISG 764
ATOM 764 C ARG 103 121, .105 17, .605 15. .291 1. .00 37. .42 ISG 765
ATOM 765 O ARG 103 121 .430 18 .241 16. .293 1, .00 37. .42 ISG 766
ATOM 766 N LEU 104 119 .841 17 .208 15. .065 1. .00 36, .03 ISG 767
ATOM 767 CA LEU 104 118, .783 17, .530 15. .976 1. .00 36. .03 ISG 768
ATOM 768 CB LEU 104 117 .500 1 .957 15, .242 1, .00 36. .03 ISG 769
ATOM 769 CG LEU 104 117 .645 19 .252 14, .426 1, .00 36. .03 ISG 770
ATOM 770 CD2 LEU 104 118 .136 20, .409 15. .311 1. .00 36. .03 ISG 771
ATOM 771 CDl LEU 104 116 .339 19 .591 13, .690 1, .00 36. .03 ISG 772
ATOM 772 C LEU 104 118 .428 16 .285 16, .722 1. .00 36. .03 ISG 773
ATOM 773 O LEU 104 118 .259 15, .222 16, .126 1. .00 36. .03 ISG 774
ATOM 774 N LEU 105 118 .319 16 .388 18, .061 1, .00 34 .47 ISG 775
ATOM 775 CA LEU 105 117 .943 15 .248 18, .846 1. .00 34. .47 ISG 776
ATOM 116 CB LEU 105 119 .125 14, .524 19, .517 1. .00 34. .47 ISG 777
ATOM 111 CG LEU 105 120 .141 13 .918 18 .528 1, .00 34 .47 ISG 778
ATOM l l β CD2 LEU 105 119 .450 12 .999 17, .508 1. .00 34. .47 ISG 779
ATOM 119 CDl LEU 105 121 .293 13, .212 19, .265 1. .00 34. .47 ISG 780
ATOM 780 C LEU 105 117 .028 15 .731 19 .924 1. .00 34 .47 ISG 781
ATOM 781 O LEU 105 116 .720 16 .918 20, .010 1. .00 34. .47 ISG 782
ATOM 782 N ARG 106 116 .544 14 .795 20, .763 1. .00 35. .04 ISG 783
ATOM 783 CA ARG 106 115 .651 15 .146 21 .828 1. .00 35 .04 ISG 784
ATOM 784 CB ARG 106 114 .230 14 .592 21, .627 1, .00 35 .04 ISG 785
ATOM 785 CG ARG 106 113 .290 14, .872 22, .800 1. .00 35. .04 ISG 786
ATOM 786 CD ARG 106 111 .976 14 .098 22 .707 1. .00 35 .04 ISG 787
ATOM 787 NE ARG 106 112 .328 12 .657 22, .563 1. .00 35 .04 ISG 788
ATOM 788 CZ ARG 106 111, .585 11, .703 23, .196 1. .00 35. .04 ISG 789
ATOM 789 NHl ARG 106 110 .529 12 .072 23 .978 1, .00 35 .04 ISG 790
ATOM 790 NH2 ARG 106 111 .896 10 .382 23. .049 1, .00 35 .04 ISG 791
ATOM 791 C ARG 106 116, .169 14, .536 23, .090 1. .00 35. .04 ISG 792
ATOM 792 O ARG 106 116 .850 13 .512 23 .069 1. .00 35 .04 ISG 793
ATOM 793 N ASP 107 115 .861 15 .183 24, .232 1. .00 35. .14 ISG 794
ATOM 794 CA ASP 107 116, .231 14, .653 25. .511 1. .00 35, .14 ISG 795
ATOM 795 CB ASP 107 116 .779 15 .712 26. .484 1. .00 35 .14 ISG 796
ATOM 796 CG ASP 107 117, .317 15, .009 27. .726 1. .00 35, .14 ISG 797
ATOM 797 ODl ASP 107 116, .590 14, .156 28. .301 1. .00 35. .14 ISG 798
ATOM 798 OD2 ASP 107 118 .467 15 .327 28. .126 1. .00 35. .14 ISG 799
ATOM 799 C ASP 107 114 .965 14, .109 26, .090 1. .00 35. .14 ISG 800
ATOM 800 O ASP 107 114, .034 14, .849 26. .386 1. .00 35. .14 ISG 801
ATOM 801 N GLU 108 114 .898 12, .776 26. .240 1. .00 34. .76 ISG 802
ATOM 802 CA GLU 108 113, .708 12, .131 26. .711 1. .00 34. .76 ISG 803
ATOM 803 CB GLU 108 113, .859 10, .602 26. .715 1. .00 34. .76 ISG 804
ATOM 804 CG GLU 108 114 .106 10 .011 25. .326 1. .00 34. .76 ISG 805
ATOM 805 CD GLU 108 114, .448 8, .537 25. .500 1. .00 34. .76 ISG 806
ATOM 806 OEl GLU 108 114, .013 7, .949 26. .525 1. ,00 34. .76 ISG 807
ATOM 807 OE2 GLU 108 115 .153 7 .980 24. .616 1. .00 34. .76 ISG 808
ATOM 808 C GLU 108 113, .402 12, .526 28. .122 1. ,00 34. .76 ISG 809
ATOM 809 O GLU 108 112, .261 12, .852 28. .446 1. ,00 34. .76 ISG 810
ATOM 810 N GLU 109 114, .410 12, .509 29. .014 1. ,00 36. .07 ISG 811
ATOM 811 CA GLU 109 114 , .114 12, .772 30. .393 1. .00 36. ,07 ISG 812
ATOM 812 CB GLU 109 115. .352 12. .657 31. .296 1. 00 36. ,07 ISG 813
ATOM 813 CG GLU 109 115. .049 12, .931 32. .770 1. ,00 36. .07 ISG 814 ATOM 814 CD GLU 109 116..377 13..003 33..509 1..00 36..07 ISG 815
ATOM 815 OEl GLU 109 117. .384 13. .407 32. .869 1. .00 36. .07 ISG 816
ATOM 816 OE2 GLU 109 116. .403 12. .657 34. .720 1. .00 36. .07 ISG 817
ATOM 817 C GLU 109 113. .596 14. .164 30. .565 1. .00 36 .07 ISG 818
ATOM 818 O GLU 109 112. .564 14. .368 31. .203 1. .00 36. .07 ISG 819
ATOM 819 N THR 110 114. .333 15. .154 30. .022 1. .00 36. .66 ISG 820
ATOM 820 CA THR 110 114. .026 16. .553 30. .158 1. .00 36 .66 ISG 821
ATOM 821 CB THR 110 115. .207 17. .419 29. .824 1. .00 36 .66 ISG 822
ATOM 822 OGl THR 110 116. .326 17. .055 30. .620 1. .00 36 .66 ISG 823
ATOM 823 CG2 THR 110 114. .833 18, .878 30. .123 1. .00 36 .66 ISG 824
ATOM 824 C THR 110 112. .877 16. .971 29. .286 1. .00 36 .66 ISG 825
ATOM 825 O THR 110 112. .036 17. .773 29. .694 1. .00 36 .66 ISG 826
ATOM 826 N GLY 111 112. .812 16. .451 28. .048 1. .00 37 .24 ISG 827
ATOM 827 CA GLY 111 111. .778 16. .853 27. .138 1. .00 37 .24 ISG 828
ATOM 828 C GLY 111 112. .267 18. .042 26. .364 1. .00 37 .24 ISG 829
ATOM 829 O GLY 111 111. .495 18. .681 25. .651 1. .00 37 .24 ISG 830
ATOM 830 N LEU 112 113. .569 18. .378 26. .479 1. .00 40 .48 ISG 831
ATOM 831 CA LEU 112 114. .085 19. .509 25. .755 1. .00 40 .48 ISG 832
ATOM 832 CB LEU 112 114. .967 20. .443 26. .601 1. .00 40 .48 ISG 833
ATOM 833 CG LEU 112 114. .143 21. .337 27. .549 1. .00 40 .48 ISG 834
ATOM 834 CD2 LEU 112 113. .133 20. .510 28. .358 1. .00 40 .48 ISG 835
ATOM 835 CDl LEU 112 113. .448 22. .472 26. .780 1. .00 40, .48 ISG 836
ATOM 836 C LEU 112 114, .851 19. .031 24. .563 1. .00 40 .48 ISG 837
ATOM 837 O LEU 112 115, .378 17. .920 24. .523 1. .00 40 .48 ISG 838
ATOM 838 N PRO 113 114, .867 19. .867 23. .559 1, .00 43 .01 ISG 839
ATOM 839 CA PRO 113 115, .525 19, .543 22. .325 1. .00 43 .01 ISG 840
ATOM 840 CD PRO 113 113, .825 20, .864 23. .380 1. .00 43 .01 ISG 841
ATOM 841 CB PRO 113 114. .906 20, .451 21. .263 1, .00 43 .01 ISG 842
ATOM 842 CG PRO 113 114. .192 21, .557 22. .060 1, .00 43 .01 ISG 843
ATOM 843 C PRO 113 117, .004 19, .683 22, .439 1. .00 43 .01 ISG 844
ATOM 844 O PRO 113 117, .472 20, .418 23, .306 1, .00 43 .01 ISG 845
ATOM 845 N VAL 114 117. .762 18, .977 21, .578 1. .00 45 .14 ISG 846
ATOM 846 CA VAL 114 119. .182 19. .138 21, .628 1. .00 45 .14 ISG 847
ATOM 847 CB VAL 114 119. .934 17, .980 22, .217 1. .00 45 .14 ISG 848
ATOM 848 CGI VAL 114 119. .536 17. .832 23, .696 1, .00 45 .14 ISG 849
ATOM 849 CG2 VAL 114 119. .662 16. .740 21, .364 1. .00 45 .14 ISG 850
ATOM 850 C VAL 114 119. .665 19, .391 20, .238 1. .00 45 .14 ISG 851
ATOM 851 O VAL 114 119. .010 19, .045 19. .255 1. .00 45, .14 ISG 852
ATOM 852 N PHE 115 120. .829 20, .056 20. .144 1. .00 46, .86 ISG 853
ATOM 853 CA PHE 115 121. .416 20. .474 18. .908 1. .00 46, .86 ISG 854
ATOM 854 CB PHE 115 121. .139 21. .985 18. .756 1. .00 46, .86 ISG 855
ATOM 855 CG PHE 115 121. .669 22. .628 17. .520 1. ,00 46, .86 ISG 856
ATOM 856 CDl PHE 115 123. .015 22. .683 17. .272 1. .00 46, .86 ISG 857
ATOM 857 CD2 PHE 115 120. .807 23. .244 16. .641 1. .00 46, .86 ISG 858
ATOM 858 CE1 PHE 115 123. .500 23. .307 16. .146 1. .00 46. .86 ISG 859
ATOM 859 CE2 PHE 115 121, .283 23, .872 15. .513 1. .00 46. .86 ISG 860
ATOM 860 CZ PHE 115 122. .635 23, .905 15. .263 1. .00 46, .86 ISG 861
ATOM 861 C PHE 115 122. .895 20, .269 19. .093 1. .00 46, .86 ISG 862
ATOM 862 O PHE 115 123. .465 20, .707 20, .093 1. .00 46, .86 ISG 863
ATOM 863 N LYS 116 123. .561 19, .589 18, .139 1. .00 44, .84 ISG 864
ATOM 864 CA LYS 116 124. .973 19, .357 18, .281 1. .00 44, .84 ISG 865
ATOM 865 CB LYS 116 125. .309 17, .937 18, .773 1. .00 44, .84 ISG 866
ATOM 866 CG LYS 116 126. .805 17, .685 18. .972 1. .00 44, .84 ISG 867
ATOM 867 CD LYS 116 127. .402 18. .467 20. .143 1. ,00 44, .84 ISG 868
ATOM 868 CE LYS 116 128. .893 18. .202 20. .359 1. ,00 44, .84 ISG 869
ATOM 869 NZ LYS 116 129. .099 16. .819 20. .846 1. .00 44 , .84 ISG 870
ATOM 870 C LYS 116 125. ,590 19. .509 16. .929 1. .00 44. .84 ISG 871 ATOM 871 O LYS 116 124,.890 19,.484 15..918 1,.00 44.84 ISG 872
ATOM 872 N SER 117 126, .927 19. .686 16. .875 1. .00 43. .57 ISG 873
ATOM 873 CA SER 117 127, .553 19, .809 15, .594 1. .00 43, .57 ISG 874
ATOM 874 CB SER 117 128, .588 20, .948 15 .527 1 .00 43 .57 ISG 875
ATOM 875 OG SER 117 129, .673 20, .677 16 .402 1. .00 43 .57 ISG 876
ATOM 876 C SER 117 128, .258 18, .517 15 .321 1. .00 43, .57 ISG 877
ATOM 877 O SER 117 129 .226 18 .165 15 .995 1 .00 43 .57 ISG 878
ATOM 878 N GLU 118 127, .752 17, .756 14 .331 1 .00 42 .46 ISG 879
ATOM 879 CA GLU 118 128, .337 16. .492 13 .997 1, .00 42, .46 ISG 880
ATOM 880 CB GLU 118 127 .481 15 .644 13 .045 1 .00 42 .46 ISG 881
ATOM 881 CG GLU 118 128, .021 14, .219 12 .892 1, .00 42 .46 ISG 882
ATOM 882 CD GLU 118 127, .114 13, .460 11 .936 1, .00 42, .46 ISG 883
ATOM 883 OEl GLU 118 126. .376 14, .133 11, .168 1. .00 42, .46 ISG 884
ATOM 884 OE2 GLU 118 127. .148 12, .201 11 .955 1. .00 42 .46 ISG 885
ATOM 885 C GLU 118 129. .654 16. .697 13 .326 1, .00 42, .46 ISG 886
ATOM 886 O GLU 118 130. .627 16. .014 13, .642 1. .00 42, .46 ISG 887
ATOM 887 N GLY 119 129 .728 17 .650 12 .377 1. .00 45 .04 ISG 888
ATOM 888 CA GLY 119 130. .973 17. .808 11 .687 1. .00 45 .04 ISG 889
ATOM 889 C GLY 119 131, .053 19. .186 11, .126 1. .00 45, .04 ISG 890
ATOM 890 O GLY 119 130 .042 19 .828 10 .844 1, .00 45 .04 ISG 891
ATOM 891 N CYS 120 132, .299 19 .665 10 .950 1, .00 51 .73 ISG 892
ATOM 892 CA CYS 120 132, .531 20. .966 10 .411 1, .00 51 .73 ISG 893
ATOM 893 CB CYS 120 133, .075 21, .962 11 .447 1, .00 51 .73 ISG 894
ATOM 894 SG CYS 120 133, .547 23, .565 10 .734 1. .00 51 .73 ISG 895
ATOM 895 C CYS 120 133, .573 20, .830 9, .364 1. .00 51 .73 ISG 896
ATOM 896 O CYS 120 134. .538 20, .081 9. .511 1. .00 51, .73 ISG 897
ATOM 897 N GLU 121 133 .380 21 .555 8 .255 1. .00 58 .38 ISG 898
ATOM 898 CA GLU 121 134, .364 21, .545 7. .228 1. .00 58 .38 ISG 899
ATOM 899 CB GLU 121 134, .111 20, .499 6, .130 1. .00 58, .38 ISG 900
ATOM 900 CG GLU 121 134 .274 19 .061 6 .630 1. .00 58 .38 ISG 901
ATOM 901 CD GLU 121 134, .005 18, .121 5, .465 1. .00 58 .38 ISG 902
ATOM 902 OEl GLU 121 134, .698 18, .264 4, .422 1. .00 58, .38 ISG 903
ATOM 903 OE2 GLU 121 133 .109 17, .246 5 .601 1. .00 58 .38 ISG 904
ATOM 904 C GLU 121 134, .306 22, .890 6 .609 1. .00 58 .38 ISG 905
ATOM 905 O GLU 121 133, .240 23 , .406 6, .280 1. .00 58, .38 ISG 906
ATOM 906 N VAL 122 135 .480 23, .502 6 .450 1. .00 65 .89 ISG 907
ATOM 907 CA VAL 122 135, .561 24, .788 5, .858 1. .00 65, .89 ISG 908
ATOM 908 CB VAL 122 136, .365 25, .680 6. .731 1. .00 65, .89 ISG 909
ATOM 909 CGI VAL 122 135. .442 26. .281 7, .807 1. ,00 65. .89 ISG 910
ATOM 910 CG2 VAL 122 137, .328 24, .708 7, .432 1. .00 65, .89 ISG 911
ATOM 911 C VAL 122 136, .163 24. .568 4 , .511 1. .00 65, .89 ISG 912
ATOM 912 O VAL 122 136. .991 23. .679 4 , .326 1. .00 65. .89 ISG 913
ATOM 913 N ILE 123 135. .671 25. .310 3, .503 1. .00 69, .07 ISG 914
ATOM 914 CA ILE 123 136, .197 25. .181 2, .178 1. .00 69. .07 ISG 915
ATOM 915 CB ILE 123 135. .343 24. .336 1. .282 1. .00 69. .07 ISG 916
ATOM 916 CG2 ILE 123 135. .282 22, .920 1, .876 1. .00 69, .07 ISG 917
ATOM 917 CGI ILE 123 133. .961 24. .982 1. .097 1. .00 69. .07 ISG 918
ATOM 918 CDl ILE 123 133. .140 24. .354 -0. .027 1. ,00 69. .07 ISG 919
ATOM 919 C ILE 123 136. .215 26, .554 1. .597 1. .00 69. .07 ISG 920
ATOM 920 O ILE 123 135. .260 27. .308 1, .764 1. .00 69. .07 ISG 921
ATOM 921 N LEU 124 137. .299 26. ,922 0. .890 1. .00 70. .81 ISG 922
ATOM 922 CA LEU 124 137, .341 28. .238 0. .323 1. .00 70, .81 ISG 923
ATOM 923 CB LEU 124 138, .718 28. .918 0. .405 1. ,00 70. .81 ISG 924
ATOM 924 CG LEU 124 139. .302 28. .972 1. .824 1. ,00 70. .81 ISG 925
ATOM 925 CD2 LEU 124 140. .447 29. .991 1. .929 1. 00 70. ,81 ISG 926
ATOM 926 CDl LEU 124 139. .682 27. .565 2. .307 1. ,00 70. .81 ISG 927
ATOM 927 C LEU 124 137. ,065 28. .079 -1. .135 1. .00 70. ,81 ISG 928 > > > > !> > > > > > > > > | |> > > > > > > > > > > > |> > > Ϊ=| > > > > > 5| > ' >' > > ' > > > H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H O O P P P P P P P P P O O O P P O O P P P P P P P P P O P P O P P P P O P P P P P P P P P P P P P P P P O P P P O 2222 32 222 2 2222 2 2222 222222222222 222 2222222 222 2333333 33 333 3
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ATOM 1156 O PRO 153 138..939 25..648 9..441 1..00 65..64 1SG1157
ATOM 1157 N GLY 154 141. ,168 26. .003 9. .342 1. .00 61. .47 1SG1158
ATOM 1158 CA GLY 154 141. .379 25. .246 10. .537 1. .00 61. .47 1SG1159
ATOM 1159 C GLY 154 140. .788 25. .983 11, .698 1. .00 61. .47 1SG1160
ATOM 1160 O GLY 154 140. .137 25. .382 12, .545 1. .00 61. .47 1SG1161
ATOM 1161 N LEU 155 141. .009 27. .309 11. .782 1. .00 60. .29 1SG1162
ATOM 1162 CA LEU 155 140. .542. 28. .073 12, .909 1. .00 60. .29 1SG1163
ATOM 1163 CB LEU 155 141, .101 29, .510 12, .959 1, .00 60. .29 1SG1164
ATOM 1164 CG LEU 155 142. .603 29, .569 13, .311 1, .00 60, .29 1SG1165
ATOM 1165 CD2 LEU 155 143. .044 30. .991 13. .688 1. .00 60. .29 1SG1166
ATOM 1166 CDl LEU 155 143. .475 28. .949 12. .211 1. .00 60. .29 1SG1167
ATOM 1167 C LEU 155 139, .047 28, .154 12. .970 1, .00 60. .29 1SG1168
ATOM 1168 O LEU 155 138, .459 28, .053 14, .047 1, .00 60. .29 1SG1169
ATOM 1169 N MET 156 138. .379 28, .337 11, .819 1. .00 58. .77 1SG1170
ATOM 1170 CA MET 156 136, .958 28, .540 11, .861 1. .00 58, .77 1SG1171
ATOM 1171 CB MET 156 136, .329 28, .802 10 .483 1, .00 58, .77 1SG1172
ATOM 1172 CG MET 156 136. .649 30, .182 9, .914 1. .00 58. .77 1SG1173
ATOM 1173 SD MET 156 135, .888 30. .501 8, .296 1. .00 58. .77 1SG1174
ATOM 1174 CE MET 156 136, .159 32, .295 8 .350 1, .00 58. .77 1SG1175
ATOM 1175 C MET 156 136, .241 27 .357 12 .442 1, .00 58. .77 1SG1176
ATOM 1176 o MET 156 135, .326 27, .528 13 , .246 1, .00 58. .77 1SG1177
ATOM 1177 N CYS 157 136, .623 26, .121 12, .072 1, .00 59. .33 1SG1178
ATOM 1178 CA CYS 157 135, .851 25, .004 12 .547 1, .00 59. .33 1SG1179
ATOM 1179 CB CYS 157 136, .279 23 .645 11 .967 1, .00 59 .33 1SG1180
ATOM 1180 SG CYS 157 135, .530 23, .341 10, .341 1, .00 59. .33 1SG1181
ATOM 1181 C CYS 157 135, .861 24, .913 14, .042 1, .00 59, .33 1SG1182
ATOM 1182 O CYS 157 134, .811 24 .687 14 .641 1, .00 59, .33 1SG1183
ATOM 1183 N PRO 158 136, .978 25 .078 14 .686 1. .00 60 .48 1SG1184
ATOM 1184 CA PRO 158 136, .929 24, .985 16, .111 1. .00 60, .48 1SG1185
ATOM 1185 CD PRO 158 138, .154 24, .373 14, .234 1, .00 60, .48 1SG1186
ATOM 1186 CB PRO 158 138, .385 24 .950 16 .585 1. .00 60 .48 1SG1187
ATOM 1187 CG PRO 158 139, .205 24, .747 15, .291 1. .00 60. .48 1SG1188
ATOM 1188 C PRO 158 136. .067 26, .023 16, .751 1, .00 60. .48 1SG1189
ATOM 1189 O PRO 158 135, .581 25. .785 17, .856 1, .00 60. .48 1SG1190
ATOM 1190 N ALA 159 135, .856 27 .171 16 .087 1, .00 58 .63 1SG1191
ATOM 1191 CA ALA 159 135. .032 28. .217 16, .625 1, .00 58. .63 1SG1192
ATOM 1192 CB ALA 159 134, .981 29. .455 15, .713 1, .00 58, .63 1SG1193
ATOM 1193 C ALA 159 133, .633 27, .695 16, .766 1, .00 58. .63 1SG1194
ATOM 1194 O ALA 159 132, .902 28 .027 17 .699 1, .00 58. .63 1SG1195
ATOM 1195 N ILE 160 133. .256 26. .802 15, .845 1. .00 56, .71 1SG1196
ATOM 1196 CA ILE 160 131. .942 26. .249 15, .677 1. .00 56, .71 1SG1197
ATOM 1197 CB ILE 160 131, .930 25. .130 14, .679 1. .00 56, .71 1SG1198
ATOM 1198 CG2 ILE 160 130, .494 24 .584 14 .597 1, .00 56, .71 1SG1199
ATOM 1199 CGI ILE 160 132. .485 25. .615 13 , .330 1. .00 56. .71 1SG1200
ATOM 1200 CDl ILE 160 131. .709 26. .787 12, .732 1. .00 56. .71 1SG1201
ATOM 1201 C ILE 160 131. .437 25. .675 16 .978 1. .00 56. .71 1SG1202
ATOM 1202 O ILE 160 130, .227 25, .595 17. .181 1. .00 56. .71 1SG1203
ATOM 1203 N ASP 161 132. .338 25, .263 17, .894 1. .00 53. .02 1SG1204
ATOM 1204 CA ASP 161 132. .014 24, .603 19, .137 1. .00 53. .02 1SG1205
ATOM 1205 CB ASP 161 133, .251 24, .345 20, .020 1. .00 53. .02 1SG1206
ATOM 1206 CG ASP 161 133. .935 25, .663 20. .358 1. .00 53. ,02 1SG1207
ATOM 1207 ODl ASP 161 133. .383 26, .740 20. .007 1. .00 53. .02 1SG1208
ATOM 1208 OD2 ASP 161 135. .037 25, .603 20, .966 1. .00 53. .02 1SG1209
ATOM 1209 C ASP 161 130. .997 25, .391 19, .913 1. .00 53. .02 1SG1210
ATOM 1210 O ASP 161 130. ,374 24. .878 20, .842 1. ,00 53. ,02 1SG1211
ATOM 1211 N ALA 162 130. .787 26. .663 19. .543 1. .00 48. .42 1SG1212
ATOM 1212 CA ALA 162 129. .837 27. .502 20. .214 1. .00 48. .42 1SG1213 ATOM 1213 CB ALA 162 129..643 28,.859 19..516 1..00 48..42 1SG1214
ATOM 1214 C ALA 162 128. .511 26, .801 20. .212 1. .00 48. .42 1SG1215
ATOM 1215 O ALA 162 127, .688 27, .019 21. .098 1. .00 48. .42 1SG1216
ATOM 1216 N VAL 163 128 .247 25 .953 19. .203 1. .00 46, .53 1SG1217
ATOM 1217 CA VAL 163 126, .979 25 .280 19. .126 1. .00 46, .53 1SG1218
ATOM 1218 CB VAL 163 126. .987 24, .252 18. .036 1. .00 46. .53 1SG1219
ATOM 1219 CGI VAL 163 125, .719 23, .403 18, .160 1. .00 46. .53 1SG1220
ATOM 1220 CG2 VAL 163 127, .139 24, .970 16, .684 1. .00 46. .53 1SG1221
ATOM 1221 C VAL 163 126, .698 24 .560 20, .411 1. .00 46. .53 1SG1222
ATOM 1222 O VAL 163 125 .661 24 .775 21, .037 1. .00 46 .53 1SG1223
ATOM 1223 N LEU 164 127, .623 23, .711 20, .876 1. .00 46. .18 1SG1224
ATOM 1224 CA LEU 164 127, .303 22, ,975 22. .061 1. .00 46. .18 1SG1225
ATOM 1225 CB LEU 164 128, .415 21, .993 22. .464 1. .00 46. .18 1SG1226
ATOM 1226 CG LEU 164 128 .085 21 .196 23 .740 1. .00 46. .18 1SG1227
ATOM 1227 CD2 LEU 164 129 .317 20 .447 24, .271 1. .00 46 .18 1SG1228
ATOM 1228 CDl LEU 164 126, .871 20, .277 23, .530 1. .00 46, .18 1SG1229
ATOM 1229 C LEU 164 127, .091 23 .913 23, .206 1. .00 46, .18 1SG1230
ATOM 1230 O LEU 164 126, .085 23 .821 23 .907 1. .00 46, .18 1SG1231
ATOM 1231 N VAL 165 128 .030 24 .851 23 .437 1. .00 46 .88 1SG1232
ATOM 1232 CA VAL 165 127 .853 25 .698 24, .579 1. .00 46 .88 1SG1233
ATOM 1233 CB VAL 165 129, .072 26, .529 24, .878 1. .00 46, .88 1SG1234
ATOM 1234 CGI VAL 165 129, .491 27 .309 23 .619 1. .00 46 .88 1SG1235
ATOM 1235 CG2 VAL 165 128, .750 27 .436 26 .079 1, .00 46 .88 1SG1236
ATOM 1236 C VAL 165 126, .668 26 .614 24 .452 1, .00 46 .88 1SG1237
ATOM 1237 O VAL 165 125, .747 26, .545 25, .261 1. .00 46, .88 1SG1238
ATOM 1238 N TYR 166 126, .684 27, .519 23, .452 1. .00 48, .96 1SG1239
ATOM 1239 CA TYR 166 125, .673 28 .525 23 .259 1, .00 48 .96 1SG1240
ATOM 1240 CB TYR 166 126, .175 29 .707 22 .409 1. .00 48 .96 1SG1241
ATOM 1241 CG TYR 166 127 .116 30 .524 23 .226 1. .00 48 .96 1SG1242
ATOM 1242 CDl TYR 166 128, .432 30, .153 23. .380 1. .00 48, .96 1SG1243
ATOM 1243 CD2 TYR 166 126, .674 31, .678 23 .831 1. .00 48, .96 1SG1244
ATOM 1244 CE1 TYR 166 129, .292 30 .917 24, .135 1. .00 48 .96 1SG1245
ATOM 1245 CE2 TYR 166 127, .528 32 .446 24 .585 1, .00 48 .96 1SG1246
ATOM 1246 CZ TYR 166 128 .839 32 .065 24 .739 1. .00 48 .96 1SG1247
ATOM 1247 OH TYR 166 129, .716 32, .852 25, .514 1. .00 48, .96 1SG1248
ATOM 1248 C TYR 166 124, .373 28, .097 22 .639 1, .00 48, .96 1SG1249
ATOM 1249 O TYR 166 123, .312 28, .395 23, .184 1. .00 48 .96 1SG1250
ATOM 1250 N VAL 167 124, .404 27 .416 21 .471 1. .00 48, .26 1SG1251
ATOM 1251 CA VAL 167 123 .152 27 .223 20 .785 1. .00 48 .26 1SG1252
ATOM 1252 CB VAL 167 123. .248 26, .813 19, .336 1. .00 48, .26 1SG1253
ATOM 1253 CGI VAL 167 124, .080 27, .867 18, .585 1. .00 48, .26 1SG1254
ATOM 1254 CG2 VAL 167 123, .732 25, .366 19 .206 1, .00 48, .26 1SG1255
ATOM 1255 C VAL 167 122, .248 26 .274 21 .494 1, .00 48, .26 1SG1256
ATOM 1256 O VAL 167 121, .044 26 .510 21 .582 1, .00 48, .26 1SG1257
ATOM 1257 N ASN 168 122. .800 25, .173 22, .027 1. .00 47. .11 1SG1258
ATOM 1258 CA ASN 168 121. .965 24, .188 22 .646 1. .00 47. .11 1SG1259
ATOM 1259 CB ASN 168 122. .768 22 .992 23 .187 1. .00 47. .11 1SG1260
ATOM 1260 CG ASN 168 121, .785 21 .918 23 .629 1. .00 47. .11 1SG1261
ATOM 1261 ODl ASN 168 120, .902 22 .158 24 .451 1. .00 47. .11 1SG1262
ATOM 1262 ND2 ASN 168 121. .939 20. .692 23 .062 1. .00 47. .11 1SG1263
ATOM 1263 C ASN 168 121. .232 24. .802 23 .798 1. .00 47. .11 1SG1264
ATOM 1264 O ASN 168 120, .032 24. .593 23, .964 1. .00 47. .11 1SG1265
ATOM 1265 N ARG 169 121, .936 25. .597 24 .618 1. .00 47. .07 1SG1266
ATOM 1266 CA ARG 169 121. ,353 26, .171 25, .797 1. .00 47, .07 1SG1267
ATOM 1267 CB ARG 169 122. .364 26. .960 26, .644 1. ,00 47. ,07 1SG1268
ATOM 1268 CG ARG 169 123. .014 28. .128 25. .904 1. .00 47. ,07 1SG1269
ATOM 1269 CD ARG 169 124. .016 28. .886 26, .773 1. .00 47. .07 1SG1270 ATOM 1270 NE ARG 169 124..886 27..861 27..415 1.00 47..07 1SG1271
ATOM 1271 CZ ARG 169 126. .067 28. .225 27. ,992 1. 00 47. .07 1SG1272
ATOM 1272 NHl ARG 169 126. ,469 29. ,529 27. 969 1. 00 47. .07 1SG1273
ATOM 1273 NH2 ARG 169 126. .848 27. .281 28. ,594 1. 00 47. .07 1SG1274
ATOM 1274 C ARG 169 120. .234 27. .099 25. ,440 1. 00 47. ,07 1SG1275
ATOM 1275 O ARG 169 119. .242 27. .177 26. ,162 1. 00 47. .07 1SG1276
ATOM 1276 N LYS 170 120. .371 27. .851 24. ,334 1. .00 45. .35 1SG1277
ATOM 1277 CA LYS 170 119. .370 28. .814 23. .961 1. .00 45. .35 1SG1278
ATOM 1278 CB LYS 170 119, .771 29, .607 22. .707 1. ,00 45. .35 1SG1279
ATOM 1279 CG LYS 170 121, .028 30. .459 22. .887 1. ,00 45, .35 1SG1280
ATOM 1280 CD LYS 170 121, .612 30, .959 21. .565 1. .00 45, .35 1SG1281
ATOM 1281 CE LYS 170 122. .864 31. .820 21. .736 1. .00 45. .35 1SG1282
ATOM 1282 NZ LYS 170 123. .414 32. .180 20. .410 1. 00 45. .35 1SG1283
ATOM 1283 C LYS 170 118. .076 28. .125 23. .641 1. .00 45, .35 1SG1284
ATOM 1284 O LYS 170 117. .003 28, .568 24. .046 1. .00 45. .35 1SG1285
ATOM 1285 N TRP 171 118. .163 27. .004 22. .908 1. ,00 45. .29 1SG1286
ATOM 1286 CA TRP 171 117. .061 26. .224 22. .413 1. ,00 45, .29 1SG1287
ATOM 1287 CB TRP 171 117 .568 25. .074 21. .524 1. .00 45 .29 1SG1288
ATOM 1288 CG TRP 171 116 .520 2 .279 20. .786 1. .00 45 .29 1SG1289
ATOM 1289 CD2 TRP 171 116 .844 23 .194 19. .902 1. .00 45 .29 1SG1290
ATOM 1290 CDl TRP 171 115. .162 24. .399 20. .771 1. .00 45, .29 1SG1291
ATOM 1291 NE1 TRP 171 114. .618 23, .457 19. .928 1. .00 45, .29 1SG1292
ATOM 1292 CE2 TRP 171 115. .643 22, .709 19. .389 1. .00 45, .29 1SG1293
ATOM 1293 CE3 TRP 171 118 .044 22 .649 19. .552 1. .00 45 .29 1SG1294
ATOM 1294 CZ2 TRP 171 115 .626 21 .661 18. .511 1. .00 45 .29 1SG1295
ATOM 1295 CZ3 TRP 171 118 .024 21 .595 18, .665 1. .00 45 .29 1SG1296
ATOM 1296 CH2 TRP 171 116 .837 21 .111 18, .155 1. .00 45 .29 1SG1297
ATOM 1297 C TRP 171 116 .312 25 .640 23, .570 1, .00 45 .29 1SG1298
ATOM 1298 O TRP 171 115 .139 25 .291 23 .455 1. .00 45 .29 1SG1299
ATOM 1299 N THR 172 117. .015 25. .473 24, .700 1. .00 43 .30 1SG1300
ATOM 1300 CA THR 172 116 .530 24, .913 25, .930 1. .00 43 .30 1SG1301
ATOM 1301 CB THR 172 117 .626 24 .690 26, .930 1. .00 43 .30 1SG1302
ATOM 1302 OGl THR 172 118 .614 23 .826 26, .388 1. .00 43 .30 1SG1303
ATOM 1303 CG2 THR 172 117 .017 24 .061 28. .194 1. .00 43 .30 1SG1304
ATOM 1304 C THR 172 115 .528 25 .833 26 .560 1. .00 43 .30 1SG1305
ATOM 1305 O THR 172 114 .758 25 .414 27 .419 1, .00 43 .30 1SG1306
ATOM 1306 N ASN 173 115 .550 27 .126 26 .191 1. .00 41 .72 1SG1307
ATOM 1307 CA ASN 173 114 .685 28 .128 26 .752 1. .00 41 .72 1SG1308
ATOM 1308 CB ASN 173 114, .970 29 .548 26. .228 1. .00 41 .72 1SG1309
ATOM 1309 CG ASN 173 116 .256 30 .035 26. .885 1. .00 41, .72 1SG1310
ATOM 1310 ODl ASN 173 116 .752 29 .418 27. .827 1. .00 41 .72 1SG1311
ATOM 1311 ND2 ASN 173 116 .803 31 .180 26. .395 1. .00 41 .72 1SG1312
ATOM 1312 C ASN 173 113 .250 27 .803 26 .465 1. .00 41 .72 1SG1313
ATOM 1313 O ASN 173 112 .357 28 .305 27 .146 1. .00 41 .72 1SG1314
ATOM 1314 N LEU 174 112 .979 26 .989 25 .428 1. .00 43 .42 1SG1315
ATOM 1315 CA LEU 174 111 .621 26 .679 25 .081 1. .00 43 .42 1SG1316
ATOM 1316 CB LEU 174 111 .525 25 .669 23 .921 1, .00 43 .42 1SG1317
ATOM 1317 CG LEU 174 110 .094 25 .417 23, .410 1. .00 43, .42 1SG1318
ATOM 1318 CD2 LEU 174 110 .050 24 .221 22, .444 1. .00 43 .42 1SG1319
ATOM 1319 CDl LEU 174 109 .492 26 .695 22. .802 1. .00 43 .42 1SG1320
ATOM 1320 C LEU 174 110 .927 26 .114 26 .293 1. .00 43 .42 1SG1321
ATOM 1321 O LEU 174 111 .491 25 .311 27 .037 1. .00 43 .42 1SG1322
ATOM 1322 N SER 175 109 .668 26 .551 26 .530 1. .00 46 .45 1SG1323
ATOM 1323 CA SER 175 108 .928 26 .157 27 .700 1. .00 46 .45 1SG1324
ATOM 1324 CB SER 175 107 .601 26 .921 27 .873 1. .00 46 .45 1SG1325
ATOM 1325 OG SER 175 106 .934 26 .470 29 .043 1. .00 46 .45 1SG1326
ATOM 1326 C SER 175 108, .586 24, .701 27. .643 1. .00 46, .45 1SG1327 ATOM 1327 O SER 175 108..076 24..196 26.,645 1.00 46..45 1SG1328
ATOM 1328 N ASP 176 108. .844 23, .993 28. .759 1. .00 51. .83 1SG1329
ATOM 1329 CA ASP 176 108. .545 22, .597 28. .844 1. .00 51. .83 1SG1330
ATOM 1330 CB ASP 176 109. .770 21. .793 29. .329 1. .00 51. .83 1SG1331
ATOM 1331 CG ASP 176 109. .540 20. .334 28. ,984 1. 00 51. ,83 1SG1332
ATOM 1332 ODl ASP 176 108. .777 20, .086 28. .013 1. .00 51. .83 1SG1333
ATOM 1333 OD2 ASP 176 110, .131 19 .455 29. .665 1. .00 51, .83 1SG1334
ATOM 1334 C ASP 176 107, .337 22 .514 29. .748 1. .00 51. .83 1SG1335
ATOM 1335 O ASP 176 106. .251 22. .331 29. .195 1. .00 51. ,83 1SG1336
ATOM 1336 N PRO 177 107. .376 22, .554 31. .072 1. .00 54. .68 1SG1337
ATOM 1337 CA PRO 177 106, .120 22 .770 31. .735 1. .00 54, .68 1SG1338
ATOM 1338 CD PRO 177 108, .227 21 .685 31, .881 1. .00 54. .68 1SG1339
ATOM 1339 CB PRO 177 106, .181 22 .064 33, .090 1. .00 54. .68 1SG1340
ATOM 1340 CG PRO 177 107. .676 21, .794 33. .309 1. .00 54, .68 1SG1341
ATOM 1341 C PRO 177 105. .919 2 .247 31, .840 1. .00 54, .68 1SG1342
ATOM 1342 O PRO 177 106. .779 24 .912 32. .416 1. .00 54, .68 1SG1343
ATOM 1343 N MET 178 104. .786 24 .794 31, .371 1. .00 53, .29 1SG1344
ATOM 1344 CA MET 178 104. .648 26, .213 31. .503 1. .00 53, .29 1SG1345
ATOM 1345 CB MET 178 104, .357 26 .921 30. .168 1, .00 53. .29 1SG1346
ATOM 1346 CG MET 178 104, .373 28 .445 30. .284 1, .00 53, .29 1SG1347
ATOM 1347 SD MET 178 106 .025 29 .152 30. .562 1. .00 53, .29 1SG1348
ATOM 1348 CE MET 178 105 .440 30 .859 30, .769 1. .00 53. .29 1SG1349
ATOM 1349 C MET 178 103. .489 26 .476 32, .411 1. .00 53, .29 1SG1350
ATOM 1350 O MET 178 102. .344 26 .193 32, .060 1. .00 53, .29 1SG1351
ATOM 1351 N PRO 179 103. .766 26 .957 33, .597 1. .00 48 .43 1SG1352
ATOM 1352 CA PRO 179 102, .682 27 .309 34, .477 1, .00 48, .43 1SG1353
ATOM 1353 CD PRO 179 104. .906 26 .436 34, .336 1. .00 48 .43 1SG1354
ATOM 1354 CB PRO 179 103 .267 27 .339 35, .887 1. .00 48. .43 1SG1355
ATOM 1355 CG PRO 179 104, .452 26 .360 35, .804 1. .00 48 .43 1SG1356
ATOM 1356 C PRO 179 102 .032 28 .596 34, .064 1. .00 48 .43 1SG1357
ATOM 1357 O PRO 179 102 .725 29 .611 33 .995 1 .00 48 .43 1SG1358
ATOM 1358 N VAL 180 100, .713 28 .573 33, .778 1. .00 42 .80 1SG1359
ATOM 1359 CA VAL 180 99, .955 29 .742 33. .421 1. .00 42, .80 1SG1360
ATOM 1360 CB VAL 180 98, .681 29 .417 32. .701 1. .00 42 .80 1SG1361
ATOM 1361 CGI VAL 180 97, .911 30, .728 32 .464 1 .00 42 .80 1SG1362
ATOM 1362 CG2 VAL 180 99 .026 28 .655 31 .411 1 .00 42 .80 1SG1363
ATOM 1363 C VAL 180 99 .584 30 .540 34. .627 1. .00 42, .80 1SG1364
ATOM 1364 0 VAL 180 99, .599 31, .771 34. .604 1, .00 42, .80 1SG1365
ATOM 1365 N GLY 181 99, .208 29. .839 35, .713 1. .00 38 .88 1SG1366
ATOM 1366 CA GLY 181 98 .747 30 .504 36 .892 1 .00 38 .88 1SG1367
ATOM 1367 C GLY 181 98, .797 29, .505 37, .992 1. .00 38, .88 1SG1368
ATOM 1368 0 GLY 181 99, .479 28, .488 37, .896 1. .00 38, .88 1SG1369
ATOM 1369 N GLN 182 98, .083 29, .781 39. .094 1. .00 38, .62 1SG1370
ATOM 1370 CA GLN 182 98, .127 28 .862 40, .185 1. .00 38 .62 1SG1371
ATOM 1371 CB GLN 182 97 .423 29 .376 41 .452 1. .00 38 .62 1SG1372
ATOM 1372 CG GLN 182 98. .137 30, .569 42, .092 1. .00 38. .62 1SG1373
ATOM 1373 CD GLN 182 97. .494 30, .829 43, .446 1. .00 38. .62 1SG1374
ATOM 1374 OEl GLN 182 96. .604 30. .098 43 .876 1. .00 38. .62 1SG1375
ATOM 1375 NE2 GLN 182 97 .965 31 .898 44 .142 1. .00 38, .62 1SG1376
ATOM 1376 C GLN 182 97. .488 27, .562 39, .794 1. .00 38. .62 1SG1377
ATOM 1377 0 GLN 182 97. .979 26, .504 40, .181 1. .00 38. .62 1SG1378
ATOM 1378 N MET 183 96. .346 27, .608 39, .073 1. .00 41. .02 1SG1379
ATOM 1379 CA MET 183 95. .614 26 .409 38 .750 1. .00 41, .02 1SG1380
ATOM 1380 CB MET 183 94, .207 26 .716 38, .204 1, .00 41, .02 1SG1381
ATOM 1381 CG MET 183 93. .256 25, .515 38. .225 1. .00 41. ,02 1SG1382
ATOM 1382 SD MET 183 93. .577 24. .224 36. .986 1. .00 41. .02 1SG1383
ATOM 1383 CE MET 183 92. .583 2 .967 37, .840 1. .00 41. .02 1SG1384 ATOM 1384 C MET 183 96..269 25.,473 37..767 1..00 41.02 1SG1385
ATOM 1385 O MET 183 96. .500 24. .309 38. .088 1. .00 41. ,02 1SG1386
ATOM 1386 N GLY 184 96. .642 25. .939 36. .555 1. ,00 42. ,41 1SG1387
ATOM 1387 CA GLY 184 97. .055 24. .947 35. .596 1. .00 42. ,41 1SG1388
ATOM 1388 C GLY 184 98. .320 25, .330 34. .905 1. .00 42. ,41 1SG1389
ATOM 1389 O GLY 184 98. ,836 26. .434 35. ,071 1. .00 42. ,41 1SG1390
ATOM 1390 N THR 185 98. ,851 24. .374 34. .110 1. .00 44. ,85 1SG1391
ATOM 1391 CA THR 185 100. ,053 24. .558 33. .354 1. .00 44. ,85 1SG1392
ATOM 1392 CB THR 185 101. .267 23. .975 34. .013 1. .00 44. .85 1SG1393
ATOM 1393 OGl THR 185 101. .139 22. .565 34. .117 1. .00 44. ,85 1SG1394
ATOM 1394 CG2 THR 185 101. .410 24. .596 35. .412 1. .00 44. ,85 1SG1395
ATOM 1395 C THR 185 99. .871 23. .825 32. .063 1. .00 44. .85 1SG1396
ATOM 1396 O THR 185 98. .896 23, .097 31, .878 1. .00 44. .85 1SG1397
ATOM 1397 N VAL 186 100. .816 24, .017 31, .121 1. .00 46. .98 1SG1398
ATOM 1398 CA VAL 186 100. .728 23, .348 29, .858 1. .00 46. .98 1SG1399
ATOM 1399 CB VAL 186 100. .562 24, .309 28, .720 1. .00 46. .98 1SG1400
ATOM 1400 CGI VAL 186 101, .762 25, .273 28 .726 1. .00 46, .98 1SG1401
ATOM 1401 CG2 VAL 186 100. .393 23. .514 27, .415 1. .00 46. .98 1SG1402
ATOM 1402 C VAL 186 102. .004 22. .596 29, .653 1. .00 46. .98 1SG1403
ATOM 1403 O VAL 186 103. .084 23, .079 29, .985 1. .00 46, .98 1SG1404
ATOM 1404 N LYS 187 101. .922 21, .368 29, .109 1. .00 48, .58 1SG1405
ATOM 1405 CA LYS 187 103. .155 20, .665 28 .932 1. .00 48, .58 1SG1406
ATOM 1406 CB LYS 187 103. .113 19, .206 29, .415 1. .00 48, .58 1SG1407
ATOM 1407 CG LYS 187 103. .023 19, .096 30 .940 1. .00 48, .58 1SG1408
ATOM 1408 CD LYS 187 102, .688 17, .694 31 .452 1 .00 48, .58 1SG1409
ATOM 1409 CE LYS 187 102, .636 17, .607 32 .979 1 .00 48 .58 1SG1410
ATOM 1410 NZ LYS 187 102, .333 16 .221 33 .398 1 .00 48 .58 1SG1411
ATOM 1411 C LYS 187 103, .515 20 .688 27 .483 1 .00 48 .58 1SG1412
ATOM 1412 O LYS 187 102. .818 20, .109 26, .648 1. .00 48, .58 1SG1413
ATOM 1413 N TYR 188 104. .627 21, .383 27. .149 1. .00 52, .55 1SG1414
ATOM 1414 CA TYR 188 105, .049 21, .414 25, .780 1, .00 52, .55 1SG1415
ATOM 1415 CB TYR 188 105, .501 22, .791 25, .258 1 .00 52, .55 1SG1416
ATOM 1416 CG TYR 188 104, .383 23, .774 25 .274 1 .00 52 .55 1SG1417
ATOM 1417 CDl TYR 188 103. .376 23, .708 24 .343 1 .00 52 .55 1SG1418
ATOM 1418 CD2 TYR 188 104, .331 24 .756 26 .231 1 .00 52 .55 1SG1419
ATOM 1419 CE1 TYR 188 102, .345 24 .616 24 .349 1 .00 52 .55 1SG1420
ATOM 1420 CE2 TYR 188 103, .304 25 .669 26 .243 1 .00 52 .55 1SG1421
ATOM 1421 CZ TYR 188 102, .310 25 .602 25 .300 1 .00 52 .55 1SG1422
ATOM 1422 OH TYR 188 101, .253 26 .535 25 .306 1 .00 52 .55 1SG1423
ATOM 1423 C TYR 188 106, .281 20, .576 25, .659 1, .00 52, .55 1SG1424
ATOM 1424 O TYR 188 107, .240 20, .993 25, .013 1, .00 52, .55 1SG1425
ATOM 1425 N VAL 189 106, .271 19. .351 26 .214 1, .00 53, .72 1SG1426
ATOM 1426 CA VAL 189 107. .441 18. .514 26 .162 1, .00 53, .72 1SG1427
ATOM 1427 CB VAL 189 107, .396 17. .360 27 .131 1, .00 53, .72 1SG1428
ATOM 1428 CGI VAL 189 107, .226 17, .899 28 .561 1 .00 53, .72 1SG1429
ATOM 1429 CG2 VAL 189 106, .283 16 .389 26 .702 1 .00 53, .72 1SG1430
ATOM 1430 C VAL 189 107, .522 17 .901 24 .797 1 .00 53 .72 1SG1431
ATOM 1431 O VAL 189 106, .500 17 .539 24 .217 1 .00 53 .72 1SG1432
ATOM 1432 N LEU 190 108, .748 17 .773 24 .241 1 .00 51 .81 1SG1433
ATOM 1433 CA LEU 190 108, .899 17 .158 22 .951 1 .00 51 .81 1SG1434
ATOM 1434 CB LEU 190 110, .287 17 .343 22 .310 1 .00 51 .81 1SG1435
ATOM 1435 CG LEU 190 110, .608 18, .789 21 .893 1, .00 51, .81 1SG1436
ATOM 1436 CD2 LEU 190 111, .854 18, .843 20 .994 1 .00 51, .81 1SG1437
ATOM 1437 CDl LEU 190 110, .709 19, .719 23 .113 1 .00 51, .81 1SG1438
ATOM 1438 C LEU 190 108, .678 15 .686 23 .101 1 .00 51, .81 1SG1439
ATOM 1439 O LEU 190 109, .270 15 .037 2 .962 1, .00 51, .81 1SG1440
ATOM 1440 N MET 191 107. .754 15 .150 22 .279 1 .00 48 .99 1SG1441 > >>>> >>>> > >>> >> > > > > > >
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH OOOOOOOOOOOPPPPOOOOPPPPPPPPOOOOOPPPOPPPPOOOPOPPPPOPOOQOPQ 332222222222223222222222333333333333333333333333322222333
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H 4* 4* 4* 4* 4* 4* 4* ιt* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* ι^ ι^ 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* iD vo iD VD Vo vo vD VD θo cD CD ∞ _3 oo cD eD CD θθ si si si si sj si si sj si ^ en en m σι σ cn cn cn m en ιn uι uι uι ιn uι ιn ιn uι 4* 4* 4* 4* 4* si en 4* UJ M H θ vo oo si cn ιn 4* u tθ H θ vo oo s σι ιn 4* UJ tθ H o vD θθ si σι ui 4* UJ tθ H θ o oo si en ui 4* uι tθ H θ vo oo si tn ui 4* uJ t H
3 P Ω P Ω Ω a P Ω Ω Ω 3 P Ω Ω P Ω Ω 3 0 Ω Ω O Ω Ω P Ω Ω Ω 3 P Ω Ω Ω Ω Ω 3 O Ω Ω Ω 3 P Ω P Ω Ω a P Ω Ω to Ω Ω Ω
Ώ ro > ro > Ω Ω ω Ω Ω ro > Ω ω d > ro > Ω ro > M d Ω ω > to H to H a >
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Ω Ω Ώ Ω Ω Ώ Ω Ω Ώ Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω
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4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 1^ 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* ι^ VD VD VD VD VD vo vD VD θo oo ∞ cD ∞ ω cD CD CD CD si si si si si si si si si si en cn cn en cn m cn σ m cn ιn uι uι uι ιn uι uι uι uι uι 4* 4* 4* 4* ιt* 4* 4* 4*
CD sl Cn U1 4* -J tO H O VD 00 sl _l _1 4* Ul t H O V0 00 sl 01 U1 4* Ul tO o iD Oo -j en ui 4* ui tO H O iD OO si en ui 4* UJ tO H O vo oo si oi ui 4* ui to
ATOM 1498 CB TYR 200 108.,808 22..113 7.,561 1.00 58.33 1SG1499
ATOM 1499 CG TYR 200 108. .260 20. .736 7. .384 1. 00 58. ,33 1SG1500
ATOM 1500 CDl TYR 200 107. .751 20. .349 6. ,165 1. 00 58. 33 1SG1501
ATOM 1501 CD2 TYR 200 108. .273 19. .827 8. ,417 1. 00 58. 33 1SG1502
ATOM 1502 CE1 TYR 200 107, .243 19. .084 5. .988 1. ,00 58. ,33 1SG1503
ATOM 1503 CE2 TYR 200 107. .766 18. .561 8. ,248 1. ,00 58. ,33 1SG1504
ATOM 1504 CZ TYR 200 107. .244 18. .191 7. ,032 1. 00 58. ,33 1SG1505
ATOM 1505 OH TYR 200 106. .721 16, .893 6. .852 1. ,00 58. .33 1SG1506
ATOM 1506 C TYR 200 110. .946 21, .206 8. .203 1. .00 58. .33 1SG1507
ATOM 1507 O TYR 200 111. .297 20. .043 7. .994 1. ,00 58. ,33 1SG1508
ATOM 1508 N ILE 201 Ill, .107 21. .830 9. .395 1. .00 54. .81 1SG1509
ATOM 1509 CA ILE 201 111. .643 21. .142 10. .534 1. .00 54. .81 1SG1510
ATOM 1510 CB ILE 201 112. .553 21, .974 11. .392 1. .00 54. .81 1SG1511
ATOM 1511 CG2 ILE 201 112, .977 21. .108 12. .590 1. .00 54. .81 1SG1512
ATOM 1512 CGI ILE 201 113, .737 22. .515 10. .579 1. ,00 54. .81 1SG1513
ATOM 1513 CDl ILE 201 113, .320 23. .582 9, .571 1. .00 54. .81 1SG1514
ATOM 1514 C ILE 201 110, .443 20, .875 11. .382 1. .00 54. .81 1SG1515
ATOM 1515 O ILE 201 109, .726 21, .797 11. .763 1. ,00 54. .81 1SG1516
ATOM 1516 N GLN 202 110 .169 19, .601 11, .690 1. .00 50. .04 1SG1517
ATOM 1517 CA GLN 202 108, .977 19, .325 12, .434 1. .00 50. .04 1SG1518
ATOM 1518 CB GLN 202 108, .216 18, .089 11, .926 1. .00 50. .04 1SG1519
ATOM 1519 CG GLN 202 106 .942 17 .804 12, .721 1. .00 50. .04 1SG1520
ATOM 1520 CD GLN 202 106 .285 16, .563 12, .136 1. .00 50. .04 1SG1521
ATOM 1521 OEl GLN 202 105, .263 16, .095 12. .635 1. .00 50. .04 1SG1522
ATOM 1522 NE2 GLN 202 106 .883 16 .017 11. .044 1. .00 50. .04 1SG1523
ATOM 1523 C GLN 202 109 .323 19, .072 13, .863 1. .00 50. .04 1SG1524
ATOM 1524 O GLN 202 110 .237 18, .305 14. .167 1. .00 50. .04 1SG1525
ATOM 1525 N LEU 203 108 .594 19, .733 14, .788 1. .00 46. .35 1SG1526
ATOM 1526 CA LEU 203 108 .806 19, .531 16, .195 1. .00 46, .35 1SG1527
ATOM 1527 CB LEU 203 109 .212 20 .813 16 .942 1. .00 46 .35 1SG1528
ATOM 1528 CG LEU 203 110 .544 21 .404 16, .450 1. .00 46, .35 1SG1529
ATOM 1529 CD2 LEU 203 111 .656 20, .345 16, .450 1. .00 46, .35 1SG1530
ATOM 1530 CDl LEU 203 110 .915 22 .673 17 .232 1. .00 46 .35 1SG1531
ATOM 1531 C LEU 203 107 .504 19 .074 16. .777 1. .00 46, .35 1SG1532
ATOM 1532 O LEU 203 106 .485 19, .749 16, .637 1. .00 46, .35 1SG1533
ATOM 1533 N ASP 204 107 .514 17 .906 17 .454 1, .00 46, .51 1SG1534
ATOM 1534 CA ASP 204 106 .310 17 .368 18. .019 1. .00 46, .51 1SG1535
ATOM 1535 CB ASP 204 106 .176 15. .846 17, .834 1. .00 46. .51 1SG1536
ATOM 1536 CG ASP 204 106 .052 15 .561 16 .344 1. .00 46. .51 1SG1537
ATOM 1537 ODl ASP 204 106 .337 16 .492 15 .545 1. .00 46, .51 1SG1538
ATOM 1538 OD2 ASP 204 105 .683 14, .411 15, .984 1. .00 46, .51 1SG1539
ATOM 1539 C ASP 204 106 .333 17 .622 19 .491 1, .00 46, .51 1SG1540
ATOM 1540 O ASP 204 107 .308 17 .317 20, .176 1. .00 46, .51 1SG1541
ATOM 1541 N PHE 205 105 .238 18. .202 20, .015 1. .00 50, .31 1SG1542
ATOM 1542 CA PHE 205 105 .164 18 .478 21 .415 1. .00 50, .31 1SG1543
ATOM 1543 CB PHE 205 105 .037 19 . 911 21, .737 1. .00 50, .31 1SG1544
ATOM 1544 CG PHE 205 106 .284 20 .641 21 .259 1. .00 50, .31 1SG1545
ATOM 1545 CDl PHE 205 106 .414 21 .006 19 .938 1. .00 50, .31 1SG1546
ATOM 1546 CD2 PHE 205 107 .321 20 .900 22, .126 1, .00 50, .31 1SG1547
ATOM 1547 CE1 PHE 205 107 .559 21 .620 19 .489 1. .00 50 .31 1SG1548
ATOM 1548 CE2 PHE 205 108 .470 21 .513 21 .683 1, .00 50, .31 1SG1549
ATOM 1549 CZ PHE 205 108 .591 21, .873 20, .362 1. .00 50. .31 1SG1550
ATOM 1550 C PHE 205 103 .941 17 .797 21 .928 1, .00 50. .31 1SG1551
ATOM 1551 O PHE 205 103 .038 17 .436 21, .176 1, .00 50, .31 1SG1552
ATOM 1552 N SER 206 103 .877 17, .622 23, .260 1. .00 55, .94 1SG1553
ATOM 1553 CA SER 206 102 .761 17 .001 23 .913 1. .00 55, .94 1SG1554
ATOM 1554 CB SER 206 103 .112 16 .531 25, .336 1. .00 55, .94 1SG1555 ATOM 1555 OG SER 206 103..434 17,.646 26..153 1..00 55..94 1SG1556
ATOM 1556 C SER 206 101. .531 17, .881 24. .037 1. .00 55. .94 1SG1557
ATOM 1557 O SER 206 100. .451 17, .293 24. .043 1. .00 55. .94 1SG1558
ATOM 1558 N PRO 207 101. .558 19, .211 24. .002 1, .00 58. .74 1SG1559
ATOM 1559 CA PRO 207 100, .517 20, .014 24, .581 1. .00 58. .74 1SG1560
ATOM 1560 CD PRO 207 102, .230 19, .985 22, .967 1, .00 58. .74 1SG1561
ATOM 1561 CB PRO 207 100, .393 21 .298 23, .765 1. .00 58, .74 1SG1562
ATOM 1562 CG PRO 207 101, .773 21 .437 23, .130 1. .00 58, .74 1SG1563
ATOM 1563 C PRO 207 99 .200 19 .508 25, .036 1, .00 58, .74 1SG1564
ATOM 1564 O PRO 207 98 .269 19 .264 24, .269 1, .00 58, .74 1SG1565
ATOM 1565 N VAL 208 99 .148 19 .422 26, .375 1 .00 53. .61 1SG1566
ATOM 1566 CA VAL 208 97 .995 19 .083 27 .131 1, .00 53. .61 1SG1567
ATOM 1567 CB VAL 208 97 .958 17 .643 27, .547 1, .00 53, .61 1SG1568
ATOM 1568 CGI VAL 208 96 .732 17 .422 28 .448 1, .00 53, .61 1SG1569
ATOM 1569 CG2 VAL 208 97 .977 16 .772 26, .279 1 .00 53, .61 1SG1570
ATOM 1570 C VAL 208 98 .110 19 .901 28 .373 1 .00 53, .61 1SG1571
ATOM 1571 O VAL 208 99 .191 20 .021 28 .950 1 .00 53, .61 1SG1572
ATOM 1572 N VAL 209 96 .994 20 .503 28 .814 1 .00 47, .64 1SG1573
ATOM 1573 CA VAL 209 97 .048 21 .262 30 .023 1 .00 47 .64 1SG1574
ATOM 1574 CB VAL 209 95 .868 22 .168 30 .224 1 .00 47 .64 1SG1575
ATOM 1575 CGI VAL 209 96 .013 22 .862 31 .588 1 .00 47 .64 1SG1576
ATOM 1576 CG2 VAL 209 95 .791 23 .143 29 .038 1 .00 47 .64 1SG1577
ATOM 1577 C VAL 209 97. .037 20, .253 31, .117 1, .00 47, .64 1SG1578
ATOM 1578 O VAL 209 96. .406 19, .205 30, .989 1, .00 47, .64 1SG1579
ATOM 1579 N GLN 210 97. .773 20. .532 32, .208 1, .00 41. .65 1SG1580
ATOM 1580 CA GLN 210 97. .820 19, .623 33. .315 1, .00 41. .65 1SG1581
ATOM 1581 CB GLN 210 99, .210 19, .008 33. .558 1, .00 41. .65 1SG1582
ATOM 1582 CG GLN 210 99 .639 17. .984 32 .505 1, .00 41. .65 1SG1583
ATOM 1583 CD GLN 210 98, .894 16 .684 32. .782 1, .00 41. .65 1SG1584
ATOM 1584 OEl GLN 210 99 .270 15 .621 32. .288 1, .00 41, .65 1SG1585
ATOM 1585 NE2 GLN 210 97 .810 16 .767 33 .599 1, .00 41, .65 1SG1586
ATOM 1586 C GLN 210 97, .469 20, .392 34. .547 1, .00 41, .65 1SG1587
ATOM 1587 O GLN 210 97 .484 21 .622 34. .550 1, .00 41, .65 1SG1588
ATOM 1588 N GLN 211 97 .112 19 .672 35. .630 1, .00 35, .63 1SG1589
ATOM 1589 CA GLN 211 96, .787 20 .322 36. .868 1, .00 35. .63 1SG1590
ATOM 1590 CB GLN 211 95 .360 20 .038 37. .364 1, .00 35, .63 1SG1591
ATOM 1591 CG GLN 211 95 .028 20 .740 38. .682 1, .00 35, .63 1SG1592
ATOM 1592 CD GLN 211 93 .608 20 .361 39. .075 1, .00 35, .63 1SG1593
ATOM 1593 OEl GLN 211 93 .018 19 .438 38. .514 1, .00 35, .63 1SG1594
ATOM 1594 NE2 GLN 211 93 .043 21, .088 40. .075 1, .00 35, .63 1SG1595
ATOM 1595 C GLN 211 97 .722 19 .790 37, .908 1, .00 35, .63 1SG1596
ATOM 1596 O GLN 211 97 .934 18 .585 38 .011 1, .00 35, .63 1SG1597
ATOM 1597 N GLN 212 98 .339 20 .704 38, .679 1, .00 34, .61 1SG1598
ATOM 1598 CA GLN 212 99 .261 20 .356 39, .722 1, .00 34 , .61 1SG1599
ATOM 1599 CB GLN 212 100 .027 21, .588 40, .232 1, .00 34 , .61 1SG1600
ATOM 1600 CG GLN 212 99. .128 22. .637 40. .891 1. .00 34. .61 1SG1601
ATOM 1601 CD GLN 212 99. .995 23. .826 41. .278 1. .00 34. .61 1SG1602
ATOM 1602 OEl GLN 212 99. .573 24. .705 42. .029 1. .00 34. ,61 1SG1603
ATOM 1603 NE2 GLN 212 101. .246 23. .860 40. .745 1. .00 34. ,61 1SG1604
ATOM 1604 C GLN 212 98. .546 19. .738 40. .888 1. .00 34. .61 1SG1605
ATOM 1605 O GLN 212 99. .025 18. .767 41. .473 1. .00 34. .61 1SG1606
ATOM 1606 N LYS 213 97. .375 20. .291 41. .263 1. .00 33. ,13 1SG1607
ATOM 1607 CA LYS 213 96. .697 19. .828 42. .441 1. ,00 33. .13 1SG1608
ATOM 1608 CB LYS 213 95. .429 20. .639 42. .765 1. ,00 33. .13 1SG1609
ATOM 1609 CG LYS 213 95. .727 22. .032 43. .329 1. ,00 33. ,13 1SG1610
ATOM 1610 CD LYS 213 96. .361 22. .995 42. .323 1. ,00 33. ,13 1SG1611
ATOM 1611 CE LYS 213 96. .698 24. .365 42. .919 1. ,00 33. ,13 1SG1612 ATOM 1612 NZ LYS 213 95..465 25.,033 43..392 1.,00 33..13 1SG1613
ATOM 1613 C LYS 213 96. ,317 18. ,393 42. .293 1. ,00 33. .13 1SG1614
ATOM 1614 O LYS 213 96. ,573 17. .589 43. .189 1. .00 33. .13 1SG1615
ATOM 1615 N GLY 214 95. .711 18. .018 41, .153 1. .00 32. .48 1SG1616
ATOM 1616 CA GLY 214 95. .333 16. .646 40. .985 1. .00 32. .48 1SG1617
ATOM 1617 C GLY 214 95. .506 16. .323 39. .543 1. .00 32. .48 1SG1618
ATOM 1618 O GLY 214 95. ,262 17. ,162 38. .678 1. ,00 32. .48 1SG1619
ATOM 1619 N LYS 215 95, .922 15. .080 39, .240 1. .00 37. .09 1SG1620
ATOM 1620 CA LYS 215 96. .139 14. .758 37. .865 1. .00 37. .09 1SG1621
ATOM 1621 CB LYS 215 97. .411 13. .932 37. .620 1. .00 37. .09 1SG1622
ATOM 1622 CG LYS 215 98. .678 14. .585 38. .179 1. .00 37. .09 1SG1623
ATOM 1623 CD LYS 215 98. .900 16. .029 37, .723 1. .00 37. .09 1SG1624
ATOM 1624 CE LYS 215 98. .894 16. .217 36, .206 1. .00 37, .09 1SG1625
ATOM 1625 NZ LYS 215 00. .031 15. .492 35, .599 1. .00 37, .09 1SG1626
ATOM 1626 C LYS 215 94. .984 13. .937 37. .407 1. .00 37, .09 1SG1627
ATOM 1627 O LYS 215 94. .589 12. .975 38. .066 1. .00 37, .09 1SG1628
ATOM 1628 N THR 216 94. .398 14. .314 36. .256 1. .00 41, .75 1SG1629
ATOM 1629 CA THR 216 93, .300 13. .564 35. .733 1, .00 41, .75 1SG1630
ATOM 1630 CB THR 216 92, .000 14. .313 35. .694 1. .00 41, .75 1SG1631
ATOM 1631 OGl THR 216 91, .633 14. .729 37 .001 1 .00 41 .75 1SG1632
ATOM 1632 CG2 THR 216 90. .919 13, .383 35 .114 1, .00 41 .75 1SG1633
ATOM 1633 C THR 216 93. .642 13. .214 34, .328 1 .00 41 .75 1SG1634
ATOM 1634 O THR 216 94. .358 13. .944 33, .642 1, .00 41, .75 1SG1635
ATOM 1635 N ILE 217 93 .117 12. .063 33 .877 1 .00 48 .93 1SG1636
ATOM 1636 CA ILE 217 93 .382 11. .561 32 .566 1 .00 48 .93 1SG1637
ATOM 1637 CB ILE 217 92. .801 10. .200 32 .320 1 .00 48 .93 1SG1638
ATOM 1638 CG2 ILE 217 93. .453 9, .209 33 .298 1, .00 48, .93 1SG1639
ATOM 1639 CGI ILE 217 91, .266 10. .255 32. .417 1, .00 48, .93 1SG1640
ATOM 1640 CDl ILE 217 90 .574 9 .004 31 .880 1 .00 48 .93 1SG1641
ATOM 1641 C ILE 217 92 .761 12, .475 31 .580 1 .00 48 .93 1SG1642
ATOM 1642 O ILE 217 91, .650 12, .970 31 .763 1, .00 48 .93 1SG1643
ATOM 1643 N LYS 218 93, .507 12. .704 30 .492 1, .00 55, .34 1SG1644
ATOM 1644 CA LYS 218 93 .114 13 .568 29 .437 1 .00 55 .34 1SG1645
ATOM 1645 CB LYS 218 94 .123 13, .558 28 .278 1 .00 55 .34 1SG1646
ATOM 1646 CG LYS 218 95, .508 14, .066 28 .682 1 .00 55 .34 1SG1647
ATOM 1647 CD LYS 218 96, .627 13, .605 27. .747 1, .00 55 .34 1SG1648
ATOM 1648 CE LYS 218 96 .547 14 .183 26 .335 1 .00 55 .34 1SG1649
ATOM 1649 NZ LYS 218 97 .671 13 .665 25 .522 1 .00 55 .34 1SG1650
ATOM 1650 C LYS 218 91, .829 13. .083 28 .903 1, .00 55 .34 1SG1651
ATOM 1651 O LYS 218 91. .396 11. .964 29 .187 1, .00 55, .34 1SG1652
ATOM 1652 N LEU 219 91 .197 13 .956 28 .100 1 .00 56 .14 1SG1653
ATOM 1653 CA LEU 219 89 .960 13 .631 27 .480 1 .00 56, .14 1SG1654
ATOM 1654 CB LEU 219 89 .459 14. .743 26 .530 1, .00 56, .14 1SG1655
ATOM 1655 CG LEU 219 88. .088 14. .505 25. .862 1, .00 56, .14 1SG1656
ATOM 1656 CD2 LEU 219 87 .016 14 .166 26 .909 1 .00 56 .14 1SG1657
ATOM 1657 CDl LEU 219 88 .165 13 .473 24 .726 1 .00 56, .14 1SG1658
ATOM 1658 C LEU 219 90 .269 12. .387 26 .731 1, .00 56, .14 1SG1659
ATOM 1659 O LEU 219 91. .417 12. .126 26 .374 1, .00 56, .14 1SG1660
ATOM 1660 N ALA 220 89 .236 11 .569 26 .504 1 .00 55, .47 1SG1661
ATOM 1661 CA ALA 220 89 .432 10 .269 25 .954 1 .00 55, .47 1SG1662
ATOM 1662 CB ALA 220 88 .107 9, .542 25 .666 1 .00 55, .47 1SG1663
ATOM 1663 C ALA 220 90, .184 10, .380 24. .669 1, .00 55, .47 1SG1664
ATOM 1664 O ALA 220 91 .037 9 .543 24 .379 1 .00 55, .47 1SG1665
ATOM 1665 N ASP 221 89 .910 11 .419 23 .865 1 .00 51, .74 1SG1666
ATOM 1666 CA ASP 221 90, .608 11, .526 22 .617 1. .00 51, .74 1SG1667
ATOM 1667 CB ASP 221 90, .219 12, .772 21, .806 1. .00 51. .74 1SG1668
ATOM 1668 CG ASP 221 88 .764 12 .637 21 .384 1, .00 51. .74 1SG1669 > > >>>>>>>>>>>>> > >>>>> >> >> > >>>> >> > > >> >> HHHHHHHHH HHHHHHH HHHHHHHH HHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHH O OP P P P P OO P O OPP PO P PPOO PPP PP P PO P P P P P P P P OPP PPPP OOP PP PPOOO OQO 333322222222222222333333333333333333222222222233333333323
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H si si si si s si si si si si si si s) si s] si si s] -J si si si σi cn en σ on on on cn cn cn cn cn cn cn en cn oi on cn σi cn cn cn en cn cn on cn cn cn cn to to to to to to H H H H H H O O O O O O VD VD VO VD VD VD VO VD VD VD OO OO OO OO OO CO OO OO CD OO sJ sl sl sl sl sl sl sl sJ sl on
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Ω ΩΩ 3 P Ω ΩΩ Ω Ω Ω ΩΩ Ω 3 P Ω Ω P Ω Ω 3 P Ω Ω Ω Ω Ω Ω 3 Ω Ω Ω 3 P Ω O O Ω Ω Ω Ω 3 O Ω Ω a Ω Ω Ω 3 P Ω O P ro d MM Ωro C10 B > d d Ω ro ω > M M d Ω ω > to H to H IO H H to to H > ω ; O d to H
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H H H H H H H H
VO VD O VD O VO O O O O O O VD VD VD VD VO VO VD VD VD VD VD VD VD VD VO VD VD VD VD VD VO VD IO VD VD VO VO VO VO VO VO ID VD VD VD VD VO IO VO VO VO VD VO OO OO vD sj o vD θ VD t H to o H θ ∞ CD VD si ω ιo vD CD e» CD vo oo uι cn m si s] si cn si si si <n en ui H H H to uJ 4* 4* 4* 4* 4* 4* uι 4* _i ι to to to oo oo
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H H H H H H H H H H H tO tO tO t to to to to to to uJ Ui 4* uι en oι o o vo o co vo oo s] si si si on co si ω iD H θ t0 4* UI IO tO tO H tO tO UI 4* Ul uι cn 4* uι uι uι σi s] sj oo vD θ tθ H H tO tO Ul t O H to o to w H to uι iD W to en o uι uj oo 4* vD uι to uι ui si H VD C)n <n σι oo o CD iθ si ιt* 4* tθ sj uJ uι uJ Ui oo to o ιt* VD Ui si 4* to en ιt* t H θo θ3 θo on Cn θ CsJ tO H t0 00 4* -J UJ VO UJ H VO -l UI VO O l0 00 4* lD OO ιt* 00 _J sl OO Ul sl H VD VO UJ H H -l CD θn θ s] t O lo to σi si oo si cn tO H to oo H UJ
VD to to oo oo to to oo _J 4* uι o _ι 4* oo oo 4» vo o vD VD θo o o cn o o uι σi H θo ui H oo en vo o uι uι o o θ si 4* tO IO Ul UJ sl H in 4* 0 4* sl 4* 0 H H H H H H H H H H H H H H H o o o o o o oo o o o oo o o o o o o o o oo o o o oo o oo ooo oo o o o oo o o o oo oo o o o o o o oo o o o o o o o o o o oo o o o oo o oo o o o oo o o oo o oo o oσ o o o oo o o oo o oo ooo o o oo o o oo
4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 1^ 4* 4* 4*
W M W to to to to to to to to to to to to o o o o o o o iD io vo to to to to oi cn σi σi σi H H H H
H H H H to to to to to to to to to to to ui ui ui ui ui ui ui σi cn σi cn σi σi cn cn
H H H H H H H H H H H H H H H H H H H H to to to to to to to to to to to to to w m w to to to to to m to to to to to to to to w w to to to to to to to to to to to to to to to to to to to to W to CD to to
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-0 si si si -J si sl sl sl sl ssl] sJ -J - sJi - sOj sl sl sl sJ sl si si J si s si ssii ssji oσi ocn oσi ocni oσi σσii oσii oσi cσrii oσi σσii ccJn ocni σcni σeni ocn σeni σσii oσii ooii σσi oσi oσii σσi oσi oσi oσi oσ ooi oi to to to to to t H H H H o O _ O O VO VD VD VO VD VD VD VD VO VO CD OO CO σO OO OO OO OO OO CO sl sl sl sl sl sl sJ sl sl sl σi ui 4* ui to VD 00 on ui J t H O VO 00 on ui UJ t -o' ■■ o vo oo si en ui 4* uj to H o io oo • — ■- - ■■ .• ■■ — ■- — . _. ._ _ .. .. H.. O—
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P P O O P P P O P P P O O P P P O P O P P O P P P O P P O P P P P P O O P P P P P P P P P O P P O P P O O P P P P
3 2 2 2 2 3 3 3 3 3 2 3 2 2 2 2 2 2 2 2 2 3 22 22 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
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Ω P Ω Ω a P Ω P Ω Ω P Ω Ω a p Ω 3 Ω Ω Ω Ω Ω a p Ω Ω Ω 3 P Ω P Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω 3 Ω Ω n Ω 3 o Ω Ω
Ω ro > Ω ω > tsl M d Ω ro > « > a tsi M M d d Ω td a O Ω O Ω t H to H > > M M d Ω to ω H > Ω to W to to to to to to to to to Ω Ω Ω CH C C CH trl CH C-| CH CH > > H H H H H H H H H H H H Ω Ω Ω Ω C- Ω C- Ω Ω Ω Ω G- 6- ,ϋ O O M M M M M M M M M M M C tH CH H Kj H. Kj Kj Kl Kj is is K; . _ P P ^ Kj is is r C C P C C f P P r C C f ϋf W ϋ)
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H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H o o o o o o o o o o o o o o o o o o o o _ o_ o_ o_ o_ o_ o o oo o o oo o oo o oo o o oo o oo o o o oo oo o oo uι uJ UJ UJ ιt* 4* ui -! s] cn si co oo co s] s] cn to tO UI 4* Ul Ul Ul Ul UJ 4* Ul s] 01 0n sl sl sl C0 sl sl 00 sl Ul Ul U1 4* 4* Ul UJ UI UJ 4* U1 4* ω t H H to 01 O 4* 00 4* t to O si o on H _ι uι o oo cn co oo σι en s] to vo ι^ uj oo uj ι& _ι vo to ro o H uι vo to o vo oo 4* ιo H 4* s] 4* oo o to vD -J uι to uι oo Ul 4* Ul VD 00 00 si Ol IO » V0 H O O tO 00 H UJ sl H CD UJ UJ VO -l tO Ul 00 tO sl tO UJ 01 H 4* 4* 00 t0 00 H t0 l0 O UJ Ui en sl 4* sJ lD tO 00 t0 H O UI 00 o vo on co on oo oo oo to in H tO sl H tO ln lD VD UJ -l lD VD 01 Ul Ul tO O tO t0 4* Ul tO sl 4* l0 4* O VD sl CO UJ tO Ul H 00 01 0 sl sl lD UI VO H VD 4* UJ H lO I IO W W W W W W U U W U U U U W U U U W U U U U W W - U U U W U U NJ W W W U U W W W W W KJ IO tO tO W W IO tO W W IO W en in cn si si iD co o vD VD O vo o H to o H en in 4* 4* to j tO i uj to H H o o vo o cD o oo io vD vo oci si si en ui it* 4* H O H to to ui to 4* uJ UJ
4* UJ 01 UJ Oi aj lO tO tO t0 4* tO UJ ln W CD C» 4* SJ O O OO sl tO H O Ul UJ 0 01 sl tO lO VO sl 01 4* 4* H J ln W Ul <D 01 4* 4* s] H tO H 4* tO U1 0 0 .0 ω ω H 4* vo oo sι ιn cD UJ UJ σi ιt* VD θn to vD cn uJ UJ to tj e» si o o H θo to H ιf* cn cD m uj vo on 4* 4* o to o si H H Ui si o oo oo on uι ui si ui 4* o ω to vo si en H 4* tθ H o ιo uJ uι uι ijJ vo ιn to 4* o to m cD iD ιt* si ω oo o ι 4* σi H 4* 4* w w o M in 4* uι W si to to tθ H H tθ ιt* oo H Co
H H H H H uι σ o to to H H 4* UJ H H O O V0 lD sl 00 01 sl sl 00 00 sl cn ui Ul 4* UJ UJ Ul UJ t H O O O O H t0 W UJ Ul 4* UJ 4* tO UJ H tO tO t 4* 4* 4* U1 4* 4* tθ s] si o o m ao H 4* ιo to σ uJ si H ui H VD to ω ιn -4 cn ω io o vD vo ui si ιn H uι σι vo σi 4* CD si tθ H θ Ui uJ in si to oo tθ si to ui H UJ σι o o θ si uι ra to e» UJ si si σι ιo ∞ H si si j 4* ιn ω _3 o w ιn H to W si ιo oo uJ o σi si 4* UJ cn σi si to uj uι 4* UJ θ H θ 4* H UJ s] σι uι ιo o H H CD H θ 4* ω si ιn to cn co cn ui H θo uι uJ si 4* uj ui sj H H cn uJ iD in vD uι w ui si en ιn si tθ H θ 4* iD vo oo tθ H en σi si en H θθ H to o ιn o ιo uj
H H H H H o oo o o o o o o o o o o o o o o o o o o oo o oo o oo o o o o o o o ooo o o o oooo oo o o o o o oo o o o o o o oo o o o o o o oo oo o o o oo ooo o o o oo oo o oo oo o oo oo ooo oo o o o o o oo o oo o
4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 1^ 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 1^ 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* UJ UJ UJ UJ Ul H H H H H H H H H H H H H H H H H H H O O O O O O O O O O O O O O O O O O O O O H H H H H H H H H tO tO tO
H H H H H Ui ui ui -i -i m H H H H Oi cn cn σi σi σi σi σi σi H H H H H Ui ui ui ui ui ui ui ui ui ui ui ui si sl sl sl H H H H H H H H H Ul Ul Ul
CD ∞ ∞ CD OO CD OD CD σj OO OO lO VO VD lO UI UJ UJ UI Ul UJ UJ UJ UI Ul Ul Ul Ul Ul tO tO tO tO tO tO CO tO tO tO tO tO Ul UI UI UI OO OO OD CO CO OO OO OO OO H H H
H H H H H H H H H H H H H H H H H H H H H H H H H H to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to W to to to to to to to to to m to to to CD to to to to to to to to to
Ω Ω Ω Ω Ώ Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ώ Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H sl sl sl sl sl sl sl sl sl sl si si si si si -J si si si si si -J si oo cD CD ∞ si s] s] si si si sj s] si si σι σi -i σι σι σι m σι σι σι uι ιn uι ι^ ιn ιn _ι uι uι ui 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* ω ω w uJ to H o vo oo si m ui 4* uJ tθ H θ vo oθ s] en ιn ιf> uι tθ H θ io CD sj σι ιn 4* ω J H θ vo oo si σι 4* w co H θ vo oo si σι ui 4* uι to H θ io oc) si
ATOM 1783 O SER 237 104,.015 25..537 13,.515 1..00 43,.18 1SG1784
ATOM 1784 N GLN 238 102, .087 26. .649 13, .885 1. .00 44, .69 1SG1785
ATOM 1785 CA GLN 238 101, .758 25. .848 15. .024 1. .00 44, .69 1SG1786
ATOM 1786 CB GLN 238 101. .562 26. .684 16. .297 1. .00 44, .69 1SG1787
ATOM 1787 CG GLN 238 102. .799 27, .482 16, .709 1. .00 44, .69 1SG1788
ATOM 1788 CD GLN 238 102. .399 28, .363 17, .883 1. .00 44, .69 1SG1789
ATOM 1789 OEl GLN 238 103, .180 29, .181 18, .365 1. .00 44, .69 1SG1790
ATOM 1790 NE2 GLN 238 101 .133 28 .198 18 .354 1, .00 44 .69 1SG1791
ATOM 1791 C GLN 238 100 .446 25 .199 14 .751 1. .00 44 .69 1SG1792
ATOM 1792 O GLN 238 99 .524 25 .823 14 .226 1. .00 44 .69 1SG1793
ATOM 1793 N LEU 239 100 .345 23 .905 15, .099 1. .00 49 .01 1SG1794
ATOM 1794 CA LEU 239 99 .118 23, .189 14, .952 1. .00 49, .01 1SG1795
ATOM 1795 CB LEU 239 99, .305 21, .788 14, .341 1. .00 49, .01 1SG1796
ATOM 1796 CG LEU 239 98, .013 20, .950 14, .228 1. .00 49, .01 1SG1797
ATOM 1797 CD2 LEU 239 96, .916 21, .737 13, .497 1. .00 49, .01 1SG1798
ATOM 1798 CDl LEU 239 97 .537 20 .389 15 .583 1, .00 49 .01 1SG1799
ATOM 1799 C LEU 239 98 .605 23 .005 16 .337 1. .00 49 .01 1SG1800
ATOM 1800 O LEU 239 99, .149 22 .217 17 .110 1. .00 49 .01 1SG1801
ATOM 1801 N LEU 240 97, .520 23, .718 16 .678 1, .00 49 .98 1SG1802
ATOM 1802 CA LEU 240 96, .966 23, .615 17, .992 1, .00 49 .98 1SG1803
ATOM 1803 CB LEU 240 96. .453 24, .977 18, .485 1, .00 49 .98 1SG1804
ATOM 1804 CG LEU 240 97. .544 26, .065 18, .491 1. .00 49 .98 1SG1805
ATOM 1805 CD2 LEU 240 98 .746 25 .658 19 .357 1 .00 49 .98 1SG1806
ATOM 1806 CDl LEU 240 96. .969 27 .426 18 .907 1. .00 49 .98 1SG1807
ATOM 1807 C LEU 240 95. .779 22 .712 17 .871 1. .00 49 .98 1SG1808
ATOM 1808 O LEU 240 94. .734 23 .109 17, .361 1. .00 49 .98 1SG1809
ATOM 1809 N LEU 241 95. .915 21, .467 18, .359 1. .00 48 .98 1SG1810
ATOM 1810 CA LEU 241 94. .887 20, .474 18, .253 1. .00 48, .98 1SG1811
ATOM 1811 CB LEU 241 95. .396 19, .069 18, .613 1. .00 48, .98 1SG1812
ATOM 1812 CG LEU 241 94. .339 17, .959 18, .513 1. .00 48, .98 1SG1813
ATOM 1813 CD2 LEU 241 94. .809 16, .687 19 .229 1. .00 48 .98 1SG1814
ATOM 1814 CDl LEU 241 93. .931 17, .704 17, .056 1, .00 48 .98 1SG1815
ATOM 1815 C LEU 241 93. .782 20, .803 19, .208 1. .00 48 .98 1SG1816
ATOM 1816 O LEU 241 93. .966 21, .520 20, .188 1. .00 48, .98 1SG1817
ATOM 1817 N PRO 242 92. .612 20, .326 18, .883 1. .00 45, .82 1SG1818
ATOM 1818 CA PRO 242 91. .495 20, .495 19, .761 1. .00 45, .82 1SG1819
ATOM 1819 CD PRO 242 92. .185 20, .375 17, .504 1. .00 45, .82 1SG1820
ATOM 1820 CB PRO 242 90. .267 20. .071 18 .964 1. .00 45 .82 1SG1821
ATOM 1821 CG PRO 242 90. .649 20, .465 17, .528 1. .00 45 .82 1SG1822
ATOM 1822 C PRO 242 91. .709 19, .763 21, .038 1. .00 45, .82 1SG1823
ATOM 1823 O PRO 242 91. .098 20. .130 22, .040 1. .00 45, .82 1SG1824
ATOM 1824 N ALA 243 92. .559 18. .722 21, .033 1. .00 39, .25 1SG1825
ATOM 1825 CA ALA 243 92. .813 18. .008 22, .248 1. ,00 39. .25 1SG1826
ATOM 1826 CB ALA 243 93. .797 16. .841 22. .066 1. ,00 39. .25 1SG1827
ATOM 1827 C ALA 243 93. .439 18. .984 23. .185 1. ,00 39. .25 1SG1828
ATOM 1828 O ALA 243 93. .121 19. .014 24, .374 1. .00 39. .25 1SG1829
ATOM 1829 N THR 244 94. .340 19. .830 22, .647 1. .00 35. .04 1SG1830
ATOM 1830 CA THR 244 95. .035 20. .775 23 , .462 1. ,00 35. .04 1SG1831
ATOM 1831 CB THR 244 95. .969 21. .643 22 , .671 1. ,00 35. .04 1SG1832
ATOM 1832 OGl THR 244 96. .934 20. .846 21. .999 1. ,00 35. .04 1SG1833
ATOM 1833 CG2 THR 244 96. .664 22. ,616 23. .638 1. ,00 35. ,04 1SG1834
ATOM 1834 C THR 244 94. 030 21. ,673 24. .111 1. 00 35. ,04 1SG1835
ATOM 1835 O THR 244 94. ,071 21. .883 25, .323 1. .00 35. .04 1SG1836
ATOM 1836 N PHE 245 93. ,085 22. .210 23, .317 1. .00 32. .28 1SG1837
ATOM 1837 CA PHE 245 92. .104 23. .130 23. .827 1. .00 32. .28 1SG1838
ATOM 1838 CB PHE 245 91. 210 23. ,743 22. .736 1. ,00 32. .28 1SG1839
ATOM 1839 CG PHE 245 92. 024 24. ,735 21. ,983 1. 00 32. .28 1SG1840 ATOM 1840 CDl PHE 245 92..208 26..002 22..487 1..00 32..28 1SG1841
ATOM 1841 CD2 PHE 245 92. .598 24, .410 20. .777 1. .00 32. .28 1SG1842
ATOM 1842 CE1 PHE 245 92. .954 26, .932 21. .804 1. .00 32. .28 1SG1843
ATOM 1843 CE2 PHE 245 93. .346 25, .336 20. .089 1. .00 32. .28 1SG1844
ATOM 1844 CZ PHE 245 93. .527 26 .599 20. .601 1. .00 32. .28 1SG1845
ATOM 1845 C PHE 245 91. .198 22 .462 24. .812 1, .00 32. .28 1SG1846
ATOM 1846 O PHE 245 90. .861 23, .047 25. .839 1. .00 32, .28 1SG1847
ATOM 1847 N LEU 246 90. .766 21, .225 24. .516 1, .00 30, .64 1SG1848
ATOM 1848 CA LEU 246 89. .833 20, .516 25. .350 1. .00 30, .64 1SG1849
ATOM 1849 CB LEU 246 89. .388 19 .170 24. .750 1, .00 30 .64 1SG1850
ATOM 1850 CG LEU 246 88. .555 19 .315 23, .461 1, .00 30, .64 1SG1851
ATOM 1851 CD2 LEU 246 87. .372 20, .275 23, .664 1. .00 30, .64 1SG1852
ATOM 1852 CDl LEU 246 88. .119 17, .945 22. .916 1. .00 30. .64 1SG1853
ATOM 1853 C LEU 246 90. .421 20 .234 26. .699 1. .00 30 .64 1SG1854
ATOM 1854 O LEU 246 89, .708 20 .240 27, .701 1. .00 30 .64 1SG1855
ATOM 1855 N SER 247 91. .734 19 .953 26, .767 1. .00 31. .16 1SG1856
ATOM 1856 CA SER 247 92. .336 19, .614 28, .027 1, .00 31, .16 1SG1857
ATOM 1857 CB SER 247 93. .836 19, .288 27. .902 1. .00 31, .16 1SG1858
ATOM 1858 OG SER 247 94. .549 20 .426 27, .440 1. .00 31 .16 1SG1859
ATOM 1859 C SER 247 92. .209 20 .774 28, .962 1. .00 31 .16 1SG1860
ATOM 1860 O SER 247 92. .099 20 .590 30, .173 1. .00 31 .16 1SG1861
ATOM 1861 N ALA 248 92. .237 22 .004 28. .419 1, .00 31 .19 1SG1862
ATOM 1862 CA ALA 248 92. .151 23 .176. 29 .239 1 .00 31 .19 1SG1863
ATOM 1863 CB ALA 248 92, .287 24 .474 28. .426 1 .00 31 .19 1SG1864
ATOM 1864 C ALA 248 90. .822 23 .217 29. .927 1 .00 31 .19 1SG1865
ATOM 1865 O ALA 248 90. .747 23 .502 31, .122 1. .00 31 .19 1SG1866
ATOM 1866 N GLU 249 89. .734 22, .913 29, .192 1. .00 31, .49 1SG1867
ATOM 1867 CA GLU 249 88. .423 22 .994 29 .770 1 .00 31 .49 1SG1868
ATOM 1868 CB GLU 249 87. .283 22 .690 28 .777 1 .00 31 .49 1SG1869
ATOM 1869 CG GLU 249 86, .960 23 .838 27, .815 1. .00 31 .49 1SG1870
ATOM 1870 CD GLU 249 88. .005 23 .846 26, .709 1, .00 31 .49 1SG1871
ATOM 1871 OEl GLU 249 88. .376 22 .737 26 .244 1 .00 31 .49 1SG1872
ATOM 1872 OE2 GLU 249 88, .450 24 .958 26 .318 1 .00 31 .49 1SG1873
ATOM 1873 C GLU 249 88, .308 22 .018 30 .892 1 .00 31 .49 1SG1874
ATOM 1874 O GLU 249 87, .727 22 .328 31, .931 1, .00 31 .49 1SG1875
ATOM 1875 N LEU 250 88. .857 20 .804 30, .709 1, .00 32 .32 1SG1876
ATOM 1876 CA LEU 250 88. .738 19 .796 31 .721 1 .00 32 .32 1SG1877
ATOM 1877 CB LEU 250 89. .353 18 .449 31 .297 1 .00 32 .32 1SG1878
ATOM 1878 CG LEU 250 89. .230 17 .355 32 .376 1, .00 32 .32 1SG1879
ATOM 1879 CD2 LEU 250 90, .053 16, .106 32, .018 1, .00 32, .32 1SG1880
ATOM 1880 CDl LEU 250 87. .757 17. .030 32, .663 1, .00 32, .32 1SG1881
ATOM 1881 C LEU 250 89. .449 20 .237 32 .960 1 .00 32 .32 1SG1882
ATOM 1882 O LEU 250 88. .913 20 .134 34, .063 1, .00 32, .32 1SG1883
ATOM 1883 N ALA 251 90, .685 20, .754 32. .814 1, .00 33, .56 1SG1884
ATOM 1884 CA ALA 251 91, .466 21, .126 33. .958 1, .00 33, .56 1SG1885
ATOM 1885 CB ALA 251 92. .877 21 .614 33. .583 1, .00 33, .56 1SG1886
ATOM 1886 C ALA 251 90. .807 22 .236 34, .716 1, .00 33, .56 1SG1887
ATOM 1887 O ALA 251 90. .749 22, .209 35, .944 1. .00 33, .56 1SG1888
ATOM 1888 N LEU 252 90. .301 23, .254 33. .999 1, .00 38, .23 1SG1889
ATOM 1889 CA LEU 252 89. ,700 24 , .393 34. .633 1, .00 38. .23 1SG1890
ATOM 1890 CB LEU 252 89. .412 25, .540 33. .650 1, .00 38, .23 1SG1891
ATOM 1891 CG LEU 252 90. .694 26, .144 33. .043 1, .00 38, .23 1SG1892
ATOM 1892 CD2 LEU 252 91. .712 26. .516 34. .133 1, .00 38. .23 1SG1893
ATOM 1893 CDl LEU 252 90. .372 27. .321 32. .110 1, .00 38. .23 1SG1894
ATOM 1894 C LEU 252 88. .418 24. .016 35, .305 1, .00 38. .23 1SG1895
ATOM 1895 O LEU 252 88, .101 24, .538 36. .369 1, .00 38, .23 1SG1896
ATOM 1896 N LEU 253 87, .622 23 , .118 34. .699 1, .00 44. .32 1SG1897 ATOM 1897 CA LEU 253 86..355 22..774 35..282 1..00 44..32 1SG1898
ATOM 1898 CB LEU 253 85. .514 21. .854 34. .373 1. .00 44. .32 1SG1899
ATOM 1899 CG LEU 253 84. .106 21. .503 34. .908 1. .00 44. .32 1SG1900
ATOM 1900 CD2 LEU 253 83. .298 22. .776 35. .215 1. .00 44. .32 1SG1901
ATOM 1901 CDl LEU 253 84. .152 20. .529 36. .096 1. .00 44. .32 1SG1902
ATOM 1902 C LEU 253 86. .597 22. .089 36. .590 1. .00 44. .32 1SG1903
ATOM 1903 O LEU 253 85, .890 22, .327 37. .569 1. .00 44. .32 1SG1904
ATOM 1904 N GLN 254 87, .632 21, .231 36. .649 1. .00 51, .42 1SG1905
ATOM 1905 CA GLN 254 87, .897 20, .489 37. .846 1. .00 51, .42 1SG1906
ATOM 1906 CB GLN 254 89, .173 19, .641 37. .733 1. .00 51. .42 1SG1907
ATOM 1907 CG GLN 254 89, .083 18, .544 36. .673 1. .00 51. .42 1SG1908
ATOM 1908 CD GLN 254 90. .415 17. .813 36. .663 1. .00 51. .42 1SG1909
ATOM 1909 OEl GLN 254 91. .128 17. .810 35. .661 1. .00 51. .42 1SG1910
ATOM 1910 NE2 GLN 254 90. .764 17. .179 37. .815 1. .00 51. .42 1SG1911
ATOM 1911 C GLN 254 88. .100 21. .471 38. .956 1. .00 51. .42 1SG1912
ATOM 1912 O GLN 254 87, .583 21. .280 40. .055 1. .00 51. .42 1SG1913
ATOM 1913 N LYS 255 88, .856 22. .557 38. .709 1. .00 57. .36 1SG1914
ATOM 1914 CA LYS 255 88, .960 23, .559 39. .730 1. .00 57, .36 1SG1915
ATOM 1915 CB LYS 255 90, .235 24. .415 39. .619 1. .00 57, .36 1SG1916
ATOM 1916 CG LYS 255 90, .507 25, .306 40, .835 1. .00 57, .36 1SG1917
ATOM 1917 CD LYS 255 89, .400 26, .317 41, .140 1. .00 57, .36 1SG1918
ATOM 1918 CE LYS 255 88, .479 25, .892 42, .287 1. .00 57. .36 1SG1919
ATOM 1919 NZ LYS 255 87, .508 26, .969 42, .585 1. .00 57, .36 1SG1920
ATOM 1920 C LYS 255 87, .786 24, .433 39, .431 1. .00 57, .36 1SG1921
ATOM 1921 O LYS 255 87, .902 25, .427 38, .719 1. .00 57, .36 1SG1922
ATOM 1922 N SER 256 86, .628 24, .092 40, .023 1, .00 57, .38 1SG1923
ATOM 1923 CA SER 256 85. .346 24. .616 39. .641 1. .00 57, .38 1SG1924
ATOM 1924 CB SER 256 84. .222 24. .296 40. .639 1. .00 57. .38 1SG1925
ATOM 1925 OG SER 256 82 , .970 24. .644 40. .072 1. .00 57. .38 1SG1926
ATOM 1926 C SER 256 85, .324 26. .089 39, .362 1. .00 57. .38 1SG1927
ATOM 1927 O SER 256 85, .956 26. .894 40. .045 1. .00 57. .38 1SG1928
ATOM 1928 N PHE 257 84 , .568 26. .442 38. .292 1. .00 53. .11 1SG1929
ATOM 1929 CA PHE 257 84, .378 27. .786 37. .825 1. .00 53. .11 1SG1930
ATOM 1930 CB PHE 257 84, .634 27, .929 36. .312 1. .00 53. .11 1SG1931
ATOM 1931 CG PHE 257 84. .791 29, .380 36. .020 1. .00 53. .11 1SG1932
ATOM 1932 CDl PHE 257 85. .998 29, .999 36. .247 1. .00 53, .11 1SG1933
ATOM 1933 CD2 PHE 257 83, .745 30, .116 35. .516 1. .00 53, .11 1SG1934
ATOM 1934 CE1 PHE 257 86, .162 31, .339 35, .986 1. .00 53, .11 1SG1935
ATOM 1935 CE2 PHE 257 83, .901 31, .456 35. .253 1. .00 53, .11 1SG1936
ATOM 1936 CZ PHE 257 85, .109 32. .068 35, .490 1. .00 53, .11 1SG1937
ATOM 1937 C PHE 257 82, .942 28. .122 38, .089 1. .00 53, .11 1SG1938
ATOM 1938 O PHE 257 82. .036 27. .453 37. .588 1. .00 53, .11 1SG1939
ATOM 1939 N HIS 258 82. .704 29. .171 38. .905 1. ,00 46. .05 1SG1940
ATOM 1940 CA HIS 258 81. .368 29. .590 39. .228 1. ,00 46. .05 1SG1941
ATOM 1941 NDl HIS 258 80. .106 26. .739 40. .511 1. .00 46. .05 1SG1942
ATOM 1942 CG HIS 258 80. .955 27. .714 40. .985 1. ,00 46. .05 1SG1943
ATOM 1943 CB HIS 258 80. .874 29. .168 40. .626 1. ,00 46. .05 1SG1944
ATOM 1944 NE2 HIS 258 81. .467 25. .745 41. .962 1. ,00 46. .05 1SG1945
ATOM 1945 CD2 HIS 258 81. .784 27. .087 41. .863 1. ,00 46. .05 1SG1946
ATOM 1946 CE1 HIS 258 80. .457 25. .581 41. ,127 1. .00 46. .05 1SG1947
ATOM 1947 C HIS 258 81. .413 31. .081 39. ,361 1. ,00 46. .05 1SG1948
ATOM 1948 0 HIS 258 82. .486 31. .661 39. ,526 1. ,00 46. .05 1SG1949
ATOM 1949 N VAL 259 80. .245 31. .754 39. ,289 1. ,00 39. .94 1SG1950
ATOM 1950 CA VAL 259 80. .249 33. .161 39. ,580 1. ,00 39. .94 1SG1951
ATOM 1951 CB VAL 259 80. .495 34. .089 38. .421 1. ,00 39. .94 1SG1952
ATOM 1952 CGI VAL 259 79. .197 34. .280 37. ,624 1. .00 39. .94 1SG1953
ATOM 1953 CG2 VAL 259 81. .062 35. .406 38. ,979 1. .00 39. .94 1SG1954 ATOM 1954 C VAL 259 78..910 33,.498 40,.149 1..00 39..94 1SG1955
ATOM 1955 O VAL 259 77. .927 32. .802 39. ,898 1. .00 39. .94 1SG1956
ATOM 1956 N ASN 260 78. .841 34, .578 40. .952 1. .00 37. .16 1SG1957
ATOM 1957 CA ASN 260 77. .586 34, .958 41. ,528 1. .00 37. .16 1SG1958
ATOM 1958 CB ASN 260 77. .609 35, .076 43. .061 1. .00 37. .16 1SG1959
ATOM 1959 CG ASN 260 77. .688 33. .664 43. .624 1. .00 37. .16 1SG1960
ATOM 1960 ODl ASN 260 77. .542 32. .684 42 , .895 1. .00 37. .16 1SG1961
ATOM 1961 ND2 ASN 260 77. .910 33 .552 44. .961 1, .00 37, .16 1SG1962
ATOM 1962 C ASN 260 77. .224 36, .294 40. .974 1. .00 37. .16 1SG1963
ATOM 1963 O ASN 260 78. .083 37 .150 40, .763 1, .00 37, .16 1SG1964
ATOM 1964 N ILE 261 75. .920 36, .501 40, .714 1. .00 38. .02 1SG1965
ATOM 1965 CA ILE 261 75, .483 37 .740 40, .146 1. .00 38, .02 1SG1966
ATOM 1966 CB ILE 261 74. .671 37, .572 38. .900 1. .00 38. .02 1SG1967
ATOM 1967 CG2 ILE 261 74. .147 38, .957 38. .486 1, .00 38, .02 1SG1968
ATOM 1968 CGI ILE 261 75. .521 36, .896 37. .816 1. .00 38. .02 1SG1969
ATOM 1969 CDl ILE 261 75. .855 35 .433 38. .102 1, .00 38, .02 1SG1970
ATOM 1970 C ILE 261 74 , .623 38, .422 41, .150 1, .00 38. .02 1SG1971
ATOM 1971 O ILE 261 73, .742 37 .809 41, .752 1, .00 38, .02 1SG1972
ATOM 1972 N GLN 262 74 .880 39 .727 41, .358 1, .00 39, .72 1SG1973
ATOM 1973 CA GLN 262 74, .148 40. .483 42, .326 1, .00 39, .72 1SG1974
