TW200512293A - Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics - Google Patents

Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics

Info

Publication number
TW200512293A
TW200512293A TW093116334A TW93116334A TW200512293A TW 200512293 A TW200512293 A TW 200512293A TW 093116334 A TW093116334 A TW 093116334A TW 93116334 A TW93116334 A TW 93116334A TW 200512293 A TW200512293 A TW 200512293A
Authority
TW
Taiwan
Prior art keywords
eif
apoptosis
sirnas
specific
inhibition
Prior art date
Application number
TW093116334A
Other languages
Chinese (zh)
Inventor
John E Thompson
Catherine Taylor
Original Assignee
Senesco Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senesco Technologies Inc filed Critical Senesco Technologies Inc
Publication of TW200512293A publication Critical patent/TW200512293A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5Al, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
TW093116334A 2003-06-06 2004-06-07 Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics TW200512293A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US47619403P 2003-06-06 2003-06-06
US50473103P 2003-09-22 2003-09-22
US52824903P 2003-12-10 2003-12-10
US55767104P 2004-03-31 2004-03-31
US57581404P 2004-06-02 2004-06-02

Publications (1)

Publication Number Publication Date
TW200512293A true TW200512293A (en) 2005-04-01

Family

ID=34084831

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093116334A TW200512293A (en) 2003-06-06 2004-06-07 Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics

Country Status (9)

Country Link
EP (1) EP1636364A2 (en)
JP (1) JP5666074B2 (en)
KR (1) KR20060013428A (en)
AU (1) AU2004258070B2 (en)
CA (1) CA2528372A1 (en)
IL (1) IL172365A0 (en)
NZ (2) NZ574973A (en)
TW (1) TW200512293A (en)
WO (1) WO2005007853A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381708B2 (en) 2001-07-23 2008-06-03 Sensco Technologies, Inc. Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
WO2004078940A2 (en) 2003-03-05 2004-09-16 Senesco Technologies, Inc. USE OF ANTISENSE OLIGONUCLEOTIDES OR siRNA TO SUPPRESS EXPRESSION OF eIF-5A1
GB0312148D0 (en) 2003-05-28 2003-07-02 Aventis Pharma Ltd Stabilized pharmaceutical products
US20140371299A1 (en) * 2004-06-07 2014-12-18 Senesco Technologies, Inc. Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis
WO2006014752A2 (en) * 2004-07-20 2006-02-09 Senesco Technologies, Inc. Use of apoptosis-specific eif-5a sirnas and antisense polynucleotides to inhibit/suppress an inflammatory response
WO2006060823A2 (en) * 2004-12-03 2006-06-08 Senesco Technologies, Inc. Apoptosis-specific eif-5a and polynucleotides encoding same
US20070154457A1 (en) * 2005-12-13 2007-07-05 Senesco Technologies, Inc. Use of eIF-5A to kill multiple myeloma cells
WO2007109677A2 (en) * 2006-03-20 2007-09-27 Senesco Technologies, Inc. A novel method of protecting islet cells from apoptosis during the donor harvesting process
CA2634814A1 (en) * 2006-03-20 2007-09-27 Senesco Technologies, Inc. Use of apoptosis-specific eif-5a sirna to down regulate expression of proinflammatory cytokines to treat sepsis
KR20080082688A (en) * 2006-03-20 2008-09-11 세네스코 테크놀로지스 인코포레이티드 A novel method of protecting islet cells from apoptosis during the donor harvesting process
WO2007115047A2 (en) * 2006-03-29 2007-10-11 Senesco Technologies, Inc. Inhibition of hiv replication and expression of p24 with eif-5a
CA2700463A1 (en) * 2007-08-20 2009-02-26 Senesco Technologies, Inc. Use of eif-5a1 sirna to protect islets cells from apoptosis and to preserve their functionality
US8703929B2 (en) 2008-03-07 2014-04-22 Senesco Technologies, Inc. Compositions comprising siRNA and plasmids
WO2009144933A1 (en) 2008-05-27 2009-12-03 国立大学法人東京大学 Apoptosis inducer
US8445638B2 (en) 2008-09-03 2013-05-21 Senesco Technologies, Inc. Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ255397A3 (en) * 1995-02-13 1998-02-18 Novartis Ag Mutagenic proteins, process of their preparation, pharmaceutical preparations containing thereof and their use
AU2002344237B8 (en) * 2001-05-29 2008-11-06 Sirna Therapeutics, Inc. Nucleic Acid Based Modulation of Female Reproductive Diseases and Conditions
US7381708B2 (en) * 2001-07-23 2008-06-03 Sensco Technologies, Inc. Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
DK2280070T3 (en) * 2001-07-23 2015-08-24 Univ Leland Stanford Junior Methods and compositions for use in RNAi-mediated inhibition of gene expression in mammals
US7968523B2 (en) * 2001-07-23 2011-06-28 Senesco Technologies, Inc. Method for inducing apoptosis using apoptosis-specific EIF5-A
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
WO2004078940A2 (en) * 2003-03-05 2004-09-16 Senesco Technologies, Inc. USE OF ANTISENSE OLIGONUCLEOTIDES OR siRNA TO SUPPRESS EXPRESSION OF eIF-5A1

