WO1992006944A1 - Process for the preparation of naphthoquinones - Google Patents

Process for the preparation of naphthoquinones Download PDF

Info

Publication number
WO1992006944A1
WO1992006944A1 PCT/EP1991/001958 EP9101958W WO9206944A1 WO 1992006944 A1 WO1992006944 A1 WO 1992006944A1 EP 9101958 W EP9101958 W EP 9101958W WO 9206944 A1 WO9206944 A1 WO 9206944A1
Authority
WO
WIPO (PCT)
Prior art keywords
cerium
oxidation
salt
process according
quinone
Prior art date
Application number
PCT/EP1991/001958
Other languages
French (fr)
Inventor
Heinz-Manfred Becher
Original Assignee
Shell Internationale Research Maatschappij B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shell Internationale Research Maatschappij B.V. filed Critical Shell Internationale Research Maatschappij B.V.
Publication of WO1992006944A1 publication Critical patent/WO1992006944A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/04—Preparation of quinones by oxidation giving rise to quinoid structures of unsubstituted ring carbon atoms in six-membered aromatic rings

Definitions

  • the present invention relates to a process for the preparation of naphthoquinones, in particular naphtho-l,4-quinone, from the corresponding naphthalenes by oxidation using certain cerium salts. It is disclosed in DE 152 063 that naphthalene may be oxidized to naphtho-l,4-guinone using cerium (IV) sulphate, during which the cerium (IV) salt is reduced to cerium (III) sulphate. The cerium (III) sulphate so-formed may be converted back into cerium ( v ) sulphate by oxidation for economic and environmental reasons. Such an oxidation may be carried out using e.g.
  • the third process in which a solvent stable against oxidation and which is poorly water-miscible is added, is easy to operate and can be carried out in the optimal temperature range for oxidation (DE 18 04 727) . Thus, reasonable product yields can be obtained.
  • the solvent has to meet several requirements. Firstly, it has to be sufficiently stable under the oxidation conditions necessary for the naphthalene substrate. Secondly, the water miscibility of the solvent should be very low and the dissolving power for starting material and product sufficiently high. Thirdly, in oxidative regeneration of the cerium (III) salt, the solvent must not induce corrosion, for example as encountered with halogenated solvents. Finally, the solvent should possess a boiling point within the suitable temperature range, a low price and be safe with respect to the environment and toxicity.
  • Solvents disclosed in the relevant prior art suffer one or more disadvantages in that they have a low dissolving power for naphtho-l,4-quinone, for example aliphatic hydrocarbons and ethers, and/or increase the corrosion of the oxidation equipment, e.g. of the anode in an electrochemical process, for example chloro hydrocarbons, and/or are toxicologically unsafe, such as benzene.
  • Such solvents are not suitable for use as solvents in the oxidation of napthalene using cerium (IV) salts. Toluene does not possess the aforementioned disadvantages.
  • toluene is a very suitable solvent for the oxidation of naphthalenes to the respective naphtho-l,4-quinones by cerium (IV) salts.
  • the present invention provides a process for the preparation of a naphtho-l,4-quinone, which process comprises oxidising a napthalene by the action of an aqueous solution of a cerium (IV) salt and acid, characterised in that the oxidation is conducted in the presence of toluene as an organic solvent.
  • the napthalene starting material may, optionally, bear one or more substituents selected from those typical in the art.
  • Optional substituents may, for example, be alkyl groups. Alkyl moieties present as substituents preferably have from 1 to 10 carbon atoms, more preferably 1 to 6 carbon atoms.
  • the napthalene starting material is preferably not substituted. However, if a substituent is present, it is preferably in the 2-position. A most preferred substituent, if present, is methyl.
  • the acid to be used in the process of the present invention may be every suitable acid or mixture of acids, e.g. sulphuric acid, phosphoric
  • SUBSTITUTE SHEET acid and hydrochloric acid, or mixtures thereof.
  • sulphuric acid amongst others because its stability during electrochemical regeneration of cerium (III) .
  • concentration of sulphuric acid is between 5 and 20% wt, preferably between 10 and 20% wt, in view of the solubility of the cerium salts, its specific gravity with regard to the separation step and its electrolytic conductivity_
  • the cerium (IV) salt used in the process may be any suitable salt.
  • a preferred cerium (IV) salt is cerium (IV) sulphate.
  • the napthalene is dissolved in toluene and then thoroughly mixed with an aqueous solution of the cerium (IV) salt in dilute sulphuric acid.
  • the pH of the reaction mixture is preferably below 3, preferably below 1.
  • the concentration of the napthalene in toluene is suitably between 1 and 30% wt, especially between 10 and 15% wt.
  • the concentration of cerium salt is suitably between 0.01 and 1M, especially between 0.10 and 0.5M.
  • the selectivity of the cerium (IV) salt oxidation is reduced as the temperature at which the process is conducted increases. It is a particular advantage of the process of the present invention that it can be operated efficiently at relatively low temperatures.
  • the process is preferably operated at a temperature below about 75*C.
  • the reaction is carried out at a temperature in the range from 55"C to 65"C.
  • the aqueous cerium (III) salt solution obtained may, if desired, be subjected to electrochemical oxidation or oxidation using ozone, during which particular advantages of the process according to the invention may be realised.
  • the electrolysis serves to oxidise the cerium (III) salt formed during the process to the corresponding cerium (IV) salt, for further use in the process. This electrolysis stage is facilitated by the aforementioned advantages of using toluene as the solvent in the process.
  • Toluene meets the aforementioned requirements of a solvent for the process, in that it has sufficient chemical stability under the oxidation conditions, poor water-miscibility, high dissolving power for the starting material and product, no stimulation of corrosion, -low toxicity and hence a high level of environmental safety, a suitable boiling point and an economic price.
  • Naphthalene (11.5g, 0.090 mol) dissolved in toluene (120 ml) was thoroughly stirred at 50"C with the aforementioned solution (2.4 1), until the concentration of cerium ions determined by iodometric titration had dropped to 0.36 - 0.38 M (after about 50-60 in.).
  • the layers were then separated and the aqueous layer extracted with toluene (120 ml) .
  • the collected organic layers ere washed with water (120 ml) containing a small amount of hydrogen peroxide.
  • the wash water and the aqueous layer of the reaction mixture were collected and evaporated in vacuo at a maximum temperature of 50"C to the original volume (2.4 1).
  • the aqueous layer of the reaction mixture was electrolyzed on a Pb0_ anode.
  • the amperage was regulated such that only a small amount of oxygen was formed at the anode.
  • concentration of cerium (III) ions was about 0.04 mol/1, the electrolysis was stopped.
  • the electrolytically oxidized solution was stirred with toluene (100 ml) containing the material of the mother liquor of the first batch and additional naphthalene (11 g, 0.086 mol) . Work-up was carried out as described above for the batch.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)

