SG11201705475QA - Fcrn antibodies and methods of use thereof - Google Patents

Fcrn antibodies and methods of use thereof

Info

Publication number
SG11201705475QA
SG11201705475QA SG11201705475QA SG11201705475QA SG11201705475QA SG 11201705475Q A SG11201705475Q A SG 11201705475QA SG 11201705475Q A SG11201705475Q A SG 11201705475QA SG 11201705475Q A SG11201705475Q A SG 11201705475QA SG 11201705475Q A SG11201705475Q A SG 11201705475QA
Authority
SG
Singapore
Prior art keywords
methods
fcrn antibodies
fcrn
antibodies
Prior art date
Application number
SG11201705475QA
Inventor
Marilyn Kehry
David J King
Leona E Ling
James Meador Iii
Sucharita Roy
Anthony Manning
Original Assignee
Momenta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Momenta Pharmaceuticals Inc filed Critical Momenta Pharmaceuticals Inc
Publication of SG11201705475QA publication Critical patent/SG11201705475QA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Nutrition Science (AREA)
SG11201705475QA 2015-01-30 2016-01-29 Fcrn antibodies and methods of use thereof SG11201705475QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562110071P 2015-01-30 2015-01-30
US201562258082P 2015-11-20 2015-11-20
PCT/US2016/015720 WO2016123521A2 (en) 2015-01-30 2016-01-29 Fcrn antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201705475QA true SG11201705475QA (en) 2017-08-30

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202007232WA SG10202007232WA (en) 2015-01-30 2016-01-29 Fcrn antibodies and methods of use thereof
SG11201705475QA SG11201705475QA (en) 2015-01-30 2016-01-29 Fcrn antibodies and methods of use thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202007232WA SG10202007232WA (en) 2015-01-30 2016-01-29 Fcrn antibodies and methods of use thereof

Country Status (21)

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US (3) US10676526B2 (en)
EP (2) EP4286011A3 (en)
JP (2) JP6853178B2 (en)
KR (2) KR102483016B1 (en)
CN (13) CN118667015A (en)
AU (1) AU2016211280B2 (en)
CA (1) CA2972822A1 (en)
DK (1) DK3250610T3 (en)
ES (1) ES2962824T3 (en)
FI (1) FI3250610T3 (en)
HR (1) HRP20231399T1 (en)
HU (1) HUE063778T2 (en)
IL (1) IL252837B (en)
LT (1) LT3250610T (en)
NZ (1) NZ733097A (en)
PL (1) PL3250610T3 (en)
PT (1) PT3250610T (en)
RS (1) RS64768B1 (en)
SG (2) SG10202007232WA (en)
SI (1) SI3250610T1 (en)
WO (1) WO2016123521A2 (en)

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US10676526B2 (en) 2015-01-30 2020-06-09 Momenta Pharmaceuticals, Inc. FcRn antibodies and methods of use thereof
CN109790221B (en) * 2016-07-29 2023-12-26 动量制药公司 FcRN antibodies and methods of use thereof
RU2020100880A (en) * 2017-06-15 2021-07-15 Юсб Биофарма Срл METHOD FOR TREATMENT OF IMMUNE THROMBOCYTOPENIA
KR20200098604A (en) 2017-12-13 2020-08-20 모멘타 파머슈티컬스 인코포레이티드 FcRn antibodies and methods of use thereof
MX2020013195A (en) 2018-06-08 2021-02-26 Argenx Bvba Compositions and methods for treating immune thrombocytopenia.
JOP20210014A1 (en) * 2018-07-20 2021-01-19 Zhongli Zhang Compositions of fcrn antibodies and methods of use thereof
WO2020018910A1 (en) * 2018-07-20 2020-01-23 Momenta Pharmaceuticals, Inc. Fcrn antibody compositions
US20220144941A1 (en) 2018-10-16 2022-05-12 UCB Biopharma SRL Method for the treatment of myasthenia gravis
JP7565951B2 (en) 2019-06-07 2024-10-11 アルジェニクス ビーブイ Pharmaceutical formulations of FcRn inhibitors suitable for subcutaneous administration
MX2022001380A (en) * 2019-08-01 2022-03-25 Momenta Pharmaceuticals Inc Fcrn antibodies and methods of use thereof.
IL292889A (en) * 2019-11-19 2022-07-01 Immunovant Sciences Gmbh Methods of treating warm autoimmune hemolytic anemia using anti-fcrn antibodies
MX2023005313A (en) * 2020-11-06 2023-07-11 Momenta Pharmaceuticals Inc Fcrn antibodies and methods of use thereof.
EP4287828A1 (en) * 2021-02-02 2023-12-13 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric fcrn
CN116234827A (en) * 2021-09-03 2023-06-06 舒泰神(北京)生物制药股份有限公司 Antibodies specifically recognizing FcRn and uses thereof
AU2023281650A1 (en) 2022-05-30 2024-10-17 Hanall Biopharma Co., Ltd. Anti-fcrn antibody or antigen binding fragment thereof with improved stability
WO2024163894A1 (en) 2023-02-04 2024-08-08 Momenta Pharmaceuticals, Inc. Compositions and methods for treating hemolytic disease of the fetus and newborn