ATOM 1974 CB GLN 262 75 .047 41 .210 43, .340 1, .00 39 .72 1SG1975
ATOM 1975 CG GLN 262 75, .858 40 .264 44, .226 1, .00 39, .72 1SG1976
ATOM 1976 CD GLN 262 76 .917 39 .602 43, .356 1, .00 39, .72 1SG1977
ATOM 1977 OEl GLN 262 77, .534 40 .246 42, .508 1, .00 39. .72 1SG1978
ATOM 1978 NE2 GLN 262 77 .131 38 .276 43, .566 1, .00 39. .72 1SG1979
ATOM 1979 C GLN 262 73, .366 41, .529 41, .604 1. ,00 39, .72 1SG1980
ATOM 1980 O GLN 262 73, .622 41 .828 40, .439 1. .00 39, .72 1SG1981
ATOM 1981 N ASP 263 72 .370 42 .102 42 .303 1. .00 41 .99 1SG1982
ATOM 1982 CA ASP 263 71. .502 43 .105 41, .754 1. .00 41, .99 1SG1983
ATOM 1983 CB ASP 263 70 .380 43 .528 42 .719 1. .00 41 .99 1SG1984
ATOM 1984 CG ASP 263 69 .372 44 .371 41, .944 1, .00 41, .99 1SG1985
ATOM 1985 ODl ASP 263 69 .487 44 .427 40, .690 1, .00 41 .99 1SG1986
ATOM 1986 OD2 ASP 263 68. .476 44 .971 42, .597 1. .00 41, .99 1SG1987
ATOM 1987 C ASP 263 72 .305 44 .325 41, .451 1. .00 41, .99 1SG1988
ATOM 1988 O ASP 263 71, .980 45, .077 40. .535 1. .00 41, .99 1SG1989
ATOM 1989 N THR 264 73 .373 44 .558 42. .232 1. .00 41, .81 1SG1990
ATOM 1990 CA THR 264 74 .184 45 .733 42 .104 1. .00 41 .81 1SG1991
ATOM 1991 CB THR 264 75, .277 45 .776 43, .131 1. .00 41, .81 1SG1992
ATOM 1992 OGl THR 264 75 .946 47 .028 43, .091 1. .00 41, .81 1SG1993
ATOM 1993 CG2 THR 264 76, .263 44 .628 42, .858 1. .00 41. .81 1SG1994
ATOM 1994 C THR 264 74 .828 45 .795 40, .752 1. .00 41. .81 1SG1995
ATOM 1995 O THR 264 74, .947 46 .873 40, .171 1. .00 41. .81 1SG1996
ATOM 1996 N MET 265 75 .264 44 .641 40, .214 1. .00 41, .46 1SG1997
ATOM 1997 CA MET 265 75, .986 44, .624 38. .973 1. ,00 41. .46 1SG1998
ATOM 1998 CB MET 265 76, .450 43 .214 38. .578 1. .00 41. .46 1SG1999
ATOM 1999 CG MET 265 77, .530 42 .654 39, .505 1. .00 41. ,46 1SG2000
ATOM 2000 SD MET 265 78, .073 40 .970 39. .091 1. .00 41. .46 1SG2001
ATOM 2001 CE MET 265 79 .356 40 .893 40. .374 1. .00 41. .46 1SG2002
ATOM 2002 C MET 265 75, .134 45 .160 37, .867 1. .00 41. .46 1SG2003
ATOM 2003 O MET 265 75, .623 45 .869 36, .988 1. .00 41. .46 1SG2004
ATOM 2004 N ILE 266 73, .833 44, .830 37, .868 1. ,00 44. .09 1SG2005
ATOM 2005 CA ILE 266 72, .964 45 .298 36, .829 1. .00 44. .09 1SG2006
ATOM 2006 CB ILE 266 71, .614 44, .638 36. .815 1. ,00 44. .09 1SG2007
ATOM 2007 CG2 ILE 266 70, .830 45, .115 38. .046 1. .00 44. .09 1SG2008
ATOM 2008 CGI ILE 266 70, .893 44, .942 35. .495 1. .00 44. .09 1SG2009
ATOM 2009 CDl ILE 266 71, .569 44, .312 34. .282 1. .00 44. .09 1SG2010
ATOM 2010 C ILE 266 72. .749 46, .764 37. .008 1. ,00 44. .09 1SG2011 ATOM 2011 0 ILE 266 72..689 47,.273 38.126 1..00 44..09 1SG2012
ATOM 2012 N GLY 267 72, .652 47, .487 35 .880 1. .00 49. .95 1SG2013
ATOM 2013 CA GLY 267 72, .457 48. .903 35 .917 1. .00 49. .95 1SG2014
ATOM 2014 C GLY 267 70, .994 49. .160 35 .763 1. .00 49, .95 1SG2015
ATOM 2015 O GLY 267 70, .184 48. .818 36 .623 1. .00 49. .95 1SG2016
ATOM 2016 N GLU 268 70 .637 49. .804 34 .643 1, .00 64. .49 1SG2017
ATOM 2017 CA GLU 268 69 .299 50. .204 34 .320 1, .00 64. .49 1SG2018
ATOM 2018 CB GLU 268 69 .237 50, .947 32 .975 1. .00 64, .49 1SG2019
ATOM 2019 CG GLU 268 70, .074 52, .229 32 .939 1. .00 64, .49 1SG2020
ATOM 2020 CD GLU 268 69, .998 52. .800 31 .529 1. .00 64, .49 1SG2021
ATOM 2021 OEl GLU 268 69, .123 52. .334 30 .751 1. .00 64, .49 1SG2022
ATOM 2022 OE2 GLU 268 70, .813 53. .705 31 .210 1. .00 64, .49 1SG2023
ATOM 2023 C GLU 268 68 .429 48. .991 34 .179 1, .00 64, .49 1SG2024
ATOM 2024 O GLU 268 67 .239 49. .038 34 .488 1. .00 64, .49 1SG2025
ATOM 2025 N LEU 269 68 .998 47. .867 33 .704 1. .00 79, .87 1SG2026
ATOM 2026 CA LEU 269 68, .226 46, .690 33 .416 1. .00 79, .87 1SG2027
ATOM 2027 CB LEU 269 69. .074 45, .502 32 .927 1. .00 79. .87 1SG2028
ATOM 2028 CG LEU 269 69, .773 45. .766 31 .581 1. .00 79. .87 1SG2029
ATOM 2029 CD2 LEU 269 70 .381 44. .478 31 .001 1. .00 79 .87 1SG2030
ATOM 2030 CDl LEU 269 70 .789 46, .913 31 .698 1. .00 79, .87 1SG2031
ATOM 2031 C LEU 269 67 .456 46, .240 34 .619 1. .00 79, .87 1SG2032
ATOM 2032 O LEU 269 67, .808 46, .468 35 .776 1. .00 79, .87 1SG2033
ATOM 2033 N PRO 270 66, .346 45, .641 34 .276 1. .00 91, .31 1SG2034
ATOM 2034 CA PRO 270 65, .345 45. .177 35 .207 1. .00 91, .31 1SG2035
ATOM 2035 CD PRO 270 65 .791 45. .868 32 .954 1. .00 91 .31 1SG2036
ATOM 2036 CB PRO 270 64 .088 44. .911 34 .369 1. .00 91 .31 1SG2037
ATOM 2037 CG PRO 270 64 .560 44. .957 32 .906 1, .00 91 .31 1SG2038
ATOM 2038 C PRO 270 65 .543 44. .099 36 .233 1. .00 91, .31 1SG2039
ATOM 2039 O PRO 270 65, .018 44. .254 37 .328 1, .00 91, .31 1SG2040
ATOM 2040 N PRO 271 66, .286 43, .087 35 .981 1. .00 93, .42 1SG2041
ATOM 2041 CA PRO 271 66, .205 41. .837 36 .688 1. .00 93, .42 1SG2042
ATOM 2042 CD PRO 271 67 .510 43. .210 35 .206 1. .00 93 .42 1SG2043
ATOM 2043 CB PRO 271 67 .282 40, .967 36 .041 1, .00 93, .42 1SG2044
ATOM 2044 CG PRO 271 68, .340 41, .975 35 .568 1. .00 93, .42 1SG2045
ATOM 2045 C PRO 271 66, .145 41. .433 38 .120 1. .00 93, .42 1SG2046
ATOM 2046 O PRO 271 65. .127 40. .856 38 .495 1. .00 93, .42 1SG2047
ATOM 2047 N GLN - 272 67. .166 41. .665 38 .951 1. .00 82, .36 1SG2048
ATOM 2048 CA GLN 272 67 .079 40. .820 40 .103 1. .00 82, .36 1SG2049
ATOM 2049 CB GLN 272 68 .432 40. .197 40 .477 1. .00 82, .36 1SG2050
ATOM 2050 CG GLN 272 69. .563 41. .193 40 .676 1. .00 82, .36 1SG2051
ATOM 2051 CD GLN 272 70. .391 41. .267 39 .390 1. .00 82. .36 1SG2052
ATOM 2052 OEl GLN 272 71, .527 40. .797 39 .348 1. .00 82, .36 1SG2053
ATOM 2053 NE2 GLN 272 69, .821 41. .868 38, .312 1. .00 82. .36 1SG2054
ATOM 2054 C GLN 272 66. .415 41. .424 41, .287 1. ,00 82. .36 1SG2055
ATOM 2055 O GLN 272 67. .065 41. .875 42 .228 1. .00 82. .36 1SG2056
ATOM 2056 N THR 273 65, .068 41. .367 41 .267 1. .00 65. .96 1SG2057
ATOM 2057 CA THR 273 64. .240 41. .804 42, .349 1. .00 65. .96 1SG2058
ATOM 2058 CB THR 273 63. .809 43. .235 42, .221 1. ,00 65. .96 1SG2059
ATOM 2059 OGl THR 273 63. .040 43. ,411 41, .041 1. ,00 65. .96 1SG2060
ATOM 2060 CG2 THR 273 65. .066 44. ,124 42, .167 1. ,00 65. .96 1SG2061
ATOM 2061 C THR 273 63. .014 40. .938 42, .312 1. .00 65. .96 1SG2062
ATOM 2062 O THR 273 62. .631 40. .442 41, .253 1. .00 65. .96 1SG2063
ATOM 2063 N THR 274 62. .363 40. .728 43, .472 1. .00 51. .48 1SG2064
ATOM 2064 CA THR 274 61. .209 39. ,878 43, .534 1. .00 51. .48 1SG2065
ATOM 2065 CB THR 274 60. .575 39. ,757 44. .896 1. .00 51. .48 1SG2066
ATOM 2066 OGl THR 274 60. ,114 41. 028 45. .329 1. 00 51. .48 1SG2067
ATOM 2067 CG2 THR 274 61. ,560 39. 177 45. .919 1. 00 51. 48 1SG2068 ATOM 2068 C THR 274 60..160 40..536 42,.719 1..00 51,.48 1SG2069
ATOM 2069 0 THR 274 59. .388 39 .867 42, .041 1. .00 51 .48 1SG2070
ATOM 2070 N LYS 275 60. .094 41. .878 42, .793 1. .00 41, .14 1SG2071
ATOM 2071 CA LYS 275 59, .064 42 .593 42 .100 1. .00 41 .14 1SG2072
ATOM 2072 CB LYS 275 59, .122 44 .119 42 .278 1, .00 41 .14 1SG2073
ATOM 2073 CG LYS 275 58, .633 44. .635 43 .630 1, .00 41, .14 1SG2074
ATOM 2074 CD LYS 275 58, .790 46 .151 43 .770 1, .00 41 .14 1SG2075
ATOM 2075 CE LYS 275 58 .059 46 .748 44 .972 1. .00 41 .14 1SG2076
ATOM 2076 NZ LYS 275 58, .250 48 .215 44, .993 1. .00 41. .14 1SG2077
ATOM 2077 C LYS 275 59, .172 42 .364 40 .629 1, .00 41 .14 1SG2078
ATOM 2078 O LYS 275 58 .170 42 .099 39 .967 1, .00 41 .14 1SG2079
ATOM 2079 N THR 276 60, .390 42 .456 40, .069 1, .00 38. .20 1SG2080
ATOM 2080 CA THR 276 60, .516 42 .295 38, .649 1, .00 38 .20 1SG2081
ATOM 2081 CB THR 276 61 .932 42 .415 38 .163 1, .00 38 .20 1SG2082
ATOM 2082 OGl THR 276 62, .462 43 .689 38, .495 1, .00 38. .20 1SG2083
ATOM 2083 CG2 THR 276 61 .951 42 .217 36, .638 1, .00 38 .20 1SG2084
ATOM 2084 C THR 276 60 .051 40 .923 38 .301 1, .00 38 .20 1SG2085
ATOM 2085 0 THR 276 59, .262 40 .735 37, .376 1, .00 38 .20 1SG2086
ATOM 2086 N LEU 277 60 .507 39 .929 39. .077 1, .00 41 .94 1SG2087
ATOM 2087 CA LEU 277 60 .134 38 .566 38 .858 1 .00 41 .94 1SG2088
ATOM 2088 CB LEU 277 60, .824 37 .559 39, .799 1, .00 41 .94 1SG2089
ATOM 2089 CG LEU 277 62 .280 37 .231 39 .414 1, .00 41 .94 1SG2090
ATOM 2090 CD2 LEU 277 62 .833 36 .086 40 .280 1 .00 41 .94 1SG2091
ATOM 2091 CDl LEU 277 63, .176 38, .480 39, .420 1, .00 41 .94 1SG2092
ATOM 2092 C LEU 277 58 .664 38 .448 39, .064 1, .00 41 .94 1SG2093
ATOM 2093 O LEU 277 58 .034 37 .533 38 .547 1, .00 41 .94 1SG2094
ATOM 2094 N ALA 278 58, .078 39, .367 39, .843 1, .00 46 .51 1SG2095
ATOM 2095 CA ALA 278 56, .696 39, .298 40, .216 1, .00 46 .51 1SG2096
ATOM 2096 CB ALA 278 56 .258 40 .481 41, .097 1 .00 46 .51 1SG2097
ATOM 2097 C ALA 278 55, .819 39, .292 39. .006 1, .00 46 .51 1SG2098
ATOM 2098 O ALA 278 54 .765 38, .658 39. .024 1, .00 46 .51 1SG2099
ATOM 2099 N ARG 279 56 .185 40 .015 37. .932 1 .00 58 .09 1SG2100
ATOM 2100 CA ARG 279 55, .279 40, .007 36. .822 1, .00 58 .09 1SG2101
ATOM 2101 CB ARG 279 55. .762 40, .838 35, .622 1. .00 58. .09 1SG2102
ATOM 2102 CG ARG 279 54 .764 40 .795 34, .463 1, .00 58 .09 1SG2103
ATOM 2103 CD ARG 279 55, .304 41, .329 33. .138 1, .00 58. .09 1SG2104
ATOM 2104 NE ARG 279 54 .251 41, .067 32, .117 1, .00 58 .09 1SG2105
ATOM 2105 CZ ARG 279 54 .490 41 .314 30, . 191 1, .00 58 .09 1SG2106
ATOM 2106 NHl ARG 279 55, .688 41, .837 30. .402 1. .00 58. .09 1SG2107
ATOM 2107 NH2 ARG 279 53, .529 41, .031 29, .871 1. .00 58. .09 1SG2108
ATOM 2108 C ARG 279 55 .112 38, .601 36, .322 1, .00 58 .09 1SG2109
ATOM 2109 0 ARG 279 53, .987 38. .131 36. .152 1. .00 58. .09 1SG2110
ATOM 2110 N PHE 280 56, .229 37, .907 36. .038 1. .00 73, .42 1SG2111
ATOM 2111 CA PHE 280 56, .141 36, .561 35, .548 1. .00 73, .42 1SG2112
ATOM 2112 CB PHE 280 57. .312 36. .167 34. .624 1. .00 73. .42 1SG2113
ATOM 2113 CG PHE 280 58. .621 36. .304 35. .319 1. .00 73. .42 1SG2114
ATOM 2114 CDl PHE 280 59. .293 37. .505 35, .302 1, .00 73, .42 1SG2115
ATOM 2115 CD2 PHE 280 59. .180 35. .234 35. .979 1. .00 73. .42 1SG2116
ATOM 2116 CE1 PHE 280 60. .505 37. .639 35. .936 1. .00 73. .42 1SG2117
ATOM 2117 CE2 PHE 280 60. .393 35, .363 36. .613 1. .00 73. .42 1SG2118
ATOM 2118 CZ PHE 280 61. .057 36. .566 36. ,593 1. .00 73. .42 1SG2119
ATOM 2119 C PHE 280 55. .908 35. .491 36. .583 1. .00 73. .42 1SG2120
ATOM 2120 0 PHE 280 55. .092 34. .600 36. .345 1. .00 73. .42 1SG2121
ATOM 2121 N ILE 281 56. ,626 35. .495 37. .736 1. .00 85. ,97 1SG2122
ATOM 2122 CA ILE 281 56. .407 34. ,389 38. .625 1. .00 85. .97 1SG2123
ATOM 2123 CB ILE 281 57. .512 33. .371 38. ,579 1. ,00 85. .97 1SG2124
ATOM 2124 CG2 ILE 281 57. .212 32. .285 39. ,628 1. ,00 85. .97 1SG2125 ATOM 2125 CGI ILE 281 57..646 32..802 37..157 1..00 85,.97 1SG2126
ATOM 2126 CDl ILE 281 58. .889 31. .935 36. .961 1. .00 85. .97 1SG2127
ATOM 2127 C ILE 281 56. .242 34. .773 40. .067 1. .00 85, .97 1SG2128
ATOM 2128 O ILE 281 57. .201 34. .743 40, .838 1. .00 85, .97 1SG2129
ATOM 2129 N PRO 282 55. .061 35, .138 40, .469 1. .00 95, .26 1SG2130
ATOM 2130 CA PRO 282 54, .755 35, .161 41, .868 1. .00 95, .26 1SG2131
ATOM 2131 CD PRO 282 54, .178 35. .976 39. .684 1. .00 95. .26 1SG2132
ATOM 2132 CB PRO 282 53 , .510 36. .036 42, .013 1. .00 95. .26 1SG2133
ATOM 2133 CG PRO 282 52 , .942 36. .140 40, .582 1. .00 95, .26 1SG2134
ATOM 2134 C PRO 282 54, .504 33, .705 41, .847 1. .00 95 .26 1SG2135
ATOM 2135 O PRO 282 53, .901 33, .285 40, .863 1, .00 95 .26 1SG2136
ATOM 2136 N GLU 283 54. .869 32. .869 42. .826 1. .00 92, .43 1SG2137
ATOM 2137 CA GLU 283 55. .341 32. .953 44. .166 1. .00 92, .43 1SG2138
ATOM 2138 CB GLU 283 55. .806 31, .573 44, .615 1. .00 92, .43 1SG2139
ATOM 2139 CG GLU 283 56. .547 31, .582 45, .942 1. .00 92 .43 1SG2140
ATOM 2140 CD GLU 283 57, .036 30, .160 46 .142 1. .00 92 .43 1SG2141
ATOM 2141 OEl GLU 283 56, .506 29. .260 45. .440 1. .00 92, .43 1SG2142
ATOM 2142 OE2 GLU 283 57. .949 29. .954 46, .988 1. .00 92, .43 1SG2143
ATOM 2143 C GLU 283 56 , .479 33, .879 44, .477 1. .00 92 .43 1SG2144
ATOM 2144 O GLU 283 56. .484 34. .345 45, .608 1. .00 92 .43 1SG2145
ATOM 2145 N VAL 284 57, .452 34 .172 43 .583 1. .00 78 .19 1SG2146
ATOM 2146 CA VAL 284 58. .624 34, .948 43, .949 1. .00 78, .19 1SG2147
ATOM 2147 CB VAL 284 59, .375 35, .412 42, .738 1. .00 78, .19 1SG2148
ATOM 2148 CGI VAL 284 60, .603 36, .225 43, .174 1. .00 78 .19 1SG2149
ATOM 2149 CG2 VAL 284 59, .689 34, .184 41 .875 1, .00 78 .19 1SG2150
ATOM 2150 C VAL 284 58, .227 36 .187 44 .699 1. .00 78 .19 1SG2151
ATOM 2151 O VAL 284 58, .754 36. .460 45, .777 1. .00 78, .19 1SG2152
ATOM 2152 N ALA 285 57, .272 36. .953 44, .163 1. .00 61 .44 1SG2153
ATOM 2153 CA ALA 285 56, .805 38. .109 44, .872 1, .00 61 .44 1SG2154
ATOM 2154 CB ALA 285 55, .848 38 .967 44, .034 1. .00 61 .44 1SG2155
ATOM 2155 C ALA 285 56, .068 37 .677 46 .106 1. .00 61 .44 1SG2156
ATOM 2156 O ALA 285 56. .217 38. .284 47, .164 1. .00 61, .44 1SG2157
ATOM 2157 N VAL 286 55, .227 36. .624 46, .003 1. .00 47, .21 1SG2158
ATOM 2158 CA VAL 286 . 54 , .398 36, .243 47, .118 1. .00 47 .21 1SG2159
ATOM 2159 CB VAL 286 53 , .458 35, .121 46, .781 1, .00 47 .21 1SG2160
ATOM 2160 CGI VAL 286 52, .684 34 .733 48 .053 1. .00 47 .21 1SG2161
ATOM 2161 CG2 VAL 286 52. .558 35, .567 45, .616 1. .00 47. .21 1SG2162
ATOM 2162 C VAL 286 55. .197 35, .795 48, .309 1, .00 47. .21 1SG2163
ATOM 2163 O VAL 286 55. .044 36, .338 49, .402 1. .00 47, .21 1SG2164
ATOM 2164 N ALA 287 56. .056 34, .773 48 .130 1. .00 39, .77 1SG2165
ATOM 2165 CA ALA 287 56. .838 34, .207 49 .191 1. .00 39 .77 1SG2166
ATOM 2166 CB ALA 287 57. .592 32 , .939 48, .754 1. .00 39, .77 1SG2167 ATOM 2167 C ALA 287 57. .860 35, .181 49, .678 1. .00 39, .77 1SG2168
ATOM 2168 O ALA 287 58. .029 35, .354 50, .885 1. .00 39, .77 1SG2169
ATOM 2169 N TYR 288 58. .576 35, .844 48, .749 1. .00 39, .55 1SG2170
ATOM 2170 CA TYR 288 59. .615 36, .741 49, .168 1, .00 39, .55 1SG2171
ATOM 2171 CB TYR 288 60. .918 36. .494 48, .394 1. ,00 39. .55 1SG2172
ATOM 2172 CG TYR 288 61. .236 35. .045 48, .527 1. .00 39. .55 1SG2173
ATOM 2173 CDl TYR 288 61. .942 34. .566 49. .605 1. .00 39. .55 1SG2174
ATOM 2174 CD2 TYR 288 60. .811 34. .160 47. .562 1. .00 39. .55 1SG2175
ATOM 2175 CE1 TYR 288 62, .226 33, .225 49. .710 1. .00 39. .55 1SG2176
ATOM 2176 CE2 TYR 288 61. .090 32. .817 47. .663 1. ,00 39. .55 1SG2177
ATOM 2177 CZ TYR 288 61. .802 32. .348 48. .740 1. ,00 39. .55 1SG2178
ATOM 2178 OH TYR 288 62. .097 30. .973 48. .854 1. ,00 39. .55 1SG2179
ATOM 2179 C TYR 288 59. .164 38. .115 48. .794 1. .00 39. .55 1SG2180
ATOM 2180 O TYR 288 59. .417 38. .572 47. .681 1. .00 39. .55 1SG2181
ATOM 2181 N PRO 289 58. .525 38. .803 49. .694 1. .00 43. .11 1SG2182 ATOM 2182 CA PRO 289 58..014 40..100 49..355 1.00 43..11 1SG2183
ATOM 2183 CD PRO 289 57. .719 38. .156 50. .714 1. 00 43. .11 1SG2184
ATOM 2184 CB PRO 289 56. .871 40. .387 50. .334 1. .00 43. ,11 1SG2185
ATOM 2185 CG PRO 289 57. .025 39. .321 51. .434 1. .00 43. .11 1SG2186
ATOM 2186 C PRO 289 59. .036 41. .187 49. .292 1. .00 43. .11 1SG2187
ATOM 2187 O PRO 289 59. .863 41. .294 50. .198 1. ,00 43. .11 1SG2188
ATOM 2188 N LYS 290 58, .958 42. .011 48, .229 1. .00 46. .08 1SG2189
ATOM 2189 CA LYS 290 59. .757 43. .184 48. .020 1. .00 46. .08 1SG2190
ATOM 2190 CB LYS 290 59. .222 44. .459 48, .695 1. .00 46. ,08 1SG2191
ATOM 2191 CG LYS 290 59. .871 45. .722 48, .121 1. .00 46. ,08 1SG2192
ATOM 2192 CD LYS 290 59. .160 47. .022 48, .502 1. ,00 46. .08 1SG2193
ATOM 2193 CE LYS 290 59, .531 48, .207 47, .606 1. .00 46. .08 1SG2194
ATOM 2194 NZ LYS 290 60, .997 48, .404 47, .589 1. .00 46. .08 1SG2195
ATOM 2195 C LYS 290 61, .163 42, .973 48, .459 1. .00 46. .08 1SG2196
ATOM 2196 O LYS 290 61. .644 43, .645 49, .370 1. .00 46. .08 1SG2197
ATOM 2197 N SER 291 61, .871 42, .029 47, .824 1. .00 51. .27 1SG2198
ATOM 2198 CA SER 291 63, .239 41, .840 48, .188 1. .00 51. .27 1SG2199
ATOM 2199 CB SER 291 63. .536 40, .456 48, .786 1. .00 51. .27 1SG2200
ATOM 2200 OG SER 291 62. .845 40, .294 50, .015 1. .00 51. .27 1SG2201
ATOM 2201 C SER 291 63 .996 41 .931 46 .917 1. .00 51, .27 1SG2202
ATOM 2202 O SER 291 63 .402 42 .045 45 .847 1. .00 51, .27 1SG2203
ATOM 2203 N LYS- 292 65 .335 41 .950 47 .017 1. .00 57, .13 1SG2204
ATOM 2204 CA LYS 292 66, .147 41, .856 45, .846 1. .00 57. .13 1SG2205
ATOM 2205 CB LYS 292 67, .346 42, .813 45, .862 1. .00 57. .13 1SG2206
ATOM 2206 CG LYS 292 66, .918 44, .278 45, .778 1. .00 57. .13 1SG2207
ATOM 2207 CD LYS 292 68 .024 45, .268 46, .143 1. .00 57, .13 1SG2208
ATOM 2208 CE LYS 292 67 .588 46 .732 46 .055 1. .00 57, .13 1SG2209
ATOM 2209 NZ LYS 292 66 .677 47 .060 47 .175 1. .00 57, .13 1SG2210
ATOM 2210 C LYS 292 66 .649 40 .473 45 .982 1. .00 57, .13 1SG2211
ATOM 2211 O LYS 292 67 .827 40 .184 46 .180 1. .00 57, .13 1SG2212
ATOM 2212 N PRO 293 65, .682 39. .623 45, .893 1. .00 59. .54 1SG2213
ATOM 2213 CA PRO 293 65, .905 38, .259 46, .165 1. .00 59, .54 1SG2214
ATOM 2214 CD PRO 293 64 .675 39 .759 44 .869 1. .00 59, .54 1SG2215
ATOM 2215 CB PRO 293 64 .602 37 .553 45 .834 1. .00 59, .54 1SG2216
ATOM 2216 CG PRO 293 64 .141 38 .340 44 .604 1, .00 59, .54 1SG2217
ATOM 2217 C PRO 293 66 .961 37 .761 45 .267 1. .00 59, .54 1SG2218
ATOM 2218 O PRO 293 67 .801 36 .991 45 .724 1. .00 59, .54 1SG2219
ATOM 2219 N LEU 294 66, .979 38. .230 44, .008 1. .00 60. .75 1SG2220
ATOM 2220 CA LEU 294 67, .777 37. .479 43 .115 1. .00 60. .75 1SG2221
ATOM 2221 CB LEU 294 67, .474 37 .668 41 .615 1. .00 60. .75 1SG2222
ATOM 2222 CG LEU 294 66 .124 37 .102 41 .133 1. .00 60. .75 1SG2223
ATOM 2223 CD2 LEU 294 66 .072 37 .005 39 .599 1. .00 60. .75 1SG2224
ATOM 2224 CDl LEU 294 64 .942 37 .885 41 .721 1. .00 60. .75 1SG2225
ATOM 2225 C LEU 294 69 .234 37 .644 43 .296 1. .00 60, .75 1SG2226
ATOM 2226 O LEU 294 69 .824 38 .691 43 .033 1. .00 60, .75 1SG2227
ATOM 2227 N THR 295 69, .822 36. .524 43, .744 1. .00 56. .99 1SG2228
ATOM 2228 CA THR 295 71, .226 36. .294 43 .775 1. .00 56. .99 1SG2229
ATOM 2229 CB THR 295 71, .805 36 .053 45 .153 1. .00 56. .99 1SG2230
ATOM 2230 OGl THR 295 73 .207 35 .843 45 .059 1. .00 56. .99 1SG2231
ATOM 2231 CG2 THR 295 71 .125 34 .858 45 .846 1. .00 56, .99 1SG2232
ATOM 2232 C THR 295 71 .321 35 .052 42 .949 1, .00 56. .99 1SG2233
ATOM 2233 O THR 295 70 .711 34 .034 43 .274 1, .00 56. .99 1SG2234
ATOM 2234 N THR 296 72. .042 35. .102 41, .816 1. .00 49. .96 1SG2235
ATOM 2235 CA THR 296 72. .022 33. .927 40, .998 1. .00 49. .96 1SG2236
ATOM 2236 CB THR 296 71, .540 34. .176 39, .597 1. .00 49. .96 1SG2237
ATOM 2237 OGl THR 296 72, .390 35. .096 38, .928 1. .00 49. .96 1SG2238
ATOM 2238 CG2 THR 296 70, .106 34. .727 39, .674 1. .00 49. .96 1SG2239 ATOM 2239 C THR 296 73.396 33.355 40,.935 1..00 49,.96 1SG2240
ATOM 2240 O THR 296 74 .390 34 .079 40, .893 1. .00 49, .96 1SG2241
ATOM 2241 N GLN 297 73, .475 32, .012 40. .945 1. .00 44. .77 1SG2242
ATOM 2242 CA GLN 297 74, .744 31, .353 40, .920 1. .00 44. .77 1SG2243
ATOM 2243 CB GLN 297 74, .857 30 .215 41, .945 1. .00 44. .77 1SG2244
ATOM 2244 CG GLN 297 74, .803 30 .667 43, .403 1. .00 44. .77 1SG2245
ATOM 2245 CD GLN 297 74 .885 29 .410 44, .254 1, .00 44. .77 1SG2246
ATOM 2246 OEl GLN 297 75 .763 29 .277 45, .104 1, .00 44. .77 1SG2247
ATOM 2247 NE2 GLN 297 73 .941 28 .460 44, .017 1. .00 44, .77 1SG2248
ATOM 2248 C GLN 297 74 .896 30 .704 39 .585 1. .00 44, .77 1SG2249
ATOM 2249 O GLN 297 73 .978 30 .051 39, .091 1. .00 44. .77 1SG2250
ATOM 2250 N ILE 298 76, .077 30, .871 38, .960 1. .00 41. .78 1SG2251
ATOM 2251 CA ILE 298 76 .310 30, .218 37, .706 1. .00 41. ,78 1SG2252
ATOM 2252 CB ILE 298 76 .656 31, .143 36. .562 1. .00 41. .78 1SG2253
ATOM 2253 CG2 ILE 298 78 .062 31, .702 36. .799 1. .00 41, .78 1SG2254
ATOM 2254 CGI ILE 298 76 .527 30 .437 35. .198 1. .00 41, ,78 1SG2255
ATOM 2255 CDl ILE 298 77 .530 29, .308 34, .972 1. .00 41, ,78 1SG2256
ATOM 2256 C ILE 298 77 .458 29 .282 37, .931 1, .00 41, .78 1SG2257
ATOM 2257 O ILE 298 78 .467 29 .637 38, .540 1, .00 41. .78 1SG2258
ATOM 2258 N LYS 299 77 .298 28 .027 37 .475 1. .00 39, .22 1SG2259
ATOM 2259 CA LYS 299 78 .312 27, .031 37. .643 1. .00 39. .22 1SG2260
ATOM 2260 CB LYS 299 77, .886 25, .914 38, .603 1, .00 39. .22 1SG2261
ATOM 2261 CG LYS 299 77 .322 26, .419 39, .930 1. .00 39. .22 1SG2262
ATOM 2262 CD LYS 299 76 .559 25, .332 40, .685 1. .00 39. .22 1SG2263
ATOM 2263 CE LYS 299 75 .768 25, .845 41, .889 1. .00 39. .22 1SG2264
ATOM 2264 NZ LYS 299 74 .917 24, .760 42, .426 1. .00 39, .22 1SG2265
ATOM 2265 C LYS 299 78 .426 26, .360 36, .316 1. .00 39, .22 1SG2266
ATOM 2266 O LYS 299 ' 77 .545 26 .503 35, .470 1. .00 39. .22 1SG2267
ATOM 2267 N ILE 300 79 .518 25 .604 36, .098 1. .00 39. .27 1SG2268
ATOM 2268 CA ILE 300 79, .629 24. .892 34 , .861 1. .00 39. .27 1SG2269
ATOM 2269 CB ILE 300 80, .962 25. .056 34 , .196 1. .00 39, ,27 1SG2270
ATOM 2270 CG2 ILE 300 80, .977 24. .162 32, .950 1. .00 39, .27 1SG2271
ATOM 2271 CGI ILE 300 81 .205 26. .540 33, .868 1 , .00 39, .27 1SG2272
ATOM 2272 CDl ILE 300 80, .162 27, .136 32, .922 1. .00 39, .27 1SG2273
ATOM 2273 C ILE 300 79 .408 23, .454 35, .208 1, .00 39, .27 1SG2274
ATOM 2274 O ILE 300 80 .127 22, .881 36, .023 1, .00 39, .27 1SG2275
ATOM 2275 N LYS 301 78 .346 22, .855 34, .634 1. .00 39, .15 1SG2276
ATOM 2276 CA LYS 301 77 .989 21, .502 34, .954 1. .00 39. .15 1SG2277
ATOM 2277 CB LYS 301 76, .627 21. .070 34. .380 1. .00 39. .15 1SG2278
ATOM 2278 CG LYS 301 76, .242 19. .645 34. .792 1. .00 39, .15 1SG2279
ATOM 2279 CD LYS 301 74, .771 19. .297 34. .552 1. ,00 39. .15 1SG2280
ATOM 2280 CE LYS 301 74, .402 17. .870 34. .969 1. ,00 39, .15 1SG2281
ATOM 2281 NZ LYS 301 72, .966 17. .615 34. .707 1. .00 39. .15 1SG2282
ATOM 2282 C LYS 301 79, .014 20. .526 34. .457 1. .00 39, .15 1SG2283
ATOM 2283 O LYS 301 79, .402 19. .614 35. .185 1. .00 39, .15 1SG2284
ATOM 2284 N LYS 302 79, .478 20. .690 33. .200 1. .00 37. .70 1SG2285
ATOM 2285 CA LYS 302 80, .398 19. .736 32. .638 1. .00 37. .70 1SG2286
ATOM 2286 CB LYS 302 79. .771 18. .885 31. ,521 1. .00 37, .70 1SG2287
ATOM 2287 CG LYS 302 78. .605 18. .009 31. .980 1. .00 37, ,70 1SG2288
ATOM 2288 CD LYS 302 77. .774 17. .463 30. ,817 1. .00 37, ,70 1SG2289
ATOM 2289 CE LYS 302 76, .594 16. .594 31. ,252 1. .00 37, .70 1SG2290
ATOM 2290 NZ LYS 302 75, .748 16. .277 30. .080 1. .00 37, .70 1SG2291
ATOM 2291 C LYS 302 81. .524 20. .488 32. .002 1. ,00 37, .70 1SG2292
ATOM 2292 O LYS 302 81. .465 21. .705 31. .846 1. ,00 37, .70 1SG2293
ATOM 2293 N PRO 303 82. .568 19. .786 31. .641 1. ,00 38. .49 1SG2294
ATOM 2294 CA PRO 303 83. .670 20. .447 30. ,998 1. ,00 38, ,49 1SG2295
ATOM 2295 CD PRO 303 83. ,005 18. 636 32. 417 1. 00 38. 49 1SG2296 ATOM 2296 CB PRO 303 84.818 19,.441 31.002 1..00 38,.49 1SG2297
ATOM 2297 CG PRO 303 84 .535 18, .587 32 .253 1. .00 38 .49 1SG2298
ATOM 2298 C PRO 303 83, .245 20. .927 29. .649 1. .00 38, .49 1SG2299
ATOM 2299 O PRO 303 82, .588 20. .175 28 .931 1. .00 38, .49 1SG2300
ATOM 2300 N PRO 304 83 .603 22, .124 29 .281 1, .00 38 .49 1SG2301
ATOM 2301 CA PRO 304 83 .185 22, .636 28 .007 1 .00 38 .49 1SG2302
ATOM 2302 CD PRO 304 83 .829 23, .187 30 .243 1. .00 38, .49 1SG2303
ATOM 2303 CB PRO 304 83 .345 24. .157 28 .078 1, .00 38 .49 1SG2304
ATOM 2304 CG PRO 304 84 .153 24. .406 29 .365 1 .00 38 .49 1SG2305
ATOM 2305 C PRO 304 83, .940 21. .983 26 .896 1, .00 38 .49 1SG2306
ATOM 2306 O PRO 304 85, .116 21. .667 27 .068 1, .00 38 .49 1SG2307
ATOM 2307 N LYS 305 83 .290 21. .777 25 .737 1, .00 38 .67 1SG2308
ATOM 2308 CA LYS 305 83 .972 21. .129 24 .659 1 .00 38 .67 1SG2309
ATOM 2309 CB LYS 305 83, .213 19. .910 24. .105 1, .00 38, .67 1SG2310
ATOM 2310 CG LYS 305 83 .125 18. .755 25 .106 1, .00 38 .67 1SG2311
ATOM 2311 CD LYS 305 82 .123 17. .668 24 .710 1 .00 38 .67 1SG2312
ATOM 2312 CE LYS 305 82 .061 16. .498 25 .694 1 .00 38 .67 1SG2313
ATOM 2313 NZ LYS 305 81, .186 16. .839 26 .839 1, .00 38 .67 1SG2314
ATOM 2314 C LYS 305 84 .131 22. ,112 23 .549 1, .00 38 .67 1SG2315
ATOM 2315 O LYS 305 83 .275 22. .969 23 .340 1 .00 38 .67 1SG2316
ATOM 2316 N VAL 306 85 .262 22. .027 22 .821 1 .00 40 .54 1SG2317
ATOM 2317 CA VAL 306 85, .465 22, .913 21 .715 1, .00 40 .54 1SG2318
ATOM 2318 CB VAL 306 86 .617 23. .861 21 .893 1 .00 40 .54 1SG2319
ATOM 2319 CGI VAL 306 86 .317 24. .769 23 .097 1 .00 40 .54 1SG2320
ATOM 2320 CG2 VAL 306 87, .921 23. .056 22 .021 1. .00 40 .54 1SG2321
ATOM 2321 C VAL 306 85, .770 22. .062 20 .527 1, .00 40 .54 1SG2322
ATOM 2322 O VAL 306 86 .572 21, .132 20 .604 1 .00 40 .54 1SG2323
ATOM 2323 N THR 307 85 .123 22, .349 19 .383 1 .00 41 .26 1SG2324
ATOM 2324 CA THR 307 85, .412 21, .554 18 .230 1, .00 41 .26 1SG2325
ATOM 2325 CB THR 307 84. .225 20, .852 17 .636 1, .00 41 .26 1SG2326
ATOM 2326 OGl THR 307 83 .281 21, .792 17 .148 1 .00 41 .26 1SG2327
ATOM 2327 CG2 THR 307 83 .589 19, .964 18 .719 1 .00 41 .26 1SG2328
ATOM 2328 C THR 307 85. .980 22. .459 17, .192 1, .00 41 .26 1SG2329
ATOM 2329 O THR 307 85, .521 23. .587 17 .018 1, .00 41 .26 1SG2330
ATOM 2330 N MET 308 87 .021 21. .981 16 .483 1, .00 40 .72 1SG2331
ATOM 2331 CA MET 308 87 .623 22. .804 15 .479 1 .00 40 .72 1SG2332
ATOM 2332 CB MET 308 89, .147 22. .955 15, .640 1, .00 40 .72 1SG2333
ATOM 2333 CG MET 308 89, .550 23. .835 16 .826 1, .00 40 .72 1SG2334
ATOM 2334 SD MET 308 89, .209 23. .118 18 .461 1, .00 40 .72 1SG2335
ATOM 2335 CE MET 308 89 .752 24, .585 19 .385 1, .00 40 .72 1SG2336
ATOM 2336 C MET 308 87, .352 22. .207 14, .132 1. .00 40, .72 1SG2337
ATOM 2337 O MET 308 87, .587 21. .021 13, .902 1. .00 40. .72 1SG2338
ATOM 2338 N LYS 309 86, .825 23. .040 13 .209 1, .00 39 .89 1SG2339
ATOM 2339 CA LYS 309 86. ,543 22. .634 11, .860 1. .00 39. .89 1SG2340
ATOM 2340 CB LYS 309 85. .081 22. .232 11, .602 1. .00 39. .89 1SG2341
ATOM 2341 CG LYS 309 84. .092 23. .394 11, .706 1. .00 39. .89 1SG2342
ATOM 2342 CD LYS 309 82, .744 23. .096 11, .047 1. .00 39. .89 1SG2343
ATOM 2343 CE LYS 309 81. ,992 21. ,929 11, .688 1. .00 39. .89 1SG2344
ATOM 2344 NZ LYS 309 80, ,711 21. .705 10, .980 1. .00 39. .89 1SG2345
ATOM 2345 C LYS 309 86, .822 23. .823 10, .995 1. .00 39. .89 1SG2346
ATOM 2346 O LYS 309 86, .860 24. .948 11, .478 1. .00 39. .89 1SG2347
ATOM 2347 N THR 310 86. .962 23. .613 9. .674 1. .00 37. .58 1SG2348
ATOM 2348 CA THR 310 87. .353 24, ,653 8. .763 1. .00 37. .58 1SG2349
ATOM 2349 CB THR 310 87. .349 24. ,199 7. .334 1. .00 37. .58 1SG2350
ATOM 2350 OGl THR 310 86. .035 23. .835 6. .938 1. .00 37. .58 1SG2351
ATOM 2351 CG2 THR 310 88. .296 22. .994 7. .204 1. .00 37. .58 1SG2352
ATOM 2352 C THR 310 86. .410 25. .809 8. .874 1. ,00 37. .58 1SG2353 ATOM 2353 O THR 310 86.816 26.960 8.707 1.00 37.58 1SG2354
ATOM 2354 N GLY 311 85. .117 25. .545 9. .126 1. .00 37. ,46 1SG2355
ATOM 2355 CA GLY 311 84. ,190 26. .636 9. .208 1. .00 37. 46 1SG2356
ATOM 2356 C GLY 311 84. ,578 27. ,549 10. .333 1. .00 37. ,46 1SG2357
ATOM 2357 o GLY 311 84. ,592 28. ,768 10. .163 1. .00 37. 46 1SG2358
ATOM 2358 N LYS 312 84. ,893 26. .993 11. .521 1, .00 39. .07 1SG2359
ATOM 2359 CA LYS 312 85. .271 27. .836 12. .621 1. .00 39. .07 1SG2360
ATOM 2360 CB LYS 312 84. ,285 28. .988 12. .879 1. .00 39. ,07 1SG2361
ATOM 2361 CG LYS 312 84. .875 30. .111 13. .731 1. .00 39. .07 1SG2362
ATOM 2362 CD LYS 312 84. .076 31. .412 13. .650 1. .00 39. .07 1SG2363
ATOM 2363 CE LYS 312 84. .766 32. .591 14, .337 1. .00 39. .07 1SG2364
ATOM 2364 NZ LYS 312 83. ,983 33. .829 14, .131 1. .00 39. .07 1SG2365
ATOM 2365 C LYS 312 85. .297 26. .972 13 .842 1. .00 39. .07 1SG2366
ATOM 2366 O LYS 312 85. .081 25, .764 13, .757 1. .00 39. .07 1SG2367
ATOM 2367 N SER 313 85. .575 27, .568 15, .022 1. .00 40. .85 1SG2368
ATOM 2368 CA SER 313 85. .617 26. .762 16, .208 1. .00 40. .85 1SG2369
ATOM 2369 CB SER 313 86, .853 27, .021 17 .085 1, .00 40. .85 1SG2370
ATOM 2370 OG SER 313 88. .032 26, .668 16, .377 1. .00 40. .85 1SG2371
ATOM 2371 C SER 313 84. .412 27. .075 17 .026 1. .00 40. .85 1SG2372
ATOM 2372 O SER 313 84. .105 28, .239 17, .281 1. .00 40. .85 1SG2373
ATOM 2373 N LEU 314 83. .678 26, .030 17 .459 1 .00 44, .06 1SG2374
ATOM 2374 CA LEU 314 82. .527 26 .312 18 .257 1, .00 44, .06 1SG2375
ATOM 2375 CB LEU 314 81. .174 25, .936 17 .610 1. .00 44, .06 1SG2376
ATOM 2376 CG LEU 314 81, .086 24, .523 17, .010 1, .00 44. .06 1SG2377
ATOM 2377 CD2 LEU 314 81, .248 23, .443 18 .087 1 .00 44, .06 1SG2378
ATOM 2378 CDl LEU 314 82, .051 24 .358 15 .825 1. .00 44, .06 1SG2379
ATOM 2379 C LEU 314 82, .684 25. .671 19, .597 1 .00 44, .06 1SG2380
ATOM 2380 O LEU 314 83 .332 24 .636 19 .742 1 .00 44, .06 1SG2381
ATOM 2381 N LEU 315 82, .112 26 .326 20 .629 1 .00 45 .39 1SG2382
ATOM 2382 CA LEU 315 82, .222 25 .874 21 .985 1 .00 45, .39 1SG2383
ATOM 2383 CB LEU 315 82, .664 26, .974 22, .961 1 .00 45, .39 1SG2384
ATOM 2384 CG LEU 315 82, .759 26 .489 24 .419 1 .00 45, .39 1SG2385
ATOM 2385 CD2 LEU 315 82, .917 27 .665 25, .394 1, .00 45, .39 1SG2386
ATOM 2386 CDl LEU 315 83. .851 25 .421 24 .586 1 .00 45, .39 1SG2387
ATOM 2387 C LEU 315 80. .887 25, .396 22, .460 1, .00 45, .39 1SG2388
ATOM 2388 O LEU 315 79, .848 25 .917 22 .054 1 .00 45, .39 1SG2389
ATOM 2389 N HIS 316 80, .894 24 .369 23 .339 1, .00 46 .54 1SG2390
ATOM 2390 CA HIS 316 79. .667 23 .852 23 .874 1 .00 46, .54 1SG2391
ATOM 2391 NDl HIS 316 80, .485 21 .506 21, .438 1, .00 46. .54 1SG2392
ATOM 2392 CG HIS 316 79, .413 21 .972 22 .167 1 .00 46. .54 1SG2393
ATOM 2393 CB HIS 316 79. .479 22 .345 23 .619 1, .00 46. .54 1SG2394
ATOM 2394 NE2 HIS 316 78, .748 21 .556 20 .051 1, .00 46, .54 1SG2395
ATOM 2395 CD2 HIS 316 78, .361 21 .997 21. .304 1, .00 46. .54 1SG2396
ATOM 2396 CE1 HIS 316 80, .032 21 .273 20 .181 1 .00 46. .54 1SG2397
ATOM 2397 C HIS 316 79. .703 24 .007 25 .365 1, .00 46, .54 1SG2398
ATOM 2398 O HIS 316 80, .108 23 .093 26. .081 1 .00 46. .54 1SG2399
ATOM 2399 N LEU 317 79 .266 25 .170 25 .881 1 .00 46, .95 1SG2400
ATOM 2400 CA LEU 317 79, .240 25 .386 27 .298 1 .00 46, .95 1SG2401
ATOM 2401 CB LEU 317 79, .468 26 .869 27 .666 1, .00 46, .95 1SG2402
ATOM 2402 CG LEU 317 79, .463 27, .209 29, .172 1, .00 46. .95 1SG2403
ATOM 2403 CD2 LEU 317 80 .424 26 .293 29 .948 1 .00 46, .95 1SG2404
ATOM 2404 CDl LEU 317 78 .045 27 .228 29 .763 1, .00 46 .95 1SG2405
ATOM 2405 C LEU 317 77, .907 24, .933 27 .794 1, .00 46, .95 1SG2406
ATOM 2406 O LEU 317 76, .933 24, .913 27, .041 1, .00 46. .95 1SG2407
ATOM 2407 N HIS 318 77 .853 24 .504 29 .070 1 .00 45. .84 1SG2408
ATOM 2408 CA HIS 318 76 .617 24 .123 29, .688 1. .00 45. .84 1SG2409
ATOM 2409 NDl HIS 318 77, .742 21, .375 27 .968 1, .00 45. .84 1SG2410 ATOM 2410 CG HIS 318 76..565 21..926 28..427 1..00 45.,84 1SG2411
ATOM 2411 CB HIS 318 76. .427 22. .598 29. .762 1. .00 45. ,84 1SG2412
ATOM 2412 NE2 HIS 318 76. ,231 21. .058 26. .369 1. .00 45. .84 1SG2413
ATOM 2413 CD2 HIS 318 75. .653 21. .723 27. .435 1. .00 45. .84 1SG2414
ATOM 2414 CE1 HIS 318 77. .487 20. .870 26. .736 1. .00 45. ,84 1SG2415
ATOM 2415 C HIS 318 76. ,737 24. .630 31. .090 1. ,00 45. ,84 1SG2416
ATOM 2416 O HIS 318 77. .760 24 , .411 31, .737 1. .00 45. .84 1SG2417
ATOM 2417 N SER 319 75. .714 25. .341 31. .609 1. .00 44. .05 1SG2418
ATOM 2418 CA SER 319 75. .893 25. .825 32, .947 1. .00 44. .05 1SG2419
ATOM 2419 CB SER 319 76. .171 27, .332 33, .079 1. .00 44. .05 1SG2420
ATOM 2420 OG SER 319 74. .950 28. .057 33. .045 1. .00 44. ,05 1SG2421
ATOM 2421 C SER 319 74. .651 25. .585 33. .734 1. .00 44. .05 1SG2422
ATOM 2422 O SER 319 73. .580 25. .319 33. .188 1. .00 44. .05 1SG2423
ATOM 2423 N THR 320 74. .789 25. .672 35. .070 1. .00 44. .21 1SG2424
ATOM 2424 CA THR 320 73. .673 25, .492 35, .945 1. .00 44. .21 1SG2425
ATOM 2425 CB THR 320 73. .964 24, .494 37, .027 1. .00 44. .21 1SG2426
ATOM 2426 OGl THR 320 74. .339 23 .250 36. .455 1. .00 44, .21 1SG2427
ATOM 2427 CG2 THR 320 72, .709 24, .309 37, .891 1, .00 44. .21 1SG2428
ATOM 2428 C THR 320 73. .447 26, .823 36, .589 1. .00 44. .21 1SG2429
ATOM 2429 O THR 320 74. .341 27 .365 37, .239 1. .00 44, .21 1SG2430
ATOM 2430 N LEU 321 72. .243 27, .398 36, .404 1. .00 47, .28 1SG2431
ATOM 2431 CA LEU 321 71. .956 28, .690 36. .959 1. .00 47, .28 1SG2432
ATOM 2432 CB LEU 321 71. .361 29 .667 35. .931 1. .00 47, .28 1SG2433
ATOM 2433 CG LEU 321 72. .365 30, .112 34, .857 1. .00 47, .28 1SG2434
ATOM 2434 CD2 LEU 321 73. .615 30 .711 35, .515 1. .00 47, .28 1SG2435
ATOM 2435 CDl LEU 321 71. .723 31 .083 33, .855 1. .00 47, .28 1SG2436
ATOM 2436 C LEU 321 70. .932 28, .519 38. .032 1. .00 47, .28 1SG2437
ATOM 2437 O LEU 321 69, .868 27 .954 37. .792 1, .00 47, .28 1SG2438
ATOM 2438 N GLU 322 71, .224 29, .007 39, .253 1. .00 50, .38 1SG2439
ATOM 2439 CA GLU 322 70, .263 28. .864 40. .307 1. .00 50, .38 1SG2440
ATOM 2440 CB GLU 322 70, .780 28 .015 41. .481 1. .00 50, .38 1SG2441
ATOM 2441 CG GLU 322 69, .687 27. .580 42. .458 1. .00 50, .38 1SG2442
ATOM 2442 CD GLU 322 70 .291 26 .547 43 .397 1. .00 50 .38 1SG2443
ATOM 2443 OEl GLU 322 71, .543 26 .415 43, .410 1. .00 50, .38 1SG2444
ATOM 2444 OE2 GLU 322 69, .506 25. .870 44 , .112 1. .00 50, .38 1SG2445
ATOM 2445 C GLU 322 69 .937 30 .231 40. .827 1. .00 50 .38 1SG2446
ATOM 2446 O GLU 322 70, .820 31. .073 40, .985 1, .00 50, .38 1SG2447
ATOM 2447 N MET 323 68, .640 30, .486 41, .100 1. .00 54, .94 1SG2448
ATOM 2448 CA MET 323 68 .227 31, .766 41, .596 1. .00 54, .94 1SG2449
ATOM 2449 CB MET 323 66. .999 32, .350 40. .869 1. .00 54. .94 1SG2450
ATOM 2450 CG MET 323 67 .297 32 .832 39, .447 1. .00 54. .94 1SG2451
ATOM 2451 SD MET 323 67. .639 31, .510 38, .249 1, .00 54. .94 1SG2452
ATOM 2452 CE MET 323 68. .048 32, .647 36. .893 1. .00 54. .94 1SG2453
ATOM 2453 C MET 323 67. .859 31, .608 43, .030 1. .00 54. .94 1SG2454
ATOM 2454 O MET 323 67. .207 30, .642 43, .421 1. .00 54. .94 1SG2455
ATOM 2455 N PHE 324 68, .293 32, .570 43. .862 1. .00 57. .34 1SG2456
ATOM 2456 CA PHE 324 67, .973 32, .542 45, .254 1, .00 57. .34 1SG2457
ATOM 2457 CB PHE 324 69, .199 32, .473 46. .181 1. .00 57. .34 1SG2458
ATOM 2458 CG PHE 324 69 .857 31, .144 46. .030 1. .00 57, .34 1SG2459
ATOM 2459 CDl PHE 324 70, .773 30, .920 45. .028 1, .00 57. .34 1SG2460
ATOM 2460 CD2 PHE 324 69, .559 30. .122 46. .903 1. .00 57. .34 1SG2461
ATOM 2461 CE1 PHE 324 71, .380 29. .693 44 , .896 1, .00 57, .34 1SG2462
ATOM 2462 CE2 PHE 324 70, .163 28, .895 46, .775 1. .00 57, .34 1SG2463
ATOM 2463 CZ PHE 324 71. .075 28. .678 45. .770 1. .00 57. .34 1SG2464
ATOM 2464 C PHE 324 67, .330 33. .850 45. .517 1. .00 57, .34 1SG2465
ATOM 2465 O PHE 324 67. .392 34. .746 44. .681 1. .00 57. .34 1SG2466
ATOM 2466 N ALA 325 66. .664 33. .973 46. .676 1. .00 57. .51 1SG2467 ATOM 2467 CA ALA 325 66.,090 35..223 47..061 1.,00 57..51 1SG2468
ATOM 2468 CB ALA 325 64. ,666 35. .105 47. .627 1. .00 57. .51 1SG2469
ATOM 2469 C ALA 325 66. .983 35. .666 48. .161 1. .00 57. .51 1SG2470
ATOM 2470 O ALA 325 67. .504 34. .838 48. .894 1. .00 57. .51 1SG2471
ATOM 2471 N ALA 326 67. .235 36, .973 48. .288 1. .00 58. .56 1SG2472
ATOM 2472 CA ALA 326 68. .109 37, .407 49, .324 1. .00 58. .56 1SG2473
ATOM 2473 CB ALA 326 69. .164 38, .427 48 .858 1. .00 58. .56 1SG2474
ATOM 2474 C ALA 326 67. .281 38. .072 50, .361 1. .00 58. .56 1SG2475
ATOM 2475 O ALA 326 66. .470 38. .951 50, .077 1. .00 58. .56 1SG2476
ATOM 2476 N ARG 327 67. .480 37, .653 51, .616 1. .00 59. .78 1SG2477
ATOM 2477 CA ARG 327 66. .804 38, .277 52, .707 1. .00 59. .78 1SG2478
ATOM 2478 CB ARG 327 66. .973 37, .531 54, .042 1. .00 59. .78 1SG2479
ATOM 2479 CG ARG 327 66. .178 38, .149 55 .194 1. .00 59. .78 1SG2480
ATOM 2480 CD ARG 327 66. .630 37, .672 56 .575 1, .00 59, .78 1SG2481
ATOM 2481 NE ARG 327 67, .721 38 .581 57 .027 1. .00 59, .78 1SG2482
ATOM 2482 CZ ARG 327 68. .171 38. .506 58, .313 1. .00 59. .78 1SG2483
ATOM 2483 NHl ARG 327 67. .649 37, .574 59, .162 1. .00 59. .78 1SG2484
ATOM 2484 NH2 ARG 327 69, .140 39, .360 58 .753 1. .00 59, .78 1SG2485
ATOM 2485 C ARG 327 67, .469 39, .610 52 .846 1. .00 59, .78 1SG2486
ATOM 2486 O ARG 327 68, .383 39 .929 52 .089 1. .00 59, .78 1SG2487
ATOM 2487 N TRP 328 67, .015 40 .451 53 .791 1 .00 58, .88 1SG2488
ATOM 2488 CA TRP 328 67, .660 41 .724 53 .916 1 .00 58 .88 1SG2489
ATOM 2489 CB TRP 328 67. .069 42, .650 54, .990 1. .00 58, .88 1SG2490
ATOM 2490 CG TRP 328 67. .684 44, .029 54 .925 1, .00 58, .88 1SG2491
ATOM 2491 CD2 TRP 328 67. .189 45, .089 54 .093 1. .00 58, .88 1SG2492
ATOM 2492 CDl TRP 328 68. .781 44 .525 55 .569 1. .00 58, .88 1SG2493
ATOM 2493 NE1 TRP 328 69. .006 45 .826 55 .181 1, .00 58, .88 1SG2494
ATOM 2494 CE2 TRP 328 68. .030 46 .186 54 .273 1 .00 58 .88 1SG2495
ATOM 2495 CE3 TRP 328 66. .119 45 .143 53 .242 1 .00 58 .88 1SG2496
ATOM 2496 CZ2 TRP 328 67. .816 47 .358 53 .603 1 .00 58 .88 1SG2497
ATOM 2497 CZ3 TRP 328 65, .904 46, .327 52 .573 1, .00 58, .88 1SG2498
ATOM 2498 CH2 TRP 328 66, .735 47, .414 52 .749 1, .00 58, .88 1SG2499
ATOM 2499 C TRP 328 69, .086 41, .444 54 .266 1, .00 58, .88 1SG2500
ATOM 2500 O TRP 328 69, .988 42. .168 53 .847 1, .00 58 .88 1SG2501
ATOM 2501 N ARG 329 69, .325 40 .375 55 .049 1, .00 56 .96 1SG2502
ATOM 2502 CA ARG 329 70. .674 40 .002 55 .357 1, .00 56 .96 1SG2503
ATOM 2503 CB ARG 329 70. .807 38 .895 56 .413 1 .00 56 .96 1SG2504
ATOM 2504 CG ARG 329 72. .264 38. .488 56 .650 1, .00 56, .96 1SG2505
ATOM 2505 CD ARG 329 72. .428 37. .223 57, .493 1, .00 56. .96 1SG2506
ATOM 2506 NE ARG 329 72. .021 37 .548 58 .888 1, .00 56. .96 1SG2507
ATOM 2507 CZ ARG 329 72. .912 37 .389 59 .909 1, .00 56, .96 1SG2508
ATOM 2508 NHl ARG 329 74, .166 36 .915 59 .647 1, .00 56, .96 1SG2509
ATOM 2509 NH2 ARG 329 72, .554 37 .696 61 .190 1, .00 56, .96 1SG2510
ATOM 2510 C ARG 329 71, .233 39 .460 54 .084 1, .00 56, .96 1SG2511
ATOM 2511 O ARG 329 70, .500 39 .106 53 .170 1, .00 56, .96 1SG2512
ATOM 2512 N SER 330 72. .561 39, .387 53. .968 1. .00 56. .97 1SG2513
ATOM 2513 CA SER 330 73. .159 39, .007 52. .724 1, .00 56. .97 1SG2514
ATOM 2514 CB SER 330 74. .695 39, .072 52 .766 1, .00 56. .97 1SG2515
ATOM 2515 OG SER 330 75. .229 38 .692 51 .506 1, .00 56. .97 1SG2516
ATOM 2516 C SER 330 72. .788 37, .615 52 .314 1, .00 56. .97 1SG2517
ATOM 2517 O SER 330 72, .767 37 .318 51 .121 1, .00 56 , .97 1SG2518
ATOM 2518 N LYS 331 72, .486 36 .708 53 .262 1, .00 55, .84 1SG2519
ATOM 2519 CA LYS 331 72. .251 35, .353 52, .846 1. .00 55. .84 1SG2520
ATOM 2520 CB LYS 331 72. .409 34, .295 53, .949 1. .00 55. .84 1SG2521
ATOM 2521 CG LYS 331 73. .891 33, .984 54, .178 1. .00 55. .84 1SG2522
ATOM 2522 CD LYS 331 74. .204 33, .083 55, .372 1, .00 55. .84 1SG2523
ATOM 2523 CE LYS 331 75. .693 32, .745 55, .480 1, .00 55. .84 1SG2524 ATOM 2524 NZ LYS 331 75..938 31..873 56,.649 1..00 55..84 1SG2525
ATOM 2525 C LYS 331 70. .947 35. .202 52, .136 1. .00 55. .84 1SG2526
ATOM 2526 O LYS 331 70. .059 36. .050 52, .220 1. .00 55. .84 1SG2527
ATOM 2527 N ALA 332 70. .828 34. .103 51 .362 1, .00 59. .90 1SG2528
ATOM 2528 CA ALA 332 69. .665 33. .936 50, .546 1. .00 59. .90 1SG2529
ATOM 2529 CB ALA 332 70. .013 33. .759 49, .057 1. .00 59. .90 1SG2530
ATOM 2530 C ALA 332 68. .886 32. .730 50, .953 1. .00 59. .90 1SG2531
ATOM 2531 O ALA 332 69. .420 31. .683 51 .319 1, .00 59. .90 1SG2532
ATOM 2532 N PRO 333 67, .594 32. .915 50 .904 1. .00 65. .83 1SG2533
ATOM 2533 CA PRO 333 66, .723 31. .805 51 .131 1, .00 65, .83 1SG2534
ATOM 2534 CD PRO 333 67, .057 34. .110 51 .548 1, .00 65, .83 1SG2535
ATOM 2535 CB PRO 333 65. .342 32. .399 51, .384 1. .00 65. .83 1SG2536
ATOM 2536 CG PRO 333 65. .669 33. .726 52, .087 1. .00 65. .83 1SG2537
ATOM 2537 C PRO 333 66, .801 30. .816 50, .036 1, .00 65. .83 1SG2538
ATOM 2538 O PRO 333 67, .191 31, .191 48 .925 1, .00 65. .83 1SG2539
ATOM 2539 N MET 334 66, .412 29, .564 50 .379 1. .00 67, .01 1SG2540
ATOM 2540 CA MET 334 66, .506 28, .410 49 .543 1. .00 67, .01 1SG2541
ATOM 2541 CB MET 334 65, .617 27. .237 49, .991 1. .00 67. .01 1SG2542
ATOM 2542 CG MET 334 65, .979 26. .711 51, .382 1. .00 67. .01 1SG2543
ATOM 2543 SD MET 334 67, .693 26. .128 51 .549 1. .00 67, .01 1SG2544
ATOM 2544 CE MET 334 67, .480 24, .671 50 .486 1. .00 67, .01 1SG2545
ATOM 2545 C MET 334 66, .098 28, .828 48 .190 1 .00 67, .01 1SG2546
ATOM 2546 O MET 334 65 .097 29, .516 47 .999 1, .00 67, .01 1SG2547
ATOM 2547 N SER 335 66 .938 28, .433 47 .228 1 .00 67 .63 1SG2548
ATOM 2548 CA SER 335 66, .836 28. .864 45, .876 1, .00 67, .63 1SG2549
ATOM 2549 CB SER 335 67. .701 28. .047 44 .909 1, .00 67, .63 1SG2550
ATOM 2550 OG SER 335 67. .182 26. .728 44 .818 1, .00 67, .63 1SG2551
ATOM 2551 C SER 335 65, .442 28. .734 45 .399 1, .00 67, .63 1SG2552
ATOM 2552 O SER 335 64 .706 27, .826 45 .781 1, .00 67, .63 1SG2553
ATOM 2553 N LEU 336 65 .040 29, .712 44 .569 1, .00 62 .26 1SG2554
ATOM 2554 CA LEU 336 63, .743 29. .672 43, .987 1, .00 62 , .26 1SG2555
ATOM 2555 CB LEU 336 63, .428 30. .915 43, .135 1, .00 62. .26 1SG2556
ATOM 2556 CG LEU 336 63. .243 32. .209 43 .947 1. .00 62. .26 1SG2557
ATOM 2557 CD2 LEU 336 62, .170 32. .031 45 .034 1, .00 62 , .26 1SG2558
ATOM 2558 CDl LEU 336 62, .935 33, .398 43 .025 1, .00 62. .26 1SG2559
ATOM 2559 C LEU 336 63, .708 28, .501 43 .061 1. .00 62. .26 1SG2560
ATOM 2560 O LEU 336 62 .818 27, .658 43 .149 1, .00 62. .26 1SG2561
ATOM 2561 N PHE 337 64 , .708 28. .405 42, .160 1. .00 56. .28 1SG2562
ATOM 2562 CA PHE 337 64, .705 27, .325 41, .218 1. .00 56. .28 1SG2563
ATOM 2563 CB PHE 337 63. .602 27, .477 40, .155 1. .00 56. .28 1SG2564
ATOM 2564 CG PHE 337 63, .728 28, .826 39, .531 1, .00 56. .28 1SG2565
ATOM 2565 CDl PHE 337 63, .202 29, .935 40, .148 1, .00 56. .28 1SG2566
ATOM 2566 CD2 PHE 337 64. .357 28, .990 38. .324 1. .00 56. .28 1SG2567
ATOM 2567 CE1 PHE 337 63. .304 31. .185 39. .584 1. .00 56. .28 1SG2568
ATOM 2568 CE2 PHE 337 64, .463 30. .23.7 37. .754 1. .00 56. .28 1SG2569
ATOM 2569 CZ PHE 337 63, .939 31. .340 38. .379 1. .00 56. .28 1SG2570
ATOM 2570 C PHE 337 66, .037 27. .223 40. .544 1. .00 56. .28 1SG2571
ATOM 2571 O PHE 337 66, .842 28, .155 40. .576 1. .00 56. .28 1SG2572
ATOM 2572 N LEU 338 66, .307 26, .056 39. .919 1. .00 51. .64 1SG2573
ATOM 2573 CA LEU 338 67, .563 25, .860 39. .252 1. .00 51. .64 1SG2574
ATOM 2574 CB LEU 338 68. .359 24. .658 39. .791 1. ,00 51. .64 1SG2575
ATOM 2575 CG LEU 338 69. .746 24. .496 39, .144 1. ,00 51. .64 1SG2576
ATOM 2576 CD2 LEU 338 70. .377 23. .142 39, .505 1. ,00 51. .64 1SG2577
ATOM 2577 CDl LEU 338 70. .653 25. .689 39. .489 1. ,00 51. ,64 1SG2578
ATOM 2578 C LEU 338 67. .290 25. .611 37. .797 1. ,00 51. .64 1SG2579
ATOM 2579 O LEU 338 66. .363 24. .884 37. .442 1. .00 51. .64 1SG2580
ATOM 2580 N LEU 339 68. ,100 26. .226 36. .909 1. 00 54. 91 1SG2581 ATOM 2581 CA LEU 339 67..899 26..057 35..498 1..00 54..91 1SG2582
ATOM 2582 CB LEU 339 67. .706 27, .378 34. .731 1. .00 54. .91 1SG2583
ATOM 2583 CG LEU 339 66. .518 28. .214 35. .225 1. .00 54. .91 1SG2584
ATOM 2584 CD2 LEU 339 66. .767 28. .730 36. .650 1. .00 54. .91 1SG2585
ATOM 2585 CDl LEU 339 65. .193 27. .451 35, .067 1. .00 54. .91 1SG2586
ATOM 2586 C LEU 339 69. .119 25. .430 34. .902 1. .00 54. .91 1SG2587
ATOM 2587 O LEU 339 70, .236 25. .643 35, .374 1. .00 54, .91 1SG2588
ATOM 2588 N GLU 340 68, .923 24. .624 33, .837 1. .00 62, .98 1SG2589
ATOM 2589 CA GLU 340 70. .041 24. .071 33, .129 1. .00 62. .98 1SG2590
ATOM 2590 CB GLU 340 69. .911 22, .586 32, .752 1, .00 62, .98 1SG2591
ATOM 2591 CG GLU 340 71. .149 22. .061 32, .017 1. .00 62. .98 1SG2592
ATOM 2592 CD GLU 340 71. .051 20. .546 31, .904 1. .00 62. .98 1SG2593
ATOM 2593 OEl GLU 340 70. .959 19. .877 32, .968 1. .00 62. .98 1SG2594
ATOM 2594 OE2 GLU 340 71, .069 20, .036 30, .752 1. .00 62, .98 1SG2595
ATOM 2595 C GLU 340 70. .105 24. .857 31. .869 1. .00 62. .98 1SG2596
ATOM 2596 O GLU 340 69. .102 25. .049 31. .186 1, .00 62, .98 1SG2597
ATOM 2597 N VAL 341 71, .300 25, .350 31. .529 1. .00 71, .53 1SG2598
ATOM 2598 CA VAL 341 71. .363 26. .260 30, .435 1. .00 71, .53 1SG2599
ATOM 2599 CB VAL 341 71. .610 27. .644 30, .980 1. .00 71, .53 1SG2600
ATOM 2600 CGI VAL 341 71. .932 28. .667 29, .878 1. .00 71, .53 1SG2601
ATOM 2601 CG2 VAL 341 70, .414 28 .007 31 .868 1. .00 71, .53 1SG2602
ATOM 2602 C VAL 341 72. .533 25. .937 29, .590 1. .00 71, .53 1SG2603
ATOM 2603 O VAL 341 73. .474 25. .281 30, .035 1. .00 71, .53 1SG2604
ATOM 2604 N HIS 342 72. .425 26. .379 28, .320 1. .00 82, .24 1SG2605
ATOM 2605 CA HIS 342 73. .518 26. .537 27, .423 1. .00 82 .24 1SG2606
ATOM 2606 NDl HIS 342 75, .088 28 .896 28 .401 1, .00 82 .24 1SG2607
ATOM 2607 CG HIS 342 74, .983 27. .618 28, .900 1. .00 82, .24 1SG2608
ATOM 2608 CB HIS 342 74, .907 26 .416 28 .023 1 .00 82 .24 1SG2609
ATOM 2609 NE2 HIS 342 74. .812 29. .086 30, .597 1, .00 82, .24 1SG2610
ATOM 2610 CD2 HIS 342 74, .822 27. .749 30, .242 1. .00 82, .24 1SG2611
ATOM 2611 CE1 HIS 342 74, .977 29. .735 29, .460 1. .00 82, .24 1SG2612
ATOM 2612 C HIS 342 73, .333 26. .078 26. .036 1. .00 82, .24 1SG2613
ATOM 2613 O HIS 342 72. .421 25, .325 25, .699 1. .00 82, .24 1SG2614
ATOM 2614 N PHE 343 74, .200 26, .637 25, .177 1. .00 79, .92 1SG2615
ATOM 2615 CA PHE 343 74. .112 26. .437 23. .770 1. .00 79, .92 1SG2616
ATOM 2616 CB PHE 343 73. .202 27, .464 23. .065 1, .00 79, .92 1SG2617
ATOM 2617 CG PHE 343 72. .839 26, .913 21. .724 1. .00 79 .92 1SG2618
ATOM 2618 CDl PHE 343 71, .993 25, .831 21, .651 1. ,00 79, .92 1SG2619
ATOM 2619 CD2 PHE 343 73. .341 27, .433 20, .552 1, .00 79, .92 1SG2620
ATOM 2620 CE1 PHE 343 71. .642 25, .289 20. .438 1. .00 79, .92 1SG2621
ATOM 2621 CE2 PHE 343 72. .991 26, .895 19, .335 1, .00 79, .92 1SG2622
ATOM 2622 CZ PHE 343 72. .137 25, .822 19. .273 1. ,00 79. .92 1SG2623
ATOM 2623 C PHE 343 75, .506 26, .560 23. .267 1. .00 79, .92 1SG2624
ATOM 2624 O PHE 343 76. .450 26, .427 24. .042 1. .00 79. .92 1SG2625
ATOM 2625 N ASN 344 75. .690 26, .778 21. .954 1. .00 73. .34 1SG2626
ATOM 2626 CA ASN 344 77, .029 26, .826 21. .456 1, .00 73. .34 1SG2627
ATOM 2627 CB ASN 344 77. .380 25, .612 20. .582 1. .00 73. .34 1SG2628
ATOM 2628 CG ASN 344 76, .385 25, .577 19. .432 1. .00 73. .34 1SG2629
ATOM 2629 ODl ASN 344 76. .651 26, .076 18. .340 1. .00 73. .34 1SG2630
ATOM 2630 ND2 ASN 344 75. .196 24, .968 19. .687 1. .00 73. .34 1SG2631
ATOM 2631 C ASN 344 77. .244 28, .051 20. .634 1. ,00 73. .34 1SG2632
ATOM 2632 O ASN 344 76. .306 28, .615 20. .072 1. .00 73. .34 1SG2633
ATOM 2633 N LEU 345 78. ,506 28. .530 20. .572 1. ,00 64. .88 1SG2634
ATOM 2634 CA LEU 345 78. .704 29. .644 19. .703 1. .00 64. .88 1SG2635
ATOM 2635 CB LEU 345 77. .983 30. .903 20. .216 1. .00 64 . .88 1SG2636
ATOM 2636 CG LEU 345 77. ,583 31. .965 19. .160 1. .00 64. .88 1SG2637
ATOM 2637 CD2 LEU 345 76. .851 31. .297 17. .987 1. .00 64. .88 1SG2638 ATOM 2638 CDl LEU 345 78..714 32.886 18.699 1.,00 64.,88 1SG2639
ATOM 2639 C LEU 345 80. .176 29. 753 19. 379 1. ,00 64. ,88 1SG2640
ATOM 2640 O LEU 345 80. .953 28. ,866 19. ,728 1. .00 64. .88 1SG2641
ATOM 2641 N LYS 346 80. .592 30. ,810 18. ,647 1. .00 54. .30 1SG2642
ATOM 2642 CA LYS 346 81. ,929 30. ,930 18. ,119 1. .00 54. .30 1SG2643
ATOM 2643 CB LYS 346 82. .085 31. ,973 16. .996 1. .00 54. .30 1SG2644
ATOM 2644 CG LYS 346 81. .468 31. ,592 15. .650 1. .00 54. .30 1SG2645
ATOM 2645 CD LYS 346 79. .943 31. 678 15. 612 1. .00 54. .30 1SG2646
ATOM 2646 CE LYS 346 79. .369 31. .507 14. ,204 1. .00 54. .30 1SG2647
ATOM 2647 NZ LYS 346 77. .901 31. .692 14. .228 1, .00 54, .30 1SG2648
ATOM 2648 C LYS 346 82, .970 31. .288 19. .130 1. .00 54. .30 1SG2649
ATOM 2649 O LYS 346 82, .740 32. .040 20. .077 1. .00 54. .30 1SG2650
ATOM 2650 N VAL 347 84. .181 30. .734 18. .904 1. .00 48. .05 1SG2651
ATOM 2651 CA VAL 347 85. .340 31. .034 19. .687 1. .00 48. .05 1SG2652
ATOM 2652 CB VAL 347 85, .970 29. .813 20. .293 1. .00 48. .05 1SG2653
ATOM 2653 CGI VAL 347 87, .277 30. .233 20. .985 1. .00 48. .05 1SG2654
ATOM 2654 CG2 VAL 347 84, .947 29. .144 21. .228 1. .00 48, .05 1SG2655
ATOM 2655 C VAL 347 86. .333 31. ,621 18. .733 1, .00 48, .05 1SG2656
ATOM 2656 O VAL 347 86. .835 30. .934 17. .844 1. .00 48, .05 1SG2657
ATOM 2657 N GLN 348 86 .635 32. .923 18, .891 1. .00 44, .51 1SG2658
ATOM 2658 CA GLN 348 87. .569 33. .574 18. .020 1, .00 44, .51 1SG2659
ATOM 2659 CB GLN 348 87, .296 35. .075 17. .824 1. .00 44 .51 1SG2660
ATOM 2660 CG GLN 348 86 .084 35, .385 16. .943 1. .00 44, .51 1SG2661
ATOM 2661 CD GLN 348 86. .519 35. .236 15. .492 1. .00 44, .51 1SG2662
ATOM 2662 OEl GLN 348 87, .023 34. .191 15. .080 1. .00 44, .51 1SG2663
ATOM 2663 NE2 GLN 348 86 .337 36. .322 14. .694 1. .00 44, .51 1SG2664
ATOM 2664 C GLN 348 88 .924 33. .452 18. .628 1 .00 44 .51 1SG2665
ATOM 2665 O GLN 348 89 .071 33. .369 19. .847 1. .00 44 .51 1SG2666
ATOM 2666 N TYR 349 89, .959 33. .423 17. .769 1. .00 42, .98 1SG2667
ATOM 2667 CA TYR 349 91, .298 33. .320 18. .263 1. .00 42, .98 1SG2668
ATOM 2668 CB TYR 349 91, .979 31. .986 17. .923 1, .00 42 .98 1SG2669
ATOM 2669 CG TYR 349 93 .418 32. .215 18, .209 1 .00 42 .98 1SG2670
ATOM 2670 CDl TYR 349 93 .846 32. .334 19, .505 1 .00 42 .98 1SG2671
ATOM 2671 CD2 TYR 349 94, .338 32. .307 17, .191 1, . 00 42 .98 1SG2672
ATOM 2672 CE1 TYR 349 95, .168 32, .556 19, .788 1 .00 42 .98 1SG2673
ATOM 2673 CE2 TYR 349 95 .668 32. .526 17, .468 1 .00 42 .98 1SG2674
ATOM 2674 CZ TYR 349 96 .085 32 .650 18 .771 1 .00 42 .98 1SG2675
ATOM 2675 OH TYR 349 97 .446 32. .876 19, .069 1 .00 42 .98 1SG2676
ATOM 2676 C TYR 349 92 .149 34. .398 17, .662 1 .00 42 .98 1SG2677
ATOM 2677 O TYR 349 92 .095 34. .650 16, .459 1 .00 42 .98 1SG2678
ATOM 2678 N SER 350 92 .977 35, .051 18. .509 1 .00 41 .47 1SG2679
ATOM 2679 CA SER 350 93 .861 36. .102 18. .078 1, .00 41. .47 1SG2680
ATOM 2680 CB SER 350 93 .269 37. .508 18. .271 1. .00 41 .47 1SG2681
ATOM 2681 OG SER 350 92 .108 37. .660 17 .468 1 .00 41 .47 1SG2682
ATOM 2682 C SER 350 95 .099 36, .020 18. .924 1 .00 41 .47 1SG2683
ATOM 2683 O SER 350 95 .137 35, .290 19. .912 1, .00 41. .47 1SG2684
ATOM 2684 N VAL 351 96, .165 36. .758 18. .552 1, .00 43. .13 1SG2685
ATOM 2685 CA VAL 351 97 .382 36. .669 19. .309 1, .00 43 .13 1SG2686
ATOM 2686 CB VAL 351 98 .483 35 .979 18 .558 1 .00 43 .13 1SG2687
ATOM 2687 CGI VAL 351 98 .729 36. .741 17, .245 1 .00 43 .13 1SG2688
ATOM 2688 CG2 VAL 351 99 .728 35, .918 19. .457 1, .00 43 .13 1SG2689
ATOM 2689 C VAL 351 97, .881 38. .042 19 .631 1 .00 43 .13 1SG2690
ATOM 2690 O VAL 351 97 .761 38, .973 18. .836 1, .00 43 .13 1SG2691
ATOM 2691 N HIS 352 98 .460 38, .192 20 .838 1 .00 44 .68 1SG2692
ATOM 2692 CA HIS 352 99 .061 39, .428 21. .246 1 .00 44 .68 1SG2693
ATOM 2693 NDl HIS 352 96, .852 41. .764 20. .667 1, .00 44 .68 1SG2694
ATOM 2694 CG HIS 352 96 .924 40, .717 21. .556 1 .00 44 .68 1SG2695 ATOM 2695 CB HIS 352 98..194 40,.257 22,.205 1..00 44,.68 1SG2696
ATOM 2696 NE2 HIS 352 94. .788 40 .966 20, .876 1. .00 44, .68 1SG2697
ATOM 2697 CD2 HIS 352 95, .655 40, .240 21. .674 1. .00 44, .68 1SG2698
ATOM 2698 CE1 HIS 352 95, .552 41 .870 20. .291 1, .00 44, .68 1SG2699
ATOM 2699 C HIS 352 100, .301 39 .033 21. .976 1. .00 44, .68 1SG2700
ATOM 2700 O HIS 352 100. .275 38, .084 22. .756 1. .00 44, .68 1SG2701
ATOM 2701 N GLU 353 101 .429 39 .736 21. .741 1. .00 45, .29 1SG2702
ATOM 2702 CA GLU 353 102. .624 39, .298 22. .403 1, .00 45, .29 1SG2703
ATOM 2703 CB GLU 353 102, .508 39 .250 23. .937 1. .00 45, .29 1SG2704
ATOM 2704 CG GLU 353 102, .535 40 .626 24, .604 1. .00 45, .29 1SG2705
ATOM 2705 CD GLU 353 103, .992 41 .062 24, .709 1. .00 45, .29 1SG2706
ATOM 2706 OEl GLU 353 104 .859 40 .175 24 .930 1 .00 45 .29 1SG2707
ATOM 2707 OE2 GLU 353 104 .257 42 .286 24 .570 1, .00 45 .29 1SG2708
ATOM 2708 C GLU 353 102 .859 37 .913 21 .910 1, .00 45 .29 1SG2709
ATOM 2709 O GLU 353 102 .733 37 .637 20 .718 1, .00 45 .29 1SG2710
ATOM 2710 N ASN 354 103 .250 37 .008 22 .821 1 .00 45 .75 1SG2711
ATOM 2711 CA ASN 354 103 .364 35 .642 22 .417 1, .00 45 .75 1SG2712
ATOM 2712 CB ASN 354 104 .729 35 .034 22 .765 1 .00 45 .75 1SG2713
ATOM 2713 CG ASN 354 105 .781 35 .762 21 .939 1, .00 45 .75 1SG2714
ATOM 2714 ODl ASN 354 105 .504 36 .242 20 .840 1 .00 45 .75 1SG2715
ATOM 2715 ND2 ASN 354 107 .026 35 .845 22 .478 1 .00 45 .75 1SG2716
ATOM 2716 C ASN 354 102 .330 34 .906 23 .207 1, .00 45 .75 1SG2717
ATOM 2717 O ASN 354 102 .656 33 .998 23 .972 1, .00 45 .75 1SG2718
ATOM 2718 N GLN 355 101 .042 35 .271 23 .024 1, .00 44 .42 1SG2719
ATOM 2719 CA GLN 355 100 .010 34 .627 23 .784 1 .00 44 .42 1SG2720
ATOM 2720 CB GLN 355 99 .310 35 .524 24 .824 1, .00 44 .42 1SG2721
ATOM 2721 CG GLN 355 98 .462 36 .635 24, .199 1, .00 44 .42 1SG2722
ATOM 2722 CD GLN 355 97 .579 37 .239 25, .279 1, .00 44, .42 1SG2723
ATOM 2723 OEl GLN 355 96 .549 36 .663 25. .621 1, .00 44, .42 1SG2724
ATOM 2724 NE2 GLN 355 97, .980 38 .417 25, .829 1, .00 44, .42 1SG2725
ATOM 2725 C GLN 355 98, .929 34 .201 22, .848 1, .00 44, .42 1SG2726
ATOM 2726 0 GLN 355 98. .809 34 .701 21, .732 1, .00 44, .42 1SG2727
ATOM 2727 N LEU 356 98. .117 33 .234 23, .308 1. .00 41, .81 1SG2728
ATOM 2728 CA LEU 356 97. .015 32 .698 22, .570 1, .00 41, .81 1SG2729
ATOM 2729 CB LEU 356 96. .946 31 .172 22. .778 1, .00 41, .81 1SG2730
ATOM 2730 CG LEU 356 96, .028 30 .371 21. .842 1. .00 41, .81 1SG2731
ATOM 2731 CD2 LEU 356 95, .568 29 .063 22, .506 1, .00 41, .81 1SG2732
ATOM 2732 CDl LEU 356 96, .700 30 .151 20. .477 1, .00 41, .81 1SG2733
ATOM 2733 C LEU 356 95, .817 33, .275 23, .262 1. .00 41. .81 1SG2734
ATOM 2734 O LEU 356 95, .532 32 .905 24. .400 1. .00 41. .81 1SG2735
ATOM 2735 N GLN 357 95. .090 34, .202 22. .603 1. .00 38. .91 1SG2736
ATOM 2736 CA GLN 357 93. .960 34, .835 23. .231 1. .00 38. .91 1SG2737
ATOM 2737 CB GLN 357 94. .030 36, .370 23. .191 1. .00 38. .91 1SG2738
ATOM 2738 CG GLN 357 92. .839 37, .063 23. .850 1. .00 38. .91 1SG2739
ATOM 2739 CD GLN 357 93. .066 38. .559 23. .711 1. .00 38. .91 1SG2740
ATOM 2740 OEl GLN 357 93. .221 39. .074 22. .604 1. ,00 38. .91 1SG2741
ATOM 2741 NE2 GLN 357 93. .104 39. .276 24. .864 1. ,00 38. .91 1SG2742
ATOM 2742 C GLN 357 92. .741 34. .458 22. .456 1. ,00 38. ,91 1SG2743
ATOM 2743 O GLN 357 92. .818 34. .167 21. .264 1. ,00 38. ,91 1SG2744
ATOM 2744 N MET 358 91. .571 34. .443 23. ,125 1. .00 37. ,69 1SG2745
ATOM 2745 CA MET 358 90. .370 34. .078 22. ,437 1. .00 37. ,69 1SG2746
ATOM 2746 CB MET 358 89. .992 32. .602 22. ,641 1. .00 37. 69 1SG2747
ATOM 2747 CG MET 358 89. .734 32. .248 24. ,109 1. ,00 37. 69 1SG2748
ATOM 2748 SD MET 358 89. .175 30. ,542 24. ,395 1. 00 37. 69 1SG2749
ATOM 2749 CE MET 358 87. .467 30. ,858 23. .866 1. 00 37. 69 1SG2750
ATOM 2750 C MET 358 89. .245 34. ,894 22. .982 1. 00 37. 69 1SG2751
ATOM 2751 O MET 358 89. 366 35. ,536 24. 025 1. 00 37. 69 1SG2752 ATOM 2752 N ALA 359 88.116 34.898 22.247 00 37.11 1SG2753
ATOM 2753 CA ALA 359 86.933 35.583 22.669 00 37.11 1SG2754
ATOM 2754 CB ALA 359 86.649 36.876 21.886 00 37.11 1SG2755
ATOM 2755 C ALA 359 85.804 34.648 22.392 00 37.11 1SG2756
ATOM 2756 O ALA 359 85.850 33.863 21.447 00 37.11 1SG2757
ATOM 2757 N THR 360 84.751 34.694 23.225 00 38.43 1SG2758
ATOM 2758 CA THR 360 83.654 33.811 22.984 00 38.43 1SG2759
ATOM 2759 CB THR 360 83.329 32.928 24.153 1.00 38.43 1SG2760
ATOM 2760 OGl THR 360 84.456 32.135 24.497 1.00 38.43 1SG2761
ATOM 2761 CG2 THR 360 82.144 32.025 23.770 1.00 38.43 1SG2762
ATOM 2762 C THR 360 82.453 34.653 22.723 1.00 38.43 1SG2763
ATOM 2763 O THR 360 82.250 35.688 23.352 1.00 38.43 1SG2764
ATOM 2764 N SER 361 81.636 34.222 21.748 00 40.53 1SG2765
ATOM 2765 CA SER 361 80.398 34.869 21.439 00 40.53 1SG2766
ATOM 2766 CB SER 361 80.384 35.509 20.040 00 40.53 1SG2767
ATOM 2767 OG SER 361 80.869 34.593 19.071 00 40.53 1SG2768
ATOM 2768 C SER 361 79.400 33.769 21.526 00 40.53 1SG2769
ATOM 2769 O SER 361 79.771 32.620 21.308 00 40.53 1SG2770
ATOM 2770 N LEU 362 78.134 34.071 21.897 00 41.40 1SG2771
ATOM 2771 CA LEU 362 77.155 33.027 22.075 00 41.40 1SG2772
ATOM 2772 CB LEU 362 76.639 32.913 23.521 1.00 41.40 1SG2773
ATOM 2773 CG LEU 362 77.699 32.426 24.528 1.00 41.40 1SG2774
ATOM 2774 CD2 LEU 362 78.329 31.098 24.071 1.00 41.40 1SG2775
ATOM 2775 CDl LEU 362 77.120 32.331 25.949 1.00 41.40 1SG2776
ATOM 2776 C LEU 362 75.965 33.303 21.216 1.00 41.40 1SG2777
ATOM 2777 O LEU 362 75.661 34.447 20.891 1.00 41.40 1SG2778
ATOM 2778 N ASP 363 75.280 32.219 20.795 1.00 45.52 1SG2779
ATOM 2779 CA ASP 363 74.097 32.364 19.998 1.00 45.52 1SG2780
ATOM 2780 CB ASP 363 73.949 31.335 18.869 1.00 45.52 1SG2781
ATOM 2781 CG ASP 363 72.993 31.967 17.866 1.00 45.52 1SG2782
ATOM 2782 ODl ASP 363 72.593 33.138 18.110 1.00 45.52 1SG2783
ATOM 2783 OD2 ASP 363 72.650 31.301 16.855 1.00 45.52 1SG2784
ATOM 2784 C ASP 363 72.925 32.235 20.919 1.00 45.52 1SG2785
ATOM 2785 O ASP 363 73.003 32.606 22.088 1.00 45.52 1SG2786
ATOM 2786 N ARG 364 71.791 31.712 20.406 1.00 47.74 1SG2787
ATOM 2787 CA ARG 364 70.604 31.585 21.200 1.00 47.74 1SG2788
ATOM 2788 CB ARG 364 69.409 31.000 20.432 1.00 47.74 1SG2789
ATOM 2789 CG ARG 364 69.018 31.857 19.228 1.00 47.74 1SG2790
ATOM 2790 CD ARG 364 70.042 31.782 18.093 1.00 47.74 1SG2791
ATOM 2791 NE ARG 364 69.588 32.690 17.003 1.00 47.74 1SG2792
ATOM 2792 CZ ARG 364 69.834 32.359 15.703 1.00 47.74 1SG2793
ATOM 2793 NHl ARG 364 70.413 31.159 15.408 1.00 47.74 1SG2794
ATOM 2794 NH2 ARG 364 69.501 33.223 14.700 1.00 47.74 1SG2795
ATOM 2795 C ARG 364 70.921 30.680 22.343 1.00 47.74 1SG2796
ATOM 2796 O ARG 364 71.740 29.770 22.227 1.00 47.74 1SG2797
ATOM 2797 N LEU 365 70.282 30.936 23.500 1.00 52.80 1SG2798
ATOM 2798 CA LEU 365 70.604 30.180 24.669 1.00 52.80 1SG2799
ATOM 2799 CB LEU 365 70.749 31.043 25.933 1.00 52.80 1SG2800
ATOM 2800 CG LEU 365 71.965 31.986 25.894 1.00 52.80 1SG2801
ATOM 2801 CD2 LEU 365 73.264 31.213 25.604 1.00 52.80 1SG2802
ATOM 2802 CDl LEU 365 72.058 32.818 27.180 1.00 52.80 1SG2803
ATOM 2803 C LEU 365 69.551 29.171 24.945 1.00 52.80 1SG2804
ATOM 2804 O LEU 365 68.353 29.446 24.905 1.00 52.80 1SG2805
ATOM 2805 N LEU 366 70.017 27.945 25.227 1.00 58.74 1SG2806
ATOM 2806 CA LEU 366 69.167 26.880 25.636 1.00 58.74 1SG2807
ATOM 2807 CB LEU 366 69.738 25.529 25.212 1.00 58.74 1SG2808
ATOM 2808 CG LEU 366 68.898 24.330 25.653 1.00 58.74 1SG2809 ATOM 2809 CD2 LEU 366 69..694 23..025 25..504 1..00 58..74 1SG2810
ATOM 2810 CDl LEU 366 67. .546 24, .314 24. .928 1. .00 58, .74 1SG2811
ATOM 2811 C LEU 366 69. .293 26, .949 27. .108 1. .00 58. .74 1SG2812
ATOM 2812 O LEU 366 69. .566 25, .966 27, .793 1. .00 58. .74 1SG2813
ATOM 2813 N SER 367 69, .048 28 .159 27, .629 1, .00 58. .12 1SG2814
ATOM 2814 CA SER 367 69, .139 28, .441 29, .021 1. .00 58. .12 1SG2815
ATOM 2815 CB SER 367 69. .004 29, .941 29, .317 1. .00 58. .12 1SG2816
ATOM 2816 OG SER 367 69. .101 30, .176 30, .713 1. .00 58. .12 1SG2817
ATOM 2817 C SER 367 68. .001 27, .760 29 .672 1, .00 58. .12 1SG2818
ATOM 2818 O SER 367 67, .863 27, .766 30, .895 1, .00 58. .12 1SG2819
ATOM 2819 N LEU 368 67. .125 27. .158 28, .860 1. .00 60. .49 1SG2820
ATOM 2820 CA LEU 368 65. .964 26 .684 29 .500 1. .00 60, .49 1SG2821
ATOM 2821 CB LEU 368 64. .688 27 .096 28, .756 1. .00 60, .49 1SG2822
ATOM 2822 CG LEU 368 64. .495 28, .624 28, .681 1. .00 60. .49 1SG2823
ATOM 2823 CD2 LEU 368 63. .091 28, .958 28, .169 1. .00 60. .49 1SG2824
ATOM 2824 CDl LEU 368 65. .598 29 .315 27 .859 1. .00 60. .49 1SG2825
ATOM 2825 C LEU 368 65. .925 25, .213 29, .681 1, .00 60, .49 1SG2826
ATOM 2826 O LEU 368 65, .814 24, .441 28, .727 1. .00 60, .49 1SG2827
ATOM 2827 N SER 369 65, .983 24, .819 30 .961 1. .00 55, .93 1SG2828
ATOM 2828 CA SER 369 65, .806 23 .477 31 .415 1. .00 55, .93 1SG2829
ATOM 2829 CB SER 369 67, .097 22, .639 31, .386 1, .00 55, .93 1SG2830
ATOM 2830 OG SER 369 66, .833 21, .321 31, .845 1. .00 55, .93 1SG2831
ATOM 2831 C SER 369 65, .413 23 .638 3 .846 1. .00 55, .93 1SG2832
ATOM 2832 O SER 369 66, .083 24, .356 33 .589 1. .00 55, .93 1SG2833
ATOM 2833 N ARG 370 64, .316 22, .992 33, .286 1. .00 50, .16 1SG2834
ATOM 2834 CA ARG 370 63, .930 23 .141 34 .661 1. .00 50, .16 1SG2835
ATOM 2835 CB ARG 370 62, .413 23 .130 34 .919 1, .00 50, .16 1SG2836
ATOM 2836 CG ARG 370 61, .687 24, .443 34, .653 1. .00 50, .16 1SG2837
ATOM 2837 CD ARG 370 60. .186 24. .350 34 , .934 1. .00 50. .16 1SG2838
ATOM 2838 NE ARG 370 59. .991 24 .404 36 .411 1, .00 50, .16 1SG2839
ATOM 2839 CZ ARG 370 59, .994 23. .260 37, .160 1. .00 50, .16 1SG2840
ATOM 2840 NHl ARG 370 60. .210 22. .049 36, .571 1. .00 50. .16 1SG2841
ATOM 2841 NH2 ARG 370 59. .775 23 .331 38 .505 1, .00 50, .16 1SG2842
ATOM 2842 C ARG 370 64, .416 21. .943 35, .398 1, .00 50, .16 1SG2843
ATOM 2843 O ARG 370 63, .882 20, .849 35, .222 1. .00 50. .16 1SG2844
ATOM 2844 N LYS 371 65. .466 22, .110 36, .222 1. .00 46. .56 1SG2845
ATOM 2845 CA LYS 371 65, .928 21 .007 37, .009 1, .00 46. .56 1SG2846
ATOM 2846 CB LYS 371 67, .276 21, .294 37, .687 1. .00 46. .56 1SG2847
ATOM 2847 CG LYS 371 67. .828 20, .100 38. .465 1. .00 46. .56 1SG2848
ATOM 2848 CD LYS 371 68. .222 18 .928 37. .565 1. .00 46, .56 1SG2849
ATOM 2849 CE LYS 371 68, .787 17, .725 38, .323 1. .00 46, .56 1SG2850
ATOM 2850 NZ LYS 371 70. .126 18, .050 38. .864 1. .00 46. .56 1SG2851
ATOM 2851 C LYS 371 64. .924 20. .731 38. .087 1. .00 46. .56 1SG2852
ATOM 2852 O LYS 371 64. .449 19. .607 38. .240 1. .00 46. .56 1SG2853
ATOM 2853 N SER 372 64. .558 21. .783 38. .852 1. .00 43. .30 1SG2854
ATOM 2854 CA SER 372 63. .622 21, .648 39. .930 1. .00 43. .30 1SG2855
ATOM 2855 CB SER 372 64. .202 20, .920 41. .155 1. .00 43. .30 1SG2856
ATOM 2856 OG SER 372 64. .530 19, .579 40. .822 1. .00 43. .30 1SG2857
ATOM 2857 C SER 372 63. .269 23. .033 40. .376 1. .00 43. .30 1SG2858
ATOM 2858 O SER 372 63, .997 23. .986 40, .096 1. .00 43. .30 1SG2859
ATOM 2859 N SER 373 62. .132 23. .187 41. .082 1. .00 44. .19 1SG2860
ATOM 2860 CA SER 373 61. .765 24. .499 41. .530 1. ,00 44. .19 1SG2861
ATOM 2861 CB SER 373 60. .782 25. ,205 40. , 579 1. .00 44. ,19 1SG2862
ATOM 2862 OG SER 373 60. .459 26, .496 41. .073 1. .00 44. .19 1SG2863
ATOM 2863 C SER 373 61. ,087 24. .395 42. .858 1. .00 44. .19 1SG2864
ATOM 2864 O SER 373 60. ,226 23. .539 43. .064 1. ,00 44. .19 1SG2865
ATOM 2865 N SER 374 61. .485 25. .263 43. .810 1. .00 45. .86 1SG2866 ATOM 2866 CA SER 374 60.856 25.323 45.099 1.00 45.86 1SG2867
ATOM 2867 CB SER 374 61. .681 26, .113 46. .129 1. .00 45. .86 1SG2868
ATOM 2868 OG SER 374 61 .789 27 .471 45 .727 1 .00 45 .86 1SG2869
ATOM 2869 C SER 374 59 .547 26 .032 44, .925 1 .00 45 .86 1SG2870
ATOM 2870 O SER 374 58 .573 25, .778 45, .632 1. .00 45. .86 1SG2871
ATOM 2871 N ILE 375 59 .529 26 .962 43 .954 1 .00 48 .88 1SG2872
ATOM 2872 CA ILE 375 58 .427 27 .816 43 .609 1 .00 48 .88 1SG2873
ATOM 2873 CB ILE 375 58 .789 28 .804 42 .541 1 .00 48 .88 1SG2874
ATOM 2874 CG2 ILE 375 57 .540 29 .638 42 .232 1 .00 48 .88 1SG2875
ATOM 2875 CGI ILE 375 59. .993 29 .656 42, .963 1. .00 48 .88 1SG2876
ATOM 2876 CDl ILE 375 60 .572 30 .490 41 .820 1 .00 48 .88 1SG2877
ATOM 2877 C ILE 375 57. .295 27 .007 43, .061 1, .00 48 .88 1SG2878
ATOM 2878 O ILE 375 56 .132 27 .350 43 .256 1 .00 48 .88 1SG2879
ATOM 2879 N GLY 376 57 .594 25 .949 42, .290 1, .00 46 .46 1SG2880
ATOM 2880 CA GLY 376 56, .531 25, .169 41, .728 1, .00 46 .46 1SG2881
ATOM 2881 C GLY 376 56 .801 25 .104 40 .263 1 .00 46 .46 1SG2882
ATOM 2882 O GLY 376 57 .722 25 .755 39, .774 1, .00 46 .46 1SG2883
ATOM 2883 N ASN 377 55 .993 24 .321 39 .521 1 .00 44 .74 1SG2884
ATOM 2884 CA ASN 377 56 .209 24 .185 38, .110 1, .00 44 .74 1SG2885
ATOM 2885 CB ASN 377 55, .331 23, .097 37. .465 1, .00 44, .74 1SG2886
ATOM 2886 CG ASN 377 55 .717 22 .986 35 .998 1 .00 44 .74 1SG2887
ATOM 2887 ODl ASN 377 56 .852 22 .649 35. .668 1. .00 44 .74 1SG2888
ATOM 2888 ND2 ASN 377 54 .745 23 .279 35 .091 1 .00 44 .74 1SG2889
ATOM 2889 C ASN 377 55 .878 25 .485 37, .454 1, .00 44 .74 1SG2890
ATOM 2890 O ASN 377 54, .863 26, .108 37, .762 1, .00 44 .74 1SG2891
ATOM 2891 N PHE 378 56 .746 25 .932 36, .524 1, .00 44 .05 1SG2892
ATOM 2892 CA PHE 378 56 .512 27, .181 35, .862 1, .00 44 .05 1SG2893
ATOM 2893 CB PHE 378 57 .240 28 .371 36, .524 1 .00 44 .05 1SG2894
ATOM 2894 CG PHE 378 58 .715 28 .180 36, .385 1, .00 44 .05 1SG2895
ATOM 2895 CDl PHE 378 59 .373 28, .641 35, .268 1, .00 44, .05 1SG2896
ATOM 2896 CD2 PHE 378 59 .446 27 .547 37, .365 1. .00 44 .05 1SG2897
ATOM 2897 CE1 PHE 378 60 .730 28, .472 35. .127 1. .00 44 .05 1SG2898
ATOM 2898 CE2 PHE 378 60 .805 27 .375 37, .229 1, .00 44 .05 1SG2899
ATOM 2899 CZ PHE 378 61 .451 27, .838 36, .108 1. .00 44 .05 1SG2900
ATOM 2900 C PHE 378 57, .013 27, .070 34. .460 1. .00 44, .05 1SG2901
ATOM 2901 O PHE 378 57 .711 26, .125 34, .095 1. .00 44 .05 1SG2902
ATOM 2902 N ASN 379 56, .647 28, .061 33. .628 1. .00 42, .78 1SG2903
ATOM 2903 CA ASN 379 57 .045 28, .054 32. .254 1. .00 42 .78 1SG2904
ATOM 2904 CB ASN 379 56, .235 29, .066 31. .426 1. .00 42, .78 1SG2905
ATOM 2905 CG ASN 379 56, .358 28. .714 29. ,956 1. .00 42. .78 1SG2906
ATOM 2906 ODl ASN 379 57 .098 29, .357 29. .219 1. .00 42. .78 1SG2907
ATOM 2907 ND2 ASN 379 55, .615 27. .662 29. .517 1. .00 42. .78 1SG2908
ATOM 2908 C ASN 379 58, .496 28. .433 32. .218 1. .00 42, .78 1SG2909
ATOM 2909 O ASN 379 58, .883 29. .534 32. .606 1. .00 42. .78 1SG2910
ATOM 2910 N GLU 380 59. .335 27. .506 31. ,722 1. .00 45. .66 1SG2911
ATOM 2911 CA GLU 380 60, .765 27. .633 31. ,655 1. .00 45. .66 1SG2912
ATOM 2912 CB GLU 380 61, .410 26. .377 31. .048 1. .00 45. .66 1SG2913
ATOM 2913 CG GLU 380 61, .108 25. .110 31. .846 1. .00 45. .66 1SG2914
ATOM 2914 CD GLU 380 61. .778 23. .923 31. .167 1. ,00 45. .66 1SG2915
ATOM 2915 OEl GLU 380 62. .838 24. .125 30. 516 1. ,00 45. ,66 1SG2916
ATOM 2916 OE2 GLU 380 61. .232 22. .795 31. .293 1. .00 45. ,66 1SG2917
ATOM 2917 C GLU 380 61. .109 28. .779 30. 750 1. .00 45. ,66 1SG2918
ATOM 2918 O GLU 380 62. .145 29. .423 30. .912 1. .00 45. .66 1SG2919
ATOM 2919 N ARG 381 60. .241 29. .032 29. 756 1. 00 47. .49 1SG2920
ATOM 2920 CA ARG 381 60. .401 30. .017 28. 720 1. 00 47. 49 1SG2921
ATOM 2921 CB ARG 381 59. .277 29. , 934 27. 674 1. 00 47. ,49 1SG2922
ATOM 2922 CG ARG 381 59. ,254 31. .052 26. 631 1. 00 47. 49 1SG2923 ATOM 2923 CD ARG 381 58,.038 30..946 25..707 1..00 47,.49 1SG2924
ATOM 2924 NE ARG 381 57, .967 32. .180 24. .876 1. .00 47, .49 1SG2925
ATOM 2925 CZ ARG 381 56, .780 32. .523 24. ,293 1. .00 47. .49 1SG2926
ATOM 2926 NHl ARG 381 55, .679 31. .737 24. ,480 1. .00 47, .49 1SG2927
ATOM 2927 NH2 ARG 381 56, .689 33. .650 23. .529 1. .00 47, .49 1SG2928
ATOM 2928 C ARG 381 60, .436 31. .415 29. .263 1. .00 47, .49 1SG2929
ATOM 2929 O ARG 381 61, .061 32, .290 28. .667 1. .00 47 .49 1SG2930
ATOM 2930 N GLU 382 59. .757 31, .678 30. .393 1. .00 46 .74 1SG2931
ATOM 2931 CA GLU 382 59 .639 33, .012 30. .920 1. .00 46 .74 1SG2932
ATOM 2932 CB GLU 382 58. .802 33, .056 32. .208 1. .00 46 .74 1SG2933
ATOM 2933 CG GLU 382 57 .362 32, .577 32. .001 1. .00 46 .74 1SG2934