Abstract

A process for the preparation of a naphtho-1,4-quinone, which process comprises oxidising a naphthalene by the action of an aqueous solution of a cerium (IV) salt and an acid, characterised in that the oxidation is conducted in the presence of toluene as an organic solvent. The cerium (IV) salt may be prepared by electrochemical oxidation of the corresponding cerium (III) salt formed during a preceding oxidation.

Description

PROCESS FOR THE PREPARATION OF NAPHTHOQUINONES
The present invention relates to a process for the preparation of naphthoquinones, in particular naphtho-l,4-quinone, from the corresponding naphthalenes by oxidation using certain cerium salts. It is disclosed in DE 152 063 that naphthalene may be oxidized to naphtho-l,4-guinone using cerium (IV) sulphate, during which the cerium (IV) salt is reduced to cerium (III) sulphate. The cerium (III) sulphate so-formed may be converted back into cerium ( v) sulphate by oxidation for economic and environmental reasons. Such an oxidation may be carried out using e.g. ozone, but electrolysis of the cerium (III) sulphate in dilute sulfuric acid is at present a particularly suitable process for this purpose. In order to carry out the oxidation process as efficient as possible, especially to achieve a sufficient current efficiency during an electrolysis process, organic components have to be removed prior to oxidation. prerequisite for a simple separation is the execution of the oxidation of the naphthalene substrate with the cerium (IV) sulphate dissolved in dilute acid, especially sulfuric acid, in a biphasic reaction mixture. The following processes for the preparation of naphtoquinones have been disclosed in the prior art:
1) oxidation of finely ground, solid napthalene without the addition of organic solvents and at, a temperature sufficiently low to avoid adhesion of the napthalene particles (DE 32 20 305) .
2) oxidation of molten napthalene without the addition of organic solvents at a temperature of from 80 to 100'C (DE 18 04 727).
3) oxidation of napthalene in a suitable solvent that is both stable against oxidation and poorly water-miscible. However, the processes disclosed in the prior art have a number of serious disadvantages. The first process is complicated because the starting material has to be ground to a particle size of approximately 0.1 mm, the process requires a special reactor in which reaction and filtration can alternately be carried out, the volume-time yield is low, and, additionally, the conversion of napthalene is low (<70%; I.M. Dalrymple and J.T. Millington, J. Appl. Electroche . 16, 885 (1986)) .
Compared to the first process, operation of the second process is easier. However, the conversion of the starting material is even lower. Further, this process has to be carried out in such a way that the formed quinone does not crystallize, otherwise, the organic layer is prevented from being mixed sufficiently with the oxidating solution. Moreover, the process requires a reaction temperature of more than 80*C, at which temperature the selectivity of cerium (IV) sulphate is significantly reduced, compared with operation at lower temperatures. This reduced selectivity results in a low conversion of
SUBSTITUTE SHEET naphthalene (<50%; DE 32 20 305) and in product mixtures which are difficult to purify.
The third process, in which a solvent stable against oxidation and which is poorly water-miscible is added, is easy to operate and can be carried out in the optimal temperature range for oxidation (DE 18 04 727) . Thus, reasonable product yields can be obtained. However, for successful and efficient operation of the process, -the solvent has to meet several requirements. Firstly, it has to be sufficiently stable under the oxidation conditions necessary for the naphthalene substrate. Secondly, the water miscibility of the solvent should be very low and the dissolving power for starting material and product sufficiently high. Thirdly, in oxidative regeneration of the cerium (III) salt, the solvent must not induce corrosion, for example as encountered with halogenated solvents. Finally, the solvent should possess a boiling point within the suitable temperature range, a low price and be safe with respect to the environment and toxicity.
