WO2000012690A3 - Laminin 5 for treatment of bone defects - Google Patents

Laminin 5 for treatment of bone defects Download PDF

Info

Publication number
WO2000012690A3
WO2000012690A3 PCT/US1999/019773 US9919773W WO0012690A3 WO 2000012690 A3 WO2000012690 A3 WO 2000012690A3 US 9919773 W US9919773 W US 9919773W WO 0012690 A3 WO0012690 A3 WO 0012690A3
Authority
WO
WIPO (PCT)
Prior art keywords
laminin
treatment
bone defects
bone
composition
Prior art date
Application number
PCT/US1999/019773
Other languages
French (fr)
Other versions
WO2000012690A9 (en
WO2000012690A2 (en
Inventor
Bryan J Tucker
Original Assignee
Desmos Inc
Bryan J Tucker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Desmos Inc, Bryan J Tucker filed Critical Desmos Inc
Priority to AU62409/99A priority Critical patent/AU6240999A/en
Priority to CA002348743A priority patent/CA2348743A1/en
Publication of WO2000012690A2 publication Critical patent/WO2000012690A2/en
Publication of WO2000012690A3 publication Critical patent/WO2000012690A3/en
Publication of WO2000012690A9 publication Critical patent/WO2000012690A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A method of treating a bone defect by administering to the bone defect a laminin 5 composition. Laminin 5 promotes bone growth and regeneration. The composition may also include one or more osteogenic and/or angiogenic factors. The growth and differentiation of bone marrow cells is also induced by laminin 5.
PCT/US1999/019773 1998-09-01 1999-08-27 Laminin 5 for treatment of bone defects WO2000012690A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU62409/99A AU6240999A (en) 1998-09-01 1999-08-27 Laminin 5 for treatment of bone defects
CA002348743A CA2348743A1 (en) 1998-09-01 1999-08-27 Laminin 5 for treatment of bone defects

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14538798A 1998-09-01 1998-09-01
US09/145,387 1998-09-01

Publications (3)

Publication Number Publication Date
WO2000012690A2 WO2000012690A2 (en) 2000-03-09
WO2000012690A3 true WO2000012690A3 (en) 2000-05-25
WO2000012690A9 WO2000012690A9 (en) 2001-01-04

Family

ID=22512881

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/019773 WO2000012690A2 (en) 1998-09-01 1999-08-27 Laminin 5 for treatment of bone defects

Country Status (3)

Country Link
AU (1) AU6240999A (en)
CA (1) CA2348743A1 (en)
WO (1) WO2000012690A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013302A1 (en) * 1989-04-28 1990-11-15 Brigham And Women's Hospital Novel materials and methods for guided tissue regeneration
WO1995006660A1 (en) * 1993-09-02 1995-03-09 Fred Hutchinson Cancer Research Center Epiligrin, an epithelial ligand for integrins
WO1997036621A1 (en) * 1996-03-29 1997-10-09 Desmos, Inc. Cellular attachment to laminin 5-coated trans-epithelial appliances
WO1998031798A1 (en) * 1997-01-16 1998-07-23 Human Genome Sciences, Inc. Human extracellular matrix-1

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013302A1 (en) * 1989-04-28 1990-11-15 Brigham And Women's Hospital Novel materials and methods for guided tissue regeneration
WO1995006660A1 (en) * 1993-09-02 1995-03-09 Fred Hutchinson Cancer Research Center Epiligrin, an epithelial ligand for integrins
WO1997036621A1 (en) * 1996-03-29 1997-10-09 Desmos, Inc. Cellular attachment to laminin 5-coated trans-epithelial appliances
WO1998031798A1 (en) * 1997-01-16 1998-07-23 Human Genome Sciences, Inc. Human extracellular matrix-1

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SWEENEY THOMAS M ET AL: "Repair of critical size rat calvarial defects using extracellular matrix protein gels.", JOURNAL OF NEUROSURGERY 1995, vol. 83, no. 4, 1995, pages 710 - 715, XP000891383, ISSN: 0022-3085 *
VUKICEVIC S ET AL: "Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: regulation by discrete domains of laminin", CELL, vol. 63, 1990, pages 437 - 445, XP002134083 *

Also Published As

Publication number Publication date
CA2348743A1 (en) 2000-03-09
WO2000012690A9 (en) 2001-01-04
AU6240999A (en) 2000-03-21
WO2000012690A2 (en) 2000-03-09

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