ATOM 2934 CD GLU 382 56. .713 33. .452 30. .937 1. .00 46, .74 1SG2935
ATOM 2935 OEl GLU 382 56, .562 34. .676 31. .192 1. .00 46, .74 1SG2936
ATOM 2936 OE2 GLU 382 56 .362 32. .910 29. .855 1. .00 46, .74 1SG2937
ATOM 2937 C GLU 382 60, .991 33. .596 31. .225 1. .00 46 .74 1SG2938
ATOM 2938 O GLU 382 61 .186 34. .805 31. .106 1. .00 46 .74 1SG2939
ATOM 2939 N LEU 383 61 .943 32, .748 31, .649 1. .00 46 .30 1SG2940
ATOM 2940 CA LEU 383 63 .285 33, .090 32. .045 1. .00 46 .30 1SG2941
ATOM 2941 CB LEU 383 64 .016 31, .906 32. .708 1, .00 46 .30 1SG2942
ATOM 2942 CG LEU 383 63 .351 31, .449 34, .024 1, .00 46 .30 1SG2943
ATOM 2943 CD2 LEU 383 63, .137 32. .633 34. .981 1. .00 46 .30 1SG2944
ATOM 2944 CDl LEU 383 64 .115 30, .287 34. .681 1. .00 46 .30 1SG2945
ATOM 2945 C LEU 383 64, .126 33, .568 30. .893 1. .00 46 .30 1SG2946
ATOM 2946 O LEU 383 65 .154 34, .209 31. .107 1. .00 46 .30 1SG2947
ATOM 2947 N THR 384 63 .747 33, .239 29. .644 1. .00 44 .40 1SG2948
ATOM 2948 CA THR 384 64 .574 33, .505 28. .497 1. .00 44 .40 1SG2949
ATOM 2949 CB THR 384 63 .887 33, .189 27, .200 1. .00 44 .40 1SG2950
ATOM 2950 OGl THR 384 62 .734 34, .003 27, .045 1. .00 44 .40 1SG2951
ATOM 2951 CG2 THR 384 63 .494 31, .706 27. .195 1. .00 44 .40 1SG2952
ATOM 2952 C THR 384 64, .999 34, .942 28. .405 1. .00 44 .40 1SG2953
ATOM 2953 O THR 384 66, .175 35, .214 28. .166 1. .00 44 .40 1SG2954
ATOM 2954 N GLY 385 64, .081 35, .909 28, .581 1. .00 43 .17 1SG2955
ATOM 2955 CA GLY 385 64 .469 37, .283 28, .413 1, .00 43 .17 1SG2956
ATOM 2956 C GLY 385 65 .521 37, .639 29, .415 1. .00 43 .17 1SG2957
ATOM 2957 O GLY 385 66 .483 38, .336 29, .099 1. .00 43 .17 1SG2958
ATOM 2958 N PHE 386 65 .354 37, .186 30, .667 1, .00 45 .24 1SG2959
ATOM 2959 CA PHE 386 66 .300 37, .495 31, .698 1, .00 45 .24 1SG2960
ATOM 2960 CB PHE 386 65 .853 36 .976 33, .074 1. .00 45 .24 1SG2961
ATOM 2961 CG PHE 386 64, .647 37. .760 33. .461 1. .00 45 .24 1SG2962
ATOM 2962 CDl PHE 386 64, .772 38. .938 34. .162 1. .00 45, .24 1SG2963
ATOM 2963 CD2 PHE 386 63, .390 37. .322 33. .112 1. .00 45 .24 1SG2964
ATOM 2964 CE1 PHE 386 63, .659 39. .663 34. .518 1. .00 45, .24 1SG2965
ATOM 2965 CE2 PHE 386 62, .274 38. .043 33, .464 1. .00 45, .24 1SG2966
ATOM 2966 CZ PHE 386 62, .407 39, .215 34, .169 1. .00 45, .24 1SG2967
ATOM 2967 C PHE 386 67, .601 36, .844 31, .361 1. .00 45, .24 1SG2968
ATOM 2968 O PHE 386 68 .666 37, .443 31. .490 1. .00 45 .24 1SG2969
ATOM 2969 N ILE 387 67 .536 35, .587 30. .897 1. .00 48 .59 1SG2970
ATOM 2970 CA ILE 387 68, .707 34. .821 30. .595 1. ,00 48, .59 1SG2971
ATOM 2971 CB ILE 387 68, .368 33. .452 30. .077 1. .00 48, .59 1SG2972
ATOM 2972 CG2 ILE 387 69, .680 32. .795 29. .618 1. ,00 48, .59 1SG2973
ATOM 2973 CGI ILE 387 67, .607 32. .644 31. .142 1. .00 48, .59 1SG2974
ATOM 2974 CDl ILE 387 68, .407 32. .423 32. .426 1. .00 48, .59 1SG2975
ATOM 2975 C ILE 387 69, .484 35. .526 29. .530 1. .00 48, .59 1SG2976
ATOM 2976 O ILE 387 70, .711 35. .576 29. .585 1. .00 48, .59 1SG2977
ATOM 2977 N THR 388 68, .792 36. .085 28. .521 1. ,00 52, .57 1SG2978
ATOM 2978 CA THR 388 69, .490 36. .712 27. .437 1. ,00 52, .57 1SG2979
ATOM 2979 CB THR 388 68. .616 37. ,154 26. .298 1. 00 52. .57 1SG2980 ATOM 2980 OGl THR 388 69.,421 37..462 25.,169 1.00 52.,57 1SG2981
ATOM 2981 CG2 THR 388 67. ,832 38. .404 26. .720 1. 00 52. .57 1SG2982
ATOM 2982 C THR 388 70. ,255 37. ,912 27. 904 1. 00 52. .57 1SG2983
ATOM 2983 O THR 388 71. 332 38. 180 27. .381 1. 00 52. .57 1SG2984
ATOM 2984 N SER 389 69. .708 38. .713 28. .839 1. .00 55. .51 1SG2985
ATOM 2985 CA SER 389 70. ,416 39. .884 29. .282 1. .00 55. .51 1SG2986
ATOM 2986 CB SER 389 69. .527 40. .839 30. .096 1. .00 55. .51 1SG2987
ATOM 2987 OG SER 389 68. .484 41. .348 29. .278 1. .00 55. .51 1SG2988
ATOM 2988 C SER 389 71. .588 39. .535 30. ,152 1. .00 55. .51 1SG2989
ATOM 2989 O SER 389 72. .726 39. .908 29. ,869 1. .00 55. .51 1SG2990
ATOM 2990 N TYR 390 71. .328 38. .775 31. .231 1. ,00 57. ,68 1SG2991
ATOM 2991 CA TYR 390 72. .324 38. .467 32. .216 1. .00 57. .68 1SG2992
ATOM 2992 CB TYR 390 71. ,769 37, .575 33. .339 1. .00 57. .68 1SG2993
ATOM 2993 CG TYR 390 72. .906 36. .726 33. , 789 1. .00 57. .68 1SG2994
ATOM 2994 CDl TYR 390 73. .896 37. .219 34. .603 1. ,00 57. .68 1SG2995
ATOM 2995 CD2 TYR 390 72. .993 35. .424 33. .345 1. ,00 57. .68 1SG2996
ATOM 2996 CE1 TYR 390 74. .937 36. .407 34. .982 1. .00 57. .68 1SG2997
ATOM 2997 CE2 TYR 390 74. .034 34. .610 33. .725 1. .00 57, .68 1SG2998
ATOM 2998 CZ TYR 390 75. .011 35. .105 34. .550 1. .00 57, .68 1SG2999
ATOM 2999 OH TYR 390 76. .086 34. .281 34 , .947 1. .00 57. .68 1SG3000
ATOM 3000 C TYR 390 73. .515 37. .775 31. .651 1. .00 57, .68 1SG3001
ATOM 3001 O TYR 390 74. .646 38, .169 31. .932 1. .00 57. .68 1SG3002
ATOM 3002 N LEU 391 73. .314 36. .730 30. .840 1. .00 56. .49 1SG3003
ATOM 3003 CA LEU 391 74, .457 35 .979 30, .423 1, .00 56. .49 1SG3004
ATOM 3004 CB LEU 391 74, .060 34. .754 29 .574 1, .00 56 .49 1SG3005
ATOM 3005 CG LEU 391 75, .201 33 .758 29, .284 1. .00 56. .49 1SG3006
ATOM 3006 CD2 LEU 391 75, .781 33. .200 30, .593 1, .00 56. .49 1SG3007
ATOM 3007 CDl LEU 391 76, .271 34, .347 28, .353 1. .00 56. .49 1SG3008
ATOM 3008 C LEU 391 75, .388 36, .850 29. .633 1, .00 56. .49 1SG3009
ATOM 3009 O LEU 391 76. .584 36 .900 29, .914 1. .00 56. . 49 1SG3010
ATOM 3010 N GLU 392 74 .864 37 .575 28, .630 1 .00 56 .31 1SG3011
ATOM 3011 CA GLU 392 75. .696 38 .372 27, .772 1, .00 56. .31 1SG3012
ATOM 3012 CB GLU 392 74. .892 38 .988 26, .610 1. .00 56 .31 1SG3013
ATOM 3013 CG GLU 392 75. .724 39 .848 25, .655 1. .00 56, .31 1SG3014
ATOM 3014 CD GLU 392 74, .789 40 .394 24. .583 1. .00 56, .31 1SG3015
ATOM 3015 OEl GLU 392 73. .673 40 .847 24. .952 1. .00 56. .31 1SG3016
ATOM 3016 OE2 GLU 392 75 .176 40 .365 23 .384 1. .00 56 .31 1SG3017
ATOM 3017 C GLU 392 76. .328 39 .501 28 .518 1. .00 56. .31 1SG3018
ATOM 3018 O GLU 392 77 .526 3 .741 28. .386 1. .00 56 .31 1SG3019
ATOM 3019 N GLU 393 75. .544 40. .273 29 .291 1. .00 57. .30 1SG3020
ATOM 3020 CA GLU 393 76 .172 41 .384 29. .936 1. .00 57, .30 1SG3021
ATOM 3021 CB GLU 393 75. .170 42, .401 30. .505 1. .00 57. .30 1SG3022
ATOM 3022 CG GLU 393 75. .847 43 .556 31. .249 1. .00 57. .30 1SG3023
ATOM 3023 CD GLU 393 76 .642 44 .380 30 .246 1. .00 57 .30 1SG3024
ATOM 3024 OEl GLU 393 76 .327 44 .301 29, .028 1. .00 57, .30 1SG3025
ATOM 3025 OE2 GLU 393 77, .578 45 .099 30, .686 1. .00 57 .30 1SG3026
ATOM 3026 C GLU 393 77 .047 40 .962 31, .070 1. .00 57, .30 1SG3027
ATOM 3027 O GLU 393 78, .206 41 .365 31. .144 1. .00 57, .30 1SG3028
ATOM 3028 N ALA 394 76. .482 40 .208 32, .034 1. .00 56, .08 1SG3029
ATOM 3029 CA ALA 394 77 .231 3 .826 33, .198 1 .00 56 .08 1SG3030
ATOM 3030 CB ALA 394 76, .323 39 .425 34 .372 1, .00 56, .08 1SG3031
ATOM 3031 C ALA 394 78 .212 38 .704 33. .019 1. .00 56 .08 1SG3032
ATOM 3032 O ALA 394 79, .379 38 .842 33. .377 1. .00 56. .08 1SG3033
ATOM 3033 N TYR 395 77, .740 37 .550 32, .498 1. .00 55, .61 1SG3034
ATOM 3034 CA TYR 395 78, .534 36 .349 32, .484 1. .00 55. .61 1SG3035
ATOM 3035 CB TYR 395 77, .688 35 .078 32. .306 1. ,00 55. .61 1SG3036
ATOM 3036 CG TYR 395 78, .645 33 .950 3 .461 1. .00 55 .61 1SG3037 ATOM 3037 CDl TYR 395 78,.970 33,.494 33..718 1..00 55..61 1SG3038
ATOM 3038 CD2 TYR 395 79, .240 33, .367 31. .367 1. .00 55. .61 1SG3039
ATOM 3039 CE1 TYR 395 79, .860 32, .460 33, .884 1. .00 55. .61 1SG3040
ATOM 3040 CE2 TYR 395 80, .130 32, .332 31, .527 1. .00 55. .61 1SG3041
ATOM 3041 CZ TYR 395 80, .442 31, .875 32, .786 1. .00 55. .61 1SG3042
ATOM 3042 OH TYR 395 81, .357 30, .813 32, .947 1. .00 55. .61 1SG3043
ATOM 3043 C TYR 395 79, .642 36 .302 31, .481 1. .00 55. .61 1SG3044
ATOM 3044 O TYR 395 80, .782 36, .001 31, .829 1. .00 55. .61 1SG3045
ATOM 3045 N ILE 396 79, .352 36 .606 30, .206 1. .00 51. .02 1SG3046
ATOM 3046 CA ILE 396 80, .359 36, .440 29, .200 1. .00 51. .02 1SG3047
ATOM 3047 CB ILE 396 79, .878 36, .508 27, .766 1. .00 51, .02 1SG3048
ATOM 3048 CG2 ILE 396 78, .942 35 .308 27, .554 1. .00 51. .02 1SG3049
ATOM 3049 CGI ILE 396 79, .246 37 .853 27, .386 1. .00 51, .02 1SG3050
ATOM 3050 CDl ILE 396 79, .029 38 .026 25, .883 1. .00 51, .02 1SG3051
ATOM 3051 C ILE 396 81, .533 37, .341 29, .436 1. .00 51, .02 1SG3052
ATOM 3052 O ILE 396 82. .652 36, .912 29, .160 1. .00 51, .02 1SG3053
ATOM 3053 N PRO 397 81. .406 38 .546 29, .921 1. .00 43, .68 1SG3054
ATOM 3054 CA PRO 397 82. .577 39 .359 30, .073 1. .00 43, .68 1SG3055
ATOM 3055 CD PRO 397 80, .197 39 .349 29, .822 1. .00 43, .68 1SG3056
ATOM 3056 CB PRO 397 82 .076 40 .740 30. .485 1. .00 43, .68 1SG3057
ATOM 3057 CG PRO 397 80 .668 40 .812 29, .866 1. .00 43, .68 1SG3058
ATOM 3058 C PRO 397 83 .592 38 .771 31, .005 1. .00 43, .68 1SG3059
ATOM 3059 O PRO 397 84, .783 38 .984 30. .787 1. .00 43, .68 1SG3060
ATOM 3060 N VAL 398 83, .160 38 .053 32. .058 1. .00 37, .00 1SG3061
ATOM 3061 CA VAL 398 84, .086 37 .496 33. .003 1. .00 37, .00 1SG3062
ATOM 3062 CB VAL 398 83, .387 36 .851 34. .167 1. .00 37, .00 1SG3063
ATOM 3063 CGI VAL 398 84, .437 36 .214 35. .093 1. .00 37, .00 1SG3064
ATOM 3064 CG2 VAL 398 82, .506 37 .909 34, .852 1. .00 37, .00 1SG3065
ATOM 3065 C VAL 398 84, .909 36, .438 32, .338 1. .00 37, .00 1SG3066
ATOM 3066 O VAL 398 86, .128 36 .399 32, .492 1. .00 37, .00 1SG3067
ATOM 3067 N VAL 399 84, .250 35 .546 31 .575 1. .00 32, .01 1SG3068
ATOM 3068 CA VAL 399 84, .924 34 .447 30, .945 1. .00 32, .01 1SG3069
ATOM 3069 CB VAL 399 83, .991 33 .513 30, .238 1. .00 32, .01 1SG3070
ATOM 3070 CGI VAL 399 84, .828 32 .441 29, .519 1. .00 32, .01 1SG3071
ATOM 3071 CG2 VAL 399 83 , .004 32 .942 31, .268 1. .00 32, .01 1SG3072
ATOM 3072 C VAL 399 85, .889 34 .954 29, .929 1. .00 32, .01 1SG3073
ATOM 3073 O VAL 399 87, .007 34 .454 29, .817 1. .00 32, .01 1SG3074
ATOM 3074 N ASN 400 85, .479 35 .978 29, .166 1. .00 30, .26 1SG3075
ATOM 3075 CA ASN 400 86. .295 36, .514 28, .121 1. .00 30, .26 1SG3076
ATOM 3076 CB ASN 400 85. .621 37 .669 27, .358 1. .00 30. .26 1SG3077
ATOM 3077 CG ASN 400 84. .494 37, .089 26, .512 1. .00 30. .26 1SG3078
ATOM 3078 ODl ASN 400 84 , .510 35, .912 26, .156 1. .00 30. .26 1SG3079
ATOM 3079 ND2 ASN 400 83 , .490 37, .940 26, .168 1. ,00 30. .26 1SG3080
ATOM 3080 C ASN 400 87. .550 37, .041 28, .736 1. .00 30. .26 1SG3081
ATOM 3081 O ASN 400 88. .589 37, .081 28, .088 1. .00 30. .26 1SG3082
ATOM 3082 N ASP 401 87. .480 37, .482 30, .006 1. .00 30. .47 1SG3083
ATOM 3083 CA ASP 401 88. .617 38, .053 30. .667 1. .00 30. .47 1SG3084
ATOM 3084 CB ASP 401 88. .294 38, .439 32 , .121 1. .00 30. .47 1SG3085
ATOM 3085 CG ASP 401 89. .450 39, .253 32, .681 1. .00 30. .47 1SG3086
ATOM 3086 ODl ASP 401 90. .398 39, .548 31. .905 1. .00 30. .47 1SG3087
ATOM 3087 OD2 ASP 401 89. .401 39, .590 33. .894 1. .00 30. .47 1SG3088
ATOM 3088 C ASP 401 89. .736 37. .053 30. .704 1. .00 30. .47 1SG3089
ATOM 3089 O ASP 401 90. .877 37, .389 30. .391 1. ,00 30. .47 1SG3090
ATOM 3090 N VAL 402 89. .447 35. .796 31. .097 1. .00 31. .73 1SG3091
ATOM 3091 CA VAL 402 90. .467 34. .785 31. .170 1. .00 31. ,73 1SG3092
ATOM 3092 CB VAL 402 89. .996 33. .515 31. .825 1. .00 31. ,73 1SG3093
ATOM 3093 CGI VAL 402 88. , 927 32. .850 30. .942 1. .00 31. .73 1SG3094 ATOM 3094 CG2 VAL 402 91..223 32..627 32,.088 1..00 31..73 1SG3095
ATOM 3095 C VAL 402 90. .933 34, .453 29, .785 1. .00 31. .73 1SG3096
ATOM 3096 O VAL 402 92, .117 34, .245 29, .538 1. .00 31. .73 1SG3097
ATOM 3097 N LEU 403 89, .994 34, .396 28, .831 1. .00 31. .62 1SG3098
ATOM 3098 CA LEU 403 90, .312 34. .050 27, .475 1. .00 31, .62 1SG3099
ATOM 3099 CB LEU 403 89, .065 34, .076 26, .576 1. .00 31, .62 1SG3100
ATOM 3100 CG LEU 403 87, .954 33, .103 27, .016 1. .00 31 .62 1SG3101
ATOM 3101 CD2 LEU 403 88, .484 31, .668 27, .173 1. .00 31, .62 1SG3102
ATOM 3102 CDl LEU 403 86, .743 33, .187 26, .073 1. .00 31, .62 1SG3103
ATOM 3103 C LEU 403 91. .246 35, .094 26, .952 1. .00 31, .62 1SG3104
ATOM 3104 O LEU 403 92, .190 34 , .796 26. .221 1. .00 31, .62 1SG3105
ATOM 3105 N GLN 404 90, .978 36. .358 27, .315 1. .00 31, .83 1SG3106
ATOM 3106 CA GLN 404 91, .742 37. .498 26, .907 1. .00 31, .83 1SG3107
ATOM 3107 CB GLN 404 91. .138 38. .821 27, .410 1. .00 31, .83 1SG3108
ATOM 3108 CG GLN 404 89, .801 39. .185 26. .765 1. .00 31. .83 1SG3109
ATOM 3109 CD GLN 404 90, .100 39. .785 25. .401 1. .00 31, .83 1SG3110
ATOM 3110 OEl GLN 404 90. .903 40. .710 25, .291 1. .00 31, .83 1SG3111
ATOM 3111 NE2 GLN 404 89. .444 39. .250 24, .337 1. .00 31, .83 1SG3112
ATOM 3112 C GLN 404 93, .117 37. .403 27. .490 1. .00 31, .83 1SG3113
ATOM 3113 O GLN 404 94 , .086 37. .785 26. .838 1. .00 31, .83 1SG3114
ATOM 3114 N VAL 405 93. .253 36. .912 28. .741 1. .00 32, .53 1SG3115
ATOM 3115 CA VAL 405 94. .581 36. .866 29. .288 1. .00 32, .53 1SG3116
ATOM 3116 CB VAL 405 94. .696 36. .388 30. .714 1. .00 32, .53 1SG3117
ATOM 3117 CGI VAL 405 93. .799 37. .270 31, .598 1. .00 32 .53 1SG3118
ATOM 3118 CG2 VAL 405 94. .450 34. .877 30, .806 1, .00 32 .53 1SG3119
ATOM 3119 C VAL 405 95, .357 35. .939 28, .417 1. .00 32 .53 1SG3120
ATOM 3120 O VAL 405 96, .522 36. .185 28, .109 1. .00 32 .53 1SG3121
ATOM 3121 N GLY 406 94, .706 34. .839 27, .993 1. .00 34 .42 1SG3122
ATOM 3122 CA GLY 406 95, .300 33. .942 27, .049 1. .00 34 .42 1SG3123
ATOM 3123 C GLY 406 96, .168 32. .944 27, .739 1, .00 34 .42 1SG3124
ATOM 3124 O GLY 406 96, .246 32. .897 28, .966 1. .00 34, .42 1SG3125
ATOM 3125 N LEU 407 96, .830 32. .103 26, .915 1. .00 39, .79 1SG3126
ATOM 3126 CA LEU 407 97. .726 31. .085 27, .374 1. .00 39, .79 1SG3127
ATOM 3127 CB LEU 407 97. .295 29. .660 26, .989 1. .00 39, .79 1SG3128
ATOM 3128 CG LEU 407 95. .962 29. .226 27, .623 1. .00 39, .79 1SG3129
ATOM 3129 CD2 LEU 407 95. .716 27. .723 27, .426 1. .00 39, .79 1SG3130
ATOM 3130 CDl LEU 407 94. .796 30. .092 27, .118 1. .00 39, .79 1SG3131
ATOM 3131 C LEU 407 99. .047 31. .331 26. .716 1. .00 39, .79 1SG3132
ATOM 3132 o LEU 407 99. .114 31. .878 25. .617 1. .00 39. .79 1SG3133
ATOM 3133 N PRO 408 100. .109 30. .958 27. .378 1. .00 45, .14 1SG3134
ATOM 3134 CA PRO 408 101. .411 31. .164 26. .803 1. .00 45. .14 1SG3135
ATOM 3135 CD PRO 408 100. .138 31. .060 28. .829 1. ,00 45. .14 1SG3136
ATOM 3136 CB PRO 408 102. .404 31. .023 27. .956 1. ,00 45. .14 1SG3137
ATOM 3137 CG PRO 408 101. ,585 31. .433 29. ,192 1. ,00 45. .14 1SG3138
ATOM 3138 C PRO 408 101. ,672 30. .226 25. .665 1. .00 45. .14 1SG3139
ATOM 3139 O PRO 408 101. .222 29. .083 25. .724 1. .00 45. .14 1SG3140
ATOM 3140 N LEU 409 102. .407 30. .685 24. .626 1. .00 51. .23 1SG3141
ATOM 3141 CA LEU 409 102. .729 29. .838 23, .510 1. .00 51. .23 1SG3142
ATOM 3142 CB LEU 409 102. .637 30. .514 22, .128 1. .00 51. .23 1SG3143
ATOM 3143 CG LEU 409 101. ,196 30. .759 21, .645 1. .00 51. .23 1SG3144
ATOM 3144 CD2 LEU 409 101. .167 31. .266 20. .195 1. .00 51. .23 1SG3145
ATOM 3145 CDl LEU 409 100. .436 31. .680 22. .604 1. ,00 51. .23 1SG3146
ATOM 3146 C LEU 409 104. ,141 29. .377 23. .677 1. ,00 51. .23 1SG3147
ATOM 3147 O LEU 409 104. .966 30. .063 24. .277 1. ,00 51. .23 1SG3148
ATOM 3148 N PRO 410 104. .425 28. .178 23. .247 1. ,00 55. ,97 1SG3149
ATOM 3149 CA PRO 410 105. 759 27. .648 23. ,338 1. .00 55. ,97 1SG3150
ATOM 3150 CD PRO 410 103. 606 27. .460 22. .285 1. .00 55. .97 1SG3151 ATOM 3151 CB PRO 410 105,.670 26..252 22.,729 1.,00 55.,97 1SG3152
ATOM 3152 CG PRO 410 104. .552 26. .408 21. .677 1. .00 55. .97 1SG3153
ATOM 3153 C PRO 410 106. .711 28. .507 22. ,567 1. .00 55. ,97 1SG3154
ATOM 3154 O PRO 410 106. .978 28. .183 21. .412 1. .00 55. .97 1SG3155
ATOM 3155 N ASP 411 107. .302 29. .544 23. ,190 1. ,00 56. .76 1SG3156
ATOM 3156 CA ASP 411 108, .207 30. .385 22. ,463 1. ,00 56. .76 1SG3157
ATOM 3157 CB ASP 411 107. .727 31. .841 22. .351 1. .00 56. .76 1SG3158
ATOM 3158 CG ASP 411 107 .664 32, .412 23. .762 1, .00 56. .76 1SG3159
ATOM 3159 ODl ASP 411 107, .124 31, .713 24. .661 1. .00 56. .76 1SG3160
ATOM 3160 OD2 ASP 411 108 .154 33. .556 23. .959 1. .00 56. .76 1SG3161
ATOM 3161 C ASP 411 109, .499 30. .410 23. .211 1. .00 56. .76 1SG3162
ATOM 3162 O ASP 411 109 .514 30. .477 24. .439 1. .00 56. .76 1SG3163
ATOM 3163 N PHE 412 110, .621 30. .366 22. .468 1. .00 57. .75 1SG3164
ATOM 3164 CA PHE 412 111, .942 30. .392 23. ,029 1. .00 57. .75 1SG3165
ATOM 3165 CB PHE 412 113 .061 30. .267 21, .981 1. .00 57. .75 1SG3166
ATOM 3166 CG PHE 412 112 .814 29. .064 21, .141 1. .00 57. .75 1SG3167
ATOM 3167 CDl PHE 412 113, .207 27. .808 21, .543 1. .00 57, .75 1SG3168
ATOM 3168 CD2 PHE 412 112 .184 29. .212 19. .926 1. .00 57. .75 1SG3169
ATOM 3169 CE1 PHE 412 112, .965 26. .718 20. .739 1, .00 57, .75 1SG3170
ATOM 3170 CE2 PHE 412 111 .941 28, .126 19. .121 1. .00 57. .75 1SG3171
ATOM 3171 CZ PHE 412 112, .332 26. .875 19. .529 1, .00 57. .75 1SG3172
ATOM 3172 C PHE 412 112 .094 31. .766 23. .597 1. .00 57. .75 1SG3173
ATOM 3173 O PHE 412 111 .251 32, .631 23, .369 1, .00 57 .75 1SG3174
ATOM 3174 N LEU 413 113 .163 31 .992 24, .382 1, .00 55. .57 1SG3175
ATOM 3175 CA LEU 413 113 .376 33, .261 25, .019 1, .00 55 .57 1SG3176
ATOM 3176 CB LEU 413 114 .504 33 .221 26, .068 1, .00 55. .57 1SG3177
ATOM 3177 CG LEU 413 114 .760 34, .565 26, .775 1, .00 55. .57 1SG3178
ATOM 3178 CD2 LEU 413 116, .101 34, .561 27, .528 1. .00 55, .57 1SG3179
ATOM 3179 CDl LEU 413 113, .572 34, .957 27. .668 1. .00 55. .57 1SG3180
ATOM 3180 C LEU 413 113 .751 34 .296 23 .999 1. .00 55. .57 1SG3181
ATOM 3181 0 LEU 413 114 .325 33 .995 22 .952 1, .00 55 .57 1SG3182
ATOM 3182 N ALA 414 113, .411 35 .564 24 .314 1, .00 50. .77 1SG3183
ATOM 3183 CA ALA 414 113 .720 36, .734 23. .540 1. .00 50. .77 1SG3184
ATOM 3184 CB ALA 414 115, .227 37 .041 23 .492 1, .00 50, .77 1SG3185
ATOM 3185 C ALA 414 113 .218 36, .651 22. .130 1. .00 50, .77 1SG3186
ATOM 3186 O ALA 414 113, .904 37 .087 21. .206 1. .00 50, .77 1SG3187
ATOM 3187 N MET 415 111 .999 36, .118 21, .913 1. .00 47, .00 1SG3188
ATOM 3188 CA MET 415 111 .483 36 .104 20 .572 1 .00 47 .00 1SG3189
ATOM 3189 CB MET 415 111 .377 34 .703 19 .948 1, .00 47, .00 1SG3190
ATOM 3190 CG MET 415 110, .335 33. .801 20 .607 1. .00 47, .00 1SG3191
ATOM 3191 SD MET 415 110 .155 32 .188 19, .793 1, .00 47, .00 1SG3192
ATOM 3192 CE MET 415 109, .553 32, .896 18 .233 1, .00 47, .00 1SG3193
ATOM 3193 C MET 415 110 .109 36, .697 20, .602 1. .00 47. .00 1SG3194
ATOM 3194 0 MET 415 109, .427 36, .647 21, .623 1, .00 47. .00 1SG3195
ATOM 3195 N ASN 416 109 .678 37 .301 19 .475 1, .00 42. .16 1SG3196
ATOM 3196 CA ASN 416 108 .380 37 .913 19 .423 1 .00 42. .16 1SG3197
ATOM 3197 CB ASN 416 108, .442 39 .443 19 .263 1, .00 42, .16 1SG3198
ATOM 3198 CG ASN 416 109, .209 40 .038 20, .437 1. .00 42, .16 1SG3199
ATOM 3199 ODl ASN 416 110. .148 40 .811 20 .246 1, .00 42. .16 1SG3200
ATOM 3200 ND2 ASN 416 108. .803 39, .676 21, .683 1. .00 42. .16 1SG3201
ATOM 3201 C ASN 416 107, .708 37 .405 18 .186 1. .00 42. .16 1SG3202
ATOM 3202 0 ASN 416 108, .374 37, .074 17. .207 1. .00 42. .16 1SG3203
ATOM 3203 N TYR 417 106, .360 37 .332 18 .196 1. .00 40, .23 1SG3204
ATOM 3204 CA TYR 417 105 .649 36 .885 17 .029 1. .00 40. .23 1SG3205
ATOM 3205 CB TYR 417 104, .669 35, .717 17 .258 1. .00 40. .23 1SG3206
ATOM 3206 CG TYR 417 105 .416 34 .428 17. .237 1. .00 40. .23 1SG3207
ATOM 3207 CDl TYR 417 105, .774 33. .888 16 .024 1. .00 40. .23 1SG3208 s O SS S 3 IS
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ATOM 3265 CGI ILE 424 88.531 30,.481 12..568 1,.00 51.40 1SG3266
ATOM 3266 CDl ILE 424 87 .223 31, .237 12. .333 1, .00 51 .40 1SG3267
ATOM 3267 C ILE 424 90 .728 28, .481 12. .151 1, .00 51 .40 1SG3268
ATOM 3268 O ILE 424 90. .945 28, .261 13, .342 1, .00 51. .40 1SG3269
ATOM 3269 N VAL 425 90 .563 27 .511 11 .244 1 .00 50 .62 1SG3270
ATOM 3270 CA VAL 425 90 .596 26, .186 11, .751 1, .00 50. .62 1SG3271
ATOM 3271 CB VAL 425 89 .293 25 .725 12 .390 1 .00 50 .62 1SG3272
ATOM 3272 CGI VAL 425 89 .485 24 .350 13 .045 1 .00 50 .62 1SG3273
ATOM 3273 CG2 VAL 425 88 .684 26, .753 13, .355 1, .00 50. .62 1SG3274
ATOM 3274 C VAL 425 90 .808 25 .290 10 .576 1 .00 50 .62 1SG3275
ATOM 3275 O VAL 425 90 .618 25. .678 9, .423 1, .00 50 .62 1SG3276
ATOM 3276 N GLU 426 91 .231 24 .052 10 .870 1 .00 45 .52 1SG3277
ATOM 3277 CA GLU 426 91 .370 23 .006 9, ,914 1 .00 45 .52 1SG3278
ATOM 3278 CB GLU 426 92 .811 22 .494 9 .739 1 .00 45 .52 1SG3279
ATOM 3279 CG GLU 426 92 .977 21, .503 8 .583 1 .00 45 .52 1SG3280
ATOM 3280 CD GLU 426 9 .439 21, .078 8, .528 1, .00 45 .52 1SG3281
ATOM 3281 OEl GLU 426 95 .167 21 .356 9 .518 1 .00 45 .52 1SG3282
ATOM 3282 OE2 GLU 426 94 .848 20. .477 7 .499 1, .00 45 .52 1SG3283
ATOM 3283 C GLU 426 90 .572 21 .908 10 .527 1 .00 45 .52 1SG3284
ATOM 3284 O GLU 426 89 .985 22 .087 11 .592 1 .00 45 .52 1SG3285
ATOM 3285 N LEU 427 90, .480 20, .743 9. .876 1. .00 41. .47 1SG3286
ATOM 3286 CA LEU 427 89 .680 19 .754 10 .522 1 .00 41 .47 1SG3287
ATOM 3287 CB LEU 427 89 .382 18, .542 9, .614 1, .00 41 .47 1SG3288
ATOM 3288 CG LEU 427 88 .417 17 .493 10 .205 1 .00 41 .47 1SG3289
ATOM 3289 CD2 LEU 427 87, .064 18, .134 10, .549 1, .00 41 .47 1SG3290
ATOM 3290 CDl LEU 427 89 .031 16 .724 11 .385 1 .00 41 .47 1SG3291
ATOM 3291 C LEU 427 90 .432 19, .289 11, .730 1, .00 41 .47 1SG3292
ATOM 3292 O LEU 427 91, .551 18. .789 11, .627 1, .00 41, .47 1SG3293
ATOM 3293 N GLY 428 89 .817 19. .457 12, .918 1, .00 39 .05 1SG3294
ATOM 3294 CA GLY 428 90. .365 18 , .958 14, .146 1, .00 39, .05 1SG3295
ATOM 3295 C GLY 428 91 .642 19. .642 14 .524 1, .00 39 .05 1SG3296
ATOM 3296 O GLY 428 92 .512 18. .998 15, .103 1, .00 39 .05 1SG3297
ATOM 3297 N GLY 429 91, .816 20, .946 14, .224 1, .00 36 .81 1SG3298
ATOM 3298 CA GLY 429 93 .032 21, .590 14, .649 1, .00 36 .81 1SG3299
ATOM 3299 C GLY 429 93, .048 22. .984 14, .098 1. .00 36, .81 1SG3300
ATOM 3300 O GLY 429 92 .389 23, .276 13, .102 1, .00 36 .81 1SG3301
ATOM 3301 N ILE 430 93, .832 23. .885 14 , .729 1, .00 38, .57 1SG3302
ATOM 3302 CA ILE 430 9 .887 25. .244 14. .272 1, .00 38 .57 1SG3303
ATOM 3303 CB ILE 430 93, .455 26. .243 15. .309 1. .00 38, .57 1SG3304
ATOM 3304 CG2 ILE 430 91, .976 25. , 972 15. .629 1. .00 38. .57 1SG3305
ATOM 3305 CGI ILE 430 94, .374 26. .206 16. .540 1. .00 38. .57 1SG3306
ATOM 3306 CDl ILE 430 94. .139 27. .375 17. .497 1. .00 38. .57 1SG3307
ATOM 3307 C ILE 430 95. .285 25. .562 13. .847 1. .00 38. .57 1SG3308
ATOM 3308 O ILE 430 96. .255 25. .159 14. .487 1. .00 38. .57 1SG3309
ATOM 3309 N MET 431 95. .415 26. .298 12. .723 1. .00 38. .87 1SG3310
ATOM 3310 CA MET 431 96. .709 26. .603 12. .183 1. .00 38. .87 1SG3311
ATOM 3311 CB MET 431 96. .739 26. ,611 10. .645 1. .00 38. ,87 1SG3312
ATOM 3312 CG MET 431 96. .339 25. .285 9. .998 1. .00 38. .87 1SG3313
ATOM 3313 SD MET 431 96. .369 25. ,320 8. .181 1. ,00 38. ,87 1SG3314
ATOM 3314 CE MET 431 95. .377 23. ,815 7. .968 1. .00 38. .87 1SG3315
ATOM 3315 C MET 431 97. .073 27. ,992 12. .591 1. .00 38. .87 1SG3316
ATOM 3316 0 MET 431 96. .285 28. .923 12. .427 1. .00 38. .87 1SG3317
ATOM 3317 N GLU 432 98. .292 28. .163 13. .144 1. .00 38. ,15 1SG3318
ATOM 3318 CA GLU 432 98. ,706 29. 479 13. .525 1. 00 38. ,15 1SG3319
ATOM 3319 CB GLU 432 98. ,816 29. .649 15. .050 1. .00 38. ,15 1SG3320
ATOM 3320 CG GLU 432 99. ,250 31. 049 15. ,485 1. 00 38. ,15 1SG3321
ATOM 3321 CD GLU 432 99. ,126 31. .118 17. .001 1. .00 38. .15 1SG3322
Figure imgf000662_0001
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tototow totomtototototototototowtotototototototototototototototototototototototototototototototototototototototo Ω Ω Ω Ω Ώ Ω Ω Ω Ώ Ώ Ώ Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ
ATOM 133 O GLN 18 122.,436 33.,165 14.,151 1.,00 26.,25 ISG 134
ATOM 134 N SER 19 121. ,544 33. .724 12. .163 1. ,00 26. ,89 ISG 135
ATOM 135 CA SER 19 122. .813 34. .129 11. .627 1. .00 26. .89 ISG 136
ATOM 136 CB SER 19 122. .695 34. .754 10. .229 1. .00 26. ,89 ISG 137
ATOM 137 OG SER 19 122. .146 33. .811 9. .324 1. .00 26. .89 ISG 138
ATOM 138 C SER 19 123. .387 35, .181 12, .517 1, .00 26. .89 ISG 139
ATOM 139 0 SER 19 124. .571 35. .148 12. .848 1. .00 26. .89 ISG 140
ATOM 140 N ALA 20 122. .544 36. .133 12. .953 1. .00 27. .62 ISG 141
ATOM 141 CA ALA 20 123. ,025 37. .210 13. .763 1. .00 27. .62 ISG 142
ATOM 142 CB ALA 20 121. .911 38. .182 14 , .185 1. .00 27. .62 ISG 143
ATOM 143 C ALA 20 123. .598 36, .616 15, .006 1. .00 27. .62 ISG 144
ATOM 144 0 ALA 20 124. .659 37. .026 15, .472 1. .00 27. .62 ISG 145
ATOM 145 N MET 21 122. .904 35. .612 15, .566 1. .00 30. .30 ISG 146
ATOM 146 CA MET 21 123. .354 34. .970 16, .764 1, .00 30. .30 ISG 147
ATOM 147 CB MET 21 122. .359 33. .914 17, .274 1. .00 30. .30 ISG 148
ATOM 148 CG MET 21 122. .787 33, .239 18, .578 1, .00 30. .30 ISG 149
ATOM 149 SD MET 21 121. .619 31, .989 19, .193 1. .00 30. .30 ISG 150
ATOM 150 CE MET 21 120. .359 33 , .189 19, .714 1. .00 30. .30 ISG 151
ATOM 151 C MET 21 124. .646 34, .276 16 .468 1, .00 30. .30 ISG 152
ATOM 152 O MET 21 125. .545 34, .239 17, .305 1. .00 30. .30 ISG 153
ATOM 153 N ASP 22 124, .751 33 .699 15, .256 1. .00 31, .32 ISG 154
ATOM 154 CA ASP 22 125, .888 32 .940 14 .811 1 .00 31 .32 ISG 155
ATOM 155 CB ASP 22 125. .656 32, .340 13, .410 1. .00 31, .32 ISG 156
ATOM 156 CG ASP 22 126. .808 31 .409 13 .056 1. .00 31, .32 ISG 157
ATOM 157 ODl ASP 22 127. .689 31, .184 13, .928 1. .00 31, .32 ISG 158
ATOM 158 OD2 ASP 22 126. .820 30, .910 11, .899 1. .00 31, .32 ISG 159
ATOM 159 C ASP 22 127, .099 33 .818 14 .717 1 .00 31 .32 ISG 160
ATOM 160 0 ASP 22 128. .206 33. .400 15, .051 1, .00 31, .32 ISG 161
ATOM 161 N GLU 23 126. .919 35 .072 14 .269 1. .00 32 .32 ISG 162
ATOM 162 CA GLU 23 128 .035 35 .943 14 .034 1 .00 32 .32 ISG 163
ATOM 163 CB GLU 23 127. .606 37 .323 13 .514 1. .00 32 .32 ISG 164
ATOM 164 CG GLU 23 128. .783 38 .263 13 .258 1 .00 32 .32 ISG 165
ATOM 165 CD GLU 23 128, .221 39, .598 12, .794 1, .00 32, .32 ISG 166
ATOM 166 OEl GLU 23 126, .973 39 .700 12, .652 1. .00 32 .32 ISG 167
ATOM 167 OE2 GLU 23 129 .034 40 .537 12 .581 1 .00 32 .32 ISG 168
ATOM 168 C GLU 23 128, .802 36 .169 15, .302 1. .00 32, .32 ISG 169
ATOM 169 0 GLU 23 130, .032 36 .168 15 .300 1. .00 32 .32 ISG 170
ATOM 170 N SER 24 128 .108 36 .359 16 .433 1 .00 33 .76 ISG 171
ATOM 171 CA SER 24 128, .810 36 .649 17 .650 1, .00 33, .76 ISG 172
ATOM 172 CB SER 24 127, .867 36 .828 18 .851 1 .00 33 .76 ISG 173
ATOM 173 OG SER 24 127, .190 35 .611 19, .125 1. .00 33, .76 ISG 174
ATOM 174 C SER 24 129, .732 35 .515 17 .970 1, .00 33, .76 ISG 175
ATOM 175 0 SER 24 130 .883 35 .728 18 .347 1 .00 33 .76 ISG 176
ATOM 176 N HIS 25 129. .250 34, .271 17, .808 1, .00 35, .15 ISG 177
ATOM 177 CA HIS 25 130. .027 33 .113 18 .140 1, .00 35, .15 ISG 178
ATOM 178 NDl HIS 25 126 .867 32 .290 18 .726 1 .00 35 .15 ISG 179
ATOM 179 CG HIS 25 128. .087 31 .680 18 .911 1, .00 35, .15 ISG 180
ATOM 180 CB HIS 25 129. .242 31 .802 17 .962 1 .00 35, .15 ISG 181
ATOM 181 NE2 HIS 25 126. .727 31, .160 20 .636 1, .00 35. .15 ISG 182
ATOM 182 CD2 -HIS 25 127, .984 30 .994 20 .083 1, .00 35. .15 ISG 183
ATOM 183 CE1 HIS 25 126, .092 31 .946 19 .786 1 .00 35 .15 ISG 184
ATOM 184 C HIS 25 131, .230 33 .043 17, .253 1, .00 35, .15 ISG 185
ATOM 185 0 HIS 25 132, .323 32 .709 17 .709 1, .00 35, .15 ISG 186
ATOM 186 N ILE 26 131. .066 33 .357 15 .954 1 .00 38 .20 ISG 187
ATOM 187 CA ILE 26 132, .164 33 .232 15 .039 1, .00 38. .20 ISG 188
ATOM 188 CB ILE 26 131, .789 33 .382 13 .589 1, .00 38, .20 ISG 189
ATOM 189 CG2 ILE 26 131. .356 34, .824 13, .320 1. .00 38. .20 ISG 190 ATOM 190 CGI ILE 26 132,.946 32..903 12..696 1..00 38..20 ISG 191
ATOM 191 CDl ILE 26 132. .548 32. .718 11. .232 1. 00 38. .20 ISG 192
ATOM 192 C ILE 26 133. .259 34. .192 15. .402 1. .00 38. .20 ISG 193
ATOM 193 O ILE 26 134. .437 33. .859 15. .290 1. ,00 38. .20 ISG 194
ATOM 194 N LEU 27 132. .906 35. .409 15. .857 1. ,00 40. .92 ISG 195
ATOM 195 CA LEU 27 133. .880 36. .407 16. .223 1. .00 40. .92 ISG 196
ATOM 196 CB LEU 27 133. .248 37, .720 16. .721 1. .00 40. .92 ISG 197
ATOM 197 CG LEU 27 132. .718 38. .633 15. .604 1. .00 40. .92 ISG 198
ATOM 198 CD2 LEU 27 133, .859 39. .024 14 , .650 1. .00 40, .92 ISG 199
ATOM 199 CDl LEU 27 132, .023 39. .876 16. .183 1. .00 40, .92 ISG 200
ATOM 200 C LEU 27 134, .742 35. .893 17. .339 1. .00 40, .92 ISG 201
ATOM 201 O LEU 27 135. .914 36. .248 17, .440 1. .00 40, .92 ISG 202
ATOM 202 N GLU 28 134, .177 35. .048 18, .215 1. ,00 42, .95 ISG 203
ATOM 203 CA GLU 28 134, .832 34, .535 19. .388 1. .00 42. .95 ISG 204
ATOM 204 CB GLU 28 133, .904 33, .653 20, .241 1. .00 42 .95 ISG 205
ATOM 205 CG GLU 28 132, .755 34. .427 20. .887 1. .00 42, .95 ISG 206
ATOM 206 CD GLU 28 133, .340 35. .295 21. .991 1. .00 42, .95 ISG 207
ATOM 207 OEl GLU 28 134 .573 35, .197 22. .229 1, .00 42 .95 ISG 208
ATOM 208 OE2 GLU 28 132, .562 36, .067 22. .612 1. .00 42, .95 ISG 209
ATOM 209 C GLU 28 136 .032 33, .700 19, .041 1, .00 42 .95 ISG 210
ATOM 210 O GLU 28 136 .954 33 .586 19 .845 1. .00 42 .95 ISG 211
ATOM 211 N LYS 29 136 .047 33, .074 17, .851 1. .00 43 .10 ISG 212
ATOM 212 CA LYS 29 137 .079 32, .151 17, .463 1, ,00 43 .10 ISG 213
ATOM 213 CB LYS 29 136 .982 31 .753 15 .980 1. .00 43 .10 ISG 214
ATOM 214 CG LYS 29 137 .139 32, .928 15, .014 1. .00 43 .10 ISG 215
ATOM 215 CD LYS 29 137 .329 32, .496 13, .559 1, .00 43 .10 ISG 216
ATOM 216 CE LYS 29 137, .483 33. .668 12 , .588 1. .00 43 .10 ISG 217
ATOM 217 NZ LYS 29 136 .245 34, .477 12, .570 1. .00 43 .10 ISG 218
ATOM 218 C LYS 29 138 .444 32, .717 17, .712 1, .00 43 .10 ISG 219
ATOM 219 O LYS 29 138 .686 33. .914 17. .568 1. .00 43 .10 ISG 220
ATOM 220 N MET 30 139 .385 31. .840 18. .122 1. .00 42 .60 ISG 221
ATOM 221 CA MET 30 140 .713 32 .294 18, .407 1, .00 42 .60 ISG 222
ATOM 222 CB MET 30 141 .221 31, .899 19. .802 1, .00 42, ,60 ISG 223
ATOM 223 CG MET 30 142 .559 32, .552 20. .149 1, .00 42 .60 ISG 224
ATOM 224 SD MET 30 143 .235 32, .081 21. .769 1, .00 42 .60 ISG 225
ATOM 225 CE MET 30 141 .912 32, .865 22. .733 1, .00 42 .60 ISG 226
ATOM 226 C MET 30 141 .649 31, .674 17. .420 1, .00 42 .60 ISG 227
ATOM 227 O MET 30 141, .481 30, .522 17, .022 1, .00 42 .60 ISG 228
ATOM 228 N ALA 31 142 .667 32. .449 16. .998 1, .00 43 .85 ISG 229
ATOM 229 CA ALA 31 143 .646 31. .981 16. .060 1, .00 43 .85 ISG 230
ATOM 230 CB ALA 31 143, .707 32. .812 14. .768 1. .00 43. .85 ISG 231
ATOM 231 C ALA 31 144 .991 32. .091 16. .718 1, .00 43 .85 ISG 232
ATOM 232 O ALA 31 145 .215 32. .951 17, .569 1, .00 43 .85 ISG 233
ATOM 233 N ALA 32 145, .919 31. .202 16. .310 1. .00 47, .92 ISG 234
ATOM 234 CA ALA 32 147 .242 31. .061 16. .859 1. .00 47 .92 ISG 235
ATOM 235 CB ALA 32 147 .902 29, .713 16. .518 1. .00 47 .92 ISG 236
ATOM 236 C ALA 32 148, .155 32. .141 16. .363 1. .00 47, .92 ISG 237
ATOM 237 O ALA 32 147 .759 33. .020 15. .599 1, .00 47, .92 ISG 238
ATOM 238 N GLU 33 149 .418 32. .099 16. .846 1, .00 55 .56 ISG 239
ATOM 239 CA GLU 33 150, .417 33. .079 16. .528 1. .00 55, .56 ISG 240
ATOM 240 CB GLU 33 150 .953 33. .811 17. .770 1. .00 55, .56 ISG 241
ATOM 241 CG GLU 33 149, .856 34. .423 18. .656 1. .00 55, .56 ISG 242
ATOM 242 CD GLU 33 148, .884 35. .293 17. .856 1. .00 55, .56 ISG 243
ATOM 243 OEl GLU 33 149, .048 35. .436 16. .615 1. .00 55, .56 ISG 244
ATOM 244 OE2 GLU 33 147, .943 35. .829 18. .499 1. .00 55, .56 ISG 245
ATOM 245 C GLU 33 151, .579 32. .399 15. .833 1. .00 55. .56 ISG 246
ATOM 246 O GLU 33 151, .385 31. .661 14. .871 1. .00 55. .56 ISG 247 ATOM 247 N ALA 34 152.820 32.635 16.326 1,.00 62.97 ISG 248
ATOM 248 CA ALA 34 154 .099 32 .239 15 .763 1 .00 62 .97 ISG 249
ATOM 249 CB ALA 34 155 .277 32 .586 16 .689 1, .00 62 .97 ISG 250
ATOM 250 C ALA 34 154 .191 30 .764 15 .486 1 .00 62 .97 ISG 251
ATOM 251 O ALA 34 153 .416 29 .975 16 .013 1 .00 62 .97 ISG 252
ATOM 252 N GLY 35 155 .129 30 .366 14 .587 1 .00 65 .86 ISG 253
ATOM 253 CA GLY 35 155 .368 28 .974 14 .264 1, .00 65 .86 ISG 254
ATOM 254 C GLY 35 156 .400 28 .907 13 .175 1 .00 65 .86 ISG 255
ATOM 255 O GLY 35 156 .340 29 .691 12 .236 1 .00 65 .86 ISG 256
ATOM 256 N LYS 36 157 .338 27, .930 13 .231 1, .00 64. .40 ISG 257
ATOM 257 CA LYS 36 158 .439 27, .927 12 .296 1, .00 64. .40 ISG 258
ATOM 258 CB LYS 36 159 .813 27 .987 12 .987 1 .00 64 .40 ISG 259
ATOM 259 CG LYS 36 161 .012 27 .939 12 .033 1 .00 64 .40 ISG 260
ATOM 260 CD LYS 36 161 .131 29 .146 11 .102 1 .00 64 .40 ISG 261
ATOM 261 CE LYS 36 162 .440 29 .193 10 .314 1 .00 64 .40 ISG 262
ATOM 262 NZ LYS 36 163 .555 29 .565 11 .212 1 .00 64 .40 ISG 263
ATOM 263 C LYS 36 158 .493 26 .698 11 .446 1, .00 64 .40 ISG 264
ATOM 264 O LYS 36 158 .095 25 .606 11 .849 1 .00 64 .40 ISG 265
ATOM 265 N LYS 37 158 .992 26 .889 10 .204 1, .00 60 .35 ISG 266
ATOM 266 CA LYS 37 159 .280 25 .813 9 .308 1 .00 60 .35 ISG 267
ATOM 267 CB LYS 37 158 .050 25 .103 8 .723 1, .00 60 .35 ISG 268
ATOM 268 CG LYS 37 158 .409 23 .684 8 .277 1, .00 60 .35 ISG 269
ATOM 269 CD LYS 37 157, .219 22, .727 8 .218 1, .00 60 .35 ISG 270
ATOM 270 CE LYS 37 157, .640 21, .260 8 .103 1, .00 60. .35 ISG 271
ATOM 271 NZ LYS 37 156, .509 20, .378 8 .467 1, .00 60. .35 ISG 272
ATOM 272 C LYS 37 160, .150 26, .349 8, .211 1, .00 60. .35 ISG 273
ATOM 273 O LYS 37 159 .989 27 .482 7 .757 1 .00 60 .35 ISG 274
ATOM 274 N GLN 38 161 .099 25 .516 7. .748 1 .00 57 .50 ISG 275
ATOM 275 CA GLN 38 162 .103 25 .911 6 .800 1 .00 57 .50 ISG 276
ATOM 276 CB GLN 38 163 .090 24 .778 6 .478 1, .00 57 .50 ISG 277
ATOM 277 CG GLN 38 163 .951 24, .342 7 .663 1, .00 57 .50 ISG 278
ATOM 278 CD GLN 38 164, .833 23, .201 7 .179 1, .00 57. .50 ISG 279
ATOM 279 OEl GLN 38 164, .470 22, .479 6 .251 1, .00 57. .50 ISG 280
ATOM 280 NE2 GLN 38 166, .020 23, .029 7, .819 1, .00 57, .50 ISG 281
ATOM 281 C GLN 38 161, .503 26, .329 5, .493 1. .00 57, .50 ISG 282
ATOM 282 O GLN 38 161, .956 27. .311 4, .908 1, .00 57, .50 ISG 283
ATOM 283 N PRO 39 160. .515 25. .641 4, .996 1. .00 63. .96 ISG 284
ATOM 284 CA PRO 39 159. .997 25. .988 3 , .704 1. .00 63. .96 ISG 285
ATOM 285 CD PRO 39 160. .349 24. .224 5, .260 1. .00 63. .96 ISG 286
ATOM 286 CB PRO 39 159. .079 24. .835 3. .286 1. .00 63. .96 ISG 287
ATOM 287 CG PRO 39 159. .056 23. .886 4. .503 1. .00 63. .96 ISG 288
ATOM 288 C PRO 39 159. .404 27. .350 3. .592 1. .00 63. .96 ISG 289
ATOM 289 O PRO 39 159. .498 27, .936 2. .514 1. .00 63. .96 ISG 290
ATOM 290 N GLY 40 158. .783 27. .888 4. .656 1. .00 77. .07 ISG 291
ATOM 291 CA GLY 40 158. .279 29. .214 4. .473 1. .00 77. .07 ISG 292
ATOM 292 C GLY 40 157. .288 29. .519 5. .539 1. .00 77. .07 ISG 293
ATOM 293 O GLY 40 156. .352 30. ,298 5. .343 1. .00 77. .07 ISG 294
ATOM 294 N MET 41 157. .482 28. , 914 6. .717 1. .00 92. .14 ISG 295
ATOM 295 CA MET 41 156. .582 29. .198 7. .785 1. .00 92. .14 ISG 296
ATOM 296 CB MET 41 156. .047 27. ,899 8. ,412 1. .00 92. ,14 ISG 297
ATOM 297 CG MET 41 154. .617 27. ,981 8. ,942 1. .00 92. ,14 ISG 298
ATOM 298 SD MET 41 154. .325 29. ,179 10. ,269 1. .00 92. ,14 ISG 299
ATOM 299 CE MET 41 152. ,562 28. ,764 10. ,397 1. .00 92. 14 ISG 300
ATOM 300 C MET 41 157. 466 29. 871 8. .789 1. 00 92. 14 ISG 301
ATOM 301 O MET 41 158. 400 29. 250 9. ,280 1. 00 92. 14 ISG 302
ATOM 302 N LYS 42 157. 266 31. 163 9. 117 1. 00107. 17 ISG 303
ATOM 303 CA LYS 42 158. ,195 31. ,670 10. ,091 1. .00107. ,17 ISG 304 ATOM 304 CB LYS 42 159..179 32..740 9..583 1..00107..17 ISG 305
ATOM 305 CG LYS 42 160. .364 32. .216 8. .763 1. .00107. .17 ISG 306
ATOM 306 CD LYS 42 159. .999 31. .671 7. .381 1. .00107. .17 ISG 307
ATOM 307 CE LYS 42 161. .215 31. .267 6. .542 1. .00107. .17 ISG 308
ATOM 308 NZ LYS 42 161. .713 29, .940 6. .968 1. .00107. .17 ISG 309
ATOM 309 C LYS 42 157. .446 32, .292 11. .221 1. .00107. .17 ISG 310
ATOM 310 O LYS 42 156. .518 33, .094 11. .080 1. .00107, .17 ISG 311
ATOM 311 N PRO 43 157. .863 31, .747 12, .332 1. .00113. .63 ISG 312
ATOM 312 CA PRO 43 157, .399 32, .020 13. .662 1. .00113, .63 ISG 313
ATOM 313 CD PRO 43 159, .122 31, .028 12. .355 1. .00113, .63 ISG 314
ATOM 314 CB PRO 43 158, .103 31, .001 14. .545 1. .00113. .63 ISG 315
ATOM 315 CG PRO 43 159. .464 30, .861 13. .845 1. .00113, .63 ISG 316
ATOM 316 C PRO 43 157. .673 33, .351 14. .272 1. .00113, .63 ISG 317
ATOM 317 O PRO 43 156. .734 33, .935 14 , .805 1. .00113. .63 ISG 318
ATOM 318 N ILE 44 158. .957 33, .789 14 , .228 1. .00114. .90 ISG 319
ATOM 319 CA ILE 44 159, .485 34, .898 14. .982 1. .00114. .90 ISG 320
ATOM 320 CB ILE 44 160. .977 35, .004 14. .880 1. .00114, .90 ISG 321
ATOM 321 CG2 ILE 44 161, .409 36, .275 15. .631 1. .00114. .90 ISG 322
ATOM 322 CGI ILE 44 161, .638 33, .722 15, .414 1. .00114. .90 ISG 323
ATOM 323 CDl ILE 44 161, .310 33, .430 16, .878 1. .00114. .90 ISG 324
ATOM 324 C ILE 44 158, .923 36. .200 14, .545 1. .00114, .90 ISG 325
ATOM 325 O ILE 44 158, .413 36. .967 15, .359 1. .00114, .90 ISG 326
ATOM 326 N LYS 45 158, .978 36, .492 13, .239 1. .00112, .21 ISG 327
ATOM 327 CA LYS 45 158, .370 37, .714 12, .830 1. .00112, .21 ISG 328
ATOM 328 CB LYS 45 158, .569 38, .045 11, .340 1. .00112 .21 ISG 329
ATOM 329 CG LYS 45 160, .031 38, .298 10, .964 1. .00112 .21 ISG 330
ATOM 330 CD LYS 45 160, .667 39, .479 11, .702 1. .00112 .21 ISG 331
ATOM 331 CE LYS 45 162, .129 39, .720 11, .318 1. .00112 .21 ISG 332
ATOM 332 NZ LYS 45 162, .647 40, .919 12, .014 1, .00112 .21 ISG 333
ATOM 333 C LYS 45 156, .932 37, .454 13 .065 1. .00112 .21 ISG 334
ATOM 334 O LYS 45 156, .548 36, .295 13, .191 1. .00112 .21 ISG 335
ATOM 335 N GLY 46 156, .055 38, .460 13, .203 1. .00103 .26 ISG 336
ATOM 336 CA GLY 46 154, .803 37, .813 13, .418 1. .00103 .26 ISG 337
ATOM 337 C GLY 46 153, .654 38, .721 13, .548 1. .00103 .26 ISG 338
ATOM 338 O GLY 46 153, .774 39, .876 13, .950 1. .00103 .26 ISG 339
ATOM 339 N ILE 47 152, .483 38, .170 13. .173 1. .00 94 .27 ISG 340
ATOM 340 CA ILE 47 151, .287 38, .853 13. .505 1. .00 94, .27 ISG 341
ATOM 341 CB ILE 47 150, .306 39, .127 12, .415 1. .00 94. .27 ISG 342
ATOM 342 CG2 ILE 47 148. .985 39, .546 13, .082 1. .00 94, .27 ISG 343
ATOM 343 CGI ILE 47 150. .870 40, .227 11, .510 1. .00 94, .27 ISG 344
ATOM 344 CDl ILE 47 151, .135 41, .539 12, .247 1. .00 94, .27 ISG 345
ATOM 345 C ILE 47 150, .653 38, .026 14, .555 1. .00 94, .27 ISG 346
ATOM 346 O ILE 47 150, .369 36, .843 14, .361 1, .00 94, .27 ISG 347
ATOM 347 N THR 48 150. .483 38, .656 15, .729 1. .00 81, .86 ISG 348
ATOM 348 CA THR 48 149. .928 38, .016 16, .870 1. .00 81, .86 ISG 349
ATOM 349 CB THR 48 150. .934 37, .719 17, .942 1. .00 81, .86 ISG 350
ATOM 350 OGl THR 48 151. .491 38, .927 18, .440 1. .00 81, .86 ISG 351
ATOM 351 CG2 THR 48 152. .040 36, .831 17, .348 1. .00 81, .86 ISG 352
ATOM 352 C THR 48 148. .958 38, .988 17, .437 1. .00 81, .86 ISG 353
ATOM 353 O THR 48 148. .746 40, .061 16. .870 1. .00 81, .86 ISG 354
ATOM 354 N ASN 49 148. .347 38, .626 18, .582 1. .00 71, .07 ISG 355
ATOM 355 CA ASN 49 147. .358 39, .476 19, .164 1. .00 71. .07 ISG 356
ATOM 356 CB ASN 49 147. .893 40. .856 19, .585 1. .00 71. .07 ISG 357
ATOM 357 CG ASN 49 146. .813 41. .547 20. .406 1. .00 71. .07 ISG 358
ATOM 358 ODl ASN 49 145. .665 41, .105 20. .445 1. .00 71. .07 ISG 359
ATOM 359 ND2 ASN 49 147. .185 42. .669 21. .079 1. .00 71. .07 ISG 360
ATOM 360 C ASN 49 146. .334 39. .664 18. .105 1. .00 71. .07 ISG 361 ATOM 361 O ASN 49 145..776 40.747 17..932 1..00 71.07 ISG 362
ATOM 362 N LEU 50 146. .084 38 .574 17. .358 1. .00 65 .68 ISG 363
ATOM 363 CA LEU 50 145, .153 38 .579 16, .277 1. .00 65 .68 ISG 364
ATOM 364 CB LEU 50 145, .302 37 .322 15, .390 1. .00 65 .68 ISG 365
ATOM 365 CG LEU 50 144, .460 37 .247 14. .093 1. .00 65 .68 ISG 366
ATOM 366 CD2 LEU 50 142. .952 37, .457 14. .318 1. .00 65 .68 ISG 367
ATOM 367 CDl LEU 50 144. .740 35, .924 13. .362 1. .00 65 .68 ISG 368
ATOM 368 C LEU 50 143. .809 38 .541 16 .906 1, .00 65 .68 ISG 369
ATOM 369 O LEU 50 143, .541 37 .728 17 .791 1, .00 65 .68 ISG 370
ATOM 370 N LYS 51 142, .935 39 .458 16. .470 1, .00 61 .56 ISG 371
ATOM 371 CA LYS 51 141, .588 39 .428 16. .935 1, .00 61 .56 ISG 372
ATOM 372 CB LYS 51 141. .159 40 .639 17. .785 1, .00 61 .56 ISG 373
ATOM 373 CG LYS 51 141, .890 40, .781 19, .121 1, .00 61 .56 ISG 374
ATOM 374 CD LYS 51 143, .299 41, .362 19, .000 1. .00 61, .56 ISG 375
ATOM 375 CE LYS 51 143, .306 42, .889 18. .889 1. .00 61 .56 ISG 376
ATOM 376 NZ LYS 51 144 .694 43 .399 18. .938 1. .00 61 .56 ISG 377
ATOM 377 C LYS 51 140, .776 39 .489 15, .696 1. .00 61 .56 ISG 378
ATOM 378 O LYS 51 141, .186 40 .106 14, .714 1, .00 61 .56 ISG 379
ATOM 379 N VAL 52 139. .611 38 .827 15, .682 1, .00 62 .02 ISG 380
ATOM 380 CA VAL 52 138, .838 38 .976 14, .495 1. .00 62 .02 ISG 381
ATOM 381 CB VAL 52 137, .816 37 .896 14, .267 1. .00 62 .02 ISG 382
ATOM 382 CGI VAL 52 138, .562 36, .566 14. .070 1. .00 62 .02 ISG 383
ATOM 383 CG2 VAL 52 136, .817 37 .876 15, .432 1. .00 62 .02 ISG 384
ATOM 384 C VAL 52 138, .165 40 .294 14, .653 1. .00 62 .02 ISG 385
ATOM 385 O VAL 52 137, .434 40 .535 15, .614 1, .00 62 .02 ISG 386
ATOM 386 N LYS 53 138, .505 41 .229 13. .750 1. .00 62 .49 ISG 387
ATOM 387 CA LYS 53 137, .927 42 .532 13, .823 1. .00 62 .49 ISG 388
ATOM 388 CB LYS 53 138, .643 43, .547 12. .919 1. .00 62 .49 ISG 389
ATOM 389 CG LYS 53 140. .101 43, .768 13. .328 1. .00 62 .49 ISG 390
ATOM 390 CD LYS 53 140. .263 44, .257 14. .769 1. .00 62 .49 ISG 391
ATOM 391 CE LYS 53 141. .723 44 .417 15. .198 1, .00 62 .49 ISG 392
ATOM 392 NZ LYS 53 141. .793 44 .891 16. .598 1. .00 62 .49 ISG 393
ATOM 393 C LYS 53 136, .505 42 .462 13, .405 1. .00 62 .49 ISG 394
ATOM 394 O LYS 53 135. .625 43, .002 14 , .074 1. .00 62 .49 ISG 395
ATOM 395 N ASP 54 136. .237 41, .774 12. .279 1. .00 63 .19 ISG 396
ATOM 396 CA ASP 54 134. .880 41. .764 11. .832 1. .00 63, .19 ISG 397
ATOM 397 CB ASP 54 134. .569 42. .915 10. .856 1. .00 63, .19 ISG 398
ATOM 398 CG ASP 54 133. .062 43, .014 10. .662 1. ,00 63, .19 ISG 399
ATOM 399 ODl ASP 54 132. .325 42 .195 11. .271 1. .00 63 .19 ISG 400
ATOM 400 OD2 ASP 54 132, .628 43, .923 9. .905 1. .00 63 .19 ISG 401
ATOM 401 C ASP 54 134, .622 40, .487 11. .109 1. .00 63, .19 ISG 402
ATOM 402 O ASP 54 135. .448 40, .031 10. .320 1. .00 63 , .19 ISG 403
ATOM 403 N VAL 55 133. .478 39, .846 11. .419 1. ,00 63. .75 ISG 404
ATOM 404 CA VAL 55 133. .057 38. .700 10. ,678 1. ,00 63. .75 ISG 405
ATOM 405 CB VAL 55 133. .034 37. .423 11. ,479 1. ,00 63. .75 ISG 406
ATOM 406 CGI VAL 55 132. .153 37. .594 12. .728 1. .00 63. .75 ISG 407
ATOM 407 CG2 VAL 55 132. .582 36. .286 10. .548 1. .00 63. .75 ISG 408
ATOM 408 C VAL 55 131. .684 39. .027 10. .171 1. .00 63. .75 ISG 409
ATOM 409 O VAL 55 130. ,692 38. .985 10. ,896 1. .00 63. .75 ISG 410
ATOM 410 N GLN 56 131. ,579 39. .351 8. ,874 1. .00 61. .63 ISG 411
ATOM 411 CA GLN 56 130. ,298 39. .771 8. ,397 1. 00 61. .63 ISG 412
ATOM 412 CB GLN 56 130. .379 40. .986 7. ,455 1. 00 61. .63 ISG 413
ATOM 413 CG GLN 56 129. ,020 41. ,497 6. 971 1. 00 61. .63 ISG 414
ATOM 414 CD GLN 56 129. .277 42. .689 6. ,057 1. .00 61. .63 ISG 415
ATOM 415 OEl GLN 56 128. .308 42. .259 6. ,681 1. 00 61. .63 ISG 416
ATOM 416 NE2 GLN 56 130. .580 42. .355 5. ,860 1. 00 61. ,63 ISG 417
ATOM 417 C GLN 56 129. 685 38. .649 7. 628 1. 00 61. .63 ISG 418 > > > > > > > > > > > > > > > > > > > > > > > > > | > > > > > ' > > > | > > > > > H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H o p p o d d d d p p p d d p p d d p p p p d d p p p p p p p p p p p p p d p p p p p p p p p p p o p p d d d p p d
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P Ω Ω Ω Ω Ω Ω Ω Ω Ω 3 P Ω Ω Ω Ω Ω Ω 3 0 Ω Ω 3 0 Ω Ω Ω Ω Ω O Ω Ω Ω Ω n 3 Ω Ω Ω Ω Ω Ω 3 o Ω n Ω Ω Ω Ω Ω tsi Cd M d d Ω ω P d Ω Ω d > Ώ Ω ro H H to > a O n Ω
G- ω d to H > Ω 63 ω d C3 to H CO H t H > N M M d to H to H
Ω CH ffi13 «13 1ffi3 1«3 1κ3 1a3 a13 as. n3 '0 1a3 iHr H_H H-H HCH HH HH Hc HCH Ωc ΩcH Ω ΩH <ta < < ta< < to< < ΩcH Ω_H ΩCH Ω- w,ι3 w13 w13 lι3 13 13 13 < < < < < < < 13 '0 13 ,0 'ι3 13 'τ3 ' M M M M M M M M M M M M M M M M M M M ι-< ι<; ι<1 κ; EH H CH EH CH EH CH κ; κ; κ; P P P P P P P CH ^ CH EH tH EH EH M M M M M M M M
si -J si 1 si si si si si si si si s si si si si si si σi σi σi cn cn cn σi en en cn en cn cn cn cn cn cn cn cn en cn cn σi cn σi cn c σn oi σ o o oi σi o σi oi cTi H H H H O o o o o o o o vD vo vo vo oo oo oo oo oo oo ω si si si si cn cn cn on en cn σi ui ui ui ui ui Ul Ul ιt* 4* 4* 4* 4* 4* 4* 4*
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H tO H tO tO tO tO tO tO tO tO H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H
H vo o 4* uι ui H tθ H o iD θo oo oo uι σι en cn cn σ 4* uι uι 4* ui ui ui si en ui ui to H to H O O to H to ui UJ -j en cn 4* 4* Ul 4* H H H H tO tO
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CD l0 H sl 4* 00 tO sl UI O H 4* sl sl sl sl H σ3 O VD 00 Ul UI 00 0n VD Ui σ CD UJ H tO 00 0n 0n V0 O l0 H sl UJ H 00 00 O t0 O ιt* l0 O O Ul tO 4> H t0 H t» si ι_ u * oι iD θ W in αi Φ _ μ ιi) i oι ιn o u u iB si ιn u iJi ιo μ ιιι oι iJi oι ιo .ι iD (» u u μ o ι u * iD in * si si u ιn co o υ o) θ -j * tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO H H H H H H H H H H H H H H H H H H H H H H H H H H tO tO tO tO tO tO tO tO tO uι ui ι^ uJ 4* tθ ιt* to uJ UJ UJ Ui H to ui 4* uι UJ to o o o oo si σ cn uι uι uι uι uι 4* uι uι σι uι en ιθ si vo sl OO OO OO VO -J OO VO O t H s] Ul sl 4* Ul 4* to oo vo uι cn uj m to uι tθ 4* to en uj σ si o uι to vD 4* H si oo H -i o ιo vD on cn ω o o to σi 4* H oo uι co ui 4* oo CD on vo σι oo σ vo o oo o on oo on o o to uι 4* ιn uι _i 4* tθ si en oo oo ιo tθ H o σι ui si uι D θ to uι o ui s] Ui ι^ si H Ui ιθ si vo H H Ul tO tO CD U1 01 UJ UI 00 00 4* OO O H O tO H H si to o to ui si oo σι ui (n uι oo H cn tθ si 4* σι oo 4* CD on s H si oo o to vo o uJ to to en uι ui si to H tO 4* H 00 O O -J it* -1 4* 4* sl t0 H 4* 4* U1 00
U1 4* 4* H H t t tO tO UJ 4_ Ul OT Ul Ul -i eD si σ> σι 4* ln Cn Ui en Ul t0 4* UJ 4* UI U1 4* UJ UI H H O O O H O tO H H O H H tO O H 4* Ul UJ 4* t UJ en 4* vD vo oo Λ to eθ si H m o ιn ιo uι en ιn to to en oo ιj3 ui ιt* si m uJ H 4* 4* iD Ui uι ∞ H UJ VD -i o to to cD vo -J ι^ ω -i uJ H UJ uι uJ si 4* H en si uJ cn H UJ Ui 4* H -i ιn uι uι to o o 4* ιn uJ si cn o cn cD VD tθ si uJ w w tθ H uι oo oo iD CD en vo o 4* si en tθ H to iD θn si ui 4* H
o o o o o o o o o o σ oσ o o o o o o o o o oo o o o o o o o o o o o o o oo o o o oo o σ o oo oo ooo o o o o o o o o o o o o o o o o o o o o oo o o oo o oo o o o o o oo o oo oo o o o oo o oo o σ o o o oo o o o o ιn » ^ » ^ ^ ι ^ ^ » « ιl* ^ ^ ^ . » » ι^ ^ u J u ω L- U U U ω ι u u _ ι u ω iJ u ω iιi ι>ι iιi u iJ iιi u J U U u ω ι u u u ι ι>ι o en cn en cn cn cn cn cn σι cn cn to to co to to to to tθ si si si si 4* 4* 4* 4* 4* 4* 4* H H H H θ o o o o o o H H H H H H H to to to to to to to to cn vo vo vo vo vD VD vo vD vo vD Ui UJ UJ UJ UJ UJ UJ ω si si si si u -J UJ UJ UJ ω w 4* 4* 4* 4* ιn uι uι uι uι uι uι to to to to to to to oo cD θo ∞ oo vo vD VD VD VD vo vo vo vo vo vo cn cn cn m cn cn en cn vo vo vD vo to to to to to in ui ui ui 4* 4* 4* 4* 4* 4* 4* to to to to to to to o o o o o o o o
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H to to w to to to w to to to to to to to to to to to to to to to to to to to to to to to to to to to to m m to to m to w to w to to to to to to to to to to to to m
Ω Ω Ω Ω Ω Ώ Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ώ Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ώ Ω Ω Ω Ω Ω Ω in in Ul Ui -l Ul Ul Ul Ul Ul Ul Ul -l Ul ln Ul Ul -l Ul Ul Ul Ul Ul Ul Ul Ul Ul Ul Ul Ul Ul Ul 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* tO H O VO OO s! OT to 4* UJ tO H O VO OO si σi U1 4* UJ tO H O VD CD si m Ul 4* W tO H O VO OO sl Cn in ιt* Ul tO H O VD OO si αi Ul 4* Ul tO H O VD OO sl θn
ATOM 532 CA GLN 72 121,.501 26..576 5..980 1.,00 50..68 ISG 533
ATOM 533 CB GLN 72 121. .818 26. .840 7. .461 1. ,00 50. .68 ISG 534
ATOM 534 CG GLN 72 120. .670 26. .484 8. .400 1. .00 50. .68 ISG 535
ATOM 535 CD GLN 72 120. .595 24. .968 8. .430 1. .00 50, .68 ISG 536
ATOM 536 OEl GLN 72 121. .590 24. ,288 8. .674 1. ,00 50. .68 ISG 537
ATOM 537 NE2 GLN 72 119. .383 24. .420 8. .160 1. ,00 50. .68 ISG 538
ATOM 538 C GLN 72 122. .745 26. .917 5. .235 1. .00 50. .68 ISG 539
ATOM 539 O GLN 72 123. .712 26. .158 5, .262 1. .00 50. .68 ISG 540
ATOM 540 N CYS 73 122. .758 28. .072 4. .542 1. ,00 54. .11 ISG 541
ATOM 541 CA CYS 73 123, .944 28. .408 3. .815 1. ,00 54, .11 ISG 542
ATOM 542 CB CYS 73 123, .837 28. .145 2, .303 1. .00 54, .11 ISG 543
ATOM 543 SG CYS 73 122. .660 29. .253 1. .476 1. .00 54. .11 ISG 544
ATOM 544 C CYS 73 124. .223 29. .867 3. .965 1. ,00 54. .11 ISG 545
ATOM 545 O CYS 73 123. .312 30. .690 4. .043 1. .00 54. .11 ISG 546
ATOM 546 N VAL 74 125. .523 30. .211 4. .036 1. .00 56. .69 ISG 547
ATOM 547 CA VAL 74 125. .928 31. .583 4. .055 1. .00 56. .69 ISG 548
ATOM 548 CB VAL 74 126, .591 31. .986 5. .333 1. .00 56. .69 ISG 549
ATOM 549 CGI VAL 74 127, .831 31, .109 5, .561 1. .00 56 .69 ISG 550
ATOM 550 CG2 VAL 74 126 , .844 33. .500 5. .264 1. .00 56. .69 ISG 551
ATOM 551 C VAL 74 126, .883 31. .733 2. .908 1. .00 56. .69 ISG 552
ATOM 552 O VAL 74 127, .829 30, .956 2 .781 1, .00 56 .69 ISG 553
ATOM 553 N SER 75 126 .586 32, .693 2 .002 1. .00 56 .86 ISG 554
ATOM 554 CA SER 75 127, .320 32, .918 0. .782 1. .00 56. .86 ISG 555
ATOM 555 CB SER 75 126, .532 33. .774 -0. .222 1. .00 56 .86 ISG 556
ATOM 556 OG SER 75 125 .356 33, .088 -0, .625 1, .00 56 .86 ISG 557
ATOM 557 C SER 75 128, .658 33 , .569 0, .938 1. .00 56. .86 ISG 558
ATOM 558 O SER 75 129, .694 32, .925 0, .790 1. .00 56. .86 ISG 559
ATOM 559 N THR 76 128 .675 34, .887 1, .231 1. .00 54 .30 ISG 560
ATOM 560 CA THR 76 129 .949 35 .543 1 .223 1. .00 54 .30 ISG 561
ATOM 561 CB THR 76 130, .031 36, .658 0, .215 1. .00 54, .30 ISG 562
ATOM 562 OGl THR 76 131 .315 37, .263 0, .261 1. .00 54 .30 ISG 563
ATOM 563 CG2 THR 76 128 .910 37, .685 0, .457 1. .00 54 .30 ISG 564
ATOM 564 C THR 76 130, .293 36. .071 2. .573 1. .00 54, .30 ISG 565
ATOM 565 O THR 76 130, .107 37, .248 2, .876 1. .00 54, .30 ISG 566
ATOM 566 N GLY 77 130, .854 35, .198 3, .422 1. .00 50, .92 ISG 567
ATOM 567 CA GLY 77 131 .258 35 .661 4, .707 1. .00 50 .92 ISG 568
ATOM 568 C GLY 77 132, .541 36, .393 4, .519 1. .00 50, .92 ISG 569
ATOM 569 O GLY 77 133, .368 36, .016 3, .689 1. .00 50, .92 ISG 570
ATOM 570 N MET 78 132 .737 37, .470 5, .299 1. .00 51, .44 ISG 571
ATOM 571 CA MET 78 133, .968 38. .192 5. .214 1. .00 51. .44 ISG 572
ATOM 572 CB MET 78 133, .796 39. .662 4, .798 1. ,00 51, .44 ISG 573
ATOM 573 CG MET 78 133, .305 39. .837 3, .361 1. .00 51, .44 ISG 574
ATOM 574 SD MET 78 134 .458 39 .210 2. .104 1. .00 51. .44 ISG 575
ATOM 575 CE MET 78 135, .788 40. .373 2. .523 1. .00 51. .44 ISG 576
ATOM 576 C MET 78 134, .541 38, .192 6, .590 1. .00 51, .44 ISG 577
ATOM 577 O MET 78 133, .880 38, .600 7, .543 1. .00 51, .44 ISG 578
ATOM 578 N THR 79 135. .790 37. .715 6. .738 1. .00 58. .85 ISG 579
ATOM 579 CA THR 79 136, .365 37, .717 8. .050 1. .00 58. .85 ISG 580
ATOM 580 CB THR 79 136. .580 36, .346 8. .620 1. .00 58. .85 ISG 581
ATOM 581 OGl THR 79 135. .346 35, .646 8, .690 1. .00 58, .85 ISG 582
ATOM 582 CG2 THR 79 137, .187 36, .487 10, .026 1. ,00 58. .85 ISG 583
ATOM 583 C THR 79 137, .698 38. .386 7, .981 1. ,00 58. .85 ISG 584
ATOM 584 O THR 79 138, .453 38, .199 7, .029 1. .00 58. .85 ISG 585
ATOM 585 N VAL 80 138. .026 39, .206 8. .998 1. .00 70. .78 ISG 586
ATOM 586 CA VAL 80 139. .306 39. .856 8. .974 1. .00 70. .78 ISG 587
ATOM 587 CB VAL 80 139. .221 41. .355 9. .044 1. .00 70. .78 ISG 588
ATOM 588 CGI VAL 80 138. .560 41. .757 10. .373 1. 00 70. ,78 ISG 589 ATOM 589 CG2 VAL 80 140..636 41..931 8..860 1..00 70..78 ISG 590
ATOM 590 C VAL 80 140, .112 39. .394 10. .162 1. .00 70. .78 ISG 591
ATOM 591 O VAL 80 139. .599 39. .385 11. .280 1. .00 70. .78 ISG 592
ATOM 592 N THR 81 141 .383 38, .972 9. .912 1, .00 83. .73 ISG 593
ATOM 593 CA THR 81 142, .396 38, .517 10. .860 1, .00 83, .73 ISG 594
ATOM 594 CB THR 81 142, .174 37. .112 11. .339 1, .00 83, .73 ISG 595
ATOM 595 OGl THR 81 142, .264 36. .207 10. .248 1. .00 83. .73 ISG 596
ATOM 596 CG2 THR 81 140, .785 37. .016 11. .992 1. .00 83. .73 ISG 597
ATOM 597 C THR 81 143 .734 38, .479 10, .074 1 .00 83. .73 ISG 598
ATOM 598 O THR 81 143 .765 39. .149 9, .048 1. .00 83. .73 ISG 599
ATOM 599 N GLY 82 144 .873 37. .789 10, .504 1. .00 91. .89 ISG 600
ATOM 600 CA GLY 82 146 .021 37. .628 9. .603 1, .00 91, .89 ISG 601
ATOM 601 C GLY 82 147 .383 37. .857 10. .205 1, .00 91, .89 ISG 602
ATOM 602 O GLY 82 147, .577 37. .886 11. .419 1. .00 91, .89 ISG 603
ATOM 603 N LYS 83 148 .391 37. .966 9, .302 1 .00 93, .30 ISG 604
ATOM 604 CA LYS 83 149 .760 38. .222 9, .649 1. .00 93, .30 ISG 605
ATOM 605 CB LYS 83 150 .583 36, .948 9. .889 1, .00 93, .30 ISG 606
ATOM 606 CG LYS 83 151, .995 37, .209 10. .417 1, .00 93, .30 ISG 607
ATOM 607 CD LYS 83 152, .623 35, .949 11. .010 1, .00 93, .30 ISG 608
ATOM 608 CE LYS 83 151, .910 35, .489 12. .283 1, .00 93, .30 ISG 609
ATOM 609 NZ LYS 83 151 .993 34, .017 12, .407 1 .00 93 .30 « ISG 610
ATOM 610 C LYS 83 150 .406 38, .973 8, .515 1 .00 93, .30 ISG 611
ATOM 611 O LYS 83 149 .945 38. .932 7, .376 1, .00 93, .30 ISG 612
ATOM 612 N SER 84 151. .499 39, .698 8. .827 1, .00 89, .86 ISG 613
ATOM 613 CA SER 84 152. .240 40. .521 7. .913 1, .00 89, .86 ISG 614
ATOM 614 CB SER 84 151 .365 41. .636 7 .334 1 .00 89 .86 ISG 615
ATOM 615 OG SER 84 150 .933 42. .477 8, .392 1 .00 89, .86 ISG 616
ATOM 616 C SER 84 153 .274 41. .169 8, .786 1 .00 89, .86 ISG 617
ATOM 617 0 SER 84 153 .134 41. .107 10, .005 1, .00 89, .86 ISG 618
ATOM 618 N PHE 85 154. .344 41. .806 8. .255 1, .00 82, .53 ISG 619
ATOM 619 CA PHE 85 155. .213 42. .297 9. .288 1, .00 82 , .53 ISG 620
ATOM 620 CB PHE 85 155 .992 41. .141 9 .951 1 .00 82 .53 ISG 621
ATOM 621 CG PHE 85 156 .754 41, .619 11, .139 1, .00 82 .53 ISG 622
ATOM 622 CDl PHE 85 156 .162 41. .611 12, .381 1, .00 82, .53 ISG 623
ATOM 623 CD2 PHE 85 158. .051 42. .063 11, .022 1, .00 82, .53 ISG 624
ATOM 624 CE1 PHE 85 156, .849 42. .041 13 , .490 1. .00 82 , .53 ISG 625
ATOM 625 CE2 PHE 85 158, .744 42. .494 12. .128 1. .00 82. .53 ISG 626
ATOM 626 CZ PHE 85 158, .143 42. .485 13. .365 1, .00 82. .53 ISG 627
ATOM 627 C PHE 85 156, .161 43, .367 8, .838 1, .00 82, .53 ISG 628
ATOM 628 0 PHE 85 156, .488 43, .488 7. .660 1, .00 82, .53 ISG 629
ATOM 629 N MET 86 156, .584 44. .171 9. .844 1. .00 74 , .26 ISG 630
ATOM 630 CA MET 86 157, .495 45. .286 9. .901 1. .00 74. .26 ISG 631
ATOM 631 CB MET 86 157, .117 46. .478 9, .004 1. .00 74, .26 ISG 632
ATOM 632 CG MET 86 157, .142 46. .135 7. .516 1. .00 74. .26 ISG 633
ATOM 633 SD MET 86 158, .696 45. .370 6. .967 1. .00 74. .26 ISG 634
ATOM 634 CE MET 86 159. .564 46. .949 6. .807 1. .00 74. .26 ISG 635
ATOM 635 C MET 86 157. .315 45. .726 11. .319 1. .00 74. .26 ISG 636
ATOM 636 O MET 86 157. .725 45. .039 12. ,253 1. .00 74. ,26 ISG 637
ATOM 637 N GLY 87 156. .710 46. .913 11. .507 1. .00 65. .68 ISG 638
ATOM 638 CA GLY 87 156. .335 47. .347 12. .820 1. .00 65. .68 ISG 639
ATOM 639 C GLY 87 155. .047 48. ,088 12. .633 1. .00 65. .68 ISG 640
ATOM 640 O GLY 87 155. .025 49. ,147 12. .009 1. .00 65. .68 ISG 641
ATOM 641 N GLY 88 153. .932 47. ,558 13. ,179 1. ,00 60. .37 ISG 642
ATOM 642 CA GLY 88 152. .682 48. .240 12. .995 1. .00 60. .37 ISG 643
ATOM 643 C GLY 88 151. .574 47. .237 13. .054 1. .00 60. .37 ISG 644
ATOM 644 0 GLY 88 151. .748 46. ,111 13. .516 1. .00 60. ,37 ISG 645
ATOM 645 N ASN 89 150. .381 47. 642 12. .583 1. ,00 58. .47 ISG 646 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H o p p p o d d p p d d d d d p p p p p p p d d o d d d p p p p p o p p p p p p p p p p p p p d d p p d d p p d d d
3 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 33 23
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01 1n Ul Ul Ul Ul Ul Ul Ul Ul U1 4* 4* 4* 4* 4* i^ 4* 4* 4* 4* UJ UI UI UJ UJ UI UJ UJ UI UJ tO tO tO tO tO tO tO t tO tO H H H H H H H H H O O O O O O o vo oo si en ιn 4* uJ tθ H o vD θθ si cn ui 4* uι t H θ VD θθ si σι ui 4* u tθ H θ vD θo -j σι uι 4* uJ tθ H o vD θθ si σι ui 4* UJ to O VD 00 si 01 Ul 4*
ATOM 760 N LEU 104 115..056 17..877 11.,740 1..00 38..16 ISG 761
ATOM 761 CA LEU 104 114. .000 18. .145 12. .675 1. ,00 38. .16 ISG 762
ATOM 762 CB LEU 104 112. .836 18, .929 12. .045 1. .00 38. .16 ISG 763
ATOM 763 CG LEU 104 113. .227 20, .322 11. .519 1. .00 38. .16 ISG 764
ATOM 764 CD2 LEU 104 113. .906 21, .156 12. .612 1. .00 38. .16 ISG 765
ATOM 765 CDl LEU 104 112. .020 21, .045 10. .905 1. .00 38. .16 ISG 766
ATOM 766 C LEU 104 113, .418 16 .837 13. .116 1. .00 38, .16 ISG 767
ATOM 767 O LEU 104 113. .167 15, .953 12. .299 1. .00 38. .16 ISG 768
ATOM 768 N LEU 105 113. .193 16 .676 14, .436 1. .00 39. .31 ISG 769
ATOM 769 CA LEU 105 112. .604 15, .458 14. .913 1. .00 39. .31 ISG 770
ATOM 770 CB LEU 105 113. .639 14 .424 15, .397 1. .00 39. .31 ISG 771
ATOM 771 CG LEU 105 113. .038 13, .059 15. .779 1. .00 39. .31 ISG 772
ATOM 772 CD2 LEU 105 114, .036 12 .206 16. .577 1. .00 39, .31 ISG 773
ATOM 773 CDl LEU . 105 112. .479 12, .339 14 , .542 1. .00 39. .31 ISG 774
ATOM 774 C LEU 105 111. .696 15, .822 16. .049 1. .00 39. .31 ISG 775
ATOM 775 O LEU 105 111. .559 16, .994 16. .393 1. .00 39, .31 ISG 776
ATOM 776 N ARG 106 111. .010 14. .823 16. .641 1. .00 39. .38 ISG 777
ATOM 777 CA ARG 106 110. .122 15, .095 17. .735 1. .00 39, .38 ISG 778
ATOM 778 CB ARG 106 108. .633 14, .972 17. .359 1. .00 39. .38 ISG 779
ATOM 779 CG ARG 106 108, .244 13 .643 16. .703 1. .00 39. .38 ISG 780
ATOM 780 CD ARG 106 108, .426 12, .401 17. .575 1. .00 39. .38 ISG 781
ATOM 781 NE ARG 106 107. .995 11 .233 16. .757 1. .00 39. .38 ISG 782
ATOM 782 CZ ARG 106 108. .854 10, .679 15. .850 1. .00 39. .38 ISG 783
ATOM 783 NHl ARG 106 110, .101 11 .204 15 .683 1, .00 39. .38 ISG 784
ATOM 784 NH2 ARG 106 108. .459 9, .607 15. .104 1. .00 39. .38 ISG 785
ATOM 785 C ARG 106 110. .417 14 .155 18 .858 1. .00 39 .38 ISG 786
ATOM 786 O ARG 106 110, .900 13 .043 18. .649 1. .00 39, .38 ISG 787
ATOM 787 N ASP 107 110, .149 14 .613 20 .098 1. .00 37 .66 ISG 788
ATOM 788 CA ASP 107 110, .346 13 .803 21 .264 1. .00 37, .66 ISG 789
ATOM 789 CB ASP 107 111, .016 14 .578 22 .414 1. .00 37 .66 ISG 790
ATOM 790 CG ASP 107 111, .392 13 .602 23. .518 1. .00 37, .66 ISG 791
ATOM 791 ODl ASP 107 110, .967 12 .419 23 .439 1. .00 37 .66 ISG 792
ATOM 792 OD2 ASP 107 112, .110 14 .031 24. .461 1, .00 37, .66 ISG 793
ATOM 793 C ASP 107 108, .976 13 .400 21 .707 1, .00 37 .66 ISG 794
ATOM 794 O ASP 107 108, .180 14, .236 22, .124 1, .00 37, .66 ISG 795
ATOM 795 N GLU 108 108, .651 12 .101 21 .594 1 .00 36 .18 ISG 796
ATOM 796 CA GLU 108 107. .336 11 .627 21 .915 1, .00 36, .18 ISG 797
ATOM 797 CB GLU 108 107. .145 10 .156 21 .513 1, .00 36 .18 ISG 798
ATOM 798 CG GLU 108 107, .180 9 .963 19, .995 1, .00 36, .18 ISG 799
ATOM 799 CD GLU 108 107, .189 8 .472 19 .698 1 .00 36 .18 ISG 800
ATOM 800 OEl GLU 108 107, .204 7 .675 20, .673 1, .00 36, .18 ISG 801
ATOM 801 OE2 GLU 108 107, .185 8 .112 18 .491 1, .00 36. .18 ISG 802
ATOM 802 C GLU 108 107, .048 11 .764 23 .379 1, .00 36. .18 ISG 803
ATOM 803 O GLU 108 105, .953 12 .172 23 .763 1, .00 36, .18 ISG 804
ATOM 804 N GLU 109 108, .019 11 .427 24, .248 1, .00 37. .25 ISG 805
ATOM 805 CA GLU 109 107, .743 11 .459 25 .654 1, .00 37. .25 ISG 806
ATOM 806 CB GLU 109 108, .938 10 .966 26 .487 1, .00 37, .25 ISG 807
ATOM 807 CG GLU 109 108, .701 10 .974 27 .997 1, .00 37, .25 ISG 808
ATOM 808 CD GLU 109 109, .967 10 .445 28, .656 1, .00 37, .25 ISG 809
ATOM 809 OEl GLU 109 110, .835 9 .909 27 .916 1. .00 37, .25 ISG 810
ATOM 810 OE2 GLU 109 110, .085 10 .567 29, .904 1. .00 37, .25 ISG 811
ATOM 811 C GLU 109 107. .422 12 .859 26, .091 1, .00 37. .25 ISG 812
ATOM 812 O GLU 109 106. .420 13, .077 26, .770 1, .00 37. .25 ISG 813
ATOM 813 N THR 110 108. .285 13, .836 25. .738 1. .00 39. .41 ISG 814
ATOM 814 CA THR 110 108. .102 15 .208 26 .129 1. .00 39. .41 ISG 815
ATOM 815 CB THR 110 109. .367 16, .014 26, .042 1. .00 39. .41 ISG 816
ATOM 816 OGl THR 110 109. .178 17, .284 26, .650 1, .00 39. .41 ISG 817 ATOM 817 CG2 THR 110 109.765 16.180 24.567 1.00 39.41 ISG 818
ATOM 818 C THR 110 107. 048 15. 896 25. 312 1. 00 39. 41 ISG 819
ATOM 819 O THR 110 106. ,246 16. 668 25. 835 1. 00 39. ,41 ISG 820
ATOM 820 N GLY 111 107. ,021 15. 633 23. 993 1. 00 41. ,39 ISG 821
ATOM 821 CA GLY 111 106. ,090 16. 281 23. 118 1. 00 41. ,39 ISG 822
ATOM 822 C GLY 111 106. .747 17. 508 22. 553 1. 00 41. ,39 ISG 823
ATOM 823 O GLY 111 106. .086 18. 313 21. 900 1. 00 41. ,39 ISG 824
ATOM 824 N LEU 112 108. .066 17. 693 22. ,790 1. 00 44. .91 ISG 825
ATOM 825 CA LEU 112 108. .729 18. 849 22. ,249 1. 00 44. .91 ISG 826
ATOM 826 CB LEU 112 109. ,616 19. 621 23. ,240 1. ,00 44. .91 ISG 827
ATOM 827 CG LEU 112 108. .805 20. ,451 24. ,252 1. 00 44. .91 ISG 828
ATOM 828 CD2 LEU 112 107. .925 19. 560 25. .142 1. ,00 44. .91 ISG 829
ATOM 829 CDl LEU 112 108. .011 21. ,562 23. .542 1. 00 44. .91 ISG 830
ATOM 830 C LEU 112 109. .554 18. ,468 21. ,060 1. ,00 44. .91 ISG 831
ATOM 831 O LEU 112 109. .932 17. ,315 20. ,856 1. ,00 44. ,91 ISG 832
ATOM 832 N PRO 113 109. .793 19. ,460 20. .244 1, ,00 45. .36 ISG 833
ATOM 833 CA PRO 113 110. ,527 19. ,300 19. .016 1. ,00 45. .36 ISG 834
ATOM 834 CD PRO 113 109. .026 20. ,693 20. ,278 1, .00 45. .36 ISG 835
ATOM 835 CB PRO 113 110. .178 20. .519 18. .160 1. .00 45. .36 ISG 836
ATOM 836 CG PRO 113 109, .644 21. ,555 19. .166 1. .00 45. .36 ISG 837
ATOM 837 C PRO 113 112. .000 19. .170 19, .255 1. .00 45. .36 ISG 838
ATOM 838 O PRO 113 112. .480 19. .640 20. .284 1. .00 45, .36 ISG 839
ATOM 839 N VAL 114 112, .739 18, .534 18, .319 1, .00 44, .68 ISG 840
ATOM 840 CA VAL 114 114, .164 18. .445 18, .478 1. .00 44, .68 ISG 841
ATOM 841 CB VAL 114 114, .680 17. .079 18, .823 1. .00 44, .68 ISG 842
ATOM 842 CGI VAL 114 114, .460 16, .152 17, .626 1. .00 44 .68 ISG 843
ATOM 843 CG2 VAL 114 116, .153 17, .207 19, .245 1. .00 44, .68 ISG 844
ATOM 844 C VAL 114 114 .800 18, .893 17, .197 1. .00 44 .68 ISG 845
ATOM 845 O VAL 114 114, .191 18. .832 16 .130 1, .00 44, .68 ISG 846
ATOM 846 N PHE 115 116 .050 19, .391 17, .291 1. .00 43 .22 ISG 847
ATOM 847 CA PHE 115 116, .723 19. .975 16 .165 1. .00 43 .22 ISG 848
ATOM 848 CB PHE 115 116 .560 21. .501 16, .267 1, .00 43 .22 ISG 849
ATOM 849 CG PHE 115 116, .932 22, .227 15 .029 1, .00 43 .22 ISG 850
ATOM 850 CDl PHE 115 118 .239 22, .546 14, .750 1. .00 43, .22 ISG 851
ATOM 851 CD2 PHE 115 115, .939 22, .618 14 .164 1, .00 43 .22 ISG 852
ATOM 852 CE1 PHE 115 118 .545 23, .235 13 .601 1, .00 43, .22 ISG 853
ATOM 853 CE2 PHE 115 116 .236 23, .306 13 .016 1, .00 43 .22 ISG 854
ATOM 854 CZ PHE 115 117 .543 23 .613 12 .738 1, .00 43, .22 ISG 855
ATOM 855 C PHE 115 118 .186 19, .665 16 .331 1, .00 43 .22 ISG 856
ATOM 856 0 PHE 115 118 .739 19 .833 17 .418 1, .00 43, .22 ISG 857
ATOM 857 N LYS 116 118 .863 19, .213 15, .254 1 .00 38 .14 ISG 858
ATOM 858 CA LYS 116 120, .265 18 .911 15 .385 1, .00 38 .14 ISG 859
ATOM 859 CB LYS 116 120 .546 17, .422 15 .646 1 .00 38 .14 ISG 860
ATOM 860 CG LYS 116 122 .029 17 .105 15 .849 1, .00 38 .14 ISG 861
ATOM 861 CD LYS 116 122 .282 15 .693 16 .381 1, .00 38 .14 ISG 862
ATOM 862 CE LYS 116 123 .763 15 .371 16 .585 1 .00 38 .14 ISG 863
ATOM 863 NZ LYS 116 123 .916 13 .986 17 .086 1, .00 38 .14 ISG 864
ATOM 864 C LYS 116 120 .947 19, .268 14 .099 1 .00 38 .14 ISG 865
ATOM 865 O LYS 116 120 .294 19 .432 13 .070 1, .00 38 .14 ISG 866
ATOM 866 N SER 117 122 .292 19 .408 14 .130 1 .00 36 .50 ISG 867
ATOM 867 CA SER 117 123 .012 19 .732 12 .929 1, .00 36 .50 ISG. 868
ATOM 868 CB SER 117 124 .066 20 .836 13 .122 1 .00 36 .50 ISG 869
ATOM 869 OG SER 117 125 .068 20 .404 14 .031 1, .00 36 .50 ISG 870
ATOM 870 C SER 117 123 .720 18 .493 12 .480 1 .00 36 .50 ISG 871
ATOM 871 O SER 117 124 .633 18 .005 13 .144 1, .00 36 .50 ISG 872
ATOM 872 N GLU 118 123 .275 17 .942 11 .333 1 .00 36 .05 ISG 873
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Figure imgf000682_0001
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ATOM 1159 CD2 LEU 155 135,.840 28..564 16.046 1..00 49,.81 1SG1160
ATOM 1160 CDl LEU 155 138, .316 29. .147 16 .278 1. .00 49, .81 1SG1161
ATOM 1161 C LEU 155 135. .304 26, .667 13 .858 1. .00 49, .81 1SG1162
ATOM 1162 O LEU 155 134, .467 26, .559 14, .753 1. .00 49, .81 1SG1163
ATOM 1163 N MET 156 134, .981 27. .132 12 .637 1. .00 48. .61 1SG1164
ATOM 1164 CA MET 156 133, .655 27. .590 12 .324 1, .00 48 .61 1SG1165
ATOM 1165 CB MET 156 133 .541 28. .120 10 .883 1. .00 48 .61 1SG1166
ATOM 1166 CG MET 156 134. .367 29. .386 10 .642 1, .00 48 .61 1SG1167
ATOM 1167 SD MET 156 134. .267 30. .052 8 .953 1, .00 48 .61 1SG1168
ATOM 1168 CE MET 156 135, .381 31. .452 9 .268 1, .00 48 .61 1SG1169
ATOM 1169 C MET 156 132, .673 26, .466 12 .477 1. .00 48. .61 1SG1170
ATOM 1170 O MET 156 131, .591 26, .666 13 .026 1. .00 48. .61 1SG1171
ATOM 1171 N CYS 157 133, .018 25, .251 12 .007 1. .00 51. .40 1SG1172
ATOM 1172 CA CYS 157 132, .089 24. .156 12 .077 1. .00 51. .40 1SG1173
ATOM 1173 CB CYS 157 132, .628 22. .872 11 .425 1. .00 51, .40 1SG1174
ATOM 1174 SG CYS 157 132. .069 22, .592 9 .728 1. .00 51, .40 1SG1175
ATOM 1175 C CYS 157 131. .697 23, .856 13, .499 1. .00 51, .40 1SG1176
ATOM 1176 O CYS 157 130 .498 23, .777 13 .764 1, .00 51 .40 1SG1177
ATOM 1177 N PRO 158 132 .590 23, .679 14 .444 1. .00 55 .66 1SG1178
ATOM 1178 CA PRO 158 132 .099 23, .489 15 .776 1. .00 55 .66 1SG1179
ATOM 1179 CD PRO 158 133. .706 22, .776 14 .228 1. .00 55 .66 1SG1180
ATOM 1180 CB PRO 158 133. .270 22, .976 16 .601 1. .00 55 .66 1SG1181
ATOM 1181 CG PRO 158 134. .035 22, .125 15 .581 1. .00 55 .66 1SG1182
ATOM 1182 C PRO 158 131. .430 24, .700 16 .307 1. .00 55, .66 1SG1183
ATOM 1183 O PRO 158 130, .696 24, .589 17 .288 1. .00 55 .66 1SG1184
ATOM 1184 N ALA 159 131, .663 25, .861 15 .682 1. .00 56 .12 1SG1185
ATOM 1185 CA ALA 159 131, .032 27, .051 16 .147 1. .00 56, .12 1SG1186
ATOM 1186 CB ALA 159 131, .391 28, .287 15 .303 1. .00 56, .12 1SG1187
ATOM 1187 C ALA 159 129 .563 26, .837 16 .032 1. .00 56 .12 1SG1188
ATOM 1188 O ALA 159 128, .796 27, .248 16 .901 1, .00 56 .12 1SG1189
ATOM 1189 N ILE 160 129 .104 26. .149 14 .972 1. .00 56 .60 1SG1190
ATOM 1190 CA ILE 160 127, .680 26. .039 14 .875 1. .00 56 .60 1SG1191
ATOM 1191 CB ILE 160 127, .243 25. .753 13 .460 1. .00 56 .60 1SG1192
ATOM 1192 CG2 ILE 160 125, .705 25. .812 13 .383 1. .00 56 .60 1SG1193
ATOM 1193 CGI ILE 160 127, .876 26. .791 12 .518 1. .00 56 .60 1SG1194
ATOM 1194 CDl ILE 160 127, .467 28. .229 12 .836 1. .00 56, .60 1SG1195
ATOM 1195 C ILE 160 127, .229 24. .918 15, .791 1. .00 56, .60 1SG1196
