TWI491420B - Degradable antibacterial biomedical multi-layer film - Google Patents

Description

Degradable antibacterial biomedical multilayer film

This invention relates to a plastic material, and more particularly to a biodegradable plastic material.

In daily life, people often cut their skin due to accidental touching of sharp objects. In order to protect the wound, an antibacterial bandage is applied to the wound to prevent the wound from expanding into the wound or daily activities, and the wound can be healed.

The aforementioned antibacterial bandages are generally made of a plastic material that is not easily decomposed, so that it is extremely burdensome to the environment when disposed of. If the incineration method is used to treat the bandage, the bandage after incineration will produce toxic gas and cause secondary damage to the environment.

In view of this, it is not necessary to provide a degradable antibacterial biomedical multilayer film to improve the defects of the conventional degradable antibacterial biomedical multilayer film.

Therefore, one aspect of the present invention is to provide a degradable antibacterial The multi-layer film, the degradable antibacterial biomedical multilayer film has a film layer and an adhesive layer, wherein the adhesive layer has an antibacterial compound and has a good antibacterial effect.

According to the above aspect of the invention, a degradable antibacterial biomedical multilayer film is proposed. In one embodiment, the degradable antimicrobial biofilm multilayer comprises a film layer and an adhesive layer, wherein the adhesive layer is disposed on the film layer.

The foregoing film layer is formed from a first biodegradable composition, wherein the first biodegradable composition comprises a first polylactic acid, a copolymer, a crystal promoter, and a plasticizer. The first polylactic acid has a weight average molecular weight of 80,000 to 300,000. The copolymer is obtained by copolymerizing an unsaturated polyester polymer or an unsaturated polyether polymer, an epoxy compound and an acrylic compound, and the copolymer has at least one first reactive organic group, wherein the first A reactive organic group can include, but is not limited to, an epoxy group, an acryl group, a carboxyl group, an alcohol group, an ether group, an amine group, a guanamine group, or any combination of the above organic groups.

The amount of the co-polymer used is from 0.5 part by weight to 20 parts by weight based on 100 parts by weight of the first polylactic acid, and from 0.1 part by weight to 5 parts by weight of the crystallizing agent, and the use of a plasticizer The amount is from 0.1 part by weight to 20 parts by weight.

The aforementioned adhesive layer is formed by the second biodegradable composition, wherein the second biodegradable composition comprises a second polylactic acid, a polymer mixture, a compatibilizer, an antibacterial compound, and an antioxidant. The above polymer mixture comprises a polyester polymer and a polyether polymer, and the polymer mixture has at least one second reactive organic group. This second reactive organic group may include, but is not limited to, a carboxyl group, an alcohol group, an ether group, an amine group, an amidino group or an upper group. Any combination of organic groups.

The use amount of the second polylactic acid is 100 parts by weight, the amount of the polymer mixture used is 0.1 parts by weight to 49 parts by weight, and the amount of the compatibilizing agent used is 0.1 parts by weight to 2 parts by weight, and the amount of the antibacterial compound is used. It is from 0.1 part by weight to 1 part by weight, and the antioxidant is used in an amount of from 0.1 part by weight to 1 part by weight.

According to an embodiment of the invention, the longitudinal degradation elongation of the above-mentioned degradable antibacterial biomedical multilayer film is not less than 200%, and the transverse elongation at break of the degradable antibacterial biomedical multilayer film is greater than 100%.

According to another embodiment of the present invention, the amount of the copolymer used is from 2 parts by weight to 12 parts by weight based on 100 parts by weight of the first polylactic acid, and the amount of the crystal promoter is from 0.5 parts by weight to 3 parts by weight. And the plasticizer is used in an amount of from 2 parts by weight to 15 parts by weight.

According to still another embodiment of the present invention, the amount of the polymer mixture used is 5 parts by weight to 25 parts by weight, and the amount of the compatibilizing agent is 0.2 parts by weight to 0.6 parts by weight, based on 100 parts by weight of the second polylactic acid. The antibacterial compound is used in an amount of from 0.3 part by weight to 0.8 part by weight, and the antioxidant is used in an amount of from 0.2 part by weight to 0.5 part by weight.

