TW200410640A - Preparations comprising at least one diformate - Google Patents

Abstract

The present invention relates to coated preparations comprising at least one diformate of the general formula XH(COOH)2, where X is Na, K, Cs, NH4 and to the use thereof.

Description

200410640 (ii) Description of the invention: [Technical field to which the invention belongs] The present invention relates to coated preparations and uses of these preparations, and the preparations include at least one diformate. [Prior art] Acid formate and its preparation method have been familiar to us for a long time. Therefore, Gmelins Handbuch der anorganischen Chemie, 8th edition, No. 21, pages 816 to 819, Verlag Chemie GmbH, Berlin 1928 and 22, pages 919 to 921, Verlag Chemie GmbH, Berlin 1937 are described by Sodium formate and potassium formate are prepared by dissolving sodium formate and potassium formate in formic acid. Crystalline diformate can be obtained by lowering the temperature or evaporating excess formic acid. German Patent No. 424017 discloses the preparation of sodium acid formate with different acid contents by introducing sodium formate into aqueous formic acid at an appropriate molar ratio. The corresponding crystals can be obtained by cooling the solution. According to Jendall et al., Journal of the American Chemical Society, Vol. 43, 1921, pages 1470 to 1481, in order to obtain potassium acid formate, potassium carbonate can be Dissolved in 90% strength formic acid, while generating carbon dioxide. The corresponding solid can be obtained by crystallization. Yango Patent No. 1,505,3 88 discloses the preparation of an acidic carboxylate solution by mixing an acid with a basic compound of the cation in an aqueous solution. Therefore, 'for example' ammonia water is used as a test compound in the preparation of an acidic lysine solution. National Patent No. 4,261,755 describes the reaction of excess gallic acid with lice emulsions, carbonates or bicarbonates suitable for cations to form acid gallate. 86655 200410640 No. 96/3 5657 does not produce products containing the two salts of formic acid, which include potassium, sodium, cesium or dimethylate, bell, sodium or chloric oxide, carbonate or bicarbonate or test Gold, yang, yin, yin, yin, and yin are mixed with selective aqueous osmotic acid, and then the reaction is cold. 'The obtained suspension is filtered and the obtained filter cake is dried and the filtrate is recovered. Unpublished German patent DE 1 01 547 1 5.3 and DE 1 02 107 3 0 · 0 of Shen An'an Mingming's case described the preparation of formate. M formate has an antimicrobial effect and is used, for example, to preserve and acidify plant and animal feed (such as grass), agricultural products or meat, to treat biological waste, or as an additive to livestock nutrients. WO No. 96/3 5337 A1 describes animal feeds and animal feed additives containing diformates, especially potassium diformate. WO No. 97/05 783 A1 (European Patent No. 845 947 Chuanhu) describes a method of preserving fish and using it as a cooling medium having two or four salts of formic acid and / or formic acid. In a specific embodiment, a mono-lattice acid is added to the cooling medium. No. 98/19560 (European Patent No. 957_ 仏) describes a method of making fish feed in which ammonium, sodium or potassium diformate and formic acid are added to the fish product before additional ingredients of the feed are added and processed into fish feed . WO No. 9 8/2091 1 A1 (European Patent No. 9δ1 62〇B1) describes a method for obstructing organic waste in the ground, in which a mono- and di-salt aqueous solution of a formate, acetate or propionate is used Preparation. Section 01A9207 AH Tiger describes a liquid preservative / acidifier for grass and agricultural products, fish and watch products and meat products, which contains at least 50% by weight 86655 200410640 of osmic acid and osmate, ammonium tetraformate and 2- 6% by weight of potassium in the form of a hydroxide or formate or 2-10% by weight of sodium in the form of a hydroxide or a phosphonate. The europium diformate obtained according to European Patent No. EP 0 824 5 1 1 B 1 can be dried in one step after the process. The resulting product is in powder form and usually contains less than 5 weights of 1% water. However, the dicarboxylic acid charge obtainable in this way is not suitable for formulations in complex matrices. Commercially available preparations containing diformate for livestock nutrition can be obtained, for example, in the name of FORMItm, which cannot be incorporated into so-called premixes because the premixes aggregate and / or agglomerate, It makes it impossible to further process the premix into calcium. To prepare the feed, so-called "premixes," or "base mixtures" are prepared from vitamins, minerals, trace elements, organic acids and (where appropriate) enzymes, and they are then mixed with the other ingredients of the feed. The diformates known in the art (Example 2 described in European Patent No. G 824 51 1 B1), one of the premixes, lead to agglomeration and agglomeration and degradation of the premix composition. [Summary of the Invention] It is not clear that one purpose is to provide-机 ... machine using milk 1 dicarboxylic acid into the composite matrix without matrix aggregation or agglomeration becomes possible, for example, into animal feed or animal feed premix. Regarding this' point ::: incomprehensible, this mixture is particularly beneficial. Particularly important complex: Shell, ', Bai Zhi, the so-called basic mixture used to make feed. Koji has discovered that 'this object is obtained by the preparation of the present invention. Therefore, the present invention relates to the preparation of the general formula xh (cooh) a—formaldehyde. The preparation includes at least a formamidine salt, where X is Na, K, Cs, NH4 86655 200410640 "Coated preparations" includes preparations having at least 50%, in particular at least 70% of 3 inches, at least 80%, especially at least 90% of the preparation particle surface preparation. "Coated" "Encapsulated," and "encapsulated" are used synonymously in this text. Corresponding terms, coatings and coatings are used synonymously for encapsulating substances. 比较 Compared to uncoated preparations, coated preparations are particularly compatible with carbonic acid. Exposure to Paula ’s product, Bebe + preparations that do not change. The parameter of the chemical change of the diformate is the release of ^ 〇2. [Embodiment] The present invention includes at least one formula XH (c. OH) 2 bis formic acid, a preparation of one less coating, where X is Na, K, Cs, nh 4. The diphosphonium salt & L | and its preparation are described in the prior art. The phosphonate can be, for example, the method described in European Patent No. 0824 5 丨 丨 Bι or German Patent Application Nos. DE OM1 547 15 3 and DE 1 02 1 07 30_0. The 5-formate salt is sodium diformate, potassium diformate, cesium diformate and Ammonium diformate. In a preferred embodiment, potassium diacetate is used as the diformate. In further embodiments, the diformate can be mixed with each other. `` Diphosphonate '' will be described later Use and include both a preparation containing at least one diformate and a preparation containing a mixture of the diformate. Coatings The coatings available are coatings capable of covering at least 50%, particularly at least 70%, particularly preferably at least 80%, especially at least 90% of all substances on the surface of preparations containing at least one diformate. 