ATOM 1196 O ILE 160 126. .282 24. .193 15, .500 1. .00 56, .60 1SG1197
ATOM 1197 N ASP 161 127. .875 24. .797 16, .972 1. ,00 54. .30 1SG1198
ATOM 1198 CA ASP 161 127. .540 23, .895 18, .039 1. .00 54, .30 1SG1199
ATOM 1199 CB ASP 161 128, .628 23, .766 19 .124 1. .00 54 .30 1SG1200
ATOM 1200 CG ASP 161 128, .808 25, .095 19 .844 1. .00 54, .30 1SG1201
ATOM 1201 ODl ASP 161 129, .052 26. .120 19, .156 1. .00 54, .30 1SG1202
ATOM 1202 OD2 ASP 161 128, .721 25. .098 21, .101 1. .00 54. .30 1SG1203
ATOM 1203 C ASP 161 126, .321 24. .484 18, .655 1. ,00 54, .30 1SG1204
ATOM 1204 O ASP 161 125. .593 23. .847 19, .415 1. ,00 54. .30 1SG1205
ATOM 1205 N ALA 162 126. .096 25. .760 18, .309 1. ,00 49. .03 1SG1206
ATOM 1206 CA ALA 162 125. .042 26. .570 18. .'826 1. .00 49. .03 1SG1207
ATOM 1207 CB ALA 162 124. .967 27. ,949 18 , .150 1. .00 49. .03 1SG1208
ATOM 1208 C ALA 162 123. .745 25. ,876 18. .582 1. .00 49. .03 1SG1209
ATOM 1209 O ALA 162 122. ,815 26. .033 19. .367 1. .00 49. .03 1SG1210
ATOM 1210 N VAL 163 123. .605 25. .118 17, .481 1. .00 47. .27 1SG1211
ATOM 1211 CA VAL 163 122. .334 24. .480 17, .292 1. .00 47. .27 1SG1212
ATOM 1212 CB VAL 163 122. .254 23. .674 16, .024 1. .00 47. .27 1SG1213
ATOM 1213 CGI VAL 163 122. .336 24. .640 14. .832 1. .00 47. .27 1SG1214
ATOM 1214 CG2 VAL 163 123. .366 22. .612 16. .024 1. .00 47. .27 1SG1215
ATOM 1215 C VAL 163 122. ,044 23. ,571 18. .454 1. 00 47. ,27 1SG1216 ATOM 1216 O VAL 163 120.992 23.,668 19.083 1.00 47..27 1SG1217
ATOM 1217 N LEU 164 122. 981 22. ,682 18. 817 1. 00 45. ,67 1SG1218
ATOM 1218 CA LEU 164 122. 660 21. .758 19. 863 1. 00 45. ,67 1SG1219
ATOM 1219 CB LEU 164 123. 812 20. .762 20. 119 1. ,00 45. ,67 1SG1220
ATOM 1220 CG LEU 164 123. ,506 19. .614 21. ,107 1. ,00 45. ,67 1SG1221
ATOM 1221 CD2 LEU 164 122. ,340 18. .751 20. .601 1. ,00 45. .67 1SG1222
ATOM 1222 CDl LEU 164 123. ,310 20. .104 22. .551 1. ,00 45. .67 1SG1223
ATOM 1223 C LEU 164 122. ,403 22. .512 21. .129 1. ,00 45. .67 1SG1224
ATOM 1224 O LEU 164 121. .375 22. .316 21. .776 1. .00 45. .67 1SG1225
ATOM 1225 N VAL 165 123. .334 23. .396 21. .530 1. .00 43. .90 1SG1226
ATOM 1226 CA VAL 165 123. .129 24. .068 22. .778 1. .00 43. .90 1SG1227
ATOM 1227 CB VAL 165 124. .322 24. .879 23. ,194 1. .00 43. .90 1SG1228
ATOM 1228 CGI VAL 165 123. .964 25. .655 24. ,474 1. .00 43. .90 1SG1229
ATOM 1229 CG2 VAL 165 125. .530 23. .940 23. .347 1. .00 43. .90 1SG1230
ATOM 1230 C VAL 165 121. .973 25. .017 22. .720 1. .00 43, .90 1SG1231
ATOM 1231 O VAL 165 120. .994 24, .859 23. .446 1. .00 43, .90 1SG1232
ATOM 1232 N TYR 166 122. .100 26, .054 21. .867 1, .00 45, .20 1SG1233
ATOM 1233 CA TYR 166 121. .176 27, .150 21. .739 1, .00 45 .20 1SG1234
ATOM 1234 CB TYR 166 121. .822 28 .361 21. .047 1. .00 45 .20 1SG1235
ATOM 1235 CG TYR 166 122. .982 28 .779 21. .881 1. .00 45 .20 1SG1236
ATOM 1236 CDl TYR 166 124. .195 28 .145 21. .737 1 .00 45 .20 1SG1237
ATOM 1237 CD2 TYR 166 122. .864 29 .796 22, .800 1 .00 45 .20 1SG1238
ATOM 1238 CE1 TYR 166 125. .276 28, .518 22. .499 1. .00 45, .20 1SG1239
ATOM 1239 CE2 TYR 166 123. .943 30, .173 23. .565 1, .00 45, .20 1SG1240
ATOM 1240 CZ TYR 166 125. .150 29, .534 23. .415 1. .00 45 .20 1SG1241
ATOM 1241 OH TYR 166 126. .258 29, .920 24. .198 1. .00 45 .20 1SG1242
ATOM 1242 C TYR 166 119. .900 26, .887 20. .990 1, .00 45 .20 1SG1243
ATOM 1243 O TYR 166 118. .822 27, .195 21. .496 1, .00 45 .20 1SG1244
ATOM 1244 N VAL 167 119. .972 26, .343 19. .753 1, .00 45 .40 1SG1245
ATOM 1245 CA VAL 167 118. .759 26 .307 18. .974 1. .00 45 .40 1SG1246
ATOM 1246 CB VAL 167 118. .923 25 .999 17, .503 1. .00 45 .40 1SG1247
ATOM 1247 CGI VAL 167 119. .981 26 .950 16, .920 1 .00 45 .40 1SG1248
ATOM 1248 CG2 VAL 167 119. .143 24 .500 17, .265 1 .00 45 .40 1SG1249
ATOM 1249 C VAL 167 117. .766 25 .341 19, .535 1 .00 45 .40 1SG1250
ATOM 1250 0 VAL 167 116, .581 25 .655 19, .632 1 .00 45 .40 1SG1251
ATOM 1251 N ASN 168 118, .224 24 .140 19, .931 1 .00 45 .97 1SG1252
ATOM 1252 CA ASN 168 117, .311 23 .137 20, .402 1 .00 45 .97 1SG1253
ATOM 1253 CB ASN 168 118, .026 21 .836 20, .815 1 .00 45 .97 1SG1254
ATOM 1254 CG ASN 168 116, .975 20 .772 21, .104 1 .00 45 .97 1SG1255
ATOM 1255 ODl ASN 168 115, .784 21 .058 21 .204 1 .00 45 .97 1SG1256
ATOM 1256 ND2 ASN 168 117, .433 19 .499 21 .252 1 .00 45 .97 1SG1257
ATOM 1257 C ASN 168 116, .590 23 .652 21 .608 1 .00 45 .97 1SG1258
ATOM 1258 0 ASN 168 115, .375 23 .509 21, .730 1 .00 45 .97 1SG1259
ATOM 1259 N ARG 169 117, .328 24 .287 22 .530 1 .00 52 .88 1SG1260
ATOM 1260 CA ARG 169 116, .747 24 .763 23 .750 1 .00 52 .88 1SG1261
ATOM 1261 CB ARG 169 117. .790 25 .373 24. .704 1. .00 52, .88 1SG1262
ATOM 1262 CG ARG 169 117. .190 25 .884 26. .016 1, .00 52, .88 1SG1263
ATOM 1263 CD ARG 169 118. .229 26 .402 27. .015 1. .00 52. .88 1SG1264
ATOM 1264 NE ARG 169 118. .872 27 .606 26. .419 1. .00 52 .88 1SG1265
ATOM 1265 CZ ARG 169 120. .062 27 .490 25, .759 1. .00 52 .88 1SG1266
ATOM 1266 NHl ARG 169 120. .683 26 .278 25, .678 1 .00 52 .88 1SG1267
ATOM 1267 NH2 ARG 169 120. .634 28 .590 25, .187 1. .00 52 .88 1SG1268
ATOM 1268 C ARG 169 115. .717 25 .809 23, .446 1, .00 52 .88 1SG1269
ATOM 1269 0 ARG 169 114 , .697 25 .891 24, .125 1 .00 52 .88 1SG1270
ATOM 1270 N LYS 170 115. .957 26 .669 22 .442 1 .00 60 .81 1SG1271
ATOM 1271 CA LYS 170 114. .991 27 .693 22, .149 1 .00 60 .81 1SG1272
ATOM 1272 CB LYS 170 115, .481 28 .686 21, .080 1 .00 60 .81 1SG1273 ATOM 1273 CG LYS 170 116.645 29.567 21..543 1..00 60,.81 1SG1274
ATOM 1274 CD LYS 170 116 .314 30 .428 22, .765 1, .00 60, .81 1SG1275
ATOM 1275 CE LYS 170 117 .428 31 .402 23, .155 1, .00 60. .81 1SG1276
ATOM 1276 NZ LYS 170 118 .658 30 .659 23, .505 1, .00 60. .81 1SG1277
ATOM 1277 C LYS 170 113 .715 27 .079 21 .644 1 .00 60. .81 1SG1278
ATOM 1278 O LYS 170 112 .624 27. .454 22, .072 1, .00 60. .81 1SG1279
ATOM 1279 N TRP 171 113 .837 26 .080 20, .747 1 .00 71, .07 1SG1280
ATOM 1280 CA TRP 171 112 .745 25 .413 20 .088 1 .00 71, .07 1SG1281
ATOM 1281 CB TRP 171 113 .190 24 .316 19 .102 1 .00 71 .07 1SG1282
ATOM 1282 CG TRP 171 113 .737 24 .818 17, .786 1, .00 71, .07 1SG1283
ATOM 1283 CD2 TRP 171 112 .915 25 .043 16, .629 1, .00 71, .07 1SG1284
ATOM 1284 CDl TRP 171 115 .013 25 .130 17, .420 1 .00 71, .07 1SG1285
ATOM 1285 NE1 TRP 171 115 .038 25 .536 16 .105 1 .00 71, .07 1SG1286
ATOM 1286 CE2 TRP 171 113 .753 25 .487 15, .607 1, .00 71, .07 1SG1287
ATOM 1287 CE3 TRP 171 111 .572 24 .890 16, .436 1 .00 71. .07 1SG1288
ATOM 1288 CZ2 TRP 171 113 .256 25 .785 14 .370 1 .00 71. .07 1SG1289
ATOM 1289 CZ3 TRP 171 111 .074 25 .194 15 .189 1 .00 71 .07 1SG1290
ATOM 1290 CH2 TRP 171 111 .901 25 .634 14, .176 1, .00 71. .07 1SG1291
ATOM 1291 C TRP 171 111 .889 24 .767 21 .105 1 .00 71. .07 1SG1292
ATOM 1292 O TRP 171 110 .685 24 .610 20 .908 1 .00 71. .07 1SG1293
ATOM 1293 N THR 172 112. .463 24. .393 22, .262 1, .00 80. .11 1SG1294
ATOM 1294 CA THR 172 Ill .596 23 .904 23, .285 1 .00 80. .11 1SG1295
ATOM 1295 CB THR 172 112 .260 23 .095 24 .373 1 .00 80. .11 1SG1296
ATOM 1296 OGl THR 172 111 .269 22 .435 25 .147 1 .00 80 .11 1SG1297
ATOM 1297 CG2 THR 172 113. .111 23. .993 25, .280 1, .00 80, .11 1SG1298
ATOM 1298 C THR 172 110 .993 25, .159 23, .838 1, .00 80. .11 1SG1299
ATOM 1299 O THR 172 110 .753 26 .110 23 .112 1 .00 80. .11 1SG1300
ATOM 1300 N ASN 173 110 .591 25 .242 25 .101 1 .00 80, .82 1SG1301
ATOM 1301 CA ASN 173 109. .985 26, .479 25, .532 1, .00 80. .82 1SG1302
ATOM 1302 CB ASN 173 110. .864 27. .730 25, .317 1, .00 80. .82 1SG1303
ATOM 1303 CG ASN 173 Ill .960 27 .746 26 .374 1, .00 80, .82 1SG1304
ATOM 1304 ODl ASN 173 111 .859 27 .083 27, .405 1 .00 80, .82 1SG1305
ATOM 1305 ND2 ASN 173 113. .033 28. .542 26 , .120 1, .00 80. .82 1SG1306
ATOM 1306 C ASN 173 108. .673 26. .695 24, .815 1, .00 80, .82 1SG1307
ATOM 1307 O ASN 173 107. .955 27. .649 25, .107 1, .00 80, .82 1SG1308
ATOM 1308 N LEU 174 108. .295 25. .787 23. .892 1. .00 79. .25 1SG1309
ATOM 1309 CA LEU 174 107. .042 25. .830 23. .224 1, .00 79. .25 1SG1310
ATOM 1310 CB LEU 174 106, .866 24. .758 22. .135 1, .00 79. .25 1SG1311
ATOM 1311 CG LEU 174 107, .697 24, .920 20, .860 1. .00 79. .25 1SG1312
ATOM 1312 CD2 LEU 174 107. .357 26. .236 20. .150 1. .00 79. .25 1SG1313
ATOM 1313 CDl LEU 174 107. .492 23. .717 19. .929 1. .00 79. ,25 1SG1314
ATOM 1314 C LEU 174 106, .156 25. .340 24. .293 1. .00 79. ,25 1SG1315
ATOM 1315 O LEU 174 106, .553 24. .456 25. .052 1. .00 79. .25 1SG1316
ATOM 1316 N SER 175 104. .946 25. .894 24. .402 1. .00 72. .10 1SG1317
ATOM 1317 CA SER 175 104. .138 25. .382 25. .458 1. .00 72. ,10 1SG1318
ATOM 1318 CB SER 175 102. .959 26. .293 25. .833 1. .00 72. ,10 1SG1319
ATOM 1319 OG SER 175 103, .447 27, .519 26. .355 1. .00 72. .10 1SG1320
ATOM 1320 C SER 175 103. ,583 24. .063 25. .034 1. .00 72. .10 1SG1321
ATOM 1321 O SER 175 103. .009 23. .928 23. .954 1. .00 72. .10 1SG1322
ATOM 1322 N ASP 176 103. .748 23. .040 25. .892 1. .00 65. ,93 1SG1323
ATOM 1323 CA ASP 176 103. .137 21. .780 25. .594 1. .00 65. .93 1SG1324
ATOM 1324 CB ASP 176 104. .060 20. .554 25. .732 1. .00 65. 93 1SG1325
ATOM 1325 CG ASP 176 104. .839 20. ,391 24. ,436 1. ,00 65. 93 1SG1326
ATOM 1326 ODl ASP 176 104. .903 21. .365 23. .638 1. ,00 65. 93 1SG1327
ATOM 1327 OD2 ASP 176 105. .359 19. 265 24. .217 1. 00 65. 93 1SG1328
ATOM 1328 C ASP 176 101. .904 21. .706 26. .448 1. 00 65. 93 1SG1329
ATOM 1329 O ASP 176 100. .830 21. .861 25. .871 1. ,00 65. 93 1SG1330 ATOM 1330 N PRO 177 101..897 21..415 27..736 1.00 61.,73 1SG1331
ATOM 1331 CA PRO 177 100. .652 21. ,676 28. ,406 1. 00 61. .73 1SG1332
ATOM 1332 CD PRO 177 102. .508 20. .202 28. ,267 1. .00 61. .73 1SG1333
ATOM 1333 CB PRO 177 100. .481 20. .623 29. .502 1. ,00 61. .73 1SG1334
ATOM 1334 CG PRO 177 101. .877 20. ,003 29. .652 1. ,00 61. .73 1SG1335
ATOM 1335 C PRO 177 100. .672 23. .093 28. .883 1. ,00 61. .73 1SG1336
ATOM 1336 O PRO 177 101. .559 23. .434 29. .663 1. .00 61. .73 1SG1337
ATOM 1337 N MET 178 99. .691 23. .930 28. .503 1. .00 55. .00 1SG1338
ATOM 1338 CA MET 178 99, .765 25. .274 28. .990 1. .00 55. .00 1SG1339
ATOM 1339 CB MET 178 99. .860 26. .316 27. .864 1. .00 55. .00 1SG1340
ATOM 1340 CG MET 178 99. .957 27. .761 28. .349 1. .00 55, .00 1SG1341
ATOM 1341 SD MET 178 100. .507 28. .906 27. .052 1. ,00 55. .00 1SG1342
ATOM 1342 CE MET 178 99. .289 28. .280 25. .859 1. .00 55. .00 1SG1343
ATOM 1343 C MET 178 98. .550 25. .545 29. .815 1. .00 55. .00 1SG1344
ATOM 1344 O MET 178 97. .423 25. .535 29. .322 1. .00 55. .00 1SG1345
ATOM 1345 N PRO 179 98. .775 25. .729 31. .091 1. .00 49, .84 1SG1346
ATOM 1346 CA PRO 179 97. .679 26. .053 31. .964 1. .00 49, .84 1SG1347
ATOM 1347 CD PRO 179 99. .782 24. .927 31. .770 1. .00 49, .84 1SG1348
ATOM 1348 CB PRO 179 98. .154 25. .740 33. .381 1. .00 49, .84 1SG1349
ATOM 1349 CG PRO 179 99. .211 24. .642 33. .170 1. .00 49, .84 1SG1350
ATOM 1350 C PRO 179 97, .217 27, .466 31. .777 1. .00 49, .84 1SG1351
ATOM 1351 O PRO 179 98, .026 28, .380 31, .934 1. .00 49 .84 1SG1352
ATOM 1352 N VAL 180 95, .929 27, .661 31, .430 1, .00 43 .52 1SG1353
ATOM 1353 CA VAL 180 95, .345 28. .964 31. .269 1. .00 43 .52 1SG1354
ATOM 1354 CB VAL 180 94 .094 28, .939 30, .445 1. .00 43 .52 1SG1355
ATOM 1355 CGI VAL 180 93 .509 30. .361 30, .394 1. .00 43 .52 1SG1356
ATOM 1356 CG2 VAL 180 94, .438 28. .353 29, .066 1. .00 43, .52 1SG1357
ATOM 1357 C VAL 180 94. .996 29. .563 32, .590 1. .00 43, .52 1SG1358
ATOM 1358 O VAL 180 95. .176 30. .760 32 , .811 1. .00 43, .52 1SG1359
ATOM 1359 N GLY 181 94, .456 28. .731 33 , .502 1. .00 38 .65 1SG1360
ATOM 1360 CA GLY 181 94, .004 29. .234 34, .762 1. .00 38 .65 1SG1361
ATOM 1361 C GLY 181 93. .804 28. .064 35, .663 1, .00 38 .65 1SG1362
ATOM 1362 O GLY 181 94. .375 26. .996 35, .458 1, .00 38 .65 1SG1363
ATOM 1363 N GLN 182 92. .996 28, .256 36, .717 1. .00 38 .58 1SG1364
ATOM 1364 CA GLN 182 92. .768 27, .206 37, .658 1, .00 38 .58 1SG1365
ATOM 1365 CB GLN 182 91 .920 27, .679 38, .849 1, .00 38 .58 1SG1366
ATOM 1366 CG GLN 182 91 .642 26, .592 39, .888 1. .00 38 .58 1SG1367
ATOM 1367 CD GLN 182 90 .816 27, .225 40, .998 1. .00 38 .58 1SG1368
ATOM 1368 OEl GLN 182 90 .051 26, .554 41, .688 1. .00 38 .58 1SG1369
ATOM 1369 NE2 GLN 182 90 .978 28, .564 41. .178 1. .00 38 .58 1SG1370
ATOM 1370 C GLN 182 92 .048 26 .066 37. .001 1, .00 38 .58 1SG1371
ATOM 1371 O GLN 182 92. .391 24. .908 37, .235 1. .00 38, .58 1SG1372
ATOM 1372 N MET 183 90. .997 26. .365 36, .206 1. .00 40, .11 1SG1373
ATOM 1373 CA MET 183 90, .173 25. .354 35, .590 1. .00 40, .11 1SG1374
ATOM 1374 CB MET 183 88, .895 25, .939 34, .966 1. .00 40, .11 1SG1375
ATOM 1375 CG MET 183 87, .891 26, .493 35, .976 1. .00 40, .11 1SG1376
ATOM 1376 SD MET 183 86, .387 27. .181 35, .222 1. .00 40, .11 1SG1377
ATOM 1377 CE MET 183 85, .566 27. .483 36, .812 1. .00 40, .11 1SG1378
ATOM 1378 C MET 183 90, .811 24. .540 34, .494 1. .00 40, .11 1SG1379
ATOM 1379 O MET 183 90, .863 23. .315 34, .590 1. .00 40, .11 1SG1380
ATOM 1380 N GLY 184 91 .361 25, .175 33, .435 1. .00 46, .01 1SG1381
ATOM 1381 CA GLY 184 91 .745 24, .349 32, .319 1. .00 46. .01 1SG1382
ATOM 1382 C GLY 184 93 .119 24, .666 31, .824 1, .00 46, .01 1SG1383
ATOM 1383 O GLY 184 93 .767 25, .611 32, .268 1, .00 46 .01 1SG1384
ATOM 1384 N THR 185 93 .586 23, .820 30, .878 1, .00 54 .76 1SG1385
ATOM 1385 CA THR 185 94 .871 23, .910 30 .244 1. .00 54, .76 1SG1386
ATOM 1386 CB THR 185 95, .892 22. .994 30. .869 1. .00 54. .76 1SG1387 ATOM 1387 OGl THR 185 97..157 23..147 30..243 1..00 54..76 1SG1388
ATOM 1388 CG2 THR 185 95. .403 21. .538 30. .746 1. .00 54. .76 1SG1389
ATOM 1389 C THR 185 94. .677 23, .465 28, .826 1. ,00 54. .76 1SG1390
ATOM 1390 O THR 185 93. .631 22, .920 28. .479 1. ,00 54. .76 1SG1391
ATOM 1391 N VAL 186 95. .671 23. .710 27. .949 1. ,00 62. .71 1SG1392
ATOM 1392 CA VAL 186 95 .523 23 .241 26, .599 1. .00 62. .71 1SG1393
ATOM 1393 CB VAL 186 95. .359 24, .343 25 .594 1. .00 62, .71 1SG1394
ATOM 1394 CGI VAL 186 95 .278 23 .733 24, .184 1. .00 62, .71 1SG1395
ATOM 1395 CG2 VAL 186 94. .116 25, .159 25, .988 1. .00 62, .71 1SG1396
ATOM 1396 C VAL 186 96 .761 22 .490 26, .261 1. .00 62. .71 1SG1397
ATOM 1397 o VAL 186 97. .861 22, .931 26, .587 1. .00 62, .71 1SG1398
ATOM 1398 N LYS 187 96. .650 21 .310 25, .621 1. .00 71, .00 1SG1399
ATOM 1399 CA LYS 187 97. .929 20, .771 25, .293 1. .00 71, .00 1SG1400
ATOM 1400 CB LYS 187 98. .390 19, .409 25, .880 1. .00 71. .00 1SG1401
ATOM 1401 CG LYS 187 97 .343 18, .387 26. .310 1. ,00 71. .00 1ΞG1402
ATOM 1402 CD LYS 187 96. .718 18. .679 27. .677 1. .00 71. .00 1SG1403
ATOM 1403 CE LYS 187 96 .855 17 .510 28 .659 1. .00 71 .00 1SG1404
ATOM 1404 NZ LYS 187 96 .432 16. .253 27 .999 1. .00 71 .00 1SG1405
ATOM 1405 C LYS 187 98 .247 20 .870 23 .848 1, .00 71. .00 1SG1406
ATOM 1406 O LYS 187 97 .486 20, .448 22 .973 1, .00 71. .00 1SG1407
ATOM 1407 N TYR 188 99 .419 21 .494 23 .584 1. .00 73, .12 1SG1408
ATOM 1408 CA TYR 188 9 .845 21, .627 22 .227 1. .00 73 .12 1SG1409
ATOM 1409 CB TYR 188 100 .482 22, .969 21 .851 1. .00 73, .12 1SG1410
ATOM 1410 CG TYR 188 99 .605 24. .057 22. .315 1, .00 73 .12 1SG1411
ATOM 1411 CDl TYR 188 98, .375 24. .274 21 .746 1, .00 73, .12 1SG1412
ATOM 1412 CD2 TYR 188 100 .062 24. .871 23. .321 1. .00 73 .12 1SG1413
ATOM 1413 CE1 TYR 188 97, .590 25, .299 22 .208 1. .00 73, .12 1SG1414
ATOM 1414 CE2 TYR 188 99, .283 25. .896 23. .783 1. .00 73 .12 1SG1415
ATOM 1415 CZ TYR 188 98 .047 26. .102 23 .225 1. .00 73 .12 1SG1416
ATOM 1416 OH TYR 188 97 .241 27 .151 23 .699 1, .00 73 .12 1SG1417
ATOM 1417 C TYR 188 101 .007 20. .711 22 .045 1. .00 73 .12 1SG1418
ATOM 1418 O TYR 188 102 .028 21. .135 21 .506 1. .00 73 .12 1SG1419
ATOM 1419 N VAL 189 100 .899 19, .431 22 .436 1, .00 69 .47 1SG1420
ATOM 1420 CA VAL 189 102 .045 18. .583 22 .256 .00 69. .47 1SG1421
ATOM 1421 CB VAL 189 102, .071 17. .330 23 .101 1. .00 69 .47 1SG1422
ATOM 1422 CGI VAL 189 102 .053 17. .726 24 .585 1. .00 69. .47 1SG1423
ATOM 1423 CG2 VAL 189 100, .933 16, .388 22, .686 1. .00 69 .47 1SG1424
ATOM 1424 C VAL 189 102, .112 18, .162 20, .823 1. .00 69, .47 1SG1425
ATOM 1425 O VAL 189 101, .085 17. .971 20. .172 1. .00 69, .47 1SG1426
ATOM 1426 N LEU 190 103 .349 18 .024 20 .294 1, .00 62 .17 1SG1427
ATOM 1427 CA LEU 190 103 .552 17. .599 18 .934 1. .00 62 .17 1SG1428
ATOM 1428 CB LEU 190 105, .032 17. .509 18 .520 1. .00 62, .17 1SG1429
ATOM 1429 CG LEU 190 105 .775 18, .838 18. .316 1. .00 62, .17 1SG1430
ATOM 1430 CD2 LEU 190 107, .205 18, .563 17 .822 1, .00 62, .17 1SG1431
ATOM 1431 CDl LEU 190 105, .751 19, .722 19. .572 1. .00 62. .17 1SG1432
ATOM 1432 C LEU 190 103, .061 16. .197 18, .809 1. .00 62. .17 1SG1433
ATOM 1433 O LEU 190 103, .454 15, .320 19, .578 1. .00 62. .17 1SG1434
ATOM 1434 N MET 191 102, .150 15, .976 17, .844 1. .00 53. .07 1SG1435
ATOM 1435 CA MET 191 101. .604 14, .687 17, .539 1. .00 53. .07 1SG1436
ATOM 1436 CB MET 191 100. .316 14. .740 16, .709 1. .00 53. .07 1SG1437
ATOM 1437 CG MET 191 99. .498 13, .458 16 .866 1. .00 53, .07 1SG1438
ATOM 1438 SD MET 191 98 .367 13, .100 15, .497 1. .00 53, .07 1SG1439
ATOM 1439 CE MET 191 99. .682 12. .281 14 .552 1. .00 53, .07 1SG1440
ATOM 1440 C MET 191 102. .574 13. .850 16, .764 1. .00 53. .07 1SG1441
ATOM 1441 O MET 191 102, .530 12. .625 16, .853 1. .00 53. .07 1SG1442
ATOM 1442 N SER 192 103 , .419 14. .482 15, .918 1. .00 44. .22 1SG1443
ATOM 1443 CA SER 192 104. .337 13. .731 15. .103 1. .00 44. .22 1SG1444 > > >> > > > > > > > p > > > > >
H H H H H H H H H
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ATOM 1501 O TYR 200 107..149 22.,709 5.,018 1.00 52.,02 1SG1502
ATOM 1502 N ILE 201 107. ,135 24. ,281 6. .653 1. 00 53. ,33 1SG1503
ATOM 1503 CA ILE 201 107. .529 23. .348 7. .667 1. .00 53. .33 1SG1504
ATOM 1504 CB ILE 201 108. .511 23. .918 8. .648 1. .00 53. .33 1SG1505
ATOM 1505 CG2 ILE 201 108. .732 22. ,869 9. .750 1. .00 53. ,33 1SG1506
ATOM 1506 CGI ILE 201 109. .801 24. .372 7. .941 1. .00 53. .33 1SG1507
ATOM 1507 CDl ILE 201 110. .546 23. .250 7, .220 1. ,00 53. .33 1SG1508
ATOM 1508 C ILE 201 106. .270 23. .106 8. .434 1. .00 53. .33 1SG1509
ATOM 1509 O ILE 201 105. .712 24. .023 9. .032 1. .00 53. .33 1SG1510
ATOM 1510 N GLN 202 105. .759 21. .865 8. .432 1. .00 52. .31 1SG1511
ATOM 1511 CA GLN 202 104. .520 21. .676 9, .126 1. .00 52. .31 1SG1512
ATOM 1512 CB GLN 202 103. .525 20. .701 8. .475 1. .00 52. .31 1SG1513
ATOM 1513 CG GLN 202 102. .742 21. .243 7. .283 1. .00 52. .31 1SG1514
ATOM 1514 CD GLN 202 101. .619 20. .247 7. .025 1. .00 52. .31 1SG1515
ATOM 1515 OEl GLN 202 101. .664 19. .112 7, .500 1. .00 52. .31 1SG1516
ATOM 1516 NE2 GLN 202 100. .577 20. .680 6. .266 1. .00 52. .31 1SG1517
ATOM 1517 C GLN 202 104. .759 21. .119 10. .485 1. .00 52. .31 1SG1518
ATOM 1518 O GLN 202 105, .581 20. .225 10 .679 1, .00 52. .31 1SG1519
ATOM 1519 N LEU 203 104. .024 21. .657 11, .477 1. .00 54. .56 1SG1520
ATOM 1520 CA LEU 203 104. .115 21. .108 12, .793 1. .00 54, .56 1SG1521
ATOM 1521 CB LEU 203 104. .670 22. .075 13, .857 1. .00 54, .56 1SG1522
ATOM 1522 CG LEU 203 106. .133 22. .503 13 .619 1, .00 54 .56 1SG1523
ATOM 1523 CD2 LEU 203 106. .746 23. .139 14 .877 1. .00 54, .56 1SG1524
ATOM 1524 CDl LEU 203 106. .260 23, .396 12, .374 1. .00 54, .56 1SG1525
ATOM 1525 C LEU 203 102. .730 20, .719 13 .215 1. .00 54 .56 1SG1526
ATOM 1526 O LEU 203 101. .805 21, .533 13 .171 1. .00 54 .56 1SG1527
ATOM 1527 N ASP 204 102 , .566 19, .443 13 .631 1. .00 63 .65 1SG1528
ATOM 1528 CA ASP 204 101. .312 18. .925 14, .113 1. .00 63. .65 1SG1529
ATOM 1529 CB ASP 204 101. .190 17. .395 14 .131 1. .00 63 .65 1SG1530
ATOM 1530 CG ASP 204 100, .978 16. .862 12 .744 1. .00 63 .65 1SG1531
ATOM 1531 ODl ASP 204 100. .263 17. .544 11 .958 1. .00 63 .65 1SG1532
ATOM 1532 OD2 ASP 204 101, .509 15, .763 12, .457 1. .00 63 .65 1SG1533
ATOM 1533 C ASP 204 101, .275 19, .179 15 .573 1. .00 63 .65 1SG1534
ATOM 1534 O ASP 204 102, .228 18, .869 16 .285 1, .00 63 .65 1SG1535
ATOM 1535 N PHE 205 100, .140 19, .701 16 .058 1. .00 77 .41 1SG1536
ATOM 1536 CA PHE 205 99. .949 19, .972 17, .447 1. .00 77. .41 1SG1537
ATOM 1537 CB PHE 205 99. .625 21. .457 17 .706 1. .00 77 .41 1SG1538
ATOM 1538 CG PHE 205 100. .873 22, .273 17 .730 1, .00 77 .41 1SG1539
ATOM 1539 CDl PHE 205 101. .805 22. .174 16 .727 1. .00 77. .41 1SG1540
ATOM 1540 CD2 PHE 205 101, .134 23. .104 18 .799 1. .00 77 .41 1SG1541
ATOM 1541 CE1 PHE 205 102, .958 22. .920 16 .766 1, .00 77 .41 1SG1542
ATOM 1542 CE2 PHE 205 102, .286 23, .857 18 .843 1, .00 77, .41 1SG1543
ATOM 1543 CZ PHE 205 103. .200 23, .766 17, .820 1. .00 77, .41 1SG1544
ATOM 1544 C PHE 205 98. .736 19, .231 17 .876 1. .00 77 .41 1SG1545
ATOM 1545 O PHE 205 97, .811 18, .976 17 .103 1, .00 77, .41 1SG1546
ATOM 1546 N SER 206 98, .702 18, .913 19 .175 1. .00 90, .68 1SG1547
ATOM 1547 CA SER 206 97. .575 18. .267 19 .749 1. .00 90, .68 1SG1548
ATOM 1548 CB SER 206 97. .851 17, .764 21 .179 1. .00 90 .68 1SG1549
ATOM 1549 OG SER 206 98, .652 16, .596 21 .119 1. .00 90 .68 1SG1550
ATOM 1550 C SER 206 96, .497 19, .284 19 .748 1. .00 90, .68 1SG1551
ATOM 1551 O SER 206 96. .365 20. .131 18 .872 1. .00 90, .68 1SG1552
ATOM 1552 N PRO 207 95. .582 19. .208 20 .586 1, .00 95, .77 1SG1553
ATOM 1553 CA PRO 207 94, .690 20. .202 20 .114 1. .00 95, .77 1SG1554
ATOM 1554 CD PRO 207 94. .901 17, .913 20 .634 1. .00 95, .77 1SG1555
ATOM 1555 CB PRO 207 93, .640 19, .450 19 .320 1. .00 95 .77 1SG1556
ATOM 1556 CG PRO 207 93 , .485 18, .146 20 .100 1, .00 95, .77 1SG1557
ATOM 1557 C PRO 207 93. .924 20. .967 21 .059 1. .00 95, .77 1SG1558 ATOM 1558 O PRO 207 93.,403 22..017 20..685 1.00 95.,77 1SG1559
ATOM 1559 N VAL 208 93. ,625 20. .279 22. ,162 1. ,00 85. ,67 1SG1560
ATOM 1560 CA VAL 208 92. ,509 20. .780 22. ,858 1. .00 85. ,67 1SG1561
ATOM 1561 CB VAL 208 91. ,305 19. .898 22. ,716 1. .00 85. .67 1SG1562
ATOM 1562 CGI VAL 208 90. .878 19. .877 21. ,238 1. .00 85. .67 1SG1563
ATOM 1563 CG2 VAL 208 91. ,652 18. .512 23. .282 1. ,00 85. .67 1SG1564
ATOM 1564 C VAL 208 92. ,739 20. .979 24. .293 1. ,00 85. .67 1SG1565
ATOM 1565 o VAL 208 93. .744 20. .580 24. .880 1. ,00 85. .67 1SG1566
ATOM 1566 N VAL 209 91. .739 21. .659 24. .866 1. ,00 68. .51 1SG1567
ATOM 1567 CA VAL 209 91. .721 21. .996 26. .242 1. .00 68. .51 1SG1568
ATOM 1568 CB VAL 209 90. ,617 22. .952 26. .595 1. ,00 68. .51 1SG1569
ATOM 1569 CGI VAL 209 90, .604 23. .151 28. .120 1. .00 68, .51 1SG1570
ATOM 1570 CG2 VAL 209 90. .805 24. .246 25, .787 1. .00 68, .51 1SG1571
ATOM 1571 C VAL 209 91. .463 20 .747 27, .007 1. .00 68, .51 1SG1572
ATOM 1572 0 VAL 209 90. .684 19, .894 26, .584 1. .00 68, .51 1SG1573
ATOM 1573 N GLN 210 92. .145 20, .606 28, .157 1. .00 51, .55 1SG1574
ATOM 1574 CA GLN 210 91, .896 19 .476 28, .998 1. .00 51, .55 1SG1575
ATOM 1575 CB GLN 210 93, .056 18 .471 29, .120 1. .00 51, .55 1SG1576
ATOM 1576 CG GLN 210 92, .665 17 .239 29, .945 1, .00 51, .55 1SG1577
ATOM 1577 CD GLN 210 93, .852 16 .290 30, .021 1. .00 51, .55 1SG1578
ATOM 1578 OEl GLN 210 94, .933 16 .655 30, .478 1. .00 51 .55 1SG1579
ATOM 1579 NE2 GLN 210 93, .644 15 .028 29, .560 1. .00 51 .55 1SG1580
ATOM 1580 C GLN 210 91, .625 20 .020 30, .364 1. .00 51, .55 1SG1581
ATOM 1581 0 GLN 210 91, .858 21 .200 30, .630 1. .00 51 .55 1SG1582
ATOM 1582 N GLN 211 91, .085 19 .175 31 .263 1. .00 37 .15 1SG1583
ATOM 1583 CA GLN 211 90, .788 19 .629 32, .591 1. .00 37, .15 1SG1584
ATOM 1584 CB GLN 211 89, .292 19 .544 32 .942 1. .00 37 .15 1SG1585
ATOM 1585 CG GLN 211 88, .951 20 .064 34 .339 1. .00 37 .15 1SG1586
ATOM 1586 CD GLN 211 87, .447 19 .919 34, .527 1. .00 37, .15 1SG1587
ATOM 1587 OEl GLN 211 86, .798 19 .144 33, .827 1 , .00 37 .15 1SG1588
ATOM 1588 NE2 GLN 211 86, .876 20 .686 35, .494 1, .00 37, .15 1SG1589
ATOM 1589 C GLN 211 91, .529 18 .754 33 .550 1, .00 37 .15 1SG1590
ATOM 1590 O GLN 211 91, .602 17 .539 33, .372 1. .00 37, .15 1SG1591
ATOM 1591 N GLN 212 92. .143 19 .379 34, .572 1. .00 31, .28 1SG1592
ATOM 1592 CA GLN 212 92. .883 18, .684 35, .585 1, .00 31, .28 1SG1593
ATOM 1593 CB GLN 212 93. .696 19, .645 36, .470 1. .00 31, .28 1SG1594
ATOM 1594 CG GLN 212 94. .811 20, .371 35, .712 1. .00 31, .28 1SG1595
ATOM 1595 CD GLN 212 95. .489 21, .334 36, .676 1. .00 31, .28 1SG1596
ATOM 1596 OEl GLN 212 94, .839 22 .199 37, .261 1. .00 31, .28 1SG1597
ATOM 1597 NE2 GLN 212 96, .829 21, .182 36, .852 1. .00 31, .28 1SG1598
ATOM 1598 C GLN 212 91, .951 17, .923 36, .481 1. .00 31, .28 1SG1599
ATOM 1599 O GLN 212 92, .238 16, .789 36, .864 1. .00 31, .28 1SG1600
ATOM 1600 N LYS 213 90, .801 18, .530 36, .842 1. .00 30, .99 1SG1601
ATOM 1601 CA LYS 213 89, .912 17, .906 37, .783 1. .00 30. .99 1SG1602
ATOM 1602 CB LYS 213 88. .659 18, .747 38, .092 1. .00 30. .99 1SG1603
ATOM 1603 CG LYS 213 88. .923 19, .968 38, .978 1. .00 30, .99 1SG1604
ATOM 1604 CD LYS 213 89. .753 21, .064 38, .308 1. .00 30, .99 1SG1605
ATOM 1605 CE LYS 213 89. .958 22, .299 39, .189 1. .00 30. .99 1SG1606
ATOM 1606 NZ LYS 213 90. .958 22, .014 40, .243 1. .00 30, .99 1SG1607
ATOM 1607 C LYS 213 89. .442 16, .594 37. .248 1. .00 30. .99 1SG1608
ATOM 1608 O LYS 213 89. .475 15, .589 37. .955 1. .00 30. .99 1SG1609
ATOM 1609 N GLY 214 89. .001 16, .554 35, .978 1. .00 30. .91 1SG1610
ATOM 1610 CA GLY 214 88. .542 15, .302 35, .453 1. ,00 30. .91 1SG1611
ATOM 1611 C GLY 214 88. .912 15, .264 34, .010 1. ,00 30, .91 1SG1612
ATOM 1612 O GLY 214 88. .913 16, .290 33. .332 1. ,00 30. .91 1SG1613
ATOM 1613 N LYS 215 89. .224 14, .061 33. .495 1. ,00 34. .30 1SG1614
ATOM 1614 CA LYS 215 89, .624 13 .960 32. .124 1. .00 34. .30 1SG1615 ATOM 1615 CB LYS 215 90..820 13.013 31..918 1..00 34..30 1SG1616
ATOM 1616 CG LYS 215 91, .428 13, .041 30. .513 1. .00 34. .30 1SG1617
ATOM 1617 CD LYS 215 90. .498 12 .539 29. .408 1. .00 34. .30 1SG1618
ATOM 1618 CE LYS 215 91. .136 12 .582 28 .019 1. .00 34. .30 1SG1619
ATOM 1619 NZ LYS 215 92. .349 11 .734 27 .999 1, .00 34. .30 1SG1620
ATOM 1620 C LYS 215 88. .466 13 .424 31, .350 1. .00 34. .30 1SG1621
ATOM 1621 O LYS 215 87. .858 12 .423 31 .725 1, .00 34. .30 1SG1622
ATOM 1622 N THR 216 88, .126 14 .107 30 .241 1. .00 36. .11 1SG1623
ATOM 1623 CA THR 216 87, .044 13 .676 29 .410 1, .00 36. .11 1SG1624
ATOM 1624 CB THR 216 85, .834 14 .554 29 .513 1. .00 36. .11 1SG1625
ATOM 1625 OGl THR 216 86. .140 15 .861 29 .048 1. .00 36, .11 1SG1626
ATOM 1626 CG2 THR 216 85, .388 14 .610 30 .984 1. .00 36, .11 1SG1627
ATOM 1627 C THR 216 87, .519 13 .779 27 .999 1, .00 36. .11 1SG1628
ATOM 1628 O THR 216 88, .375 14 .603 27 .679 1. .00 36. .11 1SG1629
ATOM 1629 N ILE 217 86. .958 12 .940 27 .111 1. .00 36. .90 1SG1630
ATOM 1630 CA ILE 217 87, .345 12 .967 25 .733 1. .00 36. .90 1SG1631
ATOM 1631 CB ILE 217 87, .505 11 .607 25 .119 1, .00 36, .90 1SG1632
ATOM 1632 CG2 ILE 217 87, .734 11 .802 23 .611 1. .00 36, .90 1SG1633
ATOM 1633 CGI ILE 217 88, .635 10 .831 25 .816 1. .00 36, .90 1SG1634
ATOM 1634 CDl ILE 217 88, .329 10 .473 27 .270 1, .00 36, .90 1SG1635
ATOM 1635 C ILE 217 86, .239 13 .651 25 .007 1. .00 36, .90 1SG1636
ATOM 1636 O ILE 217 85, .066 13 .450 25 .320 1. .00 36, .90 1SG1637
ATOM 1637 N LYS 218 86, .585 14 .507 24 .028 1, .00 39, .94 1SG1638
ATOM 1638 CA LYS 218 85. .540 15 .220 23 .362 1. .00 39, .94 1SG1639
ATOM 1639 CB LYS 218 86, .049 16 .227 22 .319 1. .00 39, .94 1SG1640
ATOM 1640 CG LYS 218 86, .964 17 .266 22 .969 1, .00 39. .94 1SG1641
ATOM 1641 CD LYS 218 86. .326 17 .947 24 .183 1, .00 39. .94 1SG1642
ATOM 1642 CE LYS 218 87, .328 18 .693 25 .067 1. .00 39. .94 1SG1643
ATOM 1643 NZ LYS 218 86, .662 19 .170 26 .300 1. .00 39. .94 1SG1644
ATOM 1644 C LYS 218 84, .644 14 .219 22 .719 1, .00 39, .94 1SG1645
ATOM 1645 O LYS 218 85, .100 13 .239 22 .133 1. .00 39, .94 1SG1646
ATOM 1646 N LEU 219 83, .322 14 .443 22 .845 1. .00 40, .01 1SG1647
ATOM 1647 CA LEU 219 82, .377 13, .487 22 .355 1. .00 40, .01 1SG1648
ATOM 1648 CB LEU 219 80, .920 13, .934 22 .612 1, .00 40, .01 1SG1649
ATOM 1649 CG LEU 219 79. .802 12, .900 22 .328 1, .00 40, .01 1SG1650
ATOM 1650 CD2 LEU 219 79. .845 12, .312 20 .908 1, .00 40, .01 1SG1651
ATOM 1651 CDl LEU 219 78, .426 13, .506 22 .643 1, .00 40, .01 1SG1652
ATOM 1652 C LEU 219 82, .579 13, .368 20 .884 1. .00 40, .01 1SG1653
ATOM 1653 O LEU 219 82. .743 12 .264 20 .367 1. .00 40, .01 1SG1654
ATOM 1654 N ALA 220 82. .587 14, .502 20 .159 1. .00 41. .17 1SG1655
ATOM 1655 CA ALA 220 82, .756 14, .353 18 .744 1. .00 41. .17 1SG1656
ATOM 1656 CB ALA 220 82. .692 15, .692 17, .991 1. .00 41. .17 1SG1657
ATOM 1657 C ALA 220 84. .117 13, .785 18, .542 1. .00 41. .17 1SG1658
ATOM 1658 O ALA 220 84. .310 12, .797 17, .835 1. .00 41. .17 1SG1659
ATOM 1659 N ASP 221 85. .090 14. .411 19, .219 1. .00 41. .26 1SG1660
ATOM 1660 CA ASP 221 86. .461 14. .014 19, .260 1. .00 41. .26 1SG1661
ATOM 1661 CB ASP 221 86. .661 12. .651 19, .953 1. .00 41. .26 1SG1662
ATOM 1662 CG ASP 221 88. .128 12. .498 20, .341 1. .00 41. .26 1SG1663
ATOM 1663 ODl ASP 221 88. .912 13. .454 20, .095 1. .00 41. .26 1SG1664
ATOM 1664 OD2 ASP 221 88. .482 11. .420 20, .887 1. .00 41. .26 1SG1665
ATOM 1665 C ASP 221 87. .070 13. .943 17, .893 1. .00 41. .26 1SG1666
ATOM 1666 O ASP 221 88. ,070 13. .255 17, .709 1. .00 41. .26 1SG1667
ATOM 1667 N ALA 222 86. ,554 14. .664 16. .883 1. ,00 37. .16 1SG1668
ATOM 1668 CA ALA 222 87. ,243 14. .488 15. .637 1. ,00 37. .16 1SG1669
ATOM 1669 CB ALA 222 86. ,370 13. .851 14. .542 1. ,00 37. ,16 1SG1670
ATOM 1670 C ALA 222 87. .689 15. .816 15. .121 1. ,00 37. ,16 1SG1671
ATOM 1671 O ALA 222 86. ,868 16. .696 14. .874 1. ,00 37. ,16 1SG1672 ι ι 3H to > > > 5;' to ι >< ι H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ooddPPPddOdddddddddoopddddpPddddpppdOddPPddddPPdddddddOdd
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0i ui 4* uJ tθ H θ iΛ 00 si σι ui ιf* ω tθ H θ vD ∞ s] σι ui 4* uj t0 H θ VD 00 s cn ui ιt* UJ t H o vD 00 s] m ui ιt* -J t0 H θ v0 ∞ si σι ιn ιt* uJ t H θ
ATOM 1786 O GLN 238 96..014 29,.107 11..797 1..00 41..22 1SG1787
ATOM 1787 N LEU 239 96. .454 26, .913 12. .130 1. .00 44. .69 1SG1788
ATOM 1788 CA LEU 239 95. .128 26, .494 11. .798 1. .00 44. .69 1SG1789
ATOM 1789 CB LEU 239 95. .093 25. .303 10. .829 1. .00 44. .69 1SG1790
ATOM 1790 CG LEU 239 95. .616 25. .642 9. .421 1. .00 44, .69 1SG1791
ATOM 1791 CD2 LEU 239 97. .075 26. .122 9. .470 1. .00 44, .69 1SG1792
ATOM 1792 CDl LEU 239 94. .686 26, .634 8. .704 1. .00 44. .69 1SG1793
ATOM 1793 C LEU 239 94. .505 26, .063 13, .082 1. .00 44. .69 1SG1794
ATOM 1794 O LEU 239 94. .861 25, .028 13. .648 1. .00 44, .69 1SG1795
ATOM 1795 N LEU 240 93. .549 26, .869 13. .578 1. .00 46, .92 1SG1796
ATOM 1796 CA LEU 240 92. .915 26, .558 14. .821 1. .00 46, .92 1SG1797
ATOM 1797 CB LEU 240 92. .675 27, .818 15. .667 1, .00 46, .92 1SG1798
ATOM 1798 CG LEU 240 93. .983 28, .559 16. .013 1. .00 46. .92 1SG1799
ATOM 1799 CD2 LEU 240 95. .002 27, .621 16. .680 1. .00 46, .92 1SG1800
ATOM 1800 CDl LEU 240 93, .709 29, .812 16. .854 1, .00 46, .92 1SG1801
ATOM 1801 C LEU 240 91. .593 25, .954 14. .482 1. .00 46, .92 1SG1802
ATOM 1802 O LEU 240 90. .661 26 .645 14, .076 1. .00 46 .92 1SG1803
ATOM 1803 N LEU 241 91. .483 24, .629 14, .665 1. .00 49, .01 1SG1804
ATOM 1804 CA LEU 241 90, .306 23 .899 14 .301 1 .00 49 .01 1SG1805
ATOM 1805 CB LEU 241 90, .523 22, .382 14, .344 1 .00 49 .01 1SG1806
ATOM 1806 CG LEU 241 89. .285 21, .573 13, .931 1. .00 49, .01 1SG1807
ATOM 1807 CD2 LEU 241 89, .362 20 .137 14 .452 1 .00 49 .01 1SG1808
ATOM 1808 CDl LEU 241 89, .048 21, .652 12, .418 1 .00 49 .01 1SG1809
ATOM 1809 C LEU 241 89. .214 24, .206 15, .273 1. .00 49 .01 1SG1810
ATOM 1810 O LEU 241 89. .441 24 .664 16 .388 1 .00 49 .01 1SG1811
ATOM 1811 N PRO 242 88. .010 24 .005 14, .828 1 .00 49 .44 1SG1812
ATOM 1812 CA PRO 242 86. .893 24, .179 15, .700 1. .00 49 .44 1SG1813
ATOM 1813 CD PRO 242 87, .672 24 .406 13 .484 1 .00 49 .44 1SG1814
ATOM 1814 CB PRO 242 85, .657 24, .108 14, .813 1 .00 49 .44 1SG1815
ATOM 1815 CG PRO 242 86. .162 24, .703 13, .489 1. .00 49 .44 1SG1816
ATOM 1816 C PRO 242 86, .947 23 .184 16 .803 1 .00 49 .44 1SG1817
ATOM 1817 O PRO 242 86, .394 23. .456 17 .865 1 .00 49 .44 1SG1818
ATOM 1818 N ALA 243 87. .608 22, .033 16, .590 1. .00 47, .46 1SG1819
ATOM 1819 CA ALA 243 87. .671 21 .060 17 .635 1 .00 47 .46 1SG1820
ATOM 1820 CB ALA 243 88. .479 19, .811 17, .247 1, .00 47 .46 1SG1821
ATOM 1821 C ALA 243 88. .374 21 .718 18 .775 1, .00 47 .46 1SG1822
ATOM 1822 O ALA 243 87, .969 21 .582 19 .929 1 .00 47 .46 1SG1823
ATOM 1823 N THR 244 89, .438 22, .487 18. .469 1, .00 46, .36 1SG1824
ATOM 1824 CA THR 244 90, .170 23 .098 19 .533 1 .00 46 .36 1SG1825
ATOM 1825 CB THR 244 91, .326 23 .952 19. .092 1, .00 46, .36 1SG1826
ATOM 1826 OGl THR 244 90. .867 25, .141 18, .471 1, .00 46, .36 1SG1827
ATOM 1827 CG2 THR 244 92, .188 23 .140 18 .111 1 .00 46 .36 1SG1828
ATOM 1828 C THR 244 89, .240 23, .990 20, .298 1, .00 46, .36 1SG1829
ATOM 1829 O THR 244 89. .214 23. .952 21, .527 1, .00 46, .36 1SG1830
ATOM 1830 N PHE 245 88. .440 24. .807 19, .585 1, .00 43, .13 1SG1831
ATOM 1831 CA PHE 245 87, .543 25, .738 20, .220 1, .00 43 , .13 1SG1832
ATOM 1832 CB PHE 245 86. .817 26. .664 19. .227 1, .00 43. .13 1SG1833
ATOM 1833 CG PHE 245 87. .802 27. .629 18, .657 1, .00 43. .13 1SG1834
ATOM 1834 CDl PHE 245 88. .183 28. .741 19, .373 1. .00 43. .13 1SG1835
ATOM 1835 CD2 PHE 245 88. .333 27. .435 17, .403 1, .00 43. .13 1SG1836
ATOM 1836 CE1 PHE 245 89. .086 29. .638 18. .853 1, .00 43. .13 1SG1837
ATOM 1837 CE2 PHE 245 89. .237 28, .329 16. .877 1, .00 43. .13 1SG1838
ATOM 1838 CZ PHE 245 89, .616 29, .433 17. .602 1, .00 43. .13 1SG1839
ATOM 1839 C PHE 245 86. .480 25, .015 20. .994 1, .00 43. .13 1SG1840
ATOM 1840 O PHE 245 86. .147 25. .414 22. .108 1, .00 43. .13 1SG1841
ATOM 1841 N LEU 246 85. .906 23. .940 20. .419 1, .00 40, .19 1SG1842
ATOM 1842 CA LEU 246 84. .837 23. .224 21. .064 1, .00 40. .19 1SG1843 ATOM 1843 CB LEU 246 84..220 22.102 20..204 1..00 40,.19 1SG1844
ATOM 1844 CG LEU 246 83, .154 22. .554 19. .181 1. .00 40, .19 1SG1845
ATOM 1845 CD2 LEU 246 82, .527 21. .335 18. .486 1. .00 40, .19 1SG1846
ATOM 1846 CDl LEU 246 83, .681 23, .586 18. .176 1. .00 40, .19 1SG1847
ATOM 1847 C LEU 246 85, .297 22, .595 22. .341 1. .00 40, .19 1SG1848
ATOM 1848 O LEU 246 84, .539 22, .543 23. .307 1. ,00 40, .19 1SG1849
ATOM 1849 N SER 247 86, .541 22, .087 22. .388 1. ,00 37, .15 1SG1850
ATOM 1850 CA SER 247 86 .989 21 .415 23, .575 1. .00 37 .15 1SG1851
ATOM 1851 CB SER 247 88 .431 20 .896 23, .447 1. .00 37 .15 1SG1852
ATOM 1852 OG SER 247 89 .328 21 .985 23, .286 1. .00 37 .15 1SG1853
ATOM 1853 C SER 247 86 .956 22 .363 24, .732 1. .00 37 .15 1SG1854
ATOM 1854 O SER 247 86, .735 21 .954 25, .871 1. .00 37, .15 1SG1855
ATOM 1855 N ALA 248 87, .192 23 .661 24, .474 1. .00 33, .42 1SG1856
ATOM 1856 CA ALA 248 87, .206 24, .622 25, .538 1. .00 33, .42 1SG1857
ATOM 1857 CB ALA 248 87, .578 26, .033 25. .052 1. .00 33, .42 1SG1858
ATOM 1858 C ALA 248 85 .852 24 .708 26 .166 1. .00 33 .42 1SG1859
ATOM 1859 O ALA 248 85 .726 24 .741 27. .389 1, .00 33 .42 1SG1860
ATOM 1860 N GLU 249 84 .796 24 .736 25. .335 1. .00 31 .51 1SG1861
ATOM 1861 CA GLU 249 83 .459 24 .897 25, .823 1. .00 31 .51 1SG1862
ATOM 1862 CB GLU 249 82, .462 25 .074 24, .666 1. .00 31 .51 1SG1863
ATOM 1863 CG GLU 249 82, .708 26 .400 23, .936 1. .00 31 .51 1SG1864
ATOM 1864 CD GLU 249 81, .920 26, .430 22. .635 1. .00 31 .51 1SG1865
ATOM 1865 OEl GLU 249 82 .146 25 .526 21, .786 1. .00 31 .51 1SG1866
ATOM 1866 OE2 GLU 249 81 .082 27 .356 22 .473 1. .00 31 .51 1SG1867
ATOM 1867 C GLU 249 83 .086 23 .721 26, .669 1, .00 31 .51 1SG1868
ATOM 1868 O GLU 249 82 .436 23 .877 27, .702 1, .00 31 .51 1SG1869
ATOM 1869 N LEU 250 83, .490 22 .508 26, .252 1. .00 31 .23 1SG1870
ATOM 1870 CA LEU 250 83, .156 21 .324 26, .988 1. .00 31 .23 1SG1871
ATOM 1871 CB LEU 250 83, .623 20, .042 26, .279 1. .00 31 .23 1SG1872
ATOM 1872 CG LEU 250 83, .280 18, .748 27, .039 1. .00 31 .23 1SG1873
ATOM 1873 CD2 LEU 250 83 .988 17 .533 26 .416 1. .00 31 .23 1SG1874
ATOM 1874 CDl LEU 250 81 .763 18 .553 27, .160 1. .00 31 .23 1SG1875
ATOM 1875 C LEU 250 83 .812 21 .359 28, .335 1. .00 31 .23 1SG1876
ATOM 1876 O LEU 250 83, .176 21 .069 29, .348 1. .00 31 .23 1SG1877
ATOM 1877 N ALA 251 85, .108 21 .722 28. .383 1. .00 32 .68 1SG1878
ATOM 1878 CA ALA 251 85, .840 21, .715 29. .620 1. .00 32 .68 1SG1879
ATOM 1879 CB ALA 251 87, .325 22, .074 29. .433 1. .00 32 .68 1SG1880
ATOM 1880 C ALA 251 85, .261 22, .707 30. .579 1. .00 32, .68 1SG1881
ATOM 1881 O ALA 251 85 .130 22 .427 31. .770 1. .00 32 .68 1SG1882
ATOM 1882 N LEU 252 84, .916 23 .908 30. .084 1. .00 37 .46 1SG1883
ATOM 1883 CA LEU 252 84, .379 24, .942 30. .921 1. .00 37, .46 1SG1884
ATOM 1884 CB LEU 252 84, .237 26 .282 30. .180 1. .00 37, .46 1SG1885
ATOM 1885 CG LEU 252 85, .586 26, .845 29. .693 1. ,00 37, .46 1SG1886
ATOM 1886 CD2 LEU 252 86, .612 26, .910 30. .836 1. ,00 37, .46 1SG1887
ATOM 1887 CDl LEU 252 85. .408 28, .188 28. .968 1. ,00 37. .46 1SG1888
ATOM 1888 C LEU 252 83. .025 24 .533 31, .412 1. .00 37. .46 1SG1889
ATOM 1889 O LEU 252 82, .660 24 .813 32, .550 1. .00 37. .46 1SG1890
ATOM 1890 N LEU 253 82, .234 23, .866 30. .553 1. .00 43, .16 1SG1891
ATOM 1891 CA LEU 253 80, .899 23, .460 30. .892 1. ,00 43, .16 1SG1892
ATOM 1892 CB LEU 253 80. .223 22, .752 29. .697 1. ,00 43. .16 1SG1893
ATOM 1893 CG LEU 253 78. .834 22. .128 29. ,952 1. .00 43. .16 1SG1894
ATOM 1894 CD2 LEU 253 77. .875 23. .141 30. ,587 1. 00 43. .16 1SG1895
ATOM 1895 CDl LEU 253 78. .920 20. .819 30. ,755 1. 00 43. .16 1SG1896
ATOM 1896 C LEU 253 80. .947 22. .513 32. .045 1. ,00 43. .16 1SG1897
ATOM 1897 O LEU 253 80. .186 22. .649 33. .001 1. ,00 43. .16 1SG1898
ATOM 1898 N GLN 254 81. .867 21. .536 32. ,000 1. 00 50. .22 1SG1899
ATOM 1899 CA GLN 254 81. .913 20. .560 33. ,044 1. 00 50. ,22 1SG1900 ATOM 1900 CB GLN 254 83..024 19..520 32,.829 1,.00 50..22 1SG1901
ATOM 1901 CG GLN 254 82. .805 18. .686 31, .565 1. .00 50. .22 1SG1902
ATOM 1902 CD GLN 254 83. .951 17. .694 31, .436 1. .00 50. .22 1SG1903
ATOM 1903 OEl GLN 254 84. .297 17. .269 30, .334 1. .00 50, .22 1SG1904
ATOM 1904 NE2 GLN 254 84. .552 17. .306 32, .592 1. .00 50. .22 1SG1905
ATOM 1905 C GLN 254 82. .163 21. .281 34, .330 1, .00 50, .22 1SG1906
ATOM 1906 O GLN 254 81. .528 20. .985 35 .341 1 .00 50 .22 1SG1907
ATOM 1907 N LYS 255 83. .088 22. .259 34 .335 1. .00 56, .09 1SG1908
ATOM 1908 CA LYS 255 83. .239 23. .034 35 .532 1. .00 56, .09 1SG1909
ATOM 1909 CB LYS 255 84, .632 23. .668 35 .690 1, .00 56, .09 1SG1910
ATOM 1910 CG LYS 255 84, .788 24, .452 36 .994 1, .00 56, .09 1SG1911
ATOM 1911 CD LYS 255 84, .738 23, .565 38 .240 1, .00 56, .09 1SG1912
ATOM 1912 CE LYS 255 84, .874 24, .337 39 .553 1, .00 56, .09 1SG1913
ATOM 1913 NZ LYS 255 84. .775 23, .405 40, .699 1, .00 56, .09 1SG1914
ATOM 1914 C LYS 255 82. .253 24, .137 35, .332 1, .00 56. .09 1SG1915
ATOM 1915 o LYS 255 82. .607 25. .275 35, .033 1, .00 56, .09 1SG1916
ATOM 1916 N SER 256 80. .973 23. .802 35, .560 1, .00 55, .95 1SG1917
ATOM 1917 CA SER 256 79. .841 24. .601 35 .193 1 .00 55 .95 1SG1918
ATOM 1918 CB SER 256 78. .537 24. .152 35 .873 1 .00 55 .95 1SG1919
ATOM 1919 OG SER 256 78. .625 24, .349 37 .276 1 .00 55 .95 1SG1920
ATOM 1920 C SER 256 80. .007 26 .062 35 .445 1 .00 55 .95 1SG1921
ATOM 1921 O SER 256 80, .517 26, .487 36 .482 1 .00 55, .95 1SG1922
ATOM 1922 N PHE 257 79, .562 26, .868 34, .448 1, .00 52 .88 1SG1923
ATOM 1923 CA PHE 257 79, .552 28, .292 34, .581 1, .00 52, .88 1SG1924
ATOM 1924 CB PHE 257 80, .255 29, .079 33, .456 1, .00 52, .88 1SG1925
ATOM 1925 CG PHE 257 79. .511 28, .953 32, .176 1, .00 52, .88 1SG1926
ATOM 1926 CDl PHE 257 79. .647 27, .836 31, .387 1, .00 52, .88 1SG1927
ATOM 1927 CD2 PHE 257 78. .694 29. .978 31, .759 1, .00 52, .88 1SG1928
ATOM 1928 CE1 PHE 257 78. .960 27. .738 30 .201 1 .00 52 .88 1SG1929
ATOM 1929 CE2 PHE 257 78. .005 29, .885 30 .574 1 .00 52 .88 1SG1930
ATOM 1930 CZ PHE 257 78. .139 28, .762 29 .795 1 .00 52 .88 1SG1931
ATOM 1931 C PHE 257 78. .121 28, .697 34 .678 1 .00 52 .88 1SG1932
ATOM 1932 O PHE 257 77. .301 28, .417 33 .801 1, .00 52 .88 1SG1933
ATOM 1933 N HIS 258 77, .795 29, .352 35, .804 1, .00 45 .39 1SG1934
ATOM 1934 CA HIS 258 76. .458 29, .768 36, .074 1, .00 45, .39 1SG1935
ATOM 1935 NDl HIS 258 75. .679 26. .488 37. .854 1, .00 45, .39 1SG1936
ATOM 1936 CG HIS 258 75. .831 27. .455 36, .885 1, .00 45, .39 1SG1937
ATOM 1937 CB HIS 258 75. .776 28. .925 37. .160 1, .00 45, .39 1SG1938
ATOM 1938 NE2 HIS 258 76. .011 25. .418 35. .934 1, .00 45. .39 1SG1939
ATOM 1939 CD2 HIS 258 76. .032 26. .785 35. .718 1. .00 45. .39 1SG1940
ATOM 1940 CE1 HIS 258 75. .796 25. .289 37, .230 1. .00 45. .39 1SG1941
ATOM 1941 C HIS 258 76. .583 31. .126 36, .667 1. .00 45. .39 1SG1942
ATOM 1942 O HIS 258 77, .662 31, .524 37, .102 1. .00 45. .39 1SG1943
ATOM 1943 N VAL 259 75. .480 31. .888 36. .683 1. .00 38. .37 1SG1944
ATOM 1944 CA VAL 259 75. .565 33. .165 37. .316 1. .00 38. .37 1SG1945
ATOM 1945 CB VAL 259 75. .756 34. .313 36. .370 1. .00 38. .37 1SG1946
ATOM 1946 CGI VAL 259 75. .698 35. .621 37. .179 1. .00 38. .37 1SG1947
ATOM 1947 CG2 VAL 259 77. .082 34. ,111 35. .618 1. ,00 38. .37 1SG1948
ATOM 1948 C VAL 259 74. .280 33. ,389 38. .031 1. .00 38. ,37 1SG1949
ATOM 1949 O VAL 259 73. .223 32. ,934 37. ,596 1. ,00 38. ,37 1SG1950
ATOM 1950 N ASN 260 74. .349 34. ,096 39. ,172 1. ,00 37. ,72 1SG1951
ATOM 1951 CA ASN 260 73. .160 34. .386 39. .908 1. .00 37. .72 1SG1952
ATOM 1952 CB ASN 260 73. .271 34. .050 41. .406 1. .00 37. .72 1SG1953
ATOM 1953 CG ASN 260 71. .905 34. .247 42. .048 1. .00 37. ,72 1SG1954
ATOM 1954 ODl ASN 260 71. .261 35. ,279 41. .866 1. ,00 37. ,72 1SG1955
ATOM 1955 ND2 ASN 260 71. ,445 33. ,227 42. ,821 1. ,00 37. ,72 1SG1956
ATOM 1956 C ASN 260 72. ,960 35. ,857 39. ,790 1. .00 37. ,72 1SG1957 ATOM 1957 O ASN 260 73,.880 36..638 40..027 1..00 37,.72 1SG1958
ATOM 1958 N ILE 261 71 .744 36, .277 39. .400 1, .00 39, .84 1SG1959
ATOM 1959 CA ILE 261 71, .525 37, .681 39. .265 1. .00 39, .84 1SG1960
ATOM 1960 CB ILE 261 71 .113 38, .097 37. .884 1. .00 39, .84 1SG1961
ATOM 1961 CG2 ILE 261 72, .297 37. .780 36. .954 1. .00 39, .84 1SG1962
ATOM 1962 CGI ILE 261 69 .805 37, .425 37. .448 1. .00 39, .84 1SG1963
ATOM 1963 CDl ILE 261 69, .962 35, .927 37. .213 1. .00 39. .84 1SG1964
ATOM 1964 C ILE 261 70, .500 38, .104 40, .264 1. .00 39. .84 1SG1965
ATOM 1965 O ILE 261 69 .455 37 .474 40, .422 1, .00 39 .84 1SG1966
ATOM 1966 N GLN 262 70, .813 39, .194 40, .995 1. .00 42. .44 1SG1967
ATOM 1967 CA GLN 262 69 .938 39 .696 42, .013 1. .00 42. .44 1SG1968
ATOM 1968 CB GLN 262 70, .622 39, .875 43. .379 1. .00 42. .44 1SG1969
ATOM 1969 CG GLN 262 71 .730 40, .930 43. .376 1, .00 42. .44 1SG1970
ATOM 1970 CD GLN 262 72, .311 41, .005 44. .781 1. .00 42, .44 1SG1971
ATOM 1971 OEl GLN 262 71, .818 40, .360 45. .705 1. .00 42. .44 1SG1972
ATOM 1972 NE2 GLN 262 73 .391 41 .814 44, .948 1. .00 42 .44 1SG1973
ATOM 1973 C GLN 262 69, .455 41, .039 41, .578 1, .00 42 .44 1SG1974
ATOM 1974 O GLN 262 69 .955 41 .617 40, .615 1. .00 42 .44 1SG1975
ATOM 1975 N ASP 263 68, .444 41, .564 42, .294 1. .00 45 .40 1SG1976
ATOM 1976 CA ASP 263 67 .855 42 .829 41, .958 1, .00 45 .40 1SG1977
ATOM 1977 CB ASP 263 66, .646 43, .221 42, .812 1. .00 45 .40 1SG1978
ATOM 1978 CG ASP 263 67 .059 43 .312 44, .274 1. .00 45 .40 1SG1979
ATOM 1979 ODl ASP 263 67 .966 42 .540 44 .679 1, .00 45 .40 1SG1980
ATOM 1980 OD2 ASP 263 66 .473 44, .152 45, .008 1, .00 45 .40 1SG1981
ATOM 1981 C ASP 263 68 .847 43 .938 42 .108 1 .00 45 .40 1SG1982
ATOM 1982 O ASP 263 68, .755 44, .944 41, .408 1, .00 45 .40 1SG1983
ATOM 1983 N THR 264 69 .808 43 .801 43 .038 1, .00 43 .03 1SG1984
ATOM 1984 CA THR 264 70, .744 44. .854 43, .323 1, .00 43 .03 1SG1985
ATOM 1985 CB THR 264 71 .684 44 .517 44 .442 1, .00 43 .03 1SG1986
ATOM 1986 OGl THR 264 70 .955 44 .246 45 .630 1 .00 43 .03 1SG1987
ATOM 1987 CG2 THR 264 72, .628 45, .711 44, .661 1, .00 43 .03 1SG1988
ATOM 1988 C THR 264 71 .583 45 .165 42 .121 1, .00 43 .03 1SG1989
ATOM 1989 O THR 264 71, .954 46, .317 41, .903 1, .00 43 .03 1SG1990
ATOM 1990 N MET 265 71 .911 44 .146 41 .308 1, .00 41 .07 1SG1991
ATOM 1991 CA MET 265 72. .795 44, .326 40, .192 1, .00 41 .07 1SG1992
ATOM 1992 CB MET 265 73 .041 43 .012 39 .435 1, .00 41 .07 1SG1993
ATOM 1993 CG MET 265 73 .717 41 .953 40 .307 1 .00 41 .07 1SG1994
ATOM 1994 SD MET 265 74. .030 40, .364 39, .483 1, .00 41 .07 1SG1995
ATOM 1995 CE MET 265 74 .612 39 .533 40, .989 1, .00 41 .07 1SG1996
ATOM 1996 C MET 265 72. .214 45, .319 39, .231 1, .00 41. .07 1SG1997
ATOM 1997 O MET 265 72 .941 46 .112 38, .635 1, .00 41 .07 1SG1998
ATOM 1998 N ILE 266 70, .885 45, .295 39, .042 1. .00 43. .53 1SG1999
ATOM 1999 CA ILE 266 70, .244 46, .180 38. .111 1. .00 43, .53 1SG2000
ATOM 2000 CB ILE 266 68 .822 45 .793 37, .810 1. .00 43, .53 1SG2001
ATOM 2001 CG2 ILE 266 68, .240 46, .851 36, .857 1. .00 43. .53 1SG2002
ATOM 2002 CGI ILE 266 68, .746 44 .362 37, .253 1. .00 43, .53 1SG2003
ATOM 2003 CDl ILE 266 69, .042 43. .284 38. .296 1. .00 43, .53 1SG2004
ATOM 2004 C ILE 266 70, .191 47, .559 38, .695 1. .00 43, .53 1SG2005
ATOM 2005 O ILE 266 69 .933 47 .738 39, .884 1, .00 43, .53 1SG2006
ATOM 2006 N GLY 267 70, .452 48, .582 37, .856 1. .00 47, .81 1SG2007
ATOM 2007 CA GLY 267 70, .351 49 .939 38. .311 1. .00 47, .81 1SG2008
ATOM 2008 C GLY 267 68. .893 50, .246 38. .239 1. .00 47. .81 1SG2009
ATOM 2009 O GLY 267 68. .088 49, .338 38. .042 1. .00 47. .81 1SG2010
ATOM 2010 N GLU 268 68. .494 51. .523 38. .399 1. .00 55. .66 1SG2011
ATOM 2011 CA GLU 268 67. .082 51, .774 38. .333 1. .00 55. .66 1SG2012
ATOM 2012 CB GLU 268 66. .687 53, .242 38. .582 1. .00 55, .66 1SG2013
ATOM 2013 CG GLU 268 67. .266 54. .234 37. .570 1. ,00 55. .66 1SG2014 ATOM 2014 CD GLU 268 66..721 55..615 37,.906 1..00 55..66 1SG2015
ATOM 2015 OEl GLU 268 66. .198 55. .785 39. .039 1. .00 55. ,66 1SG2016
ATOM 2016 OE2 GLU 268 66. .818 56. .518 37. .032 1. .00 55. ,66 1SG2017
ATOM 2017 C GLU 268 66. .622 51. .384 36. .962 1. .00 55. .66 1SG2018
ATOM 2018 O GLU 268 66. .943 52. .033 35, .968 1. .00 55. .66 1SG2019
ATOM 2019 N LEU 269 65. .864 50, .272 36, .892 1. .00 61. .41 1SG2020
ATOM 2020 CA LEU 269 65. .345 49, .725 35. .670 1. .00 61. .41 1SG2021
ATOM 2021 CB LEU 269 66. .332 48, .797 34. .923 1. .00 61. .41 1SG2022
ATOM 2022 CG LEU 269 67, .565 49, .467 34, .281 1. .00 61. .41 1SG2023
ATOM 2023 CD2 LEU 269 68, .188 48, .551 33, .216 1. .00 61. .41 1SG2024
ATOM 2024 CDl LEU 269 68, .590 49, .933 35, .324 1, .00 61. .41 1SG2025
ATOM 2025 C LEU 269 64, .192 48. .859 36, .076 1. .00 61. .41 1SG2026
ATOM 2026 O LEU 269 63, .691 48, .999 37, .190 1. .00 61. .41 1SG2027
ATOM 2027 N PRO 270 63, .720 47, .988 35, .213 1. .00 62. .29 1SG2028
ATOM 2028 CA PRO 270 62, .703 47, .078 35 .652 1, .00 62. .29 1SG2029
ATOM 2029 CD PRO 270 63 .575 48 .300 33 .798 1. .00 62. .29 1SG2030
ATOM 2030 CB PRO 270 62, .209 46, .366 34, .398 1. .00 62. .29 1SG2031
ATOM 2031 CG PRO 270 62, .398 47, .437 33, .304 1. .00 62. .29 1SG2032
ATOM 2032 C PRO 270 63, .280 46, .224 36 .733 1. .00 62, .29 1SG2033
ATOM 2033 O PRO 270 64 .415 45, .773 36 .601 1. .00 62, .29 1SG2034
ATOM 2034 N PRO 271 62 .563 46 .050 37 .804 1. .00 58, .07 1SG2035
ATOM 2035 CA PRO 271 63, .125 45, .263 38, .867 1. .00 58, .07 1SG2036
ATOM 2036 CD PRO 271 61, .834 47, .197 38 .326 1. .00 58, .07 1SG2037
ATOM 2037 CB PRO 271 62 .548 45, .809 40 .171 1, .00 58, .07 1SG2038
ATOM 2038 CG PRO 271 62 .162 47 .255 39 .826 1. .00 58 .07 1SG2039
ATOM 2039 C PRO 271 62 .877 43 .806 38 .722 1. .00 58 .07 1SG2040
ATOM 2040 O PRO 271 61. .937 43, .415 38, .031 1, .00 58, .07 1SG2041
ATOM 2041 N GLN 272 63 .705 42 .985 39 .390 1. .00 50, .88 1SG2042
ATOM 2042 CA GLN 272 63 .451 41 .584 39 .396 1. .00 50 .88 1SG2043
ATOM 2043 CB GLN 272 64 .741 40 .746 39 .416 1. .00 50 .88 1SG2044
ATOM 2044 CG GLN 272 65 .611 40 .929 38 .170 1. .00 50 .88 1SG2045
ATOM 2045 CD GLN 272 66. .850 40, .058 38, .331 1. .00 50, .88 1SG2046
ATOM 2046 OEl GLN 272 67. .233 39 .320 37 .424 1, .00 50, .88 1SG2047
ATOM 2047 NE2 GLN 272 67 .502 40 .151 39 .521 1. .00 50, .88 1SG2048
ATOM 2048 C GLN 272 62 .771 41 .363 40 .691 1. .00 50, .88 1SG2049
ATOM 2049 O GLN 272 63 .387 40 .853 41 .615 1. .00 50 .88 1SG2050
ATOM 2050 N THR 273 61, .487 41. .754 40, .795 1. .00 42. .85 1SG2051
ATOM 2051 CA THR 273 60 .770 41, .606 42 .027 1. .00 42, .85 1SG2052
ATOM 2052 CB THR 273 60 .588 42 .903 42 .757 1. .00 42. .85 1SG2053
ATOM 2053 OGl THR 273 59 .810 43 .800 41 .978 1. .00 42. .85 1SG2054
ATOM 2054 CG2 THR 273 61 .977 43 .510 43 .020 1, .00 42. .85 1SG2055
ATOM 2055 C THR 273 59, .414 41, .096 41, .672 1. .00 42. .85 1SG2056
ATOM 2056 O THR 273 58, .982 41, .210 40, .528 1. .00 42. .85 1SG2057
ATOM 2057 N THR 274 58, .709 40, .503 42, .653 1. .00 37. .92 1SG2058
ATOM 2058 CA THR 274 57, .402 39, .977 42, .395 1. .00 37. .92 1SG2059
ATOM 2059 CB THR 274 56 .809 39 .252 43, .566 1. .00 37. .92 1SG2060
ATOM 2060 OGl THR 274 56. .725 40, .113 44, .692 1. .00 37. .92 1SG2061
ATOM 2061 CG2 THR 274 57. .686 38, .030 43, .877 1. .00 37. .92 1SG2062
ATOM 2062 C THR 274 56. .497 41, .110 42, .048 1. .00 37. .92 1SG2063
ATOM 2063 0 THR 274 55. .617 40, .971 41, .200 1. .00 37. .92 1SG2064
ATOM 2064 N LYS 275 56 .683 42, .270 42, .704 1. .00 35. .76 1SG2065
ATOM 2065 CA LYS 275 55. .810 43. .379 42. .456 1. .00 35. ,76 1SG2066
ATOM 2066 CB LYS 275 56. .163 44. .624 43. .288 1. .00 35. .76 1SG2067
ATOM 2067 CG LYS 275 55. .878 44. .479 44. .783 1. .00 35. .76 1SG2068
ATOM 2068 CD LYS 275 56. .500 45. .594 45. .627 1. .00 35. .76 1SG2069
ATOM 2069 CE LYS 275 56. .132 45. .524 47. .110 1. .00 35. .76 1SG2070
ATOM 2070 NZ LYS 275 54. .698 45. .843 47. .290 1. ,00 35. .76 1SG2071 ATOM 2071 C LYS 275 55..910 43..783 41,.017 1..00 35..76 1SG2072
ATOM 2072 O LYS 275 54. .894 43. .960 40, .349 1. .00 35. .76 1SG2073
ATOM 2073 N THR 276 57, .141 43. .929 40, .493 1. .00 35. .57 1SG2074
ATOM 2074 CA THR 276 57, .304 44. .356 39, .132 1. .00 35. .57 1SG2075
ATOM 2075 CB THR 276 58, .744 44. .537 38, .753 1. .00 35. .57 1SG2076
ATOM 2076 OGl THR 276 59, .357 45. .499 39, .599 1. .00 35. .57 1SG2077
ATOM 2077 CG2 THR 276 58, .812 45. .000 37, .287 1. .00 35. .57 1SG2078
ATOM 2078 C THR 276 56, .737 43, .306 38 .234 1. .00 35. .57 1SG2079
ATOM 2079 O THR 276 56 .037 43, .597 37 .265 1. .00 35, .57 1SG2080
ATOM 2080 N LEU 277 57 .016 42. .040 38 .576 1. .00 39. .48 1SG2081
ATOM 2081 CA LEU 277 56 .615 40. .884 37 .834 1. .00 39, .48 1SG2082
ATOM 2082 CB LEU 277 57, .208 39. .601 38. .443 1. .00 39. .48 1SG2083
ATOM 2083 CG LEU 277 56. .950 38. .319 37. .637 1. .00 39. .48 1SG2084
ATOM 2084 CD2 LEU 277 57. .636 37. .125 38. .314 1. .00 39, .48 1SG2085
ATOM 2085 CDl LEU 277 57. .425 38. .468 36 , .186 1. .00 39, .48 1SG2086
ATOM 2086 C LEU 277 55, .120 40. .839 37, .857 1. .00 39, .48 1SG2087
ATOM 2087 O LEU 277 54, .486 40. .230 36, .997 1. .00 39, .48 1SG2088
ATOM 2088 N ALA 278 54. .525 41. .486 38, .871 1. .00 43, .11 1SG2089
ATOM 2089 CA ALA 278 53. .104 41. .540 39, .066 1. .00 43, .11 1SG2090
ATOM 2090 CB ALA 278 52. .686 42. .338 40, .313 1. .00 43, .11 1SG2091
ATOM 2091 C ALA 278 52. .476 42. .195 37, .876 1, .00 43, .11 1SG2092
ATOM 2092 O ALA 278 51. .317 41. .941 37, .558 1. .00 43, .11 1SG2093
ATOM 2093 N ARG 279 53. .211 43. .088 37, .196 1. .00 51, .88 1SG2094
ATOM 2094 CA ARG 279 52, .636 43. .775 36, .079 1. .00 51 .88 1SG2095
ATOM 2095 CB ARG 279 53. .645 44. .674 35 .344 1. .00 51, .88 1SG2096
ATOM 2096 CG ARG 279 54, .141 45. .869 36 .160 1, .00 51 .88 1SG2097
ATOM 2097 CD ARG 279 55, .141 46, .740 35 .397 1. .00 51 .88 1SG2098
ATOM 2098 NE ARG 279 55 .524 47, .878 36 .279 1. .00 51 .88 1SG2099
ATOM 2099 CZ ARG 279 56 .248 48. .916 35 .768 1, .00 51 .88 1SG2100
ATOM 2100 NHl ARG 279 56 .620 48, .906 34, .455 1. .00 51 .88 1SG2101
ATOM 2101 NH2 ARG 279 56, .598 49, .965 36 .568 1. .00 51 .88 1SG2102
ATOM 2102 C ARG 279 52 .158 42, .765 35 .080 1, .00 51 .88 1SG2103
ATOM 2103 O ARG 279 51 .090 42, .939 34 .494 1. .00 51 .88 1SG2104
ATOM 2104 N PHE 280 52 .923 41, .680 34 .842 1. .00 65 .14 1SG2105
ATOM 2105 CA PHE 280 52, .460 40. .779 33 .828 1, .00 65 .14 1SG2106
ATOM 2106 CB PHE 280 53 .380 40. .776 32 .590 1, .00 65 .14 1SG2107
ATOM 2107 CG PHE 280 54, .795 40. .536 32 .999 1. .00 65 .14 1SG2108
ATOM 2108 CDl PHE 280 55 .600 41. .599 33 .343 1. .00 65 .14 1SG2109
ATOM 2109 CD2 PHE 280 55 .326 39. .268 33 .038 1, .00 65 .14 1SG2110
ATOM 2110 CE1 PHE 280 56 .908 41. .400 33 .717 1, .00 65 .14 1SG2111
ATOM 2111 CE2 PHE 280 56, .633 39. .061 33, .409 1, .00 65, .14 1SG2112
ATOM 2112 CZ PHE 280 57 .427 40. .129 33, .750 1. .00 65, .14 1SG2113
ATOM 2113 C PHE 280 52 .240 39. .368 34, .311 1. .00 65, .14 1SG2114
ATOM 2114 O PHE 280 51, .519 38. .625 33, .645 1, .00 65, .14 1SG2115
ATOM 2115 N ILE 281 52 .829 38. .920 35, .446 1. .00 75, .38 1SG2116
ATOM 2116 CA ILE 281 52 .540 37. .548 35, .787 1. .00 75, .38 1SG2117
ATOM 2117 CB ILE 281 53, .751 36. .663 35, .615 1. .00 75, .38 1SG2118
ATOM 2118 CG2 ILE 281 53, .389 35. .214 35, .976 1. .00 75, .38 1SG2119
ATOM 2119 CGI ILE 281 54 .262 36. .767 34. .171 1. .00 75, .38 1SG2120
ATOM 2120 CDl ILE 281 53, .234 36. .330 33. .127 1. .00 75, .38 1SG2121
ATOM 2121 C ILE 281 52, .063 37. .418 37. .213 1. .00 75, .38 1SG2122
ATOM 2122 O ILE 281 52, .804 36. .895 38, .046 1. .00 75, .38 1SG2123
ATOM 2123 N PRO 282 50, .900 37. .888 37, .589 1, .00 82, .42 1SG2124
ATOM 2124 CA PRO 282 50, .510 37. .589 38, .947 1. .00 82, .42 1SG2125
ATOM 2125 CD PRO 282 50, .555 39. .251 37, .231 1, .00 82, .42 1SG2126
ATOM 2126 CB PRO 282 50, .160 38. .926 39, .592 1. .00 82, .42 1SG2127
ATOM 2127 CG PRO 282 49. .706 39. ,780 38. .399 1. .00 82. .42 1SG2128 ATOM 2128 C PRO 282 49,.364 36..625 39..068 1..00 82..42 1SG2129
ATOM 2129 O PRO 282 48, .258 37. .037 38. .715 1. .00 82. .42 1SG2130
ATOM 2130 N GLU 283 49, .516 35, .374 39. .559 1. .00 80. .58 1SG2131
ATOM 2131 CA GLU 283 50, .732 34, .644 39. .758 1. .00 80. .58 1SG2132
ATOM 2132 CB GLU 283 51, .416 34. .376 38. .408 1. .00 80. .58 1SG2133
ATOM 2133 CG GLU 283 50 .492 33. .523 37, .521 1. .00 80. .58 1SG2134
ATOM 2134 CD GLU 283 50, .854 33. .722 36, .057 1. .00 80. .58 1SG2135
ATOM 2135 OEl GLU 283 50 .621 34. .851 35, .548 1. .00 80. .58 1SG2136
ATOM 2136 OE2 GLU 283 51, .368 32, .759 35, .429 1. .00 80, .58 1SG2137
ATOM 2137 C GLU 283 51, .675 35. .176 40. .798 1. .00 80, .58 1SG2138
ATOM 2138 O GLU 283 51 .354 35, .233 41, .982 1. .00 80, .58 1SG2139
ATOM 2139 N VAL 284 52, .895 35, .556 40, .370 1. .00 68, .66 1SG2140
ATOM 2140 CA VAL 284 53 .974 35 .887 41, .259 1, .00 68 .66 1SG2141
ATOM 2141 CB VAL 284 55, .141 36, .458 40, .518 1. .00 68, .66 1SG2142
ATOM 2142 CGI VAL 284 55, .633 35. .367 39. .552 1, .00 68, .66 1SG2143
ATOM 2143 CG2 VAL 284 54 .709 37. .762 39, .823 1. .00 68, .66 1SG2144
ATOM 2144 C VAL 284 53, .533 36, .863 42, .299 1. .00 68, .66 1SG2145
ATOM 2145 O VAL 284 53 .857 36 .695 43 .474 1. .00 68 .66 1SG2146
ATOM 2146 N ALA 285 52 .797 37, .914 41, .914 1. .00 58 .26 1SG2147
ATOM 2147 CA ALA 285 52, .334 38, .830 42, .915 1. .00 58, .26 1SG2148
ATOM 2148 CB ALA 285 51 .620 40 .054 42 .317 1. .00 58 .26 1SG2149
ATOM 2149 C ALA 285 51, .355 38, .136 43, .819 1, .00 58 .26 1SG2150
ATOM 2150 O ALA 285 51 .395 38 .324 45 .034 1. .00 58 .26 1SG2151
ATOM 2151 N VAL 286 50 .424 37, .333 43, .256 1. .00 53 .35 1SG2152
ATOM 2152 CA VAL 286 49, .422 36, .730 44, .094 1. .00 53 .35 1SG2153
ATOM 2153 CB VAL 286 48 .269 36 .106 43 .342 1, .00 53 .35 1SG2154
ATOM 2154 CGI VAL 286 48, .720 34, .843 42, .593 1, .00 53 .35 1SG2155
ATOM - 2155 CG2 VAL 286 47 .142 35 .839 44 .353 1 .00 53 .35 1SG2156
ATOM 2156 C VAL 286 50 .003 35, .704 45, .024 1, .00 53 .35 1SG2157
ATOM 2157 O VAL 286 49, .733 35, .735 46, .224 1, .00 53 .35 1SG2158
ATOM 2158 N ALA 287 50 .802 34, .752 44 .500 1 .00 53 .87 1SG2159
ATOM 2159 CA ALA 287 51, .349 33, .716 45, .330 1, .00 53 .87 1SG2160
ATOM 2160 CB ALA 287 52 .085 32 .634 44 .520 1, .00 53 .87 1SG2161
ATOM 2161 C ALA 287 52, .334 34, .294 46, .295 1, .00 53 .87 1SG2162
ATOM 2162 O ALA 287 52, .291 33, .997 47, .489 1, .00 53, .87 1SG2163
ATOM 2163 N TYR 288 53 .251 35, .148 45, .798 1, .00 62 .04 1SG2164
ATOM 2164 CA TYR 288 54, .248 35, .716 46, .657 1, .00 62 .04 1SG2165
ATOM 2165 CB TYR 288 55 .650 35 .589 46 .044 1, .00 62 .04 1SG2166
ATOM 2166 CG TYR 288 55, .742 34, .175 45, .578 1, .00 62 .04 1SG2167
ATOM 2167 CDl TYR 288 55, .305 33, .855 44 , .313 1. .00 62, .04 1SG2168
ATOM 2168 CD2 TYR 288 56, .233 33, .173 46, .382 1. .00 62 .04 1SG2169
ATOM 2169 CE1 TYR 288 55, .364 32, .563 43, .846 1, .00 62, .04 1SG2170
ATOM 2170 CE2 TYR 288 56, .294 31, .878 45, .918 1, .00 62 .04 1SG2171
ATOM 2171 CZ TYR 288 55, .862 31, .570 44, .652 1. .00 62, .04 1SG2172
ATOM 2172 OH TYR 288 55, .926 30. .241 44. .182 1. .00 62. .04 1SG2173
ATOM 2173 C TYR 288 53, .916 37, .174 46. .725 1. .00 62, .04 1SG2174
ATOM 2174 O TYR 288 54, .451 37. .990 45. .976 1. .00 62. .04 1SG2175
ATOM 2175 N PRO 289 53, .092 37, .498 47, .681 1. .00 70, .76 1SG2176
ATOM 2176 CA PRO 289 52, .488 38, .801 47, .807 1. .00 70, .76 1SG2177
ATOM 2177 CD PRO 289 53. .064 36, .758 48, .931 1. ,00 70. .76 1SG2178
ATOM 2178 CB PRO 289 51, .727 38. .768 49, .131 1. .00 70. . 16 1SG2179
ATOM 2179 CG PRO 289 52. .521 37. .752 49. .971 1. ,00 70. .76 1SG2180
ATOM 2180 C PRO 289 53, .434 39, .950 47. .748 1. ,00 70. .76 1SG2181
ATOM 2181 O PRO 289 53. .111 40. .956 47. .126 1. ,00 70. .76 1SG2182
ATOM 2182 N LYS 290 54. .583 39. ,875 48. .417 1. ,00 74. .36 1SG2183
ATOM 2183 CA LYS 290 55. .507 40. .956 48. .303 1. .00 74. .36 1SG2184
ATOM 2184 CB LYS 290 55. .247 42. ,097 49. .304 1. .00 74. .36 1SG2185 ATOM 2185 CG LYS 290 56.,123 43..334 49..087 1..00 74..36 1SG2186
ATOM 2186 CD LYS 290 57. .623 43. .081 49. .256 1. .00 74. .36 1SG2187
ATOM 2187 CE LYS 290 58. .484 44. .326 49. .035 1. ,00 74. .36 1SG2188
ATOM 2188 NZ LYS 290 59. ,914 43. .991 49. .217 1. ,00 74. .36 1SG2189
ATOM 2189 C LYS 290 56. ,779 40. .317 48. .675 1. .00 74. .36 1SG2190
ATOM 2190 0 LYS 290 57. .045 40. .092 49, .854 1. .00 74. .36 1SG2191
ATOM 2191 N SER 291 57. ,610 39. .988 47. .681 1. .00 75. .44 1SG2192
ATOM 2192 CA SER 291 58. ,763 39. .286 48. .114 1. ,00 75. .44 1SG2193
ATOM 2193 CB SER 291 58. , 782 37. .796 47. .735 1. .00 75. .44 1SG2194
ATOM 2194 OG SER 291 58. .933 37. .646 46. .332 1. .00 75. .44 1SG2195
ATOM 2195 C SER 291 59. .954 39. .911 47. .519 1. .00 75. .44 1SG2196
ATOM 2196 O SER 291 59. .870 40, .646 46. .531 1, .00 75. .44 1SG2197
ATOM 2197 N LYS 292 61. .095 39, .591 48, .154 1. .00 71. .36 1SG2198
ATOM 2198 CA LYS 292 62. .362 40 .081 47 .756 1. .00 71 .36 1SG2199
ATOM 2199 CB LYS 292 63, .556 39 .404 48 .457 1. .00 71, .36 1SG2200
ATOM 2200 CG LYS 292 64, .912 39 .956 48, .005 1. .00 71, .36 1SG2201
ATOM 2201 CD LYS 292 66, .096 39 .562 48, .883 1. .00 71, .36 1SG2202
ATOM 2202 CE LYS 292 67. .419 40 .174 48 .417 1, .00 71 .36 1SG2203
ATOM 2203 NZ LYS 292 67. .749 39 .693 47 .057 1, .00 71 .36 1SG2204
ATOM 2204 C LYS 292 62. .453 39 .779 46 .335 1, .00 71, .36 1SG2205
ATOM 2205 O LYS 292 61. .831 38 .863 45, .794 1, .00 71, .36 1SG2206
ATOM 2206 N PRO 293 63, .232 40 .626 45 .766 1 .00 60 .86 1SG2207
ATOM 2207 CA PRO 293 63 .433 40 .572 44 .373 1, .00 60 .86 1SG2208
ATOM 2208 CD PRO 293 63. .431 41 .962 46 .304 1, .00 60 .86 1SG2209
ATOM 2209 CB PRO 293 64, .394 41, .709 44, .094 1, .00 60 . .86 1SG2210
ATOM 2210 CG PRO 293 64, .009 42, .773 45 .139 1 .00 60 .86 1SG2211
ATOM 2211 C PRO 293 63 .852 39 .203 44 .001 1 .00 60 .86 1SG2212
ATOM 2212 O PRO 293 64, .759 38 .643 44 .614 1, .00 60 .86 1SG2213
ATOM 2213 N LEU 294 63, .162 38 .656 42 .993 1, . 00 50 .26 1SG2214
ATOM 2214 CA LEU 294 63, .368 37, .317 42, .576 1, .00 50 .26 1SG2215
ATOM 2215 CB LEU 294 62 .582 36 .945 41 .308 1 .00 50 .26 1SG2216
ATOM 2216 CG LEU 294 61 .054 36 .990 41 .480 1 .00 50 .26 1SG2217
ATOM 2217 CD2 LEU 294 60, .348 36 .476 40 .217 1, .00 50 .26 1SG2218
ATOM 2218 CDl LEU 294 60. .575 38, .393 41, .881 1, .00 50 .26 1SG2219
ATOM 2219 C LEU 294 6 .804 37 .171 42 .250 1 .00 50 .26 1SG2220
ATOM 2220 O LEU 294 65 .467 38 .112 41 .816 1, .00 50 .26 1SG2221
ATOM 2221 N THR 295 65. .319 35 .959 4 .507 1, .00 39, .55 1SG2222
ATOM 2222 CA THR 295 66 . .677 35, .651 42, .211 1. .00 39, .55 1SG2223
ATOM 2223 CB THR 295 67. .361 34 .890 43 .309 1 .00 39 .55 1SG2224
ATOM 2224 OGl THR 295 67, .345 35 .646 44 .511 1, .00 39, .55 1SG2225
ATOM 2225 CG2 THR 295 68, .807 34, .590 42, .885 1, .00 39, .55 1SG2226
ATOM 2226 C THR 295 66, .611 34, .755 41, .026 1. .00 39. .55 1SG2227
ATOM 2227 O THR 295 65. .789 33 .841 40 .976 1. .00 39, .55 1SG2228
ATOM 2228 N THR 296 67 .463 35 .010 40 .020 1, .00 32, .05 1SG2229
ATOM 2229 CA THR 296 67, .403 34, .180 38, .859 1, .00 32. .05 1SG2230
ATOM 2230 CB THR 296 67, .212 34, .933 37, .582 1. .00 32. .05 1SG2231
ATOM 2231 OGl THR 296 66, .004 35, .678 37, .620 1. .00 32. .05 1SG2232
ATOM 2232 CG2 THR 296 67, .171 33 .910 36 .440 1, .00 32. .05 1SG2233
ATOM 2233 C THR 296 68, .693 33, .441 38 .754 1. .00 32. .05 1SG2234
ATOM 2234 O THR 296 69. .754 33, .956 39, .103 1. .00 32. .05 1SG2235
ATOM 2235 N GLN 297 68. .623 32, .182 38, .286 1. .00 30, .61 1SG2236
ATOM 2236 CA GLN 297 69, .825 31, .424 38 .140 1. .00 30. .61 1SG2237
ATOM 2237 CB GLN 297 69, .794 30, .066 38, .868 1. .00 30. .61 1SG2238
ATOM 2238 CG GLN 297 69, .704 30, .201 40, .391 1. .00 30. .61 1SG2239
ATOM 2239 CD GLN 297 69. .679 28. .808 41. .006 1. ,00 30. .61 1SG2240
ATOM 2240 OEl GLN 297 69. .778 27, .800 40. .308 1. .00 30. .61 1SG2241
ATOM 2241 NE2 GLN 297 69 .542 28 .749 42 .358 1. .00 30. .61 1SG2242 ATOM 2242 C GLN 297 70..001 31..160 36..683 1..00 30..61 1SG2243
ATOM 2243 O GLN 297 69. .093 30. .678 36. .007 1. .00 30. .61 1SG2244
ATOM 2244 N ILE 298 71. .195 31. .493 36. .160 1. .00 33. .15 1SG2245
ATOM 2245 CA ILE 298 71. .470 31. .279 34. .773 1. .00 33. .15 1SG2246
ATOM 2246 CB ILE 298 71. .933 32, .528 34, .081 1. .00 33. .15 1SG2247
ATOM 2247 CG2 ILE 298 70, .770 33, .534 34, .096 1. .00 33. .15 1SG2248
ATOM 2248 CGI ILE 298 73. .220 33. .058 34, .732 1. .00 33. .15 1SG2249
ATOM 2249 CDl ILE 298 73. .858 34. .213 33, .967 1. .00 33. .15 1SG2250
ATOM 2250 C ILE 298 72. .542 30. .243 34, .699 1. .00 33. .15 1SG2251
ATOM 2251 O ILE 298 73, .624 30. .398 35, .262 1. .00 33. .15 1SG2252
ATOM 2252 N LYS 299 72, .237 29. .132 34, .005 1. .00 36. .79 1SG2253
ATOM 2253 CA LYS 299 73, .153 28. .039 33, .881 1. .00 36. .79 1SG2254
ATOM 2254 CB LYS 299 72. .663 26. .765 34, .590 1. .00 36. .79 1SG2255
ATOM 2255 CG LYS 299 73, .609 25, .571 34 .451 1. .00 36, .79 1SG2256
ATOM 2256 CD LYS 299 73, .214 24. .372 35, .317 1. .00 36, .79 1SG2257
ATOM 2257 CE LYS 299 74, .077 23, .131 35, .077 1. .00 36, .79 1SG2258
ATOM 2258 NZ LYS 299 73, .610 22, .017 35, .933 1, .00 36. .79 1SG2259
ATOM 2259 C LYS 299 73, .243 27, .696 32, .436 1. .00 36. .79 1SG2260
ATOM 2260 O LYS 299 72, .397 28 .088 31 .634 1. .00 36. .79 1SG2261
ATOM 2261 N ILE 300 74, .294 26, .939 32 .073 1. .00 40. .50 1SG2262
ATOM 2262 CA ILE 300 74, .442 26 .514 30 .717 1. .00 40, .50 1SG2263
ATOM 2263 CB ILE 300 75, .859 26. .592 30, .232 1, .00 40. .50 1SG2264
ATOM 2264 CG2 ILE 300 76, .746 25 .791 31 .195 1 .00 40. .50 1SG2265
ATOM 2265 CGI ILE 300 75, .943 26 .175 28 .756 1. .00 40, .50 1SG2266
ATOM 2266 CDl ILE 300 77, .280 26 .509 28 .100 1. .00 40, .50 1SG2267
ATOM 2267 C ILE 300 73, .976 25. .096 30 .686 1. .00 40, .50 1SG2268
ATOM 2268 O ILE 300 74 , .491 24. .239 31, .402 1. .00 40, .50 1SG2269
ATOM 2269 N LYS 301 72 .927 24 .835 29 .882 1, .00 43, .00 1SG2270
ATOM 2270 CA LYS 301 72, .335 23 .531 29 .807 1, .00 43. .00 1SG2271
ATOM 2271 CB LYS 301 71, .068 23 .521 28 .929 1, .00 43, .00 1SG2272
ATOM 2272 CG LYS 301 70. .236 22. .236 29, .010 1, .00 43. .00 1SG2273
ATOM 2273 CD LYS 301 70 .940 20 .986 28 .478 1 .00 43 .00 1SG2274
ATOM 2274 CE LYS 301 70 .117 19 .705 28 .626 1, .00 43, .00 1SG2275
ATOM 2275 NZ LYS 301 70. .876 18 .554 28 .087 1, .00 43, .00 1SG2276
ATOM 2276 C LYS 301 73 , .312 22. .553 29 .232 1, .00 43. .00 1SG2277
ATOM 2277 O LYS 301 73, .527 21, .483 29, .800 1. .00 43. .00 1SG2278
ATOM 2278 N LYS 302 73 .943 22 .893 28 .090 1 .00 42. .63 1SG2279
ATOM 2279 CA LYS 302 74, .855 21 .964 27 .482 1, .00 42. .63 1SG2280
ATOM 2280 CB LYS 302 74, .296 21 .249 26 .238 1, .00 42, .63 1SG2281
ATOM 2281 CG LYS 302 73, .175 20, .255 26 .551 1. .00 42. .63 1SG2282
ATOM 2282 CD LYS 302 72 , .449 19 .740 25 .306 1, .00 42, .63 1SG2283
ATOM 2283 CE LYS 302 73, .104 18 .509 24 .673 1, .00 42, .63 1SG2284
ATOM 2284 NZ LYS 302 72, .597 17 .276 25 .316 1, .00 42. .63 1SG2285
ATOM 2285 C LYS 302 76, .072 22, .715 27 .054 1. .00 42. .63 1SG2286
ATOM 2286 O LYS 302 76. .151 23, .934 27 .188 1. .00 42. .63 1SG2287
ATOM 2287 N PRO 303 77. .041 21 .993 26 .555 1, .00 42. .52 1SG2288
ATOM 2288 CA PRO 303 78, .258 22 .620 26 .127 1, .00 42. .52 1SG2289
ATOM 2289 CD PRO 303 77, .254 20, .620 26 .983 1, .00 42. .52 1SG2290
ATOM 2290 CB PRO 303 79. .247 21 .484 25 .880 1. .00 42. .52 1SG2291
ATOM 2291 CG PRO 303 78. .767 20, .378 26 .839 1, .00 42. .52 1SG2292
ATOM 2292 C PRO 303 77. .999 23 .487 24 .942 1, .00 42. .52 1SG2293
ATOM 2293 O PRO 303 77, .306 23 .053 24 .024 1, .00 42. .52 1SG2294
ATOM 2294 N PRO 304 78. .548 24, .664 24 .925 1, .00 40. .55 1SG2295
ATOM 2295 CA PRO 304 78. .343 25, .587 23, .850 1. .00 40. ,55 1SG2296
ATOM 2296 CD PRO 304 79. .175 25 .271 26 .085 1. .00 40. .55 1SG2297
ATOM 2297 CB PRO 304 78. .881 26, .931 24 .347 1. .00 40. .55 1SG2298
ATOM 2298 CG PRO 304 79. .793 26, .566 25 .535 1. .00 40. .55 1SG2299 ATOM 2299 C PRO 304 79..038 25..070 22..632 1..00 40..55 1SG2300
ATOM 2300 O PRO 304 80. .071 24. .415 22. .755 1. .00 40. .55 1SG2301
ATOM 2301 N LYS 305 78. .487 25. .342 21, .438 1. .00 37. .73 1SG2302
ATOM 2302 CA LYS 305 79. .121 24. .871 20. .245 1. ,00 37. .73 1SG2303
ATOM 2303 CB LYS 305 78. ,168 24. ,130 19. .292 1. ,00 37. ,73 1SG2304
ATOM 2304 CG LYS 305 77. .663 22, .792 19. .829 1. .00 37. .73 1SG2305
ATOM 2305 CD LYS 305 76. .468 22. .240 19, .050 1. .00 37. .73 1SG2306
ATOM 2306 CE LYS 305 76. ,050 20. .835 19. .487 1. ,00 37. .73 1SG2307
ATOM 2307 NZ LYS 305 75. .649 20. .846 20, .912 1. .00 37. .73 1SG2308
ATOM 2308 C LYS 305 79. .603 26. .069 19, .502 1. .00 37. .73 1SG2309
ATOM 2309 O LYS 305 79. .003 27. .139 19, .581 1. .00 37. .73 1SG2310
