WO2001014420A3 - Novel members of the plexin family and uses thereof - Google Patents

Novel members of the plexin family and uses thereof Download PDF

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Publication number
WO2001014420A3
WO2001014420A3 PCT/US2000/023365 US0023365W WO0114420A3 WO 2001014420 A3 WO2001014420 A3 WO 2001014420A3 US 0023365 W US0023365 W US 0023365W WO 0114420 A3 WO0114420 A3 WO 0114420A3
Authority
WO
WIPO (PCT)
Prior art keywords
plexin
methods
diagnosis
novel
disclosed
Prior art date
Application number
PCT/US2000/023365
Other languages
French (fr)
Other versions
WO2001014420A2 (en
Inventor
Stefania Artigiani
Paolo M Comoglio
Corey S Goodman
Marc Tesier-Lavigne
Luca Tamagnone
Original Assignee
Univ Torino
Univ California
Stefania Artigiani
Paolo M Comoglio
Corey S Goodman
Tesier Lavigne Marc
Luca Tamagnone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Torino, Univ California, Stefania Artigiani, Paolo M Comoglio, Corey S Goodman, Tesier Lavigne Marc, Luca Tamagnone filed Critical Univ Torino
Priority to AU70738/00A priority Critical patent/AU7073800A/en
Publication of WO2001014420A2 publication Critical patent/WO2001014420A2/en
Publication of WO2001014420A3 publication Critical patent/WO2001014420A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides methods and compositions related to novel plexins. The polypeptides may be produced recombinantly from transformed host cells and from the disclosed plexin encoding nucleic acids or purified from human cells. The invention provides isolated plexin hybridization probes and primers capable of specifically hybridizing with the disclosed plexin genes, plexin-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in biopharmaceutical industry. The invention also provides novel plexin neuropilin multimeric receptor complexes for semaphorins and methods of use thereof, including but not limited to, the treatment and diagnosis of neurological disease and neuroregeneration, immune modulation, and viral and oncological diseases.
PCT/US2000/023365 1999-08-25 2000-08-25 Novel members of the plexin family and uses thereof WO2001014420A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU70738/00A AU7073800A (en) 1999-08-25 2000-08-25 Novel plexins and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15057699P 1999-08-25 1999-08-25
US60/150,576 1999-08-25

Publications (2)

Publication Number Publication Date
WO2001014420A2 WO2001014420A2 (en) 2001-03-01
WO2001014420A3 true WO2001014420A3 (en) 2002-05-10

Family

ID=22535146

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/023365 WO2001014420A2 (en) 1999-08-25 2000-08-25 Novel members of the plexin family and uses thereof

Country Status (2)

Country Link
AU (1) AU7073800A (en)
WO (1) WO2001014420A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402660B2 (en) 2000-08-02 2008-07-22 The Johns Hopkins University Endothelial cell expression patterns
WO2003035100A1 (en) * 2001-09-26 2003-05-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Neuropilin as a novel therapeutic target for modulation of immune reponses
US20070010433A1 (en) * 2002-07-11 2007-01-11 Sema Aps Use of compounds capable of inhibiting the proteolytic processing of semaphorins for prevention, treatment, diagnosis and prognosis of an invasive disease
ES2297953B1 (en) * 2003-06-30 2009-10-21 Progenika Biopharma, S.A. IN VITRO METHODS FOR THE DETECTION OF A CARCINOMA, DETERMINATION OF ITS STADIUM OR SEVERITY AND FOR THE DETERMINATION OF ITS DEVELOPMENT.
WO2005056791A1 (en) * 2003-10-30 2005-06-23 Kazusa Dna Research Institute Foundation Novel plexin polypeptide, dna encoding the same and use thereof
WO2005061704A1 (en) * 2003-12-24 2005-07-07 Takeda Pharmaceutical Company Limited Preventive/remedy for cancer
ES2632360T3 (en) 2005-07-21 2017-09-12 Modiquest B.V. Plexin D1 as a target for the diagnosis and therapy of tumors
US8871205B2 (en) * 2009-11-25 2014-10-28 The University Of North Carolina At Chapel Hill Methods and compositions for the treatment of immune disorders
EP2385121A1 (en) 2010-05-06 2011-11-09 Netris Pharma Antagonists of Sema3E/PlexinD1 interaction as anti-cancer agents
DE102010042359A1 (en) * 2010-10-12 2012-04-12 Protagen Ag Marker sequences for multiple sclerosis and their use
EP2487242A1 (en) * 2011-02-09 2012-08-15 Ruprecht-Karls-Universität Heidelberg B-type plexin antagonists and uses thereof
WO2012114339A1 (en) 2011-02-23 2012-08-30 Rappaport Family Institute For Research In The Medical Sciences High affinity molecules capable of binding a type a plexin receptor and uses of same
CN107337733A (en) * 2011-03-28 2017-11-10 哈佛大学校长及研究员协会 The conditioning agent of the activity of neuropile protein B 2
WO2015037009A1 (en) 2013-09-16 2015-03-19 Plexicure Ltd. Isolated proteins capable of binding plexin-a4 and methods of producing and using same
ES2969187T3 (en) 2015-06-29 2024-05-16 Univ British Columbia Treatments, methods and uses of B1SP fusion protein
EP3976650A1 (en) 2019-05-28 2022-04-06 Vib Vzw Cancer treatment by targeting plexins in the immune compartment
EP3976067A1 (en) 2019-05-28 2022-04-06 Vib Vzw Cd8+ t-cells lacking plexins and their application in cancer treatment
WO2022063957A1 (en) 2020-09-24 2022-03-31 Vib Vzw Biomarker for anti-tumor therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004263A1 (en) * 1997-07-17 1999-01-28 The John Hopkins University School Of Medicine Semaphorin receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004263A1 (en) * 1997-07-17 1999-01-28 The John Hopkins University School Of Medicine Semaphorin receptor

