WO2000000224A3 - Verfahren zum transport molekularer substanz in vorgegebene bereiche eukaryontischer zellen - Google Patents

Verfahren zum transport molekularer substanz in vorgegebene bereiche eukaryontischer zellen Download PDF

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Publication number
WO2000000224A3
WO2000000224A3 PCT/DE1999/001805 DE9901805W WO0000224A3 WO 2000000224 A3 WO2000000224 A3 WO 2000000224A3 DE 9901805 W DE9901805 W DE 9901805W WO 0000224 A3 WO0000224 A3 WO 0000224A3
Authority
WO
WIPO (PCT)
Prior art keywords
transporting
molecular substance
predetermined areas
eucaryotic cells
nucleus
Prior art date
Application number
PCT/DE1999/001805
Other languages
English (en)
French (fr)
Other versions
WO2000000224A2 (de
Inventor
Wolf Bertling
Original Assignee
November Ag Molekulare Medizin
Wolf Bertling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by November Ag Molekulare Medizin, Wolf Bertling filed Critical November Ag Molekulare Medizin
Priority to EP99939916A priority Critical patent/EP1007107A2/de
Priority to CA002311119A priority patent/CA2311119A1/en
Publication of WO2000000224A2 publication Critical patent/WO2000000224A2/de
Publication of WO2000000224A3 publication Critical patent/WO2000000224A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
    • C12N2710/22022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Herstellung eines Vehikels zum Transport von molekularer Substanz in den Zellkern (ZK) einer eukaryontischen Zelle (Z), wobei mindestens ein virales Protein modifiziert wird, so daß es spezifisch für den Transport in den Zellkern (ZK) ist, und wobei das modifizierte virale Protein mit der molekularen Substanz gekoppelt oder assoziiert wird.
PCT/DE1999/001805 1998-06-29 1999-06-19 Verfahren zum transport molekularer substanz in vorgegebene bereiche eukaryontischer zellen WO2000000224A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99939916A EP1007107A2 (de) 1998-06-29 1999-06-19 Verfahren zum transport molekularer substanz in vorgegebene bereiche eukaryontischer zellen
CA002311119A CA2311119A1 (en) 1998-06-29 1999-06-19 Method for transporting a molecular substance in predetermined areas of eucaryotic cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19829005A DE19829005C2 (de) 1998-06-29 1998-06-29 Verfahren zum Transport molekularer Substanz in vorgegebene Bereiche eukaryontischer Zellen
DE19829005.5 1998-06-29

Publications (2)

Publication Number Publication Date
WO2000000224A2 WO2000000224A2 (de) 2000-01-06
WO2000000224A3 true WO2000000224A3 (de) 2000-04-13

Family

ID=7872407

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001805 WO2000000224A2 (de) 1998-06-29 1999-06-19 Verfahren zum transport molekularer substanz in vorgegebene bereiche eukaryontischer zellen

Country Status (4)

Country Link
EP (1) EP1007107A2 (de)
CA (1) CA2311119A1 (de)
DE (1) DE19829005C2 (de)
WO (1) WO2000000224A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19952957B4 (de) * 1999-11-03 2006-08-31 Acgt Progenomics Ag Modulare Transportsysteme für molekulare Substanzen und deren Herstellung und Verwendung

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259149A2 (de) * 1986-09-03 1988-03-09 The University of Saskatchewan Verwendung des Rotavirus-Nukleokapsid-VP6-Proteins in Impfstoffzusammensetzungen
US4950599A (en) * 1987-01-29 1990-08-21 Wolf Bertling Method for exchanging homologous DNA sequences in a cell using polyoma encapsulated DNA fragments
WO1992013568A1 (en) * 1991-02-04 1992-08-20 University Of Saskatchewan Vp6 encapsulated drug delivery
DE4335025A1 (de) * 1993-10-14 1995-04-20 Boehringer Ingelheim Int Endosomolytisch wirksame Partikel
WO1996040958A1 (en) * 1995-06-07 1996-12-19 Baylor College Of Medicine Nucleic acid transporters for delivery of nucleic acids into a cell
WO1997039134A1 (en) * 1996-04-17 1997-10-23 Scottish Crop Research Institute Virus-like particle
WO1997043431A1 (de) * 1996-05-10 1997-11-20 Wolf Bertling Vehikel zum transport von molekularer substanz
WO1999025324A1 (de) * 1997-11-13 1999-05-27 November Ag Gesellschaft Für Molekulare Medizin Verabreichung der wirkstoffe durch verwendung des aus polyoma-virus vp1 protein hergestellten kapsids

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259149A2 (de) * 1986-09-03 1988-03-09 The University of Saskatchewan Verwendung des Rotavirus-Nukleokapsid-VP6-Proteins in Impfstoffzusammensetzungen
US4950599A (en) * 1987-01-29 1990-08-21 Wolf Bertling Method for exchanging homologous DNA sequences in a cell using polyoma encapsulated DNA fragments
WO1992013568A1 (en) * 1991-02-04 1992-08-20 University Of Saskatchewan Vp6 encapsulated drug delivery
DE4335025A1 (de) * 1993-10-14 1995-04-20 Boehringer Ingelheim Int Endosomolytisch wirksame Partikel
WO1996040958A1 (en) * 1995-06-07 1996-12-19 Baylor College Of Medicine Nucleic acid transporters for delivery of nucleic acids into a cell
WO1997039134A1 (en) * 1996-04-17 1997-10-23 Scottish Crop Research Institute Virus-like particle
WO1997043431A1 (de) * 1996-05-10 1997-11-20 Wolf Bertling Vehikel zum transport von molekularer substanz
WO1999025324A1 (de) * 1997-11-13 1999-05-27 November Ag Gesellschaft Für Molekulare Medizin Verabreichung der wirkstoffe durch verwendung des aus polyoma-virus vp1 protein hergestellten kapsids

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOTECHNOL. APPL. BIOCHEM. (1999), 29(3), 269 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BRAUN, HELENE ET AL: "Oligonucleotide and plasmid DNA packaging into polyoma VP1 virus-like particles expressed in Escherichia coli. [Erratum to document cited in CA130:333439]", XP002128318, retrieved from STN Database accession no. 131:195095 *
FORSTOVA J ET AL: "POLYOMA VIRUS PSEUDOCAPSIDS AS EFFICIENT CARRIERS OF HETEROLOGOUS DNA INTO MAMMALIAN CELLS", HUMAN GENE THERAPY,XX,XX, vol. 6, no. 3, pages 297-306, XP000645479, ISSN: 1043-0342 *
KOMAL RAMANI ET AL.: "Site-specific gene delivery in vivo truogh engineered sendaiviral envelopes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 95, September 1998 (1998-09-01), WASHINGTON US, pages 11886 - 11890, XP000867253 *
REDMOND M J ET AL: "ROTAVIRUS PARTICLES FUNCTION AS IMMUNOLOGICAL CARRIERS FOR THE DELIVERY OF PEPTIDES FROM INFEXTIOUS AGENTS AND ENDOGENOUS PROTEINS", MOLECULAR IMMUNOLOGY,US,ELMSFORD, NY, vol. 28, no. 3, pages 269-278, XP002040017, ISSN: 0161-5890 *

Also Published As

Publication number Publication date
WO2000000224A2 (de) 2000-01-06
DE19829005A1 (de) 1999-12-30
CA2311119A1 (en) 2000-01-06
DE19829005C2 (de) 2000-08-31
EP1007107A2 (de) 2000-06-14

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