ATOM 2310 N VAL 306 80, .729 25, .923 18, .778 1. .00 36. .76 1SG2311
ATOM 2311 CA VAL 306 81. .209 27. .007 17, .976 1. .00 36. .76 1SG2312
ATOM 2312 CB VAL 306 82. .505 27. .599 18, .457 1. .00 36, .76 1SG2313
ATOM 2313 CGI VAL 306 82. .278 28. .194 19 .857 1. .00 36. .76 1SG2314
ATOM 2314 CG2 VAL 306 83, .602 26. .525 18, .407 1. .00 36, .76 1SG2315
ATOM 2315 C VAL 306 81. .434 26. .445 16, .612 1. .00 36. .76 1SG2316
ATOM 2316 O VAL 306 82. .042 25. .387 16, .457 1. .00 36 .76 1SG2317
ATOM 2317 N THR 307 80. .935 27, .138 15 .573 1. .00 35 .12 1SG2318
ATOM 2318 CA THR 307 81. .115 26, .617 14, .253 1. .00 35, .12 1SG2319
ATOM 2319 CB THR 307 79. .825 26, .408 13 .514 1, .00 35 .12 1SG2320
ATOM 2320 OGl THR 307 78, .989 25, .517 14, .238 1. .00 35 .12 1SG2321
ATOM 2321 CG2 THR 307 80, .144 25, .819 12, .130 1. .00 35, .12 1SG2322
ATOM 2322 C THR 307 81, .929 27, .607 13 .489 1. .00 35 .12 1SG2323
ATOM 2323 O THR 307 81, .673 28, .810 13, .545 1. .00 35 .12 1SG2324
ATOM 2324 N MET 308 82, .949 27, .117 12, .757 1. .00 34, .67 1SG2325
ATOM 2325 CA MET 308 83 .787 28 .013 12 .014 1 .00 34 .67 1SG2326
ATOM 2326 CB MET 308 85 .288 27, .701 12 .143 1. .00 34 .67 1SG2327
ATOM 2327 CG MET 308 85. .829 27. .710 13, .578 1. .00 34, .67 1SG2328
ATOM 2328 SD MET 308 85. .764 29, .297 14 .458 1. .00 34 .67 1SG2329
ATOM 2329 CE MET 308 84 .015 29 .170 14 .927 1 .00 34 .67 1SG2330
ATOM 2330 C MET 308 83. .437 27, .855 10 .568 1, .00 34 .67 1SG2331
ATOM 2331 O MET 308 83 .435 26 .745 10 .035 1 .00 34 .67 1SG2332
ATOM 2332 N LYS 309 83. .128 28, .985 9, .901 1. .00 36, .38 1SG2333
ATOM 2333 CA LYS 309 82. .730 28, .995 8 .521 1. .00 36 .38 1SG2334
ATOM 2334 CB LYS 309 81 .225 29 .268 8 .352 1 .00 36 .38 1SG2335
ATOM 2335 CG LYS 309 80. .307 28 .176 8 .901 1. .00 36 .38 1SG2336
ATOM 2336 CD LYS 309 80. .343 26. .885 8. .086 1. .00 36, .38 1SG2337
ATOM 2337 CE LYS 309 79. .566 26, .997 6 .773 1 .00 36 .38 1SG2338
ATOM 2338 NZ LYS 309 79 .636 25, .722 6 .028 1, .00 36 .38 1SG2339
ATOM 2339 C LYS 309 83. .411 30, .164 7, .885 1. .00 36, .38 1SG2340
ATOM 2340 O LYS 309 83. .877 31. .071 8 .568 1. .00 36, .38 1SG2341
ATOM 2341 N THR 310 83. .454 30. .185 6, .541 1. .00 36, .71 1SG2342
ATOM 2342 CA THR 310 84, .092 31. .253 5 .828 1. .00 36, .71 1SG2343
ATOM 2343 CB THR 310 84, .048 31. .064 4 .341 1. .00 36, .71 1SG2344
ATOM 2344 OGl THR 310 84 , .833 32. .057 3 .697 1. .00 36. .71 1SG2345
ATOM 2345 CG2 THR 310 82. .586 31. .147 3, .873 1. ,00 36. .71 1SG2346
ATOM 2346 C THR 310 83 .376 32 .527 6 .153 1, .00 36 .71 1SG2347
ATOM 2347 O THR 310 83, .988 33, .592 6 .217 1, .00 36, .71 1SG2348
ATOM 2348 N GLY 311 82, .044 32, .460 6, .340 1. .00 37. .64 1SG2349
ATOM 2349 CA GLY 311 81, .314 33. .659 6, .639 1. .00 37, .64 1SG2350
ATOM 2350 C GLY 311 81. .799 34. .219 7 .940 1. .00 37. .64 1SG2351
ATOM 2351 O GLY 311 82. .072 35, .415 8, .036 1. .00 37. .64 1SG2352
ATOM 2352 N LYS 312 81. .911 33, .369 8 .982 1, .00 40, .59 1SG2353
ATOM 2353 CA LYS 312 82. .411 33. .825 10, .249 1. .00 40. .59 1SG2354
ATOM 2354 CB LYS 312 81. ,813 35. .150 10. .750 1. .00 40. .59 1SG2355
ATOM 2355 CG LYS 312 82. .713 35. .830 11 .784 1, .00 40. .59 1SG2356 ATOM 2356 CD LYS 312 84.,103 36.,176 11..234 1.,00 40.,59 1SG2357
ATOM 2357 CE LYS 312 84. .088 36. ,953 9. .914 1. .00 40. .59 1SG2358
ATOM 2358 NZ LYS 312 84. .079 38. .410 10. .178 1. ,00 40. .59 1SG2359
ATOM 2359 C LYS 312 82. .139 32. ,749 11. .252 1. ,00 40. .59 1SG2360
ATOM 2360 O LYS 312 81, .758 31. .638 10. .888 1. .00 40. .59 1SG2361
ATOM 2361 N SER 313 82. .344 33. .045 12. .552 1. .00 40. .92 1SG2362
ATOM 2362 CA SER 313 82. .167 32. .029 13. .549 1. .00 40. .92 1SG2363
ATOM 2363 CB SER 313 83. .291 32. ,025 14. .595 1. .00 40. .92 1SG2364
ATOM 2364 OG SER 313 84. .546 31. .883 13. .949 1, .00 40. .92 1SG2365
ATOM 2365 C SER 313 80. .904 32. .298 14. .301 1. .00 40. .92 1SG2366
ATOM 2366 O SER 313 80. .626 33. .433 14. .685 1. .00 40. .92 1SG2367
ATOM 2367 N LEU 314 80. .101 31. .240 14. .531 1. .00 43. .49 1SG2368
ATOM 2368 CA LEU 314 78, .897 31. .402 15. .295 1. .00 43. .49 1SG2369
ATOM 2369 CB LEU 314 77, .600 31. .004 14 , .570 1. .00 43. .49 1SG2370
ATOM 2370 CG LEU 314 77, .152 31. .976 13, .464 1, .00 43, .49 1SG2371
ATOM 2371 CD2 LEU 314 75, .709 31. .670 13, .032 1, .00 43, .49 1SG2372
ATOM 2372 CDl LEU 314 78, .140 32. .011 12, .288 1, .00 43, .49 1SG2373
ATOM 2373 C LEU 314 78, .990 30. .526 16. .502 1, .00 43, .49 1SG2374
ATOM 2374 O LEU 314 79 .581 29. .447 16 .452 1, .00 43 .49 1SG2375
ATOM 2375 N LEU 315 78, .417 30. .981 17. .638 1, .00 46 .60 1SG2376
ATOM 2376 CA LEU 315 78, .459 30. .165 18. .815 1, .00 46, .60 1SG2377
ATOM 2377 CB LEU 315 79 .288 30. .783 19 .962 1, .00 46 .60 1SG2378
ATOM 2378 CG LEU 315 79 .618 29. .813 21, .118 1, .00 46 .60 1SG2379
ATOM 2379 CD2 LEU 315 78 .362 29. .318 21, .849 1, .00 46 .60 1SG2380
ATOM 2380 CDl LEU 315 80, .627 30. .442 22, .091 1, .00 46 .60 1SG2381
ATOM 2381 C LEU 315 77 .048 29, .924 19 .253 1, .00 46 .60 1SG2382
ATOM 2382 O LEU • ■ 315 76 .219 30, .832 19, .219 1, .00 46 .60 1SG2383
ATOM 2383 N HIS 316 76 .722 28. .674 19, .650 1, .00 46 .58 1SG2384
ATOM 2384 CA HIS 316 75 .369 28. .388 20 .036 1 .00 46 .58 1SG2385
ATOM 2385 NDl HIS 316 74 .189 27, .895 17 .075 1, .00 46 .58 1SG2386
ATOM 2386 CG HIS 316 74 .908 27, .076 17 .916 1, .00 46 .58 1SG2387
ATOM 2387 CB HIS 316 74 .809 27, .100 19, .410 1, .00 46 .58 1SG2388
ATOM 2388 NE2 HIS 316 75 .458 26, .607 15 .780 1 .00 46 .58 1SG2389
ATOM 2389 CD2 HIS 316 75 .677 26, .296 17, .110 1, .00 46 .58 1SG2390
ATOM 2390 CE1 HIS 316 74 .557 27, .573 15, .809 1, .00 46 .58 1SG2391
ATOM 2391 C HIS 316 75 .315 28, .173 21 .516 1 .00 46 .58 1SG2392
ATOM 2392 o HIS 316 75 .719 27, .126 2 .017 1, .00 46 .58 1SG2393
ATOM 2393 N LEU 317 74 .784 29, .159 22 .261 1, .00 48 .33 1SG2394
ATOM 2394 CA LEU 317 74, .652 28. .995 23, .679 1, .00 48 .33 1SG2395
ATOM 2395 CB LEU 317 75 .000 30. .244 24 .508 1, .00 48 .33 1SG2396
ATOM 2396 CG LEU 317 74 .638 30. .094 26 .002 1, .00 48 .33 1SG2397
ATOM 2397 CD2 LEU 317 74 .772 31. .430 26, .751 1, .00 48 .33 1SG2398
ATOM 2398 CDl LEU 317 75 .423 28. .954 26 .670 1, .00 48 .33 1SG2399
ATOM 2399 C LEU 317 73 .224 28, .695 23 .978 1, .00 48 .33 1SG2400
ATOM 2400 O LEU 317 72 .307 29, .285 23, .410 1, .00 48 .33 1SG2401
ATOM 2401 N HIS 318 73 .018 27, .733 24, .890 1, .00 47, .43 1SG2402
ATOM 2402 CA HIS 318 71 .715 27 .373 25 .346 1, .00 47 .43 1SG2403
ATOM 2403 NDl HIS 318 73 .174 25, .128 23 .396 1, .00 47 .43 1SG2404
ATOM 2404 CG HIS 318 72 .585 25, .134 24, .641 1, .00 47 .43 1SG2405
ATOM 2405 CB HIS 318 71 .354 25 .932 24 .959 1 .00 47 .43 1SG2406
ATOM 2406 NE2 HIS 318 74 .419 23 .820 24 .690 1, .00 47 .43 1SG2407
ATOM 2407 CD2 HIS 318 73 .358 24, .329 25, .420 1, .00 47 .43 1SG2408
ATOM 2408 CE1 HIS 318 74 .265 24, .328 23, .481 1, .00 47, .43 1SG2409
ATOM 2409 C HIS 318 71 .779 27. .512 26 .826 1, .00 47 .43 1SG2410
ATOM 2410 O HIS 318 72 .632 26, .911 27, .478 1, .00 47 .43 1SG2411
ATOM 2411 N SER 319 70 .889 28, .342 27, .399 1, .00 44 .77 1SG2412
ATOM 2412 CA SER 319 70 .990 28, .554 28 .808 1, .00 44 .77 1SG2413 ATOM 2413 CB SER 319 71..436 29,.979 29..180 1.,00 44,.77 1SG2414
ATOM 2414 OG SER 319 70. .468 30. .924 28. .748 1. .00 44. .77 1SG2415
ATOM 2415 C SER 319 69. .661 28, .325 29. .426 1. .00 44. .77 1SG2416
ATOM 2416 O SER 319 68. .620 28. .438 28, .779 1. .00 44. .77 1SG2417
ATOM 2417 N THR 320 69. .683 27, .971 30 .722 1. .00 44, .09 1SG2418
ATOM 2418 CA THR 320 68. .465 27. .767 31, .435 1. .00 44, .09 1SG2419
ATOM 2419 CB THR 320 68. .460 26. .529 32, .281 1. .00 44, .09 1SG2420
ATOM 2420 OGl THR 320 69. .464 26. .617 33, .281 1. .00 44. .09 1SG2421
ATOM 2421 CG2 THR 320 68, .714 25, .312 31 .377 1. .00 44. .09 1SG2422
ATOM 2422 C THR 320 68. .349 28. .931 32 , .358 1. .00 44, .09 1SG2423
ATOM 2423 O THR 320 69, .272 29. .233 33, .113 1. .00 44, .09 1SG2424
ATOM 2424 N LEU 321 67 .208 29 .633 32 .294 1. .00 43, .16 1SG2425
ATOM 2425 CA LEU 321 67, .000 30. .773 33. .133 1. .00 43, .16 1SG2426
ATOM 2426 CB LEU 321 66 .507 31. .992 32 .325 1. .00 43 .16 1SG2427
ATOM 2427 CG LEU 321 66, .398 33, .321 33. .097 1. .00 43, .16 1SG2428
ATOM 2428 CD2 LEU 321 67, .781 33, .804 33 .561 1. .00 43 .16 1SG2429
ATOM 2429 CDl LEU 321 65, .346 33, .262 34. .217 1. .00 43, .16 1SG2430
ATOM 2430 C LEU 321 65, .913 30, .374 34 .078 1. .00 43 .16 1SG2431
ATOM 2431 O LEU 321 64. .817 30, .017 33. .653 1. .00 43 .16 1SG2432
ATOM 2432 N GLU 322 66. .189 30, .414 35 .394 1. .00 42 .66 1SG2433
ATOM 2433 CA GLU 322 65 .199 29 .991 36 .343 1. .00 42 .66 1SG2434
ATOM 2434 CB GLU 322 65, .692 28, .797 37 .175 1. .00 42 .66 1SG2435
ATOM 2435 CG GLU 322 64 .656 28, .176 38 .108 1. .00 42 .66 1SG2436
ATOM 2436 CD GLU 322 65, .359 27, .023 38 .811 1. .00 42 .66 1SG2437
ATOM 2437 OEl GLU 322 66, .612 26 .944 38 .697 1, .00 42 .66 1SG2438
ATOM 2438 OE2 GLU 322 64, .662 26, .206 39 .465 1. .00 42 .66 1SG2439
ATOM 2439 C GLU 322 64 .943 31 .129 37 .279 1, .00 42 .66 1SG2440
ATOM 2440 O GLU 322 65, .871 31, .812 37, .707 1. .00 42 .66 1SG2441
ATOM 2441 N MET 323 63 .663 31, .373 37 .623 1. .00 43 .39 1SG2442
ATOM 2442 CA MET 323 63 .398 32 .454 38 .527 1, .00 43 .39 1SG2443
ATOM 2443 CB MET 323 62 .374 33, .484 38 .012 1, .00 43 .39 1SG2444
ATOM 2444 CG MET 323 62 .917 34 .332 36 .857 1, .00 43 .39 1SG2445
ATOM 2445 SD MET 323 61, .822 35 .672 36 .299 1. .00 43 .39 1SG2446
ATOM 2446 CE MET 323 62 .017 36 .684 37 .793 1, .00 43 .39 1SG2447
ATOM 2447 C MET 323 62, .897 31, .880 39 .812 1. .00 43 .39 1SG2448
ATOM 2448 O MET 323 62 .122 30 .924 39 .826 1, .00 43 .39 1SG2449
ATOM 2449 N PHE 324 63, .366 32, .458 40, .936 1. .00 44, .34 1SG2450
ATOM 2450 CA PHE 324 63 .000 32 .004 42 .244 1. .00 44 .34 1SG2451
ATOM 2451 CB PHE 324 64, .209 31, .614 43 .113 1. ,00 44, .34 1SG2452
ATOM 2452 CG PHE 324 64, .985 30, .518 42 .466 1. .00 44, .34 1SG2453
ATOM 2453 CDl PHE 324 65 .869 30 .798 41 .449 1. .00 44 .34 1SG2454
ATOM 2454 CD2 PHE 324 64, .850 29, .218 42, .893 1. .00 44, .34 1SG2455
ATOM 2455 CE1 PHE 324 66, .595 29 .794 40 .854 1. .00 44, .34 1SG2456
ATOM 2456 CE2 PHE 324 65, .573 28, .210 42, .302 1. .00 44. .34 1SG2457
ATOM 2457 CZ PHE 324 66, .448 28 .496 41, .281 1. .00 44. .34 1SG2458
ATOM 2458 c PHE 324 62, .429 33, .190 42, .943 1. ,00 44. .34 1SG2459
ATOM 2459 O PHE 324 62, .780 34, .330 42, .642 1. ,00 44. .34 1SG2460
ATOM 2460 N ALA 325 61. .525 32. .951 43. .908 1. ,00 45. .61 1SG2461
ATOM 2461 CA ALA 325 61, .021 34. .048 44, .671 1. .00 45. .61 1SG2462
ATOM 2462 CB ALA 325 59, .540 33 .909 45, .062 1. .00 45. .61 1SG2463
ATOM 2463 C ALA 325 61, .827 34. .017 45, .920 1. ,00 45. .61 1SG2464
ATOM 2464 O ALA 325 62, .279 32. .955 46, .341 1. .00 45. .61 1SG2465
ATOM 2465 N ALA 326 62. .086 35. .184 46, .531 1. ,00 48. .64 1SG2466
ATOM 2466 CA ALA 326 62, .853 35, .118 47, .736 1. ,00 48. .64 1ΞG2467
ATOM 2467 CB ALA 326 63. .922 36. .218 47. .848 1. ,00 48. .64 1SG2468
ATOM 2468 C ALA 326 61. .898 35. .302 48. .866 1. .00 48, .64 1SG2469
ATOM 2469 O ALA 326 61. .208 36. .313 48. .962 1. ,00 48. .64 1SG2470 ATOM 2470 N ARG 327 61.841 34.302 49.758 1.00 51.40 1SG2471
ATOM 2471 CA ARG 327 60 .988 34 .334 50 .905 1 .00 51 .40 1SG2472
ATOM 2472 CB ARG 327 60 .721 32 .946 51 .514 1 .00 51 .40 1SG2473
ATOM 2473 CG ARG 327 59 .787 32 .972 52 .726 1 .00 51 .40 1SG2474
ATOM 2474 CD ARG 327 58 .324 33 .253 52 .372 1 .00 51 .40 1SG2475
ATOM 2475 NE ARG 327 58 .245 34 .634 51, .818 1 .00 51 .40 1SG2476
ATOM 2476 CZ ARG 327 57 .085 35 .072 51 .247 1 .00 51 .40 1SG2477
ATOM 2477 NHl ARG 327 56 .002 34 .244 51, .180 1, .00 51 .40 1SG2478
ATOM 2478 NH2 ARG 327 57 .008 36 .338 50, .743 1, .00 51 .40 1SG2479
ATOM 2479 C ARG 327 61 .688 35 .160 51, .933 1, .00 51 .40 1SG2480
ATOM 2480 O ARG 327 62. .883 35 .429 51, .825 1, .00 51, .40 1SG2481
ATOM 2481 N TRP 328 60 .949 35 .591 52 .968 1 .00 51 .71 1SG2482
ATOM 2482 CA TRP 328 61 .531 36 .443 53 .961 1 .00 51 .71 1SG2483
ATOM 2483 CB TRP 328 60 .550 36 .815 55 .086 1 .00 51 .71 1SG2484
ATOM 2484 CG TRP 328 61 .143 37 .717 56 .143 1 .00 51 .71 1SG2485
ATOM 2485 CD2 TRP 328 60 .428 38 .181 57 .299 1 .00 51 .71 1SG2486
ATOM 2486 CDl TRP 328 62 .395 38 .252 56, .225 1 .00 51 .71 1SG2487
ATOM 2487 NE1 TRP 328 62 .508 39 .016 57 .362 1 .00 51 .71 1SG2488
ATOM 2488 CE2 TRP 328 61 .304 38 .982 58, .032 1 .00 51 .71 1SG2489
ATOM 2489 CE3 TRP 328 59 .147 37 .957 57, .715 1 .00 51 .71 1SG2490
ATOM 2490 CZ2 TRP 328 60 .910 39 .572 59, .199 1, .00 51 .71 1SG2491
ATOM 2491 CZ3 TRP 328 58 .753 38 .554 58, .892 1, .00 51 .71 1SG2492
ATOM 2492 CH2 TRP 328 59 .618 39 .346 59, .619 1, .00 51 .71 1SG2493
ATOM 2493 C TRP 328 62, .690 35, .736 54, .591 1, .00 51 .71 1SG2494
ATOM 2494 O TRP 328 63, .744 36 .337 54, .799 1, .00 51 .71 1SG2495
ATOM 2495 N ARG 329 62, .543 34 .437 54, .915 1. .00 49 .99 1SG2496
ATOM 2496 CA ARG 329 63 .639 33 .798 55 .587 1 .00 49 .99 1SG2497
ATOM 2497 CB ARG 329 63 .179 32 .701 56, .560 1 .00 49 .99 1SG2498
ATOM 2498 CG ARG 329 62 .352 31 .607 55 .886 1 .00 49 .99 1SG2499
ATOM 2499 CD ARG 329 60 .879 31 .986 55, .729 1, .00 49 .99 1SG2500
ATOM 2500 NE ARG 329 60 .205 30 .892 54, .976 1, .00 49 .99 1SG2501
ATOM 2501 CZ ARG 329 58 .842 30 .827 54, .946 1, .00 49 .99 1SG2502
ATOM 2502 NHl ARG 329 58, .101 31, .747 55, .629 1, .00 49 .99 1SG2503
ATOM 2503 NH2 ARG 329 58, .221 29, .843 54, .232 1, .00 49 .99 1SG2504
ATOM 2504 C ARG 329 64, .559 33, .162 54, .594 1, .00 49, .99 1SG2505
ATOM 2505 O ARG 329 64, .984 32, .022 54. .775 1, .00 49, .99 1SG2506
ATOM 2506 N SER 330 64, .904 33, .907 53. .527 1. .00 47, .82 1SG2507
ATOM 2507 CA SER 330 65, .871 33, .514 52. .541 1. .00 47, .82 1SG2508
ATOM 2508 CB SER 330 67. .308 33, .406 53. .090 1. .00 47, .82 1SG2509
ATOM 2509 OG SER 330 67. .423 32. .318 53. .995 1. .00 47, .82 1SG2510
ATOM 2510 C SER 330 65. .500 32. .206 51. , 924 1. .00 47. .82 1SG2511
ATOM 2511 O SER 330 66. .304 31. .611 51, .207 1. .00 47, .82 1SG2512
ATOM 2512 N LYS 331 64. .268 31, .721 52. .153 1. .00 44, .44 1SG2513
ATOM 2513 CA LYS 331 63. .916 30, .485 51. .524 1. .00 44, .44 1SG2514
ATOM 2514 CB LYS 331 62. .784 29. .721 52. .232 1. .00 44. .44 1SG2515
ATOM 2515 CG LYS 331 63. .201 29. .154 53. .591 1. .00 44. .44 1SG2516
ATOM 2516 CD LYS 331 62. .028 28. .670 54. ,444 1. ,00 44. .44 1SG2517
ATOM 2517 CE LYS 331 62. .457 28. .071 55. ,786 1. ,00 44. .44 1SG2518
ATOM 2518 NZ LYS 331 63. .195 26. .808 55. .562 1. ,00 44. .44 1SG2519
ATOM 2519 C LYS 331 63. ,452 30. ,852 50. .163 1. ,00 44. .44 1SG2520
ATOM 2520 O LYS 331 62. ,857 31. ,907 49. ,970 1. ,00 44. ,44 1SG2521
ATOM 2521 N ALA 332 63. ,722 30. Oil 49. 155 1. 00 44. ,68 1SG2522
ATOM 2522 CA ALA 332 63. ,269 30. .439 47. 872 1. 00 44. ,68 1SG2523
ATOM 2523 CB ALA 332 64. ,369 30. ,437 46. 796 1. 00 44. 68 1SG2524
ATOM 2524 C ALA 332 62. 218 29. 491 47. 424 1. 00 44. 68 1SG2525
ATOM 2525 O ALA 332 62. 336 28. 282 47. 620 1. 00 44. 68 1SG2526
ATOM 2526 N PRO 333 61. ,165 30. ,022 46. 862 1. ,00 47. ,20 1SG2527 ATOM 2527 CA PRO 333 60..245 29,.127 46..254 1.00 47..20 1SG2528
ATOM 2528 CD PRO 333 60. .465 31, .143 47, .467 1. .00 47. .20 1SG2529
ATOM 2529 CB PRO 333 59. .056 29, .981 45, .840 1. ,00 47. .20 1SG2530
ATOM 2530 CG PRO 333 59. .010 31. .034 46, .969 1. ,00 47. .20 1SG2531
ATOM 2531 C PRO 333 61. .076 28. .512 45, .203 1. ,00 47. .20 1SG2532
ATOM 2532 0 PRO 333 61. .761 29. .252 44 .493 1. .00 47. .20 1SG2533
ATOM 2533 N MET 334 60. .994 27. .173 45, .091 1. ,00 46. .85 1SG2534
ATOM 2534 CA MET 334 61. .927 26. .427 44, .312 1. ,00 46, .85 1SG2535
ATOM 2535 CB MET 334 61. .550 24, .941 44, .198 1. ,00 46. .85 1SG2536
ATOM 2536 CG MET 334 61. .592 24, .200 45, .537 1. .00 46. .85 1SG2537
ATOM 2537 SD MET 334 61. .152 22, .440 45 .437 1. .00 46. .85 1SG2538
ATOM 2538 CE MET 334 62. .669 21, .957 44. .566 1. .00 46. .85 1SG2539
ATOM 2539 C MET 334 61. .940 26, .999 42 .955 1. .00 46, .85 1SG2540
ATOM 2540 0 MET 334 63. .008 27 .232 42 .391 1, .00 46, .85 1SG2541
ATOM 2541 N SER 335 60, .764 27, .276 4 .384 1. .00 48, .68 1SG2542
ATOM 2542 CA SER 335 60, .911 27, .856 41 .096 1, .00 48 .68 1SG2543
ATOM 2543 CB SER 335 61, .111 26, .816 39. .983 1. .00 48. .68 1SG2544
ATOM 2544 OG SER 335 62, .225 25, .987 40 .271 1. .00 48. .68 1SG2545
ATOM 2545 C SER 335 59, .654 28 .547 40 .745 1, .00 48 .68 1SG2546
ATOM 2546 0 SER 335 58. ,573 27, .968 40 .832 1, .00 48. .68 1SG2547
ATOM 2547 N LEU 336 59. .751 29 .828 40 .360 1, .00 46 .57 1SG2548
ATOM 2548 CA LEU 336 58. .557 30 .391 39 .834 1, .00 46 .57 1SG2549
ATOM 2549 CB LEU 336 58, .626 31, .910 39 .635 1, .00 46, .57 1SG2550
ATOM 2550 CG LEU 336 58, .655 32 .659 40 .977 1, .00 46 .57 1SG2551
ATOM 2551 CD2 LEU 336 57, .553 32, .141 41 .914 1. .00 46, .57 1SG2552
ATOM 2552 CDl LEU 336 58, .593 34 .178 40 .776 1, .00 46 .57 1SG2553
ATOM 2553 C LEU 336 58, .367 29 .726 38 .510 1, .00 46 .57 1SG2554
ATOM 2554 0 LEU 336 57, .293 29, .213 38 .203 1, .00 46 .57 1SG2555
ATOM 2555 N PHE 337 59 .447 29 .686 37 .699 1, .00 43 .34 1SG2556
ATOM 2556 CA PHE 337 59, .369 29, .038 36 .422 1, .00 43, .34 1SG2557
ATOM 2557 CB PHE 337 58, .478 29 .777 35 .407 1, .00 43 .34 1SG2558
ATOM 2558 CG PHE 337 58 .987 31 .166 35 .223 1 .00 43 .34 1SG2559
ATOM 2559 CDl PHE 337 60, .085 31, .409 34 .435 1, .00 43 .34 1SG2560
ATOM 2560 CD2 PHE 337 58, .356 32 .229 35 .828 1, .00 43 .34 1SG2561
ATOM 2561 CE1 PHE 337 60 .557 32 .686 34 .252 1 .00 43 .34 1SG2562
ATOM 2562 CE2 PHE 337 58, .821 33, .510 35 .651 1. .00 43 .34 1SG2563
ATOM 2563 CZ PHE 337 59, .921 33 .739 34 .861 1, .00 43 .34 1SG2564
ATOM 2564 C PHE 337 60, .745 28, .904 35 .848 1. .00 43 .34 1SG2565
ATOM 2565 0 PHE 337 61, .678 29 .590 36 .262 1, .00 43 .34 1SG2566
ATOM 2566 N LEU 338 60, .901 27 .985 34 .873 1, .00 4 .01 1SG2567
ATOM 2567 CA LEU 338 62. .179 27, .768 34 .259 1, .00 42 .01 1SG2568
ATOM 2568 CB LEU 338 62, .694 26, .330 34 .449 1, .00 42 .01 1SG2569
ATOM 2569 CG LEU 338 64. .063 26, .056 33. .800 1. .00 42, .01 1SG2570
ATOM 2570 CD2 LEU 338 64. .381 24, .552 33. .785 1, .00 42, .01 1SG2571
ATOM 2571 CDl LEU 338 65, .171 26 .892 34 .456 1, .00 42 .01 1SG2572
ATOM 2572 C LEU 338 62. .039 27, .998 32, .786 1. .00 42, .01 1SG2573
ATOM 2573 O LEU 338 61. .146 27, .444 32, .148 1. .00 42, .01 1SG2574
ATOM 2574 N LEU 339 62. .922 28 .835 32 .201 1, .00 42 .24 1SG2575
ATOM 2575 CA LEU 339 62. .862 29, .038 30, .781 1. .00 42, .24 1SG2576
ATOM 2576 CB LEU 339 62, .707 30, .486 30, .274 1. .00 42, .24 1SG2577
ATOM 2577 CG LEU 339 61. .252 30, .982 30, .182 1. .00 42, .24 1SG2578
ATOM 2578 CD2 LEU 339 61. .154 32, .246 29, .314 1. .00 42, .24 1SG2579
ATOM 2579 CDl LEU 339 60. .603 31, .139 31, .557 1. .00 42, .24 1SG2580
ATOM 2580 C LEU 339 64. .079 28. .495 30, .124 1. ,00 42. .24 1SG2581
ATOM 2581 0 LEU 339 65. ,164 28. .449 30, .704 1. .00 42, .24 1SG2582
ATOM 2582 N GLU 340 63. .888 28. .051 28, .867 1. .00 46, .15 1SG2583
ATOM 2583 CA GLU 340 64. .954 27. .532 28, .071 1. .00 46. .15 1SG2584 ATOM 2584 CB GLU 340 64,.598 26.206 27.370 1..00 46,.15 1SG2585
ATOM 2585 CG GLU 340 65 .737 25 .619 26 .533 1. .00 46 .15 1SG2586
ATOM 2586 CD GLU 340 65 .321 24 .234 26 .050 1. .00 46, .15 1SG2587
ATOM 2587 OEl GLU 340 64 .094 23 .954 26 .017 1. .00 46, .15 1SG2588
ATOM 2588 OE2 GLU 340 66 .234 23 .433 25 .709 1. .00 46, .15 1SG2589
ATOM 2589 C GLU 340 65 .206 28 .551 27 .013 1. .00 46. .15 1SG2590
ATOM 2590 O GLU 340 64 .323 28 .890 26 .226 1, .00 46. .15 1SG2591
ATOM 2591 N VAL 341 66 .441 29 .077 26 .983 1. .00 51. .18 1SG2592
ATOM 2592 CA VAL 341 66 .783 30 .075 26 .020 1. .00 51, .18 1SG2593
ATOM 2593 CB VAL 341 67 .483 31. .256 26 .614 1. .00 51, .18 1SG2594
ATOM 2594 CGI VAL 341 68 .027 32 .124 25 .465 1. .00 51, .18 1SG2595
ATOM 2595 CG2 VAL 341 66, .512 31 .980 27, .560 1, .00 51, .18 1SG2596
ATOM 2596 C VAL 341 67, .761 29 .466 25. .079 1. .00 51, .18 1SG2597
ATOM 2597 O VAL 341 68, .625 28 .684 25. .480 1. .00 51, .18 1SG2598
ATOM 2598 N HIS 342 67, .620 29, .823 23. .788 1. .00 58. .81 1SG2599
ATOM 2599 CA HIS 342 68, .537 29 .398 22. .779 1. .00 58. .81 1SG2600
ATOM 2600 NDl HIS 342 65, .521 28 .002 21. .186 1. .00 58. .81 1SG2601
ATOM 2601 CG HIS 342 66, .718 27, .764 21. .826 1. .00 58. .81 1SG2602
ATOM 2602 CB HIS 342 67, .928 28, .625 21. .588 1. .00 58. .81 1SG2603
ATOM 2603 NE2 HIS 342 65, .212 26, .201 22. .449 1. .00 58, .81 1SG2604
ATOM 2604 CD2 HIS 342 66, .512 26, .661 22. .597 1. .00 58, .81 1SG2605
ATOM 2605 CE1 HIS 342 64, .657 27, .039 21, .592 1. .00 58, .81 1SG2606
ATOM 2606 C HIS 342 68 .928 30 .687 22 .133 1. .00 58 .81 1SG2607
ATOM 2607 o HIS 342 68 .155 31 .644 22 .133 1. .00 58 .81 1SG2608
ATOM 2608 N PHE 343 70 .142 30 .739 21 .565 1, .00 62 .75 1SG2609
ATOM 2609 CA PHE 343 70 .626 31 .906 20 .897 1. .00 62 .75 1SG2610
ATOM 2610 CB PHE 343 71 .556 32 .773 21 .759 1. .00 62 .75 1SG2611
ATOM 2611 CG PHE 343 70 .799 33 .810 22 .474 1, .00 62 .75 1SG2612
ATOM 2612 CDl PHE 343 70, .520 34 .964 21 .786 1. .00 62 .75 1SG2613
ATOM 2613 CD2 PHE 343 70, .405 33 .656 23 .779 1. .00 62 .75 1SG2614
ATOM 2614 CE1 PHE 343 69, .832 35 .977 22 .393 1. .00 62 .75 1SG2615
ATOM 2615 CE2 PHE 343 69, .715 34 .664 24 .396 1. .00 62 .75 1SG2616
ATOM 2616 CZ PHE 343 69, .436 35 .808 23 .697 1. .00 62, .75 1SG2617
ATOM 2617 C PHE 343 71, .558 31 .456 19, .842 1. .00 62, .75 1SG2618
ATOM 2618 0 PHE 343 71, .969 30, .298 19, .794 1. .00 62, .75 1SG2619
ATOM 2619 N ASN 344 71, .893 32, .403 18, .955 1. .00 62 , .02 1SG2620
ATOM 2620 CA ASN 344 72 , .961 32 .230 18. .032 1. .00 62 , .02 1SG2621
ATOM 2621 CB ASN 344 72 , .584 31, .777 16. .607 1. .00 62. .02 1SG2622
ATOM 2622 CG ASN 344 71. .442 32, .599 16, .059 1. .00 62. .02 1SG2623
ATOM 2623 ODl ASN 344 70. .422 32, .777 16, .723 1. .00 62. .02 1SG2624
ATOM 2624 ND2 ASN 344 71. .603 33, .094 14, .804 1. ,00 62. .02 1SG2625
ATOM 2625 C ASN 344 73. .730 33. .503 18, .141 1. ,00 62. .02 1SG2626
ATOM 2626 O ASN 344 73. .162 34. .583 18, .299 1. ,00 62. .02 1SG2627
ATOM 2627 N LEU 345 75. .063 33. .365 18. .134 1. .00 60. .56 1SG2628
ATOM 2628 CA LEU 345 75. .976 34. .383 18. .545 1. ,00 60. .56 1SG2629
ATOM 2629 CB LEU 345 76. .490 33 .860 19. .909 1. .00 60. .56 1SG2630
ATOM 2630 CG LEU 345 77. .782 34. .400 20. .508 1. .00 60. .56 1SG2631
ATOM 2631 CD2 LEU 345 77. .828 35 .896 20. .390 1. .00 60. .56 1SG2632
ATOM 2632 CDl LEU 345 79. .013 33. .753 19. .875 1. .00 60. .56 1SG2633
ATOM 2633 C LEU 345 77. .080 34. .524 17. .549 1. .00 60. .56 1SG2634
ATOM 2634 O LEU 345 77. .503 33. .550 16. .934 1. ,00 60. .56 1SG2635
ATOM 2635 N LYS 346 77. .570 35. .765 17. .356 1. ,00 54. .79 1SG2636
ATOM 2636 CA LYS 346 78. .652 36. .000 16. .447 1. ,00 54. .79 1SG2637
ATOM 2637 CB LYS 346 78. ,419 37. .256 15. .587 1. ,00 54. .79 1SG2638
ATOM 2638 CG LYS 346 79. ,537 37. .608 14. .604 1. ,00 54. .79 1SG2639
ATOM 2639 CD LYS 346 80. .786 38. .157 15. .293 1. 00 54. .79 1SG2640
ATOM 2640 CE LYS 346 81. .736 38. .910 14. .357 1. 00 54. .79 1SG2641 ATOM 2641 NZ LYS 346 82..849 38..035 13 ,.934 1..00 54..79 1SG2642
ATOM 2642 C LYS 346 79, .877 36. .160 17, .283 1. .00 54. .79 1SG2643
ATOM 2643 O LYS 346 79, .867 36. .856 18, .297 1. .00 54. .79 1SG2644
ATOM 2644 N VAL 347 80, .968 35. .476 16, .893 1. .00 48. .23 1SG2645
ATOM 2645 CA VAL 347 82, .160 35. .548 17. .681 1. .00 48, .23 1SG2646
ATOM 2646 CB VAL 347 82, .744 34, .203 17. .998 1. .00 48, .23 1SG2647
ATOM 2647 CGI VAL 347 84, .048 34, .404 18, .784 1. .00 48, .23 1SG2648
ATOM 2648 CG2 VAL 347 81, .698 33, .366 18, .744 1. .00 48. .23 1SG2649
ATOM 2649 C VAL 347 83. .196 36. .261 16, .876 1. .00 48, .23 1SG2650
ATOM 2650 O VAL 347 83, .542 35. .834 15. .775 1. .00 48. .23 1SG2651
ATOM 2651 N GLN 348 83, .721 37. .373 17. .423 1. .00 43. .66 1SG2652
ATOM 2652 CA GLN 348 84 .774 38. .090 16. .769 1, .00 43 .66 1SG2653
ATOM 2653 CB GLN 348 84 .752 39. .603 17, .043 1. .00 43. .66 1SG2654
ATOM 2654 CG GLN 348 85 .882 40. .361 16, .347 1. .00 43. .66 1SG2655
ATOM 2655 CD GLN 348 85 .588 40. .393 14, .854 1. .00 43. .66 1SG2656
ATOM 2656 OEl GLN 348 84, .642 41, .040 14, .410 1. .00 43. .66 1SG2657
ATOM 2657 NE2 GLN 348 86, .423 39, .675 14, .056 1. .00 43. .66 1SG2658
ATOM 2658 C GLN 348 86, .049 37, .548 17, .336 1, .00 43. .66 1SG2659
ATOM 2659 O GLN 348 86, .108 37, .186 18, .510 1. .00 43 .66 1SG2660
ATOM 2660 N TYR 349 87, .103 37, .461 16, .503 1. .00 38 .01 1SG2661
ATOM 2661 CA TYR 349 88. .343 36. .879 16, .934 1. .00 38 .01 1SG2662
ATOM 2662 CB TYR 349 88, .585 35. .584 16, .135 1. .00 38 .01 1SG2663
ATOM 2663 CG TYR 349 89, .830 34. .856 16, .505 1. .00 38 .01 1SG2664
ATOM 2664 CDl TYR 349 91, .069 35. .393 16. .264 1. .00 38, .01 1SG2665
ATOM 2665 CD2 TYR 349 89, .749 33. .595 17. .050 1. .00 38, .01 1SG2666
ATOM 2666 CE1 TYR 349 92. .212 34. .701 16. .583 1. .00 38, .01 1SG2667
ATOM 2667 CE2 TYR 349 90. .887 32, .894 17 .372 1, .00 38 .01 1SG2668
ATOM 2668 CZ TYR 349 92. .122 33, .448 17. .138 1. .00 38 .01 1SG2669
ATOM 2669 OH TYR 349 93, .298 32. .738 17. .459 1. .00 38 .01 1SG2670
ATOM 2670 C TYR 349 89, .442 37, .846 16. .602 1, .00 38 .01 1SG2671
ATOM 2671 O TYR 349 89, .547 38, .308 15. .465 1. .00 38 .01 1SG2672
ATOM 2672 N SER 350 90, .298 38. .172 17. .594 1. .00 34 .32 1SG2673
ATOM 2673 CA SER 350 91, .384 39. .089 17. .372 1, .00 34, .32 1SG2674
ATOM 2674 CB SER 350 91. .067 40. .535 17, .790 1. .00 34, .32 1SG2675
ATOM 2675 OG SER 350 90. .031 41. .064 16, .976 1. .00 34, .32 1SG2676
ATOM 2676 C SER 350 92. .531 38. .633 18, .218 1. .00 34 , .32 1SG2677
ATOM 2677 O SER 350 92. .391 37. .712 19. .021 1. .00 34, .32 1SG2678
ATOM 2678 N VAL 351 93. .717 39. .253 18. .043 1. .00 34 , .51 1SG2679
ATOM 2679 CA VAL 351 94. .836 38. .836 18. .838 1. .00 34. .51 1SG2680
ATOM 2680 CB VAL 351 95. .887 38. ,103 18. .056 1. .00 34. .51 1SG2681
ATOM 2681 CGI VAL 351 97. .082 37. .821 18. .982 1. .00 34. .51 1SG2682
ATOM 2682 CG2 VAL 351 95, .254 36. .837 17, .454 1, .00 34, .51 1SG2683
ATOM 2683 C VAL 351 95. .499 40. .037 19, .434 1. .00 34. .51 1SG2684
ATOM 2684 O VAL 351 95. .630 41. .081 18. .798 1. .00 34. .51 1SG2685
ATOM 2685 N HIS 352 95. .929 39. .900 20. .703 1. .00 36. .13 1SG2686
ATOM 2686 CA HIS 352 96. .655 40. .934 21. .379 1. .00 36. .13 1SG2687
ATOM 2687 NDl HIS 352 97. .557 42. .553 24. .159 1. .00 36. .13 1SG2688
ATOM 2688 CG HIS 352 96. .631 42. ,737 23. .157 1. ,00 36. .13 1SG2689
ATOM 2689 CB HIS 352 95. .865 41. ,624 22. .503 1. ,00 36. .13 1SG2690
ATOM 2690 NE2 HIS 352 97. .475 44. ,740 23. .765 1. ,00 36. .13 1SG2691
ATOM 2691 CD2 HIS 352 96. ,594 44. ,079 22. ,928 1. .00 36. .13 1SG2692
ATOM 2692 CE1 HIS 352 98. ,030 43. ,783 24. ,486 1. .00 36. .13 1SG2693
ATOM 2693 C HIS 352 97. ,806 40. ,232 22. ,013 1. .00 36. .13 1SG2694
ATOM 2694 O HIS 352 97. ,625 39. 168 22. ,607 1. .00 36. .13 1SG2695
ATOM 2695 N GLU 353 99. 026 40. 796 21. 893 1. 00 40. 08 1SG2696
ATOM 2696 CA GLU 353 100. 144 40. 105 22. ,459 1. 00 40. ,08 1SG2697
ATOM 2697 CB GLU 353 100. .015 39. ,877 23. ,976 1. .00 40. ,08 1SG2698 ATOM 2698 CG GLU 353 101,.304 39..387 24,.639 1..00 40..08 1SG2699
ATOM 2699 CD GLU 353 101. .117 39, .492 26, .147 1. .00 40. .08 1SG2700
ATOM 2700 OEl GLU 353 100. .513 40, .503 26, .596 1. .00 40. .08 1SG2701
ATOM 2701 OE2 GLU 353 101. .573 38, .566 26, .868 1. .00 40. .08 1SG2702
ATOM 2702 C GLU 353 100. .188 38, . 191 21, .741 1. .00 40. .08 1SG2703
ATOM 2703 O GLU 353 100. .058 38, .757 20, .519 1. .00 40. .08 1SG2704
ATOM 2704 N ASN 354 100. .418 37 .691 22 .470 1, .00 42, .91 1SG2705
ATOM 2705 CA ASN 354 100. .335 36, .425 21 .804 1, .00 42. .91 1SG2706
ATOM 2706 CB ASN 354 101. .601 35. .573 21, .963 1, .00 42. .91 1SG2707
ATOM 2707 CG ASN 354 102. .694 36 .259 21 .159 1, .00 42. .91 1SG2708
ATOM 2708 ODl ASN 354 102, .426 37. .139 20 .341 1, .00 42, .91 1SG2709
ATOM 2709 ND2 ASN 354 103. .965 35, .840 21, .389 1, .00 42, .91 1SG2710
ATOM 2710 C ASN 354 99. .197 35. .701 22, .443 1. .00 42. .91 1SG2711
ATOM 2711 O ASN 354 99. .378 34. .663 23 .080 1, .00 42. .91 1SG2712
ATOM 2712 N GLN 355 97, .975 36. .237 22 .262 1, .00 42. .52 1SG2713
ATOM 2713 CA GLN 355 96. .828 35. .644 22, .877 1, .00 42. .52 1SG2714
ATOM 2714 CB GLN 355 96. .308 36. .457 24 .075 1, .00 42. .52 1SG2715
ATOM 2715 CG GLN 355 97, .306 36. .531 25, .232 1, .00 42, .52 1SG2716
ATOM 2716 CD GLN 355 96. .708 37. .415 26, .316 1, .00 42, .52 1SG2717
ATOM 2717 OEl GLN 355 97. .257 37 .535 27 .410 1, .00 42 .52 1SG2718
ATOM 2718 NE2 GLN 355 95. .550 38 .056 26 .005 1, .00 42 .52 1SG2719
ATOM 2719 C GLN 355 95. .733 35, .606 21, .864 1, .00 42, .52 1SG2720
ATOM 2720 O GLN 355 95. .741 36 .349 20 .884 1 .00 42 .52 1SG2721
ATOM 2721 N LEU 356 94, .764 34, .702 22 .088 1, .00 41, .15 1SG2722
ATOM 2722 CA LEU 356 93, .635 34, .555 21, .224 1, .00 41, .15 1SG2723
ATOM 2723 CB LEU 356 93. .384 33, .063 20, .921 1, .00 41, .15 1SG2724
ATOM 2724 CG LEU 356 92. .195 32 .704 20 .011 1, .00 41 .15 1SG2725
ATOM 2725 CD2 LEU 356 90. .837 33, .121 20, .589 1, .00 41, .15 1SG2726
ATOM 2726 CDl LEU 356 92. .219 31, .203 19. .703 1, .00 41, .15 1SG2727
ATOM 2727 C LEU 356 92. .482 35 .109 22 .002 1, .00 41 .15 1SG2728
ATOM 2728 0 LEU 356 92. .093 34, .551 23 .027 1, .00 41 .15 1SG2729
ATOM 2729 N GLN 357 91. .904 36, .235 21. .536 1. .00 37, .64 1SG2730
ATOM 2730 CA GLN 357 90. .822 36 .844 22 .259 1, .00 37 .64 1SG2731
ATOM 2731 CB GLN 357 91. .094 38, .302 22 .656 1. .00 37 .64 1SG2732
ATOM 2732 CG GLN 357 91. .227 39, .230 21. .447 1, .00 37, .64 1SG2733
ATOM 2733 CD GLN 357 91. .488 40 .636 21 .962 1, .00 37 .64 1SG2734
ATOM 2734 OEl GLN 357 92, .332 40, .846 22 .831 1, .00 37, .64 1SG2735
ATOM 2735 NE2 GLN 357 90. .735 41, .628 21. .416 1. .00 37, .64 1SG2736
ATOM 2736 C GLN 357 89. ,629 36, .873 21, .363 1. .00 37, .64 1SG2737
ATOM 2737 O GLN 357 89. .757 36. .780 20 .143 1. .00 37, .64 1SG2738
ATOM 2738 N MET 358 88. .425 36. .987 21, .959 1. .00 35, .29 1SG2739
ATOM 2739 CA MET 358 87. .238 37. .036 21, .159 1. .00 35, .29 1SG2740
ATOM 2740 CB MET 358 86. .629 35. .649 20 .872 1, .00 35, .29 1SG2741
ATOM 2741 CG MET 358 87. .459 34. .813 19, .891 1. .00 35. .29 1SG2742
ATOM 2742 SD MET 358 86. ,793 33. .161 19. .520 1. .00 35. .29 1SG2743
ATOM 2743 CE MET 358 87. .644 32. .316 20. .884 1. .00 35. .29 1SG2744
ATOM 2744 C MET 358 86. .199 37. .851 21. .863 1. .00 35. .29 1SG2745
ATOM 2745 0 MET 358 86. ,344 38. .202 23. .033 1. ,00 35. .29 1SG2746
ATOM 2746 N ALA 359 85. .123 38. .190 21. .123 1. .00 35. .78 1SG2747
ATOM 2747 CA ALA 359 84. .027 38, .953 21. .645 1. .00 35. .78 1SG2748
ATOM 2748 CB ALA 359 83. .923 40. .372 21. .061 1. .00 35. .78 1SG2749
ATOM 2749 C ALA 359 82. .778 38. .227 21, .254 1. .00 35, .78 1SG2750
ATOM 2750 0 ALA 359 82. .740 37. .505 20, .258 1. .00 35. .78 1SG2751
ATOM 2751 N THR 360 81. ,719 38. .407 22. .060 1. .00 37. .29 1SG2752
ATOM 2752 CA THR 360 80. ,466 37. .731 21. .889 1. .00 37. .29 1SG2753
ATOM 2753 CB THR 360 80. .102 37. .059 23. .190 1. ,00 37. .29 1SG2754
ATOM 2754 OGl THR 360 81. .087 36. .095 23. .530 1. ,00 37. .29 1SG2755 ATOM 2755 CG2 THR 360 78.,706 36..427 23..137 1.00 37..29 1SG2756
ATOM 2756 C THR 360 79. .411 38. .769 21. .613 1. .00 37, .29 1SG2757
ATOM 2757 0 THR 360 79. .320 39. .768 22. .324 1. ,00 37, .29 1SG2758
ATOM 2758 N SER 361 78. .596 38. .562 20. .555 1. ,00 39. .69 1SG2759
ATOM 2759 CA SER 361 77. .473 39. .401 20. .225 1. ,00 39. .69 1SG2760
ATOM 2760 CB SER 361 77. .696 40. .230 18. .953 1. ,00 39. .69 1SG2761
ATOM 2761 OG SER 361 76. .536 40, .999 18. .675 1. .00 39, .69 1SG2762
ATOM 2762 C SER 361 76, .282 38. .515 19. .945 1. ,00 39, .69 1SG2763
ATOM 2763 0 SER 361 76, .305 37. .692 19. .032 1. ,00 39, .69 1SG2764
ATOM 2764 N LEU 362 75. .181 38. .680 20. .711 1. ,00 43, .87 1SG2765
ATOM 2765 CA LEU 362 74. .021 37. .845 20. .521 1. ,00 43. .87 1SG2766
ATOM 2766 CB LEU 362 73, .201 37. .592 21. .802 1. .00 43. .87 1SG2767
ATOM 2767 CG LEU 362 73, .950 36. .840 22, .917 1. .00 43, .87 1SG2768
ATOM 2768 CD2 LEU 362 75, .123 37. .668 23, .462 1. .00 43, .87 1SG2769
ATOM 2769 CDl LEU 362 74. .354 35. .425 22 , .476 1. .00 43. .87 1SG2770
ATOM 2770 C LEU 362 73, .071 38. .490 19, .563 1. ,00 43. .87 1SG2771
ATOM 2771 0 LEU 362 73, .056 39. .709 19, .401 1. .00 43 .87 1SG2772
ATOM 2772 N ASP 363 72, .250 37, .661 18, .884 1. .00 48 .95 1SG2773
ATOM 2773 CA ASP 363 71, .252 38, .184 17, .999 1. .00 48 .95 1SG2774
ATOM 2774 CB ASP 363 71, .125 37. .441 16, .658 1. .00 48. .95 1SG2775
ATOM 2775 CG ASP 363 70, .570 38. .457 15, .669 1. .00 48. .95 1SG2776
ATOM 2776 ODl ASP 363 70 .492 39. .654 16 .054 1. .00 48 .95 1SG2777
ATOM 2777 OD2 ASP 363 70, .231 38, .062 14 .521 1. .00 48 .95 1SG2778
ATOM 2778 C ASP 363 69, .943 38, .094 18, .727 1. .00 48 .95 1SG2779
ATOM 2779 0 ASP 363 69, .907 38, .160 19, .955 1. .00 48 .95 1SG2780
ATOM 2780 N ARG 364 68, .823 37, .941 17. .987 1. .00 52 .01 1SG2781
ATOM 2781 CA ARG 364 67 .544 37. .860 18 .636 1. .00 52 .01 1SG2782
ATOM 2782 CB ARG 364 66 .344 37, .635 17 .690 1. .00 52 .01 1SG2783
ATOM 2783 CG ARG 364 65 .807 38, .910 17. .029 1, .00 52 .01 1SG2784
ATOM 2784 CD ARG 364 64, .510 38, .689 16, .241 1. .00 52 .01 1SG2785
ATOM 2785 NE ARG 364 63. .924 40, .027 15, .935 1. .00 52 .01 1SG2786
ATOM 2786 CZ ARG 364 62 .817 40 .125 15 .140 1, .00 52 .01 1SG2787
ATOM 2787 NHl ARG 364 62 .284 39, .006 14 .570 1, .00 52 .01 1SG2788
ATOM 2788 NH2 ARG 364 62 .239 41, .343 14, .919 1, .00 52 .01 1SG2789
ATOM 2789 C ARG 364 67. .583 36, .728 19, .602 1, .00 52 .01 1SG2790
ATOM 2790 0 ARG 364 68, .225 35. .703 19, .372 1, .00 52 .01 1SG2791
ATOM 2791 N LEU 365 66 .890 36 .917 20 .739 1, .00 57 .21 1SG2792
ATOM 2792 CA LEU 365 66 .907 35. .955 21 .791 1, .00 57 .21 1SG2793
ATOM 2793 CB LEU 365 66 .646 36. .609 23 .158 1, .00 57 .21 1SG2794
ATOM 2794 CG LEU 365 67 .435 37. .910 23, .412 1. .00 57 .21 1SG2795
ATOM 2795 CD2 LEU 365 67, .539 38. .211 24, .913 1. .00 57 .21 1SG2796
ATOM 2796 CDl LEU 365 66 .898 39 .083 22 .579 1. .00 57 .21 1SG2797
ATOM 2797 C LEU 365 65 .722 35, .083 21, .585 1, .00 57 .21 1SG2798
ATOM 2798 0 LEU 365 64 .587 35, .542 21, .694 1. .00 57 .21 1SG2799
ATOM 2799 N LEU 366 65, .932 33, .794 21, .278 1. .00 58 .26 1SG2800
ATOM 2800 CA LEU 366 64, .756 32, .991 21, .282 1. .00 58. .26 1SG2801
ATOM 2801 CB LEU 366 64 .711 31, .914 20, .187 1, .00 58 .26 1SG2802
ATOM 2802 CG LEU 366 63 .298 31, .329 20, .018 1, .00 58 .26 1SG2803
ATOM 2803 CD2 LEU 366 63, .280 30, .144 19, .041 1. .00 58 .26 1SG2804
ATOM 2804 CDl LEU 366 62, .310 32, .435 19, .607 1. .00 58 .26 1SG2805
ATOM 2805 C LEU 366 64, .898 32. .352 22, .609 1. .00 58, .26 1SG2806
ATOM 2806 0 LEU 366 64 .897 31. .135 22, .783 1. .00 58 .26 1SG2807
ATOM 2807 N SER 367 65 .021 33. .243 23, .603 1. .00 55 .12 1SG2808
ATOM 2808 CA SER 367 65, .245 32. .933 24, .973 1. .00 55 .12 1SG2809
ATOM 2809 CB SER 367 65, .548 34. .190 25. .807 1. .00 55, .12 1SG2810
ATOM 2810 OG SER 367 64, .433 35. .070 25. .784 1. ,00 55, .12 1SG2811
ATOM 2811 C SER 367 64 .000 32. .350 25, .502 1. .00 55 .12 1SG2812 ATOM 2812 O SER 367 63..913 32,.004 26,.679 1..00 55..12 1SG2813
ATOM 2813 N LEU 368 62. .975 32, .238 24, .648 1. .00 53. .85 1SG2814
ATOM 2814 CA LEU 368 61. .777 31, .854 25, .279 1. .00 53. .85 1SG2815
ATOM 2815 CB LEU 368 60. .645 32, .850 24, .992 1. .00 53. .85 1SG2816
ATOM 2816 CG LEU 368 61. .013 34, .310 25, .339 1. .00 53. .85 1SG2817
ATOM 2817 CD2 LEU 368 59. .768 35, .199 25, .458 1. .00 53. .85 1SG2818
ATOM 2818 CDl LEU 368 62. .048 34, .884 24, .356 1. .00 53. .85 1SG2819
ATOM 2819 C LEU 368 61. .316 30, .501 24, .877 1. .00 53. .85 1SG2820
ATOM 2820 O LEU 368 61. .013 30, .229 23, .717 1. .00 53. .85 1SG2821
ATOM 2821 N SER 369 61. .254 29, .624 25, .891 1. .00 47. .90 1SG2822
ATOM 2822 CA SER 369 60. .694 28, .316 25, .806 1. .00 47. .90 1SG2823
ATOM 2823 CB SER 369 61. .681 27 .228 25 .357 1. .00 47. .90 1SG2824
ATOM 2824 OG SER 369 61. .022 25 .971 25 .302 1. .00 47. .90 1SG2825
ATOM 2825 C SER 369 60. .321 28 .033 27 .220 1. .00 47, .90 1SG2826
ATOM 2826 O SER 369 61. .108 28 .297 28 .127 1. .00 47 .90 1SG2827
ATOM 2827 N ARG 370 59. .111 27 .504 27 .464 1. .00 43 .87 1SG2828
ATOM 2828 CA ARG 370 58. .753 27 .283 28 .833 1 .00 43 .87 1SG2829
ATOM 2829 CB ARG 370 57. .293 27 .651 29 .146 1. .00 43 .87 1SG2830
ATOM 2830 CG ARG 370 56. .999 29 .147 29 .034 1, .00 43 .87 1SG2831
ATOM 2831 CD ARG 370 55. .546 29 .513 29 .345 1 .00 43 .87 1SG2832
ATOM 2832 NE ARG 370 54. .698 28 .963 28 .249 1 .00 43 .87 1SG2833
ATOM 2833 CZ ARG 370 54. .229 27 .683 28 .317 1 .00 43 .87 1SG2834
ATOM 2834 NHl ARG 370 54. .534 26 .899 29 .392 1 .00 43 .87 1SG2835
ATOM 2835 NH2 ARG 370 53, .450 27 .188 27 .311 1 .00 43 .87 1SG2836
ATOM 2836 C ARG 370 58, .901 25 .825 29 .117 1, .00 43 .87 1SG2837
ATOM 2837 O ARG 370 58, .136 25 .008 28 .607 1, .00 43 .87 1SG2838
ATOM 2838 N LYS 371 59, .922 25 .454 29 .916 1, .00 39 .81 1SG2839
ATOM 2839 CA LYS 371 60, .076 24 .071 30 .258 1, .00 39 .81 1SG2840
ATOM 2840 CB LYS 371 61, .404 23 .746 30 .965 1, .00 39, .81 1SG2841
ATOM 2841 CG LYS 371 62, .623 23 .785 30 .040 1, .00 39 .81 1SG2842
ATOM 2842 CD LYS 371 63, .955 23. .624 30 .777 1, .00 39 .81 1SG2843
ATOM 2843 CE LYS 371 65, .159 23 .473 29 .844 1. .00 39 .81 1SG2844
ATOM 2844 NZ LYS 371 66, .392 23 .261 30 .635 1. .00 39 .81 1SG2845
ATOM 2845 C LYS 371 58, .970 23. .671 31 .178 1, .00 39, .81 1SG2846
ATOM 2846 O LYS 371 58. .293 22. .670 30 .950 1, .00 39, .81 1SG2847
ATOM 2847 N SER 372 58. .751 24. .460 32, .249 1, .00 40, .06 1SG2848
ATOM 2848 CA SER 372 57. .713 24. .145 33 .185 1, .00 40, .06 1SG2849
ATOM 2849 CB SER 372 58. .026 22. .924 34, .067 1. .00 40, .06 1SG2850
ATOM 2850 OG SER 372 56. .951 22. .683 34, .962 1, .00 40, .06 1SG2851
ATOM 2851 C SER 372 57. .561 25, .316 34, .095 1. .00 40, .06 1SG2852
ATOM 2852 O SER 372 58. .461 26, .148 34, .206 1. .00 40. .06 1SG2853
ATOM 2853 N SER 373 56. .399 25, .420 34, .772 1. .00 42 , .37 1SG2854
ATOM 2854 CA SER 373 56. .220 26, .525 35, .663 1. .00 42. .37 1SG2855
ATOM 2855 CB SER 373 55. .545 27. .734 34. .994 1. .00 42. .37 1SG2856
ATOM 2856 OG SER 373 55. .395 28. .792 35. .928 1. .00 42. .37 1SG2857
ATOM 2857 C SER 373 55. .342 26. .092 36. .795 1. .00 42. .37 1SG2858
ATOM 2858 O SER 373 54. ,368 25. .365 36. .600 1. .00 42. .37 1SG2859
ATOM 2859 N SER 374 55. ,700 26. .513 38. .025 1. .00 44. .19 1SG2860
ATOM 2860 CA SER 374 54. ,908 26. .243 39. .192 1. .00 44. .19 1SG2861
ATOM 2861 CB SER 374 55. ,677 26. .486 40. .502 1. .00 44. .19 1SG2862
ATOM 2862 OG SER 374 56. ,763 25. .576 40. .605 1. .00 44. .19 1SG2863
ATOM 2863 C SER 374 53. ,751 27. .193 39. .166 1. .00 44. .19 1SG2864
ATOM 2864 O SER 374 52. 681 26. .931 39. .713 1. .00 44. .19 1SG2865
ATOM 2865 N ILE 375 53. 986 28. .339 38. .508 1. .00 48. .60 1SG2866
ATOM 2866 CA ILE 375 53. 123 29. ,472 38. .341 1. ,00 48. .60 1SG2867
ATOM 2867 CB ILE 375 53. 806 30. ,564 37. ,573 1. 00 48. .60 1SG2868
ATOM 2868 CG2 ILE 375 52. ,828 31. .732 37. .515 1. ,00 48. .60 1SG2869 ATOM 2869 CGI ILE 375 55..133 30..979 38..217 1..00 48..60 1SG2870
ATOM 2870 CDl ILE 375 54. .958 31. .678 39. .560 1. .00 48. .60 1SG2871
ATOM 2871 C ILE 375 51. ,923 29. .092 37. .534 1. ,00 48. .60 1SG2872
ATOM 2872 O ILE 375 50. .848 29. ,664 37. .704 1. .00 48. .60 1SG2873
ATOM 2873 N GLY 376 52. .087 28. .160 36. .580 1. .00 43. .39 1SG2874
ATOM 2874 CA GLY 376 51. .001 27. .810 35. ,713 1. ,00 43. .39 1SG2875
ATOM 2875 C GLY 376 51. ,401 28. .315 34. ,369 1. ,00 43. .39 1SG2876
ATOM 2876 O GLY 376 52. .339 29. .101 34. .256 1. .00 43. .39 1SG2877
ATOM 2877 N ASN 377 50. .702 27. .865 33, .310 1. .00 40. .27 1SG2878
ATOM 2878 CA ASN 377 51. .083 28. .242 31, .980 1. ,00 40. .27 1SG2879
ATOM 2879 CB ASN 377 50. .337 27, .460 30, .885 1. .00 40. .27 1SG2880
ATOM 2880 CG ASN 377 50. .775 26. .004 30. .963 1. .00 40. .27 1SG2881
ATOM 2881 ODl ASN 377 51. .847 25. .689 31. .478 1. .00 40. .27 1SG2882
ATOM 2882 ND2 ASN 377 49. .924 25. .086 30. .430 1. .00 40. .27 1SG2883
ATOM 2883 C ASN 377 50. .798 29, .695 31, .777 1. .00 40. .27 1SG2884
ATOM 2884 O ASN 377 49. .771 30, .210 32, .214 1. .00 40. .27 1SG2885
ATOM 2885 N PHE 378 51. .735 30, .393 31, .103 1. .00 39, .44 1SG2886
ATOM 2886 CA PHE 378 51. .573 31, .787 30, .812 1, .00 39, .44 1SG2887
ATOM 2887 CB PHE 378 52. .117 32, .722 31, .914 1. .00 39, .44 1SG2888
ATOM 2888 CG PHE 378 53. .595 32, .557 32, .041 1. .00 39 .44 1SG2889
ATOM 2889 CDl PHE 378 54. ,446 33, .278 31, .235 1. .00 39, .44 1SG2890
ATOM 2890 CD2 PHE 378 54. ,135 31, .696 32, .971 1. .00 39 .44 1SG2891
ATOM 2891 CE1 PHE 378 55. .810 33 .138 31 .347 1. .00 39 .44 1SG2892
ATOM 2892 CE2 PHE 378 55. .498 31, .552 33 .087 1, .00 39 .44 1SG2893
ATOM 2893 CZ PHE 378 56, .339 32 .272 32 .273 1, .00 39 .44 1SG2894
ATOM 2894 C PHE 378 52. .310 32, .067 29, .542 1, .00 39, .44 1SG2895
ATOM 2895 O PHE 378 53. .045 31, .219 • 29 .036 1 .00 39 .44 1SG2896
ATOM 2896 N ASN 379 52. .112 33, .272 28, .973 1, .00 38, .51 1SG2897
ATOM 2897 CA ASN 379 52. .782 33, .576 27 .744 1, .00 38 .51 1SG2898
ATOM 2898 CB ASN 379 52. .311 34 .883 27 .084 1 .00 38 .51 1SG2899
ATOM 2899 CG ASN 379 50, .919 34, .650 26 .516 1, .00 38 .51 1SG2900
ATOM 2900 ODl ASN 379 50, .619 33 .572 26 .005 1 .00 38 .51 1SG2901
ATOM 2901 ND2 ASN 379 50. .044 35, .687 26 .603 1, .00 38 .51 1SG2902
ATOM 2902 C ASN 379 54, .239 33 .716 28 .040 1, .00 38 .51 1SG2903
ATOM 2903 O ASN 379 54 , .667 34, .573 28 .811 1, .00 38 .51 1SG2904
ATOM 2904 N GLU 380 55, .041 32, .866 27 .384 1, .00 44 .42 1SG2905
ATOM 2905 CA GLU 380 56, .464 32 .824 27 .527 1 .00 44 .42 1SG2906
ATOM 2906 CB GLU 380 57, .085 31, .680 26 .701 1, .00 44 .42 1SG2907
ATOM 2907 CG GLU 380 56, .476 31 .504 25 .300 1. .00 44 .42 1SG2908
ATOM 2908 CD GLU 380 57, .051 32, .490 24 .286 1, .00 44, .42 1SG2909
ATOM 2909 OEl GLU 380 57, .966 33 .278 24 .638 1, .00 44 .42 1SG2910
ATOM 2910 OE2 GLU 380 56, .572 32 .456 23 .121 1, .00 44, .42 1SG2911
ATOM 2911 C GLU 380 57. .038 34 .121 27 .063 1, .00 44 .42 1SG2912
ATOM 2912 O GLU 380 58. .095 34 .544 27 .526 1, .00 44 .42 1SG2913
ATOM 2913 N ARG 381 56. .342 34, .760 26 .109 1, .00 48, .04 1SG2914
ATOM 2914 CA ARG 381 56. .746 35 .955 25 .423 1, .00 48 .04 1SG2915
ATOM 2915 CB ARG 381 55. .766 36, .341 24 .308 1, .00 48. .04 1SG2916
ATOM 2916 CG ARG 381 55. .690 35, .281 23 .209 1, .00 48, .04 1SG2917
ATOM 2917 CD ARG 381 54, .764 35 .667 22 .058 1, .00 48 .04 1SG2918
ATOM 2918 NE ARG 381 55, .438 36, .761 21 .307 1, .00 48, .04 1SG2919
ATOM 2919 CZ ARG 381 54 .804 37 .356 20 .257 1, .00 48, .04 1SG2920
ATOM 2920 NHl ARG 381 53 , .550 36. .950 19 .900 1, .00 48, .04 1SG2921
ATOM 2921 NH2 ARG 381 55, .422 38 .359 19 .567 1, .00 48. .04 1SG2922
ATOM 2922 C ARG 381 56. .876 37. .129 26, .347 1. .00 48. .04 1SG2923
ATOM 2923 O ARG 381 57. .655 38 .039 26 .072 1. .00 48. .04 1SG2924
ATOM 2924 N GLU 382 56. .110 37 .170 27 .450 1. .00 48. .47 1SG2925
ATOM 2925 CA GLU 382 56. .124 38, .327 28 .304 1. .00 48, .47 1SG2926 ATOM 2926 CB GLU 382 55..160 38..212 29..495 1..00 48..47 1SG2927
ATOM 2927 CG GLU 382 54. .865 39, .566 30, .143 1. .00 48. .47 1SG2928
ATOM 2928 CD GLU 382 53, .885 40, .310 29, .245 1. .00 48. .47 1SG2929
ATOM 2929 OEl GLU 382 53, .122 39. .626 28, .512 1. .00 48. .47 1SG2930
ATOM 2930 OE2 GLU 382 53, .885 41. .569 29, .281 1. .00 48. .47 1SG2931
ATOM 2931 C GLU 382 57, .508 38. .569 28. .843 1. .00 48. .47 1SG2932
ATOM 2932 O GLU 382 57, .878 39, .711 29. .112 1, .00 48, .47 1SG2933
ATOM 2933 N LEU 383 58, .289 37, .492 29. .044 1. .00 47, .52 1SG2934
ATOM 2934 CA LEU 383 59, .631 37, .504 29, .568 1. .00 47, .52 1SG2935
ATOM 2935 CB LEU 383 60, .180 36. .105 29. .892 1. .00 47. .52 1SG2936
ATOM 2936 CG LEU 383 59. .521 35. .431 31. .109 1. .00 47. .52 1SG2937
ATOM 2937 CD2 LEU 383 60. .360 34, .241 31. .585 1. .00 47. .52 1SG2938
ATOM 2938 CDl LEU 383 58, .054 35, .061 30. .851 1. .00 47. .52 1SG2939
ATOM 2939 C LEU 383 60, .614 38, .134 28. .621 1, .00 47, .52 1SG2940
ATOM 2940 O LEU 383 61. .704 38. .523 29, .037 1, .00 47, .52 1SG2941
ATOM 2941 N THR 384 60. .291 38. .211 27. .319 1, .00 43 , .22 1SG2942
ATOM 2942 CA THR 384 61 .247 38, .643 26 .335 1, .00 43 .22 1SG2943
ATOM 2943 CB THR 384 60, .646 38, .772 24. .962 1, .00 43 .22 1SG2944
ATOM 2944 OGl THR 384 61, .662 39, .045 24. .008 1. .00 43, .22 1SG2945
ATOM 2945 CG2 THR 384 59, .599 39, .900 24. .969 1, .00 43, .22 1SG2946
ATOM 2946 C THR 384 61, .870 39. .964 26. .689 1, .00 43, .22 1SG2947
ATOM 2947 O THR 384 63 .086 40. .111 26 .573 1 .00 43 .22 1SG2948
ATOM 2948 N GLY 385 61 .083 40. .965 27. .124 1, .00 39 .94 1SG2949
ATOM 2949 CA GLY 385 61, .660 42, .248 27. .417 1, .00 39 .94 1SG2950
ATOM 2950 C GLY 385 62, .642 42, .124 28, .542 1, .00 39, .94 1SG2951
ATOM 2951 O GLY 385 63, .709 42, .734 28. .518 1. .00 39, .94 1SG2952
ATOM 2952 N PHE 386 62 .295 41 .344 29 .579 1 .00 39 .94 1SG2953
ATOM 2953 CA PHE 386 63, .159 41. .198 30, .714 1, .00 39 .94 1SG2954
ATOM 2954 CB PHE 386 62, .506 40. .386 31, .848 1 , .00 39, .94 1SG2955
ATOM 2955 CG PHE 386 63, .483 40, .298 32, .969 1, .00 39, .94 1SG2956
ATOM 2956 CDl PHE 386 63 , .774 41, .411 33. .724 1, .00 39, .94 1SG2957
ATOM 2957 CD2 PHE 386 64, .088 39 .103 33. .282 1. .00 39 .94 1SG2958
ATOM 2958 CE1 PHE 386 64, .670 41, .338 34. .764 1, .00 39, .94 1SG2959
ATOM 2959 CE2 PHE 386 64, .984 39, .024 34. .322 1, .00 39, .94 1SG2960
ATOM 2960 CZ PHE 386 65, .278 40, .143 35, .064 1. .00 39, .94 1SG2961
ATOM 2961 C PHE 386 64, .408 40, .494 30. .278 1. .00 39. .94 1SG2962
ATOM 2962 O PHE 386 65, .512 40 .884 30. .654 1, .00 39, .94 1SG2963
ATOM 2963 N ILE 387 64, .254 39. .437 29, .457 1. .00 40, .98 1SG2964
ATOM 2964 CA ILE 387 65. .343 38, .624 28. .994 1. .00 40, .98 1SG2965
ATOM 2965 CB ILE 387 64. .881 37, .471 28. .147 1. .00 40. .98 1SG2966
ATOM 2966 CG2 ILE 387 66. .128 36. .755 27. .600 1. .00 40. .98 1SG2967
ATOM 2967 CGI ILE 387 63. .957 36. .551 28. .963 1. .00 40, .98 1SG2968
ATOM 2968 CDl ILE 387 64. .625 35, .960 30. .203 1. .00 40, .98 1SG2969
ATOM 2969 C ILE 387 66. .272 39, .447 28. .160 1. .00 40. .98 1SG2970
ATOM 2970 O ILE 387 67. .488 39, .270 28. .216 1. .00 40. .98 1SG2971
ATOM 2971 N THR 388 65. .721 40. .352 27. .333 1. .00 43. .65 1SG2972
ATOM 2972 CA THR 388 66. .548 41. .121 26, .451 1, .00 43. .65 1SG2973
ATOM 2973 CB THR 388 65. .780 41, .965 25, .474 1. .00 43. .65 1SG2974
ATOM 2974 OGl THR 388 66. .655 42, .452 24. .466 1. .00 43. .65 1SG2975
ATOM 2975 CG2 THR 388 65. .139 43. .146 26. .219 1. .00 43. .65 1SG2976
ATOM 2976 C THR 388 67. .452 42. .025 27. .222 1. .00 43. ,65 1SG2977
ATOM 2977 O THR 388 68. .584 42. .252 26. .806 1. .00 43. .65 1SG2978
ATOM 2978 N SER 389 66. .963 42. .627 28. .322 1. .00 45. .70 1SG2979
ATOM 2979 CA SER 389 67. .768 43. .528 29. .099 1. ,00 45. .70 1SG2980
ATOM 2980 CB SER 389 66. ,925 44. .397 30. ,048 1. ,00 45. ,70 1SG2981
ATOM 2981 OG SER 389 66. ,058 45. ,235 29. ,298 1. ,00 45. ,70 1SG2982
ATOM 2982 C SER 389 68. .782 42. .813 29. .944 1. ,00 45. .70 1SG2983 ATOM 2983 O SER 389 69..968 43..142 29,.923 1..00 45,.70 1SG2984
ATOM 2984 N TYR 390 68. .335 41. .802 30, .713 1. .00 45. .79 1SG2985
ATOM 2985 CA TYR 390 69. .171 41. .199 31, .709 1. .00 45. .79 1SG2986
ATOM 2986 CB TYR 390 68, .428 40, .161 32, ,563 1. .00 45. .79 1SG2987
ATOM 2987 CG TYR 390 69 .044 40, .289 33, .911 1. .00 45. .79 1SG2988
ATOM 2988 CDl TYR 390 70 .207 39, .647 34, .266 1. .00 45. .79 1SG2989
ATOM 2989 CD2 TYR 390 68 .424 41, .106 34, .828 1. .00 45. .79 1SG2990
ATOM 2990 CE1 TYR 390 70, .725 39. .826 35, .529 1. .00 45, .79 1SG2991
ATOM 2991 CE2 TYR 390 68, .938 41. .286 36, ,087 1. .00 45, .79 1SG2992
ATOM 2992 CZ TYR 390 70 .096 40 .643 36. .440 1, .00 45, .79 1SG2993
ATOM 2993 OH TYR 390 70, .629 40. .829 37, .733 1, .00 45, .79 1SG2994
ATOM 2994 C TYR 390 70, .342 40. .533 31. .054 1. .00 45, .79 1SG2995
ATOM 2995 O TYR 390 71, .472 40, .655 31. .524 1. .00 45. .79 1SG2996
ATOM 2996 N LEU 391 70 .102 39 .817 29 .938 1, .00 44. .94 1SG2997
ATOM 2997 CA LEU 391 71 .142 39, .074 29. .279 1, .00 44, .94 1SG2998
ATOM 2998 CB LEU 391 70. .649 38, .471 27. .937 1, .00 44, .94 1SG2999
ATOM 2999 CG LEU 391 71. .568 37, .487 27. .154 1. .00 44, .94 1SG3000
ATOM 3000 CD2 LEU 391 73, .064 37, .841 27, .120 1. .00 44, .94 1SG3001
ATOM 3001 CDl LEU 391 71 .009 37 .280 25 .736 1, .00 44 .94 1SG3002
ATOM 3002 C LEU 391 72, .242 40, .011 28, .886 1. .00 44, .94 1SG3003
ATOM 3003 O LEU 391 73, .391 39, .839 29, .287 1, .00 44, .94 1SG3004
ATOM 3004 N GLU 392 71, .914 41, .034 28, .079 1. .00 44, .51 1SG3005
ATOM 3005 CA GLU 392 72 .930 41 .882 27 .531 1. .00 44 .51 1SG3006
ATOM 3006 CB GLU 392 72 .367 42, .883 26 .506 1, .00 44 .51 1SG3007
ATOM 3007 CG GLU 392 71, .340 43, .852 27, .096 1. .00 44, .51 1SG3008
ATOM 3008 CD GLU 392 70, .868 44, .778 25, .983 1. .00 44, .51 1SG3009
ATOM 3009 OEl GLU 392 71, .219 44, .514 24 , .803 1, .00 44, .51 1SG3010
ATOM 3010 OE2 GLU 392 70 .144 45 .760 26 .299 1, .00 44 .51 1SG3011
ATOM 3011 C GLU 392 73 .598 42, .670 28, .605 1, .00 44 .51 1SG3012
ATOM 3012 O GLU 392 74. .818 42, .819 28, .603 1, .00 44, .51 1SG3013
ATOM 3013 N GLU 393 72, .819 43 , .252 29, .531 1, .00 44, .90 1SG3014
ATOM 3014 CA GLU 393 73 .468 44, .053 30, .521 1 .00 44 .90 1SG3015
ATOM 3015 CB GLU 393 72 .474 44, .913 31, .320 1, .00 44, .90 1SG3016
ATOM 3016 CG GLU 393 71, .803 46, .001 30, .479 1. .00 44, .90 1SG3017
ATOM 3017 CD GLU 393 70, .848 46, .770 31. .381 1, .00 44, .90 1SG3018
ATOM 3018 OEl GLU 393 70. .261 46. .135 32. .297 1. .00 44, .90 1SG3019
ATOM 3019 OE2 GLU 393 70 .695 48. .002 31, .166 1, .00 44, .90 1SG3020
ATOM 3020 C GLU 393 74. .222 43 , .215 31, .506 1, .00 44, .90 1SG3021
ATOM 3021 O GLU 393 75. .412 43. .430 31. .722 1. .00 44, .90 1SG3022
ATOM 3022 N ALA 394 73. .523 42. .280 32. .183 1. .00 45. .63 1SG3023
ATOM 3023 CA ALA 394 74 , .145 41, ,479 33 , .203 1. .00 45. .63 1SG3024
ATOM 3024 CB ALA 394 73. .119 40, .865 34. ,164 1. .00 45, .63 1SG3025
ATOM 3025 C ALA 394 75, .019 40. ,347 32. .734 1. .00 45. .63 1SG3026
ATOM 3026 O ALA 394 76. .165 40. ,234 33. .164 1. .00 45. .63 1SG3027
ATOM 3027 N TYR 395 74. .475 39. .453 31. .875 1. ,00 46. .88 1SG3028
ATOM 3028 CA TYR 395 75, .160 38, ,233 31. .523 1. .00 46. .88 1SG3029
ATOM 3029 CB TYR 395 74 , .227 37. ,149 30. .957 1. .00 46. .88 1SG3030
ATOM 3030 CG TYR 395 75. .094 35. ,975 30. .647 1. .00 46. .88 1SG3031
ATOM 3031 CDl TYR 395 75. .443 35. .095 31. ,646 1. .00 46. .88 1SG3032
ATOM 3032 CD2 TYR 395 75. .578 35. .762 29. ,379 1. .00 46. .88 1SG3033
ATOM 3033 CE1 TYR 395 76. .247 34. .011 31. .383 1. .00 46. .88 1SG3034
ATOM 3034 CE2 TYR 395 76. .382 34. ,680 29. .107 1. ,00 46. .88 1SG3035
ATOM 3035 CZ TYR 395 76. .716 33. ,802 30. ,109 1. ,00 46. ,88 1SG3036
ATOM 3036 OH TYR 395 77. ,541 32. ,691 29. .834 1. ,00 46. 88 1SG3037
ATOM 3037 C TYR 395 76. .302 38. .365 30. .560 1. ,00 46. ,88 1SG3038
ATOM 3038 O TYR 395 77. .398 37. .875 30. .822 1. ,00 46. ,88 1SG3039
ATOM 3039 N ILE 396 76. .088 39. .032 29. ,414 1. 00 46. 30 1SG3040 ATOM 3040 CA ILE 396 77,.101 39..044 28,.399 1..00 46..30 1SG3041
ATOM 3041 CB ILE 396 76, .649 39. .542 27. .041 1. .00 46. .30 1SG3042
ATOM 3042 CG2 ILE 396 76, .224 41. .015 27. .088 1. .00 46. .30 1SG3043
ATOM 3043 CGI ILE 396 77. .735 39. .237 25. .996 1. .00 46. .30 1SG3044
ATOM 3044 CDl ILE 396 77. .254 39. .402 24 , .556 1. .00 46. .30 1SG3045
ATOM 3045 C ILE 396 78, .358 39. .722 28. .865 1. .00 46. .30 1SG3046
ATOM 3046 O ILE 396 79, .435 39. .289 28. .459 1, .00 46. .30 1SG3047
ATOM 3047 N PRO 397 78, .348 40. .750 29. .673 1, .00 43. .97 1SG3048
ATOM 3048 CA PRO 397 79. .591 41. .357 30. .043 1. .00 43. .97 1SG3049
ATOM 3049 CD PRO 397 77, .225 41. .660 29. .852 1. .00 43. .97 1SG3050
ATOM 3050 CB PRO 397 79, .228 42. .604 30. .845 1, .00 43. .97 1SG3051
ATOM 3051 CG PRO 397 77, .843 42. .994 30. .301 1. .00 43. .97 1SG3052
ATOM 3052 C PRO 397 80. .517 40. .423 30. .756 1. .00 43. .97 1SG3053
ATOM 3053 O PRO 397 81 .727 40, .551 30. .575 1. .00 43, .97 1SG3054
ATOM 3054 N VAL 398 79, .995 39, .495 31. .581 1. .00 42, .01 1SG3055
ATOM 3055 CA VAL 398 80, .863 38. .611 32. .302 1, .00 42, .01 1SG3056
ATOM 3056 CB VAL 398 80. .150 37. .757 33. .319 1. .00 42, .01 1SG3057
ATOM 3057 CGI VAL 398 79, .484 38. .685 34. ,347 1. .00 42. .01 1SG3058
ATOM 3058 CG2 VAL 398 79 .177 36, .801 32. .610 1 .00 42. .01 1SG3059
ATOM 3059 C VAL 398 81 .551 37, .699 31, .337 1 .00 42. .01 1SG3060
ATOM 3060 O VAL 398 82, .745 37. .438 31, .463 1, .00 42, .01 1SG3061
ATOM 3061 N VAL 399 80, .813 37. .176 30, .341 1, .00 39, .44 1SG3062
ATOM 3062 CA VAL 399 81 .425 36, .252 29, .435 1 .00 39, .44 1SG3063
ATOM 3063 CB VAL 399 80 .482 35, .638 28, .436 1 .00 39, .44 1SG3064
ATOM 3064 CGI VAL 399 79, .446 34, .796 29. .192 1, .00 39, .44 1SG3065
ATOM 3065 CG2 VAL 399 79, .875 36. .739 27. .554 1, .00 39, .44 1SG3066
ATOM 3066 C VAL 399 82, .500 36. .937 28. .652 1, .00 39, .44 1SG3067
ATOM 3067 O VAL 399 83 .592 36. .398 28. .496 1 .00 39, .44 1SG3068
ATOM 3068 N ASN 400 82, .238 38. .165 28. .168 1 .00 37 .78 1SG3069
ATOM 3069 CA ASN 400 83, .175 38. .843 27. .317 1, .00 37, .78 1SG3070
ATOM 3070 CB ASN 400 82, .738 40. .265 26. .918 1, .00 37, .78 1SG3071
ATOM 3071 CG ASN 400 81 .707 40. .175 25. .804 1 .00 37 .78 1SG3072
ATOM 3072 ODl ASN 400 81, .612 39, .167 25, .106 1, .00 37, .78 1SG3073
ATOM 3073 ND2 ASN 400 80, .927 41, ,273 25, .617 1. .00 37, .78 1SG3074
ATOM 3074 C ASN 400 84, .481 38. ,991 28. .015 1, .00 37, .78 1SG3075
ATOM 3075 O ASN 400 85. .529 38. ,908 27. .378 1, .00 37. .78 1SG3076
ATOM 3076 N ASP 401 84. .473 39. .231 29, .337 1, .00 38, .05 1SG3077
ATOM 3077 CA ASP 401 85. .731 39. ,438 29, .988 1, .00 38, .05 1SG3078
ATOM 3078 CB ASP 401 85. .618 39. .937 31. .449 1, .00 38, .05 1SG3079
ATOM 3079 CG ASP 401 84. .838 38. .974 32. .333 1, .00 38. .05 1SG3080
ATOM 3080 ODl ASP 401 85. .148 37, .754 32. .333 1, .00 38. .05 1SG3081
ATOM 3081 OD2 ASP 401 83. .922 39, .464 33. .047 1, .00 38. .05 1SG3082
ATOM 3082 C ASP 401 86. .594 38. .211 29. .885 1, .00 38. .05 1SG3083
ATOM 3083 O ASP 401 87. .806 38. .330 29. .717 1. .00 38. .05 1SG3084
ATOM 3084 N VAL 402 86. .012 37. ,000 29. .986 1. .00 37. ,52 1SG3085
ATOM 3085 CA VAL 402 86, .781 35. .788 29. .882 1, .00 37. .52 1SG3086
ATOM 3086 CB VAL 402 85, .947 34. ,568 30. .143 1, .00 37. .52 1SG3087
ATOM 3087 CGI VAL 402 86. .819 33. .319 29. .936 1. .00 37. .52 1SG3088
ATOM 3088 CG2 VAL 402 85. .335 34. .684 31. .549 1. .00 37. .52 1SG3089
ATOM 3089 C VAL 402 87. .324 35. .665 28, .489 1. .00 37. .52 1SG3090
ATOM 3090 O VAL 402 88. .497 35. .359 28, .285 1. .00 37. .52 1SG3091
ATOM 3091 N LEU 403 86. .475 35. .914 27. .479 1. .00 37. .63 1SG3092
ATOM 3092 CA LEU 403 86. .887 35. ,801 26. .108 1. .00 37. .63 1SG3093
ATOM 3093 CB LEU 403 85. ,751 36. ,088 25. .103 1. ,00 37. .63 1SG3094
ATOM 3094 CG LEU 403 84. .653 35. .006 24. .998 1. .00 37. .63 1SG3095
ATOM 3095 CD2 LEU 403 83. .927 34. ,768 26. .327 1. .00 37. .63 1SG3096
ATOM 3096 CDl LEU 403 85. .207 33. ,707 24 , .403 1. .00 37. ,63 1SG3097 ATOM 3097 C LEU 403 87..959 36..810 25..856 1..00 37..63 1SG3098
ATOM 3098 O LEU 403 88. .908 36. .558 25. .115 1. .00 37. .63 1SG3099
ATOM 3099 N GLN 404 87. .810 37. .995 26. ,466 1. ,00 38. .42 1SG3100
ATOM 3100 CA GLN 404 88. .729 39. .081 26. .312 1. ,00 38. .42 1SG3101
ATOM 3101 CB GLN 404 88. .264 40. .342 27. .060 1. .00 38, .42 1SG3102
ATOM 3102 CG GLN 404 89. .216 41. .530 26. .919 1. .00 38. .42 1SG3103
ATOM 3103 CD GLN 404 89. .070 42, .072 25. .505 1. .00 38, .42 1SG3104
ATOM 3104 OEl GLN 404 90. .057 42. .410 24. .854 1. ,00 38. .42 1SG3105
ATOM 3105 NE2 GLN 404 87. .804 42. .165 25. .017 1. ,00 38. .42 1SG3106
ATOM 3106 C GLN 404 90. .053 38. .685 26. .887 1. .00 38. .42 1SG3107
ATOM 3107 O GLN 404 91. .092 39. .059 26. .346 1. .00 38, .42 1SG3108
ATOM 3108 N VAL 405 90. .067 37. .934 28. .011 1. .00 38. .65 1SG3109
ATOM 3109 CA VAL 405 91, .345 37. .585 28. .563 1. .00 38, .65 1SG3110
ATOM 3110 CB VAL 405 91, .301 36, .817 29. .864 1. .00 38, .65 1SG3111
ATOM 3111 CGI VAL 405 90. .877 35, .360 29, .626 1. .00 38 .65 1SG3112
ATOM 3112 CG2 VAL 405 92. .681 36. .942 30. .531 1. .00 38, .65 1SG3113
ATOM 3113 C VAL 405 92. .037 36. .769 27. .525 1. .00 38, .65 1SG3114
ATOM 3114 O VAL 405 93. .224 36. .958 27. .262 1. .00 38, .65 1SG3115
ATOM 3115 N GLY 406 91. .292 35. .853 26. .881 1. .00 42 .56 1SG3116
ATOM 3116 CA GLY 406 91. .855 35. .115 25. .792 1. .00 42 .56 1SG3117
ATOM 3117 C GLY 406 92, .465 33. .838 26. .267 1. .00 42 .56 1SG3118
ATOM 3118 O GLY 406 92 .410 33. .496 27, .448 1. .00 42 .56 1SG3119
ATOM 3119 N LEU 407 93, .046 33. .095 25. .300 1. .00 49, .74 1SG3120
ATOM 3120 CA LEU 407 93, .671 31, .825 25. .524 1. .00 49, .74 1SG3121
ATOM 3121 CB LEU 407 92. .939 30, .698 24. .767 1. .00 49 .74 1SG3122
ATOM 3122 CG LEU 407 93. .299 29, .255 25. .172 1. .00 49 .74 1SG3123
ATOM 3123 CD2 LEU 407 92, .903 28, .982 26. .629 1, .00 49 .74 1SG3124
ATOM 3124 CDl LEU 407 94, .758 28 .898 24, .868 1. .00 49 .74 1SG3125
ATOM 3125 C LEU 407 95, .061 31 .954 24, .974 1. .00 49 .74 1SG3126
ATOM 3126 O LEU 407 95, .274 32 .621 23, .962 1. .00 49 .74 1SG3127
ATOM 3127 N PRO 408 96, .023 31, .350 25. .615 1. .00 55 .39 1SG3128
ATOM 3128 CA PRO 408 97, .379 31, .509 25. .157 1. .00 55 .39 1SG3129
ATOM 3129 CD PRO 408 95, .953 31, .197 27. .059 1, .00 55 .39 1SG3130
ATOM 3130 CB PRO 408 98, .266 31, .088 26. .325 1. .00 55 .39 1SG3131
ATOM 3131 CG PRO 408 97. .396 31, .367 27. .563 1. .00 55 .39 1SG3132
ATOM 3132 C PRO 408 97, .650 30, .779 23. .880 1, .00 55 .39 1SG3133
ATOM 3133 O PRO 408 97, .080 29 .711 23. .673 1. .00 55 .39 1SG3134
ATOM 3134 N LEU 409 98. .517 31, .321 23. .002 1. .00 61, .21 1SG3135
ATOM 3135 CA LEU 409 98. .788 30, .595 21. .797 1. .00 61, .21 1SG3136
ATOM 3136 CB LEU 409 98, .684 31, .408 20. .500 1, .00 61 .21 1SG3137
ATOM 3137 CG LEU 409 97, .211 31, .711 20. .168 1. .00 61 .21 1SG3138
ATOM 3138 CD2 LEU 409 96, .336 30, .458 20. .346 1. .00 61 .21 1SG3139
ATOM 3139 CDl LEU 409 97, .055 32, .344 18. .782 1, .00 61 .21 1ΞG3140
ATOM 3140 C LEU 409 100, .123 29, .941 21. .915 1. .00 61 .21 1SG3141
ATOM 3141 O LEU 409 100, .956 30, .334 22. .730 1. .00 61 .21 1SG3142
ATOM 3142 N PRO 410 100. .317 28, .877 21. .184 1. .00 61, .67 1SG3143
ATOM 3143 CA PRO 410 101. .557 28, .161 21. .268 1. .00 61, .67 1SG3144
ATOM 3144 CD PRO 410 99. .249 28, .081 20. .613 1. .00 61, .67 1SG3145
ATOM 3145 CB PRO 410 101. .315 26, .809 20. .593 1, .00 61, .67 1SG3146
ATOM 3146 CG PRO 410 99. .996 26, .999 19. .815 1. .00 61, .67 1SG3147
ATOM 3147 C PRO 410 102. .679 28, .949 20. .694 1. .00 61 .67 1SG3148
ATOM 3148 O PRO 410 103. .010 28, .738 19. .529 1. .00 61 .67 1SG3149
ATOM 3149 N ASP 411 103. .334 29, .793 21. .508 1. .00 57, .00 1SG3150
ATOM 3150 CA ASP 411 104. .403 30, .583 20. .982 1. .00 57, .00 1SG3151
ATOM 3151 CB ASP 411 104. .123 32, .093 21. .050 1. .00 57, .00 1SG3152
ATOM 3152 CG ASP 411 102. .965 32 , .387 20. .107 1. .00 57, .00 1SG3153
ATOM 3153 ODl ASP 411 102. .681 31, .524 19. .233 1. .00 57, .00 1SG3154 ATOM 3154 OD2 ASP 411 102,.347 33.475 20.250 1,.00 57.00 1SG3155
ATOM 3155 C ASP 411 105, .621 30 .314 21, .800 1, .00 57, .00 1SG3156
ATOM 3156 O ASP 411 105. .545 30. .128 23, .013 1. .00 57. .00 1SG3157
ATOM 3157 N PHE 412 106 .788 30 .295 21, .131 1, .00 54 .32 1SG3158
ATOM 3158 CA PHE 412 108. .053 30 .082 21, .783 1, .00 54 .32 1SG3159
ATOM 3159 CB PHE 412 109. .267 30. .142 20, .834 1. .00 54. .32 1SG3160
ATOM 3160 CG PHE 412 109 .266 29 .059 19, .811 1, .00 54 .32 1SG3161
ATOM 3161 CDl PHE 412 108. .546 29 .202 18, .647 1, .00 54, .32 1SG3162
ATOM 3162 CD2 PHE 412 109 .996 27 .908 20 .005 1 .00 54 .32 1SG3163
ATOM 3163 CE1 PHE 412 108 .548 28 .211 17, .695 1, .00 54 .32 1SG3164
ATOM 3164 CE2 PHE 412 110. .004 26. .914 19. .055 1. .00 54. .32 1SG3165
ATOM 3165 CZ PHE 412 109 .279 27 .066 17. .897 1, .00 54 .32 1SG3166
ATOM 3166 C PHE 412 108, .243 31 .286 22. .650 1, .00 54 .32 1SG3167
ATOM 3167 O PHE 412 107, .486 32, .248 22. .555 1. .00 54, .32 1SG3168
ATOM 3168 N LEU 413 109 .246 31 .253 23. .547 1. .00 49 .59 1SG3169
ATOM 3169 CA LEU 413 109, .497 32 .369 24, .410 1. .00 49 .59 1SG3170
ATOM 3170 CB LEU 413 110 .399 32 .033 25, .609 1, .00 49 .59 1SG3171
ATOM 3171 CG LEU 413 109 .778 31 .004 26, .572 1, .00 49 .59 1SG3172
ATOM 3172 CD2 LEU 413 108, .346 31, .400 26, .964 1. .00 49, .59 1SG3173
ATOM 3173 CDl LEU 413 110 .686 30 .758 27, .788 1. .00 49 .59 1SG3174
ATOM 3174 C LEU 413 110 .173 33 .450 23, .622 1. .00 49 .59 1SG3175
ATOM 3175 O LEU 413 110, .775 33, .194 22. .580 1. .00 49 .59 1SG3176
ATOM 3176 N ALA 414 110 .067 34 .701 24. .120 1. .00 46 .44 1SG3177
ATOM 3177 CA ALA 414 110, .686 35 .858 23, .536 1, .00 46 .44 1SG3178
ATOM 3178 CB ALA 414 112 .224 35 .780 23, .532 1, .00 46 .44 1SG3179
ATOM 3179 C ALA 414 110 .234 36 .074 22, .127 1, .00 46 .44 1SG3180
ATOM 3180 O ALA 414 111, .018 36 .507 21, .283 1, .00 46 .44 1SG3181
ATOM 3181 N MET 415 108 .951 35 .800 21, .828 1, .00 45 .77 1SG3182
ATOM 3182 CA MET 415 108, .476 36 .053 20. .497 1, .00 45 .77 1SG3183
ATOM 3183 CB MET 415 108, .123 34, .780 19. .710 1, .00 45 .77 1SG3184
ATOM 3184 CG MET 415 109 .334 33 .899 19. .402 1, .00 45 .77 1SG3185
ATOM 3185 SD MET 415 110, .560 34, .668 18. .302 1, .00 45 .77 1SG3186
ATOM 3186 CE MET 415 111 .599 33 .185 18. .161 1, .00 45 .77 1SG3187
ATOM 3187 C MET 415 107, .218 36 .846 20. .626 1, .00 45 .77 1SG3188
ATOM 3188 o MET 415 106. .477 36. .695 21. .595 1. .00 45 .77 1SG3189
ATOM 3189 N ASN 416 106 .961 37 .736 19, .648 1, .00 44 .50 1SG3190
ATOM 3190 CA ASN 416 105. .773 38 .538 19. .660 1, .00 44 .50 1SG3191
ATOM 3191 CB ASN 416 106. .067 40. .026 19. .932 1. .00 44, .50 1SG3192
ATOM 3192 CG ASN 416 104, .780 40. .764 20. .280 1. .00 44, .50 1ΞG3193
ATOM 3193 ODl ASN 416 103 , .738 40, .595 19. .649 1. .00 44, .50 1SG3194
ATOM 3194 ND2 ASN 416 104, .856 41 .624 21. .330 1, .00 44 .50 1SG3195
ATOM 3195 C ASN 416 105, .201 38, .433 18. .283 1. .00 44, .50 1SG3196
ATOM 3196 O ASN 416 105. .943 38. .329 17. .308 1. .00 44 , .50 1SG3197
ATOM 3197 N TYR 417 103 , .860 38. .447 18. .158 1. .00 45, .64 1SG3198
ATOM 3198 CA TYR 417 103. .304 38, .336 16. ,843 1. .00 45. .64 1SG3199
ATOM 3199 CB TYR 417 102. .341 37. .150 16. ,671 1. .00 45. .64 1SG3200
ATOM 3200 CG TYR 417 103. .206 35. .941 16. .751 1. .00 45. .64 1SG3201
ATOM 3201 CDl TYR 417 103. .514 35. .375 17. ,966 1. .00 45. .64 1SG3202
ATOM 3202 CD2 TYR 417 103. .725 35. .384 15. .605 1. .00 45, .64 1SG3203
ATOM 3203 CE1 TYR 417 104. .320 34. .263 18. ,035 1. ,00 45. .64 1SG3204
ATOM 3204 CE2 TYR 417 104. .531 34. .273 15. ,667 1. ,00 45. .64 1SG3205
ATOM 3205 CZ TYR 417 104. .829 33, .710 16. ,885 1. .00 45. .64 1SG3206
ATOM 3206 OH TYR 417 105. .657 32. .570 16. ,953 1. .00 45. .64 1SG3207
ATOM 3207 C TYR 417 102. ,589 39. .605 16. ,517 1. ,00 45. ,64 1SG3208
ATOM 3208 O TYR 417 101. ,885 40. .174 17. ,350 1. ,00 45. .64 1SG3209
ATOM 3209 N ASN 418 102. ,796 40. ,095 15. 278 1. 00 47. .25 1SG3210
ATOM 3210 CA ASN 418 102. .201 41, .331 14. ,862 1. ,00 47. .25 1SG3211 > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > >
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H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H to to to to to to to to m m to to to to m to to to to to to to to to to to to to to to to to to w to to to m to to to to to to to m to to m ci- to to to to to to to Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ Ω Ω Ώ Ώ Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H 4* ι^ 4* 4* 4* 4* 4* 4* 4* 4* Ul Ul UJ Ul _J UJ Ul UJ UJ Ul tO tO tO tO t t0 10 tO t t H H H H H H H O O O O O O O O O O VO VO VO VO VD VD VD vo oo si en ui 4* uJ tO H O VD OO si en ui 4* ui tO H O vo cD si oi ui 4* ui to H O VD CD 01 Ul 4* l O ID 00 sl Ol Ul 4* Ul to H o vo co si en ui it* UJ
ATOM 149 OEl GLN 19 120..075 39..028 7..555 1..00 33,.77 ISG 150
ATOM 150 NE2 GLN 19 120. .889 40, .905 8. .549 1. .00 33, .77 ISG 151
ATOM 151 C GLN 19 119. .332 37, .183 11, .081 1. .00 33, .77 ISG 152
ATOM 152 O GLN 19 120. .458 37, .480 11. .477 1. .00 33, .77 ISG 153
ATOM 153 N ALA 20 118. .339 36. .854 11. .925 1. .00 32, .50 ISG 154
ATOM 154 CA ALA 20 118. .571 36. .883 13. .335 1. .00 32, .50 ISG 155
ATOM 155 CB ALA 20 117. .313 36, .547 14 , .154 1. .00 32, .50 ISG 156
ATOM 156 C ALA 20 119. .606 35, .857 13. .658 1. .00 32, .50 ISG 157
ATOM 157 O ALA 20 120. .519 36. .103 14, .444 1. .00 32, .50 ISG 158
ATOM 158 N GLY 21 119. .491 34. .672 13. .035 1. .00 34, .77 ISG 159
ATOM 159 CA GLY 21 120. .371 33, .584 13. .339 1. .00 34, .77 ISG 160
ATOM 160 C GLY 21 121 .789 33 .891 12 .970 1. .00 34 .77 ISG 161
ATOM 161 O GLY 21 122 .702 33 .628 13 .749 1. .00 34, .77 ISG 162
ATOM 162 N MET 22 122 .017 34 .468 11, .777 1. .00 40 .05 ISG 163
ATOM 163 CA MET 22 123 .360 34 .675 11 .314 1, .00 40 .05 ISG 164
ATOM 164 CB MET 22 123 .419 35 .241 9 .880 1. .00 40 .05 ISG 165
ATOM 165 CG MET 22 122 .976 36 .700 9 .727 1. .00 40, .05 ISG 166
ATOM 166 SD MET 22 124 .210 37 .939 10 .230 1, .00 40 .05 ISG 167
ATOM 167 CE MET 22 123 .162 39 .370 9 .840 1, .00 40 .05 ISG 168
ATOM 168 C MET 22 124 .039 35 .622 12 .245 1. .00 40 .05 ISG 169
ATOM 169 O MET 22 125 .212 35 .455 12 .577 1, .00 40 .05 ISG 170
ATOM 170 N LYS 23 123 .308 36, .645 12. .715 1. .00 42 .30 ISG 171
ATOM 171 CA LYS 23 123 .933 37, .598 13. .578 1. .00 42 .30 ISG 172
ATOM 172 CB LYS 23 122 .965 38 .695 14, .051 1. .00 42 .30 ISG 173
ATOM 173 CG LYS 23 122 .469 39, .598 12, .920 1. .00 42 .30 ISG 174
ATOM 174 CD LYS 23 121 .276 40, .472 13, .312 1. .00 42 .30 ISG 175
ATOM 175 CE LYS 23 120 .779 41, .375 12 .182 1. .00 42 .30 ISG 176
ATOM 176 NZ LYS 23 119 .628 42. .181 12, .646 1, .00 42 .30 ISG 177
ATOM 177 C LYS 23 124 .407 36. .865 14, .789 1. .00 42 .30 ISG 178
ATOM 178 O LYS 23 125, .542 37. .035 15, .230 1. .00 42 .30 ISG 179
ATOM 179 N MET 24 123 .543 36. .001 15, .344 1, .00 48, .92 ISG 180
ATOM 180 CA MET 24 123 .905 35. .260 16, .514 1. .00 48 .92 ISG 181
ATOM 181 CB MET 24 122, .742 34. .461 17, .129 1. .00 48, .92 ISG 182
ATOM 182 CG MET 24 121, .837 35. .285 18, .052 1. .00 48. .92 ISG 183
ATOM 183 SD MET 24 120, ,837 36, .571 17, .250 1. .00 48, .92 ISG 184
ATOM 184 CE MET 24 122, .196 37, .765 17, .097 1. .00 48, .92 ISG 185
ATOM 185 C MET 24 125, .011 34, .303 16 , .196 1. .00 48, .92 ISG 186
ATOM 186 O MET 24 125, .864 34, .036 17. .039 1. .00 48, .92 ISG 187
ATOM 187 N ILE 25 125, .010 33, .729 14. .980 1. .00 53, .35 ISG 188
ATOM 188 CA ILE 25 125, .994 32, .744 14. .639 1. .00 53. .35 ISG 189