According to still another embodiment of the present invention, the degradable antibacterial biomedical multilayer film of the present invention further comprises a release film. The release film is disposed on the adhesive layer, and the adhesive layer is disposed between the release film and the film layer. The release film system is formed by a third biodegradable composition. The third biodegradable composition comprises a third polylactic acid, a plasticizer, a compatible compound, a nucleating agent, and a slip agent. The amount of the plasticizer used is 0.1 parts by weight based on 100 parts by weight of the third polylactic acid. To 25 parts by weight, the compatible compound is used in an amount of from 0.1 part by weight to 15 parts by weight, the nucleating agent is used in an amount of from 0.1 part by weight to 5 parts by weight, and the amount of the slip agent used is from 0.1 part by weight to 5 parts by weight.

According to still another embodiment of the present invention, the plasticizer is used in an amount of from 1 part by weight to 20 parts by weight, based on the third polylactic acid, and the amount of the compatibilizing compound is from 2 parts by weight to 12 parts by weight. The nucleating agent is used in an amount of from 0.3 part by weight to 3 parts by weight, and the amount of the slip agent used is from 0.3 part by weight to 3 parts by weight.

According to still another embodiment of the present invention, the heat-resistant temperature of the biodegradable biomedical multilayer film is not lower than 70 °C.

The degradable antibacterial biomedical multilayer film of the present invention is produced by a co-extrusion process, so that the degradable antibacterial biomedical multilayer film has better mechanical properties, and the biodegradable composition is used to fabricate the present invention. The multilayer film allows the degradable antibacterial biomedical multilayer film to be decomposed in a natural environment. Furthermore, the adhesive layer of the degradable antibacterial biomedical multilayer film is provided with an antibacterial compound, and has a good antibacterial effect.

The making and using of the embodiments of the invention are discussed in detail below. However, it will be appreciated that the embodiments provide many applicable inventive concepts that can be implemented in a wide variety of specific content. The specific embodiments discussed are illustrative only and are not intended to limit the scope of the invention.

The "heat resistant temperature" described in the present invention means the "heat distortion temperature" of the polymer material. When the polymer material is in a high temperature state, the polymer material melts and softens. If a pressure is applied to the polymer material at the same time, the appearance will change, and in severe cases, the polymer material will be permanently deformed or damaged. The heat-resistant temperature of the polymer material is generally measured by the D648 test method of the American Society for Testing and Materials (ASTM). The D648 test method was measured using a test piece having a size of 127 mm × 12.7 mm × 3.2 mm. First, 64kg / cm ² or 18.6kg / cm ² load is placed in the center of the test piece, and at 2 deg.] C / ppm heated condition, until the amount of deformation of a test piece of 0.25 mm. This temperature is the heat resistant temperature of the polymer material.

The degradable antibacterial biomedical multilayer film of the present invention comprises a film layer and an adhesive layer, wherein the adhesive layer is disposed on the film layer.

The film layer described above is formed of a first biodegradable composition, and the first biodegradable composition comprises a first polylactic acid, a copolymer, a crystal promoter, and a plasticizer. The first biodegradable composition has an average moisture content of no more than 200 ppm. If the average moisture content of the first biodegradable composition exceeds 200 ppm, the first polylactic acid contained therein will be cleaved, which is not advantageous for the subsequent co-extrusion process.

The first polylactic acid described above may have a weight average molecular weight of 80,000 to 300,000. In one embodiment, the first polylactic acid may have a weight average molecular weight of from 120,000 to 200,000. The first polylactic acid may comprise any combination of D-type polylactic acid, L-type polylactic acid, D, L-type polylactic acid or the above polylactic acid.

The above-mentioned copolymer is obtained by copolymerizing an unsaturated polyester polymer or an unsaturated polyether polymer, an epoxy compound and an acrylic compound, and the copolymer has at least one first reactive organic group. This first anti The organic group may include an epoxy group, an acryl group, a carboxyl group, an alcohol group, an ether group, an amine group, a guanamine group, a reactive organic group which can be reacted and mixed with polylactic acid, and can form hydrogen with polylactic acid. A reactive organic group of a bond, any other suitable reactive organic group, or any combination of the above reactive organic groups.

