TW201941798A - Intelligent negative pressure wound therapy system - Google Patents

Abstract

An intelligent negative pressure wound therapy system includes a foam-type wound dressing, a negative-pressure controller for specifying a supply pressure value and controlling an output pressure supplied to the foam-type wound dressing to create negative-pressure environment; and a pressure sensor electrically coupled to the negative-pressure controller for detecting pressure changes within the negative-pressure environment. If the pressure within the negative-pressure environment exceeds the supply pressure value, the pressure sensor sends a signal to the negative-pres sure controller for adjustment of the output pressure supplied. Thereby the pressure within the negative environment maintains at a value under the supply pressure value. The negative pressure wound therapy system of the disclosure monitors the pressure changes at all times and adjusts the pressure to a value under the supply pressure value, such that the foam-type wound dressing forms a substantially tight seal over a wound.

Description

Intelligent control negative pressure wound system

The invention relates to a negative pressure wound control system which can monitor and adjust the negative pressure at any time, and allows the negative pressure foam dressing to be completely tightly sealed in the wound.

According to the Taiwan Diabetes Association: At present, there are about 150 million people with diabetes in the world, which is the chronic disease with the fastest increase in incidence in the 21st century. It is estimated that the number of patients will exceed 300 million in the future. Diabetic foot ulcers not only affect the quality of life of patients, but also pose a major challenge to the medical team. Many studies have confirmed that Negative Pressure Wound Therapy (NPWT) can be used on complex wounds to promote the growth of granulation tissue, absorb excess fluid, help wound healing, prevent tissue infections, and reduce the chance of amputation in patients with diabetic foot.

Negative pressure wound treatment is a very effective treatment tool for patients with chronic wounds. In recent years, the clinical penetration rate of NPWT has become higher and higher, and more and more patients have benefited; therefore, relative, More and more users have raised the problems and complications encountered in the clinical use of NPWT. For example, the current NPWT is filled with a sponge-like polyurethane (Polyurethane; PU) dressing into the wound, and then buried in a suction tube for suction. Finally, it is adhered with a gas-impermeable film (such as 3M Tegaderm), and suction is started. . Such a use process often makes the user feel quite troublesome and troublesome when cutting the dressing and filling the wound. In addition, in the last step of pasting the air-tight adhesive film, users often complained that they could not be tightly adhered, leading to air leakage. They must repeatedly perform the "catch-leak" and sticking actions, which caused great problems in use.

The structure of a common negative pressure wound treatment device is, for example, the patent case of the invention No. I615163 “Closed Wound Diversion Device” published on February 21, 107 of the Republic of China, which discloses that the device can be in two forms. 1: An irregular foamed medicated covering material, a diversion tube, a collection tank, and a pressure source; Form 2: a planar foamed medicated covering material, a diversion tube, a collection tank, and a pressure Its function is to cover the wound. When the pressure source acts, it acts as a guide to promote cell growth and accelerate wound healing. Its operation method covers the wound with an irregular or flat foaming medicated covering material to make the adhesive Apply the layer to the normal skin, then connect the drainage tube to the collection tank and connect the pressure source. When the pressure source is activated, the irregular or flat foaming medicated covering material is attached to the wound surface to accelerate wound healing; during the treatment period Observe the wound from the window, if necessary, rinse or inject the medicine through the flushing cavity to make the wound recover.

Because the pre-patent case does not monitor the pressure change of the negative pressure output at any time, once the pressure changes due to air leakage, it cannot be immediately detected and disposed of, which will cause the pressure of the negative pressure output to be insufficient. At the same time, it is not possible to choose a suitable pressure value setting mode according to the different injuries of the clinical wound. If the wound is a deep recess with a submerged depth and an irregular shape, there is often a problem of poor adhesion of the dressing to the wound. At the same time, when the dressing is removed, the problem of fasciitis or bleeding is caused by the breakage or sticking of the dressing. However, the dressing of the pre-patent case must first be cut to an appropriate size according to the shape of the wound, so it will cause a waste of time in wound treatment.

There is also a patent case of Invention No. I597080 "Negative Pressure Therapy Device" announced on September 1, 106, Republic of China, which disclosed that it includes a filling material and an airtight unit. The material of the filling material is a hydrophilic polyurethane foam, which is obtained by foaming a hydrophilic polyurethane and a foaming component, and the holes of the hydrophilic polyurethane foam are discontinuous closed holes, and the hydrophilic Polyurethane is a star-shaped block polyurethane obtained by reacting a first polyether polyol with a polyisocyanate, and then reacting with a second polyether polyol and hyaluronic acid. The first polyether polyol contains at least three terminal hydroxyl groups. . The airtight unit covers the filling material to form a wound space that is substantially sealed and contains the filling material. The negative pressure treatment device does not need to cut and trim the filling material multiple times before being placed in the wound, which can effectively promote wound healing and avoid the injury caused by sticking when removing and replacing.