Solvents disclosed in the relevant prior art suffer one or more disadvantages in that they have a low dissolving power for naphtho-l,4-quinone, for example aliphatic hydrocarbons and ethers, and/or increase the corrosion of the oxidation equipment, e.g. of the anode in an electrochemical process, for example chloro hydrocarbons, and/or are toxicologically unsafe, such as benzene. Such solvents are not suitable for use as solvents in the oxidation of napthalene using cerium (IV) salts. Toluene does not possess the aforementioned disadvantages. However, it has been generally accepted that toluene would not be stable under the oxidation conditions prevailing in the preparation of naptho-l,4-quinones by the aforementioned process. In particular, it has been disclosed in the prior art (DE 158 609; Tetrahedron Lett. 1966, 4493) that toluene is readily oxidized to benzaldehyde by cerium (IV) salts, and also by other mild oxidants (M.V. Bhatt and P.T. Perumal, Tetrahedron Lett. 1981, 2605; US 3,647,715; H. Kropf, E. Muller and H. Weickmann in Houben-Weyl, Methoden der organischen Chemie, 4th ed. vol. 4/la, Stuttgart 1981).
In complete contrast to the general teaching and understanding of the prior art, it has, most surprisingly, been found that toluene is a very suitable solvent for the oxidation of naphthalenes to the respective naphtho-l,4-quinones by cerium (IV) salts.
Accordingly, the present invention provides a process for the preparation of a naphtho-l,4-quinone, which process comprises oxidising a napthalene by the action of an aqueous solution of a cerium (IV) salt and acid, characterised in that the oxidation is conducted in the presence of toluene as an organic solvent.
The napthalene starting material may, optionally, bear one or more substituents selected from those typical in the art. Optional substituents may, for example, be alkyl groups. Alkyl moieties present as substituents preferably have from 1 to 10 carbon atoms, more preferably 1 to 6 carbon atoms. The napthalene starting material is preferably not substituted. However, if a substituent is present, it is preferably in the 2-position. A most preferred substituent, if present, is methyl.
The acid to be used in the process of the present invention may be every suitable acid or mixture of acids, e.g. sulphuric acid, phosphoric
SUBSTITUTE SHEET, acid and hydrochloric acid, or mixtures thereof. Especially preferred is sulphuric acid, amongst others because its stability during electrochemical regeneration of cerium (III) . The optimum concentration of sulphuric acid is between 5 and 20% wt, preferably between 10 and 20% wt, in view of the solubility of the cerium salts, its specific gravity with regard to the separation step and its electrolytic conductivity_
The cerium (IV) salt used in the process may be any suitable salt. A preferred cerium (IV) salt is cerium (IV) sulphate.
The napthalene is dissolved in toluene and then thoroughly mixed with an aqueous solution of the cerium (IV) salt in dilute sulphuric acid. The pH of the reaction mixture is preferably below 3, preferably below 1. The concentration of the napthalene in toluene is suitably between 1 and 30% wt, especially between 10 and 15% wt.
The concentration of cerium salt is suitably between 0.01 and 1M, especially between 0.10 and 0.5M.
As discussed above in relation to the prior art processes, the selectivity of the cerium (IV) salt oxidation is reduced as the temperature at which the process is conducted increases. It is a particular advantage of the process of the present invention that it can be operated efficiently at relatively low temperatures. Thus, the process is preferably operated at a temperature below about 75*C. Preferably, the reaction is carried out at a temperature in the range from 55"C to 65"C.
After completion of the reaction, the two phases of the reaction mixture are separated and the
SUBSTITUTE SHEET, naphtho-l,4-quinone product recovered by usual methods from the organic layer.
The aqueous cerium (III) salt solution obtained may, if desired, be subjected to electrochemical oxidation or oxidation using ozone, during which particular advantages of the process according to the invention may be realised. The electrolysis serves to oxidise the cerium (III) salt formed during the process to the corresponding cerium (IV) salt, for further use in the process. This electrolysis stage is facilitated by the aforementioned advantages of using toluene as the solvent in the process.