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EP1660128A4 (en) * 2003-08-08 2009-01-21 Univ New York State Res Found Anti-fcrn antibodies for treatment of auto/allo immune conditions
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NZ589451A (en) * 2008-04-25 2012-07-27 Dyax Corp Antibodies against fcrn and use thereof
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CN109790221B (en) 2016-07-29 2023-12-26 动量制药公司 FcRN antibodies and methods of use thereof
WO2019110823A1 (en) 2017-12-08 2019-06-13 Argenx Bvba Use of fcrn antagonists for treatment of generalized myasthenia gravis
KR20200098604A (en) 2017-12-13 2020-08-20 모멘타 파머슈티컬스 인코포레이티드 FcRn antibodies and methods of use thereof
JOP20210014A1 (en) 2018-07-20 2021-01-19 Zhongli Zhang Compositions of fcrn antibodies and methods of use thereof
WO2020018910A1 (en) 2018-07-20 2020-01-23 Momenta Pharmaceuticals, Inc. Fcrn antibody compositions

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Publication number Publication date
CN118667011A (en) 2024-09-20
CN107567460A (en) 2018-01-09
FI3250610T3 (en) 2023-11-01
US10676526B2 (en) 2020-06-09
WO2016123521A3 (en) 2016-09-22
WO2016123521A2 (en) 2016-08-04
IL252837B (en) 2021-10-31
PT3250610T (en) 2023-11-13
BR112017015287A2 (en) 2018-01-16
AU2022201145A1 (en) 2022-03-17
EP3250610A2 (en) 2017-12-06
JP7224382B2 (en) 2023-02-17
KR20170109020A (en) 2017-09-27
HRP20231399T1 (en) 2024-02-16
JP2021061854A (en) 2021-04-22
NZ733097A (en) 2024-07-05
CA2972822A1 (en) 2016-08-04
RS64768B1 (en) 2023-11-30
CN118667015A (en) 2024-09-20
CN118638229A (en) 2024-09-13
AU2016211280A1 (en) 2017-07-13
US20200299382A1 (en) 2020-09-24
US20180016334A1 (en) 2018-01-18
US20240158508A1 (en) 2024-05-16
SG10202007232WA (en) 2020-09-29
EP4286011A2 (en) 2023-12-06
IL252837A0 (en) 2017-08-31
LT3250610T (en) 2023-09-25
KR102483016B1 (en) 2023-01-03
JP6853178B2 (en) 2021-03-31
DK3250610T3 (en) 2023-10-30
EP3250610B1 (en) 2023-08-09
CN118667014A (en) 2024-09-20
CN118667013A (en) 2024-09-20
EP3250610A4 (en) 2018-08-22
KR20230007545A (en) 2023-01-12
ES2962824T3 (en) 2024-03-21
US11732047B2 (en) 2023-08-22
CN118638230A (en) 2024-09-13
EP4286011A3 (en) 2024-02-14
HUE063778T2 (en) 2024-01-28
JP2018504907A (en) 2018-02-22
PL3250610T3 (en) 2024-01-29
CN118667012A (en) 2024-09-20
CN107567460B (en) 2021-04-23
CN118667009A (en) 2024-09-20
AU2016211280B2 (en) 2021-11-25
SI3250610T1 (en) 2023-11-30
CN113384693A (en) 2021-09-14
CN118562003A (en) 2024-08-30
CN118652337A (en) 2024-09-17
CN118667010A (en) 2024-09-20

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