However, the pre-patent case also does not have a device for monitoring the pressure change of the negative pressure at any time, so it is also not ideal in use.

Therefore, it is considered that the conventional negative pressure wound treatment device has the above-mentioned disadvantages. Therefore, the present invention provides a smart negative pressure control wound system, including: a negative pressure foam dressing; and a negative pressure controller, which can set a delivery pressure value to control and output a pressure to the negative pressure foam dressing To make the negative pressure foam dressing produce a negative pressure environment; a pressure sensor is connected to the negative pressure controller by a signal, and the pressure sensor is arranged on the negative pressure foam dressing to sense the negative pressure at any time The pressure changes in the pressure environment. When the pressure exceeds the conveying pressure value, the pressure sensor controls the negative pressure controller to adjust the output pressure, so that the negative pressure environment is maintained within the range of the conveying pressure value. Inside.

The above-mentioned negative pressure foam dressing uses 2 to 2.5 mol of diisocyanate, 0.1 to 1 mol of hydrophilic polyol, 0.5 mol of polydimethylsiloxane-polyoxyalkylene copolymer, 0.1 mol of ethylenediamine, and 0.1 mol of caprylic acid It is a foam material which is operated at 25 ~ 50ºC for 3 minutes and then foamed and poured.

The above-mentioned negative pressure foam dressing is made through the procedures of a chemical thermal reaction, a foam flow, a foam solid and a surface anti-sticking treatment, respectively, after foaming and infusion.

The above-mentioned negative pressure foam dressing has a water swelling ratio of> 800%, a water retention rate of> 50%, a water vapor transmission rate of ≥1500 g / m ² to 24 hrs, a density of 0.15 to 0.20 g / cm ³ , and a thermal cracking temperature of > 200 ° C, resilience is> 15%, and ductility is 35% ~ 45%.

The invention further includes a transmission unit, which is connected to the negative pressure controller for transmitting the transmission pressure value and the pressure data to a remote device for monitoring and a cloud database for big data. Analysis and integration.

The surface edge of the negative pressure foam dressing is covered with an airtight member to maintain the airtightness of the negative pressure environment.

The above-mentioned negative pressure controller provides a cyclic negative pressure mode. The pressure value setting of the cyclic negative pressure mode is divided into four modes. The first mode is continuous pressure suction wound, which continuously gives negative pressure -125mmHg; The two modes are intermittent pressure suction wounds. First, a negative pressure of -125mmHg is applied for 5 minutes, and then a 2 minute rest mode is entered. 0mmHg is a cycle. The third mode is dynamic, and the negative pressure cycle is dynamically given at 3 A negative pressure of -125mmHg is reached in minutes, and then it returns to -25mmHg as a cycle in 3 minutes. The fourth mode is a cyclic mode, which is interactive selection based on the first mode, the second mode, and the third mode. use.

The cyclic negative pressure mode includes the first mode and the second mode. When the cyclic negative pressure mode reaches the first mode, the pressure is continuously provided. When the cyclic negative pressure mode reaches the second mode, the The negative pressure controller will continuously pump at the negative pressure for 5 minutes, then rest and release the pressure for 2 minutes.

The negative pressure controller is provided with a negative pressure tube in communication with the negative pressure foam dressing, and the negative pressure controller is provided with a display screen for displaying the pressure and the conveying pressure value output by the negative pressure controller. .

The pressure output by the negative pressure controller is between -40mmHg and -140mmHg.

The above technical features have the following advantages:

1. It can monitor the pressure change of the negative pressure conveyance at any time, so once the pressure changes or the pressure output is abnormal due to air leakage, it can immediately detect and adjust the negative pressure controller so that the pressure can be maintained at the set conveyance. Within the pressure range. The use of negative pressure can promote the growth of granulation tissue, absorb excess exudate, and help wound healing, prevent tissue infection, and reduce the chance of amputation in patients with diabetic foot.

2. The negative pressure foam dressing itself has a high swelling rate, which can be absorbed after contact with the exudate of the wound, and expand rapidly, so that it can deform itself according to the shape of the wound, so that the negative pressure foam dressing can Completely tight in the wound.