The process may be carried out either in batches or, advantageously, in a continuous flow operation. Toluene meets the aforementioned requirements of a solvent for the process, in that it has sufficient chemical stability under the oxidation conditions, poor water-miscibility, high dissolving power for the starting material and product, no stimulation of corrosion, -low toxicity and hence a high level of environmental safety, a suitable boiling point and an economic price.
The present invention will be further understood from the following illustrative examples.
EXAMPLES
Example 1
Preparation of naphtho-1, -quinone by oxidation of naphthalene using an aqueous cerium (III) and cerium (IV) sulphate solution acidified with sulphuric acid The solution used for the oxidation of naphthalene contained the following compounds: 0.60 mol/1 cerium (IV) sulphate (= 0.60 M Ce 4+) 0.10 mol/1 cerium (III) sulphate (= 0.20 M Ce 3+) 1.0 - 1.2 mol/1 sulphuric acid. Naphthalene (11.5g, 0.090 mol) dissolved in toluene (120 ml) was thoroughly stirred at 50"C with the aforementioned solution (2.4 1), until the concentration of cerium ions determined by iodometric titration had dropped to 0.36 - 0.38 M (after about 50-60 in.). The layers were then separated and the aqueous layer extracted with toluene (120 ml) . The collected organic layers ere washed with water (120 ml) containing a small amount of hydrogen peroxide. The wash water and the aqueous layer of the reaction mixture were collected and evaporated in vacuo at a maximum temperature of 50"C to the original volume (2.4 1).
The washed toluene solution was evaporated in vacuo at max. 60*C as far as possible. The residue was subjected to a steam distillation in vacuo- whereby toluene and unreacted naphthalene distilled with the water. Almost pure naphtho-l,4-quinone and water remained in the still. Toluene was added and the organic layer was evaporated .in vacuo after separation of the water. Analysis by thin layer chro atography (silica gel, acetone/heptane, 1:1) proved the product to be pure. Yield: 12.0 g (84% of theoretical referred to naphthalene; 82% of th. referred to Ce(IV) ions)
Mp.: 117-123'C (after sintering: lll'C)
Example 2:
Preparation of naphtho-l,4-quinone by oxidation of naphthalene using an aqueous cerium (III) and cerium (IV) solution acidified with sulphuric acid, followed by electrolytic regeneration of the cerium salt solution:
S BSTITUTE? SH^Γ: A solution of naphthalene (13.0 g, 0.10 mol) in toluene (100 ml) was thoroughly stirred with a solution (5 1) containing Ce(S0.)_ (0.122 mo1/1) and Ce2(S0.)3 (0.02 mol/1, electrolytically regenerated cerium sulphate solution) in aqueous sulphuric acid (20%) at 58-60'C for 40 in. Subsequently, the layers were separated and the aqueous layer extracted with toluene (100 ml) .
The collected organic layers were washed with water (50 ml) and then evaporated in vacuo at 60"C bath temperature until a small amount of product precipitated. The evaporation was stopped and the residue chilled in an ice bath, whereby the major part of the formed naphtho-l,4-quinone crystallized and the unreacted naphthalene remained completely dissolved. After 20-30 minutes of cooling, the precipitate was collected by vacuum filtration and dried in a circulating air drier. The mother liquor was used for the following batch.
The aqueous layer of the reaction mixture was electrolyzed on a Pb0_ anode. The amperage was regulated such that only a small amount of oxygen was formed at the anode. When the concentration of cerium (III) ions was about 0.04 mol/1, the electrolysis was stopped.
For the following batch, the electrolytically oxidized solution was stirred with toluene (100 ml) containing the material of the mother liquor of the first batch and additional naphthalene (11 g, 0.086 mol) . Work-up was carried out as described above for the batch.
Yield: 85% of th. referred to naphthalene
Purity: >99%.
SUB • ts <__. Example 3:
Preparation of 2-methyl naphtho-l,4-quinone by oxidation of 2-methyl naphthalene using a cerium (IV) sulphate solution acidified with sulphuric acid: A solution of 2-methyl naphthalene (1.42 g, 10 mmol) in toluene (30 ml) was thoroughly stirred with a solution of cerium (IV) sulphate (30 g, 75 mmol) and concentrated sulphuric acid (60 ml) in water (600 ml) at 70°C for 9 hours. Subsequently, the layers were separated, the organic layer twice washed with water and then evaporated in vacuo to dryness. The crystalline residue was recrystallized from ethanol.
Yield: 1.5 g (87% of th. calculated on the 2-methyl naphthalene)
Mp.: 101-103°C

