201208712 六、發明說明： 【發明所屬之技術領域】 本發明係關於一種皮膚化妝品。進而詳細而言，關於一 種肌膚粗糙改善用.皮膚化妝品，其藉由調配D·胺基酸或者 其衍生物或其鹽之1種或2種以上、磷脂醯膽鹼之含量為％ 質量％以上之氫化碟脂質、及水溶性多元醇而於肌膚粗糖 防止或者改善方面具有優異之效果。 【先前技術】 肌膚粗㈣由於乾燥、紫外線、清潔劑或化學物質等刺 激性物質等外在重要因f，或激素平衡之奮亂等内在重要 因素而產生之肌膚困擾’並伴隨角質層屏障功能之下降、 角質層水分量之下降、表皮代謝回轉之宄進、鱗屑之產生 (鱗屑，scaling)而角質粗糙化等現象。尤其角 化’亦有時使妝面服帖變差，成為很多女性美容方面之煩 先則’為改善肌膚粗缝，可使用藉由凡士林軟膏或油中 水型乳化製劑等閉塞劑而彌補角質層屏障功能的方法，藉 由山梨糖醇或甘油、環氧烧街生物等保濕劑而補充角質層 水分量的方法，藉由廿苴a 4夂專消炎藥而消解皮膚炎症的 方法，藉由維生辛、激去镗ζ ^ 專利文獻卜5)。 ^活化皮膚細胞的方法（參照 然而，如上所述之先前方法有如下缺點：其任一者之皮 膚水分保持能力均不充分， 不僅角質改善效果較少，尤苴 使用閉塞劑之情形時較為 ^ ,、 由腻，帶來黏糊糊等令人不快之 J56749.doc 201208712 觸感。另一方®，·fc/vAfc 於使用保濕劑之情形時亦為提高效果而 必須大量調配，装紝 再、，，α果為，有帶來黏糊糊感或滑膩感等令 人不快之觸感的pq 寸 、、4碭。進而，於使用胎盤等動物組織之萃 取物或維生紊、、如主& 午 、激素專之情形時，於與副作用等相關之安 全性或經時穋定枝古；士 a 關之女 疋^方面有問題。尤其，關於角質之粗糙 化’角質之剝離未順利地進行之狀況已明確，但並無適當 之對策。 另方面，作為卵礙脂之主成分之填脂質係作為生物膜 之構成成分而為人所知，正作為對皮膚之親和性較佳、安 全性較高之源自天然、之界面活性劑而用於皮膚化妝品等 中。尤其，由於其界面活性能之性質，作為乳化劑、增黏 劑、及凝膠化劑之利用度較高。然而，根據通常之天然鱗 脂質中不飽和脂肪酸之含量較高，故而對於氧化或熱不穩 定，又乳化能力或凝膠化能力亦不充分等，因此使用對磷 脂質實施氫化之氫化磷脂質。 關於將氫化磷脂質用作化妝品之基劑，自先前起進行種 種研究。作為具體例，可列舉：藉由氫化磷脂質使水凝膠 化所得之基劑（例如，專利文獻6)、藉由氫化磷脂質及特定 之非離子性界面活性劑及水所調製之凝膠化基劑（例如， 專利文獻7)、於由虱化4脂質及甘油及油劑調製之凝膠令 添加水而獲得乳化組合物之方法（例如，非專利文獻丨）等。 然而，藉由添加上述氫化磷脂質所得之凝膠化基劑係藉 由均質授拌機等之機械剪力而製造並確保凝膠組合物之穩 定性者。因此，將該技術工業化時有必需巨額之設備投 156749.doc 201208712 資、其維持費用亦增多之問題。x，該設備運轉時之電能 肩耗亦增大’於對環境問題之關心提高之近來之時勢下並 非理想的方法》 進而，甘油所代表之於分子内具有2個以上羥基之水溶 性多元醇作為賦予肌膚或毛髮滋潤度或濕满、或者賦予肌 膚彈力感之保濕劑而作為皮膚化妝品等之原料為不可或 缺，但為充分獲得該效果，必需較高之調配量。然而，若 水溶性多元醇之調配量提高，則亦有雖然保濕效果提高， 但同時亦產生黏腻感等缺點之問題。 [先前技術文獻] [專利文獻] [專利文獻1]曰本專利特開平6_293625號公報 [專利文獻2]日本專利特開平7_277943號公報 [專利文獻3]日本專利特開平9_95432號公報 [專利文獻4]曰本專利第3660656號公報 [專利文獻5]曰本專利特開2009-227645號公報 [專利文獻6]曰本專利特開昭62-93239號公報 [專利文獻7]日本專利第2660540號公報 [非專利文獻] [非專利文獻1]松本哲治等，Fragrance Journal，1998年3 月號，p41-48 【發明内容】 [發明所欲解決之問題] 本發明係鑒於上述先前技術之問題而完成者，其課題在 156749.doc 201208712 於提供一種肌膚粗糙改善用皮膚化妝品，其改善肌膚粗糙 尤其角質之粗糙化、乾燥，調整肌膚紋理，實現光滑之肌 膚，又’安全性、穩定性及觸感方面亦優異。 [解決問題之技術手段] 本發明者等為解決上述課題而進行努力研究，結果發現 藉由將D-胺基酸或者其衍生物及/或其鹽種或2種以 上、磷脂醢膽鹼之含量為50質量％以上之氫化磷脂質之i 種或2種以上、及水溶性多元醇組合而調配，可獲得解決 上述課題之皮膚化妝品；從而完成本發明。 即’本發明提供一種肌膚粗糙改善用皮膚化妝品，其特 徵在於含有：（A)D_胺基酸、其衍生物及/或鹽之1種或2種 以上’（B)磷脂醯膽鹼之含量為5〇質量％以上之氫化磷脂質 之1種或2種以上，及（〇水溶性多元醇。 [發明之效果] 根據本發明可提供一種肌膚粗糙改善用皮膚化妝品，其 改D肌膚粗縫尤其角質之粗縫化、乾燥，調整肌膚紋理， 貫現光滑之肌膚，又，安全性、穩定性及觸感方面亦優 異0 【實施方式】 以下’對本發明進行詳細敍述。 本發明之皮膚化妝品必須含有D_胺基酸、其衍生物及/ 或鹽之1種或2種以上（(A)成分：以下有時略稱為「d胺基 酸類」）。 如眾所周知，胺基酸中作$光學異構物而存在l體及d I56749.doc • 6 · 201208712 體，天然之蛋白質為L-胺基酸進行肽結合者。一般認為， 除了細菌之細胞壁等一部分例外以外’於以人為代表之哺 礼類之體内僅存在L-胺基酸，生體僅利用L_胺基酸。因此 先則，學術上或者產業上引人注目而經研究之胺基酸僅為 L-胺基酸。 作為例外使用D-胺基酸之事例，可列舉：〇)作為細菌 中產生之抗生素之原料之情形，（2)含有於在化學合成胺基 酉文時為節省自等量獲得之L_胺基酸與D_胺基酸混合物（消 方疋體）僅分取L-胺基酸的成本而直接作為DL•胺基酸混合物 而調配的食品添加物中之情形等。 最近，明確人亦隨著年齡增加，原本應該不存在於眼之 晶狀體、腦、或者皮膚等中之D_天冬醯胺酸（D_Asp，d_ Asparaginic Acid)增加，對其與白内障或阿茲海默症之發 病之關係等進行討論（木野内忠稔等，「蛋白質核酸酶」 第50卷’第5號（2005年）453-560頁）。於皮膚中亦發現藉由 老化或务' 外線照射而累積D_Asp，提出將D_Asp作為用以 識別老化或紫外線引起之皮膚損傷的分子標記物而應用 (藤井紀子’美容研究報告，第13號（2⑽5年）。然而，未知 將D-胺基酸積極地用作生理活性物質的例子。 本發明之特徵在於如下方面：將先前由於如上所述之情 況而未調配於化妝品、尤其皮膚化妝品中的D-胺基酸作為 必需成分而調配。 本發明中使用之D-胺基酸類（⑷成分）只要為⑽則並無 特別限定’但較佳為其本身發現肌膚改善效果者。具體而 I56749.doc 201208712 s，可列舉確認有抗氧化效果、膠原蛋白產生促進效果之 D-天冬酿胺酸’確認有層黏連蛋白332產生促進效果、膠 原蛋白產生促進效果之D-丙胺酸’確認有屏障恢復功能、 皺紋形成減輕效果、肌膚粗糙減輕效果之〇_穀胺酸，確認 有紫外線損傷減輕效果之D-絲胺酸，確認有層黏連蛋白 332產生促進效果之D_羥基脯胺酸，確認有紫外線損傷減 輕效果之D-半胱胺酸，確認有紫外線損傷減輕效果之心甲 硫胺酸及D-脯胺酸，確認有黑色素生成抑制效果之D_羥基 脯胺酸等。 本發明中使用之D-胺基酸類可為合成者亦可為市售品。 作為D-胺基酸之製造方法，例如已知使源自細菌之〇_胺 基醯化酶作用於醯化胺基酸而獲得之方法等（參照日本專 利特開平11-113592號公報）。 本發明之皮膚化妝品中之D_胺基酸類的調配量較佳為相 對於化妝品總量設為〇.1〜5 0質量％。未達〇丨質量％時，獲 得作為本發明之特徵之無黏腻感'肌膚改善效果優異之化 妝品較為困難，即便超過5.〇質量％而調配亦無法獲得作為 本發明之效果之肌膚改善效果之進一步增強。 繼而，對本發明中磷脂醯膽鹼之含量為5〇質量％以上之 氫化蛾脂質（成分（B))進行詳細敍述。 本發明中之氫化磷脂質之特徵在於磷脂醯膽鹼之含量為 50質ΐ %以上。若磷脂醯膽鹼之含量未達5〇質量。、，則存 在產生缺乏對水溶性多元醇之溶解性、保濕性亦較差、作 為化妝品氣味變差等問題之情形。 156749.doc 201208712 作為本發明中使用之填脂醯膽鹼（以下pc (Phosphatidylcholine))之含量為50質量％以上之氫化磷脂 質的具體例’例如可列舉：大豆卵磷脂、蛋黃卵磷脂、或 者该專之純化物或氫化物等。可使用市售品，例如可列 舉.COATSOME NC-21(PC含量90%以上，日本油脂股份 有限公司製造）、COATSOME NC-61(PC含量60%以上，曰 本油脂股份有限公司製造）、NIKKOL Resinol S-10X(PC含 量75〜85%，Nikko Chemicals股份有限公司製造）、 NIKKOL Resinol S-10EX(PC 含量 95°/。以上，Nikk〇 Chemicals 股份有限公司製造）、NIKK〇L Resin〇1 s i〇m (PC含量55〜650/〇，Nikko Chemicals股份有限公司製造）、201208712 VI. Description of the Invention: TECHNICAL FIELD OF THE INVENTION The present invention relates to a skin cosmetic. Further, in detail, the skin cosmetic preparation is prepared by blending D or amino acid or a derivative thereof or a salt thereof with one or more kinds, and the phospholipid choline content is % by mass or more. The hydrogenated disc lipid and the water-soluble polyol have an excellent effect in preventing or improving the skin's raw sugar. [Prior Art] Skin is thick (4) Skin troubles caused by external factors such as dryness, ultraviolet rays, detergents, chemicals, and other irritating substances, such as f, or hormone balance, and the stratum corneum barrier function The decline, the decrease in the water content of the stratum corneum, the hypermetabolism of the epidermal metabolism, the scaling (scaling) and the roughening of the keratin. In particular, keratinization sometimes makes the makeup look worse, and it becomes the trouble of many women's beauty. 'To improve the rough skin, you can make up the stratum corneum by using an occlusive agent such as petroleum jelly or oil-based emulsified preparation. A method of barrier function, which is a method for replenishing the moisture of the stratum corneum by a humectant such as sorbitol or glycerin or an epoxy-burning creature, and a method for digesting skin inflammation by using a 消a 4夂 anti-inflammatory drug, by dimension Sheng Xin, radical 镗ζ ^ Patent Literature 5). ^Method of activating skin cells (Reference, however, the prior method as described above has the following disadvantages: the skin moisture retention ability of either of them is insufficient, and not only the keratin improvement effect is small, but also the case where an occlusive agent is used is more ^ , the greasy, sticky and other unpleasant J56749.doc 201208712 touch. The other side, · fc / vAfc in the case of using moisturizer also to improve the effect must be a large number of deployment, decoration, The alpha fruit is a pq inch, 4 砀 which brings an unpleasant touch such as a slimy feeling or a slippery feeling. Further, an extract or a living bacterium of an animal tissue such as a placenta is used, such as a main & In the case of noon or hormones, the safety related to side effects, etc., may be fixed in the past; the female 疋 关 士 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 The situation is clear, but there is no appropriate countermeasure. On the other hand, the lipid-filling system, which is the main component of the egg yolk, is known as a component of the biofilm, and is more suitable for skin and has better safety. high It is derived from natural surfactants and used in skin cosmetics, etc. In particular, due to its interfacial activity properties, it is highly utilized as an emulsifier, a tackifier, and a gelling agent. The natural squama lipid has a high content of unsaturated fatty acid, so it is unstable to oxidation or heat, and has insufficient emulsifying ability or gelling ability. Therefore, a hydrogenated phospholipid which hydrogenates a phospholipid is used. As a base for cosmetics, various studies have been conducted from the past. Specific examples thereof include a base obtained by hydrogelation of a hydrogenated phospholipid (for example, Patent Document 6), hydrogenated phospholipids, and A specific nonionic surfactant and a gelation base prepared by water (for example, Patent