Please refer to the first and second figures. The embodiment of the present invention includes a negative pressure foam dressing (1), a negative pressure controller (2), a pressure sensor (3), and a transmission unit (4). among them:

Negative pressure foam dressing (1), which uses 2 to 2.5 mol of diisocyanate, 0.1 to 1 mol of hydrophilic polyol, 0.5 mol of polydimethylsiloxane-polyoxyalkylene copolymer (surfactant), 0.1 mol of ethyl The foam material synthesized by diamine (crosslinking agent) and octanoic acid (catalyst) is operated at 25 ~ 50ºC for 3 minutes, and then is made into the negative pressure foam dressing (1) through foaming infusion, as described in Section See three pictures. The negative pressure foam dressing (1) can be manufactured through procedures such as a chemical thermal reaction, a foam flow, a foam solidification and a surface anti-adhesion treatment. And by adjusting the ratio between the hydrophilic polyol and the ethylenediamine, the water absorption swelling ratio of the negative pressure foam dressing (1) (g / g)> 800% (DIN EN13726 ~ 1Part3.2 /3.3), water retention rate (g / g)> 50% (DIN EN13726 ~ 1Part3.2), water vapor transmission rate (g / m ² ~ 24hrs) ≥1500g / m ² ~ 24hrs (ASTM E96 ~ 93BW ), Density is 0.15 ~ 0.20g / cm ³ (ASTM D792), thermal cracking temperature is> 200 ° C (ASTM D3850), resilience is> 15% (ASTM D3574), ductility is 35 ~ 45% (ASTM D41275) And other characteristics. When it is packed in a wound (B), it can quickly absorb the exudate of the wound (B) and swell, so that it can cooperate with the shape of the wound (B) to deform itself, and completely fits in the wound (B ) To adjust the characteristics required for clinical negative pressure wound treatment. The surface of the negative pressure foam dressing (1) is covered with an airtight member (11), so as to maintain the airtightness of the negative pressure foam dressing (1), the airtight member (11) may be an airtight Film.

The negative pressure controller (2) is provided with a negative pressure tube (21) and communicates with the negative pressure foam dressing (1). The negative pressure controller (2) can be used to set a conveying pressure value, and then according to the conveying pressure value, the negative pressure controller (2) can control the negative pressure pipe (21) to output a pressure to the negative pressure foam The dressing (1) causes the negative pressure foam dressing (1) to create a negative pressure environment.

The negative pressure controller (2) is a negative pressure suction pump capable of providing a cyclic negative pressure mode. The negative pressure controller (2) can set a delivery pressure value from -40mmHg to -140mmHg. The negative pressure controller (2) is provided with a display screen (22) for displaying the pressure output by the negative pressure controller (2) to the negative pressure environment and the set delivery pressure value. The negative pressure controller (2) uses a battery as a source of power.

In addition, the pressure value setting of the cyclic negative pressure mode is divided into four types for interactive selection. The first type is continuous pressure suction wound, and a fixed negative pressure (-125mmHg) is continuously given to the wound dressing. Two types are intermittent pressure suction wounds. First, a fixed negative pressure (-125mmHg) is applied for 5 minutes, and then a 2 minute rest mode (0mmHg) is entered for one cycle. The third type is dynamic. , Give the negative pressure cycle dynamically, reach a specific negative pressure (-125mmHg) within 3 minutes, and then return to a smaller negative pressure (-25mmHg) as a cycle within 3 minutes; the fourth is a circulation mode, combining the above multiple modes cycle.

Therefore, the cyclic negative pressure mode of the embodiment of the present invention includes a continuous mode and an intermittent mode, which are mixed and used by using the first continuous type and the second intermittent type described above. When the cyclic negative pressure mode of the negative pressure controller (2) proceeds to the continuous mode, the pressure that provides negative pressure is continuously supplied to the wound (B), and when it proceeds to the intermittent mode, the negative pressure controller (2) The pressure will be changed. After 5 minutes of continuous suction with negative pressure, rest and release the pressure for 2 minutes.

A pressure sensor (3), whose signal is connected to the negative pressure controller (2), the pressure sensor (3) can be set in the negative pressure foam dressing (1) to sense the negative pressure at any time The pressure change in the pressure environment, when the pressure exceeds the delivery pressure value set by the negative pressure controller (2), the pressure sensor (3) will output a signal to the negative pressure controller (2 ) To adjust the output pressure to ensure that the negative pressure environment of the wound (B) is maintained within the range of the delivery pressure value.