ATOM 189 CB ILE 25 125, .698 31. .965 13. .374 1. ,00 53, .35 ISG 190
ATOM 190 CG2 ILE 25 124, .341 31. .276 13. .590 1. ,00 53. .35 ISG 191
ATOM 191 CGI ILE 25 125, .732 32. .818 12. .095 1. .00 53. .35 ISG 192
ATOM 192 CDl ILE 25 127, .134 33. .202 11. .622 1. .00 53. .35 ISG 193
ATOM 193 C ILE 25 127, .362 33. .343 14. .557 1. .00 53. .35 ISG 194
ATOM 194 O ILE 25 128. .343 32. .710 14. .942 1. .00 53. .35 ISG 195
ATOM 195 N GLU 26 127. .470 34. .586 14. .061 1. ,00 56. .17 ISG 196
ATOM 196 CA GLU 26 128. .765 35. .156 13. .830 1. ,00 56. .17 ISG 197
ATOM 197 CB GLU 26 128. .702 36. .596 13. .289 1. .00 56. .17 ISG 198
ATOM 198 CG GLU 26 128. .046 37. .591 14. ,248 1. .00 56. .17 ISG 199
ATOM 199 CD GLU 26 128. .055 38. .961 13. ,584 1. 00 56. .17 ISG 200
ATOM 200 OEl GLU 26 128. .564 39. .058 12. ,435 1. 00 56. .17 ISG 201
ATOM 201 OE2 GLU 26 127. .554 39. .927 14. ,218 1. 00 56. ,17 ISG 202
ATOM 202 C GLU 26 129. .563 35. .184 15. .100 1. 00 56. ,17 ISG 203
ATOM 203 O GLU 26 130. ,752 34. 866 15. .091 1. 00 56. ,17 ISG 204
ATOM 204 N GLN 27 128. .935 35. .539 16. .235 1. 00 61. .45 ISG 205
ATOM 205 CA GLN 27 129, .668 35. .672 17. .463 1. ,00 61. .45 ISG 206 ATOM 206 CB GLN 27 128,.780 36.121 18.638 1..00 61,.45 ISG 207
ATOM 207 CG GLN 27 129, .539 36. .273 19. .958 1. .00 61. .45 ISG 208
ATOM 208 CD GLN 27 130. .370 37, .546 19, .890 1. .00 61. .45 ISG 209
ATOM 209 OEl GLN 27 130. .421 36 .492 20 .522 1. .00 61. .45 ISG 210
ATOM 210 NE2 GLN 27 129, .571 38, .122 18, .952 1. .00 61. .45 ISG 211
ATOM 211 C GLN 27 130, .286 34. .363 17, .845 1. .00 61. .45 ISG 212
ATOM 212 O GLN 27 131, .451 34 .314 18 .238 1. .00 61, .45 ISG 213
ATOM 213 N MET 28 129. .528 33. .260 17, .723 1. .00 62, .51 ISG 214
ATOM 214 CA MET 28 130 .021 31 .974 18 .122 1, .00 62, .51 ISG 215
ATOM 215 CB MET 28 128, .961 30, .865 18 .022 1. .00 62, .51 ISG 216
ATOM 216 CG MET 28 129, .372 29, .573 18, .732 1. .00 62. .51 ISG 217
ATOM 217 SD MET 28 129, .398 29 .685 20 .546 1. .00 62. .51 ISG 218
ATOM 218 CE MET 28 129, .923 27, .965 20 .803 1. .00 62, .51 ISG 219
ATOM 219 C MET 28 131. .159 31, .612 17, .236 1. .00 62 , .51 ISG 220
ATOM 220 O MET 28 132, .132 30, .994 17 .669 1. .00 62, .51 ISG 221
ATOM 221 N LEU 29 131, .058 31, .988 15, .953 1. .00 65. .49 ISG 222
ATOM 222 CA LEU 29 132 .100 31 .652 15 .046 1. .00 65 .49 ISG 223
ATOM 223 CB LEU 29 131, .803 32, .039 13 .587 1. .00 65, .49 ISG 224
ATOM 224 CG LEU 29 130. .920 31, .025 12, .834 1. .00 65, .49 ISG 225
ATOM 225 CD2 LEU 29 129. .626 30 .703 13 .591 1. .00 65 .49 ISG 226
ATOM 226 CDl LEU 29 131, .717 29 .756 12 .498 1. .00 65, .49 ISG 227
ATOM 227 C LEU 29 133, .373 32, .309 15, .459 1. .00 65, .49 ISG 228
ATOM 228 O LEU 29 134, .414 31 .666 15 .435 1. .00 65 .49 ISG 229
ATOM 229 N LYS 30 133, .314 33, .576 15 .910 1. .00 64, .71 ISG 230
ATOM 230 CA LYS 30 134 .470 34 .365 16 .258 1. .00 64 .71 ISG 231
ATOM 231 CB LYS 30 134, .064 35, .745 16 .801 1. .00 64, .71 ISG 232
ATOM 232 CG LYS 30 135, .226 36, .615 17, .283 1. .00 64, .71 ISG 233
ATOM 233 CD LYS 30 136, .103 37 .199 16 .177 1. .00 64 .71 ISG 234
ATOM 234 CE LYS 30 137, .208 38, .101 16 .730 1. .00 64, .71 ISG 235
ATOM 235 NZ LYS 30 137, .856 38, .846 15, .632 1. .00 64, .71 ISG 236
ATOM 236 C LYS 30 135, .262 33 .684 17 .338 1. .00 64 .71 ISG 237
ATOM 237 O LYS 30 136, .475 33, .863 17, .429 1. .00 64, .71 ISG 238
ATOM 238 N GLU 31 134, .577 32 .917 18 .202 1, .00 64 .10 ISG 239
ATOM 239 CA GLU 31 135, .112 32, .255 19, .364 1. .00 64, .10 ISG 240
ATOM 240 CB GLU 31 134. .008 31, .673 20, .264 1. .00 64. .10 ISG 241
ATOM 241 CG GLU 31 133, .125 32 .740 20 .916 1. .00 64. .10 ISG 242
ATOM 242 CD GLU 31 132, .084 32, .031 21, .770 1. .00 64, .10 ISG 243
ATOM 243 OEl GLU 31 132. .108 30, .772 21, .808 1. .00 64. .10 ISG 244
ATOM 244 OE2 GLU 31 131. .253 32 .739 22, .398 1. .00 64. .10 ISG 245
ATOM 245 C GLU 31 136. .071 31, .128 19, .071 1. .00 64. .10 ISG 246
ATOM 246 O GLU 31 136. .904 30, .819 19 .917 1. .00 64. .10 ISG 247
ATOM 247 N LYS ' 32 135. .986 30, .454 17, .910 1. .00 65, .95 ISG 248
ATOM 248 CA LYS 32 136. .758 29. .250 17, .687 1. .00 65. .95 ISG 249
ATOM 249 CB LYS 32 136. .552 28. .631 16, .289 1. .00 65, .95 ISG 250
ATOM 250 CG LYS 32 137. .139 29. .440 15, .128 1. .00 65. .95 ISG 251
ATOM 251 CD LYS 32 138. .662 29, .348 14, .991 1. ,00 65. .95 ISG 252
ATOM 252 CE LYS 32 139. .233 30, .161 13, .827 1. .00 65. .95 ISG 253
ATOM 253 NZ LYS 32 140. .704 30. .012 13, .780 1. .00 65. .95 ISG 254
ATOM 254 C LYS 32 138, .230 29. .448 17, .899 1. .00 65. .95 ISG 255
ATOM 255 O LYS 32 138. .772 30, .534 17, .708 1. .00 65. .95 ISG 256
ATOM 256 N LYS 33 138. .924 28. .370 18, .332 1. .00 65. .10 ISG 257
ATOM 257 CA LYS 33 140. .340 28. .467 18, .558 1. .00 65. .10 ISG 258
ATOM 258 CB LYS 33 140. .768 28. .167 20, .008 1. ,00 65. .10 ISG 259
ATOM 259 CG LYS 33 140. .240 29. .158 21, .047 1. .00 65. .10 ISG 260
ATOM 260 CD LYS 33 138. .741 29. .025 21, .320 1. .00 65. .10 ISG 261
ATOM 261 CE LYS 33 138. .216 30. .017 22. .360 1. .00 65. .10 ISG 262
ATOM 262 NZ LYS 33 138. .797 29. .712 23. .687 1. ,00 65. .10 ISG 263 ATOM 263 C LYS 33 141..050 27.457 17.706 1.00 65.10 ISG 264
ATOM 264 O LYS 33 140. .704 26, .277 17 .694 1, .00 65 .10 ISG 265
ATOM 265 N LEU 34 142 .079 27 .903 16 .959 1 .00 66 .24 ISG 266
ATOM 266 CA LEU 34 142. .848 26 .966 16 .194 1, .00 66 .24 ISG 267
ATOM 267 CB LEU 34 142, .846 27 .185 14, .666 1 .00 66 .24 ISG 268
ATOM 268 CG LEU 34 143 .472 28 .489 14 .149 1, .00 66 .24 ISG 269
ATOM 269 CD2 LEU 34 143, .076 28, .724 12. .682 1. .00 66 .24 ISG 270
ATOM 270 CDl LEU 34 144 .994 28 .527 14 .362 1, .00 66 .24 ISG 271
ATOM 271 C LEU 34 144, .248 26 .957 16 .736 1, .00 66 .24 ISG 272
ATOM 272 O LEU 34 144, .725 27 .924 17 .329 1, .00 66 .24 ISG 273
ATOM 273 N PRO 35 144. .898 25 .843 16 .548 1, .00 64 .20 ISG 274
ATOM 274 CA PRO 35 146. .224 25 .627 17 .071 1 .00 64 .20 ISG 275
ATOM 275 CD PRO 35 144, .171 24. .596 16 .393 1, .00 64 .20 ISG 276
ATOM 276 CB PRO 35 146 .433 24 .110 17 .087 1, .00 64 .20 ISG 277
ATOM 277 CG PRO 35 145, .274 23 .541 16 .249 1, .00 64 .20 ISG 278
ATOM 278 C PRO 35 147, .313 26 .365 16 .355 1, .00 64 .20 ISG 279
ATOM 279 O PRO 35 147, .071 26 .944 15 .300 1, .00 64 .20 ISG 280
ATOM 280 N ASP 36 148 .523 26 .386 16 .946 1 .00 59 .88 ISG 281
ATOM 281 CA ASP 36 149, .636 27 .062 16 .345 1, .00 59 .88 ISG 282
ATOM 282 CB ASP 36 150. .438 27. .915 17, .342 1. .00 59, .88 ISG 283
ATOM 283 CG ASP 36 150. .957 27 .009 18 .446 1, .00 59 .88 ISG 284
ATOM 284 ODl ASP 36 150. .145 26, .216 18 .993 1, .00 59, .88 ISG 285
ATOM 285 OD2 ASP 36 152. .175 27 .094 18 .755 1, .00 59 .88 ISG 286
ATOM 286 C ASP 36 150, .552 26 .046 15, .731 1, .00 59, .88 ISG 287
ATOM 287 O ASP 36 150, .715 24 .942 16 .248 1, .00 59 .88 ISG 288
ATOM 288 N LEU 37 151, .163 26 .393 14, .577 1, .00 56, .08 ISG 289
ATOM 289 CA LEU 37 152 .032 25 .464 13 .911 1, .00 56 .08 ISG 290
ATOM 290 CB LEU 37 151, .571 25, .122 12, .483 1. .00 56, .08 ISG 291
ATOM 291 CG LEU 37 150 .209 24 .399 12 .461 1, .00 56 .08 ISG 292
ATOM 292 CD2 LEU 37 150, .218 23 .173 13 .388 1. .00 56, .08 ISG 293
ATOM 293 CDl LEU 37 149 .764 24 .062 11 .030 1, .00 56 .08 ISG 294
ATOM 294 C LEU 37 153, .408 26 .043 13 .815 1. .00 56, .08 ISG 295
ATOM 295 O LEU 37 153, .582 27 .210 13. .465 1, .00 56, .08 ISG 296
ATOM 296 N SER 38 154, .430 25 .214 14, .120 1. .00 53, .31 ISG 297
ATOM 297 CA SER 38 155. .794 25, .655 14, .096 1. .00 53, .31 ISG 298
ATOM 298 CB SER 38 156. .355 25 .818 15, .513 1. .00 53, .31 ISG 299
ATOM 299 OG SER 38 155. .648 26, .843 16, .197 1. .00 53, .31 ISG 300
ATOM 300 C SER 38 156, .632 24 .639 13, .340 1. .00 53, .31 ISG 301
ATOM 301 0 SER 38 156 , .311 23, .451 13, .318 1. .00 53, .31 ISG 302
ATOM 302 N GLY 39 157, .735 25, .104 12, .694 1. .00 51, .71 ISG 303
ATOM 303 CA GLY 39 158. .635 24, .316 11, .874 1. .00 51. .71 ISG 304
ATOM 304 C GLY 39 159. .618 25, .252 11, .183 1. .00 51, .71 ISG 305
ATOM 305 O GLY 39 159. .322 26, .409 10, ,922 1. ,00 51. .71 ISG 306
ATOM 306 N SER 40 160. .840 24, .800 10, ,835 1. .00 51, .16 ISG 307
ATOM 307 CA SER 40 161. .820 25, .710 10. ,267 1. .00 51. .16 ISG 308
ATOM 308 CB SER 40 163. .266 25, .268 10. .561 1. .00 51. .16 ISG 309
ATOM 309 OG SER 40 164. .192 26, .183 9. .996 1. .00 51. .16 ISG 310
ATOM 310 C SER 40 161. .664 25. ,808 8. .772 1. 00 51. ,16 ISG 311
ATOM 311 O SER 40 160. .989 24. .982 8. .163 1. .00 51. .16 ISG 312
ATOM 312 N GLU 41 162. ,269 26. .849 8. .135 1. 00 49. ,61 ISG 313
ATOM 313 CA GLU 41 162. .186 26. .941 6. .696 1. .00 49. .61 ISG 314
ATOM 314 CB GLU 41 160. .861 27. .527 6. .179 1. 00 49. ,61 ISG 315
ATOM 315 CG GLU 41 159. ,669. 26. .586 6. .368 1. .00 49. ,61 ISG 316
ATOM 316 CD GLU 41 158. ,427 27. ,272 5. ,822 1. 00 49. ,61 ISG 317
ATOM 317 OEl GLU 41 158. ,479 28. .512 5. ,605 1. 00 49. ,61 ISG 318
ATOM 318 OE2 GLU 41 157. 409 26. .561 5. ,613 1. 00 49. ,61 ISG 319
ATOM 319 C GLU 41 163. ,285 27. .802 6. ,160 1. 00 49. ,61 ISG 320 ATOM 320 O GLU 41 163.858 28.625 6.871 1.00 49.61 ISG 321
ATOM 321 N SER 42 163 .626 27 .590 4 .870 1, .00 45. .64 ISG 322
ATOM 322 CA SER 42 164 .606 28 .397 4 .206 1 .00 45 .64 ISG 323
ATOM 323 CB SER 42 166 .005 27 .759 4 .170 1 .00 45, .64 ISG 324
ATOM 324 OG SER 42 165 .976 26 .562 3 .408 1 .00 45 .64 ISG 325
ATOM 325 C SER 42 164 .153 28 .554 2 .788 1 .00 45 .64 ISG 326
ATOM 326 O SER 42 163 .875 27 .575 2 .098 1 .00 45 .64 ISG 327
ATOM 327 N LEU 43 164 .059 29 .812 2 .318 1 .00 43 .05 ISG 328
ATOM 328 CA LEU 43 163 .685 30 .069 0 .958 1 .00 43, .05 ISG 329
ATOM 329 CB LEU 43 162 .456 30 .995 0 .846 1 .00 43 .05 ISG 330
ATOM 330 CG LEU 43 161 .838 31 .122 -0 .563 1 .00 43, .05 ISG 331
ATOM 331 CD2 LEU 43 162 .868 31 .515 -1 .630 1 .00 43 .05 ISG 332
ATOM 332 CDl LEU 43 160 .625 32 .066 -0 .545 1 .00 43, .05 ISG 333
ATOM 333 C LEU 43 164 .876 30 .775 0 .397 1 .00 43 .05 ISG 334
ATOM 334 O LEU 43 165 .410 31 .682 1 .031 1 .00 43, .05 ISG 335
ATOM 335 N GLU 44 165 .327 30 .389 -0 .811 1, .00 40, .67 ISG 336
ATOM 336 CA GLU 44 166 .546 30 .957 -1 .311 1 .00 40 .67 ISG 337
ATOM 337 CB GLU 44 166 .923 30 .432 -2 .707 1 .00 40, .67 ISG 338
ATOM 338 CG GLU 44 165 .894 30 .761 -3 .790 1 .00 40 .67 ISG 339
ATOM 339 CD GLU 44 166 .403 30 .183 -5 .104 1 .00 40, .67 ISG 340
ATOM 340 OEl GLU 44 166 .711 28 .962 -5 .131 1, .00 40, .67 ISG 341
ATOM 341 OE2 GLU 44 166 .498 30 .956 -6 .095 1 .00 40 .67 ISG 342
ATOM 342 C GLU 44 166, .400 32. .440 -1 .405 1, .00 40, .67 ISG 343
ATOM 343 O GLU 44 167 .270 33 .184 -0 .954 1 .00 40 .67 ISG 344
ATOM 344 N PHE 45 165 .292 32 .916 -1 .997 1, .00 40, .18 ISG 345
ATOM 345 CA PHE 45 165 .108 34 .331 -2 .117 1 .00 40 .18 ISG 346
ATOM 346 CB PHE 45 163 .917 34 .706 -3 .014 1, .00 40, .18 ISG 347
ATOM 347 CG PHE 45 164, .253 34. .307 -4, .410 1, .00 40, .18 ISG 348
ATOM 348 CDl PHE 45 164 .030 33 .021 -4 .844 1, .00 40, .18 ISG 349
ATOM 349 CD2 PHE 45 164, .791 35. .222 -5. .285 1, .00 40, .18 ISG 350
ATOM 350 CE1 PHE 45 164 .339 32 .654 -6 .133 1. .00 40 .18 ISG 351
ATOM 351 CE2 PHE 45 165, .103 34, .860 -6, .575 1, .00 40, .18 ISG 352
ATOM 352 CZ PHE 45 164, .877 33. .574 -7. .001 1. .00 40. .18 ISG 353
ATOM 353 C PHE 45 164, .859 34. .957 -0, .777 1. .00 40. .18 ISG 354
ATOM 354 O PHE 45 165, .512 35, .934 -0, .414 1. .00 40. .18 ISG 355
ATOM 355 N LEU 46 163, .899 34. .403 -0, .006 1, .00 42. .89 ISG 356
ATOM 356 CA LEU 46 163, .483 35, .048 1, .210 1. .00 42. .89 ISG 357
ATOM 357 CB LEU 46 162, .220 34 .406 1, .810 1. .00 42. .89 ISG 358
ATOM 358 CG LEU 46 161, .745 35, .074 3 , .114 1. .00 42. .89 ISG 359
ATOM 359 CD2 LEU 46 160. .621 34. .262 3. .778 1. ,00 42. .89 ISG 360
ATOM 360 CDl LEU 46 161. .352 36, .541 2. .875 1. .00 42. .89 ISG 361
ATOM 361 C LEU 46 164. .540 35, .049 2. ,270 1. .00 42. ,89 ISG 362
ATOM 362 O LEU 46 164. .931 36, .125 2. .717 1. .00 42. .89 ISG 363
ATOM 363 N LYS 47 165. .032 33. .849 2. .664 1. ,00 45. .34 ISG 364
ATOM 364 CA LYS 47 166. .015 33. .639 3. .703 1. .00 45. .34 ISG 365
ATOM 365 CB LYS 47 166. .231 34. .803 4. .696 1. .00 45. .34 ISG 366
ATOM 366 CG LYS 47 167. .510 34. .696 5. ,532 1. ,00 45. ,34 ISG 367
ATOM 367 CD LYS 47 168. .793 34. .857 4. .715 1. .00 45. ,34 ISG 368
ATOM 368 CE LYS 47 170. .069 34. .750 5. ,552 1. 00 45. ,34 ISG 369
ATOM 369 NZ LYS 47 171. .258 34. .911 4. .685 1. .00 45. .34 ISG 370
ATOM 370 C LYS 47 165. .511 32. .488 4. .517 1. 00 45. .34 ISG 371
ATOM 371 O LYS 47 164. ,581 31. .789 4. .117 1. 00 45. 34 ISG 372
ATOM 372 N VAL 48 166. ,128 32. .243 5. ,689 1. 00 45. 94 ISG 373
ATOM 373 CA VAL 48 165. ,640 31. ,183 6. ,515 1. 00 45. 94 ISG 374
ATOM 374 CB VAL 48 166. .725 30. ,410 7. ,212 1. 00 45. 94 ISG 375
ATOM 375 CGI VAL 48 167. 564 29. ,690 6. 143 1. 00 45. 94 ISG 376
ATOM 376 CG2 VAL 48 167. .548 31. ,370 8. ,088 1. 00 45. 94 ISG 377 ATOM 377 C VAL 48 164..755 31..799 7..550 1..00 45..94 ISG 378
ATOM 378 O VAL 48 165. .160 32. .702 8. .282 1. .00 45. .94 ISG 379
ATOM 379 N ASP 49 163. .490 31. .340 7. .609 1. ,00 46. .37 ISG 380
ATOM 380 CA ASP 49 162. .584 31. .842 8. .594 1. ,00 46. .37 ISG 381
ATOM 381 CB ASP 49 161. .216 32. .279 8. .023 1. ,00 46. .37 ISG 382
ATOM 382 CG ASP 49 160, .540 31. .119 7. .299 1. ,00 46. .37 ISG 383
ATOM 383 ODl ASP 49 161, .256 30. .159 6. .907 1. ,00 46. .37 ISG 384
ATOM 384 OD2 ASP 49 159. .294 31. .182 7. .126 1. .00 46. .37 ISG 385
ATOM 385 C ASP 49 162, .406 30. .758 9. .593 1. .00 46. .37 ISG 386
ATOM 386 O ASP 49 161, .700 29. .772 9. .378 1. .00 46. .37 ISG 387
ATOM 387 N TYR 50 163 , .112 30. .896 10. .721 1. .00 51. .14 ISG 388
ATOM 388 CA TYR 50 163 .008 29. .872 11. .694 1. .00 51. .14 ISG 389
ATOM 389 CB TYR 50 164 .327 29 .088 11. .839 1, .00 51. .14 ISG 390
ATOM 390 CG TYR 50 164 .251 28, .184 13. .020 1. .00 51 .14 ISG 391
ATOM 391 CDl TYR 50 163 .606 26, .973 12. .943 1. .00 51 .14 ISG 392
ATOM 392 CD2 TYR 50 164 .848 28, .547 14. .207 1. .00 51 .14 ISG 393
ATOM 393 CE1 TYR 50 163 .542 26 .140 14. .036 1. .00 51 .14 ISG 394
ATOM 394 CE2 TYR 50 164 .787 27, .719 15. .303 1, .00 51 .14 ISG 395
ATOM 395 CZ TYR 50 164 .132 26 .514 15. .219 1, .00 51 .14 ISG 396
ATOM 396 OH TYR 50 164 .069 25 .662 16. .342 1. .00 51 .14 ISG 397
ATOM 397 C TYR 50 162 .705 30 .485 13. .012 1. .00 51 .14 ISG 398
ATOM 398 O TYR 50 163 .565 31 .061 13, .669 1, .00 51 .14 ISG 399
ATOM 399 N VAL 51 161 .442 30, .362 13, .424 1, .00 55 .84 ISG 400
ATOM 400 CA VAL 51 161 .080 30, .575 14, .784 1. .00 55 .84 ISG 401
ATOM 401 CB VAL 51 159 .667 31 .040 14, .970 1, .00 55 .84 ISG 402
ATOM 402 CGI VAL 51 159 .358 31, .081 16, .476 1, .00 55 .84 ISG 403
ATOM 403 CG2 VAL 51 159 .504 32 .399 14, .266 1. .00 55 .84 ISG 404
ATOM 404 C VAL 51 161 .126 29, .130 15, .050 1. .00 55 .84 ISG 405
ATOM 405 0 VAL 51 162 .182 28 .530 14, .852 1. .00 55 .84 ISG 406
ATOM 406 N ASN 52 160 .083 28, .498 15, .583 1. .00 63 .96 ISG 407
ATOM 407 CA ASN 52 160 .276 27, .155 15, .162 1. .00 63 .96 ISG 408
ATOM 408 ' CB ASN 52 159 .257 26, .166 15, .735 1. .00 63 .96 ISG 409
ATOM 409 CG ASN 52 159 .671 24, .764 15, .313 1. .00 63 .96 ISG 410
ATOM 410 ODl ASN 52 160, .110 24, .545 14, .185 1. .00 63 .96 ISG 411
ATOM 411 ND2 ASN 52 159, .533 23, .785 16, .246 1, .00 63 .96 ISG 412
ATOM 412 C ASN 52 160, .034 27, .347 13, .681 1. .00 63 .96 ISG 413
ATOM 413 O ASN 52 160, .866 27, .019 12, .840 1. .00 63. .96 ISG 414
ATOM 414 N TYR 53 158, .890 28, .015 13. .411 1, .00 71. .81 ISG 415
ATOM 415 CA TYR 53 158, .215 28, .528 12, .238 1, .00 71. .81 ISG 416
ATOM 416 CB TYR 53 157, .063 27, .633 11, .776 1. .00 71, .81 ISG 417
ATOM 417 CG TYR 53 156, .599 27, .753 10, .376 1. .00 71, .81 ISG 418
ATOM 418 CDl TYR 53 155, .805 28. .786 9, .941 1. .00 71, .81 ISG 419
ATOM 419 CD2 TYR 53 156, .946 26. .746 9, .507 1. .00 71. .81 ISG 420
ATOM 420 CE1 TYR 53 155, .386 28. .806 8, .633 1. .00 71. .81 ISG 421
ATOM 421 CE2 TYR 53 156, .529 26. .763 8. .204 1. .00 71. .81 ISG 422
ATOM 422 CZ TYR 53 155. .746 27. .799 7. .769 1. .00 71. .81 ISG 423
ATOM 423 OH TYR 53 155. .307 27. .817 6. .433 1. .00 71. .81 ISG 424
ATOM 424 C TYR 53 157. .353 29. .430 12. .996 1. .00 71. .81 ISG 425
ATOM 425 O TYR 53 157. .381 29. .336 14. .217 1. .00 71. .81 ISG 426
ATOM 426 N ASN 54 156. .546 30. .296 12. .382 1. .00 67. .94 ISG 427
ATOM 427 CA ASN 54 155. .731 30. .880 13. .384 1. .00 67. .94 ISG 428
ATOM 428 CB ASN 54 156. .311 32. .184 13. .957 1. .00 67. .94 ISG 429
ATOM 429 CG ASN 54 155. .509 32. .573 15. .193 1. .00 67. .94 ISG 430
ATOM 430 ODl ASN 54 154. .285 32. .694 15. .154 1. ,00 67. .94 ISG 431
ATOM 431 ND2 ASN 54 156. .222 32. .771 16. ,333 1. ,00 67. ,94 ISG 432
ATOM 432 C ASN 54 154. .380 31. ,186 12. ,864 1. .00 67. ,94 ISG 433
ATOM 433 O ASN 54 154. .151 32. .245 12. .286 1. .00 67, .94 ISG 434 ATOM 434 N PHE 55 153.446 30.244 13.044 1.00 65.03 ISG 435
ATOM 435 CA PHE 55 152 .085 30 .601 12 .826 1 .00 65 .03 ISG 436
ATOM 436 CB PHE 55 151 .366 29 .826 11 .708 1 .00 65 .03 ISG 437
ATOM 437 CG PHE 55 151 .739 30 .470 10 .415 1 .00 65 .03 ISG 438
ATOM 438 CDl PHE 55 151 .088 31 .615 10 .013 1 .00 65 .03 ISG 439
ATOM 439 CD2 PHE 55 152 .717 29 .947 9 .601 1 .00 65 .03 ISG 440
ATOM 440 CE1 PHE 55 151 .405 32 .234 8 .827 1 .00 65 .03 ISG 441
ATOM 441 CE2 PHE 55 153 .036 30 .565 8 .413 1 .00 65 .03 ISG 442
ATOM 442 CZ PHE 55 152 .384 31 .708 8 .022 1 .00 65 .03 ISG 443
ATOM 443 C PHE 55 151 .444 30 .290 14 .127 1 .00 65 .03 ISG 444
ATOM 444 o PHE 55 151 .245 29 .124 14, .464 1 .00 65 .03 ISG 445
ATOM 445 N SER 56 151 .130 31 .337 14 .909 1 .00 61 .50 ISG 446
ATOM 446 CA SER 56 150 .577 31 .089 16 .202 1, .00 61 .50 ISG 447
ATOM 447 CB SER 56 151 .645 30. .861 17, .286 1, .00 61 .50 ISG 448
ATOM 448 OG SER 56 152 .477 29. .765 16, .936 1, .00 61 .50 ISG 449
ATOM 449 C SER 56 149 .825 32. .310 16, .598 1, .00 61 .50 ISG 450
ATOM 450 O SER 56 149 .939 33. .356 15, .961 1, .00 61 .50 ISG 451
ATOM 451 N ASN 57 149 .032 32. .191 17, .679 1, .00 61 .09 ISG 452
ATOM 452 CA ASN 57 148 .268 33, .295 18, .169 1, .00 61 .09 ISG 453
ATOM 453 CB ASN 57 149 .137 34, .438 18, .722 1, .00 61 .09 ISG 454
ATOM 454 CG ASN 57 149 .813 33, .943 19, .993 1, .00 61, .09 ISG 455
ATOM 455 ODl ASN 57 151, .039 33, .907 20, .086 1, .00 61, .09 ISG 456
ATOM 456 ND2 ASN 57 148, .992 33 , .549 21, .003 1, .00 61, .09 ISG 457
ATOM 457 C ASN 57 147 .462 33 .827 17 .036 1 .00 61 .09 ISG 458
ATOM 458 O ASN 57 147 .371 35 .039 16 .846 1 .00 61 .09 ISG 459
ATOM 459 N ILE 58 146 .833 32 .933 16 .248 1 .00 68 .20 ISG 460
ATOM 460 CA ILE 58 146 .083 33 .473 15, .165 1 .00 68 .20 ISG 461
ATOM 461 CB ILE 58 146 .265 32, .769 13 .842 1 .00 68 .20 ISG 462
ATOM 462 CG2 ILE 58 147 .764 32, .834 13, .505 1 .00 68 .20 ISG 463
ATOM 463 CGI ILE 58 145 .699 31, .341 13, .837 1, .00 68 .20 ISG 464
ATOM 464 CDl ILE 58 144 .189 31, .291 13 , .609 1 .00 68 .20 ISG 465
ATOM 465 C ILE 58 144 .666 33, .413 15, .578 1, .00 68 .20 ISG 466
ATOM 466 O ILE 58 144 .193 32, .414 16, .115 1, .00 68 .20 ISG 467
ATOM 467 N LYS 59 143 .955 34, .526 15, .374 1, .00 72 .68 ISG 468
ATOM 468 CA LYS 59 142, .602 34, .537 15. .797 1, .00 72 .68 ISG 469
ATOM 469 CB LYS 59 142, .280 35, .659 16. .799 1, .00 72 .68 ISG 470
ATOM 470 CG LYS 59 142. .986 35, .494 18. .146 1, .00 72, .68 ISG 471
ATOM 471 CD LYS 59 142, .616 34 , .201 18. .876 1, .00 72. .68 ISG 472
ATOM 472 CE LYS 59 141, .194 34, .201 19. .440 1, .00 72. .68 ISG 473
ATOM 473 NZ LYS 59 140. .922 32. .919 20. .127 1. .00 72. .68 ISG 474
ATOM 474 C LYS 59 141. .789 34. .769 14. .586 1. .00 72. .68 ISG 475
ATOM 475 O LYS 59 142. .296 35. .137 13. .527 1, .00 72, .68 ISG 476
ATOM 476 N ILE 60 140, .486 34. .505 14. .711 1. .00 83, .69 ISG 477
ATOM 477 CA ILE 60 139, .634 34. .800 13. .622 1. .00 83. .69 ISG 478
ATOM 478 CB ILE 60 138. .225 34. .432 13. .936 1. .00 83. .69 ISG 479
ATOM 479 CG2 ILE 60 137. .316 34. .811 12. .755 1. .00 83, .69 ISG 480
ATOM 480 CGI ILE 60 138. .200 32. .944 14. .289 1. .00 83, .69 ISG 481
ATOM 481 CDl ILE 60 136, .959 32. .558 15. .071 1. .00 83, .69 ISG 482
ATOM 482 C ILE 60 139, .732 36. .268 13. .560 1. .00 83, .69 ISG 483
ATOM 483 O ILE 60 139, .444 36. .946 14. .547 1. .00 83, .69 ISG 484
ATOM 484 N SER 61 140, .197 36. .780 12. .409 1. .00 88. .65 ISG 485
ATOM 485 CA SER 61 140, .424 38. .186 12. .325 1. .00 88. .65 ISG 486
ATOM 486 CB SER 61 141, .102 38. .609 11. .008 1. ,00 88. .65 ISG 487
ATOM 487 OG SER 61 140, .288 38. .278 9. .893 1. ,00 88. .65 ISG 488
ATOM 488 C SER 61 139. .117 38. ,868 12. ,427 1. ,00 88. .65 ISG 489
ATOM 489 O SER 61 138. .891 39. ,711 13. ,291 1. ,00 88. ,65 ISG 490
ATOM 490 N ALA 62 138. .204 38. .490 11. 531 1. ,00 92. .86 ISG 491 ATOM 491 CA ALA 62 136..913 39..076 11..561 1,,00 92..86 ISG 492
ATOM 492 CB ALA 62 136. .776 40. .309 10. .654 1, ,00 92. .86 ISG 493
ATOM 493 C ALA 62 136. .061 38. .022 10, .998 1, ,00 92. .86 ISG 494
ATOM 494 O ALA 62 136. .544 37. .193 10. .229 1. 00 92. .86 ISG 495
ATOM 495 N PHE 63 134. .789 37, .989 11. .409 1. ,00 98, .82 ISG 496
ATOM 496 CA PHE 63 133, .955 36. .991 10. .837 1, ,00 98, .82 ISG 497
ATOM 497 CB PHE 63 133, .418 36. .021 11. .903 1. .00 98, .82 ISG 498
ATOM 498 CG PHE 63 132 .613 34. .820 11. .148 1. .00 98 .82 ISG 499
ATOM 499 CDl PHE 63 131. .301 34. .684 10. .695 1. ,00 98. .82 ISG 500
ATOM 500 CD2 PHE 63 132, .529 33. .516 10. .562 1. ,00 98. .82 ISG 501
ATOM 501 CE1 PHE 63 131, .578 33. .372 10. .217 1. .00 98. .82 ISG 502
ATOM 502 CE2 PHE 63 131, .617 34. .493 10. .713 1. .00 98. .82 ISG 503
ATOM 503 CZ PHE 63 132, .772 33. .725 10. .730 1. .00 98. .82 ISG 504
ATOM 504 C PHE 63 132. .796 37. .741 10. .269 1. ,00 98. .82 ISG 505
ATOM 505 0 PHE 63 131. .790 37. .940 10. .946 1. .00 98, .82 ISG 506
ATOM 506 N SER 64 132. .892 38. .149 8. .990 1. .00 87, .01 ISG 507
ATOM 507 CA SER 64 131 .833 38. .936 8, .437 1. .00 87 .01 ISG 508
ATOM 508 CB SER 64 132. .317 40, .045 7, .488 1, .00 87. .01 ISG 509
ATOM 509 OG SER 64 132. .933 39, .474 6. .344 1. .00 87. .01 ISG 510
ATOM 510 C SER 64 130. .958 38, .026 7. .653 1. .00 87. .01 ISG 511
ATOM 511 0 SER 64 131 .418 37, .250 6. .818 1, .00 87 .01 ISG 512
ATOM 512 N PHE 65 129. .649 38. .106 7. .935 1. ,00 78. .47 ISG 513
ATOM 513 CA PHE 65 128. .663 37. .284 7. .305 1. .00 78 .47 ISG 514
ATOM 514 CB PHE 65 127. .828 36. .669 8 .440 1. .00 78 .47 ISG 515
ATOM 515 CG PHE 65 127 .019 35, .489 8. .056 1. .00 78 .47 ISG 516
ATOM 516 CDl PHE 65 125 .749 35. .636 7 .556 1. .00 78 .47 ISG 517
ATOM 517 CD2 PHE 65 127. .536 34. .228 8, .232 1. .00 78 .47 ISG 518
ATOM 518 CE1 PHE 65 125, .013 34. .526 7 .226 1. .00 78, .47 ISG 519
ATOM 519 CE2 PHE 65 126 .800 33. .118 7 .904 1. .00 78 .47 ISG 520
ATOM 520 CZ PHE 65 125 .533 33, .267 7 .397 1, .00 78 .47 ISG 521
ATOM 521 C PHE 65 127 .781 38, .273 6, .595 1. .00 78 .47 ISG 522
ATOM 522 0 PHE 65 126, .722 38. .623 7 .112 1. .00 78 .47 ISG 523
ATOM 523 N PRO 66 128 .173 38. .746 5, .440 1. .00 66, .01 ISG 524
ATOM 524 CA PRO 66 127 .406 39. .756 4, .759 1. .00 66 .01 ISG 525
ATOM 525 CD PRO 66 129 .575 38. .780 5 .062 1. .00 66 .01 ISG 526
ATOM 526 CB PRO 66 128, .291 40. .261 3. .622 1. .00 66, .01 ISG 527
ATOM 527 CG PRO 66 129, .718 39, .992 4, .127 1. .00 66, .01 ISG 528
ATOM 528 C PRO 66 126, .055 39, .335 4. .296 1. .00 66 .01 ISG 529
ATOM 529 0 PRO 66 125, .105 40, .100 4. .460 1, .00 66 .01 ISG 530
ATOM 530 N ASN 67 125 .934 38, .128 3. .723 1. .00 51 .28 ISG 531
ATOM 531 CA ASN 67 124, .655 37, .755 3. .210 1. .00 51, .28 ISG 532
ATOM 532 CB ASN 67 124, .586 37, .746 1, .673 1. .00 51 .28 ISG 533
ATOM 533 CG ASN 67 123. .147 37, .455 1. .269 1. .00 51 .28 ISG 534
ATOM 534 ODl ASN 67 122 .227 38, .187 1. .629 1. .00 51 .28 ISG 535
ATOM 535 ND2 ASN 67 122. .945 36. ,353 0, .498 1. .00 51. .28 ISG 536
ATOM 536 C ASN 67 124. .363 36. .376 3 , .669 1. ,00 51 .28 ISG 537
ATOM 537 0 ASN 67 125. .262 35. .549 3. .815 1. .00 51. .28 ISG 538
ATOM 538 N THR 68 123 .074 36. .109 3. .937 1. .00 45 .70 ISG 539
ATOM 539 CA THR 68 122. .684 34. .796 4 .353 1. .00 45 .70 ISG 540
ATOM 540 CB THR 68 122. .436 34. .695 5. .824 1. .00 45. .70 ISG 541
ATOM 541 OGl THR 68 122, .203 33. .344 6, .191 1. .00 45. .70 ISG 542
ATOM 542 CG2 THR 68 121. .229 35, .578 6. .180 1. .00 45, .70 ISG 543
ATOM 543 C THR 68 121. .379 34, .500 3. .691 1. .00 45, .70 ISG 544
ATOM 544 0 THR 68 120. .607 35. .407 3. .390 1. ,00 45. .70 ISG 545
ATOM 545 N SER 69 121. .107 33. .210 3. .425 1. .00 38. .73 ISG 546
ATOM 546 CA SER 69 119. .852 32. .837 2. .845 1. .00 38, .73 ISG 547
ATOM 547 CB SER 69 119, .864 32. .829 1. .307 1. .00 38, .73 ISG 548 P P P P > P > > P P P > > P P P P P P P P
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H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H to to to to to to m to to to to W to to to to to to to to to to to to to to to to to to to to to to to m to to to to to to to to to W to to to to to m w to to to to Ω ΩΩΩ Ώ Ώ Ω Ω Ω ΩΩ ΩΩΩ Ω Ω Ώ Ω Ω Ω Ω ΩΩ Ω ΩΏ ΏΩ Ω ΩΩ Ω ΩΩ ΩΩ Ω ΩΩ ΩΩΩΩ Ω ΩΩ Ω Ω Ω ΩΏ ΩΩ Ω Ω Ω Ω eD CD CD CO 00 0O 00 σj eD 00 CD CD CD CD ∞ 00 0O CO CO Cθ α0 eD CD CD CD CD CD CD ∞ 00 00 CD CD CO CD 00 00 O0 O0 CD 00 CD vo ∞ ∞ CD m co ∞ CD ∞ m cD s] si s] si si si s] si s! si en cn en en en cn cn -i _i -i ιn uι uι uι uι ιn uι _i to Ui ιf* 4* 4* 4^ o vo oo si cn _i ι^ uJ tθ H θ VD θo -j en ui 4* UJ tθ H θ vo oo si cn ιn 4* UJ t H o vo oo s] en uι 4* uJ tθ H θ vo CD si en ιn 4* uJ tθ H θ vo oo s σι uι 4*
ATOM 890 CB ILE 114 145.220 25.371 8.823 1.00 57.23 ISG 891
ATOM 891 CG2 ILE 114 144. 297 26. 525 9. 248 1. 00 57. 23 ISG 892
ATOM 892 CGI ILE 114 146. ,586 25. 384 9. 529 1. 00 57. .23 ISG 893
ATOM 893 CDl ILE 114 146. ,487 25. 266 11. 050 1. ,00 57. 23 ISG 894
ATOM 894 C ILE 114 143. ,145 24. 188 8. 498 1. 00 57. 23 ISG 895
ATOM 895 0 ILE 114 142. ,163 24. 388 9. .211 1. ,00 57. .23 ISG 896
ATOM 896 N LEU 115 143. .046 24. .042 7. 164 1. ,00 59. 16 ISG 897
ATOM 897 CA LEU 115 141, ,785 24. ,205 6. .502 1. ,00 59. .16 ISG 898
ATOM 898 CB LEU 115 141. .876 23. ,969 4. 987 1. .00 59. .16 ISG 899
ATOM 899 CG LEU 115 140. .511 24. ,039 4. .280 1. .00 59. .16 ISG 900
ATOM 900 CD2 LEU 115 140. .621 23. .622 2. .805 1. ,00 59. .16 ISG 901
ATOM 901 CDl LEU 115 139. .865 25. 418 4. 463 1. ,00 59. .16 ISG 902
ATOM 902 C LEU 115 140. 819 23. ,210 7. 039 1. ,00 59. .16 ISG 903
ATOM 903 O LEU 115 139. .676 23. ,552 7. 334 1. .00 59. ,16 ISG 904
ATOM 904 N LYS 116 141. 263 21. .952 7. .189 1. ,00 60. .27 ISG 905
ATOM 905 CA LYS 116 140. ,374 20. ,916 7. 620 1. .00 60. .27 ISG 906
ATOM 906 CB LYS 116 141. ,020 19. .514 7. .575 1. .00 60. ,27 ISG 907
ATOM 907 CG LYS 116 142. .187 19. .281 8. .540 1. ,00 60. .27 ISG 908
ATOM 908 CD LYS 116 141. .767 19. .002 9. ,985 1. .00 60. .27 ISG 909
ATOM 909 CE LYS 116 142. ,946 18. .772 10. ,933 1. .00 60, .27 ISG 910
ATOM 910 NZ LYS 116 143. .650 17. .522 10. .571 1. .00 60. .27 ISG 911
ATOM 911 C LYS 116 139. .874 21. .195 9. .003 1. .00 60. .27 ISG 912
ATOM 912 O LYS 116 138. .687 21. .026 9. .274 1, .00 60. .27 ISG 913
ATOM 913 N ASN 117 140. .761 21. .634 9. .915 1. .00 61. .29 ISG 914
ATOM 914 CA ASN 117 140. .370 21. .867 11. .277 1. .00 61, .29 ISG 915
ATOM 915 CB ASN 117 141, .564 22, .217 12. .183 1, .00 61. .29 ISG 916
ATOM 916 CG ASN 117 141. .090 22, .211 13. .630 1, .00 61. .29 ISG 917
ATOM 917 ODl ASN 117 140. .107 22, .860 13. .984 1, .00 61. .29 ISG 918
ATOM 918 ND2 ASN 117 141. .809 21, .448 14. .496 1, .00 61. .29 ISG 919
ATOM 919 C ASN 117 139. .412 23, .007 11. .333 1, .00 61, .29 ISG 920
ATOM 920 O ASN 117 138. .433 22, .981 12. .076 1 .00 61 .29 ISG 921
ATOM 921 N LEU 118 139, .697 24, .054 10. .546 1, .00 64, .59 ISG 922
ATOM 922 CA LEU 118 138, .909 25, .243 10. .535 1 .00 64 .59 ISG 923
ATOM 923 CB LEU 118 139, .591 26 .324 9 .663 1 .00 64 .59 ISG 924
ATOM 924 CG LEU 118 138, .886 27 .691 9. .523 1 .00 64 .59 ISG 925
ATOM 925 CD2 LEU 118 137, .566 27 .586 8 .743 1, .00 64 .59 ISG 926
ATOM 926 CDl LEU 118 139. .820 28 .705 8 .842 1 .00 64 .59 ISG 927
ATOM 927 C LEU 118 137, .542 24 .944 10 .022 1 .00 64 .59 ISG 928
ATOM 928 O LEU 118 136, .543 25 .408 10 .572 1, .00 64 .59 ISG 929
ATOM 929 N ASN 119 137, .454 24 .159 8 .940 1 .00 67 .28 ISG 930
ATOM 930 CA ASN 119 136 .156 23 .881 8 .420 1, .00 67 .28 ISG 931
ATOM 931 CB ASN 119 136, .150 23 .200 7 .035 1 .00 67 .28 ISG 932
ATOM 932 CG ASN 119 136 .923 21 .896 7 .076 1, .00 67 .28 ISG 933
ATOM 933 ODl ASN 119 138 .019 21 .811 6 .526 1 .00 67 .28 ISG 934
ATOM 934 ND2 ASN 119 136 .349 20 .858 7 .736 1 .00 67 .28 ISG 935
ATOM 935 C ASN 119 135 .406 23 .060 9 .416 1 .00 67 .28 ISG 936
ATOM 936 0 ASN 119 134 .192 23 .188 9 .535 1 .00 67 .28 ISG 937
ATOM 937 N GLU 120 136 .114 22 .172 10 .136 1 .00 69 .68 ISG 938
ATOM 938 CA GLU 120 135 .522 21 .311 11 .120 1 .00 69 .68 ISG 939
ATOM 939 CB GLU 120 136 .493 20 .214 11 .597 1 .00 69 .68 ISG 940
ATOM 940 CG GLU 120 135 .867 19 .196 12 .555 1 .00 69 .68 , ISG 941
ATOM 941 CD GLU 120 135 .904 19 .766 13 .966 1 .00 69 .68 ISG 942
ATOM 942 OEl GLU 120 136 .625 20 .777 14 .179 1 .00 69 .68 ISG 943
ATOM 943 OE2 GLU 120 135 .214 19 .193 14 .852 1 .00 69 .68 ISG 944
ATOM 944 C GLU 120 135 .061 22 .070 12 .331 1 .00 69 .68 ISG 945
ATOM 945 0 GLU 120 133 .984 21 .808 12 .841 1 .00 69 .68 ISG 946
ATOM 946 N MET 121 135, .830 23 .030 12 .864 1 .00 72 .88 ISG 947 ATOM 947 CA MET 121 135..385 23..642 14..091 1..00 72..88 ISG 948
ATOM 948 CB MET 121 136. .400 24. .658 14. .637 1. .00 72. .88 ISG 949
ATOM 949 CG MET 121 137. .728 24. .023 15. .052 1. .00 72. .88 ISG 950
ATOM 950 SD MET 121 138. .955 25. .200 15. .692 1. .00 72. .88 ISG 951
ATOM 951 CE MET 121 139, .353 25. .911 14. .069 1. .00 72. .88 ISG 952
ATOM 952 C MET 121 134. .116 24. .373 13. ,845 1. .00 72. .88 ISG 953
ATOM 953 O MET 121 133. .179 24. .363 14. ,642 1. .00 72. .88 ISG 954
ATOM 954 N LEU 122 134. .090 25. .054 12. .705 1. .00 73. .30 ISG 955
ATOM 955 CA LEU 122 133. .017 25. .897 12. .327 1. .00 73. .30 ISG 956
ATOM 956 CB LEU 122 133, .513 26. .712 11. .149 1. .00 73. .30 ISG 957
ATOM 957 CG LEU 122 134. .559 27. .802 11. .480 1. .00 73. .30 ISG 958
ATOM 958 CD2 LEU 122 135, .112 28. .367 10. .169 1. .00 73. .30 ISG 959
ATOM 959 CDl LEU 122 135, .722 27. .315 12. .362 1, .00 73. .30 ISG 960
ATOM 960 C LEU 122 131, .765 25. .092 12. .072 1. .00 73, .30 ISG 961
ATOM 961 O LEU 122 130, .701 25. .465 12. .567 1. .00 73, .30 ISG 962
ATOM 962 N CYS 123 131 .841 23, .947 11. .348 1. .00 69, .71 ISG 963
ATOM 963 CA CYS 123 130 .628 23, .216 11. .079 1. .00 69, .71 ISG 964
ATOM 964 CB CYS 123 130, .780 21. .914 10. .240 1. .00 69. .71 ISG 965
ATOM 965 SG CYS 123 131, .739 21. .967 8. .699 1, .00 69. .71 ISG 966
ATOM 966 C CYS 123 130, .057 22. .802 12. .407 1. .00 69. .71 ISG 967
ATOM 967 O CYS 123 128, .861 22. .985 12. .603 1. .00 69, .71 ISG 968
ATOM 968 N PRO 124 130 .813 22 , .229 13. .324 1, .00 65, .33 ISG 969
ATOM 969 CA PRO 124 130 .225 22, .020 14. .609 1. .00 65, .33 ISG 970
ATOM 970 CD PRO 124 131 .365 20, .926 12. .989 1. .00 65, .33 ISG 971
ATOM 971 CB PRO 124 131 .190 21, .131 15. .393 1. .00 65, .33 ISG 972
ATOM 972 CG PRO 124 131 .999 20, .418 14. .296 1 .00 65 .33 ISG 973
ATOM 973 C PRO 124 129 .738 23, .205 15. .367 1 .00 65 .33 ISG 974
ATOM 974 O PRO 124 128 .814 23, .030 16 .158 1 .00 65 .33 ISG 975
ATOM 975 N ILE 125 130, .315 24. .403 15. .195 1. .00 57, .83 ISG 976
ATOM 976 CA ILE 125 129, .752 25. .490 15. .936 1. .00 57, .83 ISG 977
ATOM 977 CB ILE 125 130, .472 26. .781 15, .684 1. .00 57, .83 ISG 978
ATOM 978 CG2 ILE 125 129, .648 27. .914 16, .313 1. .00 57. .83 ISG 979
ATOM 979 CGI ILE 125 131, .921 26, .698 16, .193 1. .00 57 .83 ISG 980
ATOM 980 CDl ILE 125 132 .025 26, .437 17, .695 1, .00 57. .83 ISG 981
ATOM 981 C ILE 125 128, .347 25, .662 15, .447 1 .00 57, .83 ISG 982
ATOM 982 O ILE 125 127 .408 25, .742 16. .237 1 .00 57, .83 ISG 983
ATOM 983 N ILE 126 128 .165 25, .688 14 .112 1 .00 50 .67 ISG 984
ATOM 984 CA ILE 126 126 .858 25, .903 13 .563 1 .00 50, .67 ISG 985
ATOM 985 CB ILE 126 126 .834 26, .088 12 .067 1 .00 50. .67 ISG 986
ATOM 986 CG2 ILE 126 127, .177 24 , .760 11, .379 1, .00 50. .67 ISG 987
ATOM 987 CGI ILE 126 125, .474 26. .661 11, .634 1, .00 50. .67 ISG 988
ATOM 988 CDl ILE 126 125, .455 27, .156 10, .189 1, .00 50. .67 ISG 989
ATOM 989 C ILE 126 125, .961 24, .770 13. .927 1, .00 50. .67 ISG 990
ATOM 990 O ILE 126 124, .816 24, .982 14 , .320 1, .00 50. .67 ISG 991
ATOM 991 N ALA 127 126, .456 23, .527 13 , .817 1, .00 45. .55 ISG 992
ATOM 992 CA ALA 127 125, .627 22 , .401 14, .124 1, .00 45. .55 ISG 993
ATOM 993 CB ALA 127 126, .344 21. .057 13, .908 1, .00 45. .55 ISG 994
ATOM 994 C ALA 127 125, .223 22. .469 15, .563 1, .00 45. .55 ISG 995
ATOM 995 O ALA 127 124, .060 22. .257 15. .890 1, .00 45, .55 ISG 996
ATOM 996 N SER 128 126, .172 22, .781 16. .463 1, .00 40, .93 ISG 997
ATOM 997 CA SER 128 125, .895 22, .804 17, .873 1, .00 40, .93 ISG 998
ATOM 998 CB SER 128 127. .158 23. .030 18. .721 1. .00 40. ,93 ISG 999
ATOM 999 OG SER 128 127. .697 24. .318 18. .461 1. .00 40. ,93 1SG1000
ATOM 1000 C SER 128 124. .946 23. .912 18. .189 1. .00 40. .93 1SG1001
ATOM 1001 O SER 128 124. .087 23. .778 19. .059 1. .00 40. .93 1SG1002
ATOM 1002 N GLU 129 125. .077 25. .040 17. .474 1. .00 38. .32 1SG1003
ATOM 1003 CA GLU 129 124. .271 26. .189 17. .736 1. .00 38. .32 1SG1004 ATOM 1004 CB GLU 129 124..619 27..381 16,.830 1..00 38..32 1SG1005
ATOM 1005 CG GLU 129 123. .793 28. .633 17, .128 1. .00 38. .32 1SG1006
ATOM 1006 CD GLU 129 124. .274 29. .734 16, .197 1. .00 38. .32 1SG1007
ATOM 1007 OEl GLU 129- 125. .264 29. .489 15, .458 1. .00 38. .32 1SG1008
ATOM 1008 OE2 GLU 129 123. .662 30. .836 16, .214 1. .00 38. .32 1SG1009
ATOM 1009 C GLU 129 122. .848 25, .833 17, .500 1. .00 38. .32 1SG1010
ATOM 1010 O GLU 129 121. .975 26, .311 18 .215 1. .00 38. .32 1SG1011
ATOM 1011 N VAL 130 122, .559 24, .986 16 .497 1. .00 37. .53 1SG1012
ATOM 1012 CA VAL 130 121. .183 24, .679 16 .248 1. .00 37. .53 1SG1013
ATOM 1013 CB VAL 130 120. .946 23, .775 15 .068 1. .00 37, .53 1SG1014
ATOM 1014 CGI VAL 130 121. .368 22, .338 15 .410 1, .00 37, .53 1SG1015
ATOM 1015 CG2 VAL 130 119. .467 23. .897 14, .671 1. .00 37. .53 1SG1016
ATOM 1016 C VAL 130 120. .617 24. .027 17, .464 1. .00 37. .53 1SG1017
ATOM 1017 O VAL 130 119. .484 24. .305 17, .853 1. .00 37. .53 1SG1018
ATOM 1018 N LYS 131 121. .399 23, .148 18, .114 1. .00 36. .58 1SG1019
ATOM 1019 CA LYS 131 120, .903 22, .484 19, .281 1. .00 36. .58 1SG1020
ATOM 1020 CB LYS 131 121, .937 21, .540 19, .915 1. .00 36. .58 1SG1021
ATOM 1021 CG LYS 131 121, .415 20, .805 21 .152 1. .00 36. .58 1SG1022
ATOM 1022 CD LYS 131 122, .305 19, .641 21 .592 1. .00 36. .58 1SG1023
ATOM 1023 CE LYS 131 121, .788 18, .907 22 .831 1. .00 36. .58 1SG1024
ATOM 1024 NZ LYS 131 122, .702 17, .795 23 .179 1. .00 36 .58 1SG1025
ATOM 1025 C LYS 131 120, .581 23, .547 20 .281 1. .00 36 .58 1SG1026
ATOM 1026 O LYS 131 119. .563 23, .479 20 .966 1, .00 36 .58 1SG1027
ATOM 1027 N ALA 132 121. .454 24. .566 20 .379 1. .00 35 .55 1SG1028
ATOM 1028 CA ALA 132 121, .273 25, .656 21 .294 1. .00 35 .55 1SG1029
ATOM 1029 CB ALA 132 122 .448 26, .650 21 .276 1. .00 35 .55 1SG1030
ATOM 1030 C ALA 132 120, .036 26, .419 20, .913 1. .00 35, .55 1SG1031
ATOM 1031 O ALA 132 119, .293 26, .876 21, .779 1. .00 35, .55 1SG1032
ATOM 1032 N LEU 133 119. .792 26, .571 19, .596 1. .00 33, .97 1SG1033
ATOM 1033 CA LEU 133 118. .679 27, .286 19 .041 1, .00 33, .97 1SG1034
ATOM 1034 CB LEU 133 118, .651 27, .247 17, .504 1. .00 33, .97 1SG1035
ATOM 1035 CG LEU 133 119, .862 27, .934 16 .848 1. .00 33 .97 1SG1036
ATOM 1036 CD2 LEU 133 120. .045 29, .366 17, .374 1. .00 33 .97 1SG1037
ATOM 1037 CDl LEU 133 119, .779 27, .867 15, .314 1. .00 33 .97 1SG1038
ATOM 1038 C LEU 133 117, .465 26, .581 19, .528 1. .00 33 .97 1SG1039
ATOM 1039 O LEU 133 116, .426 27, .193 19, .765 1, .00 33 .97 1SG1040
ATOM 1040 N ASN 134 117, .588 25, .256 19, .701 1, .00 31 .35 1SG1041
ATOM 1041 CA ASN 134 116, .493 24, .455 20, .147 1, .00 31 .35 1SG1042
ATOM 1042 CB ASN 134 116, .880 22, .984 20 .373 1. .00 31 .35 1SG1043
ATOM 1043 CG ASN 134 117 .173 22, .361 19 .015 1. .00 31 .35 1SG1044
ATOM 1044 ODl ASN 134 118 .274 21, .873 18 .767 1. .00 31 .35 1SG1045
ATOM 1045 ND2 ASN 134 116. .159 22, .378 18, .109 1. .00 3.1, .35 1SG1046
ATOM 1046 C ASN 134 116, .035 25. .007 21, .458 1. .00 31. .35 1SG1047
ATOM 1047 O ASN 134 114. .842 25. .013 21, .748 1. .00 31. .35 1SG1048
ATOM 1048 N ALA 135 116, .975 25. .493 22, .289 1. .00 31. .41 1SG1049
ATOM 1049 CA ALA 135 116, .615 26. .015 23, .576 1. .00 31. .41 1SG1050
ATOM 1050 CB ALA 135 117. .830 26. .510 24, .379 1. .00 31. .41 1SG1051
ATOM 1051 C ALA 135 115. .691 27. .181 23, .394 1. .00 31. .41 1SG1052
ATOM 1052 O ALA 135 114. .723 27. .335 24, .135 1. .00 31. .41 1SG1053
ATOM 1053 N ASN 136 115, .967 28. .049 22, .404 1. .00 34, .63 1SG1054
ATOM 1054 CA ASN 136 115, .135 29. .200 22. .188 1. .00 34 , .63 1SG1055
ATOM 1055 CB ASN 136 115, .683 30. .125 21. .088 1. .00 34, .63 1SG1056
ATOM 1056 CG ASN 136 114. .887 31. .423 21. .113 1. .00 34. .63 1SG1057
ATOM 1057 ODl ASN 136 113, .658 31, .419 21, .174 1. .00 34, .63 1SG1058
ATOM 1058 ND2 ASN 136 115, .610 32. .574 21, .071 1. .00 34. .63 1SG1059
ATOM 1059 C ASN 136 113, .777 28. .738 21, .757 1. .00 34. .63 1SG1060
ATOM 1060 O ASN 136 112. ,754 29. .269 22. .185 1. ,00 34. ,63 1SG1061 ATOM 1061 N LEU 137 113.,747 27..710 20.,897 1..00 41..42 1SG1062
ATOM 1062 CA LEU 137 112. ,551 27. .169 20. .325 1. .00 41. .42 1SG1063
ATOM 1063 CB LEU 137 112. ,884 26. .071 19. ,286 1. ,00 41. .42 1SG1064
ATOM 1064 CG LEU 137 111. ,709 25. .420 18. ,520 1. ,00 41. .42 1SG1065
ATOM 1065 CD2 LEU 137 110. .739 24. .658 19. .437 1. .00 41. .42 1SG1066
ATOM 1066 CDl LEU 137 112. .246 24. .494 17. .416 1. .00 41. .42 1SG1067
ATOM 1067 C LEU 137 111. .707 26. .598 21. .429 1. .00 41. .42 1SG1068
ATOM 1068 O LEU 137 110. .482 26. .605 21. ,340 1. ,00 41. .42 1SG1069
ATOM 1069 N SER 138 112. .340 26. .073 22. .495 1. .00 48. .12 1SG1070
ATOM 1070 CA SER 138 111. .645 25. .436 23, .582 1. .00 48. .12 1SG1071
ATOM 1071 CB SER 138 112. .564 24. .676 24. .556 1. .00 48. .12 1SG1072
ATOM 1072 OG SER 138 113. .296 25. .582 25. .366 1. .00 48, .12 1SG1073
ATOM 1073 C SER 138 110. .882 26. .446 24. .379 1. .00 48. .12 1SG1074
ATOM 1074 O SER 138 110. .218 26, .094 25. .352 1. .00 48. .12 1SG1075
ATOM 1075 N THR 139 110. .989 27, .733 24. .012 1. .00 53. .96 1SG1076
ATOM 1076 CA THR 139 110. .284 28, .790 24. .678 1. .00 53. .96 1SG1077
ATOM 1077 CB THR 139 110. .688 30, .155 24. .215 1, .00 53, .96 1SG1078
ATOM 1078 OGl THR 139 112. .077 30, .355 24. .424 1. .00 53, .96 1SG1079
ATOM 1079 CG2 THR 139 109, .885 31, .185 25. .023 1. .00 53, .96 1SG1080
ATOM 1080 C THR 139 108, .827 28, .635 24, .379 1, .00 53, .96 1SG1081
ATOM 1081 O THR 139 107. .975 29, .121 25. .120 1. .00 53, .96 1SG1082
ATOM 1082 N LEU 140 108, .517 27, .982 23. .244 1. .00 57 .39 1SG1083
ATOM 1083 CA LEU 140 107, .177 27, .795 22, .773 1. .00 57, .39 1SG1084
ATOM 1084 CB LEU 140 107, .168 26, .908 21, .510 1. .00 57, .39 1SG1085
ATOM 1085 CG LEU 140 105 .834 26 .828 20 .750 1. .00 57 .39 1SG1086
ATOM 1086 CD2 LEU 140 105, .451 28, .188 20, .147 1, .00 57, .39 1SG1087
ATOM 1087 CDl LEU 140 104. .734 26 .203 21 .612 1. .00 57 .39 1SG1088
ATOM 1088 C LEU 140 106, .392 27, .125 23, .871 1, .00 57, .39 1SG1089
ATOM 1089 O LEU 140 106, .868 26, .182 24, .501 1. .00 57 .39 1SG1090
ATOM 1090 N GLU 141 105 .163 27 .620 24 .151 1 .00 56 .26 1SG1091
ATOM 1091 CA GLU 141 104, .412 27, .072 25, .250 1. .00 56 .26 1SG1092
ATOM 1092 CB GLU 141 103 .278 27 .993 25 .735 1. .00 56 .26 1SG1093
ATOM 1093 CG GLU 141 103, .777 29, .295 26, .367 1, .00 56 .26 1SG1094
ATOM 1094 CD GLU 141 104. .369 28, .973 27, .734 1. .00 56 .26 1SG1095
ATOM 1095 OEl GLU 141 104 .146 27 .833 28 .223 1 .00 56 .26 1SG1096
ATOM 1096 OE2 GLU 141 105, .048 29, .865 28, .308 1. .00 56 .26 1SG1097
ATOM 1097 C GLU 141 103 .798 25 .757 24, .879 1, .00 56 .26 1SG1098
ATOM 1098 O GLU 141 103, .045 25, .663 23, .914 1, .00 56 .26 1SG1099
ATOM 1099 N VAL 142 104, .165 24, .682 25, .610 1, .00 53 .97 1SG1100
ATOM 1100 CA VAL 142 103 .570 23 .385 25, .445 1, .00 53 .97 1SG1101
ATOM 1101 CB VAL 142 104, .450 22, .286 25, .972 1, .00 53 .97 1SG1102
ATOM 1102 CGI VAL 142 105, .666 22 .153 25, .043 1, .00 53 .97 1SG1103
ATOM 1103 CG2 VAL 142 104, .862 22, .629 27, .413 1. .00 53, .97 1SG1104
ATOM 1104 C VAL 142 102, .247 23, .319 26, .145 1, .00 53 .97 1SG1105
ATOM 1105 O VAL 142 101, .223 22 .983 25, .552 1, .00 53 .97 1SG1106
ATOM 1106 N LEU 143 102, .240 23, .663 27, .448 1, .00 50, .32 1SG1107
ATOM 1107 CA LEU 143 101, .032 23 .631 28, .214 1, .00 50 .32 1SG1108
ATOM 1108 CB LEU 143 101, .091 22, .723 29, .456 1, .00 50, .32 1SG1109
ATOM 1109 CG LEU 143 101, .231 21, .227 29, .123 1, .00 50. .32 1SG1110
ATOM 1110 CD2 LEU 143 101, .034 20 .357 30 .374 1 .00 50 .32 1SG1111
ATOM llll CDl LEU 143 102 , .553 20, .940 28, .394 1, .00 50, .32 1SG1112
ATOM 1112 C LEU 143 100, .842 25 .019 28, .699 1, .00 50 .32 1SG1113
ATOM 1113 O LEU 143 101. .503 25, .460 29, .638 1. .00 50, .32 1SG1114
ATOM 1114 N THR 144 99. .909 25, .745 28. .068 1. .00 46, .26 1SG1115
ATOM 1115 CA THR 144 99. .730 27 .104 28. .458 1. .00 46 .26 1SG1116
ATOM 1116 CB THR 144 99. .435 27, .997 27, .291 1. .00 46, .26 1SG1117
ATOM 1117 OGl THR 144 100. .473 27, .892 26, .327 1, .00 46, .26 1SG1118 ATOM 1118 CG2 THR 144 99..326 29..448 27,.790 1..00 46,.26 1SG1119
ATOM 1119 C THR 144 98. .550 27. .143 29. .367 1. .00 46, .26 1SG1120
ATOM 1120 O THR 144 97. .437 26. .807 28. .968 1. .00 46. .26 1SG1121
ATOM 1121 N LYS 145 98. .772 27, .550 30, .632 1. .00 43. .82 1SG1122
ATOM 1122 CA LYS 145 97. .684 27. .602 31. .562 1. .00 43. .82 1SG1123
ATOM 1123 CB LYS 145 98. .114 27. .279 33. .004 1. ,00 43. .82 1SG1124
ATOM 1124 CG LYS 145 96, .973 27. .317 34, .019 1. .00 43. .82 1SG1125
ATOM 1125 CD LYS 145 97. .345 26. .688 35, .362 1. .00 43, .82 1SG1126
ATOM 1126 CE LYS 145 96 .193 26 .673 36, .367 1, .00 43, .82 1SG1127
ATOM 1127 NZ LYS 145 96. .700 26. .334 37, .715 1. .00 43, .82 1SG1128
ATOM 1128 C LYS 145 97, .147 28, .997 31, .518 1. .00 43. .82 1SG1129
ATOM 1129 O LYS 145 97 .826 29 .952 31 .888 1. .00 43 .82 1SG1130
ATOM 1130 N ILE 146 95, .925 29, .142 30, .971 1. .00 42, .56 1SG1131
ATOM 1131 CA ILE 146 95, .264 30, .407 30, .831 1. .00 42, .56 1SG1132
ATOM 1132 CB ILE 146 94, .169 30 .351 29, .806 1, .00 42 .56 1SG1133
ATOM 1133 CG2 ILE 146 94, .827 29, .992 28, .463 1. .00 42, .56 1SG1134
ATOM 1134 CGI ILE 146 93 .067 29 .367 30 .228 1. .00 42 .56 1SG1135
ATOM 1135 CDl ILE 146 91, .832 29 .419 29 .329 1, .00 42 .56 1SG1136
ATOM 1136 C ILE 146 94, .717 30, .923 32, .127 1. .00 42, .56 1SG1137
ATOM 1137 O ILE 146 94 .868 32 .103 32 .439 1. .00 42 .56 1SG1138
ATOM 1138 N ASP 147 94, .036 30 .058 32, .907 1, .00 42 .17 1SG1139
ATOM 1139 CA ASP 147 93, .455 30, .499 34, .142 1. .00 42, .17 1SG1140
ATOM 1140 CB ASP 147 92 .044 31 .098 33 .980 1. .00 42 .17 1SG1141
ATOM 1141 CG ASP 147 91. .098 30 .071 33, .374 1. .00 42, .17 1SG1142
ATOM 1142 ODl ASP 147 91 .524 28 .910 33 .134 1. .00 42 .17 1SG1143
ATOM 1143 OD2 ASP 147 89 .921 30 .451 33 .132 1. .00 42 .17 1SG1144
ATOM 1144 C ASP 147 93. .405 29, .341 35, .083 1. .00 42 .17 1SG1145
ATOM 1145 O ASP 147 94 .093 28 .341 34 .899 1. .00 42 .17 1SG1146
ATOM 1146 N ASN 148 92 .601 29 .461 36, .153 1, .00 42 .41 1SG1147
ATOM 1147 CA ASN 148 92. .536 28, .395 37, .105 1. .00 42 .41 1SG1148
ATOM 1148 CB ASN 148 91 .696 28 .749 38 .346 1, .00 42 .41 1SG1149
ATOM 1149 CG ASN 148 90 .270 29, .059 37, .917 1. .00 42 .41 1SG1150
ATOM 1150 ODl ASN 148 90 .025 29 .512 36 .800 1. .00 42 .41 1SG1151
ATOM 1151 ND2 ASN 148 89 .300 28 .817 38 .840 1. .00 42 .41 1SG1152
ATOM 1152 C ASN 148 91, .959 27, .165 36, .466 1. .00 42 .41 1SG1153
ATOM 1153 O ASN 148 92 .425 26 .059 36 .736 1. .00 42 .41 1SG1154
ATOM 1154 N TYR 149 90 .890 27 .317 35, .656 1. .00 43 .49 1SG1155
ATOM 1155 CA TYR 149 90, .228 26, .185 35, .062 1. .00 43, .49 1SG1156
ATOM 1156 CB TYR 149 88 .818 26 .534 34 .560 1, .00 43 .49 1SG1157
ATOM 1157 CG TYR 149 87 .989 26 .759 35, .775 1. .00 43 .49 1SG1158
ATOM 1158 CDl TYR 149 87 .503 25 .682 36 .479 1, .00 43 .49 1SG1159
ATOM 1159 CD2 TYR 149 87 .694 28 .030 36, .211 1, .00 43, .49 1SG1160
ATOM 1160 CE1 TYR 149 86 .737 25, .865 37, .605 1. .00 43, .49 1SG1161
ATOM 1161 CE2 TYR 149 86 .928 28 .220 37, .338 1, .00 43, .49 1SG1162
ATOM 1162 CZ TYR 149 86. .449 27, .137 38, .036 1. .00 43, .49 1SG1163
ATOM 1163 OH TYR 149 85. .663 27, .329 39, .193 1. .00 43. .49 1SG1164
ATOM 1164 C TYR 149 90 .934 25 .499 33 .922 1. .00 43, .49 1SG1165
ATOM 1165 O TYR 149 91. .200 24, .300 33, .997 1. .00 43, .49 1SG1166
ATOM 1166 N THR 150 91 .300 26 .226 32 .844 1, .00 45, .77 1SG1167
ATOM 1167 CA THR 150 91 .770 25 .487 31, .698 1. .00 45, .77 1SG1168
ATOM 1168 CB THR 150 90. .851 25, .576 30, .512 1. ,00 45, .77 1SG1169
ATOM 1169 OGl THR 150 90 .726 26 .922 30 .078 1. .00 45, .77 1SG1170
ATOM 1170 CG2 THR 150 89. .476 25, .016 30, .916 1. .00 45, .77 1SG1171
ATOM 1171 C THR 150 93. .135 25. .895 31, .245 1. ,00 45. .77 1SG1172
ATOM 1172 O THR 150 93. .712 26, .874 31, .718 1. .00 45. .77 1SG1173
ATOM 1173 N LEU 151 93. . 611 25, .075 30, .310 1. .00 49. .29 1SG1174
ATOM 1174 CA LEU 151 94. .988 25. .201 29, .736 1. .00 49. .29 1SG1175 ATOM 1175 CB LEU 151 95,.959 24..095 30..186 1..00 49..29 1SG1176
ATOM 1176 CG LEU 151 95, .979 23. .849 31, .707 1, .00 49 .29 1SG1177
ATOM 1177 CD2 LEU 151 95 .708 25, .128 32. .508 1. .00 49 .29 1SG1178
ATOM 1178 CDl LEU 151 97, .243 23. .087 32. .138 1, .00 49. .29 1SG1179
ATOM 1179 C LEU 151 94, .847 24. .944 28. .265 1, .00 49. .29 1SG1180
ATOM 1180 O LEU 151 93, .789 24. .538 27, .788 1, .00 49, .29 1SG1181
ATOM 1181 N LEU 152 95, .935 25. .177 27, .504 1 .00 53 .79 1SG1182
ATOM 1182 CA LEU 152 95 .923 24. .906 26, .094 1 .00 53 .79 1SG1183
ATOM 1183 CB LEU 152 96. .295 26. .138 25, .249 1, .00 53, .79 1SG1184
ATOM 1184 CG LEU 152 95, .505 27. .410 25, .604 1, .00 53, .79 1SG1185
ATOM 1185 CD2 LEU 152 94, .008 27. .116 25, .659 1, .00 53 .79 1SG1186
ATOM 1186 CDl LEU 152 95 .857 28. .595 24, .688 1 .00 53 .79 1SG1187
ATOM 1187 C LEU 152 97 .058 23, .947 25, .874 1 .00 53 .79 1SG1188
ATOM 1188 O LEU 152 98 .129 24, .117 26, .457 1 .00 53 .79 1SG1189
ATOM 1189 N ASP 153 96, .857 22. .917 25. .024 1, .00 57, .64 1SG1190
ATOM 1190 CA ASP 153 97, .894 21. .953 24, .764 1, .00 57 .64 1SG1191
ATOM 1191 CB ASP 153 97 .385 20, .501 24, .829 1, .00 57 .64 1SG1192
ATOM 1192 CG ASP 153 98 .576 19. .562 24 .716 1, .00 57 .64 1SG1193
ATOM 1193 ODl ASP 153 99 .719 20, .067 24 .559 1 .00 57 .64 1SG1194
ATOM 1194 OD2 ASP 153 98, .357 18. .323 24, .793 1, .00 57, .64 1SG1195
ATOM 1195 C ASP 153 98, .432 22. .181 23, .380 1, .00 57 .64 1SG1196
ATOM 1196 O ASP 153 97, .861 21. .728 22, .391 1, .00 57 .64 1SG1197
ATOM 1197 N TYR 154 99. .540 22. .940 23, .309 1, .00 59 .66 1SG1198
ATOM 1198 CA TYR 154 100 .342 23, .322 22 .176 1 .00 59 .66 1SG1199
ATOM 1199 CB TYR 154 101, .062 24, .666 22 .319 1 .00 59 .66 1SG1200
ATOM 1200 CG TYR 154 100, .024 25. .719 22, .137 1, .00 59 .66 1SG1201
ATOM 1201 CDl TYR 154 99, .439 25. .890 20, .903 1, .00 59 .66 1SG1202
ATOM 1202 CD2 TYR 154 99, .648 26. .545 23, .170 1 .00 59 .66 1SG1203
ATOM 1203 CE1 TYR 154 98, .483 26. .857 20, .701 1 .00 59 .66 1SG1204
ATOM 1204 CE2 TYR 154 98, .693 27. .515 22 .974 1 .00 59 .66 1SG1205
ATOM 1205 CZ TYR 154 98. .107 27. .672 21. .741 1, .00 59, .66 1SG1206
ATOM 1206 OH TYR 154 97. .128 28. .668 21. .542 1, .00 59 .66 1SG1207
ATOM 1207 C TYR 154 101. .323 22. .277 21, .721 1, .00 59, .66 1SG1208
ATOM 1208 O TYR 154 102, .072 22, .528 20, .781 1, .00 59 .66 1SG1209
ATOM 1209 N SER 155 101, .492 21, .170 22, .468 1, .00 57 .24 1SG1210
ATOM 1210 CA SER 155 102, .510 20, .194 22. .159 1. .00 57, .24 1SG1211
ATOM 1211 CB SER 155 102. .396 18. .910 23. .002 1, .00 57, .24 1SG1212
ATOM 1212 OG SER 155 102. .577 19. .211 24. .378 1, .00 57, .24 1SG1213
ATOM 1213 C SER 155 102, .500 19. .791 20, .712 1, .00 57, .24 1SG1214
ATOM 1214 o SER 155 101, .461 19. .727 20, .059 1, .00 57, .24 1SG1215
ATOM 1215 N LEU 156 103, .710 19. .528 20, .166 1, .00 52, .05 1SG1216
ATOM 1216 CA LEU 156 103. .846 19. .122 18. .794 1, .00 52. .05 1SG1217
ATOM 1217 CB LEU 156 105. .247 19. .374 18. .205 1. .00 52. .05 1SG1218
ATOM 1218 CG LEU 156 105. .596 20. .869 18. .047 1. .00 52. .05 1SG1219
ATOM 1219 CD2 LEU 156 106. .872 21, .055 17. .212 1, .00 52, .05 1SG1220
ATOM 1220 CDl LEU 156 105. .668 21, .587 19, .404 1. .00 52, .05 1SG1221
ATOM 1221 C LEU 156 103. .539 17, .662 18, .688 1, .00 52, .05 1SG1222
ATOM 1222 o LEU 156 103. .991 16. .861 19. .506 1. .00 52. .05 1SG1223
ATOM 1223 N ILE 157 102. .711 17. .299 17. .683 1. .00 46. .22 1SG1224
ATOM 1224 CA ILE 157 102. .334 15. .936 17. .429 1. .00 46. .22 1SG1225
ATOM 1225 CB ILE 157 101. .254 15. .740 16. .406 1. .00 46. .22 1SG1226
ATOM 1226 CG2 ILE 157 100. .995 14. .226 16. .309 1, .00 46. .22 1SG1227
ATOM 1227 CGI ILE 157 100. .001 16. .547 16. ,738 1. .00 46. .22 1SG1228
ATOM 1228 CDl ILE 157 100. .193 18. ,022 16. ,424 1. .00 46. .22 1SG1229
ATOM 1229 C ILE 157 103. .482 15. ,197 16. .841 1. .00 46. .22 1SG1230
ATOM 1230 O ILE 157 103. .693 14. .036 17. .172 1. .00 46. .22 1SG1231
ATOM 1231 N SER 158 104. .212 15. .837 15. .900 1. .00 39. .62 1SG1232 ATOM 1232 CA SER 158 105..268 15..154 15..206 1.,00 39..62 1SG1233
ATOM 1233 CB SER 158 104. .798 14, .555 13. .864 1. .00 39. .62 1SG1234
ATOM 1234 OG SER 158 105. .860 13. .878 13. .207 1. .00 39. .62 1SG1235
ATOM 1235 C SER 158 106. .367 16. .138 14. .921 1. .00 39, .62 1SG1236
ATOM 1236 O SER 158 106. .254 17. .323 15. .228 1. .00 39. .62 1SG1237
ATOM 1237 N SER 159 107. .483 15. .651 14. .336 1. .00 37. .00 1SG1238
ATOM 1238 CA SER 159 108. .619 16. .479 14. .039 1. .00 37. .00 1SG1239
ATOM 1239 CB SER 159 109. .853 15. .678 13. .587 1. .00 37. .00 1SG1240
ATOM 1240 OG SER 159 110. .288 14, .819 14, .631 1. .00 37, .00 1SG1241
ATOM 1241 C SER 159 108. .250 17. .414 12. .932 1. .00 37. .00 1SG1242
ATOM 1242 O SER 159 107. .377 17, .130 12. .113 1. .00 37. .00 1SG1243
ATOM 1243 N PRO 160 108, .904 18, .545 12. .907 1. .00 35. .76 1SG1244
ATOM 1244 CA PRO 160 108, .603 19, .517 11, .895 1. .00 35, .76 1SG1245
ATOM 1245 CD PRO 160 109. .340 19, .174 14, .144 1. .00 35, .76 1SG1246
ATOM 1246 CB PRO 160 109, .265 20, .815 12. .348 1. .00 35, .76 1SG1247
ATOM 1247 CG PRO 160 109. .276 20, .690 13. .883 1. .00 35, .76 1SG1248
ATOM 1248 C PRO 160 109. .006 19, .047 10. .543 1. .00 35, .76 1SG1249
ATOM 1249 O PRO 160 110. .108 18, .524 10. .380 1. .00 35, .76 1SG1250
ATOM 1250 N GLU 161 108, .131 19, .257 9. .547 1. .00 35, .90 1SG1251
ATOM 1251 CA GLU 161 108, .439 18 .788 8. .236 1. .00 35 .90 1SG1252
ATOM 1252 CB GLU 161 107. .244 18, .135 7. .520 1. .00 35, .90 1SG1253
ATOM 1253 CG GLU 161 106, .751 16, .856 8. .199 1. .00 35 .90 1SG1254
ATOM 1254 CD GLU 161 105, .946 17, .259 9, .426 1. .00 35, .90 1SG1255
ATOM 1255 OEl GLU 161 105. .628 18. .472 9. .553 1. .00 35, .90 1SG1256
ATOM 1256 OE2 GLU 161 105, .638 16. .360 10. .253 1. .00 35 .90 1SG1257
ATOM 1257 C GLU 161 108. .855 19, .957 7. .416 1. .00 35, .90 1SG1258
ATOM 1258 O GLU 161 108. .308 21. .053 7, .537 1. .00 35 .90 1SG1259
ATOM 1259 N ILE 162 109. .861 19, .743 6, .552 1. .00 37. .85 1SG1260
ATOM 1260 CA ILE 162 110. .288 20 .795 5. .685 1, .00 37 .85 1SG1261
ATOM 1261 CB ILE 162 111. .780 20, .964 5, .604 1. .00 37 .85 1SG1262
ATOM 1262 CG2 ILE 162 112, .281 21, .367 7, .002 1. .00 37, .85 1SG1263
ATOM 1263 CGI ILE 162 112, .456 19, .700 5, .046 1, .00 37 .85 1SG1264
ATOM 1264 CDl ILE 162 112. .313 18, .476 5, .950 1. .00 37, .85 1SG1265
ATOM 1265 C ILE 162 109. .778 20, .431 4, .331 1, .00 37 .85 1SG1266
ATOM 1266 O ILE 162 109. .972 19. .310 3, .864 1. .00 37, .85 1SG1267
ATOM 1267 N THR 163 109. .057 21. .369 3, .689 1, .00 39 .87 1SG1268
ATOM 1268 CA THR 163 108. .470 21. .097 2, .410 1, .00 39, .87 1SG1269
ATOM 1269 CB THR 163 106, .999 21 .390 2, .359 1. .00 39 .87 1SG1270
ATOM 1270 OGl THR 163 106, .768 22, .777 2, .549 1. .00 39, .87 1SG1271
ATOM 1271 CG2 THR 163 106. .300 20, .583 3. .467 1. .00 39. .87 1SG1272
ATOM 1272 C THR 163 109. .138 21, .949 1, .381 1. .00 39. .87 1SG1273
ATOM 1273 O THR 163 110. .250 22, .435 1, .575 1. .00 39. .87 1SG1274
ATOM 1274 N GLU 164 108. .463 22, .101 0, .224 1. .00 43. .58 1SG1275
ATOM 1275 CA GLU 164 108. .968 22. .870 -0, .874 1. .00 43, .58 1SG1276
ATOM 1276 CB GLU 164 108. .098 22. .742 -2, .136 1, .00 43, .58 1SG1277
ATOM 1277 CG GLU 164 108. .684 23, .454 -3. .358 1. .00 43. .58 1SG1278
ATOM 1278 CD GLU 164 109, .853 22, .624 -3. .868 1, .00 43. .58 1SG1279
ATOM 1279 OEl GLU 164 110. .097 21, .530 -3, .292 1. .00 43, .58 1SG1280
ATOM 1280 OE2 GLU 164 110. .518 23. ,072 -4. .840 1. ,00 43. .58 1SG1281
ATOM 1281 C GLU 164 109. .023 24, .326 -0, .517 1. .00 43. .58 1SG1282
ATOM 1282 O GLU 164 109. .996 25. .001 -0. .847 1. .00 43. .58 1SG1283
ATOM 1283 N ASN 165 107. .979 24. .874 0. .146 1. .00 46. .03 1SG1284
ATOM 1284 CA ASN 165 108. .058 26. .284 0. .414 1. .00 46. .03 1SG1285
ATOM 1285 CB ASN 165 107. .183 27, .118 -0. .538 1. .00 46, .03 1SG1286
ATOM 1286 CG ASN 165 107. .814 27. .069 -1. .922 1. .00 46. .03 1SG1287
ATOM 1287 ODl ASN 165 107. .217 26. .568 -2. .873 1. .00 46. .03 1SG1288
ATOM 1288 ND2 ASN 165 109. .059 27. .605 -2. .040 1. .00 46. .03 1SG1289 ATOM 1289 C ASN 165 107..607 26..608 1..807 1..00 46..03 1SG1290
ATOM 1290 O ASN 165 107. .459 27. .784 2. .140 1. .00 46. .03 1SG1291
ATOM 1291 N TYR 166 107. .369 25. .603 2, .670 1. .00 48. .56 1SG1292
ATOM 1292 CA TYR 166 106. .949 25, .945 3. .998 1. .00 48. .56 1SG1293
ATOM 1293 CB TYR 166 105. ,418 26. .043 4. .132 1. ,00 48. ,56 1SG1294
ATOM 1294 CG TYR 166 104. .819 24. .846 3. .479 1. ,00 48. .56 1SG1295
ATOM 1295 CDl TYR 166 104. .673 23. ,657 4. .152 1. .00 48. .56 1SG1296
ATOM 1296 CD2 TYR 166 104, .401 24, .921 2. .169 1. .00 48. .56 1SG1297
ATOM 1297 CE1 TYR 166 104. .114 22. .567 3, .527 1. .00 48. .56 1SG1298
ATOM 1298 CE2 TYR 166 103. .843 23. .834 1, .540 1. .00 48. .56 1SG1299
ATOM 1299 CZ TYR 166 103. .695 22. .651 2, .222 1. .00 48. .56 1SG1300
ATOM 1300 OH TYR 166 103. .121 21. .529 1, .586 1. .00 48. .56 1SG1301
ATOM 1301 C TYR 166 107. .478 24. .970 5. .003 1, .00 48. .56 1SG1302
ATOM 1302 O TYR 166 107. .749 23. .809 4, .702 1. .00 48. .56 1SG1303
ATOM 1303 N LEU 167 107. .654 25. .450 6. .248 1, .00 48. .11 1SG1304
ATOM 1304 CA LEU 167 108. .061 24, .593 7, .320 1. .00 48. .11 1SG1305
ATOM 1305 CB LEU 167 109. .080 25. .238 8. .269 1. .00 48. .11 1SG1306
ATOM 1306 CG LEU 167 109. .388 24. .364 9, .496 1. .00 48. .11 1SG1307
ATOM 1307 CD2 LEU 167 110. .312 25, .095 10, .477 1. .00 48. .11 1SG1308
ATOM 1308 CDl LEU 167 109, .929 22, ,989 9 .090 1, .00 48, .11 1SG1309
ATOM 1309 C LEU 167 106 , .807 24. .349 8, .096 1. .00 48, .11 1SG1310
ATOM 1310 O LEU 167 106. .211 25. .284 8 .627 1. .00 48. .11 1SG1311
ATOM 1311 N ASP 168 106. .361 23. .079 8, .170 1, .00 45 .48 1SG1312
ATOM 1312 CA ASP 168 105. .112 22. .795 8, .815 1. .00 45, .48 1SG1313
ATOM 1313 CB ASP 168 104. .258 21, .758 8, .066 1. .00 45, .48 1SG1314
ATOM 1314 CG ASP 168 103 , .699 22, .434 6 .825 1, .00 45, .48 1SG1315
ATOM 1315 ODl ASP 168 103 .799 23, .688 6 .747 1. .00 45 .48 1SG1316
ATOM 1316 OD2 ASP 168 103. .155 21. .711 5 .949 1. .00 45, .48 1SG1317
ATOM 1317 C ASP 168 105. .321 22, .276 10, .205 1, .00 45 .48 1SG1318
ATOM 1318 0 ASP 168 106. .147 21. .396 10 .445 1. .00 45 .48 1SG1319
ATOM 1319 N LEU 169 104 .553 22 .835 11 .165 1. .00 44 .76 1SG1320
ATOM 1320 CA LEU 169 104. .606 22. ,404 12, .534 1, .00 44, .76 1SG1321
ATOM 1321 CB LEU 169 105. .044 23. .511 13. .507 1. .00 44, .76 1SG1322
ATOM 1322 CG LEU 169 106. .512 23. .935 13 .324 1 .00 44 .76 1SG1323
ATOM 1323 CD2 LEU 169 106. .964 24 .867 14 .458 1. .00 44, .76 1SG1324
ATOM 1324 CDl LEU 169 106. .759 24. .527 11, .927 1. .00 44, .76 1SG1325
ATOM 1325 C LEU 169 103, .226 21. .967 12 .936 1, .00 44, .76 1SG1326
ATOM 1326 O LEU 169 102, .252 22. .695 12 .744 1 .00 44 .76 1SG1327
ATOM 1327 N ASN 170 103. .114 20, .754 13, .520 1. .00 42. .70 1SG1328
ATOM 1328 CA ASN 170 101. .836 20. .206 13, .898 1. .00 42. .70 1SG1329
ATOM 1329 CB ASN 170 101. .740 18, .692 13 .645 1. .00 42. .70 1SG1330
ATOM 1330 CG ASN 170 102 .167 18, .363 12, .221 1, .00 42 .70 1SG1331
ATOM 1331 ODl ASN 170 102. .841 17, .358 12, .004 1. .00 42. .70 1SG1332
ATOM 1332 ND2 ASN 170 101. .784 19, .210 11, .233 1. .00 42. .70 1SG1333
ATOM 1333 C ASN 170 101. .710 20. .330 15, .392 1. .00 42. .70 1SG1334
ATOM 1334 0 ASN 170 102 .626 19, .961 16, .126 1. .00 42 .70 1SG1335
ATOM 1335 N LEU 171 100. .562 20. .845 15, .888 1. .00 43. .82 1SG1336
ATOM 1336 CA LEU 171 100. .370 20, .987 17. .315 1. .00 43. .82 1SG1337
ATOM 1337 CB LEU 171 100. .375 22. .455 17. .777 1. .00 43 , .82 1SG1338
ATOM 1338 CG LEU 171 101. .701 23. .190 17 .498 1. .00 43. .82 1SG1339
ATOM 1339 CD2 LEU 171 102 , .898 22. .425 18. .086 1. .00 43 , .82 1SG1340
ATOM 1340 CDl LEU 171 101. .649 24. .651 17, .978 1. .00 43. .82 1SG1341
ATOM 1341 C LEU 171 99 .032 20, .394 17, .696 1. .00 43. .82 1SG1342
ATOM 1342 0 LEU 171 98. ,127 20, .325 16. .867 1. ,00 43. .82 1SG1343
ATOM 1343 N LYS 172 98. .889 19. .912 18. .958 1. .00 47 , .21 1SG1344
ATOM 1344 CA LYS 172 97. .661 19. .290 19. .404 1. .00 47. .21 1SG1345
ATOM 1345 CB LYS 172 97. .662 18. .811 20. .870 1. .00 47. .21 1SG1346 ATOM 1346 CG LYS 172 98..468 17.,549 21..166 1.00 47.,21 1SG1347
ATOM 1347 CD LYS 172 99. .970 17. .784 21. .274 1. ,00 47. .21 1SG1348
ATOM 1348 CE LYS 172 100. .763 16. .499 21. .495 1. .00 47. .21 1SG1349
ATOM 1349 NZ LYS 172 100. .498 15. .570 20. .376 1. .00 47. .21 1SG1350
ATOM 1350 C LYS 172 96. .528 20. .271 19. .344 1. .00 47. .21 1SG1351
ATOM 1351 O LYS 172 95. .499 19. .998 18. .730 1. ,00 47. .21 1SG1352
ATOM 1352 N GLY 173 96. .688 21. .449 19. .978 1. ,00 51. .93 1SG1353
ATOM 1353 CA GLY 173 95. .688 22. .482 19. .905 1. .00 51. .93 1SG1354
ATOM 1354 C GLY 173 94. .381 22. .096 20. .535 1. .00 51, .93 1SG1355
ATOM 1355 O GLY 173 93, .341 22. .152 19. .878 1. .00 51, .93 1SG1356
ATOM 1356 N VAL 174 94, .387 21. .690 21. .821 1. .00 59, .33 1SG1357
ATOM 1357 CA VAL 174 93, .152 21. .346 22. .466 1. .00 59, .33 1SG1358
ATOM 1358 CB VAL 174 93. .034 19. .865 22. .707 1. .00 59. .33 1SG1359
ATOM 1359 CGI VAL 174 93, .116 19. .139 21. .360 1. .00 59. .33 1SG1360
ATOM 1360 CG2 VAL 174 94, .157 19. .421 23, .658 1. .00 59, .33 1SG1361
ATOM 1361 C VAL 174 93, .154 21. .992 23, .822 1. .00 59 .33 1SG1362
ATOM 1362 O VAL 174 94, .177 22, .021 24, .505 1. .00 59, .33 1SG1363
ATOM 1363 N PHE 175 91, .998 22, .537 24, .254 1. .00 64 .53 1SG1364
ATOM 1364 CA PHE 175 91. .916 23, .044 25, .594 1. .00 64 .53 1SG1365
ATOM 1365 CB PHE 175 90, .661 23, .885 25, .890 1, .00 64 .53 1SG1366
ATOM 1366 CG PHE 175 90, .853 25, .259 25, .344 1, .00 64 .53 1SG1367
ATOM 1367 CDl PHE 175 90 .914 25 .486 23, .989 1, .00 64 .53 1SG1368
ATOM 1368 CD2 PHE 175 90 .943 26, .333 26, .202 1. .00 64 .53 1SG1369
ATOM 1369 CE1 PHE 175 91. .086 26, .764 23. .505 1. .00 64, .53 1SG1370
ATOM 1370 CE2 PHE 175 91. .111 27. .611 25. .723 1. .00 64, .53 1SG1371
ATOM 1371 CZ PHE 175 91, .187 27, .829 24. .369 1. .00 64, .53 1SG1372
ATOM 1372 C PHE 175 91, .853 21, .822 26, .446 1. .00 64, .53 1SG1373
ATOM 1373 O PHE 175 91, .277 20. .808 26. .056 1. .00 64 .53 1SG1374
ATOM 1374 N TYR 176 92, .472 21. .913 27. .631 1. .00 66 .72 1SG1375
ATOM 1375 CA TYR 176 92, .727 20, .816 28, .516 1. .00 66 .72 1SG1376
ATOM 1376 CB TYR 176 94, .260 20, .700 28, .401 1, .00 66 .72 1SG1377
ATOM 1377 CG TYR 176 95, .069 20, .089 29, .477 1, .00 66 .72 1SG1378
ATOM 1378 CDl TYR 176 95 .124 20, .657 30, .728 1. .00 66 .72 1SG1379
ATOM 1379 CD2 TYR 176 95 .861 19, .005 29, .187 1. .00 66 .72 1SG1380
ATOM 1380 CE1 TYR 176 95, .921 20, .107 31, .702 1, .00 66 .72 1SG1381
ATOM 1381 CE2 TYR 176 96, .660 18, .454 30, .160 1. .00 66 .72 1SG1382
ATOM 1382 CZ TYR 176 96, .688 19, .003 31, .421 1. .00 66 .72 1SG1383
ATOM 1383 OH TYR 176 97, .507 18. .452 32, .429 1, .00 66 .72 1SG1384
ATOM 1384 C TYR 176 92, .278 21, .189 29, .904 1, .00 66 .72 1SG1385
ATOM 1385 0 TYR 176 92, .456 22 .329 30, .324 1. .00 66 .72 1SG1386
ATOM 1386 N PRO 177 91. .570 20, .306 30, .572 1. .00 61 .41 1SG1387
ATOM 1387 CA PRO 177 91 .234 20. .570 31, .958 1, .00 61 .41 1SG1388
ATOM 1388 CD PRO 177 90 .455 19, .697 29. .866 1, .00 61 .41 1SG1389
ATOM 1389 CB PRO 177 89, .819 20, .037 32. .175 1. .00 61 .41 1SG1390
ATOM 1390 CG PRO 177 89 .230 19, .929 30, .761 1. .00 61 .41 1SG1391
ATOM 1391 C PRO 177 92, .192 19. .904 32. .902 1. .00 61, .41 1SG1392
ATOM 1392 0 PRO 177 92, .565 18. .761 32. .639 1. .00 61. .41 1SG1393
ATOM 1393 N LEU 178 92, .584 20. .576 34. .006 1. .00 51, .56 1SG1394
ATOM 1394 CA LEU 178 93, .407 19. .985 35. .029 1. .00 51. .56 1SG1395
ATOM 1395 CB LEU 178 94. .020 21, .025 35. .983 1. .00 51, .56 1SG1396
ATOM 1396 CG LEU 178 95, .009 21, .992 35. .310 1. .00 51. .56 1SG1397
ATOM 1397 CD2 LEU 178 94. .316 22. .841 34. .232 1. .00 51. .56 1SG1398
ATOM 1398 CDl LEU 178 96. .251 21. .249 34. .793 1. .00 51, .56 1SG1399
ATOM 1399 C LEU 178 92. .602 19. .056 35. .890 1. .00 51, .56 1SG1400
ATOM 1400 O LEU 178 93. .043 17. .951 36. .203 1. .00 51, .56 1SG1401
ATOM 1401 N GLU 179 91. .394 19. .493 36. .312 1. .00 42 , .42 1SG1402
ATOM 1402 CA GLU 179 90. .639 18. .708 37. .251 1. .00 42 , .42 1SG1403 ATOM 1403 CB GLU 179 89..318 19,.350 37,.727 1..00 42..42 1SG1404
ATOM 1404 CG GLU 179 89. .456 20. .433 38. .801 1. ,00 42. .42 1SG1405
ATOM 1405 CD GLU 179 89. ,427 21. .801 38. .138 1. ,00 42. .42 1SG1406
ATOM 1406 OEl GLU 179 89. .495 21. .856 36, .882 1. ,00 42. .42 1SG1407
ATOM 1407 OE2 GLU 179 89. .329 22. .811 38. .886 1. ,00 42. .42 1SG1408
ATOM 1408 C GLU 179 90. .253 17, .393 36, .665 1. ,00 42. .42 1SG1409
ATOM 1409 O GLU 179 90. .444 16, .355 37. .296 1. .00 42. .42 1SG1410
ATOM 1410 N ASN 180 89, .696 17, .394 35. .442 1. .00 34. .55 1SG1411
ATOM 1411 CA ASN 180 89. .267 16, .149 34. .876 1. .00 34. .55 1SG1412
ATOM 1412 CB ASN 180 87. .739 15, .964 34. .927 1. .00 34. .55 1SG1413
ATOM 1413 CG ASN 180 87. .383 14, .559 34. .457 1. .00 34. .55 1SG1414
ATOM 1414 ODl ASN 180 88. .246 13, .705 34, .257 1. .00 34. .55 1SG1415
ATOM 1415 ND2 ASN 180 86. .060 14, .312 34. .266 1. .00 34. .55 1SG1416
ATOM 1416 C ASN 180 89, .659 16, .150 33 .437 1. .00 34. .55 1SG1417
ATOM 1417 O ASN 180 89, .568 17, .173 32. .761 1. .00 34. .55 1SG1418
ATOM 1418 N LEU 181 90. .105 14, .987 32. .926 1. .00 35. .44 1SG1419
ATOM 1419 CA LEU 181 90. .511 14, .918 31. .555 1. .00 35. .44 1SG1420
ATOM 1420 CB LEU 181 91. .767 14, .057 31. .338 1. .00 35. .44 1SG1421
ATOM 1421 CG LEU 181 93, .008 14, .559 32 .097 1. .00 35, .44 1SG1422
ATOM 1422 CD2 LEU 181 93. .284 16, .040 31. .801 1. .00 35. .44 1SG1423
ATOM 1423 CDl LEU 181 94, .224 13 .657 31 .830 1. .00 35, .44 1SG1424
ATOM 1424 C LEU 181 89, .410 14, .248 30, .797 1. .00 35. .44 1SG1425
ATOM 1425 O LEU 181 89. .002 13 .140 31 .140 1. .00 35, .44 1SG1426
ATOM 1426 N THR 182 88. .884 14, .917 29, .751 1. .00 41, .87 1SG1427
ATOM 1427 CA THR 182 87 .859 14 .306 28 .953 1, .00 41, .87 1SG1428
ATOM 1428 CB THR 182 86. .487 14 .858 29, .214 1. .00 41, .87 1SG1429
ATOM 1429 OGl THR 182 86 .445 16 .239 28 .885 1, .00 41, .87 1SG1430
ATOM 1430 CG2 THR 182 86. .139 14, .652 30 .698 1. .00 41, .87 1SG1431
ATOM 1431 C THR 182 88, .179 14, .589 27 .515 1. .00 41, .87 1SG1432
ATOM 1432 O THR 182 88 .528 15 .714 27 .161 1. .00 41, .87 1SG1433
ATOM 1433 N ASP 183 88, .078 13, .563 26, .646 1. .00 59, .91 1SG1434
ATOM 1434 CA ASP 183 88, .366 13 .755 25 .250 1. .00 59, .91 1SG1435
ATOM 1435 CB ASP 183 88, .731 12, .453 24, .515 1. .00 59, .91 1SG1436
ATOM 1436 CG ASP 183 90, .071 11 .979 25 .057 1. .00 59, .91 1SG1437
ATOM 1437 ODl ASP 183 90, .395 12, .341 26, .219 1. .00 59, .91 1SG1438
ATOM 1438 OD2 ASP 183 90 .793 11 .262 24 .313 1. .00 59, .91 1SG1439
ATOM 1439 C ASP 183 87, .146 14, .323 24, .586 1. .00 59, .91 1SG1440
ATOM 1440 O ASP 183 86 .022 13 .994 24 .961 1. .00 59, .91 1SG1441
ATOM 1441 N PRO 184 87, .326 15, .189 23, .618" 1. .00 78, .98 1SG1442
ATOM 1442 CA PRO 184 86 .244 15 .784 22 .878 1. .00 78, .98 1SG1443
ATOM 1443 CD PRO 184 88, .630 15, .626 23 .159 1. .00 78, .98 1SG1444
ATOM 1444 CB PRO 184 86 .880 16 .882 22 .035 1, .00 78, .98 1SG1445
ATOM 1445 CG PRO 184 88, .326 16 .388 21 .861 1. .00 78. .98 1SG1446
ATOM 1446 C PRO 184 85, .616 14, .748 22, .008 1. .00 78. .98 1SG1447
ATOM 1447 O PRO 184 86, .375 13, .953 21, .456 1. .00 78. .98 1SG1448
ATOM 1448 N PRO 185 84, .320 14, .653 21, .866 1. ,00 91. .73 1SG1449
ATOM 1449 CA PRO 185 83 .848 13 .739 20, .874 1. .00 91. .73 1SG1450
ATOM 1450 CD PRO 185 83, .364 14. .851 22, .938 1. .00 91. .73 1SG1451
ATOM 1451 CB PRO 185 82 .393 13 .428 21 .230 1. .00 91. .73 1SG1452
ATOM 1452 CG PRO 185 82. .020 14. .493 22, .281 1. .00 91. .73 1SG1453
ATOM 1453 C PRO 185 84 .057 14 .435 19 .577 1. .00 91, .73 1SG1454
ATOM 1454 0 PRO 185 83. .119 15. .074 19, .104 1. ,00 91. .73 1SG1455
ATOM 1455 N PHE 186 85 .247 14 .295 18, .964 1. .00 99. .60 1SG1456
ATOM 1456 CA PHE 186 85. .516 15. .026 17, .762 1. .00 99. .60 1SG1457
ATOM 1457 CB PHE 186 85 .772 16 .526 17, .972 1. .00 99, .60 1SG1458
ATOM 1458 CG PHE 186 84. .430 17. .370 18. .318 1. ,00 99. .60 1SG1459
ATOM 1459 CDl PHE 186 83 .460 17 .936 19. .213 1. .00 99. .60 1SG1460 p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H P O O P P P O P P P P P P O O O O O P P P P P O P P O P O O O O P P O P O O O O P P P P P O P P O P P P P O P P P 3 3 3 3 3 3 3 2 2 2 2 2 2 2 22 2 2 2 2 2 22 2 22 3 33 2 22 3 2 2 2 32 3 22 2 2 22 2 3 3 3 3 3 3 2 2 23 2
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Ω Ω Ω Ω Ω 3 P Ω Ω Ω Ω Ω Ω Ω Ω Ω 3 P Ω Ω Ω Ω Ω 3 P Ω Ω Ω Ω Ω 3 0 Ω Ω Ω Ω Ω 3 O Ω P Ω Ω O Ω Ω Ω Ω Ω d d Ω 03 p a o Ω Ω Ω Ω Ω Ω Ω ro P N B B O O Q B > Ω 03 d P Ω Ω CO P Ω CO d P Ω ro P N B B D H to to H to H to H to H ts) H tO
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C C C C C a P . E' t' t' r' B B B H B B W B W B B OO OO O OO ' t't' t' rP t' OO OO O O OIv iO SM i. S B B B B M B H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H ιo vo vo vo vo vo o vo ιo vo vo vo vo ιo ιo vo vo ιo vo vo vo ιo vo ιo ιo ιo ιo ιo VD io ιo CD CD CD cσ e» eD CD e» eD CD CD CD ω
