WO2000032791A3 - Plan lecithin:cholesterol acyltransferases - Google Patents

Plan lecithin:cholesterol acyltransferases Download PDF

Info

Publication number
WO2000032791A3
WO2000032791A3 PCT/US1999/028586 US9928586W WO0032791A3 WO 2000032791 A3 WO2000032791 A3 WO 2000032791A3 US 9928586 W US9928586 W US 9928586W WO 0032791 A3 WO0032791 A3 WO 0032791A3
Authority
WO
WIPO (PCT)
Prior art keywords
lecithin
cholesterol
plan
cholesterol acyltransferases
acyltransferases
Prior art date
Application number
PCT/US1999/028586
Other languages
French (fr)
Other versions
WO2000032791A2 (en
Inventor
Rebecca E Cahoon
Anthony J Kinney
Hajime Sakai
Jennie Bih-Jien Shen
Karlene H Butler
James J Saylor
Original Assignee
Du Pont
Rebecca E Cahoon
Anthony J Kinney
Hajime Sakai
Shen Jennie Bih Jien
Karlene H Butler
James J Saylor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Rebecca E Cahoon, Anthony J Kinney, Hajime Sakai, Shen Jennie Bih Jien, Karlene H Butler, James J Saylor filed Critical Du Pont
Priority to AU21630/00A priority Critical patent/AU2163000A/en
Priority to US09/857,612 priority patent/US6940003B1/en
Publication of WO2000032791A2 publication Critical patent/WO2000032791A2/en
Publication of WO2000032791A3 publication Critical patent/WO2000032791A3/en
Priority to US11/073,512 priority patent/US7238863B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

This invention relates to an isolated nucleic acid fragment encoding a plant lecithin:cholesterol acyltransferases. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant lecithin:cholesterol acyltranferases, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the plant lecithin:cholesterol acyltransferases in a transformed host cell.
PCT/US1999/028586 1998-12-03 1999-12-02 Plan lecithin:cholesterol acyltransferases WO2000032791A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU21630/00A AU2163000A (en) 1998-12-03 1999-12-02 Plan lecithin:cholesterol acyltransferases
US09/857,612 US6940003B1 (en) 1998-12-03 1999-12-02 Plan lecithin: cholesterol acyltransferases
US11/073,512 US7238863B2 (en) 1998-12-03 2005-03-07 Plant lecithin:cholesterol acyltransferases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11078298P 1998-12-03 1998-12-03
US60/110,782 1998-12-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/073,512 Division US7238863B2 (en) 1998-12-03 2005-03-07 Plant lecithin:cholesterol acyltransferases

Publications (2)

Publication Number Publication Date
WO2000032791A2 WO2000032791A2 (en) 2000-06-08
WO2000032791A3 true WO2000032791A3 (en) 2000-09-14

Family

ID=22334901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028586 WO2000032791A2 (en) 1998-12-03 1999-12-02 Plan lecithin:cholesterol acyltransferases

Country Status (2)

Country Link
AU (1) AU2163000A (en)
WO (1) WO2000032791A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1360637A (en) 1999-04-12 2002-07-24 孟山都技术有限责任公司 Transgenic plants contg. altered levels of sterol compounds and tocopherols
AU7092900A (en) * 1999-08-30 2001-03-26 Monsanto Technology Llc Plant sterol acyltransferases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046767A1 (en) * 1997-04-11 1998-10-22 Takeda Chemical Industries, Ltd. Proteins having lecithin-cholesterol acyltransferase-like activity, their production and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046767A1 (en) * 1997-04-11 1998-10-22 Takeda Chemical Industries, Ltd. Proteins having lecithin-cholesterol acyltransferase-like activity, their production and use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
MURATA Y. ET AL.: "Cloning of rabbit LCAT cDNA: increase in LCAT mRNA abundance in the liver of cholesterol-fed rabbits", JOURNAL OF LIPID RESEARCH, vol. 37, 1996, pages 1616 - 1622, XP000913765 *
SASAKI T. ET AL.: "Rice EST AC D46513", EBI DATABASE, 9 March 1995 (1995-03-09), XP002139389 *
SHINN P. ET AL.: "Genomic Arabidopsis sequence AC AC004557; Q9ZW42", EBI DATABASE, 15 April 1998 (1998-04-15), XP002139390 *
WALBOT V. ET AL.: "Maize EST, AC AW147120", EBI DATABASE, 4 November 1999 (1999-11-04), XP002139392 *
WARDEN C. ET AL.: "Tissue-specific expression, developmental regulation, and chromosomal mapping of the lecithin:cholesterol acyltransferase gene", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 264, 1989, pages 21573 - 21581, XP002139391 *

Also Published As

Publication number Publication date
AU2163000A (en) 2000-06-19
WO2000032791A2 (en) 2000-06-08

Similar Documents

Publication Publication Date Title
WO2000032757A3 (en) Plant vitamin e biosynthetic enzymes
WO2000032756A3 (en) Sequenzes of a putative plant diacylglycerol acyltransferases
WO2001004147A3 (en) Plant inositol polyphosphate phosphatase homologs
WO1999055888A3 (en) Carotenoid biosynthesis enzymes
WO1999049050A3 (en) Limanthes oil genes
WO2000004166A3 (en) Plant cellulose synthases
WO2000014207A3 (en) Plant farnesyltransferases
WO1999049058A3 (en) Tryptophan biosynthetic enzymes
WO2000004154A3 (en) Genes encoding sulfate assimilation proteins
WO2000014239A3 (en) Thioredoxin h homologs
WO2000005353A3 (en) Chorismate synthase from plants
WO1999055883A3 (en) Triacylglycerol lipases
WO2000028036A3 (en) Disease resistance factors
WO1999053069A3 (en) Cell cycle regulatory proteins cdc2 and pitslre from plants
WO2000032792A3 (en) Plant 1-deoxy-d-xylulose 5-phosphate synthase
WO2000037652A3 (en) Flavonoid biosynthetic enzymes
WO1999028446A3 (en) Branched chain amino acid biosynthetic enzymes
WO2000060087A3 (en) Cyclin dependent kinase inhibitor genes from plants
WO1999048486A3 (en) Plant cell cyclin genes
WO2000006749A3 (en) Sulfur metabolism enzymes
WO2000032791A3 (en) Plan lecithin:cholesterol acyltransferases
WO1999057285A3 (en) Sucrose phosphate synthase
WO2001038502A3 (en) Oleoyl-acyl-carrier-protein thioesterases in plants
WO2000036121A3 (en) Plant protein phosphatases
WO2001049840A3 (en) Spf1-related transcription factors

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AU BA BB BG BR CA CN CR CU CZ DM EE GD GE HR HU ID IL IN IS JP KP KR LC LK LR LT LV MG MK MN MX NO NZ PL RO SG SI SK SL TR TT UA US UZ VN YU ZA

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AU BA BB BG BR CA CN CR CU CZ DM EE GD GE HR HU ID IL IN IS JP KP KR LC LK LR LT LV MG MK MN MX NO NZ PL RO SG SI SK SL TR TT UA US UZ VN YU ZA

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 09857612

Country of ref document: US

122 Ep: pct application non-entry in european phase