The above-mentioned copolymer having the aforementioned first reactive organic group may react with polylactic acid to form a branched bond to form a reaction blend, or may be bonded to the polylactic acid by a hydrogen bond, thereby improving the first bio-availability. The compatibility between the formulations in the film composition is broken down and the interaction force between the first polylactic acid and the copolymer is enhanced. The copolymer may be used in an amount of from 0.5 part by weight to 20 parts by weight based on 100 parts by weight of the first polylactic acid. In one embodiment, the copolymer may be used in an amount of from 2 parts by weight to 12 parts by weight. When the amount of the copolymer used is less than 0.5 part by weight, the effect of improving the compatibility of the copolymer is not good. If the amount of the copolymer used is more than 20 parts by weight, the composition of the first biodegradable film composition is difficult to process.

The aforementioned crystallizing agent may comprise an aromatic sulfonic acid metal salt compound, an aromatic metal phosphate metal salt compound, a fatty acid metal salt compound, an inorganic filler, other suitable crystallizing agents, or any mixture of the above materials. Specific examples of the foregoing inorganic filler, such as: nano clay, graphite, kaolin, mica, montmorillonite, cerium oxide, calcium carbonate, aluminum hydroxide, aluminum oxide, aluminum carbonate, calcium lactate, barium sulfate, glass fiber or Shell powder and so on.

The crystallizing agent can cause moderate crystallization of the polylactic acid in the composition to enhance the heat resistance of the biodegradable film. The amount of the crystallizing agent used is from 0.1 part by weight to 5 parts by weight based on 100 parts by weight of the first polylactic acid. In one embodiment, the amount of the crystal promoter is 0.5 parts by weight to 3 Parts by weight. If the amount of the crystallizing agent used is less than 0.1 parts by weight, a small amount of the crystallizing agent does not easily increase the crystallinity of the polylactic acid when the stretching is carried out. If the amount of the crystallizing agent used is more than 5 parts by weight, the biodegradable film produced has poor light transmittance and impact resistance, and the biodegradable film is degraded.

The above plasticizer may comprise a polyunsaturated polyester polymer, a polyamidoamine-based compound, other suitable plasticizers or any mixture of the above materials. The plasticizer of the present invention can improve the mechanical properties of the multilayer film, and can produce a multilayer film which is thinner and less susceptible to cracking. The plasticizer is used in an amount of from 0.1 part by weight to 20 parts by weight based on 100 parts by weight of the first polylactic acid. In one embodiment, the plasticizer is used in an amount of from 2 parts by weight to 15 parts by weight. When the amount of the plasticizer used is less than 0.1 part by weight, the produced multilayer film is liable to be broken. If the amount of the plasticizer used is more than 20 parts by weight, the thickness of the multilayer film produced is not uniform, and the effectiveness of the multilayer film is lowered.

The above adhesive layer is formed by the second biodegradable composition, and the second biodegradable composition comprises the second polylactic acid, the polymer mixture, the compatibilizing agent, the antibacterial compound and the antioxidant. The second biodegradable composition has an average moisture content of no more than 200 ppm. If the average moisture content of the second biodegradable composition exceeds 200 ppm, the second polylactic acid contained therein is cleaved.

The second polylactic acid may have a weight average molecular weight of 30,000 to 60,000, wherein the second polylactic acid has a lower molecular weight, so that the second biodegradable composition produced has a viscosity and can adhere to the surface of the material. Therefore, if the weight average molecular weight of the second polylactic acid is greater than 60000, the viscosity of the second biodegradable composition is poor, which affects the present invention. Degradable antibacterial biomedical multilayer film efficacy.

In one embodiment, the second polylactic acid may have a weight average molecular weight of from 40,000 to 50,000. The second polylactic acid may comprise any combination of D-type polylactic acid, L-type polylactic acid, D, L-type polylactic acid or the above polylactic acid.