A transmission unit (4) is connected to the negative pressure controller (2) for transmitting the pressure value and the pressure data to a remote device (C) for monitoring and a cloud database ( D) Perform big data analysis and integration. The remote device (C) can be a smart phone, a tablet computer, a personal computer, or a notebook computer held by medical personnel, users, caregivers and other related personnel. The transmission unit (4) can transmit data through the Internet, mobile communication network, Wi-Fi, ZigBee or Bluetooth.

During use, as shown in the first and second figures, the negative pressure foam dressing (1) is stuffed on the wound (B), and then the surface edge of the negative pressure foam dressing (1) is covered. The airtight member (11) is used to maintain the airtightness in the negative pressure environment of the negative pressure foam dressing (1). The negative pressure foam dressing (1) is a special porous open foam, which uses diisocyanate, hydrophilic polyol, polydimethylsiloxane-polyoxyalkylene copolymer (surfactant), and ethylenediamine. (Crosslinking agent) Synthesized with octanoic acid (catalyst). By applying negative pressure on the wound (B), the wound surface can be evenly reduced by negative pressure, and it can also play the role of drainage, while filling local defects and removing too much. The exudate of the wound reduces the edema of the tissue surrounding the wound (B) by providing the wound (B) with a relatively humid environment, and stimulates the growth of granulation tissue. In this way, it is different from the way in which the dressing used in the conventional practice must be cut into an appropriate size and then packed into the wound. In the embodiment of the present invention, the negative pressure foam dressing (1) itself has a high degree of swelling, and is absorbed after contacting with the exudation of the wound (B) and deforms itself according to the shape of the wound (B). , So that the negative pressure foam dressing (1) can be swelled in the wound (B) and quickly and completely adhered.

Then, by activating the negative pressure controller (2), the delivery pressure value of the negative pressure is set, so that the negative pressure controller (2) can output the pressure to the negative pressure foam through the negative pressure pipe (21). Dressing (1). The negative pressure controller (2) is used with the negative pressure foam dressing (1) to form the negative pressure environment. After the negative pressure foam dressing (1) is stuffed into the wound, the negative pressure tube (21) starts to be negative. The vacuum suction is used to remove the excess exudate, infectious substances, and necrotic tissue fragments of the wound (B) by the negative pressure generated, and the cyclic negative pressure mode of the negative pressure is continuous mode and intermittent mode. The delivery The maximum pressure value can be as low as -140mmHg.

Then, the pressure sensor (3) can sense the pressure change in the negative pressure environment at any time, so that when the pressure exceeds the delivery pressure value set by the negative pressure controller (2), the pressure feeling The detector (3) will output the signal to the negative pressure controller (2), so as to adjust the delivery pressure value so that the pressure is maintained within the range of the delivery pressure value, thereby ensuring the negative pressure of the wound (B). The pressure environment is maintained under a certain pressure.

At the same time, the transmission unit (4) will transmit the delivery pressure value to the remote device (C) to monitor the healing or infection status of the wound (B). Once the pressure exceeds the delivery pressure value, such as air leakage If the pressure is abnormal, a warning will be issued to notify the relevant personnel located at the remote device (C) for repair or treatment, which can prevent the wound (B) from worsening due to delayed treatment. And can be transferred to the cloud database (D) for big data analysis and integration, for other related units as a reference when treatment.

The present invention has been tested by animals to prove that it can be implemented. The test content is shown below.

(a) In the first year, rabbits, pigs and other animals (E) were used as animal wound healing models. Rabbits and pigs are medium and large animals in animal experiments. It is more convenient to use rabbits for testing and observation. After obtaining preliminary results, pigs are used as animal wound healing models. Although the experimental pigs are more expensive, they have been used for research and development for a long time. Their genetics, physiology, anatomy, nutrition, and breeding knowledge and technology have been very mature and closer to humans, so they have become the most preclinical animal experiments. Good option.

Negative Pressure Wound Therapy (NPWT) is used in the treatment of Lanyu pigs. It creates a circular full-thickness skin wound with a diameter of 5cm on both sides of the spine on the back of Lanyu pigs. There are 10 wounds on the left and right sides. After the wound was created, the wound was gently pressed with gauze moistened with 0.9% physiological saline to stop bleeding, and two adjacent (opposite) wounds were used as a group. The dressing was changed on the 2nd and 5th days of the experiment. The negative pressure treatment system [negative pressure controller (2) and pressure sensor (3)] was connected to the pressure monitoring system [remote device (C)] and was on duty. Staff visits to minimize interruptions in treatment. The wound was photographed and recorded on day 0, 2, 5, and 7 and the area and depth of the wound were measured. On day 7, the wound was euthanized. Take off the wound and the whole layer of skin tissue, and use tissue sections with different staining methods to observe the wound healing after using the dressing.

