UA107476C2 - Фармацевтична субстанція на основі мітохондріально адресованих антиоксидантів - Google Patents

Фармацевтична субстанція на основі мітохондріально адресованих антиоксидантів

Info

Publication number
UA107476C2
UA107476C2 UAA201207236A UAA201207236A UA107476C2 UA 107476 C2 UA107476 C2 UA 107476C2 UA A201207236 A UAA201207236 A UA A201207236A UA A201207236 A UAA201207236 A UA A201207236A UA 107476 C2 UA107476 C2 UA 107476C2
Authority
UA
Ukraine
Prior art keywords
mitochondrially
basis
pharmaceutical substance
addressed compounds
addressed
Prior art date
Application number
UAA201207236A
Other languages
English (en)
Russian (ru)
Inventor
Maxim Vladimirovich Skulachev
Vladimir Petrovich Skulachev
Andrei Alexandrovich Zamyatin
Evgeny Stepanovich Efremov
Vadim Neronovich Tashlitsky
Lev Sergeevich Yaguzhinsky
Galina Anatolievna Korshunova
Natalya Vladimirovna Sumbatyan
Yury Nikolaevich Antonenko
Inna Isaakovna Severina
Boris Viktorovich Chernyak
Original Assignee
Ltd Liability Company Mitotekh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ltd Liability Company Mitotekh filed Critical Ltd Liability Company Mitotekh
Publication of UA107476C2 publication Critical patent/UA107476C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/02—Quinones with monocyclic quinoid structure
    • C07C50/04—Benzoquinones, i.e. C6H4O2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/12—Naphthoquinones, i.e. C10H6O2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G01N33/5079—Mitochondria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)

Abstract

,(І)
UAA201207236A 2009-11-13 2009-11-13 Фармацевтична субстанція на основі мітохондріально адресованих антиоксидантів UA107476C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2009/000621 WO2011059355A1 (ru) 2009-11-13 2009-11-13 Фармацевтические субстанции на основе митохондриально-адресованных антиоксидантов

Publications (1)

Publication Number Publication Date
UA107476C2 true UA107476C2 (uk) 2015-01-12

Family

ID=43991821

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201207236A UA107476C2 (uk) 2009-11-13 2009-11-13 Фармацевтична субстанція на основі мітохондріально адресованих антиоксидантів

Country Status (14)

Country Link
US (1) US9233903B2 (uk)
EP (1) EP2500336A1 (uk)
JP (1) JP2013510849A (uk)
KR (1) KR20120125980A (uk)
CN (1) CN102791670A (uk)
AU (1) AU2009355359B2 (uk)
BR (1) BR112012011197A2 (uk)
CA (2) CA2789846C (uk)
EA (1) EA023248B1 (uk)
IL (1) IL219533A (uk)
MX (1) MX2012005356A (uk)
UA (1) UA107476C2 (uk)
WO (1) WO2011059355A1 (uk)
ZA (1) ZA201203345B (uk)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9192676B2 (en) * 2011-06-03 2015-11-24 Mitotech Sa Oral formulations of mitochondrially-targeted antioxidants and their preparation and use
EP3030267A2 (en) 2013-04-11 2016-06-15 Mitotech SA Mitochondrially-targeted timoquinones and toluquinones
WO2019002936A2 (en) 2017-06-26 2019-01-03 Mitotech S.A. SET OF COMPOUNDS TARGETING MITOCHONDRIA
CN109232219A (zh) * 2018-11-11 2019-01-18 苏州怡彼得生物技术有限公司 一种线粒体靶向抗氧化剂skq1中间体2,3-二甲基-对苯醌的合成方法
CN109232216A (zh) * 2018-11-11 2019-01-18 苏州怡彼得生物技术有限公司 一种线粒体靶向抗氧化剂skq1二季膦盐衍生物的合成方法
CN109900652B (zh) * 2019-04-29 2021-06-04 北京普赞生物技术有限公司 一种食品中双乙酸钠的快速检测方法
KR102527406B1 (ko) 2021-01-15 2023-04-28 아주대학교산학협력단 미토콘드리아 기능 장애 관련 질환 예방 또는 치료용 조성물
KR102410556B1 (ko) 2020-01-16 2022-06-20 아주대학교산학협력단 미토콘드리아 타겟팅용 펩타이드
WO2022055811A1 (en) 2020-09-09 2022-03-17 Social Profit Network Methods and compositions for delivery of biotin to mitochondria
WO2023220365A1 (en) * 2022-05-13 2023-11-16 Virginia Tech Intellectual Properties, Inc. Mitochondrial antioxidant treatment for cask-linked neurodevelopmental disorders