86655 200410640 methods of coating containing at least one pi method should make the latter and carbonic acid approximately available in such a way that All the substances of the diformate preparation remain chemically in contact. The following method measures the chemical change of the diacetate as the release of CO2. This is determined by: 20g each of limestone and sample in 100ml (Erie_㈣ The flask was mixed, and the flask was connected to the tube with a connector to measure the water-filled and suspended inverted cylinder. The Erlenmeyer flask was shaken on a shaker plate at 500 Ah / min, and the resulting c was 2 Collected in a measuring cylinder. Detection is performed at room temperature (20.0). Co2 release is detected over 2000, 600, and _min. All compounds suitable for the coating domain for the coated preparation, the The coated preparation contains at least one diformate to which co2 releases less than 100 ml after 200 minutes, in particular less than 50 ml of co2, especially less than 25 ml of co2. The skilled worker should select the coating method according to the coating used. In a preferred embodiment, the coated preparation of the present invention has a coating, the coating comprising at least the following compounds: a group of compounds consisting of the following compounds A) Polyalkylene glycols, especially polyethylene glycols having a number average molecular weight of about 4,000 to 150,000, such as 400 to loooo; b) having a number average molecular weight of about 4,000 to 20,000 Polyoxyalkylene polymers or copolymers, especially block copolymers of polyoxyethylene and polyoxypropylene; c) substituted polystyrene, maleic acid derivatives and styrene / maleic acid copolymers 86655 -10- 200410640; vinylpyridine d) ketone ketones having a number average molecular weight of about ⑻ to 1⑽⑻⑽; e) bite 0¾ / vinyl acetate copolymers having a number average molecular weight of about 30,000 to 100,000; ethylene Base pyrrole f) Polyvinyl polyphthalate having a number average molecular weight of about 10,000 to 200,000; Acetyl alcohol g) Vertexin having a number average molecular weight of about 6,000 to 80,000; Propylfluorene based fiber h) having about 100,000 To the number average molecular weight of 1,000,000 ( I) Alkyl acrylate polymers and copolymers, especially ethyl acrylate / methacrylate methacrylate copolymer and fluorenyl acrylate / ethyl acrylate copolymer having a number average molecular weight of about 250,000 to 700,000. Here again, the purpose of ethylene acetate S is' appropriate use of polyethylenol. Styrene is stable, j) Polyolefins, especially polyethylene; k) Siloxyacetic acid / acetic acid resin; l) Cellulose derivatives, such as ethyl cellulose, ethyl methyl cellulose, methyl cellulose , Hydroxypropyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, cellulose acetate acetate; m) animal, vegetable or synthetic fats;) gravity, plant or synthetic wax or chemically modified Animal, vegetable waxes, such as 7 wax, candelilla wax, carnauba wax, montan ester wax and rice germ oil I, 'Lu Zhi, Wool Moon Purpose, jojoba bug, Sasso (S —) Milk, Japan wax or wild lacquer wax substitutes; 86655 200410640 Power and plant A white matter, such as gelatin, gelatin derivatives, gelatin substitutes, casein, whey, keratin, soy protein, Zein and wheat protein; single # monosaccharides to raise sugars and polysaccharides, for example, rice flour, modified starches and gums, wood yam i, chitosan, and carrageenan; q) vegetable oils such as , Deciduous flower, safflower, cotton loquat, soybean, corn germ, 油 kyou wood (seed), linseed Coriander, coconut, (oil) palm kernel oil and palm oil; 0 synthetic or semi-synthetic oils, such as middle chain length triglycerides or mineral oils; S) animal oils, such as herring, sardines and whale oil; t), two Hardened (hydrogenated or partially hydrogenated) oils / fat, for example, hydrogenated palm oil, hydrogenated cottonseed oil, hydrogenated soybean oil, specifically described above; u) lacquer coatings, such as terpenes, especially shellac, tulu balsam Peruvian balsam, sandarac, and cisternone resins; v) such as fatty acids' saturated and mono- and polyunsaturated to C24 carboxylic acids; w) silica; X) benzoic acid and / or stearic acid Salts and / or benzoic acid esters and / or benzoic acid derivatives and / or benzoic acid derivatives of salts and / or benzoic acid derivatives. These coatings can also be mixed with each other. Examples of suitable polyalkylene glycols a) that should be mentioned are: polypropylene glycol, in particular polyethylene glycols of different molecular weights, such as PEG 4000 or peg 6000, from the patented trade names Lutrol E 4000 and Lutrol E 6000 from Basf AG Get under. Examples of the above polymers b) that should be mentioned are: polyethylene oxide, polyethylene oxide 86655 -12- 200410640 propylene, ethylene oxide / propylene oxide copolymer, and segment copolymerization composed of polyethylene oxide and polypropylene oxide i Properties such as those obtained from Basf under the patented trade names Lutr01F68 and Lmr01Fl27T. Based on the total weight of the solution, it is possible to make the best use of solutions with a high concentration of about 50% by weight, such as a) and b), such as about 30 to 50 weight. 〆〇. An example of the above polymer d) that should be obtained is: the acetic acid base is slightly different, such as sold by BASF AG under the patent trade name K0md〇. And it is best to use a highly concentrated solution of these polymers with a solid content of about 30 to 40 wt./%. Examples of promising polymer solutions that should be obtained are: ... KoHidon VA64 or K〇1Ucat SR sells 1% ethene tol ketone / vinyl acetate copolymer. About 30 to 40% by weight of these copolymers can be used based on the total weight of the solution An example of the above-mentioned polymer 0 that should be mentioned is: such as the product sold by Hoechst under the patent trade name Mowi1. It can be and is best used with A solution of these polymers with a solids content in the range of 20% by weight. Examples of suitable polymers g) that should be mentioned are hydroxypropyl methylcellulose, as patented by Shin Etsu Under the name pharmac〇at. An example of the above-mentioned polymer h) that should be mentioned is: its alkyl group has from 1 to 4 carbon atoms Alkyl (meth) acrylate polymers and copolymers. Specific examples of suitable copolymers that should be mentioned are: by BASF AG under the patent trade name Kollicoat EMM 30D or by Rom (R0hm) under the patent trade name Eudragit A total of 86655 -13-200410640 ethyl acrylate / methyl methacrylate sold under NE 30D and methacrylate / ethyl acrylate copolymers, such as under the brand name Kollicoat MAE 30DP by BASF AG Or sold by ROHM under the patent trade name 1 ^ 1 ^ § 丨 1 30/55. These types of copolymers can be treated as a 10 to 40% by weight dispersion according to the invention. The above mentioned Examples of polymers 丨) are: polyvinyl acetate dispersions, which are stabilized with polyvinylpyrrolidone and sold by BASF AG under the patent trade name Kollicoat SR 30D (approximately 20 to 3 0% by weight of liquid solids).