Document 7), a gel prepared from deuterated 4 lipid, glycerin, and an oil agent, and water is added to obtain an emulsified composition. A method (for example, Non-Patent Document No.), etc. However, the gelation base obtained by adding the above hydrogenated phospholipid is produced by a mechanical shear force of a homogenizer or the like and ensures a gel. Therefore, when the technology is industrialized, there is a huge amount of equipment required to invest 156749.doc 201208712, and its maintenance costs are also increasing. x, the shoulder energy consumption of the equipment is also increased during operation The concern about environmental issues is not an ideal method in recent times. Further, glycerin represents a water-soluble polyol having two or more hydroxyl groups in the molecule as a moisturizing or moisturizing skin or hair, or a feeling of elasticity to the skin. The moisturizing agent is indispensable as a raw material for skin cosmetics and the like, but in order to sufficiently obtain the effect, a high blending amount is required. However, if the blending amount of the water-soluble polyol is increased, the moisturizing effect is improved, but at the same time [Patent Document 1] [Patent Document 1] Japanese Patent Laid-Open No. Hei 7-277943 (Patent Document 3) Japanese Patent Publication No. Hei 9-95432 (Patent Document 4), Japanese Patent No. 3660656 (Patent Document 5), Japanese Patent Laid-Open Publication No. 2009-227645 [Patent Document 6] Japanese Patent Publication No. 2660540 [Non-Patent Document] [Non-Patent Document 1] Matsumoto Tetsuji, etc., Fragrance Journal, March 1998 P41-48 [Problem to be Solved by the Invention] The present invention has been made in view of the problems of the prior art described above, and the subject of the present invention is to provide a skin cosmetic for improving skin roughness, which improves skin roughness, in 156749.doc 201208712 In particular, the keratin is rough and dry, and the skin texture is adjusted to achieve a smooth skin, which is also excellent in safety, stability and touch. [Means for Solving the Problem] The inventors of the present invention have made an effort to solve the above problems, and as a result, it has been found that D-amino acid or a derivative thereof and/or a salt thereof or two or more kinds thereof, phospholipid choline The skin cosmetic of the above-mentioned problem can be obtained by combining i or two or more kinds of hydrogenated phospholipids having a content of 50% by mass or more and a water-soluble polyol, and the present invention has been completed. In other words, the present invention provides a skin cosmetic for improving skin roughness, which comprises: (A) one or more kinds of D-amino acids, derivatives and/or salts thereof ('B) phospholipid choline One or two or more kinds of hydrogenated phospholipids having a content of 5% by mass or more, and (a water-soluble polyol). [Effect of the Invention] According to the present invention, it is possible to provide a skin cosmetic for improving skin roughness, which is modified to be rough In particular, the keratin is rough and smooth, and the skin texture is adjusted to achieve smooth skin. It is also excellent in safety, stability and touch. [Embodiment] The present invention will be described in detail below. The cosmetic must contain one or two or more kinds of D_amino acids, derivatives and/or salts thereof ((A) component: hereinafter sometimes referred to as "d-amino acid"). As is well known, amino acids are known. For the optical isomer, there is a l-body and d I56749.doc • 6 · 201208712. The natural protein is L-amino acid for peptide binding. It is generally considered that except for some exceptions such as the cell wall of bacteria Representative gift There is only L-amino acid in the body, and the organism uses only L-amino acid. Therefore, the academic or industrially attractive amino acid is only L-amino acid. Examples of the D-amino acid include 〇) as a raw material of an antibiotic produced in bacteria, and (2) a L-amino acid obtained by saving an equivalent amount in chemically synthesizing an amine group. The D_amino acid mixture (deuterated body) is a food additive which is directly formulated as a mixture of DL•amino acid, and the like, by taking only the cost of the L-amino acid. Recently, it has been clarified that with the increase of age, D_aspartic acid (D_Asp, d_Asparaginic Acid) which should not exist in the lens, brain, or skin of the eye increases, and it is associated with cataract or Azhai. The relationship between the onset of morbidity and the like is discussed (Muye Nai, et al., "Protein Nucleases", Vol. 50, No. 5 (2005), pp. 453-560). It is also found in the skin that D_Asp is accumulated by aging or external exposure, and D_Asp is proposed as a molecular marker for identifying skin damage caused by aging or ultraviolet rays. (Fuji Kikoko's Beauty Research Report, No. 13 (2(10)5) However, it is not known to actively use D-amino acid as an example of a physiologically active substance. The present invention is characterized by the following aspects: D which has not been previously formulated in cosmetics, especially skin cosmetics, due to the above-mentioned circumstances - Amino acid is used as an essential component. The D-amino acid (component (4)) used in the present invention is not particularly limited as long as it is (10), but it is preferred to find a skin improving effect by itself. Specifically, I56749.doc 201208712 s, D-aspartic acid which confirms the anti-oxidation effect and the collagen production-promoting effect, and D-alanine, which confirms the effect of promoting the adhesion of laminin 332 and promoting the production of collagen, confirms that there is a barrier. Recovery function, wrinkle-reducing effect, skin roughness reduction effect _ glutamic acid, D-serine which confirms the effect of reducing UV damage, indeed D-hydroxyproline which has a promoting effect on laminin 332, D-cysteine which has a UV-damage-reducing effect, and methionine and D-proline which have the effect of reducing ultraviolet damage, D-hydroxyproline or the like having a melanin production inhibitory effect is confirmed. The D-amino acid used in the present invention may be a synthetic or a commercially available product. As a method for producing a D-amino acid, for example, it is known A method of obtaining a bacterium based on a bacterium, which is obtained by the action of a hydrazine-based hydrazine-degrading enzyme, and the like. (refer to Japanese Laid-Open Patent Publication No. Hei 11-113592.) The preparation of D_amino acid in the skin cosmetic of the present invention The amount is preferably set to 〇1 to 50% by mass based on the total amount of the cosmetic. When the amount is less than 5% by mass, it is difficult to obtain a cosmetic having excellent skin-improving effect as a characteristic of the present invention. When the amount is more than 5% by mass, the skin-improving effect of the present invention is further enhanced. Further, in the present invention, the content of the phospholipid choline is 5% by mass or more of the hydrogenated moth lipid (ingredient (B) ) detailed The hydrogenated phospholipid in the present invention is characterized in that the content of phospholipid choline is 50% by mass or more. If the content of phospholipid choline is less than 5 〇 mass, there is a lack of water-soluble polyol. In the case of the problem of the solubility of the cosmetic odor, etc. 156749.doc 201208712 Hydrogenated phospholipids having a content of 50% by mass or more of the choline (hereinafter referred to as pc (Phosphatidylcholine)) used in the present invention Specific examples of the quality include soybean lecithin, egg yolk lecithin, or a purified product or a hydride. The commercially available product can be used, for example, COATSOME NC-21 (PC content of 90% or more, Japan) Oil and Fats Co., Ltd.), COATSOME NC-61 (PC content of 60% or more, manufactured by Sakamoto Oil Co., Ltd.), NIKKOL Resinol S-10X (PC content: 75 to 85%, manufactured by Nikko Chemicals Co., Ltd.), NIKKOL Resinol S-10EX (PC content 95 ° /. Above, manufactured by Nikk〇 Chemicals Co., Ltd., NIKK〇L Resin〇1 s i〇m (PC content 55~650/〇, manufactured by Nikko Chemicals Co., Ltd.),