Also Published As

Publication number Publication date
JP2006526989A (en) 2006-11-30
JP5666074B2 (en) 2015-02-12
AU2004258070B2 (en) 2008-12-11
NZ574973A (en) 2010-10-29
AU2004258070A1 (en) 2005-01-27
KR20060013428A (en) 2006-02-09
NZ544159A (en) 2009-04-30
WO2005007853A2 (en) 2005-01-27
WO2005007853A3 (en) 2005-10-27
CA2528372A1 (en) 2005-01-27
IL172365A0 (en) 2006-04-10
EP1636364A2 (en) 2006-03-22

Similar Documents

Publication Publication Date Title
WO2004078940A3 (en) USE OF ANTISENSE OLIGONUCLEOTIDES OR siRNA TO SUPPRESS EXPRESSION OF eIF-5A1
TW200512293A (en) Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics
DK1230375T3 (en) Inhibition of gene expression by dsRNA
WO2003012052A3 (en) Specific inhibition of gene expression by small double stranded rnas
EP2527444A3 (en) Antisense oligonucleotide modulation of stat3 expression
EP1537227A4 (en) Method for efficient rna interference in mammalian cells
WO2006119266A3 (en) Human micrornas and methods for inhibiting same
WO2008078180A3 (en) Materials and methods for the generation of transcripts comprising modified nucleotides
DK0731835T3 (en) Antisense oligonucleotides with tumorigenicity inhibiting effect
WO2006047842A3 (en) Modified nucleosides for rna interference
EP1165594A4 (en) Antisense oligonucleotide modulation of stat3 expression
IN2012DN00403A (en)
HU9501963D0 (en) 7-deazapurine modified oligonucleotides
WO2006135436A3 (en) Inhibition of gene expression and therapeutic uses thereof
WO2005118824A3 (en) Methods and compositions for the inhibition of gene expression
TNSN08252A1 (en) Sirna anti myosine va et depigmentation de la peau
EP1509251A4 (en) Nucleic acids, polypeptides, and methods for modulating apoptosis
WO2013040393A3 (en) Genes contributing to survival of cancer cells
WO2003106625A3 (en) Hammerhead ribozymes
TW200615001A (en) Use of apoptosis-specific eIF-5A siRNAs and antisense polynucleotides to inhibit/suppress an inflammatory response
WO2007053207A3 (en) Methods for controlling stem cell differentiation
ATE555201T1 (en) USE OF SIRNA TO ABOLITATE EXPRESSION OF EIF-5A1 IN THE TREATMENT OF GLAUCOMA
WO2007109674A3 (en) Use of eif-5a1 sirna and antisense to treat sepsis or haemorrhagic shock
MD3300G2 (en) Oligonucleotide primer for hepatitis C virus RNA detection
IL156171A0 (en) Dna encoding a plant deoxyhypusine synthase, a plant eukaryotic initiation factor 5a, transgenic plants and a method for controlling senescence programmed and cell death in plants