Month fat, such as fat of animal, plant or synthetic origin, examples of animal fats that can be mentioned: m) are: fat recipes from pigs, cattle, and goose. Tallow is suitable for use. Suitable tallow is available from Cognis under the patented trade name Eden〇I NHIT-G (CAS No. 67701_27_3). Further coatings are gelatins, such as gelatine from pigs, pigs and fish. The additional coating is a butterfly ’such as a’ plant soil, such as candelilla butterfly, Brazilian palm butterfly, rice germ oil soil, wild lacquer _ or wild lacquer _ substitute [Available from Karl-Wassraffny (Kahl Wachsraffk ·, \

(Srafflnene)

Under Japanwachsersatz 2909, you will get 1 tower and a temple of j, a%, such as whale wax palmitate (obtained from Kaunis Co. under the patent sigma + two mouth names Cutma CP, CAS 95912-87-1); animals Waxes, such as lanolin, ^ ^ L ^ I, I, squirrel rat, whale wax; and chemically modified waxes, such as Ximonde wood wax, shade yield, montan vinegar butterfly. In principle, other coatings from solutions are also described, such as sugar coatings. Also consider the use of vegetable oils q),-, 4 s decidification, redness, cotton zinc, big denim, corn germ and olive oil, linseed flaxseed, withdraw sticks, fine +, (oil) palm kernel oil and ( Oil) palm oil. U. palm oil is available from Aarhus Oliefabdk under the patented trade name Vege01 pR 265. Suitable rapeseed oils are available from Aarhus-Ole Manufacturing under the patented Vegeol PR 267. Palm kernel oil is available from Karlshamns under the patented trade name Tefacid palmic 90 (CAS No. 57-10-3). The use of semi-synthetic oils r), for example, middle chain length triglycerides or mineral oils and / or animal oils such as herring, sardines and whale oil is also conceivable. In a preferred embodiment, the coating used is a tritiated vegetable oil t), including triglycerides such as hydrogenated cottonseed, corn, peanut, soybean, palm, palm kernel, babassu, sunflower and safflower oil. . Preferred hydrogenated vegetable oils include hydrogenated palm oil, cottonseed oil, and soybean oil. The most hydrogenated vegetable oil is hydrogenated soybean oil. Other fats and waxes derived from plants and animals are also suitable. The hydrogenated vegetable oils which are preferably used may exist in various polycrystalline forms, and may be in the form of, 3 and β '. In a particularly preferred embodiment of the present invention, hydrogenated vegetable oils of mainly β and β 'type are used, especially those of β type. ", Mainly" means that at least 25%, particularly at least 50%, preferably at least the crystals that are at least grasped are the preferred polymorphs. Extraordinarily good use of β and / with greater than 50%, particularly greater than 75%, and particularly greater than 90%. Or β 'crystal form ratio of hydrogenated soybean oil. In a specific embodiment, the coated preparation of the present invention has a coating comprising at least one compound selected from the group consisting of benzoic acid and / or benzoic acid * 1 and / Or a group consisting of benzoic acid esters and / or benzoic acid derivatives and / or benzoic acid derivatives and / or benzoic acid derivatives. Mention may be made of benzoic acid or benzoic acid derivatives. The salt is benzoic acid metal test 86655 -15-200410640 and / or soil test metal salt and ammonium benzoate. The alkali metal salts to which rhenium and chitosan are mentioned are benzoic acid, sodium, potassium and cesium salts. Sodium benzoate and / Or potassium business # 土 今 属 巡 炎 # and bell dish 4 inches is better. Alkali, calcium, strontium calcium, strontium and magnesium, calcium benzoate and magnesium salts are particularly good. Benzene can be mentioned Formic acid or benzoic acid derivatives: The derivatives of alcohols with alcohols are mono- and difunctional as: diacids: benzoic acid 7 ~ f, 勹 early It is also one of the most versatile and multifunctional (greater than earth). Suitable alcohols are linear and branched alcohols. Alcohols with 丨 to carbon atoms are particularly suitable 'especially with 丨 to 6 carbon atoms. Examples that can be mentioned are ·· Methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol. Methanol, ethanol, n-propanol, and isopropanol are preferred. Stearic acid and stearic acid derivatives of acetic acid ^ It is an ester with an alcohol having more than one hydroxyl group, such as a diol (a propylene glycol may be mentioned as a general example) or a triol (for example, glycerol). Preferably, a benzyl benzate is used. Vinegar, ethyl phenyl benzoate, n-propyl benzoate, and ampoules & L isopropyl | Ethyl p-hydroxybenzoate, sodium methyl p-hydroxybenzoate, propyl p-dibasic acid Ester, sodium propyl p-phenylbenzoate, methyl acetate para-benzoate and sodium p-hydroxybenzyl benzoate. Benzoic acid derivatives are 1, 2, 3, 4 or 5 substituents on the aromatic ring. Examples of the substituents used in the carboxylic acid of the present invention include ci-C8 alkyl, dialkyl, aryl, aralkyl, and arkenyl, hydroxymethyl, c2-C8 hydroxyalkyl, (VC8 hydroxyalkenyl) Amine group, c2_C8 amine alkyl group, cyano group, formamidine group, oxo group, thio group, hydroxy group, thiol group, amine group, carboxyl group or imino group. Preferred substituents are:--8 alkyl group, hydroxyl group Radicals, hydroxy, amine and tertiary radicals. The preferred benzoic acid derivatives are mono-, di- and tri-hydroxy substituted benzoic acids. Examples which may be mentioned are m-hydroxybenzylcarboxylic acid, o-hydroxybenzene Formic acid and p-hydroxybenzoic acid. 86655 -16- 200410640 Examples that may be mentioned are 2,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 2, 6-Dihydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 3,6-dihydroxybenzoic acid and 2,4,6-trihydroxybenzoic acid. Monophenyl substituted benzoic acid is particularly preferred, especially Is p-hydroxybenzoic acid. In a further specific embodiment, the benzoates can be used in combination with each other. Preferred coatings include hydrogenated vegetable oils, including triglycerides, such as hydrogenated cottonseed, corn, peanut, soybean, palm, palm kernel, babassu, safflower and safflower oil. Preferred hydrogenated vegetable oils include hydrogenated palm oil, cottonseed oil, and soybean oil. The most hydrogenated vegetable oil is hydrogenated soybean oil. Other fats and waxes derived from plants and animals are also suitable. The following table contains particularly suitable coatings. Name Composition Melting Range CAS No./INCI Cutina CP, self-synthetic cetyl palmitate 46-51 ° C 95912-87-1 Kaunis Cetyl Palmitate EdenorNHTI-G »Triglyceride 56-60. C 67701-27-3 * from Kaunis EdenorMHTI-V, triglyceride 57-60 ° C 67701-27-3 * from Kaunis EINECS 266-945-8 Japanwachsersatz complex blend of wax esters 49-55 ° C wild lacquer tree 'Karl-Wasley, mainly brown (Rhus succedanea) Finney's acid glycerin purpose Vegeol PR-267 »25% Colzawar 46, 70 ° C from AARHUS OLIE 75% Rucawar FH Vegeol PR-272, 80% Shoguwar FH, 67 ° C from AARHUS OUE 20% Shoguwar 41 Vegeol PR-273, 85% Shoguwar FH, 67 ° C from AARHUS OLffi 15% Shoguwar 41 86655 -17-200410640 Name composition melting range CAS number / INCI Vegeol PR-274 , From AARHUS OLIE 90% Shoguwar FH, 10% Shoguwar 41 67〇C Vegeol PR-275, from AARHUS OLIE 95% Shoguwar FH, 5% Shoguwar 41 67 ° C Vegeol PR-276, from AARHUS OLIE 80% Soyalu FH, 20 % Soyalu41, reacetated 65 〇C Vegeol PR-277, from AARHUS OLIE 85% Soyalu FH, 15% Soyalu 41, reconstituted 65 ° C Vegeol PR-278 ^ From AARHUS OLIE 90% Soyalu FH, 10% Soyalu 41, re-esterified 66〇C Vegeol PR-279, from AARHUS OLIE 95% Soyalu FH, 5% Soyalu 41, reconstituted 67 ° C Tefacid, from Karsham Palm Kernel Oil Tefacid Palmic 90 65〇C 57-10-3 Soy fat powder, from Sankyu / Japan 65-70 ° C Kollicoat EMM 30D, from BASF Company 2-acrylic acid, 2-methyl-, fluorenyl ester and 2-acrylic acid ethyl ester polymer 9010 -88-2 Kollicoat MAE, from BASF's ethyl acrylate / fluorenyl acrylate copolymer 25212-88-8 acrylate copolymer Acronal S 600, from BASF's styrene / acrylate copolymer Diofan 233D, from BASF's partial second Polyvinyl Chloride / Polyvinyl Acrylate Copolymer Poligen WE3 5 from BASF Ethylene / Acrylic Copolymer Dispersion 1286, Paramelt Aquasil PE 1286 Polyethylene Dispersion in Water 86655 -18-200410640, can be used alone or mixed with each other . In the specific embodiment of the present invention, male stones and / or art (such as buddhist stones, feldspars, or feldspars) are added °) Moonstone = Mg3 (OH) 2 / Si4O1Q, also known as soapstone. ~ 50% weight of liquid that can be concentrated and still sprayable as high as possible. /. Aqueous or non-aqueous solution or one or more; for