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538974A (en) 1994-01-27 1996-07-23 Senju Pharamceutical Co., Ltd. Ophthalmic composition for lowering intraocular pressure
US6331532B1 (en) 1998-11-25 2001-12-18 University Of Otago Mitochondrially targeted antioxidants
WO1999026582A2 (en) 1997-11-25 1999-06-03 University Of Otago Mitochondrially targeted compounds
US20070270381A1 (en) 2000-05-25 2007-11-22 Antipodean Pharmaceuticals, Inc. Mitochondrially targeted antioxidants
US20080275005A1 (en) 1998-11-25 2008-11-06 Murphy Michael P Mitochondrially targeted antioxidants
US20020044913A1 (en) 2000-02-11 2002-04-18 Hamilton Nathan D. Cosmetics to support skin metabolism
ITRM20010755A1 (it) 2001-12-20 2003-06-20 Simonelli Giuseppe Uso del chinone q10 per il trattamento delle malattie oculari.
US6984636B2 (en) 2002-08-12 2006-01-10 Medical Research Council Mitochondrially targeted antioxidants
WO2005032544A1 (en) 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Treatment of mitochondrial diseases
CN1997403A (zh) 2004-07-13 2007-07-11 奥里迪斯生物医学研究及开发有限责任公司 靶向线粒体的抗氧化剂在治疗肝病和上皮癌中的用途
KR20070057218A (ko) 2004-08-30 2007-06-04 가부시키가이샤 가네카 미토콘드리아 활성화제
RU2318500C2 (ru) * 2005-10-18 2008-03-10 Общество С Ограниченной Ответственностью "Митотехнология" Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели
WO2008048134A1 (fr) 2006-10-20 2008-04-24 Limited Liability Company 'mitotechnology' Compositions pharmaceutiques pour la prévention et le traitement de pathologies oculaires
WO2008094062A1 (fr) * 2007-01-29 2008-08-07 Limited Liability Company 'mitotechnology' Compositions pharmaceutiques servant à la prévention et au traitement de maladies oncologiques
WO2009005386A1 (fr) 2007-06-29 2009-01-08 Limited Liability Company 'mitotechnology' Utilisation de compositions à adressage mitochondrial dans la prévention et le traitement de maldies cardio-vasculaires
JP5798481B2 (ja) 2008-06-25 2015-10-21 エジソン ファーマシューティカルズ， インコーポレイテッド 酸化ストレス疾患を治療するための２−ヘテロシクリルアミノアルキル−（ｐ−キノン）誘導体

Also Published As

Publication number Publication date
EP2500336A1 (en) 2012-09-19
CA2789846C (en) 2020-02-25
CA3068007C (en) 2022-08-23
AU2009355359A1 (en) 2012-06-07
EA201200604A1 (ru) 2012-09-28
ZA201203345B (en) 2013-01-30
US9233903B2 (en) 2016-01-12
BR112012011197A2 (pt) 2020-10-20
US20120259110A1 (en) 2012-10-11
MX2012005356A (es) 2013-01-29
JP2013510849A (ja) 2013-03-28
IL219533A (en) 2017-04-30
CN102791670A (zh) 2012-11-21
EA023248B1 (ru) 2016-05-31
KR20120125980A (ko) 2012-11-19
CA2789846A1 (en) 2011-05-19
IL219533A0 (en) 2012-06-28
AU2009355359B2 (en) 2016-11-10
CA3068007A1 (en) 2011-05-19
WO2011059355A1 (ru) 2011-05-19

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