WO1997010023B1 - Equipment for transporting chemical and biological agents through tissue - Google Patents
Equipment for transporting chemical and biological agents through tissueInfo
- Publication number
- WO1997010023B1 WO1997010023B1 PCT/US1996/011289 US9611289W WO9710023B1 WO 1997010023 B1 WO1997010023 B1 WO 1997010023B1 US 9611289 W US9611289 W US 9611289W WO 9710023 B1 WO9710023 B1 WO 9710023B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tissue
- cap
- pump system
- pressure
- pump
- Prior art date
Links
- 210000001519 tissues Anatomy 0.000 title claims abstract 13
- 239000003124 biologic agent Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 3
- 239000012530 fluid Substances 0.000 claims abstract 2
- 239000012528 membrane Substances 0.000 claims abstract 2
- 230000001808 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 239000003365 glass fiber Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000005540 biological transmission Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
Abstract
A pump system for the delivery of liquid chemical and biological agents by diffusion from a prepackaged replaceable container into tissue by means of a combination of pressure waves including a base pressure. The pump system comprising a pump having a plurality of pistons driven by actuators, controlled by an electronic controller, at a certain repetition frequency and certain waveforms (up-ramp, peak and downramp) in combination with other signals of acoustic (sonic or ultrasonic) frequencies. The pump system also comprising a cap, in fluid communication with the pump via tubing and pressed against the tissue. The container being placed between the tissue and a membrane within the cap which transmits the pressure waveforms and acts as a piston pushing the agent out of the container and into the tissue. The cap also being capable of transmitting laser pulses to generate heat shock waves in the tissue aiding in the diffusion process in combination with the pressure variations.
Claims
AMENDED CLAIMS
[received by the International Bureau on 18 June 1997 ( 18 06 97), original claims 8 and 9 amended, remaining claims unchanged (2 pages)]
The cap (120) is formed out of material transparent for radiation in
the visible and infrared range with provisions for coupling to an optical
fiber for the transmission of laser pulses from a laser via the annular
cross-section of the cap to the tissue for generating pressure waves within
the tissue.
7. The pump system (10) of claim 1, wherein
the cap (120) is formed out of material transparent for radiation in the
visible and infrared range with a small-diameter coaxial cylinder in its
cavity, said cylinder having means, like a specifically placed mirror, for coupling laser pulses via an optical fiber via a cross-section of said
cylinder to the tissue for generating pressure waves within the tissue.
8. The pump system (10) of claim 1, wherein
the controller (210) comprises control circuitry including frequency
generators (220, 230 and 240) and controlled counters (260, 270) feeding into a digital-to-analog converter (280) for generating piecewise linear
waveforms, like upramp, peak, downramp and pause, at a certain
repetition frequency, said digital-to-analog converter (280) feeding into
the summing input of an operational amplifier (290), in conjunction with an acoustic frequency waveform from another oscillator (285), to generate
a resulting waveform for operating electromechanical actuators (50, 80)
driving pistons (40, 70) in the pump (20) for generating pressure wave¬
forms, including a base pressure with a minimum of zero, to be communi-
cated via tubing (110) to the cap (120) and via the membrane (126) to the
agent to be transported into the tissue (125), said pressure waveforms
being adaptable to specific kinds of tissue.
9. The pump system (10) of claim 8, wherein
the controller comprises circuitry controlling via a plurality of actuators
(50, 80) a plurality of pistons (40, 70) allowing one piston (30) to generate pressure waves of one acoustic frequency and another piston (80) to
generate pressure waves of another acoustic frequency and to maintain a
constant base pressure in the cap compensating for volume of agent
diffused into the tissue (125).
10. The pump system (10) of claim 8, wherein
the controller (210) and said plurality of pistons (40, 70) allow for a
suckback of said fluid medium via a valve (90) into said reservoir (100)
allowing the insertion of another container (130) and the start of another
pump process.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97995P | 1995-07-07 | 1995-07-07 | |
| US60/000,979 | 1995-07-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997010023A2 WO1997010023A2 (en) | 1997-03-20 |
| WO1997010023A3 WO1997010023A3 (en) | 1997-05-29 |
| WO1997010023B1 true WO1997010023B1 (en) | 1997-08-07 |
Family
ID=21693809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1996/011289 WO1997010023A2 (en) | 1995-07-07 | 1996-07-05 | Equipment for transporting chemical and biological agents through tissue |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1997010023A2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7804898A (en) * | 1997-06-19 | 1999-01-04 | Mile Creek Capital, Llc | Drug delivery system including a drug transport enhancement mechanism |
| AU2001286724A1 (en) * | 2000-08-24 | 2002-03-04 | Encapsulation Systems, Inc. | Ultrasonically enhanced substance delivery method |
| US8545440B2 (en) | 2007-12-21 | 2013-10-01 | Carticept Medical, Inc. | Injection system for delivering multiple fluids within the anatomy |
| US9044542B2 (en) | 2007-12-21 | 2015-06-02 | Carticept Medical, Inc. | Imaging-guided anesthesia injection systems and methods |
| WO2009086182A1 (en) | 2007-12-21 | 2009-07-09 | Carticept Medical, Inc. | Articular injection system |
| GB2544559A (en) * | 2015-11-23 | 2017-05-24 | Owen Mumford Ltd | Apparatus for medicament delivery |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63135179A (en) * | 1986-11-26 | 1988-06-07 | 立花 俊郎 | Subcataneous drug administration set |
| US4787888A (en) * | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
| US5386837A (en) * | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
| WO1994017771A2 (en) * | 1993-02-10 | 1994-08-18 | Siemens Aktiengesellschaft | Process and apparatus for analgesic therapy and/or for influencing the vegetative nervous system |
-
1996
- 1996-07-05 WO PCT/US1996/011289 patent/WO1997010023A2/en active Application Filing
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