SI3191476T1 - Tetrahidrokinolinski derivati kot inhibitorji bromodomene - Google Patents

Tetrahidrokinolinski derivati kot inhibitorji bromodomene

Info

Publication number
SI3191476T1
SI3191476T1 SI201530529T SI201530529T SI3191476T1 SI 3191476 T1 SI3191476 T1 SI 3191476T1 SI 201530529 T SI201530529 T SI 201530529T SI 201530529 T SI201530529 T SI 201530529T SI 3191476 T1 SI3191476 T1 SI 3191476T1
Authority
SI
Slovenia
Prior art keywords
bromodomain inhibitors
tetrahydroquinoline derivatives
tetrahydroquinoline
derivatives
bromodomain
Prior art date
Application number
SI201530529T
Other languages
English (en)
Inventor
Stephen John Atkinson
David Jonathan Hirst
Philip G. Humphreys
Matthew J. Lindon
Alexander G. Preston
Jonathan Thomas Seal
Christopher Roland Wellaway
Original Assignee
Glaxosmithkline Intellectual Property (No.2) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Intellectual Property (No.2) Limited filed Critical Glaxosmithkline Intellectual Property (No.2) Limited
Publication of SI3191476T1 publication Critical patent/SI3191476T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201530529T 2014-09-12 2015-09-09 Tetrahidrokinolinski derivati kot inhibitorji bromodomene SI3191476T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462049449P 2014-09-12 2014-09-12
PCT/EP2015/070665 WO2016038120A1 (en) 2014-09-12 2015-09-09 Tetrahydroquinoline derivatives as bromodomain inhibitors
EP15760461.2A EP3191476B1 (en) 2014-09-12 2015-09-09 Tetrahydroquinoline derivatives as bromodomain inhibitors

Publications (1)

Publication Number Publication Date
SI3191476T1 true SI3191476T1 (sl) 2019-01-31

Family

ID=54065889

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201530529T SI3191476T1 (sl) 2014-09-12 2015-09-09 Tetrahidrokinolinski derivati kot inhibitorji bromodomene

Country Status (35)

Country Link
US (1) US10059699B2 (sl)
EP (1) EP3191476B1 (sl)
JP (1) JP6531167B2 (sl)
KR (1) KR20170054421A (sl)
CN (1) CN106687453B (sl)
AR (1) AR101806A1 (sl)
AU (1) AU2015314184B2 (sl)
BR (1) BR112017004580A2 (sl)
CA (1) CA2958159A1 (sl)
CL (1) CL2017000587A1 (sl)
CO (1) CO2017001601A2 (sl)
CR (1) CR20170090A (sl)
CY (1) CY1121369T1 (sl)
DK (1) DK3191476T3 (sl)
DO (1) DOP2017000058A (sl)
EA (1) EA031679B9 (sl)
ES (1) ES2705623T3 (sl)
HR (1) HRP20182064T1 (sl)
HU (1) HUE041694T2 (sl)
IL (1) IL250397A0 (sl)
LT (1) LT3191476T (sl)
MA (1) MA40366A (sl)
MX (1) MX2017003219A (sl)
PE (1) PE20170675A1 (sl)
PH (1) PH12017500348B1 (sl)
PL (1) PL3191476T3 (sl)
PT (1) PT3191476T (sl)
RS (1) RS58135B1 (sl)
SG (1) SG11201701043UA (sl)
SI (1) SI3191476T1 (sl)
TR (1) TR201820050T4 (sl)
TW (1) TWI686389B (sl)
UY (1) UY36292A (sl)
WO (1) WO2016038120A1 (sl)
ZA (1) ZA201700883B (sl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20151727A1 (es) 2013-03-14 2015-12-17 Boehringer Ingelheim Int Acido 2-aza-biciclo[2.2.1]heptano-3-carboxilico (bencil-ciano-metil)-amidas sustituidas inhibidores de catepsina c
EP3191487B1 (en) 2014-09-12 2019-08-07 Boehringer Ingelheim International GmbH Spirocyclic inhibitors of cathepsin c
WO2018111805A1 (en) 2016-12-13 2018-06-21 St. Jude Children's Research Hospital Tetrahydroquinoline-based bromodomain inhibitors
AU2019372121A1 (en) 2018-10-30 2021-05-27 Nuvation Bio Inc. Heterocyclic compounds as BET inhibitors
KR102677015B1 (ko) 2019-07-02 2024-06-19 누베이션 바이오 인크. Bet 억제제로서의 헤테로시클릭 화합물
EP4095128A1 (en) 2021-05-25 2022-11-30 Centre national de la recherche scientifique Tetrahydroquinoline (thq) coumpounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2415764A4 (en) * 2009-03-31 2012-08-08 Kowa Co PROPHYLACTIC AND / OR THERAPEUTIC AGENT AGAINST ANEMIA WITH A TETRAHYDROCHINOLINE COMPOUND AS AN ACTIVE SUBSTANCE
GB0919431D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
GB0919432D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Use
GB0919434D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
GB201106743D0 (en) 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
GB201106750D0 (en) 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
GB201107325D0 (en) 2011-05-04 2011-06-15 Glaxosmithkline Llc Novel compounds
NZ710765A (en) * 2013-03-14 2020-05-29 Glaxosmithkline Ip No 2 Ltd 2,3-disubstituted 1 -acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors

Also Published As

Publication number Publication date
CN106687453A8 (zh) 2017-06-30
JP6531167B2 (ja) 2019-06-12
PH12017500348A1 (en) 2017-07-17
PE20170675A1 (es) 2017-06-13
RS58135B1 (sr) 2019-02-28
TW201625587A (zh) 2016-07-16
CY1121369T1 (el) 2020-05-29
EP3191476A1 (en) 2017-07-19
TR201820050T4 (tr) 2019-01-21
CL2017000587A1 (es) 2017-10-06
AU2015314184B2 (en) 2018-09-13
PL3191476T3 (pl) 2019-04-30
CR20170090A (es) 2017-05-08
PT3191476T (pt) 2019-01-17
BR112017004580A2 (pt) 2018-01-23
EA031679B1 (ru) 2019-02-28
DOP2017000058A (es) 2017-06-15
MA40366A (fr) 2017-07-19
KR20170054421A (ko) 2017-05-17
SG11201701043UA (en) 2017-03-30
CN106687453B (zh) 2019-07-19
ZA201700883B (en) 2021-08-25
US10059699B2 (en) 2018-08-28
EA201790484A1 (ru) 2017-10-31
EP3191476B1 (en) 2018-10-24
ES2705623T3 (es) 2019-03-26
HRP20182064T1 (hr) 2019-02-08
LT3191476T (lt) 2019-01-10
WO2016038120A1 (en) 2016-03-17
HUE041694T2 (hu) 2019-05-28
EA031679B9 (ru) 2019-04-30
AR101806A1 (es) 2017-01-11
DK3191476T3 (en) 2019-01-14
JP2017526718A (ja) 2017-09-14
CO2017001601A2 (es) 2017-07-28
IL250397A0 (en) 2017-03-30
CA2958159A1 (en) 2016-03-17
CN106687453A (zh) 2017-05-17
MX2017003219A (es) 2017-06-19
PH12017500348B1 (en) 2017-07-17
AU2015314184A1 (en) 2017-03-09
TWI686389B (zh) 2020-03-01
UY36292A (es) 2016-04-29
US20170298047A1 (en) 2017-10-19

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