The above polymer mixture may contain any mixture of a polyester polymer, a polyether polymer, other suitable polymer materials, or the above polymer materials. The foregoing polyester polymer may comprise polyhydroxybutyrate, polybutylene succinate, polycaprolactone, a copolymer of polyadipate and butylene terephthalate, and other suitable polyesters. Any combination of a polymer or the above polyester polymer. The polyether polymer described above may contain any mixture of polyoxyethylene ether, polyphenylene ether, other suitable polyether polymer or the above polyether polymer. The polymer mixture has at least one second reactive organic group. The second reactive organic group can comprise a carboxyl group, an alcohol group, an ether group, an amine group, a guanamine group, other suitable reactive organic groups, or any combination of the above reactive organic groups.

The aforementioned polymer mixture can adjust the adhesion and ductility of the adhesive layer, so that the adhesive layer can be applied to the extension processing. The polymer mixture is used in an amount of from 0.1 part by weight to 49 parts by weight based on 100 parts by weight of the second polylactic acid. In one embodiment, the polymer mixture is used in an amount of from 5 parts by weight to 25 parts by weight. If the amount of the polymer mixture used is less than 0.1 parts by weight, the amount of the polymer mixture used is too low, so that the adhesive layer is not suitable for the stretching process, and the adhesive layer is broken during the elongation processing. If the amount of the polymer mixture used is more than 49 parts by weight, the heat resistance of the formed adhesive layer is not good, so that the degradable antibacterial biomedical multilayer film produced is easily formed. Residual glue, which in turn reduces its effectiveness.

The above compatibilizer may comprise a peroxy compound, a compound having a non-saturated reactive functional group, other suitable compounds or any mixture of the above materials. The aforementioned compound having an unsaturated reactive functional group may contain an unsaturated carboxylic acid ester compound (for example, a methyl acrylate compound), an epoxy compound (for example, an epoxy soybean oil or an epoxy linseed oil), and a polyunsaturated polycondensation. An ester (for example: isocyanate) or a polyamidamine compound (for example, a stearylamine compound).

The aforementioned compatibilizing agent enables reactive compatibilization between the components, so that the second biodegradable composition forms a homogeneous phase, thereby improving the mechanical properties and heat resistance of the biodegradable film produced. The compatibilizer is used in an amount of from 0.1 part by weight to 1 part by weight based on 100 parts by weight of the second polylactic acid. In one embodiment, the compatibilizer is used in an amount of from 0.2 parts by weight to 0.6 parts by weight. If the amount of compatibilizer used is less than 0.1 parts by weight, too little compatibilizer does not allow reactive compatibilization between the components, and does not allow the second biodegradable thin film composition to form a homogeneous phase. If the amount of the compatibilizer used is more than 1 part by weight, too much compatibilizer may cause too much bonding between the components, so that the resulting degradable antibacterial biomedical multilayer film is not biodegradable.

The above antibacterial compound may comprise a natural plant essential oil compound, a metal ion compound, an organic compound containing a nitrogen ion, other suitable antibacterial compound or any mixture of the above compounds. The antibacterial compound contains an inorganic antibacterial agent and an organic antibacterial agent, and can form a synergistic effect to reduce the amount of the antibacterial compound used. The antibacterial compound is used in an amount of from 0.1 part by weight to 1 part by weight based on 100 parts by weight of the second polylactic acid. In an embodiment In the case where the second polylactic acid is used in an amount of 100 parts by weight, the antibacterial compound is used in an amount of from 0.3 part by weight to 0.8 part by weight. If the amount of the antibacterial compound used is more than 1 part by weight, the prepared antibacterial layer does not meet the safe addition ratio as stipulated by government regulations. When the amount of the antibacterial compound used is less than 0.1 part by weight, the synergistic effect produced by the antibacterial compound cannot be effectively sterilized, and the antibacterial effect of the antibacterial compound is lowered.

The above-mentioned "synergistic action" means that the antibacterial effect of the above-mentioned inorganic antibacterial agent and organic antibacterial agent on target cells is equal to or greater than the sum of the antibacterial effects of the aforementioned antibacterial agents.

