SK2942002A3 - A conjugate exhibiting interferon beta, a nucleotide sequence, an expressing vector, a host cell containing such a nucleotide sequence, method for the preparation thereof, pharmaceutical composition containing the same and its use - Google Patents

A conjugate exhibiting interferon beta, a nucleotide sequence, an expressing vector, a host cell containing such a nucleotide sequence, method for the preparation thereof, pharmaceutical composition containing the same and its use Download PDF

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Publication number
SK2942002A3
SK2942002A3 SK294-2002A SK2942002A SK2942002A3 SK 2942002 A3 SK2942002 A3 SK 2942002A3 SK 2942002 A SK2942002 A SK 2942002A SK 2942002 A3 SK2942002 A3 SK 2942002A3
Authority
SK
Slovakia
Prior art keywords
polypeptide
interferon
conjugate
amino acid
moiety
Prior art date
Application number
SK294-2002A
Other languages
English (en)
Slovak (sk)
Inventor
Anders Hjelholt Pedersen
Hans Thalsgaard Schambye
Kim Vilbour Andersen
Claus Bornaes
Poul Baad Rasmussen
Original Assignee
Maxygen Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxygen Aps filed Critical Maxygen Aps
Publication of SK2942002A3 publication Critical patent/SK2942002A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SK294-2002A 1999-08-27 2000-08-25 A conjugate exhibiting interferon beta, a nucleotide sequence, an expressing vector, a host cell containing such a nucleotide sequence, method for the preparation thereof, pharmaceutical composition containing the same and its use SK2942002A3 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA199901197 1999-08-27
US16078299P 1999-10-21 1999-10-21
DKPA199901691 1999-11-26
DKPA200000194 2000-02-07
DKPA200000363 2000-03-07
DKPA200000642 2000-04-14
PCT/DK2000/000471 WO2001015736A2 (en) 1999-08-27 2000-08-25 Interferon-beta conjugates

Publications (1)

Publication Number Publication Date
SK2942002A3 true SK2942002A3 (en) 2002-08-06

Family

ID=27545189

Family Applications (1)

Application Number Title Priority Date Filing Date
SK294-2002A SK2942002A3 (en) 1999-08-27 2000-08-25 A conjugate exhibiting interferon beta, a nucleotide sequence, an expressing vector, a host cell containing such a nucleotide sequence, method for the preparation thereof, pharmaceutical composition containing the same and its use

Country Status (14)

Country Link
EP (1) EP1328295A2 (pt)
JP (1) JP2003527090A (pt)
KR (1) KR20020034181A (pt)
CN (1) CN1501815A (pt)
AU (1) AU6687000A (pt)
BR (1) BR0013638A (pt)
CA (1) CA2380760A1 (pt)
CZ (1) CZ2002521A3 (pt)
HU (1) HUP0302674A2 (pt)
IL (1) IL147581A0 (pt)
MX (1) MXPA02001969A (pt)
NO (1) NO20020929L (pt)
SK (1) SK2942002A3 (pt)
WO (1) WO2001015736A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ300762B6 (cs) 1998-10-16 2009-08-05 Biogen Idec Ma Inc. Fúzní proteiny interferonu-beta-1a a jejich použití
PT1656952E (pt) 1998-10-16 2014-02-21 Biogen Idec Inc Conjugados de polietileno-glicol e interferão beta 1a e as suas utilizações
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US7431921B2 (en) 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
EP1334128A2 (en) * 2000-11-02 2003-08-13 Maxygen Aps New multimeric interferon beta polypeptides
HUP0303251A2 (hu) * 2001-02-27 2003-12-29 Maxygen Aps Béta-interferon-szerű molekulák
AU2002254174A1 (en) * 2001-03-13 2002-09-24 Vical Incorporated Interferon-beta polynucleotide therapy for autoimmune and inflammatory diseases
KR100511749B1 (ko) * 2001-11-06 2005-09-02 선바이오(주) 변형된 인터페론-베타, 및 이의 화학적으로 변형된 배합체
JP2005526151A (ja) 2002-01-18 2005-09-02 バイオゲン アイデック エムエー インク． 生物学的に活性な化合物の結合のための部分を有するポリアルキレングリコール
AU2003254641A1 (en) * 2002-08-28 2004-03-19 Maxygen Aps Interferon beta-like molecules for treatment of cancer
TWI406672B (zh) 2002-12-26 2013-09-01 Mountain View Pharmaceuticals 生物效力增進的β干擾素聚合物共軛體
CN100519581C (zh) * 2003-08-25 2009-07-29 东丽株式会社 干扰素-β复合物
EP1674113A1 (en) * 2004-12-22 2006-06-28 F. Hoffmann-La Roche Ag Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol)
EP2059528A2 (en) * 2006-08-08 2009-05-20 Novartis Ag Recombinant interferon-beta with enhanced biological activity
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
CL2008002399A1 (es) * 2007-08-16 2009-01-02 Pharmaessentia Corp Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
CN104043112B (zh) * 2014-07-01 2016-03-30 哈药集团生物工程有限公司 一种含有重组人干扰素α-2b(假单胞菌)的软膏药物组合物
KR102724837B1 (ko) 2014-11-06 2024-10-31 파마에센시아 코퍼레이션 Peg화된 인터페론의 투약 요법
EP3454887B1 (en) * 2016-05-13 2021-01-20 Orionis Biosciences BV Targeted mutant interferon-beta and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2524586B2 (ja) * 1985-06-26 1996-08-14 シタス コーポレイション ポリマ−接合を利用する医薬組成物用蛋白質の可溶化
US4917888A (en) * 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
IL113280A (en) * 1994-04-12 2004-12-15 Res Dev Foundation A preparation for the treatment of self-immunization diseases with the help of interferon of one type
US5738846A (en) * 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
JP2001511162A (ja) * 1997-02-06 2001-08-07 ノボ ノルディスク アクティーゼルスカブ 付加され、そして／又は除去された付着基を有するポリペプチド−ポリマー結合体
BR9812267B1 (pt) * 1997-07-14 2013-11-26 Hormônio de crescimento recombinante.
PT1656952E (pt) * 1998-10-16 2014-02-21 Biogen Idec Inc Conjugados de polietileno-glicol e interferão beta 1a e as suas utilizações

Also Published As

Publication number Publication date
NO20020929D0 (no) 2002-02-26
EP1328295A2 (en) 2003-07-23
CN1501815A (zh) 2004-06-02
HUP0302674A2 (hu) 2003-11-28
WO2001015736A2 (en) 2001-03-08
NO20020929L (no) 2002-04-25
WO2001015736A3 (en) 2003-05-22
CA2380760A1 (en) 2001-03-08
JP2003527090A (ja) 2003-09-16
BR0013638A (pt) 2002-05-14
CZ2002521A3 (cs) 2002-05-15
KR20020034181A (ko) 2002-05-08
MXPA02001969A (es) 2003-07-21
IL147581A0 (en) 2002-08-14
AU6687000A (en) 2001-03-26

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