Basis LP-6〇HR(PC含量 62〜68%，Nisshin 〇im〇股份有限 公司製造）等。於本發明中，可將該等之丨種或2種以上適 當組合而使用。 關於本發明中使用之成分（B)磷脂醯膽鹼之含量為5〇質 量％以上之氣化碟脂質的調配量，較佳為相對於皮膚化妝Basis LP-6〇HR (PC content 62 to 68%, manufactured by Nisshin 〇im〇 Co., Ltd.). In the present invention, these or the like may be used in combination of two or more kinds as appropriate. The blending amount of the gasified disc lipid in which the content of the component (B) phospholipid choline used in the present invention is 5 〇 mass% or more is preferably relative to the skin makeup.
156749.doc 醉’並無特別限定，但 二丙二醇、丙二醇、二 201208712 甘油、異戊二醇、聚乙二醇、1，2-戊二醇等。本發明中， 較佳為將該等之1種或2種以上組合而使用。 本發明中之水溶性多元醇的含量較佳為相對於皮膚化妝 品總量設為5,0〜20.0質量％。未達5.〇質量％時，獲得作為 本發明之特徵之無黏腻感、肌膚改善效果優異之化妝品較 為困難，即便超過20_0質量％而調配，作盍士欲 ^本發明之效果 之肌膚改善效果亦並不進一步增強。 於本發明之皮膚化妝品中，較理想為除了上述必需成分 (AMC)外，並且進一步含有磷脂醯膽鹼之含量為5〇質量％ 以上之氫化磷脂質（成分以外之磷脂質， 性磷脂質。藉由調配酸性磷脂質，乳化時對 得更佳。 具體而言為酸 水之分散性變 作為本發明中使狀酸性㈣f，例如可列舉1脂酿 肌醇（PI，Phosphatidylinositol)、磷脂醯絲胺酸（ps， Phosphatidylsedne)、罐脂酿甘油（pG，ph〇sphat刪奶⑽^、 磷脂酸（PA，Ph〇Sphatidicacid)、M鱗脂醯肌醇、溶血破 脂醯絲胺酸等。本發明中，可將該等之丨種或2種以上與上 述必需成分（B)磷脂醯膽鹼之含量為5〇質量％以上之氫化磷 脂質適當組合而使用。作為酸性鱗脂質之調配量，較佳為 相對於皮膚化妝品總量設為〇.丨〜丨〇質量％。 本發明之肌膚粗糙改善用皮膚化妝品可為如下任一者： 非礼化型、或者水相成分為連續相並藉由常法以均化器等 攪拌混合而製造之水中油型之乳化型、或者油相成分為連 、.貝相之油令水型之乳化型' 或者複合多相乳液。水相成分 156749.doc 201208712 係於水或者以水為主成分之水相中含有各種水溶性成分 者水相成刀較佳為以相對於乳化之皮膚化妝品 50.0〜80.0質量％之古斗^ 里。之方式而凋配者。水相成分未達5〇〇質量 %時’存在感覺厚重、產生黏腻感之情形，另一方面，若 超過8 0 · 0質量％，目丨丨亡、主 里 則有吩清爽但不滋潤，不易獲得作為本 發明之效果之較高之肌膚改善效果。 於本發明之水中油型乳化化妝品中’於上述必需成分及 酸性麟脂質之外’可於不損害本發明之效果之範圍内適當 調配通常可調配於乳化化妝品中之任意成分。 作為該種任意成分’例如可列舉：紫外線吸收劑、紫外 =散射劑、蟻類、烴油、脂肪酸醋、聚石夕氧油、水溶性高 子门級醇回級脂肪酸、藥劑等，但並不限定於該 作為紫外線吸收劑，例如可列舉：對胺基苯甲酸、對甲 氧基肉桂酸辛醋(對甲氧基肉桂酸2_乙基己醋）、甘油單_2_ 乙基己醯基·_對曱氧基肉桂酸酯、i甲氧基桂皮酸曱基 雙（三曱基碎氧院）㈣基異戊醋等桂皮酸系紫外線吸收 片J 2’2 _說基_5-曱基笨基苯并三唾、2_(2'_經基-5'-第三辛 基苯基）苯并二唑、2-(2’-羥基_5’-甲基苯基）苯并三唑、4_ 曱氧基-4-第二丁基二苯甲醯曱烷、5_(3,3_二甲基_2-亞降 冰片烯基H-戊烷-2·酮、雙-乙基己氧基苯酚_甲氧基苯基_ 一井、2,4,6-二[4-(2-乙基己氧基羰基）苯胺基]心二^三 啡、二咮啉基噠嗪酮、2-乙基己基·2_1基_3,3·二苯基丙烯 酸酯等。 156749.doc 201208712 &作為紫外線散射劑，例如可列舉平均粒徑1〇〜〗〇〇 之 仏；'·氧化鈦、微粒氧化辞、微粒氧化鐵、微粒氧化飾等粉 末。 !又’藉由甲基氫化聚石夕氧炫或石夕垸偶合劑等聚石夕氧處 二金屬皂處理，全氟烷基磷酸二乙醇胺鹽或全款烷基矽 ①等氟處理’糊精脂肪酸酯處理等’經疏水化處理之紫外 線散射劑亦可根據劑型而適當調配。 作^類，例如可列舉：蜂躐、堪地里拉蟻、巴西標搁 蠟、羊毛脂、液狀羊毛脂、荷荷包蠟等。 作為烴油，例如可列舉：液態石鐵、地·磁响、 2纽、姥齩燒、石€、地蠛（ceresin)、角㈣、凡士 林、微晶蠟、聚乙烯蠟、費托蠟等。 作為脂肪酸酯，可列裹. 图醢护认 歹澤·综橺酸十六烷基酯、硬脂酸膽 固w、蜂蠟脂肪酸2_辛基十二烷基醋等。 作為聚石夕氧油，例如可 . 了列舉.鏈狀聚矽氧烷（例如，二 楚、一矽氧烷、子基苯基聚矽氧烷、二苯基聚矽氧烷 二、環狀料氧峨基環心^十二^ 二：氧烷寻)、形成三維網狀結構之聚矽氧樹脂、平均 为子里20萬以上之聚石夕蔔德磡 访与 氧橡勝、各種改性聚石夕氧烧（胺基 文性聚石夕氧烧、聚驗改丨 & u f生聚矽氧烷、烷基改性聚矽氧烷、 氟改性聚矽氧烷等）等。 作為水溶性高分子，彳丨 露聚糖士 “。可列舉：鹿角菜膠、果膠、甘 路知糖、卡德闌多糖、硫 —軟月素、澱粉、肝糖、阿拉伯 膠、玻尿酸納、黃蓍麟、 夕二仙膠、硫酸黏多糖、羥乙基瓜 156749.doc 201208712 爾膠it甲基瓜爾膠、瓜爾膠、葡聚糖、硫酸角質、刺槐 豆膠、琥珀醯聚糖、甲殼素、殼聚糖、羧甲基甲殼素、瓊 脂等。 . 作為高級醇，可列舉己醇、辛醇、十六烷醇、硬脂醇、 蠟醇、山籥醇、三十烷基醇、沙油醇、鯊肝醇等。 作為咼級脂肪酸，可列舉月桂酸、肉豆蔻酸、棕櫚酸、 硬脂酸、山荼酸等。 作為藥劑，例如可列舉：L·抗壞血酸及其衍生物之鹽、 傳明酸及其衍生物之鹽、烷氧基水揚酸及其衍生物之鹽、 麩胱苷肽及其衍生物之鹽等；更具體而言，作為L_抗壞血 酉文衍生物’可列舉：L-抗壞血酸單硬脂酸酯、L-抗壞血酸 單棕櫚酸酯、L-抗壞血酸單油酸酯等L_抗壞血酸單烷基酯 類’ L-抗壞血酸單磷酸酯、l—抗壞血酸_2_硫酸酯等L_抗壞 血酸單酯類，L-抗壞血酸二硬脂酸酯、L-抗壞血酸二棕櫚 酸醋、L-抗壞血酸二油酸酯等L_抗壞血酸二烷基酯類，L_ 抗壞血Ssl二硬脂酸醋、L-抗壞血酸三標桐酸醋、L-抗壞血 酸二油酸酯等L-抗壞血酸三烧基酯類，L-抗壞血酸三磷酸 酯等L-抗壞血酸三酯類，L-抗壞血酸2-葡糖苷等L-抗壞血 酸葡糖苷類等。於本發明中，以L-抗壞血酸、L-抗壞血酸 ' 磷酸酯、L-抗壞血酸-2-硫酸酯、L-抗壞血酸2-葡糖苷之各 鹽之形式而較佳地使用。 作為傳明酸衍生物，可列舉：傳明酸之二聚物（例如， 鹽酸反式-4-(反式-胺基曱基環己烷羰基）胺基甲基環己烷 羧酸等）、傳明酸與對苯二酚之酯體（例如，4-(反式-胺基 156749.doc -13· 201208712 甲基裱己烷羧酸）4’-羥基苯酯等）、傳明酸與龍膽酸之酯體 (例如，2-(反式-4-胺基甲基環己基羰氧基）_5_羥基苯曱酸 等）、傳明酸之醯胺體（例如，反式_4_胺基甲基環己烷羧酸 甲基酿胺、反式_4·(對甲氧基苯曱酿基）胺基甲基環己烧缓 酸、反式-4-胍基甲基環己烷羧酸等）等。本發明中以傳明 酸之鹽或者傳明酸衍生物之鹽之形式而較佳地使用。 烷氧基水楊酸係水揚酸之3位、4位或5位之任一氫原子 由烷氧基取代者，作為取代基之烷氧基，較佳為甲氧基、 乙氧基、丙氧基、#丙氧基、丁氧基、異丁氧基之任一 者，進而較佳為甲氧基或乙氧基。若具體例示化合物名， 則可列舉.3_ T氧基水楊酸、3·乙氧基水揚酸' 心甲氧基 水楊酸、4-乙氧基水揚酸、4_丙氧基水揚酸、‘異丙氧基 水楊酸、4-丁氧基水楊酸、5_甲氧基水楊酸、5_乙氧基水 楊酸、5-丙氧基水楊酸等。於本發明中以烷氧基水楊酸及 其衍生物（酯等）之各鹽之形式而較佳地使用。 作為上述藥劑之鹽，並無特別限定，例如，除了鈉鹽、 鉀鹽、鈣鹽等鹼金屬鹽或鹼土金屬鹽之外，可列舉：銨 鹽、胺基酸鹽等鹽。 又，亦可調配維生素A、維生素A棕櫊酸酯、維生素A乙 酸酯等維生素A衍生物，維生素&鹽酸鹽、維生素心三棕 櫚酸酯、維生素Βί二辛酸醋、維生素匕及其衍生物、維I 素Bu、維生素及其衍生物等維生素Β類，心生育酚、卜 生育酚、維生素Ε乙酸酯等維生素£類，維生素1)類，維生 素Η，泛酸，泛硫乙胺等維生素類；γ-榖維素，尿囊素， I56749.doc -14· 201208712 ^酉:（鹽）’甘草次酸，甘草次酸十八烧基醋，搶木醇， ’又樂醇’桉樹酮，瑞香草酚’肌醇，柴胡皂苷、人蔘皂 芽、絲瓜東接、& + ^ 甘無患子皂苷等皂苷類，泛醇乙醚，熊果 苦千金藤素等各種藥劑；羊蹄草、苦參、萍蓬草、橙、 尾草洋考草、錦葵、當藥、百里香、當歸、雲杉、樺 :賊、絲瓜、七葉樹、虎耳草、黃芩、山金車'百 J又草芍藥、蘆薈、梔子、櫻葉等植物萃取物；卜胡 蘿蔔素等色素等。 八他可列舉·乙醇等低級醇，丁基羥基甲苯、δ-生育 紛、非丁等抗氧化劑，苯甲酸、水揚酸、山梨酸、對經基 苯甲酸烷基醋、苯氧基乙醇、六氣酚、ε_聚離胺酸等心 劑’擰檬酸、乳酸、六偏填酸等有機或無機酸及其鹽等。 作為本發明之水令油型乳化皮膚化妝品的具體形態，可 列舉：乳液、潤膚霜、髮乳、粉底液、眼線液、睫毛膏、 眼影等礼液狀或者霜狀之製品，但並不限定於該等例示。 [實施例] 以下列舉實施例對本發明進而具體地進行說明，但本發 明並不爻该等貫施例之任何限定。再者只要未特別標記調 配量均為質量％。 ° 首先’對本實施例中使用之試驗方法、評價方法進行說 明。 。 關於製造法，使氫化磷脂質於1，3- 丁二醇、甘油等多_ 醇117於70C下;谷解而調製水相。繼而，於7〇。〇下货製士勺 地溶解之油相，一面於先前之水相中使用均質攪拌機，一 156749.doc -15· 201208712 面緩緩添加，乳化結束後，冷卻至3〇〇C，進行脫氣、過 濾’獲得目標之樣品。 (1) 穩定性試驗（氣味） 以官能觀察將試樣於5(TC下放置i個月後的氣味，並根 據下述評價基準進行評價。 (評價基準） 〇 :完全未見變味。 △.可感覺到一點變味但為容許範圍内。 X:見變味且其超過容許範圍。 (2) 肌膚粗檢改善效果 被檢驗者係為肌膚粗糙而煩惱之20〜50歲女性，各組30 人，將實施例或者比較例之霜於臉之面頻部連用2週。根 據被檢驗者自身之報告對肌膚㈣改善效果進行評價。評 價係依據下文所示之評價基準，藉由效果顯著、有效、稍 稱有效、無效4個等級進行，並藉由顯示效果顯著 效、稍稍有效之比率（有效率）表示。 又’取皮膚表面形態之印模，利用顯微鏡（Η倍）觀察， 並依據表1所*之基準對肌膚粗㈣態進行評價。 <評價基準> 效果顯著：肌膚之乾燥全無，獲得光滑之觸感。 有效：肌膚之乾燥減少，光滑之觸感增加。 稍稍有效：肌膚之乾燥減少。 無效：肌膚之乾燥無變化，或變差。 156749.doc •16· 201208712 [表l] 評分 評分之基準 1 溝表皮、脊表皮消失，大範圍之角質層捲縮 2 溝表皮、脊表皮不清晰，角質層捲縮 3 溝表皮、脊表皮不可見，但平坦 4 溝表皮、脊表皮清晰 5 溝表皮、脊表皮清晰且整齊 (3)使用性（使用時無黏腻感） <評價基準> ◎:回答無黏膩感之人為25人以上 〇:回答無黏腻感之人為20〜24人 △:回答無黏腻感之人為15〜19人 x:回答無黏腻感之人為14人以下 [表2] 成分名 實施例 1 2 3 4 5 (1)離子交換水 剩餘 剩餘 剩餘 剩餘 剩餘 (2)D-丙胺酸[(A)成分] 0.1 3.0 5.0 1.0 0.1 (3)甘油[(C)成分1 5.0 10.0 15.0 5.0 10.0 (4)1,3-丁二醇[(C)成分】 3.0 3.0 3.0 3.0 3.0 (5)氫化磷脂質(PC含量為90%以上）* 1[(B)成分】 0.1 1.0 3.0 5.0 3.0 ⑹苯氧基乙醇 0.5 0.5 0.5 0.5 0.5 (7)氫化聚異丁烯 5.0 5.0 5.0 5.0 5.0 156749.doc •17- 201208712 ⑻異十六烧 5.0 5.0 5.0 5.0 5.0 (9)凡士林 2.0 2.0 2.0 2.0 2.0 (10)十六烷醇 2.0 2.0 2.0 2.0 2.0 (11)硬脂酸甘油酯 2.5 2.5 2.5 2.5 2.5 (12)三硬脂酸山梨糖醇酐酯 0.2 0.2 0.2 0.2 0.2 (13)肉豆蔻酸肉豆蔻酯 2.0 2.0 2.0 2.0 2.0 (14)硬脂醇 0.2 0.2 0.2 0.2 0.2 (15)山蝓醇 0.3 0.3 0.3 0.3 0.3 (16)乙二胺四乙酸鹽 0.1 0.1 0.1 0.1 0.1 (17)(二曱基丙烯醯胺/丙烯醯基二曱基牛 磺酸納)交聯共聚物 0.3 0.3 0.3 0.3 0.3 ⑴穩定性(氣味） 〇 〇 〇 〇 〇 (2)<肌膚粗糙改善效果> 效果顯著 4 6 6 7 5 有效 5 8 13 13 5 稍稍有效 12 9 6 6 12 無效 9 7 5 4 8 (肌膚粗糙改善有效率） 70.0 76.7 83.3 86.7 73.3 <印模評分> 1 0 0 0 0 0 2 1 0 0 0 1 3 9 10 6 9 9 4 19 7 15 15 19 5 1 3 9 6 1 (3)使用性(黏腻感） ◎ ◎ 〇 ◎ 〇 * 1 :商品名：COATSOMENC-21(曰本油脂股份有限公司製造) 156749.doc -18- 201208712 [表3] 成分名 比較例 1 2 3 4 5 (1)離子交換水 剩餘 剩餘 剩餘 剩餘 剩餘 (2)D-丙胺酸[(A)成分] - 0.1 0.1 - - (3)甘油[(C)成分】 5.0 - 10.0 - 15.0 (4)1,3-丁二醇[(C)成分】 3.0 3.0 3.0 3.0 3.0 (5)氫化磷脂質(PC含量為90°/。