The aforementioned antioxidant may comprise a phenoxyethanol compound, a benzoic acid compound, a sorbic acid compound, other suitable antioxidants, or any mixture of the above antioxidants. This antioxidant prevents the oxidative effects caused by skin secretions from affecting the antibacterial effect of the antibacterial compound. The antioxidant is used in an amount of from 0.1 part by weight to 1 part by weight based on 100 parts by weight of the second polylactic acid. In one embodiment, the antioxidant is used in an amount of from 0.2 part by weight to 0.5 part by weight based on 100 parts by weight of the second polylactic acid. If the amount of the antioxidant used is more than 1 part by weight, the prepared antibacterial layer does not meet the safety addition ratio as stipulated by government regulations. If the amount of the antioxidant used is less than 0.1 part by weight, the antioxidant effect of the prepared antioxidant is not good, and the above-mentioned protective effect against the antibacterial compound cannot be attained.

The degradable antibacterial biomedical multilayer film of the present invention can be produced by a co-extrusion process. The coextrusion process adds the aforementioned biodegradable composition to a co-extrusion molding machine, and sets the temperature of the co-extrusion molding machine to 160 ° C to 170 ° C to heat the biodegradable composition described above. When the above creatures are available After the decomposition composition is heated and melted, the screw in the co-extrusion molding machine pushes the molten state polymer out of the die in one direction to form the degradable antibacterial biomedical multilayer film of the present invention, wherein the degradable antibacterial raw material The longitudinal elongation at break of the medical multilayer film is not less than 200%, and the transverse elongation at break is greater than 100%.

The term "longitudinal" as used herein refers to a direction along the direction of the coextrusion process, and "lateral" refers to another direction that is perpendicular to the direction of the coextrusion process. The aforementioned "longitudinal direction" may also be referred to as a machine direction (MD), and the "lateral direction" may also be referred to as a transverse direction (TD). Furthermore, when the degradable antibacterial biomedical multilayer film is stressed and extended to break, the elongation of the multilayer film is the elongation at break, and the ratio of the elongation at break to the original length is the elongation at break.

In one embodiment, the coextrusion process described above may utilize blown film forming or extrusion molding to produce a degradable antimicrobial biofilm multilayer film. When the coextrusion process described above is formed by blown film formation, the polymer in the molten state of the extrusion die can be introduced into the gas by the air tube, so that the molten polymer forms a blow molded product. The blow molded article is a multilayer film cylinder. The multilayer film cylinder has a hollow structure, the outer layer of the multilayer film cylinder is a film layer, and the inner layer of the multilayer film is an adhesive layer. Wherein, as the circumference of the multilayer film cylinder increases, the blow molded article may extend in a direction perpendicular to the foregoing. In one embodiment, the outer layer of the multilayer film cylinder may be an adhesive layer, and the inner layer of the multilayer film cylinder is a thin film layer.

When the biodegradable antibacterial biomedical multilayer film of the present invention is produced by the co-extrusion process, the winding process can be simultaneously performed in the foregoing direction. When the winding process is carried out, the antibacterial biomedical multilayer film can be degraded by winding the reel. Extending along the aforementioned direction.

Therefore, by the above-mentioned co-extrusion process and winding process, the degradable antibacterial biomedical multilayer film can simultaneously perform biaxial stretching, thereby improving the crystallinity of the multilayer film, thereby improving the heat resistance and mechanical properties of the multilayer film (for example) : Impact strength and biaxial elongation). After the biaxial stretching, the heat-resistant temperature of the degradable antibacterial biomedical multilayer film produced by the present invention is not lower than 70 °C.

The term "biaxial elongation" as used in the present invention refers to the extension of the degradable antibacterial biomedical multilayer film in the longitudinal direction and the transverse direction. The definitions of "longitudinal" and "transverse" are the same as defined above, and are not described herein.

In one embodiment, the degradable antibacterial biomedical multilayer film of the present invention further comprises a release film, which can protect the adhesive layer and enhance the application convenience of the degradable antibacterial biomedical multilayer film. The release film system is disposed on the adhesive layer, and the adhesive layer is disposed between the release film and the aforementioned film layer. The release film system is formed of a third biodegradable composition, and the third biodegradable composition comprises a third polylactic acid, a plasticizer, a compatible compound, a nucleating agent, and a slip agent.