example, ^ ^ 3 / Huang Ye's dispersion. Coatings can also be used in powder form. In a further embodiment, in addition to the diphosphonate, the system of the present invention may include additional ingredients. The choice of additional ingredients depends on the field of choice used to obtain the preparation in this way. The following substances are used for the purposes of the present invention; examples of external ingredients are mentioned: organic acids, vitamins, carotenoids, trace elements, antioxidants, enzymes, amino acids, minerals, emulsifiers, stabilizer preservatives , Adhesives, anticaking agents and / or flavoring agents. In a specific embodiment of the present invention, the preparation of the present invention may additionally include up to ^ short-chain rebel acids and / or at least one short-chain sulfonic acid salt and / or at least one short-chain retarded acid and / or at least A short chain slow acid derivative. Known: ..., the short-acting weilan acid of this meal refers to a carboxylic acid which may be saturated or unsaturated and / or a direct bond or a knife branch or a cyclic and / or aromatic and / or heterocyclic group. According to the present invention, "" short chain "means a carboxylic acid comprising up to 12 carbon atoms, particularly up to 10 carbon atoms, and particularly up to 8 carbon atoms. Short-chain meta-acids generally have a molecular weight of less than 750. According to the intent of the present invention, the short-chain metabotropic acid may have 1, 2, 3 or more carboxyl groups. The carboxyl group may be wholly or partly vinegar, anhydride, lactone, amidine, imine, lactam, limidine, dicarboxide, carbahydrazine, amidine, hydroxamic acid , Hydroxamic acid 'hydrazone, amidoxime or nitrile. 86655 -19-200410640 Derivatives of short-chain winding acids are short-chain carboxylic acids which are mono-, di-, tri- or polysubstituted along the carbon chain or ring structure. Examples of the substituent of the carboxylic acid of the present invention include C! -C8 alkyl, CrC8 alkenyl, aryl, aralkyl, and arkenyl, methylol, C2-C8 hydroxyalkyl, (: 2- (: 8 hydroxyalkenyl, amine methyl, amine alkyl, cyano, fluorenyl, oxo, thio, hydroxy, thiol, amine, carboxyl, or imino. Preferred substituents are C!-C8 alkyl Examples of short-chain carboxylic acids of the present invention are formic acid, acetic acid, propionic acid, butyric acid, lactic acid, citric acid, isobutyric acid, valeric acid, Isovaleric acid, pivalic acid, oxalic acid, malonic acid, salicylic acid, tartaric acid, succinic acid, glutaric acid, glyceric acid, diglycolic acid, adipic acid, pimelic acid, suberic acid, azelaic acid , Sebacic acid, propionic acid, crotonic acid, isocrotonic acid, oleic acid, maleic acid, © maleic acid, muconic acid, citraconic acid, mesaconic acid, camphoric acid, o-, m-, p-_ Acid, naphthalic acid, benzoic acid, hydrogenated atoric acid, atoric acid, isonicotinic cinnamic acid, nicotinic acid, dicarbamic acid, 4,4, -dicyano-6,6 -Mononicotinic acid (4,4'-dicyano-6,6'-dinic otinic acid), 8-Amino acid caprylic acid, 1,2,4-pentanedioic acid, 2-pyrocarboxylic acid, 1,2,4,6,7-naphthalene pentaacetic acid, propionic acid, 4 -Hydroxy o-carboxy benzamidine, 1-pyrazolecarboxylic acid, gallic acid or propyl :): Tritrimonic acid. The short-chain wei acid salts that can be obtained are metal and / or soil metal salts and rhenium Salts. The alkali metal salts that can be mentioned are lithium, sodium, potassium and cesium salts. Sodium and / or potassium salts are particularly preferred. The alkaline earth metal salts that can be mentioned are calcium, gill and magnesium salts, and calcium and magnesium salts are particularly preferred. 'The esters of short-chain carboxylic acids that can be identified are the esters with alcohols. Suitable alcohols are mono- and di-functional 86655-20- 200410640 Both capable and multifunctional (greater than 2 hydroxyl groups). Suitable alcohols are linear and branched alcohols. Both. Preferred suitable alcohols have 1 to 10 carbon atoms, especially 1 to 6 carbon atoms. Examples that can be mentioned are methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutyl Alcohols. Methanol, ethanol, n-propanol, and isopropanol are preferred. Further suitable esters are esters with alcohols having more than one radical, such as glycols (a propylene glycol can be mentioned as an example) Or triol (for example, glycerol). The esters are methyl, ethyl, n-propyl and isopropyl. Particularly preferred are formic acid, acetic acid, propionic acid, fumaric acid, salicylic acid, citric acid, lactic acid and / or tartaric acid and / or salts and / Or ester. It is particularly preferred to use sodium propionate. It is particularly preferred to use the short-chain carboxylic acid as coating w). In a further specific embodiment, the short-chain carboxylic acid, salt and / or vinegar may be used in combination with each other. Suitable compounds are mentioned below under coating X), J Ίυ In further specific embodiments, the preparation of the present invention may include a carrier stone disulfonate. In this embodiment, the diphosphonate is preferably bound to the carrier. Suitable carriers are "inert" carrier substances, ie substances which do not show adverse interactions with the two-use components in the preparations of the invention. Of course, the carrier substance must be poorly acceptable for use as an adjuvant, for example, animal feed. Suitable;: The substance is both inorganic and organic carriers. Examples of suitable carrier substances include: low molecular weight inorganic or organic compounds and high molecular weight natural or organic compounds. Suitable for low-molecular-weight inorganic carriers: is;, such as sodium chloride, calcium carbonate, sodium sulfate, and magnesium sulfate, lean. // Zhongtu or Shi Xiishi i stone derivatives, such as Shi Xixi, Shi Xi acid Salt or stone gum. Suitable for organic loading ^ 86655 -21-, such as sugar, such as glucose, fruit. Mention may be made of high-molecular-weight carbohydrates and dextrin and starch products, in particular examples of corn starch, jade carrier: starch and cellulose carbohydrate powder (eg, wheat flour, wheat flour, wheat flour, mill Crushed rice husks, wheat bran, or mixtures ($ ^, barley flour, and oat flour or bran) or in further specific embodiments thereof. "Additives" refers to & _ # &# The preparations of the month may include additives A to improve product properties, water absorption capacity and storage shell, 'such as improved pulverization properties, flow ^] >, %, Alkaline. Additives and / or mixtures thereof can be sugar (for example, lactose or maltose 7 jade half steak. ^) Polar or leguminous products (for example, Uncle Yushui, wheat bran and soybean flour), except words, 4 ^ Inorganic salts other than scales, sodium, and bell salts and / or lack thereof or their own salts (D-pantothenate prepared by chemical fermentation). The preparations of Bensamine can be mixed with an extra ingredient / knife. , Carriers, and additives. The preparations of the present invention are generally in the form of solid jealousy, such as powders, aggregates, adsorbates, granules, and / or extrudates. And the last I has 1 to 100 μm The average particle size, especially 20 micrometers to 5000 micrometers. The average particle size distribution is determined as follows: The powdery product is studied in a Mastersizer s instrument [from Melvin Instruments GmbH (MaWern Instruments GmbH) 'Serial number: 32734 ; To describe the particle size distribution width, determine the D of the powder (v, oi), D &, 0.5) and D (v, 0.9) values, and indicate the average particle size of the overfeed 〇 [4,3]. Manufacturing methods Suitable methods for manufacturing the preparations of the present invention are all A method for producing a surface covering having a surface coverage of at least 50%, particularly at least 70%, particularly preferably at least 80%, especially at least 900 /. 86655 -22- 200410640. One aspect of the present invention relates to a method for manufacturing the present invention. Method for preparing a product in which the diphosphonate is coated by the sublimation of the coating. In this method, the coating is sublimed and sublimed, that is, deposited on the clothing to be coated. This type of method is used as a sublimation Or the Hua Hua method knows from the literature that the method of this month makes it possible to apply coatings uniformly and at the required layer thickness. The Shiva and Xuanhua methods are described in the Ullmann Encyclopedia of Industrial Chemistry, 6th edition, 2000 electronic edition, Encyclopedia of

