TR200101711T2 - Antihistaminik spiro bileşikler. - Google Patents

Antihistaminik spiro bileşikler.

Info

Publication number
TR200101711T2
TR200101711T2 TR2001/01711T TR200101711T TR200101711T2 TR 200101711 T2 TR200101711 T2 TR 200101711T2 TR 2001/01711 T TR2001/01711 T TR 2001/01711T TR 200101711 T TR200101711 T TR 200101711T TR 200101711 T2 TR200101711 T2 TR 200101711T2
Authority
TR
Turkey
Prior art keywords
antihistamine
spiro compounds
formula
compounds
prodrug
Prior art date
Application number
TR2001/01711T
Other languages
English (en)
Inventor
Eduard Janssens Frans
Elisabeth Leenaerts Joseph
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR200101711T2 publication Critical patent/TR200101711T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(FORMÜL VAR) Mevcut bulus formül (I) bilesiklere, bunlara mahsus bir ön ilaca, bir N-oksite, bir katki tuzuna, dördüncül bir amine veya stereokimyasal açidan izomer bir biçime iliskindir. Ayrica bunlarin bir ilaç olarak kullanimlarina, hazirlanmalarina ve bunlari ihtiva eden bilesimlere iliskin bir bulustur.
TR2001/01711T 1998-12-19 1999-12-15 Antihistaminik spiro bileşikler. TR200101711T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98204347 1998-12-19

Publications (1)

Publication Number Publication Date
TR200101711T2 true TR200101711T2 (tr) 2001-12-21

Family

ID=8234498

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01711T TR200101711T2 (tr) 1998-12-19 1999-12-15 Antihistaminik spiro bileşikler.

Country Status (37)

Country Link
US (2) US7148214B1 (tr)
EP (1) EP1144411B1 (tr)
JP (1) JP4601175B2 (tr)
KR (1) KR100598725B1 (tr)
CN (1) CN1258533C (tr)
AR (1) AR021888A1 (tr)
AT (1) ATE294178T1 (tr)
AU (1) AU764820C (tr)
BG (1) BG65133B1 (tr)
BR (1) BR9916371A (tr)
CA (1) CA2355939C (tr)
CO (1) CO5140116A1 (tr)
CZ (1) CZ301953B6 (tr)
DE (1) DE69925036T2 (tr)
DK (1) DK1144411T3 (tr)
EA (1) EA004500B1 (tr)
EE (1) EE04917B1 (tr)
EG (1) EG24605A (tr)
ES (1) ES2242443T3 (tr)
HK (1) HK1043128B (tr)
HR (1) HRP20010453B1 (tr)
HU (1) HU229406B1 (tr)
ID (1) ID29268A (tr)
IL (1) IL143767A0 (tr)
MY (1) MY129663A (tr)
NO (1) NO318891B1 (tr)
NZ (1) NZ512870A (tr)
PL (1) PL196262B1 (tr)
PT (1) PT1144411E (tr)
SA (1) SA00210113B1 (tr)
SI (1) SI1144411T1 (tr)
SK (1) SK286158B6 (tr)
TR (1) TR200101711T2 (tr)
TW (1) TWI250981B (tr)
UA (1) UA74537C2 (tr)
WO (1) WO2000037470A1 (tr)
ZA (1) ZA200104977B (tr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7390822B2 (en) 2001-10-15 2008-06-24 Janssen Pharmaceutica, N.V. Substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives for reducing ischaemic damage
KR100898562B1 (ko) * 2001-10-15 2009-05-20 얀센 파마슈티카 엔.브이. 신규 치환된 4-페닐-4-[1ｈ-이미다졸-2-일]-피페리딘유도체 및 선택적인 비펩타이드 델타 아편유사작용제로서의 그의 용도
WO2005110685A2 (en) * 2004-05-11 2005-11-24 Alliss George E Vegetation trimmer apparatus
US7960402B2 (en) * 2004-09-07 2011-06-14 Banyu Pharmaceutical Co., Ltd. Carbamoyl-substituted spiro derivative
BRPI0911577B8 (pt) 2008-04-29 2021-05-25 Novartis Ag derivados espiro-indol, seus usos no tratamento de doenças parasíticas, e composição farmacêutica
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2014329392B2 (en) 2013-10-04 2018-12-20 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2015231413B2 (en) 2014-03-19 2020-04-23 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
CA2959208C (en) 2014-08-29 2023-09-19 Tes Pharma S.R.L. Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2016322552B2 (en) 2015-09-14 2021-03-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017088080A1 (es) 2015-11-25 2017-06-01 Natural Response S.A. Método para la obtención de saponinas a partir de plantas
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20240052355A (ko) 2022-10-14 2024-04-23 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. 여과 장치용 커버
KR20240052354A (ko) 2022-10-14 2024-04-23 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. 여과 장치
CN117624052B (zh) * 2024-01-26 2024-04-12 四川益能康生环保科技有限公司 一种用于捕集二氧化碳的离子液体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464380A (en) 1983-05-25 1984-08-07 Pfizer Inc. Imidazolidinedione derivatives
PH30434A (en) 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
AU8902591A (en) * 1990-10-10 1992-05-20 Schering Corporation Substituted imidazobenzazepines and imidazopyridoazepines
IL101851A (en) 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
US5106844A (en) * 1991-09-10 1992-04-21 Sterling Drug Inc. Imidazo[2,2-b][3]benzazepine and pyrimido[2,1-b][3]benzazepine antiarrhythmic agents
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Also Published As