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lO VD VD VO VD lD VO lD VD VO VO VO lD VO VO VD VO VO VO lO VO VD VO VO VD VO VO VO VO VD VD VO VD rø eD CO CD CD VO lO Vn vO VO VO OO CO OO OO OO OT sι cn cn ιn uι uι uJ 4* 4* ιn 4* 4* UJ in 4* en cn cn ιn ιn 4* ω uJ UJ H to H to o M H H H s c» co vo vo o o H H θ o vo si oo oo CD θθ sα s cn uι to uj UJ iD 4* cn ^ uJ ui 4* _i CD en en cD VD Ui uJ io uJ ui H Ul H ui ui σi ui H Ui ui ui to io o ui iO si ai si uJ o vo 4* si H CD si cn w ui it* H sl 00 sl sl Ul Ul _i si t H H to co en uj e» _5 si cn cD iD 4* uι uι UJ H VD 4* 4* tO OO sl 4* UJ Oo σi H UJ H CO r sl o σi 4* Ul H sl sl OO VD t σ -J H θ VD 4* sj oo H H cn σi 4* oo ιo vo o to H tO 4* VD tO Ul H 4* sl O O t OO O Cn o ui H it* VD 4* ui ID oo en 4* H to sl
4* tO tO tO CO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO tO H H H H H H H H H H H H H H H H H H H H H H H H H H H H H si si en si en 4* 4* uι o H H W co to co 4* en uJ 4* co uJ UJ H o o ιo en si s] oo co iD eD io iD i_ι oo oo oi s] φ. it* 4* s] 00 sl o 4* si o o _ι θ si o oo 4* uj H H θ U o to uι oo 4* o oo uι θ si si co o uJ H UJ si 4* ιn en σi si uι en uJ 4* 4* oo σι U H o uι cD to σi H θθ si co ιi* en si si H θJ cn uι co ι^ ui si θD UJ ui s] θ 4* si cD θo H θ σι ιt* 4* sJ si to to oo ui H uι to o s vD H vD to vo to uι en u) VD Vo to σ si cn cD θ uι t uJ θo vo co ui H 4* sι σι oo ui s] uι to eD H cn H si σi 4* o en en en cn 4* 4* si uι θ si H uι
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O O O O O O O O O VVDD IIOO VD VO VO VO VD VO VVDD IVDD VVDD VVOO VVOO VVDD VVOO VVOO IIDD VVDD VVDD VVDD VVDD VVDD VVDD VVDD VVDD IIDD VVDD VVDD VVDD VO VO VD VD VO VO VO ID VD VO VO VO IO IO VO VO VO IO VO VO O O O O O O o o vD Vo iD VD vo io oo co ∞oo CoDo θooo αooo eooo coDo ssi ssii ssii ssii ssii ssii oonn oonn oonn eenn ccnn σcnι ccnn ccnn eenn en cn uι uι uι uι σι uι uι uι ui 4* 4* 4* 4* 4* 4* 4* UJ Uι
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4* UJ U ω ω ui uJ UJ UJ UJ ω ω ω uj ω uJ UJ UJ UJ Ui uj u UJ ω uj ω ω ui uJ ui ui ui uJ UJ UJ UJ UJ UJ ω uJ to to to to to to to to to to to to to to to w co uJ io si s] in ιn cn ι^ cn en cn co s] io vD oo s] s uι en ιn uJ 4* 4* uJ to to uι uι uι uJ UJ to tθ H o ιo vo cn ιn en si si oo si ιo co iD θθ si si s] in cn
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4* ι^ ι^ ιt* ιt* 4* 4* 4* ι^ 4* ιt* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* 4* o o o o o o o o to to to to to to 4* ιt> ιt> 4* 4* 4* 4* 4* uι uι uι uι uι ui -i -i -i -i -i -i en cn -i cn -i uι uι uι uι uι uι uι uι uι uι uι uι uι uι uι uι σι cn oi σi o oi oi oi σi σi H H H H H VO VO VD VD VD VO VO V0 4* 4* 4* 4* 4* 4* ID VD ID VO VO VO VO VO VO VO VO U) UJ UJ U1 UJ UI U1 UI UJ 0 0 0 0 0 0 0 4* 4*
H H H H H H H H O O O O O CD OD Oo oo oo oo oo oo vo vo vD VD Vo vD Oi oi oi cn cn en cn cn en cn cn ui ui ui ui ui ui uJ ui ui in ui ui ui ui ui ui en σi
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H to to to to to to to to to to to to to to m to to to to to to to to to m to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to to
Ω Ω Ώ Ω Ω Ω Ω Ω Ώ Ώ Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ Ώ Ω Ω Ώ Ω Ω Ώ Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ώ Ω Ω Ω Ω Ω Ω Ω Ώ Ω Ω Ω Ώ Ώ Ω Ω Ώ
H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H
-l ui ui ui ui ui ui ui ui ui ui -i ui m ui ui ui ui ui ui ui ui ui ui ui -i -i ui ui ui ui ui ui ui ui ui ui ui ui ui ui si si si si s en cn cn σi cn cn cn cn cn tn ui ui ui ui ui ui ui ui ui
4* uι tθ H θ vD θθ sj en uι 4* uJ tθ H o iD oo si σι ui 4* UJ to si cn uι 4* uJ tθ H θ io oo
ATOM 1574 N LEU 201 104..335 33..973 9.,211 1.,00 38..71 1SG1575
ATOM 1575 CA LEU 201 103. ,834 32. .726 9. ,735 1. ,00 38. .71 1SG1576
ATOM 1576 CB LEU 201 104. ,097 32. .546 11. ,239 1. ,00 38. .71 1SG1577
ATOM 1577 CG LEU 201 105. .595 32, .492 11. .591 1. .00 38. .71 1SG1578
ATOM 1578 CD2 LEU 201 105. .812 32, .052 13. .047 1. .00 38. ,71 1SG1579
ATOM 1579 CDl LEU 201 106. .290 33. .822 11. .258 1. .00 38. .71 1SG1580
ATOM 1580 C LEU 201 102. .351 32. .649 9. .538 1. .00 38. .71 1SG1581
ATOM 1581 O LEU 201 101. . 611 33 .670 9, .416 1. .00 38. .71 1SG1582
ATOM 1582 N TYR 202 101. .812 31. .409 9. .477 1. .00 37. .32 1SG1583
ATOM 1583 CA TYR 202 100. .399 31, .208 9. .313 1. .00 37. .32 1SG1584
ATOM 1584 CB TYR 202 100. .000 30, .649 7. .933 1. .00 37. .32 1SG1585
ATOM 1585 CG TYR 202 100. .293 31 .652 6. .869 1. .00 37. .32 1SG1586
ATOM 1586 CDl TYR 202 101. .543 31, .733 6. .299 1, .00 37. .32 1SG1587
ATOM 1587 CD2 TYR 202 99. .308 32, .509 6. .432 1. .00 37. .32 1SG1588
ATOM 1588 CE1 TYR 202 101. .806 32, .656 5. .313 1. .00 37. .32 1SG1589
ATOM 1589 CE2 TYR 202 99. .566 33 .434 5. .447 1, .00 37. .32 1SG1590
ATOM 1590 CZ TYR 202 100. .817 33 .508 4. .886 1. .00 37. .32 1SG1591
ATOM 1591 OH TYR 202 101. .086 34, .455 3. .875 1. .00 37. .32 1SG1592
ATOM 1592 C TYR 202 99. .956 30, .177 10. .307 1 , .00 37. .32 1SG1593
ATOM 1593 O TYR 202 100, .626 29 .165 10, .506 1 .00 37. .32 1SG1594
ATOM 1594 N ILE 203 98. .796 30 .402 10, .958 1. .00 36. .41 1SG1595
ATOM 1595 CA ILE 203 98. .310 29 .427 11, .889 1. .00 36, .41 1SG1596
ATOM 1596 CB ILE 203 98. .230 29, .907 13, .311 1, .00 36. .41 1SG1597
ATOM 1597 CG2 ILE 203 99. .652 30 .243 13 .789 1 .00 36. .41 1SG1598
ATOM 1598 CGI ILE 203 97, .241 31 .073 13 .427 1. .00 36. .41 1SG1599
ATOM 1599 CDl ILE 203 96, .884 31 .447 14. .865 1. .00 36. .41 1SG1600
ATOM 1600 C ILE 203 96. .933 29 .039 11, .466 1. .00 36. .41 1SG1601
ATOM 1601 O ILE 203 96. .140 29 .872 11, .029 1. .00 36. .41 1SG1602
ATOM 1602 N GLY 204 96, .626 27 .733 11 .569 1 .00 34. .93 1SG1603
ATOM 1603 CA GLY 204 95, .316 27 .276 11 .225 1. .00 34. .93 1SG1604
ATOM 1604 C GLY 204 94. .695 26 .830 12, .503 1. .00 34. .93 1SG1605
ATOM 1605 O GLY 204 95. .038 25, .772 13, .030 1. .00 34 , .93 1SG1606
ATOM 1606 N ILE 205 93, .739 27 .632 13 .016 1 .00 39. .74 1SG1607
ATOM 1607 CA ILE 205 93 , .101 27 .305 14 .256 1, .00 39. .74 1SG1608
ATOM 1608 CB ILE 205 92. .894 28 .500 15, .159 1. .00 39, .74 1SG1609
ATOM 1609 CG2 ILE 205 94. .274 29, .018 15, .591 1, .00 39. .74 1SG1610
ATOM 1610 CGI ILE 205 92. .037 29 .582 14 .486 1 .00 39 .74 1SG1611
ATOM 1611 CDl ILE 205 91. .809 30 .801 15 .381 1 .00 39, .74 1SG1612
ATOM 1612 C ILE 205 91. .791 26 .662 13 .939 1, .00 39, .74 1SG1613
ATOM 1613 O ILE 205 90. .835 27, .312 13, .522 1, .00 39. .74 1SG1614
ATOM 1614 N ALA 206 91. .732 25 .334 14 .152 1 .00 45. .18 1SG1615
ATOM 1615 CA ALA 206 90. .591 24 .538 13 .807 1 .00 45, .18 1SG1616
ATOM 1616 CB ALA 206 90, .857 23 .024 13 .856 1, .00 45. .18 1SG1617
ATOM 1617 C ALA 206 89, .448 24, .818 14, .728 1, .00 45. .18 1SG1618
ATOM 1618 O ALA 206 89, .611 25 .371 15 .814 1 .00 45. .18 1SG1619
ATOM 1619 N GLU 207 88. .237 24 .437 14 .273 1 .00 54, .14 1SG1620
ATOM 1620 CA GLU 207 87. .023 24 .613 15 .015 1, .00 54, .14 1SG1621
ATOM 1621 CB GLU 207 85. .768 24, .156 14, .248 1, .00 54. .14 1SG1622
ATOM 1622 CG GLU 207 85, .793 22 .676 13 .855 1 .00 54. .14 1SG1623
ATOM 1623 CD GLU 207 84, .369 22 .239 13 .531 1 .00 54. .14 1SG1624
ATOM 1624 OEl GLU 207 83. .618 21 .940 14 .498 1, .00 54. .14 1SG1625
ATOM 1625 OE2 GLU 207 84. .009 22 .198 12, .324 1, .00 54. .14 1SG1626
ATOM 1626 C GLU 207 87, .126 23 .774 16 .242 1 .00 54. .14 1SG1627
ATOM 1627 O GLU 207 86, .615 24 .120 17 .305 1, .00 54. .14 1SG1628
ATOM 1628 N TYR 208 87. .813 22 .632 16 .108 1, .00 64. .36 1SG1629
ATOM 1629 CA TYR 208 87. .992 21, .691 17, .167 1, .00 64. .36 1SG1630
ATOM 1630 CB TYR 208 88. .806 20 .506 16 .642 1, .00 64. .36 1SG1631 ATOM 1631 CG TYR 208 89,.286 19,.683 17..768 1,.00 64,.36 1SG1632
ATOM 1632 CDl TYR 208 88, .525 18, .671 18. .304 1, .00 64, .36 1SG1633
ATOM 1633 CD2 TYR 208 90, .525 19, .954 18, .281 1, .00 64, .36 1SG1634
ATOM 1634 CE1 TYR 208 89, .016 17, .924 19, .347 1, .00 64, .36 1SG1635
ATOM 1635 CE2 TYR 208 91, .013 19, .211 19, .316 1, .00 64, .36 1SG1636
ATOM 1636 CZ TYR 208 90 .267 18 .196 19, .851 1 .00 64 .36 1SG1637
ATOM 1637 OH TYR 208 90 .808 17 .450 20 .918 1 .00 64 .36 1SG1638
ATOM 1638 C TYR 208 88 .685 22 .396 18, .293 1 .00 64 .36 1SG1639
ATOM 1639 O TYR 208 88 .324 22 .232 19. .458 1 .00 64 .36 1SG1640
ATOM 1640 N PHE 209 89 .678 23 .237 17 .955 1 .00 65 .14 1SG1641
ATOM 1641 CA PHE 209 90 .439 23 .990 18. .911 1 .00 65 .14 1SG1642
ATOM 1642 CB PHE 209 91 .356 24 .982 18, .172 1, .00 65 .14 1SG1643
ATOM 1643 CG PHE 209 92 .299 25 .677 19, .094 1, .00 65, .14 1SG1644
ATOM 1644 CDl PHE 209 91, .864 26 .523 20, .089 1, .00 65 .14 1SG1645
ATOM 1645 CD2 PHE 209 93, .650 25. .513 18, .912 1, .00 65, .14 1SG1646
ATOM 1646 CE1 PHE 209 92, .767 27, .160 20. .909 1. .00 65, .14 1SG1647
ATOM 1647 CE2 PHE 209 94, .554 26, .149 19. .726 1, .00 65, .14 1SG1648
ATOM 1648 CZ PHE 209 94 .115 26 .973 20 .730 1 .00 65 .14 1SG1649
ATOM 1649 C PHE 209 89 .476 24 .825 19 .705 1 .00 65 .14 1SG1650
ATOM 1650 O PHE 209 89 .469 24 .798 20. .934 1, .00 65 .14 1SG1651
ATOM 1651 N PHE 210 88 .613 25 .579 19. .003 1 .00 61 .79 1SG1652
ATOM 1652 CA PHE 210 87 .678 26 .476 19, .628 1, .00 61 .79 1SG1653
ATOM 1653 CB PHE 210 86 .843 27 .270 18, .607 1, .00 61, .79 1SG1654
ATOM 1654 CG PHE 210 87, .679 28 .274 17, .887 1, .00 61, .79 1SG1655
ATOM 1655 CDl PHE 210 88 .487 27, .916 16. .832 1, .00 61, .79 1SG1656
ATOM 1656 CD2 PHE 210 87, .629 29, .596 18, .258 1, .00 61, .79 1SG1657
ATOM 1657 CE1 PHE 210 89, .240 28, .861 16. .174 1, .00 61, .79 1SG1658
ATOM 1658 CE2 PHE 210 88, .377 30, .546 17. .604 1, .00 61, .79 1SG1659
ATOM 1659 CZ PHE 210 89 .185 30 .178 16. .560 1 .00 61 .79 1SG1660
ATOM 1660 C PHE 210 86 .675 25 .716 20. .447 1, .00 61 .79 1SG1661
ATOM 1661 O PHE 210 86 .309 26 .134 21. .544 1 .00 61 .79 1SG1662
ATOM 1662 N LYS 211 86, .183 24 .588 19, .903 1, .00 53 .50 1SG1663
ATOM 1663 CA LYS 211 85, .143 23, .791 20, .497 1, .00 53 .50 1SG1664
ATOM 1664 CB LYS 211 84, .838 22, .526 19, .679 1, .00 53 .50 1SG1665
ATOM 1665 CG LYS 211 83, .498 21, .874 20, .013 1, .00 53, .50 1SG1666
ATOM 1666 CD LYS 211 82, .349 22, .545 19. .269 1. .00 53, .50 1SG1667
ATOM 1667 CE LYS 211 82. .408 22, .242 17. .771 1, .00 53, .50 1SG1668
ATOM 1668 NZ LYS 211 81. .679 23. .273 17. .008 1. .00 53, .50 1SG1669
ATOM 1669 C LYS 211 85. .599 23, .261 21. .816 1. .00 53, .50 1SG1670
ATOM 1670 O LYS 211 84. .817 23 .183 22. .762 1. .00 53, .50 1SG1671
ATOM 1671 N SER 212 86, .877 22 .854 21. .903 1, .00 41, .94 1SG1672
ATOM 1672 CA SER 212 87, .368 22, .236 23. .099 1. .00 41, .94 1SG1673
ATOM 1673 CB SER 212 88, .840 21. .806 22. .989 1, .00 41, .94 1SG1674
ATOM 1674 OG SER 212 89, .668 22. .950 22. .848 1. .00 41. .94 1SG1675
ATOM 1675 C SER 212 87, .274 23. .211 24. .225 1. .00 41. .94 1SG1676
ATOM 1676 O SER 212 87, .085 22. .822 25. .376 1. .00 41. .94 1SG1677
ATOM 1677 N ALA 213 87. .416 24. .513 23. .926 1. .00 34. .46 1SG1678
ATOM 1678 CA ALA 213 87. .358 25. .493 24. ,969 1. .00 34. .46 1SG1679
ATOM 1679 CB ALA 213 87. .593 26. .923 24. ,453 1. .00 34. .46 1SG1680
ATOM 1680 C ALA 213 85. .997 25. .459 25. ,586 1. ,00 34. .46 1SG1681
ATOM 1681 O ALA 213 85. ,850 25. ,489 26. .807 1. ,00 34. .46 1SG1682
ATOM 1682 N SER 214 84. .960 25. .374 24. .739 1. .00 30. .43 1SG1683
ATOM 1683 CA SER 214 83. .601 25. .404 25. .183 1. .00 30. ,43 1SG1684
ATOM 1684 CB SER 214 82. .629 25. .291 24. ,004 1. .00 30. .43 1SG1685
ATOM 1685 OG SER 214 81. .296 25. .299 24. ,481 1. .00 30. ,43 1SG1686
ATOM 1686 C SER 214 83. .329 24. .245 26. .083 1. .00 30. ,43 1SG1687
ATOM 1687 O SER 214 82. .688 24. .392 27. 123 1. 00 30. ,43 1SG1688 ATOM 1688 N PHE 215 83..806 23..054 25..686 1.,00 29..17 1SG1689
ATOM 1689 CA PHE 215 83, .524 21. .854 26. .412 1. .00 29. .17 1SG1690
ATOM 1690 CB PHE 215 84. .047 20. .601 25. .690 1. .00 29. .17 1SG1691
ATOM 1691 CG PHE 215 83. .301 19. .431 26. .232 1. .00 29. .17 1SG1692
ATOM 1692 CDl PHE 215 82, .062 19. .124 25. .718 1. .00 29. .17 1SG1693
ATOM 1693 CD2 PHE 215 83, .821 18, .645 27, .234 1. .00 29. .17 1SG1694
ATOM 1694 CE1 PHE 215 81. .346 18, .051 26, .194 1. .00 29. .17 1SG1695
ATOM 1695 CE2 PHE 215 83. .108 17. .570 27, .714 1. .00 29. .17 1SG1696
ATOM 1696 CZ PHE 215 81. .871 17. .272 27, .195 1. .00 29. .17 1SG1697
ATOM 1697 C PHE 215 84. .174 21. .919 27, .762 1. .00 29. .17 1SG1698
ATOM 1698 O PHE 215 83. .553 21. .587 28, .770 1. .00 29. .17 1SG1699
ATOM 1699 N ALA 216 85, .447 22, .357 27, .812 1. .00 31, .08 1SG1700
ATOM 1700 CA ALA 216 86, .192 22, .381 29, .039 1. .00 31. .08 1SG1701
ATOM 1701 CB ALA 216 87. .642 22. .856 28, .839 1. .00 31. .08 1SG1702
ATOM 1702 C ALA 216 85. .552 23. .305 30, .028 1. .00 31. .08 1SG1703
ATOM 1703 O ALA 216 85. .440 22. .977 31 .208 1. .00 31. .08 1SG1704
ATOM 1704 N HIS 217 85. .124 24, .496 29, .578 1. .00 33, .70 1SG1705
ATOM 1705 CA HIS 217 84. .537 25. .458 30, .469 1. .00 33. .70 1SG1706
ATOM 1706 NDl HIS 217 85. .660 28. .683 28 .718 1. .00 33. .70 1SG1707
ATOM 1707 CG HIS 217 85. .586 27, .530 29 .468 1, .00 33. .70 1SG1708
ATOM 1708 CB HIS 217 84. .306 26, .825 29, .806 1. .00 33. .70 1SG1709
ATOM 1709 NE2 HIS 217 87, .746 28, .155 29 .279 1. .00 33, .70 1SG1710
ATOM 1710 CD2 HIS 217 86, .869 27, .222 29 .802 1, .00 33, .70 1SG1711
ATOM 1711 CE1 HIS 217 86, .974 29, .013 28, .636 1, .00 33, .70 1SG1712
ATOM 1712 C HIS 217 83. .215 24. .962 30, .983 1. .00 33, .70 1SG1713
ATOM 1713 O HIS 217 82. .872 25. .184 32 .143 1, .00 33, .70 1SG1714
ATOM 1714 N PHE 218 82, .420 24, .306 30, .117 1. .00 35, .37 1SG1715
ATOM 1715 CA PHE 218 81. .104 23, .833 30, .464 1. .00 35, .37 1SG1716
ATOM 1716 CB PHE 218 80 .402 23, .216 29 .237 1, .00 35, .37 1SG1717
ATOM 1717 CG PHE 218 79, .109 22, .589 29 .638 1, .00 35, .37 1SG1718
ATOM 1718 CDl PHE 218 79. .074 21, ,286 30, .084 1, .00 35, .37 1SG1719
ATOM 1719 CD2 PHE 218 77, .931 23 , .292 29, .555 1. .00 35, .37 1SG1720
ATOM 1720 CE1 PHE 218 77, .889 20, .696 30 .452 1, .00 35, .37 1SG1721
ATOM 1721 CE2 PHE 218 76, .742 22, .706 29 .921 1, .00 35, .37 1SG1722
ATOM 1722 CZ PHE 218 76, .717 21, .408 30, .371 1. .00 35, .37 1SG1723
ATOM 1723 C PHE 218 81, .162 22, .776 31 .530 1, .00 35, .37 1SG1724
ATOM 1724 O PHE 218 80, .491 22, .875 32 .556 1, .00 35, .37 1SG1725
ATOM 1725 N THR 219 82, .005 21, .748 31, .323 1. .00 36, .11 1SG1726
ATOM 1726 CA THR 219 82. .082 20, .605 32, .190 1. .00 36. .11 1SG1727
ATOM 1727 CB THR 219 83, .074 19, .586 31, .716 1. .00 36. .11 1SG1728
ATOM 1728 OGl THR 219 84, .379 20, .146 31, .691 1. .00 36. .11 1SG1729
ATOM 1729 CG2 THR 219 82. .667 19, .122 30, .307 1. .00 36. .11 1SG1730
ATOM 1730 C THR 219 82. .502 21, .034 33 .558 1. .00 36, .11 1SG1731
ATOM 1731 O THR 219 82, .128 20, .416 34, .554 1. .00 36. .11 1SG1732
ATOM 1732 N ALA 220 83, .321 22. .093 33, .633 1. .00 35. .24 1SG1733
ATOM 1733 CA ALA 220 83. .812 22. .608 34. .877 1. ,00 35. .24 1SG1734
ATOM 1734 CB ALA 220 84. .754 23. .810 34. .693 1. .00 35. .24 1SG1735
ATOM 1735 C ALA 220 82. .646 23. .058 35, .702 1. .00 35. .24 1SG1736
ATOM 1736 O ALA 220 82. .677 22. .960 36. .926 1. ,00 35. .24 1SG1737
ATOM 1737 N GLY 221 81, .583 23, .579 35. .060 1. .00 34. .36 1SG1738
ATOM 1738 CA GLY 221 80. .446 24. .045 35, .805 1. .00 34. .36 1SG1739
ATOM 1739 C GLY 221 80. .616 25. .515 36. .017 1. .00 34. .36 1SG1740
ATOM 1740 O GLY 221 79. .945 26. .119 36. .852 1. .00 34. .36 1SG1741
ATOM 1741 N VAL 222 81. .576 26. .103 35. .282 1. .00 35. .23 1SG1742
ATOM 1742 CA VAL 222 81. .909 27. .498 35. .327 1. .00 35. .23 1SG1743
ATOM 1743 CB VAL 222 83. ,189 27. .788 34. .602 1. .00 35. .23 1SG1744
ATOM 1744 CGI VAL 222 83. .417 29. .307 34. .598 1. .00 35. .23 1SG1745 ATOM 1745 CG2 VAL 222 84,.323 26,.984 35..260 1..00 35,.23 1SG1746
ATOM 1746 C VAL 222 80. .857 28. .362 34. .705 1. .00 35. .23 1SG1747
ATOM 1747 O VAL 222 80. .550 29, .423 35, .243 1. .00 35. .23 1SG1748
ATOM 1748 N PHE 223 80. .283 27, .959 33, .549 1. .00 36. .83 1SG1749
ATOM 1749 CA PHE 223 79, .364 28. .862 32. .912 1. .00 36. .83 1SG1750
ATOM 1750 CB PHE 223 79, .115 28. .591 31 .418 1, .00 36. .83 1SG1751
ATOM 1751 CG PHE 223 80, .249 29, .206 30. .672 1. .00 36. .83 1SG1752
ATOM 1752 CDl PHE 223 81, .428 28, .528 30. .470 1, .00 36. .83 1SG1753
ATOM 1753 CD2 PHE 223 80. .123 30. .485 30, .180 1. ,00 36. .83 1SG1754
ATOM 1754 CE1 PHE 223 82, .460 29. .122 29, .780 1. .00 36. .83 1SG1755
ATOM 1755 CE2 PHE 223 81, .151 31, .082 29, .490 1. .00 36, .83 1SG1756
ATOM 1756 CZ PHE 223 82, .324 30. .398 29, .289 1. .00 36. .83 1SG1757
ATOM 1757 C PHE 223 78, .054 28. .865 33, .616 1, .00 36, .83 1SG1758
ATOM 1758 O PHE 223 77 .091 28, .215 33 .206 1. .00 36, .83 1SG1759
ATOM 1759 N ASN 224 77, .998 29, .658 34, .699 1. .00 39, .75 1SG1760
ATOM 1760 CA ASN 224 76 .808 29, .825 35 .468 1. .00 39, .75 1SG1761
ATOM 1761 CB ASN 224 76, .697 28. .844 36, .647 1. .00 39. .75 1SG1762
ATOM 1762 CG ASN 224 76, .471 27. .442 36, .108 1. .00 39. .75 1SG1763
ATOM 1763 ODl ASN 224 77, .289 26. .896 35 .369 1. .00 39 .75 1SG1764
ATOM 1764 ND2 ASN 224 75. .322 26. .833 36, .503 1. .00 39, .75 1SG1765
ATOM 1765 C ASN 224 76, .910 31. .182 36 .082 1. .00 39, .75 1SG1766
ATOM 1766 O ASN 224 78, .002 31, .617 36 .446 1, .00 39 .75 1SG1767
ATOM 1767 N VAL 225 75. .783 31, .909 36 .203 1, .00 41, .63 1SG1768
ATOM 1768 CA VAL 225 75. .889 33, .156 36 .899 1, .00 41, .63 1SG1769
ATOM 1769 CB VAL 225 76. .232 34. .359 36, .061 1, .00 41, .63 1SG1770
ATOM 1770 CGI VAL 225 77. .558 34, .087 35 .331 1, .00 41 .63 1SG1771
ATOM 1771 CG2 VAL 225 75. .052 34, .734 35 .159 1 .00 41 .63 1SG1772
ATOM 1772 C VAL 225 74. .579 33, .410 37, .560 1, .00 41. .63 1SG1773
ATOM 1773 O VAL 225 73. .542 32, .910 37, .126 1, .00 41 .63 1SG1774
ATOM 1774 N THR 226 74. .599 34. .190 38, .656 1, .00 41, .61 1SG1775
ATOM 1775 CA THR 226 73. .365 34, .449 39. .325 1. .00 41 .61 1SG1776
ATOM 1776 CB THR 226 73. .375 34, .086 40. .783 1 .00 41 .61 1SG1777
ATOM 1777 OGl THR 226 72. .050 34. .089 41, .290 1, .00 41, .61 1SG1778
ATOM 1778 CG2 THR 226 74, .239 35. .095 41. .558 1, .00 41 .61 1SG1779
ATOM 1779 C THR 226 73, .091 35. .910 39, .202 1 .00 41 .61 1SG1780
ATOM 1780 O THR 226 73, .979 36. .743 39, .384 1, .00 41 .61 1SG1781
ATOM 1781 N LEU 227 71, .839 36, .259 38. .853 1, .00 39 .82 1SG1782
ATOM 1782 CA LEU 227 71. .508 37. .644 38. .731 1. .00 39, .82 1SG1783
ATOM 1783 CB LEU 227 70. .661 38. .011 37. .492 1, .00 39, .82 1SG1784
ATOM 1784 CG LEU 227 71. .293 37. .642 36, .133 1, .00 39 .82 1SG1785
ATOM 1785 CD2 LEU 227 71. .145 36. .149 35. .808 1. .00 39, .82 1SG1786
ATOM 1786 CDl LEU 227 72, .733 38, .169 36. .022 1. .00 39, .82 1SG1787
ATOM 1787 C LEU 227 70. .692 38. .001 39. .929 1. .00 39. .82 1SG1788
ATOM 1788 O LEU 227 69. .781 37. .269 40. .315 1, .00 39. .82 1SG1789
ATOM 1789 N SER 228 71. .016 39. .151 40. .550 1. .00 35. .62 1SG1790
ATOM 1790 CA SER 228 70. .303 39. .595 41. .709 1. .00 35. .62 1SG1791
ATOM 1791 CB SER 228 71. .206 39. .859 42. .926 1. .00 35. .62 1SG1792
ATOM 1792 OG SER 228 72. .103 40, .924 42. .645 1, .00 35, .62 1SG1793
ATOM 1793 C SER 228 69. .655 40. .891 41. .343 1. .00 35. .62 1SG1794
ATOM 1794 O SER 228 70. .016 41. .527 40. .355 1, .00 35. .62 1SG1795
ATOM 1795 N THR 229 68. .665 41. ,309 42. .150 1. .00 32. .97 1SG1796
ATOM 1796 CA THR 229 67. .916 42. .503 41. .891 1. .00 32. .97 1SG1797
ATOM 1797 CB THR 229 66, .832 42. .736 42. .902 1. .00 32. .97 1SG1798
ATOM 1798 OGl THR 229 66. .002 43. ,813 42. .493 1. .00 32. .97 1SG1799
ATOM 1799 CG2 THR 229 67. .482 43. .048 44. .260 1. .00 32. .97 1SG1800
ATOM 1800 C THR 229 68. .832 43. .688 41. .933 1. .00 32, .97 1SG1801
ATOM 1801 O THR 229 68. ,647 44. .650 41. .190 1. .00 32. .97 1SG1802 ATOM 1802 N GLU 230 69..846 43..645 42.815 1,.00 30,.99 1SG1803
ATOM 1803 CA GLU 230 70, .754 44. .737 43 .039 1, .00 30, .99 1SG1804
ATOM 1804 CB GLU 230 71 .781 44, .422 44 .139 1 .00 30 .99 1SG1805
ATOM 1805 CG GLU 230 71, .149 44, .229 45, .519 1, .00 30, .99 1SG1806
ATOM 1806 CD GLU 230 72, .265 43, .926 46 .509 1, .00 30, .99 1SG1807
ATOM 1807 OEl GLU 230 73 .447 43, .887 46 .075 1 .00 30 .99 1SG1808
ATOM 1808 OE2 GLU 230 71 .949 43 .730 47 .713 1 .00 30 .99 1SG1809
ATOM 1809 C GLU 230 71, .528 45, .062 41, .796 1, .00 30, .99 1SG1810
ATOM 1810 O GLU 230 71, .861 46. .220 41 .553 1, .00 30, .99 1SG1811
ATOM 1811 N GLU 231 71 .841 44, .045 40 .977 1 .00 32 .93 1SG1812
ATOM 1812 CA GLU 231 72 .677 44 .205 39 .820 1 .00 32 .93 1SG1813
ATOM 1813 CB GLU 231 72, .911 42, .881 39, .073 1. .00 32, .93 1SG1814
ATOM 1814 CG GLU 231 73, .724 41, .863 39 .875 1, .00 32, .93 1SG1815
ATOM 1815 CD GLU 231 73, .881 40, .609 39 .026 1 .00 32 .93 1SG1816
ATOM 1816 OEl GLU 231 73 .359 40 .603 37 .880 1 .00 32 .93 1SG1817
ATOM 1817 OE2 GLU 231 74, .525 39, .642 39, .513 1, .00 32, .93 1SG1818
ATOM 1818 C GLU 231 72 .080 45, .168 38 .838 1, .00 32, .93 1SG1819
ATOM 1819 O GLU 231 72 .813 45. .849 38 .120 1 .00 32 .93 1SG1820
ATOM 1820 N ILE 232 70 .741 45 .256 38 .756 1 .00 39 .35 1SG1821
ATOM 1821 CA ILE 232 70, .159 46, .059 37, .718 1. .00 39, .35 1SG1822
ATOM 1822 CB ILE 232 69, .051 45, .332 37 .001 1 .00 39 .35 1SG1823
ATOM 1823 CG2 ILE 232 68 .417 46. .272 35 .962 1 .00 39 .35 1SG1824
ATOM 1824 CGI ILE 232 69 .592 44, .032 36 .383 1 .00 39 .35 1SG1825
ATOM 1825 CDl ILE 232 68, .494 43, .083 35, .903 1, .00 39, .35 1SG1826
ATOM 1826 C ILE 232 69 .587 47, .330 38 .268 1, .00 39 .35 1SG1827
ATOM 1827 O ILE 232 69 .172 47, .409 39 .423 1 .00 39 .35 1SG1828
ATOM 1828 N SER 233 69 .601 48, .378 37 .416 1 .00 49 .05 1SG1829
ATOM 1829 CA SER 233 69, .055 49, .669 37, .720 1, .00 49, .05 1SG1830
ATOM 1830 CB SER 233 69, .537 50. .781 36, .774 1, .00 49, .05 1SG1831
ATOM 1831 OG SER 233 70 .938 50, .967 36 .914 1, .00 49 .05 1SG1832
ATOM 1832 C SER 233 67 .572 49. .547 37 .562 1 .00 49 .05 1SG1833
ATOM 1833 O SER 233 67, .044 48. .445 37. .426 1, .00 49, .05 1SG1834
ATOM 1834 N ASN 234 66, .855 50. .687 37. .602 1, .00 58, .68 1SG1835
ATOM 1835 CA ASN 234 65, .420 50. .670 37, .567 1, .00 58 .68 1SG1836
ATOM 1836 CB ASN 234 64, .781 51. .990 38, .031 1, .00 58 .68 1SG1837
ATOM 1837 CG ASN 234 65 .056 52. .149 39 .520 1, .00 58 .68 1SG1838
ATOM 1838 ODl ASN 234 64, .868 51. .219 40, .302 1, .00 58, .68 1SG1839
ATOM 1839 ND2 ASN 234 65, .521 53, .362 39, .924 1, .00 58, .68 1SG1840
ATOM 1840 C ASN 234 64, .894 50. .384 36, .204 1. .00 58, .68 1SG1841
ATOM 1841 O ASN 234 65, .573 50. .564 35, .197 1, .00 58, .68 1SG1842
ATOM 1842 N HIS 235 63 , .637 49. .890 36, .193 1. .00 64. .14 1SG1843
ATOM 1843 CA HIS 235 62, .863 49. .522 35, .046 1. .00 64. .14 1SG1844
ATOM 1844 NDl HIS 235 62, .266 47. .846 32, .142 1. .00 64. .14 1SG1845
ATOM 1845 CG HIS 235 62, .849 49, .025 32, .553 1. .00 64. .14 1SG1846
ATOM 1846 CB HIS 235 63. .685 49. ,173 33. .791 1. .00 64. .14 1SG1847
ATOM 1847 NE2 HIS 235 61. .710 49. .386 30. .637 1. .00 64. .14 1SG1848
ATOM 1848 CD2 HIS 235 62. .499 49. .955 31. .622 1. .00 64. .14 1SG1849
ATOM 1849 CE1 HIS 235 61. .598 48. .119 30, .992 1. .00 64. .14 1SG1850
ATOM 1850 C HIS 235 62. .193 48. ,274 35. .493 1. .00 64. .14 1SG1851
ATOM 1851 O HIS 235 61. .432 48. ,269 36. .461 1. .00 64. .14 1SG1852
ATOM 1852 N PHE 236 62. .464 47. .163 34. .791 1. .00 64. .67 1SG1853
ATOM 1853 CA PHE 236 61. .917 45. .943 35. .279 1. .00 64. .67 1SG1854
ATOM 1854 CB PHE 236 61. ,922 44. 778 34. ,263 1. ,00 64. ,67 1SG1855
ATOM 1855 CG PHE 236 63. .322 44. .341 34. .027 1. .00 64. .67 1SG1856
ATOM 1856 CDl PHE 236 64. ,180 45. .139 33. .310 1. .00 64. ,67 1SG1857
ATOM 1857 CD2 PHE 236 63. .779 43. ,153 34. .548 1. .00 64. .67 1SG1858
ATOM 1858 CE1 PHE 236 65. .476 44. 746 33. .096 1. .00 64. .67 1SG1859 ATOM 1859 CE2 PHE 236 65..074 42..752 34,.333 1..00 64,.67 1SG1860
ATOM 1860 CZ PHE 236 65. .922 43. .550 33, .604 1. .00 64, .67 1SG1861
ATOM 1861 C PHE 236 62, .759 45. .595 36 .461 1. .00 64 .67 1SG1862
ATOM 1862 O PHE 236 63, .916 46. .005 36 .555 1. .00 64, .67 1SG1863
ATOM 1863 N VAL 237 62. .178 44. .879 37, .437 1. .00 57, .06 1SG1864
ATOM 1864 CA VAL 237 62. .935 44, .534 38 .601 1. .00 57 .06 1SG1865
ATOM 1865 CB VAL 237 62. .470 45, .228 39 .847 1, .00 57, .06 1SG1866
ATOM 1866 CGI VAL 237 62. .670 46, .743 39 .668 1. .00 57, .06 1SG1867
ATOM 1867 CG2 VAL 237 61, .013 44, .819 40 .121 1. .00 57 .06 1SG1868
ATOM 1868 C VAL 237 62, .753 43, .074 38 .821 1. .00 57, .06 1SG1869
ATOM 1869 O VAL 237 61, .760 42. .491 38 .389 1. .00 57, .06 1SG1870
ATOM 1870 N GLN 238 63, .731 42. .433 39 .486 1, .00 50 .65 1SG1871
ATOM 1871 CA GLN 238 63, .572 41. .041 39 .763 1, .00 50, .65 1SG1872
ATOM 1872 CB GLN 238 64, .906 40. .284 39, .880 1. .00 50, .65 1SG1873
ATOM 1873 CG GLN 238 65, .694 40. .231 38 .569 1. .00 50 .65 1SG1874
ATOM 1874 CD GLN 238 64, .931 39, .341 37 .598 1. .00 50 .65 1SG1875
ATOM 1875 OEl GLN 238 63. .870 38, .812 37, .925 1. .00 50 .65 1SG1876
ATOM 1876 NE2 GLN 238 65 .485 39 .169 36 .368 1, .00 50 .65 1SG1877
ATOM 1877 C GLN 238 62, .905 40, .984 41 .094 1. .00 50 .65 1SG1878
ATOM 1878 O GLN 238 63, .535 40, .697 42 .111 1. .00 50 .65 1SG1879
ATOM 1879 N ASN 239 61 .590 41 .271 41 .102 1. .00 44 .89 1SG1880
ATOM 1880 CA ASN 239 60, .822 41, .253 42 .308 1, .00 44 .89 1SG1881
ATOM 1881 CB ASN 239 60, .553 42, .662 42 .871 1. .00 44 .89 1SG1882
ATOM 1882 CG ASN 239 59 .989 42 .544 44 .281 1, .00 44 .89 1SG1883
ATOM 1883 ODl ASN 239 58, .885 42, .049 44 .497 1, .00 44 .89 1SG1884
ATOM 1884 ND2 ASN 239 60, .778 43, .021 45 .281 1. .00 44 .89 1SG1885
ATOM 1885 C ASN 239 59 .511 40 .645 41 .942 1. .00 44 .89 1SG1886
ATOM 1886 O ASN 239 59, .063 40, .756 40 .802 1. .00 44 .89 1SG1887
ATOM 1887 N SER 240 58, .865 39, .969 42, .906 1. .00 40, .86 1SG1888
ATOM 1888 CA SER 240 57. .610 39, .343 42 .631 1. .00 40 .86 1SG1889
ATOM 1889 CB SER 240 57, .063 38, .571 43 .841 1. .00 40 .86 1SG1890
ATOM 1890 OG SER 240 55, .819 37. .974 43, .509 1. .00 40, .86 1SG1891
ATOM 1891 C SER 240 56, .623 40. .415 42 .300 1. .00 40 .86 1SG1892
ATOM 1892 O SER 240 55, .715 40, .210 41 .496 1. .00 40, .86 1SG1893
ATOM 1893 N GLN 241 56, .777 41, .600 42, .918 1. .00 40, .08 1SG1894
ATOM 1894 CA GLN 241 55, .826 42, .651 42 .702 1. .00 40 .08 1SG1895
ATOM 1895 CB GLN 241 56, .133 43, .898 43 .554 1. .00 40 .08 1SG1896
ATOM 1896 CG GLN 241 55, .112 45. .034 43, .422 1. ,00 40, .08 1SG1897
ATOM 1897 CD GLN 241 55, .415 45. .830 42 .160 1. .00 40 .08 1SG1898
ATOM 1898 OEl GLN 241 54, .410 45. .335 42 .668 1. .00 40, .08 1SG1899
ATOM 1899 NE2 GLN 241 56, .741 45, .934 42, .444 1. .00 40, .08 1SG1900
ATOM 1900 C GLN 241 55, .835 43, .058 41 .260 1. .00 40, .08 1SG1901
ATOM 1901 O GLN 241 54 , .777 43. .152 40, .639 1. ,00 40, .08 1SG1902
ATOM 1902 N GLY 242 57. .027 43. .295 40, .678 1. ,00 36. .24 1SG1903
ATOM 1903 CA GLY 242 57. .079 43, .727 39 .309 1. .00 36, .24 1SG1904
ATOM 1904 C GLY 242 56. .533 42. .642 38, .443 1. ,00 36. .24 1SG1905
ATOM 1905 O GLY 242 55. .754 42. .887 37, .523 1. ,00 36. .24 1SG1906
ATOM 1906 N LEU 243 56. .925 41. .395 38, .742 1. ,00 35. .29 1SG1907
ATOM 1907 CA LEU 243 56. .505 40. .259 37, .980 1. ,00 35. .29 1SG1908
ATOM 1908 CB LEU 243 57. .189 38. .952 38, .386 1. ,00 35. .29 1SG1909
ATOM 1909 CG LEU 243 58. .711 38. .956 38, .151 1. ,00 35. .29 1SG1910
ATOM 1910 CD2 LEU 243 59. .052 39. .352 36. .706 1. ,00 35. .29 1SG1911
ATOM 1911 CDl LEU 243 59. .344 37. ,620 38. .570 1. 00 35. .29 1SG1912
ATOM 1912 C LEU 243 55. .029 40. .120 38, .150 1. ,00 35. .29 1SG1913
ATOM 1913 O LEU 243 54. .366 39. .444 37. .369 1. 00 35. .29 1SG1914
ATOM 1914 N GLY 244 54. .479 40. .733 39. ,209 1. 00 36. ,82 1SG1915
ATOM 1915 CA GLY 244 53. .073 40. .640 39. .486 1. ,00 36. .82 1SG1916 ATOM 1916 C GLY 244 52..298 41..176 38.,321 1..00 36..82 1SG1917
ATOM 1917 O GLY 244 51. .179 40. .741 38. .056 1. .00 36. .82 1SG1918
ATOM 1918 N ASN 245 52. .859 42. .162 37. .603 1. .00 43. .41 1SG1919
ATOM 1919 CA ASN 245 52. .147 42, .762 36. .514 1. .00 43. .41 1SG1920
ATOM 1920 CB ASN 245 52, .975 43, .841 35. .794 1. .00 43. .41 1SG1921
ATOM 1921 CG ASN 245 52, .072 44. .573 34. .810 1. .00 43. .41 1SG1922
ATOM 1922 ODl ASN 245 51. .459 43. .967 33. .933 1. .00 43. .41 1SG1923
ATOM 1923 ND2 ASN 245 51. .984 45. .921 34. .961 1. .00 43, .41 1SG1924
ATOM 1924 C ASN 245 51 .789 41, .710 35. .506 1. .00 43 .41 1SG1925
ATOM 1925 O ASN 245 50. .705 41, .755 34. .925 1, .00 43 .41 1SG1926
ATOM 1926 N VAL 246 52, .682 40, .730 35. .260 1. .00 56 .27 1SG1927
ATOM 1927 CA VAL 246 52, .388 39. .782 34. .225 1. .00 56, .27 1SG1928
ATOM 1928 CB VAL 246 53, .472 39, .748 33. .189 1. .00 56, .27 1SG1929
ATOM 1929 CGI VAL 246 53. .444 41, .081 32. .421 1, .00 56, .27 1SG1930
ATOM 1930 CG2 VAL 246 54 .813 39 .514 33, .902 1. .00 56 .27 1SG1931
ATOM 1931 C VAL 246 52 .184 38, .383 34 , .747 1. .00 56 .27 1SG1932
ATOM 1932 O VAL 246 51 .424 37, .629 34. .140 1, .00 56 .27 1SG1933
ATOM 1933 N LEU 247 52 .840 37, .961 35. .853 1, .00 68 .37 1SG1934
ATOM 1934 CA LEU 247 52. .573 36, .608 36. .262 1, .00 68 .37 1SG1935
ATOM 1935 CB LEU 247 53 .721 35, .614 36. .007 1. .00 68 .37 1SG1936
ATOM 1936 CG LEU 247 54 .083 35 .422 34. .523 1 .00 68 .37 1SG1937
ATOM 1937 CD2 LEU 247 54 .701 34 .044 34. .274 1 .00 68 .37 1SG1938
ATOM 1938 CDl LEU 247 54 .933 36, .575 33. .978 1. .00 68 .37 1SG1939
ATOM 1939 C LEU 247 52 .285 36, .519 37. .728 1. .00 68 .37 1SG1940
ATOM 1940 O LEU 247 53. .182 36, .236 38. .522 1. .00 68 .37 1SG1941
ATOM 1941 N SER 248 51 .013 36 .686 38. .143 1 .00 75 .54 1SG1942
ATOM 1942 CA SER 248 50 .786 36 .567 39. .553 1 .00 75 .54 1SG1943
ATOM 1943 CB SER 248 50 .552 37 .925 40. .242 1 .00 75 .54 1SG1944
ATOM 1944 OG SER 248 49 .385 38 .548 39, .726 1. .00 75 .54 1SG1945
ATOM 1945 C SER 248 49 .587 35 .715 39, .833 1. .00 75 .54 1SG1946
ATOM 1946 O SER 248 48, .448 36, .146 39. .649 1. .00 75 .54 1SG1947
ATOM 1947 N ARG 249 49 .804 34 .454 40, .266 1 .00 74 .59 1SG1948
ATOM 1948 CA ARG 249 51 .099 33 .840 40, .300 1 .00 74 .59 1SG1949
ATOM 1949 CB ARG 249 51 .846 33 .877 38, .956 1 .00 74 .59 1SG1950
ATOM 1950 CG ARG 249 51 .145 33 .083 37. .852 1, .00 74 .59 1SG1951
ATOM 1951 CD ARG 249 49 .814 33, .695 37. .410 1. .00 74 .59 1SG1952
ATOM 1952 NE ARG 249 49 .252 32, .823 36. .341 1. .00 74 .59 1SG1953
ATOM 1953 CZ ARG 249 48 .493 31 .740 36. .674 1, .00 74 .59 1SG1954
ATOM 1954 NHl ARG 249 48 .246 31 .456 37, .987 1, .00 74 .59 1SG1955
ATOM 1955 NH2 ARG 249 47 .978 30 .939 35, .696 1, .00 74 .59 1SG1956
ATOM 1956 C ARG 249 52 .009 34, .341 41. .380 1, .00 74 .59 1SG1957
ATOM 1957 O ARG 249 51, .649 34, .402 42. .554 1, .00 74, .59 1SG1958
ATOM 1958 N ILE 250 53 .251 34 .702 40, .981 1 .00 65 .31 1SG1959
ATOM 1959 CA ILE 250 54 .289 34 .967 41, .936 1, .00 65 .31 1SG1960
ATOM 1960 CB ILE 250 55, .644 35 .308 41. .395 1, .00 65, .31 1SG1961
ATOM 1961 CG2 ILE 250 56, .061 34, .162 40. .458 1, .00 65, .31 1SG1962
ATOM 1962 CGI ILE 250 55, .700 36, .684 40. .742 1, .00 65, .31 1SG1963
ATOM 1963 CDl ILE 250 57, .146 37, .163 40. .699 1. .00 65, .31 1SG1964
ATOM 1964 C ILE 250 53 .905 36 .024 42, .914 1. .00 65 .31 1SG1965
ATOM 1965 O ILE 250 54 .287 35 .943 44 , .080 1. .00 65, .31 1SG1966
ATOM 1966 N ALA 251 53, .184 37, .072 42 , .493 1. .00 53. .50 1SG1967
ATOM 1967 CA ALA 251 52, .812 38, .025 43. .494 1. .00 53. .50 1SG1968
ATOM 1968 CB ALA 251 52, .019 39. .213 42. .925 1. .00 53. .50 1SG1969
ATOM 1969 C ALA 251 51 .931 37. .324 44. .484 1, .00 53 .50 1SG1970
ATOM 1970 O ALA 251 52 .083 37 .496 45. .693 1. .00 53. .50 1SG1971
ATOM 1971 N GLU 252 50, .976 36, .510 43. .989 1. .00 47. .76 1SG1972
ATOM 1972 CA GLU 252 50, .041 35, .853 44. .859 1. .00 47. .76 1SG1973 ATOM 1973 CB GLU 252 48..922 35..136 44..085 1.,00 47..76 1SG1974
ATOM 1974 CG GLU 252 47, .986 36, .092 43. .343 1. .00 47. .76 1SG1975
ATOM 1975 CD GLU 252 47, .182 36. .860 44. .382 1. .00 47. .76 1SG1976
ATOM 1976 OEl GLU 252 47. .397 36. .611 45. .598 1. .00 47. .76 1SG1977
ATOM 1977 OE2 GLU 252 46. .343 37. .706 43. .973 1. .00 47. .76 1SG1978
ATOM 1978 C GLU 252 50. .702 34. .825 45. .731 1. .00 47. .76 1SG1979
ATOM 1979 O GLU 252 50. .553 34. .860 46 , .952 1. .00 47. .76 1SG1980
ATOM 1980 N ILE 253 51. .455 33, .876 45. .135 1. .00 47. .89 1SG1981
ATOM 1981 CA ILE 253 52. .039 32, .829 45. .929 1. .00 47. .89 1SG1982
ATOM 1982 CB ILE 253 52. .708 31. .775 45. .096 1. .00 47. .89 1SG1983
ATOM 1983 CG2 ILE 253 53. .434 30, .811 46, .048 1. .00 47. .89 1SG1984
ATOM 1984 CGI ILE 253 51. .682 31, .083 44. .183 1. .00 47. .89 1SG1985
ATOM 1985 CDl ILE 253 50. .565 30. .375 44. .949 1. .00 47. .89 1SG1986
ATOM 1986 C ILE 253 53. .083 33. .417 46. .816 1. .00 47. .89 1SG1987
ATOM 1987 O ILE 253 53. .067 33. .218 48, .030 1. .00 47. .89 1SG1988
ATOM 1988 N TYR 254 54 .015 34 .187 46 .227 1. .00 54. .25 1SG1989
ATOM 1989 CA TYR 254 54. .992 34. .833 47, .045 1. . 00 54. .25 1SG1990
ATOM 1990 CB TYR 254 56, .430 34. .777 46, .507 1. .00 54. .25 1SG1991
ATOM 1991 CG TYR 254 56 .974 33 .467 46 .954 1, .00 54. .25 1SG1992
ATOM 1992 CDl TYR 254 57, .540 33, .382 48, .204 1, .00 54. .25 1SG1993
ATOM 1993 CD2 TYR 254 56, .919 32, .341 46, .167 1. .00 54 , .25 1SG1994
ATOM 1994 CE1 TYR 254 58, .053 32. .199 48, .671 1. .00 54. .25 1SG1995
ATOM 1995 CE2 TYR 254 57 .432 31 .150 46 .630 1 .00 54 .25 1SG1996
ATOM 1996 CZ TYR 254 57 .999 31 .080 47 .881 1. .00 54 .25 1SG1997
ATOM 1997 OH TYR 254 58 .528 29. .866 48 .366 1. .00 54. .25 1SG1998
ATOM 1998 C TYR 254 54. .556 36, .241 47, .155 1, .00 54. .25 1SG1999
ATOM 1999 O TYR 254 55 .021 37 .127 46 .438 1, .00 54 .25 1SG2000
ATOM 2000 N ILE 255 53 .643 36, .436 48 .121 1, .00 61. .84 1SG2001
ATOM 2001 CA ILE 255 52. .969 37, .657 48. .417 1. .00 61. .84 1SG2002
ATOM 2002 CB ILE 255 51. .777 37. .483 49, .313 1. .00 61. .84 1SG2003
ATOM 2003 CG2 ILE 255 52 .277 36 .997 50 .684 1 .00 61 .84 1SG2004
ATOM 2004 CGI ILE 255 50 .952 38 .780 49 .369 1 .00 61 .84 1SG2005
ATOM 2005 CDl ILE 255 49 .578 38 .600 50 .013 1, .00 61 .84 1SG2006
ATOM 2006 C ILE 255 53, .902 38. .582 49 .092 1, .00 61. .84 1SG2007
ATOM 2007 O ILE 255 54, .863 38, .164 49, .735 1 .00 61 .84 1SG2008
ATOM 2008 N LEU 256 53 .646 39, .887 48 .905 1, .00 63 .47 1SG2009
ATOM 2009 CA LEU 256 54, .498 40, .888 49 .452 1, .00 63. .47 1SG2010
ATOM 2010 CB LEU 256 54 .940 40 .638 50 .906 1 .00 63 .47 1SG2011
ATOM 2011 CG LEU 256 55, .861 41, .737 51 .467 1, .00 63 .47 1SG2012
ATOM 2012 CD2 LEU 256 56 .477 41 .318 52 .811 1 .00 63 .47 1SG2013
ATOM 2013 CDl LEU 256 55 .138 43, .091 51 .539 1, .00 63. .47 1SG2014
ATOM 2014 C LEU 256 55, .689 40, .885 48 .572 1, .00 63, .47 1SG2015
ATOM 2015 O LEU 256 56, .094 39, .849 48. .049 1. .00 63, .47 1SG2016
ATOM 2016 N SER 257 56, .270 42, .064 48 .346 1, .00 61, .27 1SG2017
ATOM 2017 CA SER 257 57, .381 42, .070 47. .464 1, .00 61, .27 1SG2018
ATOM 2018 CB SER 257 57 .954 43, .474 47 .204 1, .00 61, .27 1SG2019
ATOM 2019 OG SER 257 58, .480 44, .017 48, .406 1, .00 61, .27 1SG2020
ATOM 2020 C SER 257 58 .461 41 .241 48 .060 1 .00 61 .27 1SG2021
ATOM 2021 O SER 257 58 .877 41, .436 49 .201 1 .00 61, .27 1SG2022
ATOM 2022 N GLN 258 58, .927 40, .265 47, .266 1, .00 53, .25 1SG2023
ATOM 2023 CA GLN 258 60, .056 39. .472 47, .622 1, . 00 53, .25 1SG2024
ATOM 2024 CB GLN 258 59, .792 37. .966 47. .803 1, .00 53, .25 1SG2025
ATOM 2025 CG GLN 258 59 .210 37 .599 49 .170 1 .00 53 .25 1SG2026
ATOM 2026 CD GLN 258 57, .740 37. .971 49 .196 1, .00 53, .25 1SG2027
ATOM 2027 OEl GLN 258 57, .309 38. .787 50, .010 1, .00 53. .25 1SG2028
ATOM 2028 NE2 GLN 258 56, .946 37. .341 48, .291 1. .00 53. .25 1SG2029
ATOM 2029 C GLN 258 60, .970 39, .631 46, .463 1, .00 53. .25 1SG2030 ATOM 2030 O GLN 258 60.535 39.932 45..353 1,.00 53.25 1SG2031
ATOM 2031 N PRO 259 62 .233 39 .487 46 .711 1. .00 44, .45 1SG2032
ATOM 2032 CA PRO 259 63. .185 39 .609 45, .651 1. .00 44, .45 1SG2033
ATOM 2033 CD PRO 259 62. .802 39 .844 47, .998 1. .00 44, .45 1SG2034
ATOM 2034 CB PRO 259 64. .538 39, .875 46, ,316 1. .00 44, .45 1SG2035
ATOM 2035 CG PRO 259 64 .304 39 .588 47 .812 1. .00 44 .45 1SG2036
ATOM 2036 C PRO 259 63 .138 38 .377 44 .821 1. .00 44 .45 1SG2037
ATOM 2037 O PRO 259 62 .685 37 .343 45 .311 1. .00 44 .45 1SG2038
ATOM 2038 N PHE 260 63. .580 38 .464 43 .556 1. .00 38 .29 1SG2039
ATOM 2039 CA PHE 260 63, .532 37 .294 42, .742 1, .00 38, .29 1SG2040
ATOM 2040 CB PHE 260 62, .682 37, .515 41, .480 1. .00 38, .29 1SG2041
ATOM 2041 CG PHE 260 61 .946 36 .249 41 .220 1, .00 38 .29 1SG2042
ATOM 2042 CDl PHE 260 60 .719 36 .074 41 .818 1, .00 38 .29 1SG2043
ATOM 2043 CD2 PHE 260 62 .444 35 .255 40 .416 1, .00 38 .29 1SG2044
ATOM 2044 CE1 PHE 260 59 .986 34 .929 41 .624 1, .00 38 .29 1SG2045
ATOM 2045 CE2 PHE 260 61 .710 34 .108 40 .225 1, .00 38 .29 1SG2046
ATOM 2046 CZ PHE 260 60, .485 33 .937 40, .821 1, .00 38 .29 1SG2047
ATOM 2047 C PHE 260 64, .953 37, .081 42, .319 1, .00 38 .29 1SG2048
ATOM 2048 O PHE 260 65 .670 38 .042 42 .042 1 .00 38 .29 1SG2049
ATOM 2049 N MET 261 65 .415 35 .815 42 .287 1 .00 34 .62 1SG2050
ATOM 2050 CA MET 261 66 .772 35 .557 41 .899 1, .00 34 .62 1SG2051
ATOM 2051 CB MET 261 67 .593 34 .821 42 .972 1, .00 34 .62 1SG2052
ATOM 2052 CG MET 261 67, .840 35 .651 44, .233 1, .00 34 .62 1SG2053
ATOM 2053 SD MET 261 68, .807 34, .798 45, .514 1, .00 34 .62 1SG2054
ATOM 2054 CE MET 261 68 .776 36 .186 46 .685 1 .00 34 .62 1SG2055
ATOM 2055 C MET 261 66 .724 34 .671 40 .697 1 .00 34 .62 1SG2056
ATOM 2056 O MET 261 65 .890 33 .771 40 .622 1, .00 34 .62 1SG2057
ATOM 2057 N VAL 262 67, .616 34 .913 39 .713 1, .00 34 .39 1SG2058
ATOM 2058 CA VAL 262 67, .592 34 .104 38 .529 1, .00 34 .39 1SG2059
ATOM 2059 CB VAL 262 67, .302 34, .886 37, .281 1, .00 34 .39 1SG2060
ATOM 2060 CGI VAL 262 65, .892 35, .489 37, .397 1, .00 34 .39 1SG2061
ATOM 2061 CG2 VAL 262 68 .414 35 .930 37 .089 1 .00 34 .39 1SG2062
ATOM 2062 C VAL 262 68 .934 33 .469 38 .347 1. .00 34 .39 1SG2063
ATOM 2063 O VAL 262 69, .970 34, .096 38, .563 1, .00 34 .39 1SG2064
ATOM 2064 N ARG 263 68, .949 32, .185 37, .935 1, .00 34 .36 1SG2065
ATOM 2065 CA ARG 263 70, .207 31, .527 37, .746 1, .00 34, .36 1SG2066
ATOM 2066 CB ARG 263 70. .349 30, .219 38, .545 1. .00 34, .36 1SG2067
ATOM 2067 CG ARG 263 70 .372 30 .430 40 .060 1 .00 34 .36 1SG2068
ATOM 2068 CD ARG 263 70. .520 29, .132 40 .856 1, .00 34 .36 1SG2069
ATOM 2069 NE ARG 263 69. .316 28, .298 40, .586 1, .00 34 .36 1SG2070
ATOM 2070 CZ ARG 263 69, .288 26, .992 40, .982 1, .00 34, .36 1SG2071
ATOM 2071 NHl ARG 263 70, .363 26, .453 41, .630 1. .00 34, .36 1SG2072
ATOM 2072 NH2 ARG 263 68. .187 26. .225 40, .731 1. .00 34, .36 1SG2073
ATOM 2073 C ARG 263 70. .340 31. .177 36, .299 1. .00 34, .36 1SG2074
ATOM 2074 O ARG 263 69, .428 30, .609 35, .699 1. .00 34, .36 1SG2075
ATOM 2075 N ILE 264 71, .495 31, .519 35, .690 1. .00 33, .73 1SG2076
ATOM 2076 CA ILE 264 71, .663 31, .161 34. .313 1. .00 33. .73 1SG2077
ATOM 2077 CB ILE 264 71. .905 32. .304 33. .371 1. .00 33. .73 1SG2078
ATOM 2078 CG2 ILE 264 70. .704 33. .259 33. .467 1. .00 33. .73 1SG2079
ATOM 2079 CGI ILE 264 73. .251 32. ,970 33. .659 1. .00 33. .73 1SG2080
ATOM 2080 CDl ILE 264 73. .698 33, ,936 32. .563 1. .00 33. .73 1SG2081
ATOM 2081 C ILE 264 72. .833 30, ,236 34. .215 1. .00 33. .73 1SG2082
ATOM 2082 O ILE 264 73. .920 30. ,523 34. .716 1. .00 33. .73 1SG2083
ATOM 2083 N MET 265 72. .614 29. .080 33. .561 1. ,00 32. .00 1SG2084
ATOM 2084 CA MET 265 73. .630 28. .081 33. .397 1. ,00 32. .00 1SG2085
ATOM 2085 CB MET 265 73. .344 26. ,794 34. ,188 1. .00 32. ,00 1SG2086
ATOM 2086 CG MET 265 74. .418 25. .716 34. .025 1. .00 32. .00 1SG2087 ATOM 2087 SD MET 265 73..920 24..058 34..584 1.00 32..00 1SG2088
ATOM 2088 CE MET 265 73, .639 24, .520 36. .317 1. .00 32. .00 1SG2089
ATOM 2089 C MET 265 73. .624 27, .674 31. ,959 1. ,00 32, .00 1SG2090
ATOM 2090 O MET 265 72 , .663 27, .927 31. .233 1. .00 32. .00 1SG2091
ATOM 2091 N ALA 266 74, .719 27, .028 31. .510 1. .00 31, .28 1SG2092
ATOM 2092 CA ALA 266 74 , .776 26, .568 30. .154 1. .00 31. .28 1SG2093
ATOM 2093 CB ALA 266 76, .197 26 .563 29. .563 1. .00 31, .28 1SG2094
ATOM 2094 C ALA 266 74. .287 25, .157 30. .164 1. ,00 31. .28 1SG2095
ATOM 2095 O ALA 266 74, .773 24, .326 30. .929 1. .00 31, .28 1SG2096
ATOM 2096 N THR 267 73 , .263 24, .871 29. .336 1. .00 33. .55 1SG2097
ATOM 2097 CA THR 267 72, .688 23, .558 29. .262 1. .00 33. .55 1SG2098
ATOM 2098 CB THR 267 71, .432 23, .529 28. .442 1. .00 33. .55 1SG2099
ATOM 2099 OGl THR 267 71, .718 23, .882 27. .097 1. .00 33, .55 1SG2100
ATOM 2100 CG2 THR 267 70, .428 24, .524 29. .048 1. .00 33. .55 1SG2101
ATOM 2101 C THR 267 73, .650 22, .601 28. .627 1. .00 33. .55 1SG2102
ATOM 2102 O THR 267 73. .872 21, .503 29. .136 1. .00 33. .55 1SG2103
ATOM 2103 N GLU 268 74, .255 23, .002 27. .490 1, .00 37. .09 1SG2104
ATOM 2104 CA GLU 268 75, .127 22 , .121 26. .762 1. .00 37. .09 1SG2105
ATOM 2105 CB GLU 268 74, .469 21, .590 25. .473 1, .00 37. .09 1SG2106
ATOM 2106 CG GLU 268 75, .315 20 .594 24, ,678 1. .00 37. .09 1SG2107
ATOM 2107 CD GLU 268 74, .513 20, .175 23. .454 1. .00 37, .09 1SG2108
ATOM 2108 OEl GLU 268 73 .361 20 .662 23. .306 1. .00 37, .09 1SG2109
ATOM 2109 OE2 GLU 268 75, .043 19, .360 22, .651 1. .00 37, .09 1SG2110
ATOM 2110 C GLU 268 76 .338 22 .912 26, .373 1. .00 37, .09 1SG2111
ATOM 2111 O GLU 268 76, .349 24, .134 26. .507 1. .00 37, .09 1SG2112
ATOM 2112 N PRO 269 77 .379 22 .253 25. .925 1, .00 40, .10 1SG2113
ATOM 2113 CA PRO 269 78, .547 22, .987 25. .523 1. .00 40, .10 1SG2114
ATOM 2114 CD PRO 269 77, .730 20 .950 26. .468 1. .00 40, .10 1SG2115
ATOM 2115 CB PRO 269 79, .656 21, .953 25. .360 1. .00 40, .10 1SG2116
ATOM 2116 CG PRO 269 79, .263 20 .858 26. .371 1. .00 40, .10 1SG2117
ATOM 2117 C PRO 269 78, .265 23 .812 24. .312 1. .00 40, .10 1SG2118
ATOM 2118 O PRO 269 77, .676 23 .303 23 .360 1. .00 40, .10 1SG2119
ATOM 2119 N PRO 270 78, .695 25, .042 24. .321 1. .00 42 , .00 1SG2120
ATOM 2120 CA PRO 270 78, .438 25 .883 23 .190 1, .00 42, .00 1SG2121
ATOM 2121 CD PRO 270 78, .696 25, .803 25. .562 1. .00 42. .00 1SG2122
ATOM 2122 CB PRO 270 78, .742 27, .306 23. .648 1, .00 42, .00 1SG2123
ATOM 2123 CG PRO 270 78 .424 27 .262 25 .155 1, .00 42, .00 1SG2124
ATOM 2124 C PRO 270 79, .193 25, .427 21, .984 1. .00 42, .00 1SG2125
ATOM 2125 O PRO 270 80 .306 24 .919 22 .113 1. .00 42, .00 1SG2126
ATOM 2126 N ILE 271 78, .593 25, .610 20, .797 1. .00 40, .56 1SG2127
ATOM 2127 CA ILE 271 79 .173 25 .163 19 .569 1. .00 40, .56 1SG2128
ATOM 2128 CB ILE 271 78, .188 24, .413 18, .714 1. .00 40. .56 1SG2129
ATOM 2129 CG2 ILE 271 77, .021 25 .360 18, .389 1. .00 40. .56 1SG2130
ATOM 2130 CGI ILE 271 78, .870 23. .831 17. .469 1. .00 40. .56 1SG2131
ATOM 2131 CDl ILE 271 77, .995 22. .857 16. .680 1. .00 40. .56 1SG2132
ATOM 2132 C ILE 271 79. .584 26. .367 18. .791 1. .00 40. .56 1SG2133
ATOM 2133 O ILE 271 78, .873 27. .368 18, .764 1. .00 40. .56 1SG2134
ATOM 2134 N ILE 272 80, .777 26. .313 18. .168 1. .00 39. .47 1SG2135
ATOM 2135 CA ILE 272 81, .213 27. .401 17. .345 1. .00 39. .47 1SG2136
ATOM 2136 CB ILE 272 82. .446 28. .085 17. .854 1. ,00 39. .47 1SG2137
ATOM 2137 CG2 ILE 272 82, .894 29, .105 16. .793 1. .00 39. .47 1SG2138
ATOM 2138 CGI ILE 272 82, .172 28, .709 19. .232 1. .00 39. .47 1SG2139
ATOM 2139 CDl ILE 272 83, .435 29. .169 19, .957 1. ,00 39. .47 1SG2140
ATOM 2140 C ILE 272 81, .533 26. .825 16, .004 1. .00 39. .47 1SG2141
ATOM 2141 O ILE 272 82. .279 25. .853 15, .897 1. ,00 39. ,47 1SG2142
ATOM 2142 N ASN 273 80. .963 27, .408 14, .932 1. .00 43. .25 1SG2143
ATOM 2143 CA ASN 273 81. .241 26. .874 13. .632 1. .00 43. .25 1SG2144 ATOM 2144 CB ASN 273 79..988 26..459 12..837 1..00 43..25 1SG2145
ATOM 2145 CG ASN 273 79. .131 27. .690 12. .631 1. .00 43. .25 1SG2146
ATOM 2146 ODl ASN 273 79. .228 28. .642 13. .401 1. .00 43. .25 1SG2147
ATOM 2147 ND2 ASN 273 78. .266 27, .671 11. .582 1. .00 43. .25 1SG2148
ATOM 2148 C ASN 273 81. .998 27, .899 12, .851 1, .00 43. .25 1SG2149
ATOM 2149 O ASN 273 81. .665 29. .084 12, .852 1, .00 43. .25 1SG2150
ATOM 2150 N LEU 274 83. .074 27. .458 12, .171 1. .00 48, .91 1SG2151
ATOM 2151 CA LEU 274 83. .858 28. .381 11, .403 1. .00 48. .91 1SG2152
ATOM 2152 CB LEU 274 85. .369 28, .282 11, .670 1, .00 48. .91 1SG2153
ATOM 2153 CG LEU 274 85, .752 28, .704 13 , .101 1, .00 48. .91 1SG2154
ATOM 2154 CD2 LEU 274 87, .274 28, .840 13 , .259 1, .00 48. .91 1SG2155
ATOM 2155 CDl LEU 274 85, .125 27, .769 14, .147 1. .00 48. .91 1SG2156
ATOM 2156 C LEU 274 83, .613 28, .113 9, .956 1. .00 48. .91 1SG2157
ATOM 2157 O LEU 274 83, .665 26 .972 9, .499 1. .00 48. .91 1SG2158
ATOM 2158 N GLN 275 83 .322 29 .186 9 .197 1. .00 56. .84 1SG2159
ATOM 2159 CA GLN 275 83, .002 29, .046 7, .809 1. .00 56. .84 1SG2160
ATOM 2160 CB GLN 275 81, .484 28, .983 7, .634 1. .00 56. .84 1SG2161
ATOM 2161 CG GLN 275 80. .914 27, .793 8, .407 1, .00 56. .84 1SG2162
ATOM 2162 CD GLN 275 79. .525 28 .161 8, .899 1. .00 56. .84 1SG2163
ATOM 2163 OEl GLN 275 78. .607 27 .344 8, .895 1, .00 56. .84 1SG2164
ATOM 2164 NE2 GLN 275 79 .377 29 .425 9 .378 1 .00 56, .84 1SG2165
ATOM 2165 C GLN 275 83 .510 30 .275 7 .138 1 .00 56 .84 1SG2166
ATOM 2166 O GLN 275 83 .751 31 .289 7 .791 1 .00 56 .84 1SG2167
ATOM 2167 N PRO 276 83, .707 30, .221 5, .852 1, .00 63, .52 1SG2168
ATOM 2168 CA PRO 276 84, .150 31, .368 5, .127 1, .00 63, .52 1SG2169
ATOM 2169 CD PRO 276 83, .686 29 .004 5, .063 1, .00 63, .52 1SG2170
ATOM 2170 CB PRO 276 84, .269 30 .917 3, .673 1, .00 63. .52 1SG2171
ATOM 2171 CG PRO 276 84 .413 29 .383 3 .762 1, .00 63. .52 1SG2172
ATOM 2172 C PRO 276 83 .013 32 .292 5 .341 1 .00 63 .52 1SG2173
ATOM 2173 O PRO 276 81 .886 31 .855 5 .167 1 .00 63 .52 1SG2174
ATOM 2174 N GLY 277 83, .238 33, .557 5. .697 1, .00 64, .19 1SG2175
ATOM 2175 CA GLY 277 82, .107 34, .406 5, .896 1, .00 64, .19 1SG2176
ATOM 2176 C GLY 277 82, .082 34, .835 7, .324 1, .00 64, .19 1SG2177
ATOM 2177 O GLY 277 82, .085 36, .036 7, .573 1, .00 64, .19 1SG2178
ATOM 2178 N ASN 278 82, .077 33 .885 8, .292 1 .00 61, .48 1SG2179
ATOM 2179 CA ASN 278 82 .068 34 .263 9, .685 1 .00 61, .48 1SG2180
ATOM 2180 CB ASN 278 80 .834 35 .064 10 .167 1 .00 61, .48 1SG2181
ATOM 2181 CG ASN 278 81 .022 36 .569 10 .015 1 .00 61 .48 1SG2182
ATOM 2182 ODl ASN 278 82. .050 37, .125 10, .398 1, .00 61, .48 1SG2183
ATOM 2183 ND2 ASN 278 80. .001 37, .249 9, .429 1, .00 61, .48 1SG2184
ATOM 2184 C ASN 278 82. .048 33, .061 10, .574 1, .00 61, .48 1SG2185
ATOM 2185 O ASN 278 81. .918 31, .920 10, .134 1, .00 61, .48 1SG2186
ATOM 2186 N PHE 279 82. .155 33, .336 11, .891 1, .00 55. .16 1SG2187
ATOM 2187 CA PHE 279 82. .098 32 .341 12, .922 1, .00 55. .16 1SG2188
ATOM 2188 CB PHE 279 83. .025 32 .621 14, .115 1, .00 55. .16 1SG2189
ATOM 2189 CG PHE 279 84. .395 32, .919 13. .635 1, .00 55. .16 1SG2190
ATOM 2190 CDl PHE 279 85. .305 31, .918 13. .395 1. .00 55. .16 1SG2191
ATOM 2191 CD2 PHE 279 84. .757 34, .231 13. .439 1, .00 55. .16 1SG2192
ATOM 2192 CE1 PHE 279 86, .567 32, .234 12. .957 1, .00 55. .16 1SG2193
ATOM 2193 CE2 PHE 279 86, .015 34, .555 13, .003 1, .00 55. .16 1SG2194
ATOM 2194 CZ PHE 279 86, .915 33, .550 12 , .764 1, .00 55. .16 1SG2195
ATOM 2195 C PHE 279 80, .746 32, .510 13, .545 1, .00 55, .16 1SG2196
ATOM 2196 O PHE 279 80, .326 33, .634 13 , .821 1, .00 55, .16 1SG2197
ATOM 2197 N THR 280 80. .033 31. .398 13. .801 1. .00 49. .12 1SG2198
ATOM 2198 CA THR 280 78. .743 31. .505 14. .417 1. .00 49. .12 1SG2199
ATOM 2199 CB THR 280 77. .652 30. .866 13. .610 1. .00 49. .12 1SG2200
ATOM 2200 OGl THR 280 77. .604 31. .419 12. .304 1. .00 49. .12 1SG2201 ATOM 2201 CG2 THR 280 76..319 31..106 14..322 1..00 49..12 1SG2202
ATOM 2202 C THR 280 78. .828 30. ,759 15. .713 1. .00 49. .12 1SG2203
ATOM 2203 0 THR 280 79. .509 29. .738 15. .801 1. .00 49. ,12 1SG2204
ATOM 2204 N LEU 281 78. .151 31. .269 16. ,764 1. .00 45. .24 1SG2205
ATOM 2205 CA LEU 281 78. .188 30. .634 18. .052 1. .00 45. .24 1SG2206
ATOM 2206 CB LEU 281 78. .732 31. .575 19. .154 1. .00 45. .24 1SG2207
ATOM 2207 CG LEU 281 78. .976 30. .959 20. .552 1. .00 45. .24 1SG2208
ATOM 2208 CD2 LEU 281 77. .711 30. .350 21. .179 1. .00 45. .24 1SG2209
ATOM 2209 CDl LEU 281 79. .603 32. .002 21. .490 1. .00 45. .24 1SG2210
ATOM 2210 C LEU 281 76. .781 30. .243 18. .393 1. .00 45. .24 1SG2211
ATOM 2211 0 LEU 281 75. .844 31. .001 18, .149 1 .00 45, .24 1SG2212
ATOM 2212 N ASP 282 76 .592 29, .028 18, .951 1, .00 43, .89 1SG2213
ATOM 2213 CA ASP 282 75. .266 28, .614 19, .319 1 .00 43, .89 1SG2214
ATOM 2214 CB ASP 282 74 .793 27, .349 18, .585 1, .00 43. .89 1SG2215
ATOM 2215 CG ASP 282 74, .546 27, .729 17, .133 1 .00 43, .89 1SG2216
ATOM 2216 ODl ASP 282 74 .574 28 .953 16, .832 1, .00 43, .89 1SG2217
ATOM 2217 OD2 ASP 282 74 .321 26, .805 16, .307 1 .00 43 .89 1SG2218
ATOM 2218 C ASP 282 75 .248 28 .312 20, .787 1, .00 43, .89 1SG2219
ATOM 2219 0 ASP 282 75 .643 27 .229 21, .212 1 .00 43 .89 1SG2220
ATOM 2220 N ILE 283 74 .763 29 .261 21, .612 1 .00 45, .84 1SG2221
ATOM 2221 CA ILE 283 74 .768 29, .018 23, .026 1 .00 45 .84 1SG2222
ATOM 2222 CB ILE 283 75, .426 30 .117 23, .813 1 .00 45 .84 1SG2223
ATOM 2223 CG2 ILE 283 74 .619 31, .413 23, .622 1 .00 45 .84 1SG2224
ATOM 2224 CGI ILE 283 75. .599 29 .691 25, .280 1, .00 45, .84 1SG2225
ATOM 2225 CDl ILE 283 76 .512 30, .617 26, .080 1 .00 45 .84 1SG2226
ATOM 2226 C ILE 283 73 .372 28 .859 23 .544 1, .00 45, .84 1SG2227
ATOM 2227 0 ILE 283 72 .499 29 .699 23, .325 1, .00 45 .84 1SG2228
ATOM 2228 N PRO 284 73. .151 27 .707 24, .134 1, .00 47, .44 1SG2229
ATOM 2229 CA PRO 284 71 .925 27 .447 24, .842 1, .00 47 .44 1SG2230
ATOM 2230 CD PRO 284 73, .690 26 .499 23 .531 1 .00 47, .44 1SG2231
ATOM 2231 CB PRO 284 71 .615 25 .964 24, .637 1, .00 47 .44 1SG2232
ATOM 2232 CG PRO 284 72, .963 25, .346 24 .235 1 .00 47, .44 1SG2233
ATOM 2233 C PRO 284 72 .140 27 .797 26, .281 1, .00 47, .44 1SG2234
ATOM 2234 0 PRO 284 73, .265 27, .695 26, .767 1 .00 47, .44 1SG2235
ATOM 2235 N ALA 285 71 .076 28 .165 27, .006 1, .00 47. ,96 1SG2236
ATOM 2236 CA ALA 285 71. .257 28, .478 28 .389 1 .00 47. .96 1SG2237
ATOM 2237 CB ALA 285 71 .202 29 .984 28, .694 1, .00 47, .96 1SG2238
ATOM 2238 C ALA 285 70, .102 27, .851 29 .058 1, .00 47, .96 1SG2239
ATOM 2239 0 ALA 285 69 .256 27 .287 28, .373 1. .00 47, .96 1SG2240
ATOM 2240 N SER 286 70, .056 27 .912 30, .405 1, .00 47, .28 1SG2241
ATOM 2241 CA SER 286 68, .917 27 .490 31, .172 1. .00 47. .28 1SG2242
ATOM 2242 CB SER 286 69, .145 26, .187 31, .958 1, .00 47. .28 1SG2243
ATOM 2243 OG SER 286 67, .974 25 .845 32. .686 1, .00 47. ,28 1SG2244
ATOM 2244 C SER 286 68, .738 28, .588 32. .173 1, .00 47. .28 1SG2245
ATOM 2245 0 SER 286 69. .659 28 .898 32. .926 1. .00 47. .28 1SG2246
ATOM 2246 N ILE 287 67. .554 29, .232 32. .194 1, .00 45, .36 1SG2247
ATOM 2247 CA ILE 287 67, .369 30 .310 33. .119 1, .00 45, .36 1SG2248
ATOM 2248 CB ILE 287 66, .996 31, .621 32. .478 1, .00 45, .36 1SG2249
ATOM 2249 CG2 ILE 287 68, .155 32, .034 31. .556 1, .00 45. .36 1SG2250
ATOM 2250 CGI ILE 287 65, .637 31, .541 31. .762 1. .00 45, .36 1SG2251
ATOM 2251 CDl ILE 287 65, .082 32, .904 31. .352 1, .00 45, .36 1SG2252
ATOM 2252 C ILE 287 66, .273 29, .912 34. .051 1. .00 45. .36 1SG2253
ATOM 2253 0 ILE 287 65, .162 29, .595 33. .629 1. .00 45, .36 1SG2254
ATOM 2254 N MET 288 66, .573 29, .905 35. .362 1. .00 42, .59 1SG2255
ATOM 2255 CA MET 288 65, .573 29, .525 36. .315 1, .00 42, .59 1SG2256
ATOM 2256 CB MET 288 65. .985 28, .333 37. .196 1. .00 42. .59 1SG2257
ATOM 2257 CG MET 288 66 .165 27 .030 36. .415 1. .00 42, .59 1SG2258 ATOM 2258 SD MET 288 67..628 26..997 35,.336 1..00 42..59 1SG2259
ATOM 2259 CE MET 288 68. .828 26. .946 36, .697 1. .00 42. .59 1SG2260
ATOM 2260 C MET 288 65. .354 30. .686 37, .225 1. .00 42. .59 1SG2261
ATOM 2261 O MET 288 66. .296 31, .351 37, .654 1. .00 42. .59 1SG2262
ATOM 2262 N MET 289 64, .079 30, .965 37 .544 1. .00 40. .90 1SG2263
ATOM 2263 CA MET 289 63. ,792 32, .075 38, .397 1. .00 40. .90 1SG2264
ATOM 2264 CB MET 289 62, .844 33, .084 37, .721 1. .00 40. .90 1SG2265
ATOM 2265 CG MET 289 61, .725 32, .444 36 .898 1. .00 40. .90 1SG2266
ATOM 2266 SD MET 289 60. .603 33. .631 36, .099 1. .00 40. .90 1SG2267
ATOM 2267 CE MET 289 59. .789 34. .159 37, .634 1. .00 40. .90 1SG2268
ATOM 2268 C MET 289 63. .266 31. .552 39 .695 1, .00 40. .90 1SG2269
ATOM 2269 O MET 289 62. ,439 30. .642 39, .733 1. .00 40. .90 1SG2270
ATOM 2270 N LEU 290 63. .795 32. .098 40, .809 1. .00 39. .97 1SG2271
ATOM 2271 CA LEU 290 63. .410 31. .646 42 .114 1. .00 39. .97 1SG2272
ATOM 2272 CB LEU 290 64. .560 31. .000 42, .905 1. .00 39. .97 1SG2273
ATOM 2273 CG LEU 290 65. .098 29. .707 42 .267 1. .00 39. .97 1SG2274
ATOM 2274 CD2 LEU 290 66, .052 28 .969 43 .220 1, .00 39, .97 1SG2275
ATOM 2275 CDl LEU 290 65. .725 29. .981 40, .890 1. .00 39. .97 1SG2276
ATOM 2276 C LEU 290 62. .944 32. .822 42 .905 1, .00 39, .97 1SG2277
ATOM 2277 O LEU 290 63. .344 33, .958 42 .657 1. .00 39, .97 1SG2278
ATOM 2278 N THR 291 62. .064 32. .566 43 .890 1. .00 38. .80 1SG2279
ATOM 2279 CA THR 291 61, .600 33. .619 44 .738 1, .00 38, .80 1SG2280
ATOM 2280 CB THR 291 60, .149 33 .508 45 .100 1, .00 38, .80 1SG2281
ATOM 2281 OGl THR 291 59, .345 33. .507 43, .931 1. .00 38. .80 1SG2282
ATOM 2282 CG2 THR 291 59, .775 34. .696 46 .001 1, .00 38, .80 1SG2283
ATOM 2283 C THR 291 62, .370 33 .457 45 .999 1, .00 38, .80 1SG2284
ATOM 2284 O THR 291 62, .622 32. .335 46, .430 1. .00 38. .80 1SG2285
ATOM 2285 N GLN 292 62, .796 34. .574 46 .613 1, .00 41, .81 1SG2286
ATOM 2286 CA GLN 292 63, .558 34. .436 47 .818 1. .00 41, .81 1SG2287
ATOM 2287 CB GLN 292 64. .727 35, .430 47, .926 1. .00 41, .81 1SG2288
ATOM 2288 CG GLN 292 65, .537 35, .276 49 .215 1. .00 41, .81 1SG2289
ATOM 2289 CD GLN 292 66, .653 36 .310 49 .196 1. .00 41, .81 1SG2290
ATOM 2290 OEl GLN 292 66. .746 37, .125 48, .279 1. .00 41, .81 1SG2291
ATOM 2291 NE2 GLN 292 67. .524 36, .282 50, .240 1, .00 41, .81 1SG2292
ATOM 2292 C GLN 292 62. .649 34, .703 48 .975 1. .00 41, .81 1SG2293
ATOM 2293 O GLN 292 62. .126 35, .804 49, .135 1. .00 41, .81 1SG2294
ATOM 2294 N PRO 293 62. .442 33, .697 49, .780 1, .00 45, .71 1SG2295
ATOM 2295 CA PRO 293 61. .649 33, .897 50 .958 1. .00 45, .71 1SG2296
ATOM 2296 CD PRO 293 62. .182 32, .384 49, .210 1. .00 45. .71 1SG2297
ATOM 2297 CB PRO 293 61. .222 32, .510 51, .429 1. .00 45. .71 1SG2298
ATOM 2298 CG PRO 293 61. .151 31. .706 50 .124 1. .00 45. .71 1SG2299
ATOM 2299 C PRO 293 62. .397 34. .681 51, .984 1. .00 45. .71 1SG2300
ATOM 2300 O PRO 293 63. .616 34. .809 51, .880 1. .00 45. .71 1SG2301
ATOM 2301 N LYS 294 61, .671 35, .201 52 .990 1. .00 48. .76 1SG2302
ATOM 2302 CA LYS 294 62. .238 36. .016 54, .024 1. .00 48. .76 1SG2303
ATOM 2303 CB LYS 294 61. .213 36. .408 55, .102 1. .00 48. .76 1SG2304
ATOM 2304 CG LYS 294 60. .097 37. .320 54, .587 1. .00 48. .76 1SG2305
ATOM 2305 CD LYS 294 58, .918 37. .445 55, .554 1. .00 48. .76 1SG2306
ATOM 2306 CE LYS 294 57. .799 38, .355 55, .044 1. .00 48. .76 1SG2307
ATOM 2307 NZ LYS 294 56, .705 38, .418 56, .038 1. .00 48. .76 1SG2308
ATOM 2308 C LYS 294 63. .290 35. .197 54 , .684 1. .00 48. ,76 1SG2309
ATOM 2309 O LYS 294 64. .287 35. .720 55, .180 1. .00 48. ,76 1SG2310
ATOM 2310 N ASN 295 63. .069 33. .874 54, .711 1. .00 53. .04 1SG2311
ATOM 2311 CA ASN 295 64. .007 32. .981 55. .309 1. .00 53. ,04 1SG2312
ATOM 2312 CB ASN 295 63. ,548 31. .528 55. .104 1. .00 53. ,04 1SG2313
ATOM 2313 CG ASN 295 64. ,723 30. .599 55. .313 1. .00 53. ,04 1SG2314
ATOM 2314 ODl ASN 295 65. ,534 30. ,453 54. .400 1. .00 53. ,04 1SG2315 ATOM 2315 ND2 ASN 295 64..820 29..956 56..507 1..00 53..04 1SG2316
ATOM 2316 C ASN 295 65. .341 33. .173 54. .654 1. .00 53. .04 1SG2317
ATOM 2317 O ASN 295 66. .309 33. .474 55. .347 1. .00 53. ,04 1SG2318
ATOM 2318 N SER 296 65. .412 33. .023 53. ,311 1. .00 52. ,12 1SG2319
ATOM 2319 CA SER 296 66. .600 33. .183 52. .502 1, .00 52. .12 1SG2320
ATOM 2320 CB SER 296 67 .956 33. .072 53. .229 1. .00 52. .12 1SG2321
ATOM 2321 OG SER 296 68. .139 31. .759 53. .738 1. .00 52. ,12 1SG2322
ATOM 2322 C SER 296 66. .583 32. .046 51. ,544 1. .00 52. ,12 1SG2323
ATOM 2323 O SER 296 67. .356 31. .999 50. ,589 1. .00 52, .12 1SG2324
ATOM 2324 N THR 297 65. .674 31. .090 51. .796 1, .00 50, .20 1SG2325
ATOM 2325 CA THR 297 65. .596 29. .926 50. .974 1, .00 50, .20 1SG2326
ATOM 2326 CB THR 297 64. .614 28. ,910 51. .478 1. .00 50. .20 1SG2327
ATOM 2327 OGl THR 297 64. .713 27. ,713 50. .722 1. .00 50. .20 1SG2328
ATOM 2328 CG2 THR 297 63. .196 29. .497 51. .367 1, .00 50. .20 1SG2329
ATOM 2329 C THR 297 65, .154 30. .374 49. .627 1. .00 50. .20 1SG2330
ATOM 2330 O THR 297 64, .855 31. .548 49. .426 1. .00 50. .20 1SG2331
ATOM 2331 N VAL 298 65. .153 29. .454 48. ,645 1. .00 49. .04 1SG2332
ATOM 2332 CA VAL 298 64. .735 29. .850 47. .335 1. .00 49, .04 1SG2333
ATOM 2333 CB VAL 298 65. .828 29. .763 46. .311 1. .00 49, .04 1SG2334
ATOM 2334 CGI VAL 298 66 .943 30. .748 46, .701 1. .00 49, .04 1SG2335
ATOM 2335 CG2 VAL 298 66 .293 28. .300 46, .214 1. .00 49, .04 1SG2336
ATOM 2336 C VAL 298 63. .646 28. .927 46. .892 1. .00 49, .04 1SG2337
ATOM 2337 O VAL 298 63, .736 27. .714 47, .076 1. .00 49, .04 1SG2338
ATOM 2338 N GLU 299 62, .570 29. .486 46, .300 1, .00 47, .42 1SG2339
ATOM 2339 CA GLU 299 61 .541 28. .630 45, .782 1. .00 47, .42 1SG2340
ATOM 2340 CB GLU 299 60 .115 28. .912 46, .285 1 .00 47 .42 1SG2341
ATOM 2341 CG GLU 299 59, .102 27. .940 45, .667 1, .00 47, .42 1SG2342
ATOM 2342 CD GLU 299 57, .769 28. .053 46, .391 1, .00 47, .42 1SG2343
ATOM 2343 OEl GLU 299 57, .684 27. .570 47, .552 1. .00 47, .42 1SG2344
ATOM 2344 OE2 GLU 299 56, .813 28. .611 45, .789 1, .00 47 .42 1SG2345
ATOM 2345 C GLU 299 61 .530 28, .800 44 .296 1 .00 47 .42 1SG2346
ATOM 2346 O GLU 299 61 .438 29, .917 43 , .791 1. .00 47, .42 1SG2347
ATOM 2347 N THR 300 61, .622 27. .675 43 , .557 1, .00 47, .70 1SG2348
ATOM 2348 CA THR 300 61. .720 27. .722 42, .124 1. .00 47, .70 1SG2349
ATOM 2349 CB THR 300 62. .168 26. .424 41 .520 1 .00 47 .70 1SG2350
ATOM 2350 OGl THR 300 61 .217 25, .405 41 .791 1 .00 47 .70 1SG2351
ATOM 2351 CG2 THR 300 63. .533 26. .048 42, .120 1. .00 47. .70 1SG2352
ATOM 2352 C THR 300 60. .400 28. .051 41, .512 1. .00 47. .70 1SG2353
ATOM 2353 O THR 300 59. .449 27. .283 41, .644 1 .00 47. .70 1SG2354
ATOM 2354 N ILE 301 60 .292 29. .237 40 .869 1 .00 49, .16 1SG2355
ATOM 2355 CA ILE 301 59 .075 29. .574 40 .192 1 .00 49, .16 1SG2356
ATOM 2356 CB ILE 301 58. .868 31. .052 40. .010 1. .00 49. .16 1SG2357
ATOM 2357 CG2 ILE 301 59. .952 31. .591 39 .078 1. .00 49. .16 1SG2358
ATOM 2358 CGI ILE 301 57. .435 31, .330 39, .527 1, .00 49, .16 1SG2359
ATOM 2359 CDl ILE 301 56, .366 30, .990 40, .565 1, .00 49, .16 1SG2360
ATOM 2360 C ILE 301 58, .936 28, .878 38 .859 1, .00 49, .16 1SG2361
ATOM 2361 O ILE 301 57. .939 28. .194 38. .627 1. .00 49, .16 1SG2362
ATOM 2362 N VAL 302 59. .942 29, .000 37 .953 1, .00 52, .92 1SG2363
ATOM 2363 CA VAL 302 59. .820 28, .424 36. .629 1, .00 52. .92 1SG2364
ATOM 2364 CB VAL 302 59. .031 29, .304 35. .685 1, .00 52. .92 1SG2365
ATOM 2365 CGI VAL 302 58. .945 28, .642 34. .300 1, .00 52 .92 1SG2366
ATOM 2366 CG2 VAL 302 57. .657 29, .605 36. .300 1, .00 52. .92 1SG2367
ATOM 2367 C VAL 302 61. .190 28. .271 36. .018 1, .00 52. .92 1SG2368
ATOM 2368 O VAL 302 62. .136 28. .965 36. .391 1, .00 52. .92 1SG2369
ATOM 2369 N SER 303 61, .329 27. .345 35. .041 1. .00 58, .39 1SG2370
ATOM 2370 CA SER 303 62. .578 27, .171 34 .353 1 .00 58, .39 1SG2371
ATOM 2371 CB SER 303 63. .121 25. .733 34. .416 1, .00 58. .39 1SG2372 ATOM 2372 OG SER 303 64,.353 25..646 33..715 1..00 58..39 1SG2373
ATOM 2373 C SER 303 62, .332 27. .491 32. .916 1. .00 58. .39 1SG2374
ATOM 2374 O SER 303 61, .414 26. .961 32. .293 1, .00 58. .39 1SG2375
ATOM 2375 N MET 304 63, .158 28. .378 32, .338 1, .00 64, .45 1SG2376
ATOM 2376 CA MET 304 62, .942 28. .740 30. .973 1, .00 64 , .45 1SG2377
ATOM 2377 CB MET 304 62, .757 30. .257 30. .768 1, .00 64, .45 1SG2378
ATOM 2378 CG MET 304 61, .520 30, .869 31. .430 1. .00 64, .45 1SG2379
ATOM 2379 SD MET 304 59, .963 30, .588 30. .540 1. .00 64, .45 1SG2380
ATOM 2380 CE MET 304 60, .002 28 .799 30, .823 1. .00 64, .45 1SG2381
ATOM 2381 C MET 304 64. .195 28, .443 30. .316 1. .00 64. .45 1SG2382
ATOM 2382 O MET 304 65 .197 28 .405 31. .024 1, .00 64, .45 1SG2383
ATOM 2383 N ASP 305 64, .150 28, .155 28. .994 1. .00 66. .82 1SG2384
ATOM 2384 CA ASP 305 65. .389 28 .248 28. .313 1. .00 66. .82 1SG2385
ATOM 2385 CB ASP 305 66. .746 27, .940 28. .898 1. .00 66. .82 1SG2386
ATOM 2386 CG ASP 305 67. .120 29 .368 29. .414 1. .00 66. .82 1SG2387
ATOM 2387 ODl ASP 305 66 .144 30 .162 29. .447 1, .00 66 .82 1SG2388
ATOM 2388 OD2 ASP 305 68. .282 29, .727 29. .727 1, .00 66. .82 1SG2389
ATOM 2389 C ASP 305 65 .395 28 .640 26. .908 1 .00 66 .82 1SG2390
ATOM 2390 O ASP 305 64. .502 28, .435 26. .088 1, .00 66. .82 1SG2391
ATOM 2391 N PHE 306 66 .495 29 .364 26. .719 1, .00 62. .29 1SG2392
ATOM 2392 CA PHE 306 66. .831 30, .169 25. .628 1, .00 62. .29 1SG2393
ATOM 2393 CB PHE 306 67 .082 31 .608 26, .104 1 .00 62, .29 1SG2394
ATOM 2394 CG PHE 306 67 .998 32 .284 25. .154 1 .00 62 .29 1SG2395
ATOM 2395 CDl PHE 306 67. .551 32 .867 23. .993 1, .00 62. .29 1SG2396
ATOM 2396 CD2 PHE 306 69 .338 32 .327 25 .464 1 .00 62 .29 1SG2397
ATOM 2397 CE1 PHE 306 68, .446 33, .484 23, .152 1, .00 62. .29 1SG2398
ATOM 2398 CE2 PHE 306 70 .235 32 .941 24, .630 1 .00 62 .29 1SG2399
ATOM 2399 CZ PHE 306 69. .783 33, .518 23, .473 1, .00 62. .29 1SG2400
ATOM 2400 C PHE 306 68 .039 29 .680 24, .936 1, .00 62. .29 1SG2401
ATOM 2401 O PHE 306 68 .958 29 .106 25, .520 1 .00 62 .29 1SG2402
ATOM 2402 N VAL 307 68, .009 29, .906 23, .619 1, .00 54 .26 1SG2403
ATOM 2403 CA VAL 307 6 .093 29 .624 22, .746 1 .00 54 .26 1SG2404
ATOM 2404 CB VAL 307 68, .986 28, .305 22. .038 1, .00 54, .26 1SG2405
ATOM 2405 CGI VAL 307 67, .735 28 .324 21, .147 1. .00 54 .26 1SG2406
ATOM 2406 CG2 VAL 307 70, .292 28 .061 21, .264 1, .00 54, .26 1SG2407
ATOM 2407 C VAL 307 69, .037 30, .706 21. .721 1, .00 54, .26 1SG2408
ATOM 2408 O VAL 307 67 .991 31 .323 21, .518 1 .00 54 .26 1SG2409
ATOM 2409 N ALA 308 70, .174 30, .988 21. .064 1, .00 44, .38 1SG2410
ATOM 2410 CA ALA 308 70, .198 32 .025 20. .072 1, .00 44, .38 1SG2411
ATOM 2411 CB ALA 308 70, .459 33, .437 20. .618 1. .00 44, .38 1SG2412
ATOM 2412 C ALA 308 71, .335 31, .730 19. .154 1, .00 44, .38 1SG2413
ATOM 2413 O ALA 308 71, .960 30, .676 19. .249 1, .00 44, .38 1SG2414
ATOM 2414 N SER 309 71, .588 32, .653 18. .204 1, .00 36, .40 1SG2415
ATOM 2415 CA SER 309 72, .688 32, .539 17. .290 1, .00 36, .40 1SG2416
ATOM 2416 CB SER 309 72. .245 32. .380 15. .826 1. .00 36. .40 1SG2417
ATOM 2417 OG SER 309 73. .378 32. .271 14. .977 1. .00 36, .40 1SG2418
ATOM 2418 C SER 309 73. .436 33. .831 17. .401 1. .00 36. .40 1SG2419
ATOM 2419 O SER 309 72. .831 34. .886 17. .592 1. .00 36. .40 1SG2420
ATOM 2420 N THR 310 74. .780 33, .788 17. .300 1. .00 31. .60 1SG2421
ATOM 2421 CA THR 310 75. .528 34, .997 17. .495 1. .00 31. .60 1SG2422
ATOM 2422 CB THR 310 76. .072 35, .085 18. .886 1. .00 31. .60 1SG2423
ATOM 2423 OGl THR 310 77. .009 34. .041 19. .113 1. .00 31. ,60 1SG2424
ATOM 2424 CG2 THR 310 74. .896 34. .954 19. .865 1. .00 31. .60 1SG2425
ATOM 2425 C THR 310 76. .710 35. .007 16. .580 1. .00 31. ,60 1SG2426
ATOM 2426 0 THR 310 77. .076 33. .990 15. .994 1. .00 31. .60 1SG2427
ATOM 2427 N SER 311 77. .350 36. .186 16. .445 1. .00 28. .31 1SG2428
ATOM 2428 CA SER 311 78. .513 36. ,286 15. ,617 1. ,00 28. .31 1SG2429 ATOM 2429 CB SER 311 78.515 37.521 14.700 1.00 28.31 1SG2430
ATOM 2430 OG SER 311 77. 445 37. 442 13. 769 1. 00 28. .31 1SG2431
ATOM 2431 C SER 311 79. 683 36. ,416 16. .532 1. 00 28. 31 1SG2432
ATOM 2432 O SER 311 79. .617 37. 115 17. 543 1. .00 28. .31 1SG2433
ATOM 2433 N VAL 312 80. 789 35. .716 16. .211 1. 00 27. .02 1SG2434
ATOM 2434 CA VAL 312 81. ,945 35. .827 17. 047 1. 00 27. .02 1SG2435
ATOM 2435 CB VAL 312 82. ,465 34. ,503 17. .523 1. .00 27. .02 1SG2436
ATOM 2436 CGI VAL 312 83. .757 34. .744 18. .323 1. .00 27. .02 1SG2437
ATOM 2437 CG2 VAL 312 81. ,356 33. .801 18. .326 1. .00 27. .02 1SG2438
ATOM 2438 C VAL 312 83. ,023 36. .459 16. ,226 1. .00 27. .02 1SG2439
ATOM 2439 O VAL 312 83. 510 35. 868 15. ,263 1. .00 27. .02 1SG2440
ATOM 2440 N GLY 313 83. .417 37. 698 16. 583 1. 00 28. ,22 1SG2441
ATOM 2441 CA GLY 313 84. .465 38. 360 15. ,860 1. .00 28. .22 1SG2442
ATOM 2442 C GLY 313 85. .765 37. .932 16. 462 1. .00 28. .22 1SG2443
ATOM 2443 O GLY 313 85, .829 37. 611 17. .648 1. .00 28. .22 1SG2444
ATOM 2444 N LEU 314 86. .850 37. .937 15. .659 1. .00 31. .63 1SG2445
ATOM 2445 CA LEU 314 88. ,126 37. 544 16. .187 1. .00 31. .63 1SG2446
ATOM 2446 CB LEU 314 88. .568 36. ,148 15. ,699 1. .00 31. .63 1SG2447
ATOM 2447 CG LEU 314 89. .886 35. ,618 16. ,305 1. .00 31. .63 1SG2448
ATOM 2448 CD2 LEU 314 89. ,806 35. .585 17. .840 1. .00 31. .63 1SG2449
ATOM 2449 CDl LEU 314 91, .124 36. .370 15. .788 1. .00 31 .63 1SG2450
ATOM 2450 C LEU 314 89, .147 38. .546 15. .739 1. .00 31. .63 1SG2451
ATOM 2451 O LEU 314 89. .199 38. .917 14. .566 1. .00 31. .63 1SG2452
ATOM 2452 N VAL 315 89, .997 39, .000 16. .685 1. .00 34. .47 1SG2453
ATOM 2453 CA VAL 315 91. .019 39. .970 16. .403 1. .00 34 .47 1SG2454
ATOM 2454 CB VAL 315 90. ,580 41. .365 16. .765 1. .00 34. .47 1SG2455
ATOM 2455 CGI VAL 315 91. .696 42. .376 16. .452 1. .00 34 .47 1SG2456
ATOM 2456 CG2 VAL 315 89, ,265 41. .652 16. .022 1, .00 34 .47 1SG2457
ATOM 2457 C VAL 315 92, .194 39. .601 17. .261 1. .00 34 .47 1SG2458
ATOM 2458 O VAL 315 92, .076 38. .755 18, .146 1. .00 34 .47 1SG2459
ATOM 2459 N ILE 316 93, .380 40. .193 17. .007 1. .00 38 .46 1SG2460
ATOM 2460 CA ILE 316 94, .510 39. .845 17, .820 1 .00 38 .46 1SG2461
ATOM 2461 CB ILE 316 95 .553 39. .040 17, .086 1, .00 38 .46 1SG2462
ATOM 2462 CG2 ILE 316 94, .887 37. .719 16 .665 1 .00 38 .46 1SG2463
ATOM 2463 CGI ILE 316 96 .176 39. .811 15. .907 1, .00 38 .46 1SG2464
ATOM 2464 CDl ILE 316 97, .216 40, ,858 16 .307 1 .00 38 .46 1SG2465
ATOM 2465 C ILE 316 95 .134 41, .082 18 .385 1 .00 38 .46 1SG2466
ATOM 2466 O ILE 316 95 .241 42, .114 17 .723 1 .00 38 .46 1SG2467
ATOM 2467 N LEU 317 95 .524 41 .000 19 .671 1 .00 40 .60 1SG2468
ATOM 2468 CA LEU 317 96 .203 42, .056 20. .357 1 .00 40 .60 1SG2469
ATOM 2469 CB LEU 317 95 .403 42 .643 21 .530 1 .00 40 .60 1SG2470
ATOM 2470 CG LEU 317 96 .143 43, .778 22 .263 1 .00 40 .60 1SG2471
ATOM 2471 CD2 LEU 317 95 .441 44 .143 23 .581 1 .00 40 .60 1SG2472
ATOM 2472 CDl LEU 317 96 .364 44 .989 21 .344 1 .00 40 .60 1SG2473
ATOM 2473 C LEU 317 97 .415 41 .417 20 .938 1 .00 40 .60 1SG2474
ATOM 2474 O LEU 317 97 .318 40 .373 21 .582 1 .00 40 .60 1SG2475
ATOM 2475 N GLY 318 98 .598 42 .017 20 .715 1 .00 42 .58 1SG2476
ATOM 2476 CA GLY 318 99 .778 41 .401 21 .236 1 .00 42 .58 1SG2477