(b) Use the intelligent control negative pressure wound system in the process of animal wound healing to observe the effects of cell differentiation, function, and secretion of cytokines and their mechanisms. Remove the small piece of tissue at the wound, add Trizol and a few steel balls to homogenize it for RNA purification, observe the differentiation and function of cells in the wound through the amplification of PCR, and the secretion of cytokines in each wound healing stage to understand the polyurethane Changes in dressings on stem cells and endothelial cells undergoing differentiation stimulation, gene expression, cytokine secretion, and functional testing. COX2, IL1-β, and TNF-α can be used to observe the inflammatory response, and CD31 can be used to observe the response of angiogenesis to promote wound healing.

(c) Promote chronic wound healing in diabetic rats with intelligent control of negative pressure wound system in the second year. In chronic wound healing, the wound healing process is blocked due to certain adverse factors such as infection and foreign bodies. The healing time is more than three months, which is called chronic wound. Reference to a previously established diabetic rat model in the laboratory (Hsueh et al., 2016) simulates the effect of chronic wounds that are difficult to heal after being covered with a drug release dressing to promote wound healing. After fasting for 48 hours, SD rats (270-300g) were injected intraperitoneally. Animals in the diabetic group received intraperitoneal injection of Streptozotocin (STZ) 70 mg / kg (STZ in citrate buffer, pH 4.5) daily for 21 consecutive days. Rats need to fast for 8 hours after injection. After STZ injection, the blood glucose and weight of each rat were observed and recorded daily. The diabetes status of the rats was confirmed by monitoring, and the blood glucose increased to more than 250 mg / dl. This confirms the successful induction of diabetic rats.

In the process of wound healing, it is divided into the inflammatory phase, the proliferative phase, and the repair phase. A large number of cells need to be aggregated for tissue regeneration in the wound area. Dressing changes were performed 5 days. After sacrificing the Lanyu pig and removing the skin, different staining methods of tissue sections were used to observe the wound healing after using the dressing. Skin and wound tissue sampling and analysis At five sampling time points (days 0, 2, 5, and 7), skin, muscle, and adipose tissue samples were taken from the wounds. And on the 28th day, the mice were sacrificed, and the skin tissue at the wound was removed. After fixing the above tissue samples with 4% paraformaldehyde, the specimens were dehydrated in a series of increasing alcohols, and then replaced with xylene. Soak in paraffin. The paraffin specimen was cut into 10 micron thick slices using a slide microtome, and the slices were flattened in a warm water bath and placed on a glass slide. Place the slides on a baking tray at 40 ° C overnight to help the section adhere to the slides. After that, the slides containing the sections were gradually replaced with water in xylene and alcohol, and the dewaxing step was performed. The dewaxed samples were subjected to the following staining analysis.

(c1) Hematoxylin & eosin (H & E) stain staining: comparing the differences in wound inflammation and composition between different groups.

(c2) Masson's trichrome stain: observe whether the composition of the collagen fibers has changed. The collagen in the normal place appears as blue low tension collagen (COL) and the wound shows red high tension. Collagen (High tension COL). The image processing software was used to quantify Mason's trichrome staining images to confirm the changes in high tension and low tension collagen.

(c3) immunohistochemistry (IHC): observe the inflammatory cytokines interleukin-1 (IL-1), interleukin-6 (IL-6), and IL-6 are pre-inflammatory cytokines and anti-inflammatory Type I cytokines, and collagen type I collagen I, observe the wound epidermal healing.

The invention has proved to be very effective after the above-mentioned animal tests. In the future, it will be started with actual clinical tests on humans in medical institutions (F), so as to prove that the invention can indeed achieve the above-mentioned effects.

Based on the description of the above embodiments, the operation, use and effects of the present invention can be fully understood, but the above-mentioned embodiments are only preferred embodiments of the present invention, and the implementation of the present invention cannot be limited in this way. The scope, that is, the simple equivalent changes and modifications made according to the scope of the patent application and the description of the invention, are all within the scope of the present invention.