Publication number Publication date
BG65133B1 (bg) 2007-03-30
CA2355939A1 (en) 2000-06-29
AU764820B2 (en) 2003-08-28
WO2000037470A8 (en) 2000-08-24
UA74537C2 (uk) 2006-01-16
HRP20010453B1 (en) 2010-07-31
HRP20010453A2 (en) 2002-06-30
SA00210113B1 (ar) 2006-09-13
HK1043128A1 (en) 2002-09-06
ES2242443T3 (es) 2005-11-01
EA200100681A1 (ru) 2001-12-24
HUP0104779A3 (en) 2003-12-29
JP4601175B2 (ja) 2010-12-22
HU229406B1 (en) 2013-12-30
BR9916371A (pt) 2001-09-18
CN1258533C (zh) 2006-06-07
PT1144411E (pt) 2005-09-30
ATE294178T1 (de) 2005-05-15
EE04917B1 (et) 2007-10-15
WO2000037470A1 (en) 2000-06-29
HUP0104779A2 (hu) 2002-04-29
CZ20012069A3 (cs) 2002-02-13
US7148214B1 (en) 2006-12-12
BG105546A (en) 2001-12-29
SK286158B6 (sk) 2008-04-07
NO20012710D0 (no) 2001-06-01
PL196262B1 (pl) 2007-12-31
NZ512870A (en) 2003-11-28
SI1144411T1 (en) 2005-10-31
NO20012710L (no) 2001-06-01
ZA200104977B (en) 2002-06-18
EP1144411A1 (en) 2001-10-17
AR021888A1 (es) 2002-08-07
ID29268A (id) 2001-08-16
EG24605A (en) 2010-01-10
KR100598725B1 (ko) 2006-07-11
CZ301953B6 (cs) 2010-08-11
JP2002533344A (ja) 2002-10-08
EE200100328A (et) 2002-08-15
PL348295A1 (en) 2002-05-20
AU3041200A (en) 2000-07-12
NO318891B1 (no) 2005-05-18
DK1144411T3 (da) 2005-09-19
US20050026901A1 (en) 2005-02-03
EP1144411B1 (en) 2005-04-27
CN1331694A (zh) 2002-01-16
EA004500B1 (ru) 2004-04-29
HK1043128B (zh) 2007-01-19
CO5140116A1 (es) 2002-03-22
AU764820C (en) 2004-11-18
MY129663A (en) 2007-04-30
DE69925036T2 (de) 2006-01-26
CA2355939C (en) 2010-12-14
IL143767A0 (en) 2002-04-21
KR20010075655A (ko) 2001-08-09
US7087595B2 (en) 2006-08-08
SK8142001A3 (en) 2002-04-04
TWI250981B (en) 2006-03-11
DE69925036D1 (de) 2005-06-02

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