ATOM 2477 C GLY 318 99 .853 40 .043 20 .607 1 .00 42 .58 1SG2478
ATOM 2478 O GLY 318 99 .735 39 .891 19 .393 1 .00 42 .58 1SG2479
ATOM 2479 N GLN 319 100 .142 39 .036 21 .449 1 .00 46 .59 1SG2480
ATOM 2480 CA GLN 319 100 .222 37 .629 21 .160 1 .00 46 .59 1SG2481
ATOM 2481 CB GLN 319 101 .116 36 .876 22 .158 1 .00 46 .59 1SG2482
ATOM 2482 CG GLN 319 102 .584 37 .299 22 .099 1 .00 46 .59 1SG2483
ATOM 2483 CD GLN 319 103 .350 36 .484 23 .130 1 .00 46 .59 1SG2484
ATOM 2484 OEl GLN 319 102 .776 35 .658 23 .839 1 .00 46 .59 1SG2485
ATOM 2485 NE2 GLN 319 104, .686 36, .720 23. .218 1 .00 46 .59 1SG2486 ATOM 2486 C GLN 319 98,.876 36,.947 21..183 1..00 46,.59 1SG2487
ATOM 2487 O GLN 319 98. .747 35. .822 20. .699 1. .00 46, .59 1SG2488
ATOM 2488 N ARG 320 97. .881 37, .561 21. .859 1. .00 48, .03 1SG2489
ATOM 2489 CA ARG 320 96. .619 36, .929 22. .172 1. .00 48 .03 1SG2490
ATOM 2490 CB ARG 320 95. .906 37. .582 23. .366 1. ,00 48, .03 1SG2491
ATOM 2491 CG ARG 320 96. .728 37, .547 24, .653 1. .00 48, .03 1SG2492
ATOM 2492 CD ARG 320 95. .992 38, .144 25 .853 1. .00 48 .03 1SG2493
ATOM 2493 NE ARG 320 95 .639 39. .550 25 .507 1. .00 48 .03 1SG2494
ATOM 2494 CZ ARG 320 96. .531 40. .557 25, .738 1. .00 48, .03 1SG2495
ATOM 2495 NHl ARG 320 97. .756 40, .276 26, .269 1. .00 48, .03 1SG2496
ATOM 2496 NH2 ARG 320 96 .199 41, .846 25 .435 1. .00 48 .03 1SG2497
ATOM 2497 C ARG 320 95, .611 36. .892 21, .061 1. .00 48, .03 1SG2498
ATOM 2498 O ARG 320 95, .645 37. .671 20, .111 1. .00 48, .03 1SG2499
ATOM 2499 N LEU 321 94 .668 35. .928 21 .197 1. .00 48 .48 1SG2500
ATOM 2500 CA LEU 321 93 .556 35, .719 20 .313 1. .00 48 .48 1SG2501
ATOM 2501 CB LEU 321 93, .378 34, .225 19, .963 1. .00 48, .48 1SG2502
ATOM 2502 CG LEU 321 92, .251 33, .895 18, .964 1. .00 48 .48 1SG2503
ATOM 2503 CD2 LEU 321 91 .993 32 .377 18 .899 1, .00 48 .48 1SG2504
ATOM 2504 CDl LEU 321 92, .538 34, .500 17, .580 1. .00 48, .48 1SG2505
ATOM 2505 C LEU 321 92 .362 36, .173 21, .101 1. .00 48 .48 1SG2506
ATOM 2506 O LEU 321 92 .004 35, .561 22 .106 1. .00 48 .48 1SG2507
ATOM 2507 N VAL 322 91 .717 37 .276 20 .669 1, .00 48 .32 1SG2508
ATOM 2508 CA VAL 322 90, .625 37. .822 21, .425 1. .00 48 .32 1SG2509
ATOM 2509 CB VAL 322 90, .905 39. .221 21 .896 1. .00 48 .32 1SG2510
ATOM 2510 CGI VAL 322 89 .658 39 .762 22 .585 1, .00 48 .32 1SG2511
ATOM 2511 CG2 VAL 322 92, .124 39, .206 22, .827 1. .00 48 .32 1SG2512
ATOM 2512 C VAL 322 89, .420 37, .868 20, .541 1. .00 48 .32 1SG2513
ATOM 2513 O VAL 322 89 .541 37, .934 19 .319 1. .00 48 .32 1SG2514
ATOM 2514 N CYS 323 88 .213 37 .807 21 .143 1. .00 45 .78 1SG2515
ATOM 2515 CA CYS 323 87, .023 37, .830 20, .343 1. .00 45 .78 1SG2516
ATOM 2516 CB CYS 323 86 .477 36, .426 20, .036 1. .00 45 .78 1SG2517
ATOM 2517 SG CYS 323 85 .948 35 .546 21 .537 1. .00 45 .78 1SG2518
ATOM 2518 C CYS 323 85, .940 38. .555 21, .078 1. .00 45, .78 1SG2519
ATOM 2519 O CYS 323 86, .097 38. .932 22, .238 1. .00 45 .78 1SG2520
ATOM 2520 N SER 324 84 .803 38, .783 20, .383 1. .00 45 .62 1SG2521
ATOM 2521 CA SER 324 83 .666 39 .418 20 .985 1. .00 45 .62 1SG2522
ATOM 2522 CB SER 324 83, .498 40, .900 20, .605 1. .00 45 .62 1SG2523
ATOM 2523 OG SER 324 82, .352 41, .440 21, .245 1. .00 45 .62 1SG2524
ATOM 2524 C SER 324 82 .457 38, .676 20, .504 1. .00 45 .62 1SG2525
ATOM 2525 O SER 324 82, .434 38. .137 19. .398 1. .00 45, .62 1SG2526
ATOM 2526 N LEU 325 81. .414 38. .626 21. .352 1. ,00 46, .68 1SG2527
ATOM 2527 CA LEU 325 80. .218 37. .886 21. .070 1. .00 46, .68 1SG2528
ATOM 2528 CB LEU 325 79 .849 37. .016 22. .290 1. .00 46 .68 1SG2529
ATOM 2529 CG LEU 325 78, .733 35. .970 22. .107 1. .00 46, .68 1SG2530
ATOM 2530 CD2 LEU 325 77, .438 36, .566 21. .539 1. .00 46, .68 1SG2531
ATOM 2531 CDl LEU 325 78, .501 35, .208 23. .421 1. .00 46, .68 1SG2532
ATOM 2532 C LEU 325 79. .118 38. .890 20. .872 1. ,00 46. .68 1SG2533
ATOM 2533 O LEU 325 78, .998 39, .840 21, .644 1. ,00 46. .68 1SG2534
ATOM 2534 N SER 326 78, .294 38. .709 19, .816 1. .00 46. .14 1SG2535
ATOM 2535 CA SER 326 77, .175 39, .584 19. .580 1. .00 46, .14 1SG2536
ATOM 2536 CB SER 326 77. .334 40. .457 18. .323 1. ,00 46. .14 1SG2537
ATOM 2537 OG SER 326 78. .434 41. .342 18. .479 1. ,00 46, .14 1SG2538
ATOM 2538 C SER 326 75. .986 38. .700 19. .360 1. ,00 46, .14 1SG2539
ATOM 2539 O SER 326 76. .027 37. .794 18. .532 1. ,00 46. .14 1SG2540
ATOM 2540 N LEU 327 74. .890 38. ,951 20. .104 1. ,00 46. .81 1SG2541
ATOM 2541 CA LEU 327 73. .725 38. .106 20. .074 1. .00 46. .81 1SG2542
ATOM 2542 CB LEU 327 72. .981 38. .054 21. .424 1. ,00 46. .81 1SG2543 ATOM 2543 CG LEU 327 73.812 37,.565 22,.628 1,.00 46,.81 1SG2544
ATOM 2544 CD2 LEU 327 75 .007 38, .490 22, .892 1, .00 46, .81 1SG2545
ATOM 2545 CDl LEU 327 74 .219 36, .092 22, .497 1 .00 46, .81 1SG2546
ATOM 2546 C LEU 327 72 .718 38. .605 19, .087 1, .00 46, .81 1SG2547
ATOM 2547 O LEU 327 72 .766 39 .744 18 .624 1 .00 46 .81 1SG2548
ATOM 2548 N ASN 328 71 .755 37. .720 18, .766 1, .00 45, .61 1SG2549
ATOM 2549 CA ASN 328 70 .670 38. .011 17, .879 1, .00 45, .61 1SG2550
ATOM 2550 CB ASN 328 70 .560 37. .024 16. .706 1 .00 45. .61 1SG2551
ATOM 2551 CG ASN 328 69 .729 37, .695 15. .625 1, .00 45. .61 1SG2552
ATOM 2552 ODl ASN 328 70 .134 38 .721 15 .082 1 .00 45. .61 1SG2553
ATOM 2553 ND2 ASN 328 68 .545 37, .108 15, .302 1, .00 45. ,61 1SG2554
ATOM 2554 C ASN 328 69 .433 37 .876 18, .716 1 .00 45. .61 1SG2555
ATOM 2555 O ASN 328 69 .498 37, .986 19, .940 1, .00 45, .61 1SG2556
ATOM 2556 N ARG 329 68 .265 37, .656 18, .083 1, .00 45, ,52 1SG2557
ATOM 2557 CA ARG 329 67 .040 37 .544 18, .826 1, .00 45, .52 1SG2558
ATOM 2558 CB ARG 329 65 .799 37, .361 17, .936 1, .00 45, .52 1SG2559
ATOM 2559 CG ARG 329 64 .493 37 .245 18, .722 1, .00 45 .52 1SG2560
ATOM 2560 CD ARG 329 64 .092 38, .541 19, .430 1, .00 45, .52 1SG2561
ATOM 2561 NE ARG 329 62. .812 38, .284 20, .149 1, .00 45, .52 1SG2562
ATOM 2562 CZ ARG 329 61 .620 38, .496 19 .517 1 .00 45, .52 1SG2563
ATOM 2563 NHl ARG 329 61 .601 38, .944 18, .227 1, .00 45, .52 1SG2564
ATOM 2564 NH2 ARG 329 60 .448 38 .259 20 .175 1 .00 45 .52 1SG2565
ATOM 2565 C ARG 329 67 .151 36, .350 19, .723 1, .00 45, .52 1SG2566
ATOM 2566 O ARG 329 67 .848 35 .387 19 .410 1 .00 45 .52 1SG2567
ATOM 2567 N PHE 330 66 .469 36, .399 20, .888 1 .00 45 .81 1SG2568
ATOM 2568 CA PHE 330 66. .557 35, .337 21, .848 1, .00 45, .81 1SG2569
ATOM 2569 CB PHE 330 66 .635 35, .858 23 .293 1 .00 45 .81 1SG2570
ATOM 2570 CG PHE 330 67. .779 36, .811 23, .384 1, .00 45, .81 1SG2571
ATOM 2571 CDl PHE 330 69 .061 36. .370 23 .613 1 .00 45 .81 1SG2572
ATOM 2572 CD2 PHE 330 67 .561 38, .163 23, .240 1, .00 45, .81 1SG2573
ATOM 2573 CE1 PHE 330 70 .107 37, .259 23, .695 1, .00 45, .81 1SG2574
ATOM 2574 CE2 PHE 330 68 .602 39, .058 23, .321 1, .00 45 .81 1SG2575
ATOM 2575 CZ PHE 330 69, .879 38. .606 23. .549 1. .00 45, .81 1SG2576
ATOM 2576 C PHE 330 65 .289 34. .545 21, .761 1, .00 45, .81 1SG2577
ATOM 2577 O PHE 330 64, .209 35. .106 21. .584 1, .00 45, .81 1SG2578
ATOM 2578 N ARG 331 65 .386 33. .203 21, .877 1, .00 46, .00 1SG2579
ATOM 2579 CA ARG 331 64, .186 32 , .419 21. .812 1, .00 46. ,00 1SG2580
ATOM 2580 CB ARG 331 64 , .196 31. .318 20. .736 1. .00 46. .00 1SG2581
ATOM 2581 CG ARG 331 65. .298 30, .273 20, .897 1, .00 46, .00 1SG2582
ATOM 2582 CD ARG 331 65. .264 29. .202 19. .804 1. .00 46. .00 1SG2583
ATOM 2583 NE ARG 331 63 .995 28, .439 19, .964 1, .00 46, .00 1SG2584
ATOM 2584 CZ ARG 331 63. .622 27. .527 19. .019 1. .00 46. .00 1SG2585
ATOM 2585 NHl ARG 331 64, .412 27, .314 17. .927 1, .00 46. .00 1SG2586
ATOM 2586 NH2 ARG 331 62. .459 26. .828 19. .167 1. .00 46. .00 1SG2587
ATOM 2587 C ARG 331 63. .987 31. ,777 23. .145 1. .00 46. .00 1SG2588
ATOM 2588 O ARG 331 64. .921 31. .241 23. .740 1. .00 46. .00 1SG2589
ATOM 2589 N LEU 332 62. .738 31. .831 23. .650 1. .00 46. .81 1SG2590
ATOM 2590 CA LEU 332 62. .433 31. .321 24. .951 1. .00 46. .81 1SG2591
ATOM 2591 CB LEU 332 61. .490 32. .223 25. .763 1. .00 46. ,81 1SG2592
ATOM 2592 CG LEU 332 61, .858 33. ,715 25. .717 1. ,00 46. .81 1SG2593
ATOM 2593 CD2 LEU 332 61. .471 34. .335 24. .370 1. .00 46. ,81 1SG2594
ATOM 2594 CDl LEU 332 63. .324 33. .955 26. ,088 1. .00 46. ,81 1SG2595
ATOM 2595 C LEU 332 61. .672 30. .051 24. ,777 1. .00 46. ,81 1SG2596
ATOM 2596 O LEU 332 61. .024 29. .830 23. ,754 1. .00 46. ,81 1SG2597
ATOM 2597 N ALA 333 61. .759 29. .174 25. .795 1. .00 44. ,80 1SG2598
ATOM 2598 CA ALA 333 61. ,022 27. .947 25. ,813 1. .00 44. 80 1SG2599
ATOM 2599 CB ALA 333 61. ,840 26. 728 25. ,357 1. 00 44. 80 1SG2600 ATOM 2600 C ALA 333 60..660 27..728 27..247 1..00 44..80 1SG2601
ATOM 2601 O ALA 333 61. .402 28. .132 28. .141 1. .00 44, .80 1SG2602
ATOM 2602 N LEU 334 59. .499 27. .092 27. .500 1. .00 44. .05 1SG2603
ATOM 2603 CA LEU 334 59. .037 26. .848 28. .839 1. .00 44. .05 1SG2604
ATOM 2604 CB LEU 334 57. .515 27. .074 28. .961 1. .00 44. .05 1SG2605
ATOM 2605 CG LEU 334 56. .890 26. .787 30. .342 1. .00 44. .05 1SG2606
ATOM 2606 CD2 LEU 334 55. ,368 26. .614 30, .229 1. .00 44. .05 1SG2607
ATOM 2607 CDl LEU 334 57. .286 27. .833 31. .394 1. .00 44, .05 1SG2608
ATOM 2608 C LEU 334 59, .276 25. .401 29. .159 1. .00 44. .05 1SG2609
ATOM 2609 O LEU 334 58. .585 24. .532 28. .631 1. .00 44. .05 1SG2610
ATOM 2610 N PRO 335 60. .295 25. .107 29 .928 1. .00 45. .03 1SG2611
ATOM 2611 CA PRO 335 60, .505 23. .746 30. .356 1. .00 45 .03 1SG2612
ATOM 2612 CD PRO 335 61, .558 25. .799 29 .724 1, .00 45, .03 1SG2613
ATOM 2613 CB PRO 335 61. .969 23, .653 30, .777 1, .00 45, .03 1SG2614
ATOM 2614 CG PRO 335 62. .656 24. .745 29 .942 1. .00 45, .03 1SG2615
ATOM 2615 C PRO 335 59. .558 23. .214 31, .394 1. .00 45, .03 1SG2616
ATOM 2616 0 PRO 335 59, .085 22. .089 31 .238 1, .00 45, .03 1SG2617
ATOM 2617 N GLU 336 59, .273 23. .996 32, .459 1. .00 48, .25 1SG2618
ATOM 2618 CA GLU 336 58. .414 23. .545 33, .522 1. .00 48 .25 1SG2619
ATOM 2619 CB GLU 336 59. .073 22. .518 34, .460 1. .00 48, .25 1SG2620
ATOM 2620 CG GLU 336 59. .352 21. .163 33, .807 1. .00 48 .25 1SG2621
ATOM 2621 CD GLU 336 60. .001 20. .265 34, .851 1. .00 48, .25 1SG2622
ATOM 2622 OEl GLU 336 60. .942 20. .742 35, .540 1. .00 48, .25 1SG2623
ATOM 2623 OE2 GLU 336 59. ,559 19, .092 34, .976 1, .00 48, .25 1SG2624
ATOM 2624 C GLU 336 58. .092 24. .739 34, .362 1. .00 48, .25 1SG2625
ATOM 2625 0 GLU 336 58, ,885 25. .677 34, .447 1. .00 48, .25 1SG2626
ATOM 2626 N SER 337 56. .907 24. .745 35 .009 1, .00 54 .26 1SG2627
ATOM 2627 CA SER 337 56. .584 25 .890 35 .804 1, .00 5 .26 1SG2628
ATOM 2628 CB SER 337 55, .685 26. .889 35 .060 1, .00 54 .26 1SG2629
ATOM 2629 OG SER 337 55. .399 28, .000 35 .893 1, .00 54 .26 1SG2630
ATOM 2630 C SER 337 55. .838 25, .444 37, .019 1. .00 54 .26 1SG2631
ATOM 2631 0 SER 337 54. .900 24. .654 36 .937 1. .00 54 .26 1SG2632
ATOM 2632 N ASN 338 56. .270 25, .929 38, .197 1, .00 60 .88 1SG2633
ATOM 2633 CA ASN 338 55. ,599 25. .633 39 .436 1, .00 60 .88 1SG2634
ATOM 2634 CB ASN 338 56. .426 25, .889 40, .747 1. .00 60 .88 1SG2635
ATOM 2635 CG ASN 338 56. .797 27, .365 40 .981 1, .00 60 .88 1SG2636
ATOM 2636 ODl ASN 338 57, ,368 26, .399 40, .483 1. .00 60. .88 1SG2637
ATOM 2637 ND2 ASN 338 55. .669 27. .645 41 .686 1. .00 60. .88 1SG2638
ATOM 2638 C ASN 338 54. ,332 26. .436 39, .484 1. .00 60. .88 1SG2639
ATOM 2639 0 ASN 338 53. .318 25. .993 40, .019 1, .00 60, .88 1SG2640
ATOM 2640 N ARG 339 54. .396 27. .671 38, .947 1. .00 63, .46 1SG2641
ATOM 2641 CA ARG 339 53. .334 28. .637 38 .978 1 .00 63 .46 1SG2642
ATOM 2642 CB ARG 339 53. .784 30. .067 38 .615 1. .00 63, .46 1SG2643
ATOM 2643 CG ARG 339 54. .374 30, .219 37, .215 1. .00 63 .46 1SG2644
ATOM 2644 CD ARG 339 55. .043 31 .574 36 .978 1. .00 63, .46 1SG2645
ATOM 2645 NE ARG 339 55, .652 31. .541 35, .618 1. .00 63, .46 1SG2646
ATOM 2646 CZ ARG 339 56. .782 32 .262 35, .361 1. .00 63, .46 1SG2647
ATOM 2647 NHl ARG 339 57. .352 33, .012 36, .348 1. .00 63, .46 1SG2648
ATOM 2648 NH2 ARG 339 57. .342 32, .231 34, .116 1, .00 63, .46 1SG2649
ATOM 2649 C ARG 339 52. .166 28, .269 38, .119 1. .00 63, .46 1SG2650
ATOM 2650 0 ARG 339 51. .068 28. .728 38 .409 1. .00 63, .46 1SG2651
ATOM 2651 N SER 340 52. .379 27. .534 37, .008 1. .00 60. .71 1SG2652
ATOM 2652 CA SER 340 51. .363 27. .052 36, .095 1. .00 60, .71 1SG2653
ATOM 2653 CB SER 340 49. .925 27. .594 36, .237 1. .00 60. .71 1SG2654
ATOM 2654 OG SER 340 49. ,900 28. .988 35. .969 1. .00 60, .71 1SG2655
ATOM 2655 C SER 340 51. .807 27. .449 34. .735 1. ,00 60 . .71 1SG2656
ATOM 2656 0 SER 340 52. .816 28, .134 34. .582 1, .00 60 .71 1SG2657 ATOM 2657 N ASN 341 51..051 27,.030 33..705 1..00 55,.60 1SG2658
ATOM 2658 CA ASN 341 51. .435 27, .363 32, .367 1. .00 55, .60 1SG2659
ATOM 2659 CB ASN 341 50, .733 26, .510 31. .296 1. .00 55, .60 1SG2660
ATOM 2660 CG ASN 341 51, .327 26, .874 29. .943 1. .00 55. .60 1SG2661
ATOM 2661 ODl ASN 341 52, .517 26, .681 29. .701 1. .00 55. .60 1SG2662
ATOM 2662 ND2 ASN 341 50, .475 27, .416 29. .032 1. .00 55. .60 1SG2663
ATOM 2663 C ASN 341 51, .080 28, .792 32. .114 1. .00 55. .60 1SG2664
ATOM 2664 O ASN 341 50 .004 29 .256 32. .488 1, .00 55, .60 1SG2665
ATOM 2665 N ILE 342 52 .007 29, .532 31. .477 1, .00 49, .07 1SG2666
ATOM 2666 CA ILE 342 51 .769 30, .900 31. .133 1. .00 49, .07 1SG2667
ATOM 2667 CB ILE 342 52 .273 31, .884 32. .146 1. .00 49, .07 1SG2668
ATOM 2668 CG2 ILE 342 53 .810 31, .830 32, .152 1. .00 49, .07 1SG2669
ATOM 2669 CGI ILE 342 51, .689 33, .276 31, .854 1. .00 49, .07 1SG2670
ATOM 2670 CDl ILE 342 51, .837 34, .256 33. .013 1. .00 49, .07 1SG2671
ATOM 2671 C ILE 342 52, .461 31, .174 29. .836 1. .00 49. .07 1SG2672
ATOM 2672 O ILE 342 53 .236 30 .356 29. .341 1. .00 49. .07 1SG2673
ATOM 2673 N GLU 343 52 .172 32 .340 29. .229 1. .00 44. .46 1SG2674
ATOM 2674 CA GLU 343 52 .796 32 .645 27, .975 1, .00 44, .46 1SG2675
ATOM 2675 CB GLU 343 52, .215 33, .896 27. .294 1. .00 44, .46 1SG2676
ATOM 2676 CG GLU 343 52, .707 34. .099 25. .859 1. .00 44, .46 1SG2677
ATOM 2677 CD GLU 343 51, .987 33, .090 24, .975 1. .00 44, .46 1SG2678
ATOM 2678 OEl GLU 343 51, .259 32, .227 25, .536 1. .00 44, .46 1SG2679
ATOM 2679 OE2 GLU 343 52 .153 33, .168 23 .729 1. .00 44 .46 1SG2680
ATOM 2680 C GLU 343 54 .250 32, .892 28, .237 1, .00 44, .46 1SG2681
ATOM 2681 O GLU 343 54, .631 33, .774 29, .003 1. .00 44, .46 1SG2682
ATOM 2682 N VAL 344 55, .105 32, .104 27, .564 1, .00 43, .58 1SG2683
ATOM 2683 CA VAL 344 56, .533 32 , .171 27, .685 1. .00 43, .58 1SG2684
ATOM 2684 CB VAL 344 57, .242 31, .138 26, .861 1. .00 43, .58 1SG2685
ATOM 2685 CGI VAL 344 58, .753 31, .384 26, .982 1. .00 43, .58 1SG2686
ATOM 2686 CG2 VAL 344 56, .812 29. .741 27, .324 1. .00 43, .58 1SG2687
ATOM 2687 C VAL 344 56 .993 33. .501 27, .176 1. .00 43 .58 1SG2688
ATOM 2688 O VAL 344 58, .063 33. .980 27, .545 1. .00 43 .58 1SG2689
ATOM 2689 N LEU 345 56, .196 34. .099 26, .275 1, .00 43 .36 1SG2690
ATOM 2690 CA LEU 345 56, .482 35. .327 25, .583 1. .00 43, .36 1SG2691
ATOM 2691 CB LEU 345 55, .398 35. .686 24, .552 1. .00 43, .36 1SG2692
ATOM 2692 CG LEU 345 55. .285 34. .675 23. .395 1. .00 43, .36 1SG2693
ATOM 2693 CD2 LEU 345 54. .891 33. .279 23. .904 1. .00 43, .36 1SG2694
ATOM 2694 CDl LEU 345 56, .560 34. .660 22. .538 1, .00 43 , .36 1SG2695
ATOM 2695 C LEU 345 56, .599 36. .492 26. .525 1. .00 43, .36 1SG2696
ATOM 2696 O LEU 345 57. .320 37. .444 26. .234 1. .00 43, .36 1SG2697
ATOM 2697 N ARG 346 55. .882 36. .474 27, .662 1. .00 43, .36 1SG2698
ATOM 2698 CA ARG 346 55. .854 37. .597 28. .564 1. .00 43 , .36 1SG2699
ATOM 2699 CB ARG 346 54. .920 37. .367 29. .764 1. ,00 43. .36 1SG2700
ATOM 2700 CG ARG 346 53. .448 37. .267 29. .356 1. ,00 43. .36 1SG2701
ATOM 2701 CD ARG 346 52. .484 37. .038 30. ,522 1. ,00 43. .36 1SG2702
ATOM 2702 NE ARG 346 51. .110 36. .967 29. .948 1. .00 43. .36 1SG2703
ATOM 2703 CZ ARG 346 50. .043 36. .668 30. .745 1. .00 43. .36 1SG2704
ATOM 2704 NHl ARG 346 50. .228 36. .439 32. .078 1. ,00 43. .36 1SG2705
ATOM 2705 NH2 ARG 346 48. .790 36. .598 30. .209 1. ,00 43. .36 1SG2706
ATOM 2706 C ARG 346 57. .227 37. .911 29. , 094 1. ,00 43. .36 1SG2707
ATOM 2707 O ARG 346 57. .528 39. ,066 29. ,393 1. ,00 43. .36 1SG2708
ATOM 2708 N PHE 347 58. .073 36. ,880 29. ,259 1. ,00 47. ,69 1SG2709
ATOM 2709 CA PHE 347 59. .398 36. ,928 29. ,820 1. 00 47. ,69 1SG2710
ATOM 2710 CB PHE 347 59. .912 35. .509 30. .137 1. .00 47. .69 1SG2711
ATOM 2711 CG PHE 347 60. ,923 35. .575 31. .234 1. ,00 47. .69 1SG2712
ATOM 2712 CDl PHE 347 60. ,532 35. .950 32. .499 1. ,00 47. .69 1SG2713
ATOM 2713 CD2 PHE 347 62. ,236 35. .218 31. ,033 1. 00 47. ,69 1SG2714 ATOM 2714 CE1 PHE 347 61..438 36..007 33..532 1..00 47..69 1SG2715
ATOM 2715 CE2 PHE 347 63. .149 35, .272 32, .060 1. .00 47. .69 1SG2716
ATOM 2716 CZ PHE 347 62. .751 35, .671 33, .313 1. .00 47. .69 1SG2717
ATOM 2717 C PHE 347 60. .357 37. .620 28, .889 1. .00 47. .69 1SG2718
ATOM 2718 O PHE 347 61. .403 38. .102 29, .320 1. .00 47. .69 1SG2719
ATOM 2719 N GLU 348 60. .042 37, .665 27, .581 1. .00 50. .82 1SG2720
ATOM 2720 CA GLU 348 60. .947 38. .146 26, .570 1. .00 50. .82 1SG2721
ATOM 2721 CB GLU 348 60. .301 38. .215 25, .178 1. .00 50. .82 1SG2722
ATOM 2722 CG GLU 348 59. .933 36. .839 24 , .624 1. .00 50. .82 1SG2723
ATOM 2723 CD GLU 348 59. .368 37. .027 23, .226 1. .00 50, .82 1SG2724
ATOM 2724 OEl GLU 348 59. .348 38. .192 22, .750 1. .00 50, .82 1SG2725
ATOM 2725 OE2 GLU 348 58. .952 36. .007 22, .614 1. .00 50, .82 1SG2726
ATOM 2726 C GLU 348 61. .475 39. .513 26, .888 1. .00 50. .82 1SG2727
ATOM 2727 O GLU 348 62. .660 39. .766 26, .680 1. .00 50, .82 1SG2728
ATOM 2728 N ASN 349 60. .639 40, .439 27, .390 1. .00 54, .72 1SG2729
ATOM 2729 CA ASN 349 61. .145 41, .756 27, .659 1. .00 54, .72 1SG2730
ATOM 2730 CB ASN 349 60. .098 42, .704 28, .268 1. .00 54. .72 1SG2731
ATOM 2731 CG ASN 349 59, .056 43, .014 27 .205 1. .00 54. .72 1SG2732
ATOM 2732 ODl ASN 349 59, .387 43, .388 26, .081 1. .00 54, .72 1SG2733
ATOM 2733 ND2 ASN 349 57. .756 42, .851 27, .567 1. .00 54, .72 1SG2734
ATOM 2734 C ASN 349 62, .230 41, .660 28 .677 1, .00 54 .72 1SG2735
ATOM 2735 O ASN 349 63, .285 42, .274 28 .523 1. .00 54, .72 1SG2736
ATOM 2736 N ILE 350 62. .004 40, .894 29, .761 1. .00 59, .34 1SG2737
ATOM 2737 CA ILE 350 63. .026 40, .878 30, .759 1. .00 59. .34 1SG2738
ATOM 2738 CB ILE 350 62, .701 40, .216 32 .076 1. .00 59 .34 1SG2739
ATOM 2739 CG2 ILE 350 61, .402 40, .844 32, .574 1. .00 59. .34 1SG2740
ATOM 2740 CGI ILE 350 62. .663 38, .688 32, .023 1. .00 59. .34 1SG2741
ATOM 2741 CDl ILE 350 64. .053 38. .074 32, .199 1. .00 59. .34 1SG2742
ATOM 2742 C ILE 350 64, .230 40, .203 30 .184 1. .00 59 .34 1SG2743
ATOM 2743 O ILE 350 65. .350 40, .639 30, .436 1, .00 59. .34 1SG2744
ATOM 2744 N LEU 351 64. .044 39. .114 29, .399 1. .00 59, .01 1SG2745
ATOM 2745 CA LEU 351 65. .202 38, .415 28, .910 1. .00 59, .01 1SG2746
ATOM 2746 CB LEU 351 64. .999 37, .152 28, .042 1, .00 59 .01 1SG2747
ATOM 2747 CG LEU 351 64. .236 35, .976 28, .669 1. .00 59, .01 1SG2748
ATOM 2748 CD2 LEU 351 64. .958 34, .639 28, .437 1. .00 59, .01 1SG2749
ATOM 2749 CDl LEU 351 62. .761 35, .990 28. .247 1, .00 59 .01 1SG2750
ATOM 2750 C LEU 351 65. .993 39, .320 28. .027 1. .00 59, .01 1SG2751
ATOM 2751 O LEU 351 67. .216 39, .218 27, .971 1. .00 59, .01 1SG2752
ATOM 2752 N SER 352 65. .313 40, .198 27, .273 1. .00 58, .78 1SG2753
ATOM 2753 CA SER 352 65. .994 41, .050 26 .344 1, .00 58, .78 1SG2754
ATOM 2754 CB SER 352 65. .031 41, .929 25, .527 1. .00 58, .78 1SG2755
ATOM 2755 OG SER 352 65. .762 42. .747 24 , .626 1. .00 58. .78 1SG2756
ATOM 2756 C SER 352 66. .930 41. .961 27. .062 1. .00 58. .78 1SG2757
ATOM 2757 O SER 352 68. .005 42, .255 26. .552 1. .00 58, .78 1SG2758
ATOM 2758 N SER 353 66. .521 42, .487 28, .229 1. .00 58. .42 1SG2759
ATOM 2759 CA SER 353 67. .328 43. .386 29, .008 1. .00 58. .42 1SG2760
ATOM 2760 CB SER 353 66. .475 44. .115 30. .049 1. .00 58. .42 1SG2761
ATOM 2761 OG SER 353 65. .817 43, .146 30. .851 1. .00 58. .42 1SG2762
ATOM 2762 C SER 353 68. .425 42. .679 29. .751 1. .00 58. .42 1SG2763
ATOM 2763 O SER 353 69. .601 43. .023 29. .639 1. .00 58. .42 1SG2764
ATOM 2764 N ILE 354 68. .045 41, .646 30, .526 1. ,00 57, ,99 1SG2765
ATOM 2765 CA ILE 354 68. .915 40. .979 31. .449 1. .00 57. .99 1SG2766
ATOM 2766 CB ILE 354 68. .131 39. .961 32. .252 1. .00 57. .99 1SG2767
ATOM 2767 CG2 ILE 354 67. ,855 38. .727 31. .380 1. .00 57. .99 1SG2768
ATOM 2768 CGI ILE 354 68. .829 39. .603 33. .564 1. .00 57. .99 1SG2769
ATOM 2769 CDl ILE 354 70. .104 38. .803 33. .359 1. ,00 57. .99 1SG2770
ATOM 2770 C ILE 354 70. ,076 40. .359 30. .725 1. ,00 57. ,99 1SG2771 ATOM 2771 O ILE 354 71..222 40..512 31..145 1..00 57,.99 1SG2772
ATOM 2772 N LEU 355 69. .828 39. .668 29. .598 1. .00 55. .08 1SG2773
ATOM 2773 CA LEU 355 70. .898 38. .981 28. .934 1. .00 55. .08 1SG2774
ATOM 2774 CB LEU 355 70, .390 38. .140 27. .741 1. .00 55. .08 1SG2775
ATOM 2775 CG LEU 355 71, .457 37. .307 26. .994 1. .00 55, .08 1SG2776
ATOM 2776 CD2 LEU 355 72, .218 36, .393 27. .968 1. .00 55, .08 1SG2777
ATOM 2777 CDl LEU 355 72. .395 38, .168 26. .130 1. .00 55, .08 1SG2778
ATOM 2778 C LEU 355 71. .946 39, .933 28. .436 1. .00 55, .08 1SG2779
ATOM 2779 O LEU 355 73, .121 39, .783 28. .767 1. .00 55, .08 1SG2780
ATOM 2780 N HIS 356 71, .571 40, .945 27. .630 1. .00 51, .73 1SG2781
ATOM 2781 CA HIS 356 72, .601 41, .781 27. .084 1. .00 51, .73 1SG2782
ATOM 2782 NDl HIS 356 70, .014 43, .954 26. .182 1. .00 51, .73 1SG2783
ATOM 2783 CG HIS 356 71, .388 43, .885 26. .206 1. .00 51, .73 1SG2784
ATOM 2784 CB HIS 356 72, .176 42, .653 25. .884 1, .00 51, .73 1SG2785
ATOM 2785 NE2 HIS 356 70, .743 45, .988 26. .701 1. .00 51, .73 1SG2786
ATOM 2786 CD2 HIS 356 71. .817 45, .136 26. .528 1. .00 51, .73 1SG2787
ATOM 2787 CE1 HIS 356 69. .681 45. .233 26. .483 1, .00 51, .73 1SG2788
ATOM 2788 C HIS 356 73, .209 42, .655 28, .136 1. .00 51 .73 1SG2789
ATOM 2789 O HIS 356 74, .412 42 .902 28, .104 1. .00 51 .73 1SG2790
ATOM 2790 N PHE 357 72, .405 43 .211 29, .064 1. .00 48 .72 1SG2791
ATOM 2791 CA PHE 357 73, .010 44 .056 30. .055 1. .00 48 .72 1SG2792
ATOM 2792 CB PHE 357 72, .012 44, .789 30. .974 1. .00 48 .72 1SG2793
ATOM 2793 CG PHE 357 71, .323 45, .901 30. .261 1, .00 48 .72 1SG2794
ATOM 2794 CDl PHE 357 71, .940 47 .125 30. .133 1, .00 48 .72 1SG2795
ATOM 2795 CD2 PHE 357 70, .066 45 .731 29, .729 1. .00 48 .72 1SG2796
ATOM 2796 CE1 PHE 357 71, .315 48 .164 29, .485 1, .00 48 .72 1SG2797
ATOM 2797 CE2 PHE 357 69, .436 46, .767 29, .082 1. .00 48 .72 1SG2798
ATOM 2798 CZ PHE 357 70, .059 47 .986 28, .958 1. .00 48 .72 1SG2799
ATOM 2799 C PHE 357 73, .864 43 .271 31, .005 1. .00 48, .72 1SG2800
ATOM 2800 o PHE 357 75, .039 43, .580 31, .190 1, .00 48 .72 1SG2801
ATOM 2801 N GLY 358 73, .255 42 .284 31, .696 1. .00 44 .30 1SG2802
ATOM 2802 CA GLY 358 73, .945 41 .522 32, .701 1. .00 44 .30 1SG2803
ATOM 2803 C GLY 358 74, .854 40 .428 32 , .212 1, .00 44 .30 1SG2804
ATOM 2804 O GLY 358 76, .005 40 .347 32. .632 1, .00 44 .30 1SG2805
ATOM 2805 N VAL 359 74, .324 39, .517 31. .366 1, .00 42 .84 1SG2806
ATOM 2806 CA VAL 359 75, .009 38, .312 30. .961 1. .00 42 .84 1SG2807
ATOM 2807 CB VAL 359 74, .064 37, .308 30. .367 1. .00 42 .84 1SG2808
ATOM 2808 CGI VAL 359 74, .866 36, .062 29. .953 1. .00 42 .84 1SG2809
ATOM 2809 CG2 VAL 359 72, .946 37, .027 31. .387 1. .00 42 .84 1SG2810
ATOM 2810 C VAL 359 76, .134 38, .481 29. .980 1. .00 42, .84 1SG2811
ATOM 2811 O VAL 359 77, .252 38, .028 30. .217 1. .00 42, .84 1SG2812
ATOM 2812 N LEU 360 75, .868 39, .153 28. .848 1. .00 41, .20 1SG2813
ATOM 2813 CA LEU 360 76, .798 39, .209 27. .753 1. .00 41, .20 1SG2814
ATOM 2814 CB LEU 360 76, .231 40, .017 26. .565 1. .00 41, .20 1SG2815
ATOM 2815 CG LEU 360 76, .944 39, .846 25. .201 1. .00 41, .20 1SG2816
ATOM 2816 CD2 LEU 360 78, .473 39. .959 25. .283 1. .00 41. .20 1SG2817
ATOM 2817 CDl LEU 360 76, .342 40. .797 24. .155 1. .00 41, .20 1SG2818
ATOM 2818 C LEU 360 78. .075 39, .853 28. .197 1. .00 41, .20 1SG2819
ATOM 2819 O LEU 360 79. .148 39, .349 27. .870 1. .00 41, .20 1SG2820
ATOM 2820 N PRO 361 78. .028 40, .919 28. .948 1. .00 38, .99 1SG2821
ATOM 2821 CA PRO 361 79. .247 41, .588 29. .298 1. ,00 38, .99 1SG2822
ATOM 2822 CD PRO 361 76. .914 41, .852 28. ,886 1. .00 38. .99 1SG2823
ATOM 2823 CB PRO 361 78. .826 42. .886 29. .981 1. .00 38, .99 1SG2824
ATOM 2824 CG PRO 361 77. .487 43. .218 29. .297 1. .00 38, .99 1SG2825
ATOM 2825 C PRO 361 80. .242 40. .772 30. ,056 1. .00 38. .99 1SG2826
ATOM 2826 O PRO 361 81. .437 40. .975 29. ,848 1. ,00 38. .99 1SG2827
ATOM 2827 N LEU 362 79. .807 39. .867 30. ,948 1. ,00 36. .68 1SG2828 ATOM 2828 CA LEU 362 80.,778 39..097 31..667 1.,00 36..68 1SG2829
ATOM 2829 CB LEU 362 80. ,166 38. .236 32. .786 1. .00 36. .68 1SG2830
ATOM 2830 CG LEU 362 79. .649 39. .057 33. .981 1. ,00 36. .68 1SG2831
ATOM 2831 CD2 LEU 362 78. .574 40. .063 33. .547 1. .00 36. .68 1SG2832
ATOM 2832 CDl LEU 362 80. .808 39. .726 34. .739 1. .00 36. .68 1SG2833
ATOM 2833 C LEU 362 81. .485 38. ,180 30. .721 1. .00 36. ,68 1SG2834
ATOM 2834 0 LEU 362 82. .704 38. .035 30. .782 1. .00 36. ,68 1SG2835
ATOM 2835 N ALA 363 80. .726 37. .535 29. .815 1. .00 35. .06 1SG2836
ATOM 2836 CA ALA 363 81. .286 36. .560 28. .923 1. .00 35. .06 1SG2837
ATOM 2837 CB ALA 363 80. .218 35. .882 28, .048 1. ,00 35. .06 1SG2838
ATOM 2838 C ALA 363 82. .293 37. .168 27, .998 1. .00 35. .06 1SG2839
ATOM 2839 O ALA 363 83. .384 36. .628 27, .821 1. .00 35. .06 1SG2840
ATOM 2840 N ASN 364 81. .968 38. .318 27, .385 1. .00 35. .00 1SG2841
ATOM 2841 CA ASN 364 82. .883 38. .885 26, .440 1. .00 35. .00 1SG2842
ATOM 2842 CB ASN 364 82. .285 39, .925 25, .467 1. .00 35, .00 1SG2843
ATOM 2843 CG ASN 364 81. .617 41, .046 26 .226 1. .00 35. .00 1SG2844
ATOM 2844 ODl ASN 364 81. .134 40, .827 27 .332 1. .00 35. .00 1SG2845
ATOM 2845 ND2 ASN 364 81. .555 42. .259 25, .616 1. .00 35. .00 1SG2846
ATOM 2846 C ASN 364 84. .114 39, .389 27, .123 1. .00 35. .00 1SG2847
ATOM 2847 O ASN 364 85. .156 39. .528 26, .489 1. .00 35. .00 1SG2848
ATOM 2848 N ALA 365 84. .035 39. .698 28, .429 1. .00 34. .72 1SG2849
ATOM 2849 CA ALA 365 85. .196 40, .188 29, .115 1. .00 34, .72 1SG2850
ATOM 2850 CB ALA 365 84. .927 40. .483 30 .601 1. .00 34, .72 1SG2851
ATOM 2851 C ALA 365 86. .267 39, .141 29 .050 1. .00 34, .72 1ΞG2852
ATOM 2852 0 ALA 365 87. .435 39, .455 28 .834 1. .00 34, .72 1SG2853
ATOM 2853 N LYS 366 85. .903 37 .860 29 .252 1. .00 36, .38 1SG2854
ATOM 2854 CA LYS 366 86, .885 36 .816 29 .197 1, .00 36 .38 1SG2855
ATOM 2855 CB LYS 366 86, .337 35, .447 29 .625 1, .00 36 .38 1SG2856
ATOM 2856 CG LYS 366 87. .448 34, .427 29, .866 1. .00 36, .38 1SG2857
ATOM 2857 CD LYS 366 86. .980 33, .179 30, .611 1. .00 36, .38 1SG2858
ATOM 2858 CE LYS 366 88. .130 32, .295 31, .096 1. .00 36, .38 1SG2859
ATOM 2859 NZ LYS 366 88, .978 31, .891 29 .953 1. .00 36, .38 1SG2860
ATOM 2860 C LYS 366 87, .385 36, .686 27 .790 1. .00 36. .38 1SG2861
ATOM 2861 0 LYS 366 88, .580 36, .518 27 .552 1. .00 36. .38 1SG2862
ATOM 2862 N LEU 367 86, .463 36, .778 26 .816 1. .00 37 .28 1SG2863
ATOM 2863 CA LEU 367 86, .772 36, .625 25 .422 1. .00 37 .28 1SG2864
ATOM 2864 CB LEU 367 85, .528 36 .807 24 .535 1, .00 37 .28 1SG2865
ATOM 2865 CG LEU 367 84, .416 35 .775 24 .802 1, .00 37 .28 1SG2866
ATOM 2866 CD2 LEU 367 84, .955 34 .337 24 .719 1. .00 37 .28 1SG2867
ATOM 2867 CDl LEU 367 83, .207 36, .013 23, .883 1. .00 37. .28 1SG2868
ATOM 2868 C LEU 367 87, .739 37, .697 25, .037 1. .00 37. .28 1SG2869
ATOM 2869 0 LEU 367 88, .670 37, .461 24, .267 1. .00 37, .28 1SG2870
ATOM 2870 N GLN 368 87, .528 38, .920 25 .555 1. .00 38, .23 1SG2871
ATOM 2871 CA GLN 368 88, .393 40, .016 25 .235 1. .00 38, .23 1SG2872
ATOM 2872 CB GLN 368 87, .896 41. .387 25 .733 1. .00 38, .23 1SG2873
ATOM 2873 CG GLN 368 88, .008 41, .611 27, .239 1. .00 38, .23 1SG2874
ATOM 2874 CD GLN 368 89, .406 42, .164 27 .482 1. .00 38, .23 1SG2875
ATOM 2875 OEl GLN 368 90, .131 41, .720 28 .370 1. .00 38, .23 1SG2876
ATOM 2876 NE2 GLN 368 89, .801 43 .163 26 .648 1. .00 38, .23 1SG2877
ATOM 2877 C GLN 368 89, .729 39 .737 25 .849 1, .00 38, .23 1SG2878
ATOM 2878 0 GLN 368 90 .758 40 .151 25 .319 1. .00 38, .23 1SG2879
ATOM 2879 N GLN 369 89, .750 39. .045 27, .008 1. .00 38. .35 1SG2880
ATOM 2880 CA GLN 369 91. .006 38. .758 27, .641 1. .00 38. .35 1SG2881
ATOM 2881 CB GLN 36? 90. .855 37, .901 28, .911 1. .00 38, .35 1SG2882
ATOM 2882 CG GLN 369 90. .097 38, .600 30, .041 1. .00 38. .35 1SG2883
ATOM 2883 CD GLN 369 90, .028 37, .639 31, .219 1. .00 38. .35 1SG2884
ATOM 2884 OEl GLN 369 90, .521 36, .514 31, .147 1. .00 38. .35 1SG2885 ATOM 2885 NE2 GLN 369 89..402 38..092 32..338 1..00 38..35 1SG2886
ATOM 2886 C GLN 369 91. .774 37, .954 26. .648 1. .00 38, .35 1SG2887
ATOM 2887 O GLN 369 92. .955 38. .200 26. .408 1. .00 38. .35 1SG2888
ATOM 2888 N GLY 370 91. .090 36, .979 26. .023 1. .00 38, .17 1SG2889
ATOM 2889 CA GLY 370 91, .682 36, .221 24. .965 1. .00 38, .17 1SG2890
ATOM 2890 C GLY 370 92. .379 35, .016 25. .494 1, .00 38, .17 1SG2891
ATOM 2891 O GLY 370 92. .359 34, .726 26. .690 1, .00 38, .17 1SG2892
ATOM 2892 N PHE 371 93. .005 34 , .272 24. .558 1, .00 40. .04 1SG2893
ATOM 2893 CA PHE 371 93. .737 33, .089 24. .880 1, .00 40. .04 1SG2894
ATOM 2894 CB PHE 371 93, .142 31 .807 24, .272 1 .00 40 .04 1SG2895
ATOM 2895 CG PHE 371 91. .805 31, .616 24. .903 1, .00 40. .04 1SG2896
ATOM 2896 CDl PHE 371 91. .708 31, .241 26, .223 1 .00 40 .04 1SG2897
ATOM 2897 CD2 PHE 371 90. .651 31, .796 24. .175 1, .00 40, .04 1SG2898
ATOM 2898 CE1 PHE 371 90. .479 31. .062 26. .811 1, .00 40, .04 1SG2899
ATOM 2899 CE2 PHE 371 89. .418 31 .617 24. .759 1 .00 40 .04 1SG2900
ATOM 2900 CZ PHE 371 89. .331 31. .250 26, .080 1, .00 40, .04 1SG2901
ATOM 2901 C PHE 371 95, .114 33. .272 24, .324 1 .00 40 .04 1SG2902
ATOM 2902 O PHE 371 95. .321 33. .953 23. .320 1, .00 40, .04 1SG2903
ATOM 2903 N PRO 372 96. .066 32. .679 24. .985 1 .00 41 .44 1SG2904
ATOM 2904 CA PRO 372 97, .433 32 .818 24, .568 1 .00 41 .44 1SG2905
ATOM 2905 CD PRO 372 95, .952 32. .489 26, .423 1 .00 41 .44 1SG2906
ATOM 2906 CB PRO 372 98, .276 32 .307 25, .734 1 .00 41 .44 1SG2907
ATOM 2907 CG PRO 372 97. .389 32, .572 26, .964 1, .00 41, .44 1SG2908
ATOM 2908 C PRO 372 97, .696 32, .119 23, .273 1 .00 41 .44 1SG2909
ATOM 2909 O PRO 372 97. .116 31. .060 23. .033 1, .00 41. .44 1SG2910
ATOM 2910 N LEU 373 98. .580 32. .693 22, .433 1, .00 44, .42 1SG2911
ATOM 2911 CA LEU 373 98 .873 32 .109 21, .158 1, .00 44 .42 1SG2912
ATOM 2912 CB LEU 373 99. .022 33, .165 20, .047 1, .00 44. .42 1SG2913
ATOM 2913 CG LEU 373 98 .970 32 .588 18, .622 1, .00 44. .42 1SG2914
ATOM 2914 CD2 LEU 373 99, .429 33. .619 17, .578 1, .00 44, .42 1SG2915
ATOM 2915 CDl LEU 373 97, .568 32. .024 18, .325 1, .00 44, .42 1SG2916
ATOM 2916 C LEU 373 100 .177 31 .387 21, .322 1, .00 44 .42 1SG2917
ATOM 2917 O LEU 373 100, .959 31. .705 22. .217 1, .00 44, .42 1SG2918
ATOM 2918 N SER 374 100, .444 30 .376 20. .471 1, .00 46, .35 1SG2919
ATOM 2919 CA SER 374 101. .640 29, .607 20. .650 1. .00 46, .35 1SG2920
ATOM 2920 CB SER 374 101. .549 28, .234 19, .964 1, .00 46, .35 1SG2921
ATOM 2921 OG SER 374 102, .750 27 .505 20, .160 1 .00 46 .35 1SG2922
ATOM 2922 C SER 374 102. .797 30, .330 20, .042 1, .00 46, .35 1SG2923
ATOM 2923 O SER 374 103, .250 29 .994 18, .949 1, .00 46 .35 1SG2924
ATOM 2924 N ASN 375 103, .352 31, .323 20. .764 1, .00 47, .17 1SG2925
ATOM 2925 CA ASN 375 104, .496 31, .967 20. .197 1, .00 47, .17 1SG2926
ATOM 2926 CB ASN 375 104, .282 33 .428 19. .793 1, .00 47, .17 1SG2927
ATOM 2927 CG ASN 375 105, .370 33, .711 18. .772 1, .00 47, .17 1SG2928
ATOM 2928 ODl ASN 375 106, .553 33 .775 19, .097 1, .00 47, .17 1SG2929
ATOM 2929 ND2 ASN 375 104 , .960 33, .866 17. .484 1. .00 47, .17 1SG2930
ATOM 2930 C ASN 375 105, .603 31, .897 21. .198 1. .00 47, .17 1SG2931
ATOM 2931 O ASN 375 105, .396 31 .949 22. .409 1. .00 47, .17 1SG2932
ATOM 2932 N PRO 376 106. .787 31, .756 20. .684 1. .00 47. .98 1SG2933
ATOM 2933 CA PRO 376 107, .955 31, .681 21. .517 1. .00 47, .98 1SG2934
ATOM 2934 CD PRO 376 106. .970 31. .006 19. .454 1. .00 47. .98 1SG2935
ATOM 2935 CB PRO 376 109, .069 31. .086 20. .652 1. .00 47. .98 1SG2936
ATOM 2936 CG PRO 376 108, .487 31. .053 19. .227 1, .00 47. .98 1SG2937
ATOM 2937 C PRO 376 108. .259 33, .024 22. .088 1. .00 47. .98 1SG2938
ATOM 2938 O PRO 376 107, .628 33, .997 21. .686 1. .00 47. .98 1SG2939
ATOM 2939 N HIS 377 109. .201 33. .086 23. .047 1. .00 46. .64 1SG2940
ATOM 2940 CA HIS 377 109. .548 34. .304 23. ,719 1. .00 46. .64 1SG2941
ATOM 2941 NDl HIS 377 Ill, .814 36. .243 25. .327 1. .00 46. .64 1SG2942 ATOM 2942 CG HIS 377 110..815 35,.353 25..655 1..00 46,.64 1SG2943
ATOM 2943 CB HIS 377 110. .524 34, .095 24, .891 1. .00 46, .64 1SG2944
ATOM 2944 NE2 HIS 377 110. .803 37, .061 27, .131 1. .00 46, .64 1SG2945
ATOM 2945 CD2 HIS 377 110. .208 35, .868 26, .759 1. .00 46, .64 1SG2946
ATOM 2946 CE1 HIS 377 Ill, .762 37, .244 26, .242 1, .00 46, .64 1SG2947
ATOM 2947 C HIS 377 110, .182 35, .259 22, .755 1. .00 46, .64 1SG2948
ATOM 2948 O HIS 377 110. .642 34, .872 21, .683 1, .00 46, .64 1SG2949
ATOM 2949 N LYS 378 110, .177 36, .557 23, .132 1. .00 46, .42 1SG2950
ATOM 2950 CA LYS 378 110, .765 37 .654 22 .407 1, .00 46, .42 1SG2951
ATOM 2951 CB LYS 378 112, .312 37, .628 22 .377 1. .00 46, .42 1SG2952
ATOM 2952 CG LYS 378 112, .957 36, .329 21, .881 1. .00 46 .42 1SG2953
ATOM 2953 CD LYS 378 112, .762 36, .044 20, .391 1, .00 46, .42 1SG2954
ATOM 2954 CE LYS 378 113, .446 34, .759 19, .916 1, .00 46, .42 1SG2955
ATOM 2955 NZ LYS 378 113, .206 34 .564 18, .469 1, .00 46 .42 1SG2956
ATOM 2956 C LYS 378 110. .225 37 .764 21 .016 1. .00 46 .42 1SG2957
ATOM 2957 O LYS 378 110 .954 38 .079 20 .076 1. .00 46 .42 1SG2958
ATOM 2958 N PHE 379 108 .908 37 .546 20 .862 1. .00 43 .66 1SG2959
ATOM 2959 CA PHE 379 108 .266 37 .625 19 .581 1. .00 43 .66 1SG2960
ATOM 2960 CB PHE 379 107 .730 36 .245 19, .154 1. .00 43 .66 1SG2961
ATOM 2961 CG PHE 379 106 .774 36 .343 18 .010 1. .00 43 .66 1SG2962
ATOM 2962 CDl PHE 379 105 .437 36 .598 18 .225 1. .00 43 .66 1SG2963
ATOM 2963 CD2 PHE 379 107 .200 36 .166 16 .718 1. .00 43 .66 1SG2964
ATOM 2964 CE1 PHE 379 104, .554 36 .687 17 .182 1. .00 43 .66 1SG2965
ATOM 2965 CE2 PHE 379 106 .314 36 .252 15 .670 1, .00 43 .66 1SG2966
ATOM 2966 CZ PHE 379 104, .988 36 .514 15 .894 1, .00 43 .66 1SG2967
ATOM 2967 C PHE 379 107 .061 38 .497 19 .736 1. .00 43 .66 1SG2968
ATOM 2968 O PHE 379 106 .431 38 .519 20 .792 1. .00 43 .66 1SG2969
ATOM 2969 N LEU 380 106 .702 39 .223 18 .658 1. .00 39 .10 1SG2970
ATOM 2970 CA LEU 380 105 .506 40 .017 18 .638 1. .00 39 .10 1SG2971
ATOM 2971 CB LEU 380 105 .766 41, .528 18 .775 1, .00 39 .10 1SG2972
ATOM 2972 CG LEU 380 104 .480 42 .376 18 .754 1. .00 39 .10 1SG2973
ATOM 2973 CD2 LEU 380 104 .804 43 .875 18 .643 1. .00 39 .10 1SG2974
ATOM 2974 CDl LEU 380 103 .573 42 .049 19 .950 1. .00 39 .10 1SG2975
ATOM 2975 C LEU 380 104, .878 39 .794 17 .295 1. .00 39 .10 1SG2976
ATOM 2976 O LEU 380 105 .584 39 .648 16 .299 1. .00 39 .10 1SG2977
ATOM 2977 N PHE 381 103, .528 39 .753 17 .234 1. .00 36 .06 1SG2978
ATOM 2978 CA PHE 381 102 .833 39 .545 15 .987 1. .00 36 .06 1SG2979
ATOM 2979 CB PHE 381 101, .523 38 .733 16 .104 1. .00 36, .06 1SG2980
ATOM 2980 CG PHE 381 101, .768 37 .320 16 .495 1. .00 36, .06 1SG2981
ATOM 2981 CDl PHE 381 102, .065 36 .370 15, .545 1. .00 36, .06 1SG2982
ATOM 2982 CD2 PHE 381 101, .685 36. .940 17 .815 1. .00 36, .06 1SG2983
ATOM 2983 CE1 PHE 381 102, .288 35, .063 15, .908 1, .00 36, .06 1SG2984
ATOM 2984 CE2 PHE 381 101, .906 35, .634 18 .183 1, .00 36, .06 1SG2985
ATOM 2985 CZ PHE 381 102, .210 34 .693 17, .229 1. .00 36, .06 1SG2986
ATOM 2986 C PHE 381 102, .326 40, .880 15. .537 1. .00 36. .06 1SG2987
ATOM 2987 O PHE 381 101, .771 41. .636 16, .333 1. .00 36, .06 1SG2988
ATOM 2988 N VAL 382 102, .479 41, .197 14, .234 1. .00 30, .78 1SG2989
ATOM 2989 CA VAL 382 102, .006 42, .456 13, .734 1. .00 30. .78 1SG2990
ATOM 2990 CB VAL 382 103, .126 43, .451 13, .577 1. .00 30. .78 1SG2991
ATOM 2991 CGI VAL 382 102, .580 44, .784 13, .036 1. .00 30. .78 1SG2992
ATOM 2992 CG2 VAL 382 103. .846 43, .574 14, .930 1. .00 30. .78 1SG2993
ATOM 2993 C VAL 382 101. .414 42. .197 12, .376 1. .00 30. .78 1SG2994
ATOM 2994 O VAL 382 101. .653 41, .143 11, .789 1. .00 30, .78 1SG2995
ATOM 2995 N ASN 383 100. .612 43, .155 11, .856 1. .00 28. .57 1SG2996
ATOM 2996 CA ASN 383 100. .017 43, .078 10, .547 1. .00 28. .57 1SG2997
ATOM 2997 CB ASN 383 101. .014 43, .332 9. .403 1. .00 28. .57 1SG2998
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All references cited within the body of the instant specification are hereby incorporated by reference in their entirety.

Claims

WHAT IS CLAIMED IS:
1. A method for identifying a composition having bactericidal/permeability increasing factor- like (BPIL) biological activity, the method comprising the steps of:
(a) providing a BPILX molecular model comprising atomic coordinates defining a three-dimensional shape representative of at least a portion of BPIL;
(b) identifying a candidate analog having a three-dimensional shape corresponding to the three-dimensional shape representative of at least a portion of BPIL; and (c) producing the candidate analog identified in step (b).
2. The method of claim 1 , further comprising the step of determining whether the compound produced in step (c) has BPIL-like biological activity.
3. The method of claim 1, wherein the molecular model provided in step (a) is representative of at least a portion of a binding pocket region of BPIL.
4. The method of claim 1, wherein the analog comprises a plurality of charged moieties spaced about the solvent accessible surface thereof and disposed in a spaced-apart relation corresponding to charged moieties spaced about a portion of the solvent accessible surface of BPIL.
5. The method of claim 1, wherein steps (a) and (b) are performed by means of an electronic processor.
6. The method of claim 5, wherein step (a) comprises storing a representation of at least a portion of the atomic coordinates of BPIL in a computer memory.
7. A computer system comprising:
(a) a memory comprising atomic coordinates defining at least a portion of BPIL; and (b) a processor in electrical communication with the memory; wherein the processor generates a BPILX molecular model having a three-dimensional shape representative of at least a portion of BPIL.
8. The system of claim 7, wherein the processor further comprises a processor which generates the molecular model having a solvent accessible surface representative of at least a portion of BPIL.
9. The system of claim 7, wherein said coordinates are stored on a computer readable diskette.
10. The system of claim 7, wherein the molecular model is representative of at least a portion of BPIL binding pocket region.
11. The system of claim 7, wherein the processor further identifies a small molecule having a three-dimensional shape and a solvent accessible surface corresponding to at least a portion of the three-dimensional shape and the solvent accessible surface of BPIL.
12. The system of claim 7, wherein the processor further identifies at least one candidate amino acid defined by the coordinates, which upon modification enhances water solubility or stability of BPIL.
13. A computer comprising a memory containing a three-dimensional representation of BPIL or a portion of BPIL that includes the binding pocket region of BPIL.
14. The computer of claim 13, comprising a machine readable data storage medium, a data storage material coded with machine readable data, the data including the three-dimensional representation.
15. A machine readable data storage medium containing machine readable data, the data including a three-dimensional representation of BPIL or of a portion of BPIL that includes the BPIL binding pocket region.
16. The machine readable data storage medium of claim 15, wherein the three-dimensional representation is substantially defined by structural coordinates selected from the group consisting of: (a) the atomic coordinates of the amino acids of SEQ ID NO: 2 as set forth in Table 49
(b) the atomic coordinates of the amino acids of SEQ ID NO: 4 as set forth in Table 50
(c) the atomic coordinates of the amino acids of SEQ ID NO: 6 as set forth in Table 51
(d) the atomic coordinates of the amino acids of SEQ ID NO: 8 as set forth in Table 52
(e) the atomic coordinates of the amino acids of SEQ ID NO: 27 as set forth in Table 53 (f) the atomic coordinates of the amino acids of SEQ ID NO: 29 as set forth in Table 54
(g) the atomic coordinates of the amino acids of SEQ ID NO: 32 as set forth in Table 56
(h) the atomic coordinates of the amino acids of SEQ ID NO: 35 as set forth in Table 57
(i) the atomic coordinates of the amino acids of SEQ ID NO: 39 as set forth in Table 55
(j) the atomic coordinates of the amino acids of SEQ ID NO: 41 as set forth in Table 59 and
(k) the atomic coordinates of the amino acids of SEQ ID NO: 45 as set forth in Table 58.
17. A BPIL NH2 terminal binding pocket amino acid sequence, the amino acid sequence comprising two or more binding pocket residues substantially defined by structural coordinates selected from the group consisting of:
(a) the atomic coordinates of the amino acid sequences of SEQ ID NO:2 which are underlined in the Query sequence as set forth in Table 9, wherein the atomic coordinates of said underlined amino acids are set forth in Table 49;
(b) the atomic coordinates of the amino acid sequences of SEQ ID NO:4 which are underlined in the Query sequence as set forth in Table 10, wherein the atomic coordinates of said underlined amino acids are set forth in Table 50;
(c) the atomic coordinates of the amino acid sequences of SEQ ID NO:6 which are underlined in the Query sequence as set forth in Table 28, wherein the atomic coordinates of said underlined amino acids are set forth in Table 51 ; (d) the atomic coordinates of the amino acid sequences of SEQ ID NO:8 which are underlined in the Query sequence as set forth in Table 30, wherein the atomic coordinates of said underlined amino acids are set forth in Table 52;
(e) the atomic coordinates of the amino acid sequences of SEQ ID NO:27 which are underlined in the Query sequence as set forth in Table 32, wherein the atomic coordinates of said underlined amino acids are set forth in Table 53;
(f) the atomic coordinates of the amino acid sequences of SEQ ID NO:29 which are underlined in the Query sequence as set forth in Table 34, wherein the atomic coordinates of said underlined amino acids are set forth in Table 54; (g) the atomic coordinates of the amino acid sequences of SEQ ID NO:35 which are underlined in the Query sequence as set forth in Table 61, wherein the atomic coordinates of said underlined amino acids are set forth in Table 57;
(h) the atomic coordinates of the amino acid sequences of SEQ ID NO:39 which are underlined in the Query sequence as set forth in Table 36, wherein the atomic coordinates of said underlined amino acids are set forth in Table 55;
(i) the atomic coordinates of the amino acid sequences of SEQ ID NO:41 which are underlined in the Query sequence as set forth in Table 38, wherein the atomic coordinates of said underlined amino acids are set forth in Table 59; and
(j) the atomic coordinates of the amino acid sequences of SEQ ID NO:45 which are underlined in the Query sequence as set forth in Table 47, wherein the atomic coordinates of said underlined amino acids are set forth in Table 58.
18. The BPIL NH2 terminal binding pocket amino acid sequence of claim 17 that is a variant, mutant, analog, homolog, or derivative of the underlined amino acids of SEQ ID NO:2, 4, 6, 8, 27, 29, 32, 35, 39, 41, and 45.
19. A BPIL COOH terminal binding pocket amino acid sequence, the amino acid sequence comprising two or more binding pocket residues substantially defined by structural coordinates selected from the group consisting of: (a) the atomic coordinates of the amino acid sequences of SEQ ID NO:2 which are underlined in the Query sequence as set forth in Table 11, wherein the atomic coordinates of said underlined amino acids are set forth in Table 49;
(b) the atomic coordinates of the amino acid sequences of SEQ ID NO:4 which are underlined in the Query sequence as set forth in Table 12, wherein the atomic coordinates of said underlined amino acids are set forth in Table 50;
(c) the atomic coordinates of the amino acid sequences of SEQ ID NO:6 which are underlined in the Query sequence as set forth in Table 29, wherein the atomic coordinates of said underlined amino acids are set forth in Table 51 ; (d) the atomic coordinates of the amino acid sequences of SEQ ID NO: 8 which are underlined in the Query sequence as set forth in Table 31 , wherein the atomic coordinates of said underlined amino acids are set forth in Table 52;
(e) the atomic coordinates of the amino acid sequences of SEQ ID NO:27 which are underlined in the Query sequence as set forth in Table 33, wherein the atomic coordinates of said underlined amino acids are set forth in Table 53;
(f) the atomic coordinates of the amino acid sequences of SEQ ID NO:29 which are underlined in the Query sequence as set forth in Table 35, wherein the atomic coordinates of said underlined amino acids are set forth in Table 54;
(g) the atomic coordinates of the amino acid sequences of SEQ ID NO:35 which are underlined in the Query sequence as set forth in Table 62, wherein the atomic coordinates of said underlined amino acids are set forth in Table 57;
(h) the atomic coordinates of the amino acid sequences of SEQ ID NO:39 which are underlined in the Query sequence as set forth in Table 37, wherein the atomic coordinates of said underlined amino acids are set forth in Table 55; (i) the atomic coordinates of the amino acid sequences of SEQ ID NO:41 which are underlined in the Query sequence as set forth in Table 39, wherein the atomic coordinates of said underlined amino acids are set forth in Table 59; and
(j) the atomic coordinates of the amino acid sequences of SEQ ID NO:45 which are underlined in the Query sequence as set forth in Table 48, wherein the atomic coordinates of said underlined amino acids are set forth in Table 58.
20. The BPIL NH2 terminal binding pocket amino acid sequence of claim 19 that is a variant, mutant, analog, homolog, or derivative of the underlined amino acids of SEQ ID NO:2, 4, 6, 8, 27, 29, 32, 35, 39, 41, and 45.
21. A method for identifying a potential modulator of BPIL biological activity, the method comprising the following steps:
(1) designing or selecting a potential modulator of BPIL biological activity by utilizing a three- dimensional structure of a BPIL NH2 binding pocket amino acid sequence, the amino acid sequence comprising two or more receptor binding pocketresidues substantially defined by the structural coordinates selected from the group consisting of:
(a) the atomic coordinates of the amino acid sequences of SEQ ID NO:2 which are underlined in the Query sequence as set forth in Table 9, wherein the atomic coordinates of said underlined amino acids are set forth in Table 49;
(b) the atomic coordinates of the amino acid sequences of SEQ ID NO:4 which are underlined in the Query sequence as set forth in Table 10, wherein the atomic coordinates of said underlined amino acids are set forth in Table 50;
(c) the atomic coordinates of the amino acid sequences of SEQ ID NO:6 which are underlined in the Query sequence as set forth in Table 28, wherein the atomic coordinates of said underlined amino acids are set forth in Table 51 ; (d) the atomic coordinates of the amino acid sequences of SEQ ID NO: 8 which are underlined in the Query sequence as set forth in Table 30, wherein the atomic coordinates of said underlined amino acids are set forth in Table 52;
(e) the atomic coordinates of the amino acid sequences of SEQ ID NO:27 which are underlined in the Query sequence as set forth in Table 32, wherein the atomic coordinates of said underlined amino acids are set forth in Table 53;
(f) the atomic coordinates of the amino acid sequences of SEQ ID NO:29 which are underlined in the Query sequence as set forth in Table 34, wherein the atomic coordinates of said underlined amino acids are set forth in Table 54;
(g) the atomic coordinates of the amino acid sequences of SEQ ID NO:35 which are underlined in the Query sequence as set forth in Table 61 , wherein the atomic coordinates of said underlined amino acids are set forth in Table 57; (h) the atomic coordinates of the amino acid sequences of SEQ ID NO:39 which are underlined in the Query sequence as set forth in Table 35, wherein the atomic coordinates of said underlined amino acids are set forth in Table 55;
(i) the atomic coordinates of the amino acid sequences of SEQ ID NO:41 which are underlined in the Query sequence as set forth in Table 38, wherein the atomic coordinates of said underlined amino acids are set forth in Table 59; and
(j) the atomic coordinates of the amino acid sequences of SEQ ID NO:45 which are underlined in the Query sequence as set forth in Table 47, wherein the atomic coordinates of said underlined amino acids are set forth in Table 58; and (2) contacting the potential modulator with BPIL in the presence of a protein which binds to the BPIL superfamily to test the ability of the potential modulator to modulate the interaction between BPIL and the protein which binds to BPIL.
22. The method of claim 21, wherein the BPIL NH2 terminal binding pocket amino acid sequence is a variant, mutant, analog, homolog, or derivative of the underlined amino acids of SEQ ID NO:2, 4, 6, 8, 27, 29, 32, 35, 39, 41, and 45.
23. The method of claim 22, wherein the potential modulator causes the BPIL activity to increase.
24. The method of claim 21 wherein in step (1) the potential modulator is selected by screening modulators using a computer for interaction with the three-dimensional structure of BPIL binding pockets.
25. A method for identifying a potential modulator of BPIL biological activity, the method comprising the following steps:
(1) designing or selecting a potential modulator of BPIL biological activity by utilizing a three-dimensional structure of a BPIL COOH binding pocket amino acid sequence, the amino acid sequence comprising two or more binding pocketresidues substantially defined by the structural coordinates selected from the group consisting of: (a) the atomic coordinates of the amino acid sequences of SEQ ID NO:2 which are underlined in the Query sequence as set forth in Table 11, wherein the atomic coordinates of said underlined amino acids are set forth in Table 49;
(b) the atomic coordinates of the amino acid sequences of SEQ ID NO:4 which are underlined in the Query sequence as set forth in Table 12, wherein the atomic coordinates of said underlined amino acids are set forth in Table 50;
(c) the atomic coordinates of the amino acid sequences of SEQ ID NO:6 which are underlined in the Query sequence as set forth in Table 29, wherein the atomic coordinates of said underlined amino acids are set forth in Table 51 ; (d) the atomic coordinates of the amino acid sequences of SEQ ID NO: 8 which are underlined in the Query sequence as set forth in Table 31 , wherein the atomic coordinates of said underlined amino acids are set forth in Table 52;
(e) the atomic coordinates of the amino acid sequences of SEQ ID NO:27 which are underlined in the Query sequence as set forth in Table 33, wherein the atomic coordinates of said underlined amino acids are set forth in Table 53;
(f) the atomic coordinates of the amino acid sequences of SEQ ID NO:29 which are underlined in the Query sequence as set forth in Table 35, wherein the atomic coordinates of said underlined amino acids are set forth in Table 54;
(g) the atomic coordinates of the amino acid sequences of SEQ ID NO:35 which are underlined in the Query sequence as set forth in Table 62, wherein the atomic coordinates of said underlined amino acids are set forth in Table 57;
(h) the atomic coordinates of the amino acid sequences of SEQ ID NO:39 which are underlined in the Query sequence as set forth in Table 37, wherein the atomic coordinates of said underlined amino acids are set forth in Table 55; (i) the atomic coordinates of the amino acid sequences of SEQ ID NO:41 which are underlined in the Query sequence as set forth in Table 39, wherein the atomic coordinates of said underlined amino acids are set forth in Table 59; and
(j) the atomic coordinates of the amino acid sequences of SEQ ID NO:45 which are underlined in the Query sequence as set forth in Table 48, wherein the atomic coordinates of said underlined amino acids are set forth in Table 58; and (2) contacting the potential modulator with BPIL in the presence of a protein which binds to the BPIL superfamily to test the ability of the potential modulator to modulate the interaction between BPIL and the protein which binds to BPIL.
26. The method of claim 25, wherein the BPIL COOH terminal binding pocket amino acid sequence is a variant, mutant, analog, homolog, or derivative of the underlined amino acids of SEQ ID NO:2, 4, 6, 8, 27, 29, 32, 35, 39, 41, and 45.
27. The method of claim 26, wherein the potential modulator causes the BPIL activity to increase.
28. The method of claim 25 wherein in step (1) the potential modulator is selected by screening modulators using a computer for interaction with the three-dimensional structure of BPIL binding pockets.
29. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of: a) a mature form of the amino acid sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45; b) a variant of a mature form of the amino acid sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45, wherein any amino acid in the mature form is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence of the mature form are so changed; c) the amino acid sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45; d) a variant of the amino acid sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32,
35, 39, 41, and 45 wherein any amino acid specified in the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence are so changed; and e) a fragment of any of a) through d).
30. The polypeptide of claim 29 that is a naturally occurring allelic variant of the sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, AND 41.
31. 31. The polypeptide of claim 30, wherein the variant is the translation of a single nucleotide polymorphism. 5
32. The polypeptide of claim 29 that is a variant polypeptide described therein, wherein any amino acid specified in the chosen sequence is changed to provide a conservative substitution.
33. The polypeptide of claim 29, further comprising an NH2 terminal barrel domain, a central β 10 sheet domain, and a COOH-terminal barrel domain.
34. The polypeptide of claim 29, further comprising a binding pocket domain.
35. The polypeptide of claim 29, further comprising a cysteine-cysteine disulfide bond within 15 the NH2 terminal barrel domain.
36. An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of: a) a mature form of the amino acid sequence given SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 20 32, 35, 39, 41, and 45; b) a variant of a mature form of the amino acid sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45 wherein any amino acid in the mature form of the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence of the mature form are so changed;
25 c) the amino acid sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45; d) a variant of the amino acid sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45, in which any amino acid specified in the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the
30 sequence are so changed; e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising the amino acid sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45 or any variant of said polypeptide wherein any amino acid of the chosen sequence is changed to a different amino acid, provided that no more than 10% of the amino acid residues in the sequence are so changed; and f) the complement of any of said nucleic acid molecules.
37. The nucleic acid molecule of claim 36, wherein the nucleic acid molecule comprises the nucleotide sequence of a naturally occurring allelic nucleic acid variant.
38. The nucleic acid molecule of claim 36 that encodes a variant polypeptide, wherein the variant polypeptide has the polypeptide sequence of a naturally occurring polypeptide variant.
39. The nucleic acid molecule of claim 36, wherein the nucleic acid molecule comprises a single nucleotide polymorphism encoding said variant polypeptide.
40. The nucleic acid molecule of claim 36, wherein said nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of a) the nucleotide sequence given by SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, and 44; b) a nucleotide sequence wherein one or more nucleotides in the nucleotide sequence given by SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, and 44 is changed from that given by the chosen sequence to a different nucleotide provided that no more than 15% of the nucleotides are so changed; c) a nucleic acid fragment of the sequence given by SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, and 44; and d) a nucleic acid fragment wherein one or more nucleotides in the nucleotide sequence given by SEQ ID NO: 1, 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, and 44 is changed from that given by the chosen sequence to a different nucleotide provided that no more than 15% of the nucleotides are so changed.
41. The nucleic acid molecule of claim 36, wherein said nucleic acid molecule hybridizes under stringent conditions to the nucleotide sequence given by SEQ ID NO: 1 , 3, 5, 7, 9, 26, 28, 33, 36, 38, 40, and 44 or a complement of said nucleotide sequence.
42. The nucleic acid molecule of claim 36, wherein the nucleic acid molecule comprises a nucleotide sequence in which any nucleotide specified in the coding sequence of the chosen nucleotide sequence is changed from that given by the chosen sequence to a different nucleotide provided that no more than 15% of the nucleotides in the chosen coding sequence are so changed, an isolated second polynucleotide that is a complement of the first polynucleotide, or a fragment of any of them.
43. A vector comprising the nucleic acid molecule of claim 42.
44. The vector of claim 43, further comprising a promoter operably linked to said nucleic acid molecule.
45. A host cell genetically engineered to express the polypeptide of claim 29.
46. An antibody that binds immunospecifically to the polypeptide of claim 29.
47. The antibody of claim 46, wherein said antibody is a monoclonal antibody.
48. The antibody of claim 46, wherein the antibody is a humanized antibody.
49. A method for determining the presence or amount of the polypeptide of claim 29 in a sample, the method comprising: (a) introducing said sample to an antibody that binds to the polypeptide; and
(b) determining the presence or amount of antibody bound to said polypeptide, thereby determining the presence or amount of polypeptide in said sample.
50. A method for determining the presence or amount of the nucleic acid molecule of claim 36 in a sample, the method comprising:
(a) introducing said sample to a probe that binds to said nucleic acid molecule; and (b) determining the presence or amount of said probe bound to said nucleic acid molecule, thereby determining the presence or amount of the nucleic acid molecule in said sample.
51. A method of identifying an agent that binds to the polypeptide of claim 29, the method comprising:
(a) introducing said polypeptide to said agent; and
(b) determining whether said agent binds to said polypeptide.
52. A method for identifying a potential therapeutic agent for use in treatment of a pathology, wherein the pathology is related to aberrant expression or aberrant physiological interactions of the polypeptide of claim 29, the method comprising:
(a) providing a cell expressing the polypeptide of claim 29 and having a property or function ascribable to the polypeptide; (b) contacting the cell with a composition comprising a candidate substance; and
(c) determining whether the substance alters the property or function ascribable to the polypeptide; whereby, if an alteration observed in the presence of the substance is not observed when the cell is contacted with a composition devoid of the substance, the substance is identified as a potential therapeutic agent.
53. A method for modulating the activity of the polypeptide of claim 29, the method comprising introducing a cell sample expressing the polypeptide of said claim with a compound that binds to said polypeptide in an amount sufficient to modulate the activity of the polypeptide.
54. A method of treating or preventing a pathology associated with the polypeptide of claim 29, said method comprising administering the BPILX polypeptide to a subject in which such treatment or prevention is desired in an amount sufficient to treat or prevent said pathology in said subject.
55. The method of claim 54, wherein said subject is a human.
56. A method of treating or preventing a pathology associated with the polypeptide of claim 29, said method comprising administering to a subject in which such treatment or prevention is desired a BPIL nucleic acid in an amount sufficient to treat or prevent said pathology in said subject.
57. The method of claim 56, wherein said subject is a human.
58. A method of treating or preventing a pathology associated with the polypeptide of claim 29, said method comprising administering to a subject in which such treatment or prevention is desired a BPIL antibody in an amount sufficient to treat or prevent said pathology in said subject.
59. The method of claim 58, wherein the subject is a human.
60. A pharmaceutical composition comprising the polypeptide of claim 29 and a pharmaceutically acceptable carrier.
61. A pharmaceutical composition comprising the nucleic acid molecule of claim 36 and a pharmaceutically acceptable carrier.
62. A pharmaceutical composition comprising the antibody of claim 46 and a pharmaceutically acceptable carrier.
63. The use of a therapeutic in the manufacture of a medicament for treating a syndrome associated with a human disease, the disease selected from a pathology associated with the polypeptide of claim 29, wherein said therapeutic is the polypeptide of claim 29.
64. The use of a therapeutic in the manufacture of a medicament for treating a syndrome associated with a human disease, the disease selected from a pathology associated with the polypeptide of claim 29, wherein said therapeutic is a BPIL nucleic acid.
65. The use of a therapeutic in the manufacture of a medicament for treating a syndrome associated with a human disease, the disease selected from a pathology associated with the polypeptide of claim 29, wherein said therapeutic is a BPIL antibody.
66. A method for screening for a modulator of activity or of latency or predisposition to a pathology associated with the polypeptide of claim 29, said method comprising: a) administering a test compound to a test animal at increased risk for a pathology associated with the polypeptide of claim 29, wherein said test animal recombinantly expresses the polypeptide of claim 29; b) measuring the activity of said polypeptide in said test animal after administering the compound of step (a); and c) comparing the activity of said protein in said test animal with the activity of said polypeptide in a control animal not administered said polypeptide, wherein a change in the activity of said polypeptide in said test animal relative to said control animal indicates the test compound is a modulator of latency of, or predisposition to, a pathology associated with the polypeptide of claim 29.
67. The method of claim 66, wherein said test animal is a recombinant test animal that expresses a test protein transgene or expresses said transgene under the control of a promoter at an increased level relative to a wild-type test animal, and wherein said promoter is not the native gene promoter of said transgene.
68. A method for determining the presence of or predisposition to a disease associated with altered levels of the polypeptide of claim 29 in a first mammalian subject, the method comprising: a) measuring the level of expression of the polypeptide in a sample from the first mammalian subject; and b) comparing the amount of said polypeptide in the sample of step (a) to the amount of the polypeptide present in a control sample from a second mammalian subject known not to have, or not to be predisposed to, said disease, wherein an alteration in the expression level of the polypeptide in the first subject as compared to the control sample indicates the presence of or predisposition to said disease.
69. A method for determining the presence of or predisposition to a disease associated with altered levels of the nucleic acid molecule of claim 36 in a first mammalian subject, the method comprising: a) measuring the amount of the nucleic acid in a sample from the first mammalian subject; and b) comparing the amount of said nucleic acid in the sample of step (a) to the amount of the nucleic acid present in a control sample from a second mammalian subject known not to have or not be predisposed to, the disease; wherein an alteration in the level of the nucleic acid in the first subject as compared to the control sample indicates the presence of or predisposition to the disease.
70. A method of treating a pathological state in a mammal, the method comprising administering to the mammal a polypeptide in an amount that is sufficient to alleviate the pathological state, wherein the polypeptide is a polypeptide having an amino acid sequence at least 95% identical to a polypeptide comprising the amino acid sequence given by SEQ ID NO: 2, 4, 6, 8, 10, 27, 29, 32, 35, 39, 41, and 45 or a biologically active fragment thereof.
71. A method of treating a pathological state in a mammal, the method comprising administering to the mammal the antibody of claim 46 in an amount sufficient to alleviate the pathological state.
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