The third polylactic acid may include any combination of D-type polylactic acid, L-type polylactic acid, D, L-type polylactic acid or the above polylactic acid, and the third biodegradable composition has an average moisture content of not more than 200 ppm. If the average moisture content of the third biodegradable composition exceeds 200 ppm, the third polylactic acid contained therein is cleaved, and the release film is cracked and damaged, thereby being disadvantageous for the application of the degradable antibacterial biomedical multilayer film.

The plasticizer may comprise a polyol, a polybasic acid ester, a polyamidamine compound, a polyunsaturated polyester compound, a polyunsaturated polyether compound, other suitable plasticizers, or any mixture of the foregoing. Plasticizer can reduce material The rigidity of the material and the increase of its ductility. The plasticizer is used in an amount of from 0.1 part by weight to 25 parts by weight based on 100 parts by weight of the third polylactic acid. In one embodiment, the plasticizer is used in an amount of from 1 part by weight to 20 parts by weight based on 100 parts by weight of the third polylactic acid. If the amount of the plasticizer used is more than 25 parts by weight, the release film produced is not rigid and is not easy to process.

The compatible compound has a structure which readily forms a bond of a reactive functional group, and the compatible compound may comprise a peroxide, an epoxy type compound, an acrylic type compound, an isohydroate type compound, other suitable compatible compounds or the like Any combination of materials. Compatible compounds enhance the compatibility of the polylactic acid with the modified material and enhance the synergy between the aforementioned components. The compatibilizing compound is used in an amount of from 0.1 part by weight to 15 parts by weight based on 100 parts by weight of the third polylactic acid. In one embodiment, the amount of the compatible compound used is from 2 parts by weight to 12 parts by weight based on 100 parts by weight of the third polylactic acid. If the amount of the compatible compound used is more than 15 parts by weight, an excessively complex compound may undergo an excessive blending reaction to lower the physical and mechanical properties of the release film. If the amount of the compatible compound used is less than 0.1 part by weight, the third biodegradable composition may cause phase separation, and the release film may not be prepared.

The nucleating agent may comprise an aromatic sulfonic acid group metal compound, an aromatic metal phosphate compound, a phthalate compound, a fatty acid metal salt, an inorganic metal salt compound, and other suitable crystal nucleating agents. The crystal nucleating agent can form fine crystal nuclei to help the third biodegradable composition to crystallize, thereby improving the heat resistance and impact resistance of the prepared release film. Based on the amount of the third polylactic acid used The crystal nucleating agent is used in an amount of from 0.1 part by weight to 5 parts by weight per 100 parts by weight. In one embodiment, the amount of the crystal nucleating agent used is from 0.3 parts by weight to 3 parts by weight based on 100 parts by weight of the third polylactic acid. If the amount of the nucleating agent used is more than 5 parts by weight, the excessive nucleating agent lowers the impact resistance of the prepared release film and affects the application of the multilayer film. If the amount of the crystal nucleating agent used is less than 0.1 parts by weight, too little crystal nucleating agent lowers the heat resistance and impact resistance of the release film.

The aforementioned slip agent comprises a metal soap compound, a hard ester guanamine compound, a paraffin compound, other suitable slip agents or any combination of the above slip agents. The slip agent can impart a non-stick release effect to the material and cause slippage between the additive and the main material, so that the molecular chains are aligned to form crystals. The amount of the slip agent used is from 0.1 part by weight to 5 parts by weight based on 100 parts by weight of the third polylactic acid. In one embodiment, the amount of the slip agent used is from 0.3 parts by weight to 3 parts by weight based on 100 parts by weight of the third polylactic acid. If the amount of the slip agent used is more than 5 parts by weight, the prepared release film is difficult to process and affects the application of the release film. If the amount of the slip agent used is less than 0.1 part by weight, too little slipping agent cannot enhance the crystallinity of the third biodegradable composition.