以上）木 1【(B)成分] 0.1 0.1 - - - (6)苯氧基乙醇 0.5 0.5 0.5 0.5 0.5 (7)氫化聚異丁烯 5.0 5.0 5.0 5.0 5.0 ⑻異十六烷 5.0 5.0 5.0 5.0 5.0 (9)凡士林 2.0 2.0 2.0 2.0 2.0 (10)十六烷醇 2.0 2.0 2.0 2.0 2.0 (11)硬脂酸甘油酯 2.5 2.5 2.5 2.5 2.5 (12)三硬脂酸山梨糖醇酐酯 0.2 0.2 0.2 0.2 0.2 (13)肉豆蔻酸肉豆蔻酯 2.0 2.0 2.0 2.0 2.0 (14)硬脂醇 0.2 0.2 0.2 0.2 0.2 (15)山崎醇 0.3 0.3 0.3 0.3 0.3 (16)乙二胺四乙酸鹽 0.1 0.1 0.1 0.1 0.1 (17)(二甲基丙烯醯胺/丙烯醯基二曱基牛 磺酸納)交聯共聚物 0.3 0.3 0.3 0.3 0.3 (1)穩定性(氣味） 〇 〇 0 〇 〇 (2)<肌膚粗糙改善效果> 效果顯著 0 0 3 0 1 有效 3 1 4 0 1 稍稱有效 7 3 5 2 17 無效 20 16 18 28 1 (肌膚粗糙改善有效率） 33.3 13.3 40.0 6.7 43.3 156749.doc -19- 201208712156749.doc Drunken is not particularly limited, but dipropylene glycol, propylene glycol, two 201208712 glycerin, isoprene glycol, polyethylene glycol, 1,2-pentanediol and the like. In the present invention, one type or two or more types are used in combination. The content of the water-soluble polyol in the present invention is preferably from 5,0 to 20.0% by mass based on the total amount of the skin cosmetic. When it is less than 5% by mass, it is difficult to obtain a cosmetic which is excellent in the skin-improving effect and has an excellent skin-improving effect, and it is formulated to be more than 20% by mass. The effect is not further enhanced. In the skin cosmetic of the present invention, it is preferable to contain a hydrogenated phospholipid (phospholipid or a phospholipid other than the component) in addition to the above-mentioned essential component (AMC) and further containing a phospholipid choline content of 5% by mass or more. When the acidic phospholipid is blended, the emulsification is more preferable. Specifically, the dispersibility of the acid water is changed as the acidity (IV) f in the present invention, and for example, 1 phenolic inositol (PI, Phosphatidylinositol), phospholipid silk is used. Amino acid (ps, Phosphatidylsedne), canned glycerin (pG, ph〇sphat milk (10)^, phosphatidic acid (PA, Ph 〇 Sphatidic acid), M squamous inositol, hemolytic, sputum, lysine, etc. In the present invention, the above-mentioned or a mixture of two or more kinds of hydrogenated phospholipids having a content of the above-mentioned essential component (B) phospholipid choline of 5% by mass or more may be used in combination as appropriate. Preferably, the total amount of the skin cosmetic is set to 〇.丨~丨〇% by mass. The skin cosmetic for skin roughness improvement of the present invention may be any of the following: an indecent type, or an aqueous phase component is a continuous phase and often An oil-based emulsified type produced by stirring and mixing with a homogenizer or the like, or an oil-phase emulsified type or a composite multi-phase emulsion of an oil-phase component. The aqueous phase component is 156749.doc 201208712 The water phase forming knives in the water phase containing water or water as a main component are preferably those which are in the form of 50.0 to 80.0% by mass of the emulsified skin cosmetic. When the water phase component is less than 5% by mass, there is a case where the feeling is heavy and the feeling of stickiness is generated. On the other hand, if it exceeds 80% by mass, the eyes are dead, and the main part is bright but not moisturized. It is not easy to obtain a skin-improving effect which is a high effect of the present invention. In the oil-in-water emulsion cosmetic of the present invention, 'besides the above-mentioned essential components and acidic linum lipids' can be appropriately prevented from deteriorating the effects of the present invention. The compounding agent can be arbitrarily formulated as an optional component in the emulsified cosmetic. Examples of the optional component include ultraviolet ray absorbing agent, ultraviolet ray scatter agent, ant class, hydrocarbon oil, fatty acid vinegar, polyoxime oil, and water-soluble. The high-grade alcohol-grade fatty acid, the drug, and the like are not limited to the ultraviolet absorber, and examples thereof include p-aminobenzoic acid and p-methoxycinnamic acid octyl vinegar (p-methoxycinnamic acid 2_B). Base vinegar), glycerol mono-2-_ethylhexyl decyl _ 曱 methoxy cinnamate, i methoxy cinnamic acid bismuth (triterpene oxyhydrogenate) (tetra) ketoic acid Ultraviolet absorption sheet J 2'2 _ said base _5- fluorenyl benzotrisole, 2_(2'-transyl-5'-t-octylphenyl) benzodiazole, 2-(2' -hydroxy- 5'-methylphenyl)benzotriazole, 4-decyloxy-4-second butyl benzhydrane, 5-(3,3-dimethyl-2-norbornene H-pentane-2·one, bis-ethylhexyloxyphenol_methoxyphenyl_yijing, 2,4,6-bis[4-(2-ethylhexyloxycarbonyl)aniline Heart bis trimorphine, dioxalinyl pyridazinone, 2-ethylhexyl 2_1 _ 3,3 · diphenyl acrylate, and the like. 156749.doc 201208712 & As the ultraviolet ray scattering agent, for example, 平均 having an average particle diameter of 1 〇 to 〇〇 仏; '· titanium oxide, fine particle oxidized words, fine particle iron oxide, fine particle oxidized decoration, and the like. And 'reagent treatment with polyoxophosphoric acid diethanolamine salt or full-range alkyl hydrazine 1 by methyl hydrogenated polysulfide or oxime coupling agent The hydrophobized ultraviolet scattering agent such as the treatment of the fine fatty acid ester can also be appropriately formulated according to the dosage form. As the class, for example, bee sting, anterior ant, Brazilian standard wax, lanolin, liquid lanolin, jojo wax, and the like can be cited. Examples of the hydrocarbon oil include liquid stone iron, ground magnetism, 2 New Zealand, simmering, stone, ceresin, horn (four), petrolatum, microcrystalline wax, polyethylene wax, Fischer-Tropsch wax, and the like. . As a fatty acid ester, it can be listed. Figure 醢 认 · · · · · 橺 橺 橺 橺 橺 橺 橺 橺 十六 十六 十六 十六 十六 十六 十六 十六 。 。 。 。 。 。 。 。 。 。 。 。 。 。 As the polyoxime oil, for example, a chain polyoxyalkylene (for example, a sulfonium, a monooxane, a phenylphenyl polyoxyalkylene, a diphenyl polyoxy siloxane, a ring) may be mentioned.峨 峨 环 ^ ^ ^ ^ ^ ^ ^ ^ 2 oxane), the formation of three-dimensional network structure of polyoxyn oxy-resin, the average of more than 200,000 of the collection of the stone Shi Xi De visit and oxygen oak win, various changes Sex concentrating oxy-sinter (amino-based polysulfide, argon-modified amp; uf poly-polyoxyalkylene, alkyl-modified polyoxyalkylene, fluorine-modified polyoxyalkylene, etc.). As a water-soluble polymer, it can be listed as: carrageenan, pectin, ganlu sugar, cardide polysaccharide, sulfur-soft moon, starch, glycogen, gum arabic , 黄蓍麟, 夕二仙胶, sulfuric acid polysaccharide, hydroxyethyl melon 156749.doc 201208712 尔胶it methyl guar, guar gum, dextran, keratin, locust bean gum, amber gluten, carapace , chitosan, carboxymethyl chitin, agar, etc. As a higher alcohol, hexanol, octanol, cetyl alcohol, stearyl alcohol, wax alcohol, behenyl alcohol, triacontanol, Examples of the tertiary fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, and behenic acid. Examples of the pharmaceutical agent include L. ascorbic acid and derivatives thereof. a salt of a salt, a tranexamic acid and a derivative thereof, a salt of an alkoxy salicylic acid and a derivative thereof, a salt of a glutathione peptide and a derivative thereof, and more specifically, as an L_anti-scurvy Derivatives can be exemplified by L-ascorbic acid monostearate, L-ascorbyl monopalmitate, L-resistant L-ascorbic acid monoester such as L-ascorbic acid monoalkyl ester such as acid monooleate, L-ascorbic acid monoester such as l-ascorbic acid _2_sulfate, L-ascorbyl distearate, L-ascorbic acid L-ascorbic acid dialkyl ester such as dipalmitic acid vinegar, L-ascorbic acid dioleate, L_anti-ascorbic