Industrial Chemistry, Sixth Edition, 2000 Electronic Release, Qi Qing 4.1). The suitable evaporator (sublimator) is described in m-ioc. The evaporator in Chapter, the condenser (sublimator) is described in Chapter 5.2, and the device design and connection are described in Figures 5 and 6. , 7, 9 and 10, which are clearly referenced here. The fluidized bed can be used as a "condenser" as a possible condenser. In a preferred embodiment, the coating used in the method of the present invention is at least one compound from group X). Substance: ΓΓ ::: Manufacture of a coated preparation containing diformate: Formula: where the diformate is coated with additional ingredients and / or added when appropriate: and the device is coated with a coating, Examples of suitable additional devices that may be mentioned where appropriate are: mixing forces, KUgeicoaters and the like. * Chemical bed, repeating drum According to the intent of the present invention, the best form of powder (for example, shape, adsorbate, extrudate, granules and agglomerates, Chemical bed or mixer. The introduction of dimethylformamide salt is suitable for the acid salt, when appropriate, with the 86655 -23- 200410640 mouth ice addition and additional ingredients. Plowshare (pIowshare), paddle, screw or Analogs ensure greater or lesser vigorous mixing of the product. Conventional examples are ploughshare mixers, runway screw mixers or similar devices. Very shallow, box or trough designs with one or more screws can also be used Further designed as a high speed mixer such as the Turbobolizer (R) Mixer / Applicator and all types of drum applicators or pride applicators Coating drum. Another possibility is to mix the product from the entire container, the movement. An example of this is a drum mixer 'drum mixer or similar. Another possibility is to use a pneumatic mixer. For example,' solid mixing description In Ullmann's Encyclopedia of Hygiene Chemistry 'Brother 6th Edition, 2000, Mixing of solids. Nissho coating can be applied directly downstream of the device in batch or continuous mode. The process can be performed continuously or in batches (in a properly operated mixer). After coating or immediately after / before coating "., A town"% need to add pulverizing agent, such as talc, silicate or the like, to prevent sticking. Dosing / addition of paint is carried out with additional ingredients when appropriate, generally through: device for dripping or spraying Examples are multi-fluid nozzles for syringes, (rarely) rotating drops or atomizing M. In the example, it can be added locally as a concentrated jet stream. In one aspect of the invention, one aspect of the present invention relates to a manufacturing package-,,- A method for preparing a salted coating of a salt of I, in which the coating is introduced into a soil suitable for sturdy soil, and when appropriate, the ingredients are added into the mouth, and the salt is added with additional ingredients and / or strength when appropriate. Additives are added together in the dimethyl aerosol 86655 -24- 200410640 In a specific embodiment of this method, the solid coating is initially placed in a human device, and is heated by the wall or shaft of the device or by mechanical energy into the σ κ valley to melt or soften .plus Dibasic acid salts and (if appropriate) additional ingredients and / or added gases are coated with a melted or softened coating. In a specific embodiment of this method, a carrier is also introduced in addition to the coating, and where appropriate Pre-mixed and due to ττ mechanical energy input in the same or separate device (examples are all mentioned mixers and low-speed flatteners) coated with diphosphonate and (where appropriate) additional ingredients and Additives can be added at superatmospheric, atmospheric or sub-atmospheric pressure, preferably at atmospheric and sub-atmospheric pressure. In some cases, the diformate and (appropriately) When) additional ingredients and / or additives and / or coatings (changing viscosity, changing wettability and affecting curing properties), and feeding or extracting heat through the container wall and / or mixing tool ^. In some cases it may be necessary to remove water vapor or solvent vapor. Wetting properties such as emulsifiers or the like can also be changed by adding surfactants. To improve coating performance, the mixer can be optimally evacuated and covered with a protective gas when appropriate. This should be repeated several times depending on the coating. If necessary, the addition of the diphosphonate, (where appropriate) additional ingredients and / or additives and coatings can be performed in different parts of the device. The place where the coating or additive is added can be changed as needed and selected by skilled staff. The above-mentioned devices for drip or spray coating are arranged on the product layer (upper spray method) or immersed in the product layer (through the device wall from the side or through the device or the bottom of the fluidized bed) as needed. In a further specific embodiment of the present invention, the preparation of the present invention is produced after fluidizing at 86655 -25- 200410640 times. The particles are stirred off in a suitable gas. Produced from 2 or cooled household fluidized gas 甘 lactating limbs (such as nitrogen) are suitable for gas. In some cases, it is worth technically familiar to send or withdraw the volume of the dip & 2 through the wall and port of the container as the surface of the heat exchanger. 'Use the "b bed and necessary peripheral equipment = to measure or continuously measure and (if appropriate) preheat the diformate, (appropriate: and additives) with the help of the above-mentioned core known to skilled staff. Acid salts lead to fluidized beds. They are fluidized and flooded by: soil, water, or non-aqueous solutions or dispersions or melts ... internally known in the art of uncoated solid mixing: : Only 歹 ', square rotator, or Wurster tube or another specially manufactured fluid bed base geometry (base tilt and / or perforation), or sensitive placement of nozzles to help define solid mixing For example, tangentially arranged single- or = -fluid or multi-fluid nozzles. In some cases, coated preparations containing diformate are best manufactured in a combination of a mixer and a fluidized bed. 1¾ The aspect relates to a method of making a coated preparation comprising a diformate, wherein the dicaprate is dispersed, where appropriate, with additional ingredients and / or additives in a melt suitable for coatings, and The obtained dispersion is separated and solidified. In a specific embodiment, the diphosphonate can be suitably used in the form of a melt together with additional ingredients and / or additives. In a further specific embodiment, to obtain the preparation of the present invention, the diphosphonate (and (appropriate) When) additional ingredients and / or additives) are suspended in a melt suitable for coating 86655 -26- 200410640, and allowed to solidify. 7 atomize the dispersion obtained in this way and / or separate the salt Suitable coatings in the state are those with a melting point lower than that of suspension, wax, oil, moon, and shellfish. Examples that can be mentioned are fatty, fatty, and fat-soluble substances with appropriate melting points. Then these counties, body fluids Medium atomization, with and without powdering agent, is a skilled work in a cooled gas method, a coated preparation containing a diformate salt. These granulation or melting packages are well known, For example under jet cooling, jet solidification, smelting is preferred but in the name of land, roll, pelletizing board and belt ... The county floater can be used in a pump / step to produce a use before adding and suspending the diformate or f, 罡,… Ding 4 is also connected, suitable for this Use static mixing: the cryostat and the pipeline are carried by a sufficiently high full flow. The atomizing device is also V. The required parts of the protective heating system-including the pipeline and the horse heat training staff are known. Suitable and preferred as a cooling gas. The gas flow can be carried out in a co-current flow device. Star ", L. This process can be used in conventional jetting, pelletizing towers, or other fluidization with and without hold-up. The bed is also suitable. This system is removed: two batches or continuous operation. Solids can be collected in, for example, cyclones or filters. Consider using and not after-cooling in a fluidized bed or mixer suitable for atomizing device Aσ ^ i is Beizui (early_ and dual-fluid nozzle or special design) and service wheel or atomizing plate or plate or atomizing basket-or its special design. In the specific embodiment of the step-by-step, 'may be two of them' The dispersion obtained in this way is atomized and cured in a liquid in which neither the acid salt nor the coating is soluble. Conventional solid / liquid separation and subsequent dryness produce the preparations of the present invention. 86655 -27 · 200410640 Another aspect of the present invention relates to a method of making a coated preparation comprising a diformate, wherein the diformate is dispersed in a coating with additional ingredients or additives, where appropriate Oil-based coatings, emulsified in an aqueous solution of protective colloids (preferably moon gum or / and Mingsheng derivatives or / and sun and moon gum substitutes) and added—or more than one selected from mono-, di- and polysaccharides The group of substances' is then spray dried. It is preferable to use ultrafine diphosphonate particles in the manufacturing process, and the ultrafine particles are obtained by Shen Dian, crystallization, spray drying or grinding. In a specific embodiment, one or more emulsifiers and / or stabilizers are added to the diformate before dispersing in the lipophilic component. Suitable lipophilic coatings are melts of fats, oils, waxes, lipids, lipids and fat-soluble substances having a melting point below that of the diformate used. The dispersion obtained in this way (diformate-containing oil droplets) is emulsified in an aqueous solution of a protective colloid (preferably gelatin or / and a gelatin derivative or / and a clear substitute) in a subsequent process step ' And adding one or more substances selected from the group consisting of mono-, poly-, and polysaccharides is preferably corn flour. The emulsion obtained in this way is subsequently shaped by spraying and subsequent or simultaneous drying. In a further embodiment, the coated preparations of the present invention include diosmium salt from the carrier to the carrier. The preparations bound to the carrier are manufactured by methods known to the skilled worker, such as ' adsorbing the preparation of the present invention to the carrier in liquid form. Application The preparation of the present invention is suitable for use in animal feed (animal feed). Examples that can be mentioned are: #, cows, poultry and livestock, especially piglets, breeding 86655 -28- 200410640 sows, fat pigs and calves. The preparation of the present invention is particularly suitable for feeding in the form of a feed additive. Added to animals According to the Animai Feeds Aci, feed is added as a substance that is used alone or as a preparation.

