TR199901487T2 - Enzymatic resolutions of benzodiazepine-acetic acid esters containing a lipase. - Google Patents

Enzymatic resolutions of benzodiazepine-acetic acid esters containing a lipase.

Info

Publication number
TR199901487T2
TR199901487T2 TR1999/01487T TR9901487T TR199901487T2 TR 199901487 T2 TR199901487 T2 TR 199901487T2 TR 1999/01487 T TR1999/01487 T TR 1999/01487T TR 9901487 T TR9901487 T TR 9901487T TR 199901487 T2 TR199901487 T2 TR 199901487T2
Authority
TR
Turkey
Prior art keywords
acetic acid
acid esters
benzodiazepine
lipase
esters containing
Prior art date
Application number
TR1999/01487T
Other languages
Turkish (tr)
Inventor
Stephen Wells Andrew
Original Assignee
Smithkline Beecham Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc. filed Critical Smithkline Beecham Plc.
Publication of TR199901487T2 publication Critical patent/TR199901487T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Bu bulus, enantiomerik olarak saf benzodiazepin asetik asit esterleri ve bir lipazin kullanilmasi ile bir rasemik karisimin çözülmesi suretiyle bunlarin hazirlanmasi ile ilgilidir.This invention relates to the use of enantiomerically pure benzodiazepine acetic acid esters and a lipazine to prepare them by dissolving a racemic mixture.

TR1999/01487T 1996-12-27 1997-12-23 Enzymatic resolutions of benzodiazepine-acetic acid esters containing a lipase. TR199901487T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3385396P 1996-12-27 1996-12-27

Publications (1)

Publication Number Publication Date
TR199901487T2 true TR199901487T2 (en) 1999-11-22

Family

ID=21872833

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01487T TR199901487T2 (en) 1996-12-27 1997-12-23 Enzymatic resolutions of benzodiazepine-acetic acid esters containing a lipase.

Country Status (17)

Country Link
EP (1) EP0964928A1 (en)
JP (1) JP2001507231A (en)
KR (1) KR20000069705A (en)
CN (1) CN1246157A (en)
AR (1) AR010860A1 (en)
AU (1) AU730064B2 (en)
BR (1) BR9714099A (en)
CA (1) CA2276134A1 (en)
CO (1) CO4930272A1 (en)
HU (1) HUP0002825A3 (en)
IL (1) IL130580A0 (en)
NO (1) NO993174D0 (en)
NZ (1) NZ336376A (en)
PL (1) PL334293A1 (en)
TR (1) TR199901487T2 (en)
WO (1) WO1998029561A1 (en)
ZA (1) ZA9711566B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69914458T2 (en) * 1998-02-17 2004-10-28 G.D. Searle & Co., Chicago METHOD FOR ENZYMATICALLY DISCHARGING LACTAS
EP1290208B1 (en) * 2000-06-01 2010-10-13 SK Holdings Co., Ltd. Method for optically resolving a racemic alpha-substituted heterocyclic carboxylic acid using enzyme
KR100378741B1 (en) * 2000-06-01 2003-04-07 에스케이 주식회사 Method for preparing R- or S-form α-substituted heterocyclic carboxyl acid and counter enantiomeric form of α-substituted heterocyclic carboxyl acid ester thereto using enzyme
KR100379756B1 (en) * 2000-10-02 2003-04-11 한국과학기술연구원 Resolution of chiral compounds
US6828119B2 (en) * 2001-01-04 2004-12-07 Bristol Myers Squibb Company Enzymatic deprotection of amines and hydroxides
FR2853327B1 (en) * 2003-04-04 2012-07-27 Solvay PROCESS FOR THE PRODUCTION OF ENANTIOPOR BETA-AMINOACID DERIVATIVES AND ENANTIOPA BETA-AMINOACIDIC DERIVATIVES
KR100650798B1 (en) * 2004-07-19 2006-11-27 (주)제이코통상 Process for preparing chiral substituted carboxylic acid
FR2876102A1 (en) * 2004-10-04 2006-04-07 Solvay ENANTIOPUR HETEROCYCLIC COMPOUND
KR100650797B1 (en) * 2005-12-12 2006-11-27 (주)케미코월드 Process for preparing chiral substituted cyclopropane carboxamide
FR2986804A1 (en) * 2012-02-09 2013-08-16 Servier Lab PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S) 3,4-DIMETHOXYBICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-CARBOXYLIC ACID OR ITS ESTERS, AND APPLICATION TO THE SYNTHESIS OF IVABRADIN AND IES SALTS
CN117363683A (en) * 2023-10-09 2024-01-09 江苏惠利生物科技有限公司 Enzymatic resolution method of lipase benzodiazepine-acetate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT100631B (en) * 1991-06-28 1999-06-30 Smithkline Beecham Corp BICYCLE FIBRINOGENIC ANTAGONISTS, ITS USE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
CN1041921C (en) * 1992-12-21 1999-02-03 史密丝克莱恩比彻姆公司 Bicyclic fibrinogen antagonists
MA23420A1 (en) * 1994-01-07 1995-10-01 Smithkline Beecham Corp BICYCLIC FIBRINOGEN ANTAGONISTS.
US5529929A (en) * 1995-06-07 1996-06-25 Seprachem, Inc. Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens

Also Published As

Publication number Publication date
AU5331498A (en) 1998-07-31
NO993174L (en) 1999-06-25
HUP0002825A3 (en) 2002-09-30
AR010860A1 (en) 2000-07-12
PL334293A1 (en) 2000-02-14
CO4930272A1 (en) 2000-06-27
WO1998029561A1 (en) 1998-07-09
EP0964928A1 (en) 1999-12-22
AU730064B2 (en) 2001-02-22
ZA9711566B (en) 1998-06-29
CA2276134A1 (en) 1998-07-09
IL130580A0 (en) 2000-06-01
CN1246157A (en) 2000-03-01
BR9714099A (en) 2000-03-21
NO993174D0 (en) 1999-06-25
NZ336376A (en) 2000-11-24
JP2001507231A (en) 2001-06-05
HUP0002825A2 (en) 2000-12-28
KR20000069705A (en) 2000-11-25

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