TW200505923A - Process to beta-ketoamide intermediates to dipeptidyl peptidase inhibitors - Google Patents

Process to beta-ketoamide intermediates to dipeptidyl peptidase inhibitors

Info

Publication number
TW200505923A
TW200505923A TW093107081A TW93107081A TW200505923A TW 200505923 A TW200505923 A TW 200505923A TW 093107081 A TW093107081 A TW 093107081A TW 93107081 A TW93107081 A TW 93107081A TW 200505923 A TW200505923 A TW 200505923A
Authority
TW
Taiwan
Prior art keywords
intermediates
ketoamide
beta
dipeptidyl peptidase
peptidase inhibitors
Prior art date
Application number
TW093107081A
Other languages
Chinese (zh)
Inventor
Norihiro Ikemoto
J Michael Williams
Chun-Hua Yang
Bryon L Simmons
Feng Xu
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of TW200505923A publication Critical patent/TW200505923A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A novel process is provided for the preparation of beta-ketoamide intermediates which are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of type 2 diabetes. Also provided are useful intermediates obtained from the process.
TW093107081A 2003-03-18 2004-03-17 Process to beta-ketoamide intermediates to dipeptidyl peptidase inhibitors TW200505923A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45545803P 2003-03-18 2003-03-18

Publications (1)

Publication Number Publication Date
TW200505923A true TW200505923A (en) 2005-02-16

Family

ID=33030004

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093107081A TW200505923A (en) 2003-03-18 2004-03-17 Process to beta-ketoamide intermediates to dipeptidyl peptidase inhibitors

Country Status (3)

Country Link
AR (1) AR043505A1 (en)
TW (1) TW200505923A (en)
WO (1) WO2004083212A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1794120B1 (en) 2004-07-23 2012-04-11 Nuada, LLC Peptidase inhibitors
CN101374523B (en) 2005-09-14 2012-04-11 武田药品工业株式会社 Dipeptidyl peptidase inhibitors for the treatment of diabetes
US8222411B2 (en) 2005-09-16 2012-07-17 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
EP2726484A1 (en) 2011-06-29 2014-05-07 Ranbaxy Laboratories Limited Solid dispersions of sitagliptin and processes for their preparation
WO2013001457A1 (en) 2011-06-30 2013-01-03 Ranbaxy Laboratories Limited Novel salts of sitagliptin
US20140350023A1 (en) 2011-12-08 2014-11-27 Ranbaxy Laboratories Limited Amorphous form of sitagliptin salts
CN116199691A (en) * 2022-09-01 2023-06-02 淄博矿业集团有限责任公司 Synthesis method of sitagliptin important intermediate
WO2024121301A1 (en) 2022-12-09 2024-06-13 Krka, D.D., Novo Mesto Process for the preparation of sitagliptin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74912C2 (en) * 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes

Also Published As

Publication number Publication date
WO2004083212A1 (en) 2004-09-30
AR043505A1 (en) 2005-08-03

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