When the user uses the multilayer film of the present invention, the user can first tear off the release film and apply the multilayer film to the wound through the adhesive layer of the multilayer film to protect the wound and avoid the effect of wound infection.

The following examples are used to illustrate the application of the present invention, and are not intended to limit the present invention, and various modifications and refinements can be made without departing from the spirit and scope of the invention.

Preparation of multilayer film Example 1

Preparation of a first biodegradable composition

First, 100 parts by weight of polylactic acid, 0.1 part by weight of an acrylic polyester compound, 0.1 part by weight of a crystallizing agent, and 0.1 part by weight of a plasticizer are added to a twin-screw kneader after a kneading granulation process. The first biodegradable composition can be obtained.

Preparation of a second biodegradable composition

The second biodegradable composition uses the same preparation method as the first biodegradable composition described above, except that the second biodegradable composition changes the kind and amount of the raw material, and the formulation thereof is as described As shown in Table 1, it will not be repeated here.

Preparation of multilayer film

The first biodegradable composition prepared above and the second biodegradable composition are placed at 90 ° C, and after drying for more than 4 hours, the moisture content of the biodegradable composition is less than 200 ppm. Then, the first biodegradable composition and the second biodegradable composition are respectively added to a co-extrusion molding machine at a temperature of 160 ° C to 170 ° C. When the first biodegradable composition and the second biodegradable composition are heated and melted, the screw in the co-extrusion molding machine pushes the molten state polymer out of the die in one direction and uses the air tube to pass through A gas causes the polymer in a molten state to form a blow molded article. Then, the above-mentioned blow molding product is subjected to a winding process to produce a multi-layer film. The evaluation results of the heat resistance temperature, impact strength, elongation at break and antibacterial effect of the obtained multilayer film are shown in Table 1, wherein the above evaluation knot The detection method of the fruit will be described later.

Examples 2 to 5

In the examples 2 to 5, the same production method as that of the multilayer film of the first embodiment was used, except that the examples 2 to 5 were used to change the kind and amount of the raw materials in the multilayer film, and the formulation and evaluation results were as follows. As shown in Table 1, it will not be repeated here.

Comparative example 1

In Comparative Example 1, the same production method as in the production method of Example 1 was used, except that Comparative Example 1 produced a single-layer film using only polylactic acid, and the evaluation results are shown in Table 1, and will not be further described herein. The polylactic acid used in the comparative examples was the same as in the examples.

Evaluation project

The impact strength, elongation at break, and heat resistance temperature of the multilayer films produced in Examples 1 to 5 and Comparative Example 1 were measured in accordance with ASTM D1709 test method, D882 test method, and D648 test method, respectively.

Next, the antibacterial effects of the multilayer films produced in Examples 1 to 5 and Comparative Example 1 were examined by a test method known to those skilled in the art to which the present invention pertains.

As can be seen from the results of the first table, the degradable antibacterial biomedical multilayer film of the present invention can be produced by a co-extrusion process, and the degradable antibacterial biomedical multilayer film of the present invention has a good antibacterial effect.

Furthermore, by the co-extrusion process and the winding process described above, the two-axis extension can improve the crystallinity of the degradable antibacterial biomedical multilayer film, but The mechanical properties of the multilayer film are improved, and the biaxial stretching property allows the multilayer film to be produced to have a heat resistance temperature of not lower than 70 °C. Therefore, the degradable antibacterial biomedical multilayer film of the present invention has good mechanical properties, and can prevent the multilayer film from being broken when the user exerts a force.

Further, the degradable antibacterial biomedical multilayer film of the present invention is produced by using a biodegradable plastic composition, so that the multilayer film of the present invention does not burden the environment when disposed, and does not generate toxic gas when incinerated.

The present invention has been disclosed in the above embodiments, and is not intended to limit the present invention. Any one of ordinary skill in the art to which the present invention pertains can make various changes without departing from the spirit and scope of the invention. The scope of protection of the present invention is therefore defined by the scope of the appended claims.