Feeds to: J-Affect the properties of animal feed or animal products,-Cover certain animal nutrition or improve animal husbandry, in particular by damage to the gastrointestinal gplex or animal feed digestibility or by reducing animal excreta, $ ^ And some of the temporary feed additives that are required to be used for feeding or covering animals are also available; f: go to: or, soldiers > and daggers as additives in German animal feed 4, paragraph 1, paragraph 1 Under the child number (§ 4, Ρ_ · L No · 3b 〇f th /…

AnimalFeedsAet) Substances approved by legal instruments. Crman The preparation of the present invention is particularly suitable. Pre-, & substance A p mouth, pre-mix to animal feed: "The substance is mineral shellfish, vitamins, amino acids, traces of twist. It can also be made with the preparation of the present invention (, field capture). ^ One T s salt-depleted substance. The present invention relates to a method for making, and / or feed additives, which includes 3-^^ salt feed and 包含 a salt containing diformate. The coating preparation is added with 刭 (m 仏 仏 古 斗, added from π clothing 1 to the premix and ⑴), and the ingredients of the premix agent obtained in this way are mixed. 11 〃, 〇 or feed addition of the present invention The preparations are particularly suitable for reducing pH. These include the so-called "acidifying agents". Acidifying agents refer to substances that reduce the matrix (e.g., animal feed) of PY 86655 -29- 200410640 and substances that reduce the pH of the gastrointestinal tract of animals. The preparation of the present invention is particularly suitable for use as a property enhancer. In a preferred embodiment, the preparation of the present invention is used as a performance enhancer for pigs and poultry. Animal feed compositions should optimally cover the proper nutritional needs of a particular species. -Those generally selected are plant feed ingredients such as corn, wheat or barley flour, unextracted soybean flour, extracted soybean flour, extracted flaxseed flour, two extracted oilseed meal flour, grass flour Or pea flour as a source of crude protein. To ensure that the feed is suitable for Satan-1, add ugly oil or other animal or vegetable fats to the field b. Since vegetable protein sources contain only insufficient amounts of some basic amino acids, feeds are usually supplemented with amino acids. These are especially lysine and methionamine :. To ensure the supply of minerals and vitamins to agriculture and livestock, minerals are also added. The type and amount of minerals and vitamins added are species-dependent and known to skilled workers gA / human shellfish (see, for example, Jeroch et. Al.,

rnahrung landwirtschaftlicher Nutztiere (TTl T NLUZtiere, Ulmer, UTB). It is possible to use dagger to restore the complete feed coverage of all the nutrients that need to be corroded and treated in proportion to each other, and this need. Animals can be formed, or a dietary supplement can be added to the grain diet. This includes the combination of feeds rich in protein, minerals and vitamins in a sensitive way. Feed is further suitable as a preservative, especially as a preservative for green phantom and / or animal feed. It has been found that the present invention can be used advantageously for making silage. 3 accelerate lactic acid fermentation and inhibit the growth of Youbao _ ^ ^ ^ " yeast growth. Therefore, the present invention is directed to the preparation method of the present invention. Use of Ma Yuebei 7 剤 (Silage Aid) 86655 -30- 200410640 Another aspect of the present invention is related to the use of the preparation of the present invention for fertilizer use. All percentage data are by weight. Particle size distribution: Apparatus :: t: The second product was studied in a Masiersizer s instrument (from Melvin Instrument J.G.M. Co., Ltd.,…, 32734-08). The D (V, U), D (V, 0.5), and D (v, 0.9) values were determined to describe the particle's large width, and the average particle size of D (4,3) was specified. Knife cloth The crystals of potassium diformate used in Examples 1 to 4 already contain 2.5% 0-8% Sipernat 22. The particle size distribution of these measurements can be expressed as follows (numbers in parentheses are used for D (v, 0.1) = 208 microns (223 microns) D (v, 0.5) = 402 microns (440 microns) D (v , 0.9) = 666 microns (726 microns) D (4, 3) = 4 19 microns (458 microns) The particle size distribution of the pressed and sprayed particles was determined by sieve analysis.

Tefacid (Kalm) = Palm Kernel Oil 9 (CAS No. 57-10-3)

Sipernat® 22 (Degussa), Ishigaki Example 1a: Dicarboxylic acid was applied in a mixer to obliquely introduce 2500 g of diphosphonic acid bell crystals (D [4,3] = 41 9 microns) into a heatable Plowshare mixer (Loedige type M5 GR) and heated to 53 ° C while mixing at about 60 rpm for about 15 minutes. At the same time, 441 grams of Tefacid ^ u were heated to 76. (: And melt in a drying oven 86655 -31-200410640. Then pour the liquid Tefacid® into the ploughshare mixer over a period of several minutes. Subsequently, the mixture is passed through the ploughshare mixer at the same speed of about 60 rpm for about 1 minute. 0 minutes homogenization. Then the plowshare mixer was switched from heating to cooling by cooling water through the jacket. While stirring, the coated potassium diformate particles were cooled and discharged. A coated two having the following composition was obtained Potassium citrate crystals: 8 5% potassium diformate crystals, 15% but 6 € & (^ (1 coating examples lb to If: The steps are similar to Example 1 a. All examples are operated in a plowshare mixer and produce a Coated products of: 85% potassium diacetate crystals, 15% paint

The temperature of the example coating in the mixer is added to the temperature of the coating before the mixer la Tefacid 53 ° C 76 ° C lb Cutina CP 40 ° C 63 ° C lc Japanwachsersatz 43 ° C 52 ° C Id EdenorNHTI-G 46 ° C 63 ° Cle Vegeol PR 267 58 ° C 77 ° C If Vegeol PR 265 57 ° C 76 ° C Example 2a: Fluidized bed coated potassium diformate crystals The product to be coated includes an average particle size D of about 400-500 microns [ 4, 3] bis (potassium diacetate) crystals. Use Cutina® CP as a coating. -32- 86655 200410640