Ssl distearate, L-ascorbic acid tri-categoric acid vinegar, L-ascorbic acid dioleate, etc. L-ascorbic acid tris-ester, L-ascorbic acid triester such as L-ascorbic acid triphosphate, L-ascorbic acid glucoside such as L-ascorbic acid 2-glucoside, etc. In the present invention, L-ascorbic acid, L - a form of each of the salts of ascorbyl phosphate, L-ascorbic acid-2-sulfate, and L-ascorbic acid 2-glucoside is preferably used. As the derivative of the derivative acid, a dimer of a tranexamic acid is exemplified. (for example, trans-4-(trans-aminomercaptocyclohexanecarbonyl)aminomethylcyclohexanecarboxylic acid, etc.), an ester of tranexamic acid and hydroquinone (for example, 4- (trans-amino group 156749.doc -13· 201208712 methyl hexane carboxylic acid) 4'-hydroxyphenyl ester, etc., tranexamic acid and gentisic acid a (for example, 2-(trans-4-aminomethylcyclohexylcarbonyloxy)-5-hydroxybenzoic acid, etc.), a guanamine of a tranexamic acid (for example, trans-4-aminomethyl) Cyclohexanecarboxylic acid methyl tyranamine, trans _4·(p-methoxyphenyl fluorenyl) aminomethylcyclohexanone acid, trans-4-mercaptomethylcyclohexanecarboxylic acid, etc. In the present invention, it is preferably used in the form of a salt of a tranexamic acid or a salt of a tranexamic acid derivative. Any one of the 3, 4 or 5 positions of the alkoxy salicylic acid salicylic acid The hydrogen atom is substituted by an alkoxy group, and the alkoxy group as a substituent is preferably a methoxy group, an ethoxy group, a propoxy group, a #propoxy group, a butoxy group or an isobutoxy group. Further preferred is a methoxy group or an ethoxy group. Specific examples of the compound name include .3_T-oxysalicylic acid, 3·ethoxysalicylic acid, methoxymethoxysalicylic acid, 4-ethoxysalicylic acid, and 4-propoxy water. Salicylic acid, 'isopropoxysalicylic acid, 4-butoxysalicylic acid, 5-methoxysalicylic acid, 5-ethoxysalicylic acid, 5-propoxysalicylic acid, and the like. In the present invention, it is preferably used in the form of each salt of alkoxysalicylic acid and its derivatives (esters, etc.). The salt of the above-mentioned agent is not particularly limited. For example, in addition to an alkali metal salt or an alkaline earth metal salt such as a sodium salt, a potassium salt or a calcium salt, a salt such as an ammonium salt or an amino acid salt can be mentioned. In addition, vitamin A, vitamin A palmitate, vitamin A acetate and other vitamin A derivatives, vitamin & hydrochloride, vitamin tripalmitate, vitamin Β octyl citrate, vitamin 匕 and Derivatives, Vitamin I Bu, vitamins and their derivatives, vitamins, tocopherols, tocopherols, vitamins and acetates, vitamins 1), vitamins, pantothenic acid, pantethine And other vitamins; γ-vitamin, allantoin, I56749.doc -14· 201208712 ^酉: (salt) 'glycyrrhetinic acid, licoricetic acid eighteen-burning vinegar, grab wood alcohol, 'also alcohol' Anthraquinone, thymol, inositol, saikosaponin, saponin, saponin, loofah, & + ^ saponin, such as saponin, panthenol ether, bearberry, saponin, etc.; , Sophora flavescens, Pleurotus ostreatus, orange, sage grass, mallow, medicine, thyme, angelica, spruce, birch: thief, loofah, horse chestnut, saxifrage, scutellaria, arnica J is also a plant extract of grass peony, aloe vera, hazelnut, cherry leaf, etc.; . Eight he can list lower alcohols such as ethanol, butyl hydroxytoluene, δ-fertility, non-butyl and other antioxidants, benzoic acid, salicylic acid, sorbic acid, alkyl benzoic acid, phenoxyethanol, A hexa-ol, ε-poly-aminic acid, etc., an organic or inorganic acid such as citric acid, lactic acid or hexaploxate, and a salt thereof. Specific examples of the water-reducing oil-type emulsified skin cosmetic of the present invention include emulsion, moisturizer, hair lotion, liquid foundation, eyeliner, mascara, eye shadow, and the like, or creamy products, but not Limited to these examples. [Examples] The present invention will be specifically described by the following examples, but the present invention is not limited to the examples. Further, as long as the amount of the coating is not particularly marked, the mass is % by mass. ° First, the test method and evaluation method used in the present embodiment will be described. . In the production method, the hydrogenated phospholipid is subjected to a poly-alcohol 117 such as 1,3-butanediol or glycerin at 70 C; and the aqueous phase is prepared by aging. Then, at 7 〇. The oil phase is dissolved in the raw material, and a homomixer is used in the previous water phase. A 156749.doc -15· 201208712 surface is slowly added. After the emulsification is finished, it is cooled to 3 〇〇C for degassing. , Filter 'to get the target sample. (1) Stability test (odor) The odor of the sample after being placed for 5 months under TC was evaluated by functional observation, and evaluated according to the following evaluation criteria. (Evaluation criteria) 〇: No change in taste was observed. I can feel a little bit of odor but within the allowable range. X: I saw the odor and it exceeded the allowable range. (2) The skin roughness improvement effect The testee was a 20 to 50-year-old woman with rough skin and troubles, 30 people in each group. The cream of the example or the comparative example was used for 2 weeks on the face frequency of the face. The skin (4) improvement effect was evaluated according to the tester's own report. The evaluation was based on the evaluation criteria shown below, and the effect was remarkable and effective. It is said to be effective and ineffective at 4 levels, and is represented by a ratio (effectiveness) which is effective and slightly effective. The impression of the surface morphology of the skin is taken and observed by a microscope (Η倍), and according to Table 1 The standard is evaluated on the skin's rough (four) state. <Evaluation criteria> The effect is remarkable: the skin is dry and free, and the smooth touch is obtained. Effective: The skin is less dry and the smooth touch is increased. Effect: The skin is less dry. Invalid: The skin is dry without change, or worse. 156749.doc •16· 201208712 [Table l] The benchmark of the score 1 The groove epidermis, the ridge epidermis disappear, and the extensive stratum corneum is curled 2 The epidermis and ridge epidermis are not clear, the stratum corneum is curled and the sulcus is not visible, but the flat 4 groove epidermis and ridge epidermis are clear. 