(1) ‧‧‧Negative pressure foam dressing

(11) ‧‧‧Airtight parts

(2) ‧‧‧Negative pressure controller

(21) ‧‧‧Negative pressure tube

(22) ‧‧‧Display screen

(3) ‧‧‧Pressure sensor

(4) ‧‧‧Transmission unit

(A1) ‧‧‧ Mixing Mixer

(A2) ‧‧‧Mould Cavity

(B) ‧‧‧ wound

(C) ‧‧‧Remote device

(D) ‧‧‧Cloud Database

(E) ‧‧‧Animal

(F) ‧‧‧Medical Institution

[First Figure] This is a schematic diagram of the configuration and use of the embodiment of the present invention.

[Second figure] is a schematic diagram of wound treatment used in the embodiment of the present invention.

[Third figure] is a simple manufacturing flow chart of a negative pressure foam dressing according to an embodiment of the present invention.

Claims (10)

A smart negative pressure control wound system includes: a negative pressure foam dressing; a negative pressure controller that can set a delivery pressure value to control outputting a pressure to the negative pressure foam dressing, so that the negative pressure The pressure foam dressing generates a negative pressure environment; a pressure sensor is connected to the negative pressure controller by a signal, and the pressure sensor is arranged on the negative pressure foam dressing to sense the pressure in the negative pressure environment at any time. The pressure changes. When the pressure exceeds the conveying pressure value, the pressure sensor controls the negative pressure controller to adjust the output pressure so that the negative pressure environment is maintained within the range of the conveying pressure value. As described in item 1 of the scope of patent application, the negative pressure control wound system is intelligent, wherein the negative pressure foam dressing uses 2 to 2.5 mol of diisocyanate, 0.1 to 1 mol of hydrophilic polyol, and 0.5 mol of polydimethylsiloxane -Polyoxyalkylene copolymer, 0.1mol ethylenediamine and 0.1mol octanoic acid octanoate. It is a foamed material which is operated at 25 ~ 50ºC for 3 minutes and then foamed and poured. As described in item 2 of the scope of the patent application, the negative pressure control wound system is intelligent, wherein after the negative pressure foam dressing is foamed and perfused, it passes through a chemical thermal reaction, a foam flow, and a foam solidification respectively. And a surface anti-sticking process. As described in item 1 of the scope of patent application, the negative pressure control wound system is intelligent, wherein the swelling rate of the negative pressure foam dressing is> 800%, the water retention rate is> 50%, and the water vapor transmission rate is ≥1500g / m ² ~ 24hrs, density 0.15 ~ 0.20g / cm ³ , thermal cracking temperature is> 200 ° C, resilience is> 15%, and ductility is 35% ~ 45%. According to the intelligent control negative pressure wound system described in the first item of the patent application scope, a transmission unit is further provided, and the transmission unit is connected to the negative pressure controller for transmitting the pressure value and the pressure data. To a remote device for monitoring and a cloud database for big data analysis and integration. As described in item 1 of the scope of the patent application, the negative pressure control wound system is intelligent, wherein the surface edge of the negative pressure foam dressing is covered with an airtight member to maintain the airtightness of the negative pressure environment. As described in item 1 of the scope of the patent application, the intelligent control negative pressure wound system, wherein the negative pressure controller provides a cyclic negative pressure mode, and the pressure value setting of the cyclic negative pressure mode is divided into four modes, the first type The mode is continuous pressure suction wound, continuous negative pressure is given to -125mmHg; the second mode is intermittent pressure suction wound, first given negative pressure -125mmHg suction for 5 minutes, and then enter the 2 minute rest mode 0mmHg is One cycle; the third mode is dynamic, and the negative pressure cycle is dynamically given to reach negative pressure -125mmHg within 3 minutes, and then returns to -25mmHg within 3 minutes as a cycle; the fourth mode is cycle mode, which combines The first mode, the second mode, and the third mode are used alternately. As described in item 7 of the scope of patent application, the negative pressure control wound system is intelligent, wherein the cyclic negative pressure mode includes the first mode and the second mode, and the cyclic negative pressure mode proceeds to the first mode. At that time, the pressure will be continuously provided. When the second mode is reached, the negative pressure controller will continuously suck at the negative pressure for 5 minutes, then rest and release the pressure for 2 minutes. As described in item 1 of the scope of patent application, the negative pressure control wound system is intelligent, wherein the negative pressure controller is provided with a negative pressure tube to communicate with the negative pressure foam dressing, and the negative pressure controller is provided with a display A screen for displaying the pressure and the delivery pressure value output by the negative pressure controller. According to the intelligent control negative pressure wound system described in the first item of the patent application scope, wherein the pressure output by the negative pressure controller is between -40mmHg and -140mmHg.