Claims

1. A process for the preparation of a naphtho-1,4- quinone, which process comprises oxidising a naphthalene by the action of an aqueous solution of a cerium (IV) salt and an acid, characterised in that the oxidation is conducted in the presence of toluene as an organic solvent.
2. A process according to claim 1, characterised in that the oxidation is conducted at a temperature below 75-C.
3. process according to claim 2, characterised in that the oxidation is conducted at a temperature in the range of from 55"C to 65*C.
4. A process according to any preceding claim, characterised in that the cerium (IV) salt is cerium (IV) sulphate.
5. A process according to any preceding claim, characterised in that the cerium (IV) salt is prepared by oxidation of the corresponding cerium (III) salt produced during a preceding oxidation.
6. A process according to claim 5, characterised in that the oxidation process is an electrochemical process.
•≠-
BUBST.Yt"^ ^ϊ-- -
7. A process according to any of the proceeding claims, characterised in that the napho-l,4-quinone is napho-l,4-quinone.
8. A process according to any of the proceeding claims, characterised in that the acid is sulfuric acid.
9. A process according to claim 1, which is carried out substantially as hereinbefore described having reference to any one of Examples 1 to 3.
10. A naphtho-l,4-quinone whenever produced by a process according to any preceding claim.
SUBSTITUTE SHEET
PCT/EP1991/001958 1990-10-15 1991-10-11 Process for the preparation of naphthoquinones WO1992006944A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90119725 1990-10-15
EP90119725.1 1990-10-15