5 groove epidermis, ridge epidermis is clear and tidy (3) usability (no sticky when used) Sense) <Evaluation Criteria> ◎: The person who answers the non-sticky feeling is 25 or more 〇: The person who answers the non-sticky feeling is 20~24 people △: The person who answers the non-sticky feeling is 15~19 people x: Answer no The person with a sticky feeling is 14 or less [Table 2] Ingredient name Example 1 2 3 4 5 (1) Ion exchange water remaining remaining remaining (2) D-alanine [(A) component] 0.1 3.0 5.0 1.0 0.1 (3) Glycerin [(C) component 1 5.0 10.0 15.0 5.0 10.0 (4) 1,3-butanediol [(C) component] 3.0 3.0 3.0 3.0 3.0 (5) Hydrogenated phospholipid (PC content is 90% or more) * 1[(B) component] 0.1 1.0 3.0 5.0 3.0 (6) Phenoxyethanol 0.5 0.5 0.5 0.5 0.5 (7) Hydrogenated polyisobutylene 5.0 5.0 5.0 5.0 5.0 156 749.doc •17- 201208712 (8)Dicloza 5.0 5.0 5.0 5.0 5.0 (9) Vaseline 2.0 2.0 2.0 2.0 2.0 (10) Cetyl alcohol 2.0 2.0 2.0 2.0 2.0 (11) Glyceryl stearate 2.5 2.5 2.5 2.5 2.5 (12) sorbitan tristearate 0.2 0.2 0.2 0.2 0.2 (13) Myristate myristate 2.0 2.0 2.0 2.0 2.0 (14) Stearyl alcohol 0.2 0.2 0.2 0.2 0.2 (15) Behenyl alcohol 0.3 0.3 0.3 0.3 0.3 (16) Ethylenediaminetetraacetate 0.1 0.1 0.1 0.1 0.1 (17) (Dimercaptopropene decylamine / propylene decyl fluorenyl taurate) crosslinked copolymer 0.3 0.3 0.3 0.3 0.3 (1) Stability (smell) 〇〇〇〇〇 (2) <Skin roughening effect> The effect is remarkable 4 6 6 7 5 Effective 5 8 13 13 5 Slightly effective 12 9 6 6 12 Invalid 9 7 5 4 8 (Rough skin Improve efficiency) 70.0 76.7 83.3 86.7 73.3 <Date score> 1 0 0 0 0 0 2 1 0 0 0 1 3 9 10 6 9 9 4 19 7 15 15 19 5 1 3 9 6 1 (3) Sex (stickiness) ◎ ◎ 〇 ◎ 〇* 1 : Trade name: COATSOMENC-21 (manufactured by Sakamoto Oil Co., Ltd.) 156749.doc -18- 201208712 [Table 3] Comparison of composition names 1 2 3 4 5 (1) Ion exchange water remaining remaining remaining surplus (2) D-alanine [(A) component] - 0.1 0.1 - - (3) Glycerol [(C) component] 5.0 - 10.0 - 15.0 (4 1,3-butanediol [(C) component] 3.0 3.0 3.0 3.0 3.0 (5) Hydrogenated phospholipid (PC content is 90 ° /. Above) Wood 1 [(B) component] 0.1 0.1 - - - (6) Phenoxyethanol 0.5 0.5 0.5 0.5 0.5 (7) Hydrogenated polyisobutylene 5.0 5.0 5.0 5.0 5.0 (8) Isohexadecane 5.0 5.0 5.0 5.0 5.0 (9 Vaseline 2.0 2.0 2.0 2.0 2.0 (10) Cetyl alcohol 2.0 2.0 2.0 2.0 2.0 (11) Glyceryl stearate 2.5 2.5 2.5 2.5 2.5 (12) Sorbitan tristearate 0.2 0.2 0.2 0.2 0.2 ( 13) Myristate myristate 2.0 2.0 2.0 2.0 2.0 (14) Stearyl alcohol 0.2 0.2 0.2 0.2 0.2 (15) Yamazaki alcohol 0.3 0.3 0.3 0.3 0.3 (16) Ethylenediamine tetraacetate 0.1 0.1 0.1 0.1 0.1 (17 ) (Dimethyl acrylamide / propylene decyl sulfonium taurate) crosslinked copolymer 0.3 0.3 0.3 0.3 0.3 (1) Stability (odor) 〇〇0 〇〇 (2) < Skin roughness improvement Effect > Effect is significant 0 0 3 0 1 Valid 3 1 4 0 1 Slightly effective 7 3 5 2 17 Invalid 20 16 18 28 1 (Skin roughening is effective) 33.3 13.3 40.0 6.7 43.3 156749.doc -19- 201208712
<印模評分> 1 0 0 0 0 0 2 10 16 9 11 19 3 13 8 19 15 2 4 7 6 2 4 2 5 0 0 0 0 0 (3)使用性(黏腻感） 〇 ◎ Δ ◎ X 木1 :商品名：COATSOMENC-21(日本油脂股份有限公司製造) [表4] 成分名 實施例 比較例 6 7 8 9 6 7 (1)離子交換水 剩餘 剩餘 剩餘 剩餘 剩餘 剩餘 (2)D-丙胺酸[(A)成分] 0.1 3.0 5.0 1.0 0.1 (3)甘油[(C)成分] 5.0 5.0 5.0 5.0 10.0 5.0 (4)1,3-丁二醇[(C)成分] 3.0 3.0 3.0 3.0 3.0 3.0 (5)氫化磷脂質(PC含量為90°/。以上)* 1【(B) 成分] 1.5 - - 5.0 3.0 0.1 (6)氫化磷脂質(PC含量為60°/。以上)* 2【(B) 成分J - 1.5 - 0.5 - ⑺氫化磷脂質(PC含量為75〜80°/。)* 3[(B)成 分] - - 1.5 1.0 - - (8)氫化磷脂質(PC含量為25-30°/。)* 4 - - - - 1.5 1.5 (9)二棕櫚醯基磷脂酸(酸性磷艏質)木5 0.3 - - - - 0.3 (10)苯氧基乙醇 0.5 0.5 0.5 0.5 0.5 0.5 (11)氫化聚異丁烯 5.0 5.0 5.0 5.0 5.0 5.0 (12)異十六烷 5.0 5.0 5.0 5.0 5.0 5.0 (13)凡士林 2.0 2.0 2.0 2.0 2.0 2.0 (14)十六烷醇 2.0 2.0 2.0 2.0 2.0 2.0 (15)硬脂酸甘油酯 2.5 2.5 2.5 2.5 2.5 2.5 (16)三硬脂酸山梨糖醇酐酯 0.2 0.2 0.2 0.2 0.2 0.2 (17)肉豆蔻酸肉豆蔻酯 2.0 2.0 2.0 2.0 2.0 2.0 -20- 156749.doc 201208712 (18)硬脂醇 0.2 0.2 0.2 0.2 0.2 0.2 (19)山蝓醇 0.3 0.3 0.3 0.3 0.3 0.3 (20)乙二胺四乙酸鹽 0.1 0.1 0.1 0.1 0.1 0.1 (21)(二甲基丙烯醢胺/丙烯醯基二甲基牛磺 酸鈉)交聯共聚物 0.3 0.3 0.3 0.3 0.3 0.3 ⑴穩定性(氣味） 〇 〇 0 0 X X (2)<肌膚粗糙改善效果> 效果顯著 6 4 5 8 0 0 有效 8 5 5 12 1 3 稍稍有效 9 12 12 5 5 7 無效 7 9 8 5 24 20 (肌膚粗糙改善有效率） 76.7 70.0 73.3 83.3 20.0 33.3 <印模評分> 1 0 0 0 0 0 0 2 0 1 1 0 14 15 3 10 9 12 6 13 13 4 17 19 16 15 3 2 5 3 1 1 9 0 0 (3)使用性(黏膩感） ◎ ◎ ◎ ◎ Δ 〇 木1 :商品名：COATSOMENC-2U日本油脂股份有限公司製造） * 2 :商品名：COATSOMENC-61(日本油脂股份有限公司製造） * 3 ··商品名：NIKKOLResinolS-10E(Nikko Chemicals股份有限公司製造） * 4 :商品名：NIKKOLResinolS-10(NikkoChemicals股份有限公司製造） 木5 :商品名：MA-6060(日本油脂股份有限公司製造） 根據表2〜4很清楚，含有作為本發明之必需成分之成分 (A) D-胺基酸、其衍生物及/或其鹽之1種或2種以上、成分 (B) 磷脂醯膽鹼之含量為50質量％以上之氫化磷脂質之1種 或2種以上、及成分（C)水溶性多元醇之本發明的實施例 1〜9係肌膚粗糙改善用皮膚化妝品，其使用性優異且改善 肌膚粗糙，尤其是角質之粗糙化、乾燥，調整肌膚紋理， 實現光滑之肌膚，又，安全性、穩定性及觸感方面亦優 •21 · 156749.doc 201208712 異。然而，缺少本發明之必需成分之比較例1〜7缺少上述 肌膚改善效果及優異使用性之任一者。 以下’進而例示本發明之其他實施例。 再者，亦對以下之實施例進行與上述相同之效果試驗， 結果均獲得優異結果。 實施例10 :潤膚霜（0/W型（Oil in water，水中油型）） 成分 調配量 (質量°/。） (1)硬脂醇 2.0 (2)山蓊醇 1.0 (3)氫化聚異丁烯 4.0 (4)角鯊烧 7.0 (5)二新戊酸三丙二醇 2.0 (6)成分（C)甘油 5.0 (7)成分（C)二丙二醇 3.0 (8)成分（B)氫化磷脂質（PC含量60%以 上） 2.0 (商品名：COATSOME NC-61，日 製造） 本油脂股份有限公司 (9)成分（C)聚乙二醇1500 1 Π (10)單椰子油脂肪酸聚氧乙烯（20)山梨糖醇針 3 〇 (商品名：NIKK〇L TL-10V，Nikk0 Chemicals股份0有限 公司製造） (11)單硬脂酸甘油酯 2.0 156749.doc -22- 201208712 (12)對羥苯甲酸乙酯 0.1 (13)對羥苯甲酸丁酯 0.1 (14)生育酚 0.1 (15)成分（A)D-丙胺酸 2.0 (16)香料 適量 (17)離子交換水 剩餘 <製法> 將（8)、（9)、（12)〜（15)加溫至7(TC並使其溶解於（6)、（7) 中。繼而，於（17)中添加先前之混合物調製水相。另一方 面，於70。(：下均勻地加熱溶解（1)〜（5)、（10)、（11)、（16)調 製油相。於70°C之水相中添加70°C之油相，並利用均質攪 拌機均勻地使乳化粒子均勻，進行脫氣、冷卻、過濾，獲 得目標之潤膚霜（0/W型）。 實施例11 :乳液 成分 調配量 (質量％) (1) 一甲聚石夕氧烧5cs 3.0 (2)成分（B)氫化磷脂質（pc含量95%以上） 1.0 (商品名：NIKKOL S-10EX，Nikko Chemicals股份有 | 公司製造） (3)角鯊烷 2.0 (4)烯烴寡聚物 1.0 (5)異壬酸異十三烷基酯 2.0 156749.doc -23- 201208712 (6)硬脂酸PEG-20 0.3 (商品名：EMALEX 820，Nihon 製造） Emulsion股份有限公司 (7)倍半硬脂酸山梨糖醇酐 0.1 (商品名.NIKKOL SS-15V，Nikko Chemicals股份有限 公司製造） (8)單硬脂酸甘油酯（自己乳化型） 0.3 (商品名：NIKKOL MGS-ASEV 有限公司製造） ，Nikko Chemicals股份 (9)香料 適量 (10)成分（C)二丙二醇 1.0 (Π)成分（C)l，3-丁二醇 4.0 (12)成分（C)甘油 8.0 (13)羧乙烯聚合物 0.1 (14)烷基改性羧乙烯聚合物 0.05 (15)氫氧化鉀 適量 (16)成分（A)D-甲硫胺酸 3.5 (17)木賊萃取物 0.1 (18)金縷梅萃取物 0.1 (19)乙醇 5.0 (20)苯氧基乙醇 0.3 (21)離子交換水 剩餘 156749.doc •24 201208712 <製法> 將（2)、（20)加溫至70。(：並使其溶解於（ι〇)〜（12)中。繼 而’於（21)中添加先前之混合物及添加（13)〜（19)，調製水 . 相。另一方面’使（1)、（3)〜(8)、（9)於70°C下均勻地溶解 調製油相。於70°C之水相中添加70。(：之油相，並利用均質 攪拌機均勻地使乳化粒子均勻，進行脫氣、冷卻、過渡， 獲得目標之乳液。 實施例12 :潤膚霜（0/W型） 成分調配量（質量％) (1) 山荼醇 0.1 (2) 鯊肝醇 〇_5 (3) 氫化聚異丁烯 4.〇 (4) 液態石蠟 5.0 (5) 乙基己酸十六烧基酯 1.0 (6) 十曱基環戊矽氧烷 15.0 (7) 成分（B)氫化磷脂質（PC含量90%) 0.5 (商品名：COATSOME NC-21，日本油脂股份有限公司 製造） (8) 成分（B)氫化磷脂質（磷脂酸：PA100%) 0.5 (商品名：COATSOME MA-6060LS，日本油脂股份有限 公司製造） (9) 香料 0·1 (10) 成分（C)聚乙二醇 20000 1.0 156749.doc -25- 201208712 (11)對羥苯甲酸乙酯 0.1 (12)對羥苯甲酸丁酯 0.1 (13)生育酚 0.1 (14)(二甲基丙烯醯胺/2-丙烯醯胺-2-甲基丙磺 酸）共聚物 0.2 (15)成分（A)D-半胱胺酸 2.0 (16)山楂萃取物 0.1 (17)蒲桃葉萃取物 0.1 (18)蘆薈萃取物 0.1 (19)地榆萃取物 0.1 (20)丁香萃取物 0.1 (21)魚腥草萃取物 0.1 (22)蜀葵根萃取物 0.1 (23)紫草根萃取物 0.1 (24)成分（C)l，3-丁二醇 3.0 (25)成分（C)甘油 9.0 (26)離子交換水 剩餘 <製法> 將（7)、（8)、（10)〜(23)加溫至70°C並使其溶解於（24)、 (25)中。繼而，於（26)中添加先前之混合物調製水相。另 一方面’於70°C下均勻地加熱溶解（1)〜（6)、（9)調製油相。 於70°C之水相中添加7(TC之油相，並利用均質搜掉機均勺 地使乳化粒子均勻，進行脫氣、冷卻、過濾，獲得目押之 156749.doc -26 - 201208712 潤膚霜（o/w型）。 實施例13 :潤膚霜（W/O型（Water in Oil，油中水型）) 成分 調配量 (質量％) (1)微晶蠟 2.0 (2)液態石蠟 25.0 (3)氫化菜籽種子油 5.0 (4)二油酸聚甘油-2 5.0 (商品名：NIKKOL DGDO，Nikko Chemicals股份有限公 司製造） (5)對羥苯曱酸丁酯 0.1 (6)香料 0.1 (7)成分（B)氫化磷脂質（PC含量90%) 2.5 (商品名· C 0 AT SOME NC-21，日本油脂股份有限公司 製造） (8)榖胺酸鈉 1.6 (9)離子交換水 剩餘 (10)成分（C)丙二醇 3.0 (11)成分（C)甘油 7.0 (12)成分（A)D-脯胺酸 4.5 (13)洋甘菊萃取物 0.1 (14)苦參萃取物 0.1 156749.doc -27- 201208712 <製法> 將一部分及（4) 〜六巧司（胺基酸凝 膠）。繼而，以分散機使先前之胺基酸凝膠均勻地分散於 使（1)〜（3)之油相於70°C下溶解者中。 (7)於70°C下加熱並使其溶解於（10)、 另—方面，將（5)、 (11)中’與將剩餘之 將該水相 (9)、（12)〜（14)於70°C下加熱者混合，調製水相 於先前之分散液中一面充分攪拌一面添加，並以分散機使 其均勻地乳化後，添加（6)並以分散機使其均勻地分散。進 行脫氣、冷卻、過濾，獲得目標之潤膚霜（w/〇型）。 實施例14:具有抗老化.美白效果之综合霜⑴型） 成分 調配量 (質量％) (1)棕櫊酸 2.0 (2)十六醇 1.5 (3)凡士林 3.0 (4)角鯊烷 5.0 (5)三乙基己醇 2.0 (6)油酸山梨糖醇酐 2.0 (商品名：EMALEX SPO-100，Nihon Emulsion股份有限 公司製造） (7) 香料 0.1 (8) 成分（B)氫化磷脂質（PC含量75〜85%) 0.8 (商品名：NIKKOL S-10EX，Nikko Chemicals股份有限 156749.doc -28 - 201208712 公司製造） (9)傳明酸 2.0 (1〇)(丙烯醯基二曱基牛磺酸銨/乙烯基》比咯烷 0.1 酮）共聚物 (11)對羥苯甲酸甲酯 0.1 (12)苯氧基乙醇 0.1 (13)成分（C)甘油 13.0 (14)成分（C)l，3-丁二醇 3.0 (15)弟切草萃取物 0.1 (16)兒茶萃取物 0.1 (17)草木犀萃取物 0.1 (18)成分（A)D-絲胺酸 1.5 (19)離子交換水 剩餘 <製法> 將⑻加溫至70。(：並使其溶解於（13)、（Η)中。 繼而，於 (19)中添加先前之混合物及（9)、（1〇)、（^) 、（12)、 (15) (I8)凋製水相。另一方面，將（丨）~(7)加熱至7〇〇c調製 油相。於70t之水相中添加7(TC之油相，並以均質攪拌機 均勻地使乳化粒子均勻，進行脫氣、冷卻、過減 ，獲得目 標之具有抗老化.美白效果之综合霜（0/W型）。 156749.doc ·29· 201208712 實施例15 ··潤膚霜（W/〇型） 成分 調配量· (1)角鯊烷 (質量％) (2)乙基己酸十六燒基酯 15.