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
COMEAU, M. ET AL.: "A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR", IMMUNITY, vol. 8, April 1998 (1998-04-01), pages 473 - 482, XP000945259 *
DATABASE SWALL:O15031; ACCESSION-NO: O15031, 1 January 1998 (1998-01-01) *
EMBL DATABASE EM_HUM:AB014520; ACCESSION-NO.:AB014520, 15 July 1998 (1998-07-15), XP002173834 *
EMBL DATABASE EM_OV:XLPLEX; ACCESSION-NO:D38175, 25 August 1995 (1995-08-25), XP002173837 *
EMBL DATABASE EMHUM4:HS5211110; ACCESSION-NO: U52111, 9 May 1996 (1996-05-09), XP002173835 *
EMBL DATABASE EMHUM4:HSAB2313; ACCESSION-NO: AB002313, 1 July 1997 (1997-07-01), XP002157964 *
EMBL DATABASE EMHUM6:HSOCTPROT; ACCESSION-NO: X87831, 6 February 1996 (1996-02-06), XP002173836 *
ISHIKAWA, K.-I. ET AL.: "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro", DNA RESEARCH, vol. 5, 30 June 1998 (1998-06-30), pages 169 - 176, XP002121149 *
KAMEYAMA, T. ET AL.: "Identification of a cell surface protein plexin (the B2) in mouse, and its expression in developing nervous systems", NEUROSCIENCE RESEARCH SUPPLEMENT, vol. 18, 1993, pages S115, XP000945106 *
MAESTRINI, E. ET AL.: "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor", PROC.NATL.ACAD.SCI.USA, vol. 93, no. 2, 1996, pages 674 - 678, XP000941746 *
NAGASE, T. ET AL.: "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro", DNA RESEARCH, vol. 4, 1997, pages 141 - 150, XP002102085 *
NAKAMURA, F. ET AL.: "Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse", NEURON, vol. 21, November 1998 (1998-11-01), pages 1093 - 1100, XP002174004 *
OHTA, K. ET AL.: "Plexin: a novel neuronal cell surface molecule taht mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions", NEURON, vol. 14, 1995, pages 1189 - 1199, XP001013227 *
TAKAHASHI, T. ET AL.: "Plexin-Neuropilin-1 complexes form functional semaphorin-3A receptors", CELL, vol. 99, 1 October 1999 (1999-10-01), pages 59 - 69, XP000941701 *
TAMAGNONE, L. ET AL.: "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vetebrates", CELL, vol. 99, 1 October 1999 (1999-10-01), pages 71 - 80, XP000941702 *

Also Published As

Publication number Publication date
AU7073800A (en) 2001-03-19
WO2001014420A2 (en) 2001-03-01

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