Claims (7)

A degradable antibacterial biomedical multilayer film comprising: a film layer formed of a first biodegradable composition, wherein the first biodegradable composition comprises: a first polylactic acid, wherein the first polylactic acid a weight average molecular weight of 80,000 to 300,000; a co-polymer, wherein the copolymer is obtained by copolymerizing an unsaturated polyester polymer and an acrylic compound, and the copolymer has at least one first reactive organic group Wherein the first reactive organic group is selected from the group consisting of an acrylic group, a carboxyl group, and any combination thereof; a crystallizing agent; and a plasticizer, and wherein the first polylactic acid is used based thereon The amount of the copolymer is from 0.5 part by weight to 20 parts by weight, the amount of the crystal promoter is from 0.1 part by weight to 5 parts by weight, and the amount of the plasticizer used is 0.1 part by weight. Up to 20 parts by weight; and an adhesive layer disposed on the film layer, wherein the adhesive layer is formed by a second biodegradable composition, and the second biodegradable composition comprises: a second poly Lactic acid, of which The second polylactic acid has a weight average molecular weight of 30,000 to 60,000; a polymer mixture, wherein the polymer mixture comprises a polyester polymer and a polyether polymer; a compatibilizing agent; an antibacterial compound; and an antioxidant, wherein the polymer mixture is used in an amount of 0.1 part by weight to 49 parts by weight based on 100 parts by weight of the second polylactic acid, the compatibilizing agent The amount used is from 0.1 part by weight to 2 parts by weight, the antibacterial compound is used in an amount of from 0.1 part by weight to 1 part by weight, and the antioxidant is used in an amount of from 0.1 part by weight to 1 part by weight. The degradable antibacterial biomedical multilayer film according to claim 1, wherein the one of the degradable antibacterial biomedical multilayer films has a longitudinal elongation at break of greater than or equal to 200% and less than or equal to 290%, and the degradable antibacterial agent One of the biomedical multilayer films has a transverse elongation at break of greater than 100% and less than or equal to 165%. The degradable antibacterial biomedical multilayer film according to claim 1, wherein the amount of the first polylactic acid used is 100 parts by weight, and the copolymer is used in an amount of 2 parts by weight to 12 parts by weight. The crystallizing agent is used in an amount of from 0.5 part by weight to 3 parts by weight, and the plasticizer is used in an amount of from 2 parts by weight to 15 parts by weight. The degradable antibacterial biomedical multilayer film according to claim 1, wherein the polymer mixture is used in an amount of 5 parts by weight to 25 parts by weight based on 100 parts by weight of the second polylactic acid. The amount of the compatibilizing agent used is from 0.2 parts by weight to 0.6 parts by weight, and the amount of the antibacterial compound used It is from 0.3 parts by weight to 0.8 parts by weight, and the antioxidant is used in an amount of from 0.2 part by weight to 0.5 part by weight. The degradable antibacterial biomedical multilayer film according to claim 1, further comprising: a release film disposed on the adhesive layer, wherein the adhesive layer is disposed on the release film and the film layer Between the release film is formed by a third biodegradable composition, and the third biodegradable composition comprises: a third polylactic acid; a plasticizer; a compatible compound; a nucleating agent; and a slip agent, wherein the plasticizer is used in an amount of 0.1 part by weight to 25 parts by weight based on the third polylactic acid used in an amount of 0.1 part by weight, and the compatible compound is used in an amount of 0.1 part by weight. The amount of the crystal nucleating agent used is from 0.1 part by weight to 5 parts by weight, and the amount of the slip agent used is from 0.1 part by weight to 5 parts by weight. The degradable antibacterial biomedical multilayer film according to claim 5, wherein the plasticizer is used in an amount of from 1 part by weight to 20 parts by weight based on 100 parts by weight of the third polylactic acid. The compatible compound is used in an amount of 2 parts by weight to 12 parts by weight, the nucleating agent is used in an amount of 0.3 parts by weight to 3 parts by weight, and the amount of the slip agent used is 0.3 parts by weight to 3 parts by weight. Share. The degradable antibacterial biomedical multilayer film according to claim 1, wherein the one of the degradable antibacterial biomedical multilayer films has a heat resistance temperature of greater than or equal to 70 ° C and less than or equal to 82 ° C.