Publications (1)

Publication Number Publication Date
WO1992006944A1 true WO1992006944A1 (en) 1992-04-30

Family

ID=8204615

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/001958 WO1992006944A1 (en) 1990-10-15 1991-10-11 Process for the preparation of naphthoquinones

Country Status (1)

Country Link
WO (1) WO1992006944A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109265333A (en) * 2018-11-20 2019-01-25 四川省银河化学股份有限公司 A kind of preparation method of β-menadione

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3510498A (en) * 1965-06-21 1970-05-05 Great Lakes Carbon Corp Oxidation of fused ring hydrocarbons
US4632782A (en) * 1983-05-26 1986-12-30 Kawasaki Kasei Chemicals Limited Oxidizing an organic compound
JPH06152382A (en) * 1992-11-10 1994-05-31 Fujitsu Ltd Level conversion circuit

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3510498A (en) * 1965-06-21 1970-05-05 Great Lakes Carbon Corp Oxidation of fused ring hydrocarbons
US4632782A (en) * 1983-05-26 1986-12-30 Kawasaki Kasei Chemicals Limited Oxidizing an organic compound
JPH06152382A (en) * 1992-11-10 1994-05-31 Fujitsu Ltd Level conversion circuit

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 104, 1986, Columbus, Ohio, US; abstract no. 232913, TAKAHASHI, YOJIRO ET AL.: 'ELECTROCHEMICAL OXIDATION OF AROMATIC COMPOUNDS.' page 528 ;column 2 ; see abstract & JP,A,6 152 382 (NIPPON SHOKUBAI KAGAKU KOGYO CO.,LTD.) 15 March 1986 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109265333A (en) * 2018-11-20 2019-01-25 四川省银河化学股份有限公司 A kind of preparation method of β-menadione
CN109265333B (en) * 2018-11-20 2021-09-07 四川省银河化学股份有限公司 Preparation method of beta-menadione

Similar Documents

Publication Publication Date Title
FI80256C (en) Process for oxidation of an organic compound
US4394227A (en) Electrochemical process for the preparation of benzanthrones and planar, polycyclic aromatic oxygen-containing compounds
US2867569A (en) Electrolysis process
Green et al. The identification of linoleic and linolenic acids
US4794172A (en) Ceric oxidant
US3509031A (en) Electrochemical oxidation of phenol
US3592748A (en) Preparation of quinones
WO1992006944A1 (en) Process for the preparation of naphthoquinones
JPH0394085A (en) Production of 1-aminoanthraquinones
Torii et al. A facile access to α-phenylselenenyl carbonyl compounds by electrochemical oxidation
Saotome et al. The synthesis of α, ω-disubstituted higher alkanes from α, α, α, ω-tetrachloroalkanes
US4061548A (en) Electrolytic hydroquinone process
CN101955217B (en) Preparation method of menadione nicotinamide bisulfite
US4814495A (en) Method for the preparation of hydroxybenzoic acid
US3928432A (en) Process for preparation of 2-methoxy-3,6-dichloro-benzoic acid
CA1088556A (en) Continuous oxidation of tetrachlorocatechol to o- chloranil
US4387245A (en) Preparation of diacetoneketogulonic acid by oxidation of diacetonesorbose
US4612399A (en) Purification of 4-fluoro-4&#39;-hydroxybenzophenone
JPS6157818B2 (en)
JPH0564936B2 (en)
US3418224A (en) Preparation of sulfones by electrolytic oxidation
US2963410A (en) Electrolytic method of preparing ketoximes
EP0618312A1 (en) Process for obtaining n-acetyl homocysteine thiolactone from DL-homocystine by electrochemical methods
EP0337175B1 (en) Electrochemical synthesis of 2-aryl-hydroquinones
JPS5913597B2 (en) Improved method for oxidizing elemental phosphorus

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP NO US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE

NENP Non-entry into the national phase

Ref country code: CA