A Niro-Aeromatic MP-1 laboratory fluidized bed can be used for this test. The receiver used was a plastic cone with a 110 mm substrate inflow plate diameter and a 12% free area perforated substrate. The crystals of potassium diformate (750 g) introduced into the fluidized bed were heated to a product of about 400c / 1HL degree 'while being fluidized with air at a rate of 30 m3 / hour. The paint (1 3 2 g) was melted in a glass beaker in an oil bath at 70 ° C, and a 1.2 mm two-fluid blast was used to spray the heated spray gas at a pressure of 2 bar. Potassium formate crystallized. During the spraying process, to ensure thorough mixing and uniform coating, the air rate was increased to approximately 80 m3 / hour. The spray time was 10 minutes and the product temperature was about 40 ° C. At 35 ° C inlet air temperature, the coated material is cooled in a fluidized bed to a temperature below 40 ° C and discharged. Coated potassium diformate crystals having the following composition: 85% potassium diacetate crystals, 15% CutinaCP coating Examples 2b to 2e: The procedure is similar to that of Example 2a. All examples were operated in an MP 1 laboratory fluidized bed and produced a coated product with the following composition: 85% potassium diformate crystals, 15% paint

Example P The temperature of the product of the coating in a fluidized bed before being added to the fluidized bed 2a Cutina CP 40 ° C 70 ° C 2b Japanwachsersatz 30 ° C 75 ° C 2c Japanwachsersatz 40 ° C 75 ° C 2d Edenor NHTI- G 48 ° C 80 ° C 2e Tefacid 45 ° C 80 ° C 86655 • 33- 200410640 Example 3a: Coating of potassium diformate with a polymer fluidized bed. The product to be coated includes particles having an average particle size of about 400-500 microns. Crystals of potassium diformate of size 0 [4,3]. Kollicoat EMN 30 D was used as the coating.

The Niro-Aeromatic MP-1 laboratory fluidized bed can be used for this test. The receiver used was a plastic cone with a 110 mm base inflow plate diameter and a 12% free area perforated base. The crystals of potassium diformate (750 g) introduced into the fluidized bed were heated to a product temperature of about 25-30 mils while being air-fluidized at a rate of 30 m 3 / h. The coating (440 g of Kollicoat EMN 30D, equivalent to 132 g of solids) was sprayed onto potassium diformate crystals using a 1.2 mm dual fluid nozzle at a spray pressure of 1 to 5 bar. During the spraying process, to ensure thorough mixing and uniform coating, the air rate was increased to approximately 50 m3 / hour. The spray time was 50 minutes. Coated Formi crystals were obtained with the following composition: 85% potassium diacetate crystals, 15% Kollicoat EMN 30 D coating Examples 3b to 3f: The procedure was similar to Example 3a. All examples were operated in an MP 1 laboratory fluidized bed and produced a coated product with the following composition: 85% potassium diformate crystals, 15% paint 34- 86655 200410640

Example coating product temperature in a fluidized bed 3a KollicoatEMN30D < 30 ° C 3b Kollicoat MAE 30 DP + 15% triethyl citrate < 43 ° C 3c Diofan 233 D < 41 ° C 3d Acronal S 600 < 41 ° C 3e Aquasil PE 1286 < 41 ° C 3f Poligen WE 3 < 51 ° C Examples 4a to 4t: Fluidized bed coating with potassium diacetate crystals-Variation of coating thickness -500 μm average particle size D [4,3] potassium diosyrate crystals.

The Niro-Aeromatic MP -1 laboratory fluidized bed can be used for this test. The receiver used was a plastic cone with a 110 mm base inflow plate diameter and a 12% free area perforated base. The steps are similar to Example 2a. In each of Examples 4a to 4t, the temperature of the coating material before it was added to the fluidized bed was 80 ° C. 35- 86655 200410640 Example with coating (%) Cuberate (%) Product temperature (° C) of the coating in a fluidized bed Release with Ca: 200 minutes C 〇 800 minutes L, All: 1000 liters 4a 5.0 95.0 Tefacid 52-57 15 52 80 4b 10.0 90.0 Tefacid 53-56 2 33 72 4c 15.0 85.0 Tefacid 54-56 3 20 28 4d 5.0 95.0 Vegeol PR-267 46-48 2 25 60 4e 10.0 90.0 Vegeol PR-267 44-46 0 0 0 4f 15.0 85.0 Vegeol PR-267 44-46 0 0 0 4g 5.0 95.0 Vegeol PR-272 48 0 0 0 4h 10.0 90.0 Vegeol PR-272 47-51 0 0 0 4i 15.0 85.0 Vegeol PR-272 46-51 0 0 0 4j 15.0 85.0 Vegeol PR-273 50-53 0 0 0 4k 15.0 85.0 Vegeol PR-274 50-54 0 0 0 41 15.0 85.0 Vegeol PR-275 53-56 0 0 0 4m 15.0 85.0 Vegeol PR-276 46-50 0 0 0 4n 5.0 95.0 Vegeol PR-277 47-51 0 0 4o 15.0 85.0 Vegeol PR-277 45-52 0 0 0 4q 5.0 95.0 Vegeol PR-278 51- 53 0 8 26 4r 15.0 85.0 Vegeol PR-278 48-51 0 0 0 4s 5.0 95.0 Vegeol PR-279 51-52 0 0 0 4t 15.0 85.0 Vegeol PR-279 49-53 0 0 0 〇2 released as described in the description Detection shown. As a control value, 002 released from potassium diacetate was detected: after 200 minutes of detection time > 100 ml. The raw materials used in the coating test of Examples 5 and 6 are spray-granulated 400 86655 -36- 200410640. After that, the diacetic acid bell powder with a particle size of micrometer to 2000 micrometers is called potassium diformate spray.制粒。 Making particles. Example 5: Spray granulation of potassium diformate was applied in a mixer. 2,000 grams of potassium diacetate sprayed granules were introduced into a heatable, leather-type mixer (Loedige type M5GR) and heated to 53 times, while Stir at about 60 rpm / 80, about 15 minutes. τ4 ^ and in a drying oven

At the same time, 353 grams of Tefacid® was heated to 76 ° C to melt. The liquid Tefacid was then poured into the ploughshare mixer over several minutes. After returning, the mixture was homogenized in a ploughshare mixer at the same speed of 60 rpm for about 10 minutes. Then the cooling water is switched from self-heating to cooling by the jacket through the jacket. While stirring, the coated potassium diacetate particles were cooled and discharged. Coated potassium diformate spray granules having the following composition were obtained: 85% potassium diacetate spray granules, 15. / 0 Tefacid Coating Example 6: Coating potassium diacetate spray granules in a mixer-adding talc to the coating. 2000 g of potassium monoformate spray granules were introduced into a heatable ploughshare mixer (Loedige type M5GR) and Heat to 53 ° C while stirring at about 60 rpm for about 15 minutes. At the same time, 353 grams of Tefacid® was heated to 76 ° C and melted in a drying oven. Divide the liquid Tefacid® into three equal parts (118 g each) and coat two parts of talc (118 g each). Pour 118 grams of liquid Tefacid® into the ploughshare mixer in about half a minute. Homogenize for 3 minutes and then add the first portion of talc (8 g). Stir in sequence for 3 minutes 86655 -37- 200410640 minutes. Add Tefacid® ’again to perform the same operation as the first addition. Add talc and finally add the final third Tefacid®. The coated talc-coated potassium diformate particles were heated in a rotary jacket with a heating jacket and homogenized for 5 minutes. Then the cooling water is switched from self-heating to cooling by the jacket through the jacket. Simultaneously with the mixing (15 minutes) ', the coated dicarboxylic acid bell particles were cooled and discharged. Coated potassium diformate sprayed particles with a rhenium composition were obtained: 77.2% potassium diformate sprayed particles, 136% Tefacid coating, 9.2% talc Example 7 The coating used in the coating test was 1,000 micrometers The compacted dicarboxylic acid obliquely dried powder to a particle size of 2000 micrometers is hereinafter referred to as a dicarboxylic acid product. The pressed product is produced from the crystal of diacetic acid. Example 7: Coating a diacetate bell pressed product in a mixer Introduce 2000 g of potassium diformate pressed product into a heatable ploughshare mixer (Loedige type M5GR) and heat it to 53 while at about 60 rpm Stir over about 15 minutes. 2 At the same time, heat 353 grams of Tefacid® to 76. O and melted in a drying oven. Pour the liquid Tefacid '# into the ploughshare mixer for a few minutes. Subsequently, the mixture was homogenized in a ploughshare mixer at the same speed of 60 rpm for 10 minutes. Then the cooling water is switched from self-heating to cooling by the jacket through the jacket. While stirring, the coated potassium diacetate compact was cooled and discharged. A coated potassium diformate compact having the following composition was obtained: 85% potassium diacetate compact, 15% Tefacid coating -38-86655