〇 (3)異壬酸異壬酯 5.0 (4)微晶蠟 3.5 (5)二硬脂基二，基銨鋰蒙脫石 1.0 (6)PEG-10二f聚矽氧烷 1.5 (商品名：KF-6017，冑越化學工業股份有限公 1.0 司製造） (7)十甲基環戊矽氧烷 A (8)成分（B)氫化磷脂質（Pc含量9〇〇/0) 5.0 1.5 (商品名：COATSOME NC-21，日本油脂股份有限公司 製造） (9)香料 0.1 (1〇)成分（0：)1，3-丁二醇 5.0 (11)成分（C)甘油 5.0 (12)成分（A)D-榖胺酸 2.0 (13)對羥苯甲酸乙酯 0.1 (14)苯氧基乙醇 0.2 (15)抗壞血酸麟酸鎮 0.1 (16)野生百里香萃取物 0.1 (1 7)茶葉萃取物 0.1 (1 8)離子交換水 剩餘 156749.doc -30- 201208712 <製法> 將⑴〜⑺、（9)調製為贼，並使其均勻 獲得油性凝膠。另一女&收/〇、 狀/合解 ⑽、⑴Μ Ο加溫至7Gt並使其溶解於 鰱而，於（18)中添加（12)與先前之、 ⑽、⑴）之混合物、及（13)〜(17)調製水相。將該水相向 先前調製之油性凝膠中一面充分地授拌一面緩緩添加。以 分散機均旬地調製乳化粒子後，進行脫氣、冷卻、過渡， 獲得目標之潤膚霜（W/〇型）。 實施例16 :凝膠狀美容液 成分 調配量 (質量。/。) (1) 聚丙烯酸鈉/2-丙烯醯胺-2-曱基丙磺酸共聚物 2 〇 (商品名：COATSOME NC-61，日本油脂股份有限公司 (2) 成分（B)氫化磷脂質（pc含量60%以上） 2 〇 製造） (3)二甲聚矽氧烷5cs 5.0 (4)P〇E(20)山蓊醚 0.5 (商品名：NIKKOL B-20，Nikko Chemicals股份有限公 司製造） (5)乙醇 5.0 (6)苯氧基乙醇 0.1 (7)香料 0.1 (8)離子交換水 剩餘 156749.doc -31- 201208712 (9)成分（C)甘油 6.0 (10)成分（C)l，3-丁二醇 3.0 (11)梔子萃取物 0.1 (12)當歸根萃取物 0.1 (13)七葉樹萃取物 0.1 (14)生薑萃取物 0.1 (15)牡丹萃取物 0.1 (16)成分（A)D-丙胺酸 0.3 <製法> 將（2)加溫至70°C並使其溶解於（9)、（10)中。繼而，於 (8)中添加先前之混合物及（1)、（5)、（6)、（11)〜（16)調製水 相。另一方面，將（3)、（4)、（7)混合調製油相。於水相中 添加油相，並以分散機使其均勻地分散。進行脫氣、冷 卻、過濾，獲得目標之凝膠狀美容液。 156749.doc -32-<Date score> 1 0 0 0 0 0 2 10 16 9 11 19 3 13 8 19 15 2 4 7 6 2 4 2 5 0 0 0 0 0 (3) Usability (stickiness) 〇◎ Δ ◎ X Wood 1 : Trade name: COATSOMENC-21 (manufactured by Nippon Oil & Fat Co., Ltd.) [Table 4] Component name Example Comparative Example 6 7 8 9 6 7 (1) Ion exchange water remaining remaining remaining remaining (2) D-alanine [(A) component] 0.1 3.0 5.0 1.0 0.1 (3) Glycerol [(C) component] 5.0 5.0 5.0 5.0 10.0 5.0 (4) 1,3-butanediol [(C) component] 3.0 3.0 3.0 3.0 3.0 3.0 (5) Hydrogenated phospholipids (PC content of 90 ° /. or more) * 1 [(B) Ingredients 1.5 - - 5.0 3.0 0.1 (6) Hydrogenated phospholipids (PC content is 60 ° /. or more) * 2 [(B) Component J - 1.5 - 0.5 - (7) Hydrogenated phospholipid (PC content is 75~80 ° /.) * 3 [(B) component] - - 1.5 1.0 - - (8) Hydrogenated phospholipid (PC content 25-30°/.)* 4 - - - - 1.5 1.5 (9) Dipalmitoylphosphatidic acid (acidic phosphonium) wood 5 0.3 - - - - 0.3 (10) Phenoxyethanol 0.5 0.5 0.5 0.5 0.5 0.5 (11) hydrogenated polyisobutylene 5.0 5.0 5.0 5.0 5.0 5.0 (12) isohexadecane 5.0 5.0 5.0 5.0 5.0 5.0 (13) Vaseline 2.0 2.0 2 .0 2.0 2.0 2.0 (14) Cetyl alcohol 2.0 2.0 2.0 2.0 2.0 2.0 (15) Glyceryl stearate 2.5 2.5 2.5 2.5 2.5 2.5 (16) Sorbitan tristearate 0.2 0.2 0.2 0.2 0.2 0.2 (17) Myristate myristate 2.0 2.0 2.0 2.0 2.0 2.0 -20- 156749.doc 201208712 (18) Stearyl alcohol 0.2 0.2 0.2 0.2 0.2 0.2 (19) Behenyl alcohol 0.3 0.3 0.3 0.3 0.3 0.3 (20) B Diamine tetraacetate 0.1 0.1 0.1 0.1 0.1 0.1 (21) (Dimethyl acrylamide / sodium propylene dimethyl dimethyl sulfonate) crosslinked copolymer 0.3 0.3 0.3 0.3 0.3 0.3 (1) Stability (odor) 〇 〇0 0 XX (2)<skin roughening effect> The effect is remarkable 6 4 5 8 0 0 Effective 8 5 5 12 1 3 Slightly effective 9 12 12 5 5 7 Invalid 7 9 8 5 24 20 (The skin roughness is improved Efficiency) 76.7 70.0 73.3 83.3 20.0 33.3 <Date score> 1 0 0 0 0 0 0 2 0 1 1 0 14 15 3 10 9 12 6 13 13 4 17 19 16 15 3 2 5 3 1 1 9 0 0 (3) Usability (adhesiveness) ◎ ◎ ◎ ◎ Δ 〇木1 : Trade name: COATSOMENC-2U manufactured by Nippon Oil & Fat Co., Ltd.) * 2 : Trade name: COATSOMENC-61 (Japanese oil stocks) Co., Ltd.) * 3 ··Medical name: NIKKOLResinolS-10E (manufactured by Nikko Chemicals Co., Ltd.) * 4 : Trade name: NIKKOL ResinolS-10 (manufactured by Nikko Chemicals Co., Ltd.) Wood 5 : Trade name: MA-6060 (Japanese fat (manufactured by the company of the company) It is clear that the component (A) which is an essential component of the present invention contains one or more kinds of D-amino acids, derivatives thereof and/or salts thereof, and components (B) The skin cosmetics for skin roughness improvement of Examples 1 to 9 of the present invention in which one or two or more kinds of hydrogenated phospholipids having a phospholipid choline content of 50% by mass or more and a component (C) of a water-soluble polyol are contained, It is excellent in use and improves skin roughness, especially roughening and drying of keratin, adjusting skin texture to achieve smooth skin, and also excellent in safety, stability and touch. 21 · 156749.doc 201208712 However, Comparative Examples 1 to 7 which lacked the essential components of the present invention lack any of the above-mentioned skin improving effects and excellent usability. The following 'further exemplifies other embodiments of the present invention. Further, the same effects as those described above were also carried out on the following examples, and as a result, excellent results were obtained. Example 10: Moisturizer (0/W type (Oil in water)) Composition amount (mass ° /.) (1) Stearyl alcohol 2.0 (2) Kaempferol 1.0 (3) Hydrogenation polymerization Isobutylene 4.0 (4) Squalene burning 7.0 (5) Dipropylene glycol dipropylene glycol 2.0 (6) Ingredients (C) Glycerol 5.0 (7) Ingredients (C) Dipropylene glycol 3.0 (8) Ingredients (B) Hydrogenated phospholipids (PC) Contents of 60% or more) 2.0 (trade name: COATSOME NC-61, manufactured in Japan) Oils and Fats Co., Ltd. (9) Ingredients (C) Polyethylene glycol 1500 1 Π (10) Single coconut oil fatty acid polyoxyethylene (20) Sorbitol needle 3 〇 (trade name: NIKK〇L TL-10V, manufactured by Nikk0 Chemicals, Inc.) (11) glyceryl monostearate 2.0 156749.doc -22- 201208712 (12) Hydroxybenzoic acid Ester 0.1 (13) butyl paraben 0.1 (14) Tocopherol 0.1 (15) Ingredients (A) D-alanine 2.0 (16) Perfume amount (17) Ion exchange water remaining <Preparation method> ), (9), (12) to (15) are heated to 7 (TC and dissolved in (6), (7). Then, the previous mixture is added to the (17) to prepare the aqueous phase. Aspect, at 70. (: under uniform The oil phase is prepared by heating and dissolving (1) to (5), (10), (11), and (16). An oil phase of 70 ° C is added to the aqueous phase at 70 ° C, and the emulsified particles are uniformly dispersed by a homomixer. Uniform, degassing, cooling, and filtration to obtain the target moisturizer (0/W type). Example 11: Emulsion composition (% by mass) (1) One polymethyst 5cs 3.0 (2) Component (B) Hydrogenated phospholipid (pc content: 95% or more) 1.0 (trade name: NIKKOL S-10EX, manufactured by Nikko Chemicals Co., Ltd.) (3) Squalane 2.0 (4) Olefin oligomer 1.0 (5) Isotridecyl isononanoate 2.0 156749.doc -23- 201208712 (6) Stearic acid PEG-20 0.3 (trade name: EMALEX 820, manufactured by Nihon) Emulsion Co., Ltd. (7) sesquiterpuccinate Sugar Alcohol 0.1 (trade name: NIKKOL SS-15V, manufactured by Nikko Chemicals Co., Ltd.) (8) Glyceryl monostearate (self-emulsified type) 0.3 (trade name: manufactured by NIKKOL MGS-ASEV Co., Ltd.), Nikko Chemicals Shares (9) Proper amount of spices (10) Ingredients (C) Dipropylene glycol 1.0 (Π) Ingredients (C) 1,3-butanediol 4.0 (12) Ingredients (C) Oil 8.0 (13) Carboxyrene polymer 0.1 (14) Alkyl modified carboxyvinyl polymer 0.05 (15) Potassium hydroxide amount (16) Ingredients (A) D-methionine 3.5 (17) Equisetum extract 0.1 (18) Witch hazel extract 0.1 (19) Ethanol 5.0 (20) Phenoxyethanol 0.3 (21) Ion exchange water remaining 156749.doc •24 201208712 <Preparation method> (2), (20) To 70. (: and dissolve it in (ι〇)~(12). Then add the previous mixture in (21) and add (13)~(19) to prepare the water phase. On the other hand, 'make (1) ), (3) to (8), (9) uniformly dissolve the prepared oil phase at 70 ° C. Add 70 to the aqueous phase at 70 ° C. (: the oil phase, and uniformly emulsified by a homomixer The particles were uniform, degassed, cooled, and transitioned to obtain the target emulsion. Example 12: Moisturizer (0/W type) Ingredient amount (% by mass) (1) Kaempferol 0.1 (2) Shark liver alcohol _5 (3) hydrogenated polyisobutylene 4. 