Claims (1)

200410640 Scope of patent application: 1. A coated preparation comprising at least one formamidine salt of the general formula XH (C00H) 2, where X is Na, K, Cs, NH4. 2. A preparation according to item 丨 of the scope of patent application, wherein potassium diformate is used as the diformate. 3. A preparation according to item 1 or 2 of the scope of the patent application, wherein the preparation comprises additional ingredients and / or additives and / or carriers. 4. The preparation according to item 1 or 2 of the scope of the patent application, wherein the coating used is at least one compound selected from the group consisting of: a) poly; A polyethylene glycol having a number average molecular weight of 0 to 150,000, such as 400 to loooo; b) a polyoxyalkylene polymer or copolymer having a number average molecular weight of about 4000 to 20,000, especially polyoxyethylene and Block copolymer of polyoxypropylene; c) substituted polyethylene, maleic acid derivatives, and styrene / maleic acid copolymers; d) polyethylene having a number average molecular weight of about 7,000 to 1,000,000 Extra base I: Lorbitone; e) Ethylpyrrolidone / vinyl acetate copolymer having a number average molecular weight of about 30,000 to 100,000; f) Polyethynol having a number average molecular weight of about 10,000 to 200,000 Polyvinyl phthalate; g) hydroxypropyl fluorenyl cellulose having a number average molecular weight of about 6000 to 80,000; 86655 200410640 h) having a number of about 100,000 to 1 million I (meth) c Dilute acid sintered compounds and copolymers, especially Ethyl acrylate / fluorenyl methyl acrylate copolymer and fluorenyl acrylate / ethyl acrylate copolymer; 1) Polyacetic acid having a number average molecular weight of about 250,000 to 700,000, suitable for 5 g The basic p ratio is slightly more stable. J) Polyenes, especially polyethylene; k) phenoxyacetic acid / formaldehyde resin; l) cellulose derivatives, such as ethyl _ vitamin r ^ f. Ethyl methyl cellulose, methyl cellulose, propyl fiber, hydroxypropyl methyl cellulose, carboxymethyl cellulose, cellulose acetate phthalate; m) animal, plant or synthetic fats; η) animal, plant or synthetic wax or chemical, such as beeswax, candelilla wax, brazilian brown germ oil wax, whale wax, lanolin, wild sumac worm or wild sumac Wax Substitute Animals, Plants, Palm Wax, Montan Ester Wax, Rice Wildwood, Sassokan P) q) and w aqua silver; f-blade dysplasia supplies, casein, dregs, pore alpha keratin, soy protein, corn egg and wheat protein; mono- and disaccharides, xuanxian ^. / Xitang, for example, starch, modified lake and pectin, alginate, | | chitosan and carrageenan; vegetable oils, for example, holes # .., Liuhua, red cesium, cottonseed, soybean , Corn teeth, olive oil, oil), linseed, olive oil, coconut, (> palm oil and palm oil; 86655 200410640 r) synthetic or semi-synthetic oils, such as middle chain length triglycerides or Mineral oils; s) animal oils, such as herring, sardines, and whale oil; t), secondary hardened (hydrogenated or partially hydrogenated) oils / fat, such as hydrogenated palm oil, hydrogenated cottonseed oil, and hydrogenated soybean oil, as specifically described above U) Lacquer coatings, such as terpenes, especially shellac, turquoise balsam, Peruvian Xiangyue, Shantazhi, and syringone resins; V) monthly fatty acid, full-mouthed M leave T7 ^ ^ _ Early-Evening unsaturated C6 to C24 carboxylic acids; w) Shi Xishi; X) benzoic acid and / or benzoic acid salts and / or benzoic acid and / or benzoic acid and / or owed to the living organisms and / Or a salt of a phenylarsinic acid derivative and / or an ester of a phenylarsinic acid derivative. 5. The preparation according to item (1) of the scope of the patent application, which is in the form of a powder having an average particle size in the range of meters to 10 μm, and in particular to 5 μm. 6. · A method of manufacturing according to item 丨 or 2 of the scope of the patent application, wherein (i) at least one diphosphonate is mixed with an appropriate additive, and the coated preparation is mixed with additional ingredients and / or tantalum The mixture obtained in this way is applied with a hair ingredient as appropriate. 、 / 、 A method for manufacturing according to the first scope of the patent application, in which the coated preparations in 2 items are introduced into a suitable device, and octa (Π) is added as appropriate to add the diformate with additional ingredients when appropriate. And / or additive knives—from 86655 200410640 added 8. Seed coating According to the method of Shenyan patent scope No. 1 or 2, the beans are coated with the preparation, and the diformate is formed before coating. Apply quality. j A carrier 9 · A method of manufacturing according to the scope of the patent application, in which the two and two coating preparations omega at least one diphosphonate and, where appropriate, a knife and / or a doser and / or Tim is used in a melt suitable for coatings. (11) Separate and solidify the dispersion obtained in this way. 1 0 · —A method of manufacturing according to the application method, which is a coating preparation of 1 or 2 ⑴ = less-a diphosphonate is dispersed with additional ingredients and / or additives when appropriate- Among these coatings, special materials are lipophilic coatings, =: emulsified in an aqueous solution of sex colloid, preferably Ming knee or / biological or / and gelatin substitutes, and adding-or multiple ^ early-_ and polysaccharide group Substance, and (out) formed by spraying and subsequent or simultaneous drying. 11. A method for manufacturing a coated preparation according to item 1 or 2 of the patent application, which is covered by $, 丨, α. ′, ^ A diformate is applied by the paint's debuffing effect 12: Γ " The use of the preparation of item 1 or 2 of the scope of interest for the premix of knitting. 3. The preparations according to the patent application and / 卞 # 4 or 2 are used as feed additives and / or 'feed' for animal feed. Do not use it for pigs, poultry and calves. 86655 ^ 410640 14. Feed additives And / or animal feed seed manufacturing method comprising at least 15 kinds of dicarboxylic acid, including salt feed and / or feed addition (i) any one of the pre-mixes will be added in accordance with the scope of patent application items 1-5, (U) Mixing the pre-, B-, and hydrazone compounds obtained in this way with feed and / or other ingredients. -An animal feed comprising a patent application according to the patent application. Preparation of the additive system according to item 1 or 2 16. Use according to item 1 or 2 of the scope of patent application and / or growth promoter. 1 7 · According to the scope of patent application 1 or 2 A, preparations for use as acidifying agents Preparations used as property enhancers 18 · According to the scope of patent application 1 or 2 1 9 · According to the scope of patent application Preparations for items 1 or 2 Preparations for use as preservatives Preparations for use as silage agents 20 · Uses of preparations prepared in accordance with item 丨 or 2 of the application for fertilizers 86655 200410640 柒, designated representatives Picture: (1) The designated representative picture in this case is: (). (II) Brief description of the element representative symbols in this representative diagram: 捌 If there is a chemical formula in this case, please disclose the chemical formula that can best show the characteristics of the invention: XH (COOH) 2 (where X is Na, K, Cs, NH4) 86655