〇 (4) liquid paraffin 5.0 (5) hexadecyl ethyl hexanoate 1.0 (6) decamethylcyclopentanoxane 15.0 (7) component (B) hydrogenation Phospholipid (PC content 90%) 0.5 (trade name: COATSOME NC-21, manufactured by Nippon Oil & Fat Co., Ltd.) (8) Ingredient (B) Hydrogenated phospholipid (phosphatidic acid: PA100%) 0.5 (trade name: COATSOME MA- 6060LS, manufactured by Nippon Oil & Fat Co., Ltd.) (9) Perfume 0·1 (10) Ingredient (C) Polyethylene Glycol 20000 1.0 156749.doc -25- 201208712 (11) Ethyl p-hydroxybenzoate 0.1 (12) Butyl hydroxybenzoate 0.1 (13) Tocopherol 0.1 (14) (Dimethyl acrylamide / 2-propenylamine-2-methylpropane sulfonic acid) copolymer 0.2 (15) Ingredients (A) D-cysteine 2.0 ( 16) Hawthorn Extract 0.1 (17) Rose Apple Leaf Extract 0.1 (18) Aloe Vera Extract 0.1 (19) Cellar Extract 0.1 (20) Clove Extract 0.1 (21) Houttuynia Extract 0.1 (22) Hollyhock Root Extract 0.1 (23) Lithospermum Root Extract 0.1 (24) Ingredients (C) 1,3-Butanediol 3.0 (25) Ingredient (C) Glycerin 9.0 (26) Ion Exchange Water Residual <Manufacturing Method> , (8), (10) to (23) are heated to 70 ° C and dissolved in (24), (25). Then, the previous mixture is added to the (26) to prepare the aqueous phase. In the aspect of 'heating and dissolving (1) ~ (6), (9) to prepare the oil phase uniformly at 70 ° C. Add 7 (the oil phase of TC) in the aqueous phase at 70 ° C, and use the homogenizer to scoop the scoop The emulsified particles were uniformly dispersed, degassed, cooled, and filtered to obtain a 156749.doc -26 - 201208712 moisturizer (o/w type). Example 13: moisturizer (W/O type (Water in Oil, water type in oil)) Ingredients (% by mass) (1) Microcrystalline wax 2.0 (2) Liquid paraffin 25.0 (3) Hydrogenated rapeseed seed oil 5.0 (4) Dioleic acid polyglycerol-2 5.0 (trade name: NIKKOL DGDO, manufactured by Nikko Chemicals Co., Ltd.) (5) Butyl p-hydroxybenzoate 0.1 (6) Perfume 0.1 (7) Ingredients (B) Hydrogenated phospholipids (PC content 90%) 2.5 (trade name · C 0 AT SOME NC-21, manufactured by Nippon Oil & Fat Co., Ltd.) (8) Sodium citrate 1.6 (9) Ion exchange water remaining (10) component (C) propylene glycol 3.0 (11) component (C) glycerol 7.0 (12) component (A) D-proline acid 4.5 (13) chamomile extract 0.1 (14) Sophora flavescens Extract 0.1 156749.doc -27- 201208712 <Manufacturing Method> A portion and (4) ~ hexazone (amino acid gel). Then, the previous amino acid gel was uniformly dispersed by a dispersing machine to dissolve the oil phase of (1) to (3) at 70 °C. (7) heating at 70 ° C and dissolving it in (10), on the other hand, in (5), (11) 'with the remaining water phase (9), (12) ~ (14 The mixture was heated at 70 ° C, and the aqueous phase was added to the previous dispersion while being sufficiently stirred, and uniformly emulsified by a disperser, and then (6) was added and uniformly dispersed by a disperser. Degas, cool, and filter to obtain the target moisturizer (w/〇 type). Example 14: Comprehensive cream with anti-aging and whitening effect (1) type Ingredients (% by mass) (1) Palmitic acid 2.0 (2) Cetyl alcohol 1.5 (3) Vaseline 3.0 (4) Squalane 5.0 ( 5) Triethylhexanol 2.0 (6) Oleic acid sorbitan 2.0 (trade name: EMALEX SPO-100, manufactured by Nihon Emulsion Co., Ltd.) (7) Perfume 0.1 (8) Ingredient (B) Hydrogenated phospholipid ( PC content 75~85%) 0.8 (trade name: NIKKOL S-10EX, Nikko Chemicals Co., Ltd. 156749.doc -28 - 201208712 company made) (9) tranexamic acid 2.0 (1〇) (acryloyl fluorenyl diphenyl cow Ammonium sulfonate/vinyl"pyrrolidine 0.1 ketone)copolymer (11)methyl p-hydroxybenzoate 0.1 (12) phenoxyethanol 0.1 (13) component (C) glycerin 13.0 (14) component (C) l , 3-butanediol 3.0 (15) Digestive extract 0.1 (16) catechu extract 0.1 (17) Herb Rhizome extract 0.1 (18) Ingredients (A) D-serine 1.5 (19) Ion exchange water remaining <Production Method> (8) was heated to 70. (: and dissolve it in (13), (Η). Then, add the previous mixture in (19) and (9), (1〇), (^), (12), (15) (I8 The aqueous phase is withdrawn. On the other hand, (丨)~(7) is heated to 7〇〇c to prepare the oil phase. 7 (the oil phase of TC is added to the aqueous phase of 70t, and the emulsion is uniformly emulsified by a homomixer) The particles are uniform, degassed, cooled, and reduced, and the target has an anti-aging and whitening effect cream (0/W type). 156749.doc ·29· 201208712 Example 15 ··Moisturizer (W/〇 Type) Composition amount · (1) Squalane (% by mass) (2) Hexyl hexyl hexanoate 15. 〇 (3) Isodecyl isodecanoate 5.0 (4) Microcrystalline wax 3.5 (5 ) distearyl di-, quaternary ammonium hectorite 1.0 (6) PEG-10 di-f-a polyoxyl hydride 1.5 (trade name: KF-6017, manufactured by Min Yue Chemical Industry Co., Ltd.) (7) Methylcyclopentaoxane A (8) component (B) Hydrogenated phospholipid (Pc content 9 〇〇 / 0) 5.0 1.5 (trade name: COATSOME NC-21, manufactured by Nippon Oil & Fat Co., Ltd.) (9) Spice 0.1 (1〇) Ingredients (0:) 1,3-butanediol 5.0 (11) Minutes (C) Glycerin 5.0 (12) Ingredients (A) D-Proline Acid 2.0 (13) Ethyl p-hydroxybenzoate 0.1 (14) Phenoxyethanol 0.2 (15) Ascorbate 0.1 (16) Wild Thyme Extract 0.1 (1 7) Tea extract 0.1 (1 8) Ion exchange water remaining 156749.doc -30- 201208712 <Preparation method> (1)~(7), (9) are prepared into thieves and uniformly obtained oily condensation Glue. Another female & 收, 状/合解(10), (1) Ο Ο warmed to 7Gt and dissolved in 鲢, and added (12) to the mixture of (12) and the previous, (10), (1)) And (13) to (17) to prepare an aqueous phase. The aqueous phase is gradually added to the previously prepared oily gel while being sufficiently mixed. The emulsified particles are uniformly prepared by a dispersing machine, and then degassed and cooled. , transition, to obtain the target moisturizer (W / 〇 type). Example 16: gelatinous cosmetic liquid ingredients (mass. / ()) (1) sodium polyacrylate / 2 - acrylamide - oxime Propanesulfonic acid copolymer 2 〇 (trade name: COATSOME NC-61, Nippon Oil & Fat Co., Ltd. (2) Ingredient (B) Hydrogenated phospholipid (pc content: 60% or more) 2 〇 Manufacture (3) Dimethyl methoxane 5cs 5.0 (4) P〇E (20) Hawthorn Ether 0.5 (trade name: NIKKOL B-20, manufactured by Nikko Chemicals Co., Ltd.) (5) Ethanol 5.0 (6) Benzene Oxyethanol 0.1 (7) Perfume 0.1 (8) Ion exchange water remaining 156749.doc -31- 201208712 (9) Ingredients (C) Glycerol 6.0 (10) Ingredients (C) 1,3-butanediol 3.0 (11) Hazelnut Extract 0.1 (12) Angelica Root Extract 0.1 (13) Horse Chestnut Extract 0.1 (14) Ginger Extract 0.1 (15) Peony Extract 0.1 (16) Ingredients (A) D-Alanine 0.3 < ;Preparation method> (2) was heated to 70 ° C and dissolved in (9), (10). Then, the previous mixture and the aqueous phases (1), (5), (6), (11) to (16) were prepared in (8). On the other hand, (3), (4), and (7) are mixed to prepare an oil phase. The oil phase was added to the aqueous phase and uniformly dispersed by a disperser. Degassing, cooling, and filtration are carried out to obtain a gelatinous cosmetic liquid of the target. 156749.doc -32-