SG11201507346PA - 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer - Google Patents
3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancerInfo
- Publication number
- SG11201507346PA SG11201507346PA SG11201507346PA SG11201507346PA SG11201507346PA SG 11201507346P A SG11201507346P A SG 11201507346PA SG 11201507346P A SG11201507346P A SG 11201507346PA SG 11201507346P A SG11201507346P A SG 11201507346PA SG 11201507346P A SG11201507346P A SG 11201507346PA
- Authority
- SG
- Singapore
- Prior art keywords
- cancer
- methyleneindolin
- heteroaryl
- inhibitors
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361780248P | 2013-03-13 | 2013-03-13 | |
| US201361780263P | 2013-03-13 | 2013-03-13 | |
| PCT/US2014/026498 WO2014160401A1 (en) | 2013-03-13 | 2014-03-13 | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201507346PA true SG11201507346PA (en) | 2015-10-29 |
Family
ID=50639949
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507346PA SG11201507346PA (en) | 2013-03-13 | 2014-03-13 | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
| SG10201806965XA SG10201806965XA (en) | 2013-03-13 | 2014-03-13 | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201806965XA SG10201806965XA (en) | 2013-03-13 | 2014-03-13 | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20160031888A1 (en) |
| EP (1) | EP2970206A1 (en) |
| JP (2) | JP6378308B2 (en) |
| KR (1) | KR20150127249A (en) |
| CN (1) | CN105408320B (en) |
| AU (2) | AU2014243869A1 (en) |
| BR (1) | BR112015022431A2 (en) |
| CA (1) | CA2904152A1 (en) |
| HK (1) | HK1220184A1 (en) |
| IL (1) | IL240960A0 (en) |
| MX (1) | MX2015011456A (en) |
| RU (2) | RU2019104092A (en) |
| SG (2) | SG11201507346PA (en) |
| WO (1) | WO2014160401A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104876928B (en) * | 2015-05-07 | 2016-09-14 | 浙江司太立制药股份有限公司 | 7-azaindole quinoline-2-ketone compounds and preparation method thereof |
| JPWO2017026119A1 (en) * | 2015-08-10 | 2018-05-24 | 大日本住友製薬株式会社 | Method for purifying 5- (thiazol-4-yl) indoline-2-one derivatives |
| EP3363799A4 (en) * | 2015-11-12 | 2018-12-05 | LG Chem, Ltd. | Pharmaceutical composition containing, as active ingredient, 7-azaindolin-2-one derivative or pharmaceutically acceptable salt thereof |
| CN105461705B (en) * | 2015-11-30 | 2018-04-10 | 中国医科大学 | Dibenzazepine Zhuo diketone anti-tumor compounds and preparation method thereof |
| WO2018005444A2 (en) | 2016-06-28 | 2018-01-04 | Boston Biomedical, Inc. | Methods for treating cancer |
| CN107698593A (en) * | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | Heterocyclic compound as FGFR inhibitor |
| CN106432228A (en) * | 2016-09-06 | 2017-02-22 | 浙江司太立制药股份有限公司 | 4-oximido-1-piperidyl fragment containing 7-azaindolin-2-one compound and preparation method therefor |
| CN106397436A (en) * | 2016-09-06 | 2017-02-15 | 浙江司太立制药股份有限公司 | 5-bromo-7-azaindoline-2-one compounds and preparation method thereof |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| EP3644977A1 (en) | 2017-06-30 | 2020-05-06 | Industrial Technology Research Institute | Method for treating an autoimmune neurological disease and/or neurodegenerative disease and pharmaceutical formulations for a liquid dosage form and a controlled release dosage form |
| CN110357878B (en) * | 2018-03-26 | 2022-04-12 | 武汉誉祥医药科技有限公司 | 1, 3-dihydro-2H-pyrrolo [3,2-b ] pyridin-2-one derivatives and medical use thereof |
| PL3781561T3 (en) | 2018-04-18 | 2024-07-22 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| CN117224541A (en) * | 2018-09-18 | 2023-12-15 | 北京强新生物科技有限公司 | Treatment of obesity |
| EP3852753A4 (en) * | 2018-09-18 | 2022-06-08 | 1Globe Biomedical Co., Ltd. | Treatment for non-alcoholic fatty liver disease |
| EP4157858A4 (en) * | 2020-05-29 | 2024-08-28 | Univ Michigan Regents | Small molecule inhibitors of grk5 and grk5 subfamily members and uses thereof |
| CN111675647B (en) * | 2020-06-26 | 2022-03-01 | 深圳技术大学 | 2-indolone PAK1 inhibitor and application thereof in antitumor drugs |
| JP2023532946A (en) * | 2020-07-10 | 2023-08-01 | ブロッサムヒル・セラピューティクス・インコーポレイテッド | Macrocycles and their uses |
| AU2023204770A1 (en) * | 2022-01-05 | 2024-07-18 | Blossomhill Therapeutics, Inc. | Macrocyclic compounds and use as kinase inhibitors |
| CN114213396B (en) * | 2022-01-27 | 2023-03-24 | 深圳市乐土生物医药有限公司 | Indole-2-ketone compound and preparation method and application thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE640616A (en) | 1962-12-19 | |||
| US3492397A (en) | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| AU7284096A (en) * | 1995-10-09 | 1997-04-30 | Dieter Binder | Heterocyclically-substituted 1-indole carboxamides as cyclo-oxygenase-2 inhibitors |
| GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| TR200101858T2 (en) * | 1998-12-17 | 2001-12-21 | F.Hoffmann-La Roche Ag | 4-aryloxindoles as JNK protein kinase inhibitors |
| WO2001046196A1 (en) * | 1999-12-21 | 2001-06-28 | Sugen, Inc. | 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors |
| CN1329390C (en) * | 2000-02-15 | 2007-08-01 | 苏根公司 | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| JP2004502686A (en) * | 2000-06-30 | 2004-01-29 | スージェン・インコーポレーテッド | 4-Heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors |
| PE20020776A1 (en) * | 2000-12-20 | 2002-08-22 | Sugen Inc | INDOLINONES 4-ARIL SUBSTITUTED |
| AR038957A1 (en) * | 2001-08-15 | 2005-02-02 | Pharmacia Corp | COMBINATION THERAPY FOR CANCER TREATMENT |
| KR20060123184A (en) * | 2003-10-24 | 2006-12-01 | 쉐링 악티엔게젤샤프트 | Indolinone derivatives and their use in treating disease-states such as cancer |
| JP2008524165A (en) * | 2004-12-17 | 2008-07-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Indolinone and its use as an antiproliferative agent |
| US20070032555A1 (en) | 2005-07-01 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel aryloxyphenyl-propanamines |
| WO2007005644A2 (en) | 2005-07-01 | 2007-01-11 | Concert Pharmaceuticals Inc. | Novel aryloxypropanamines |
| CA2616383C (en) | 2005-07-29 | 2015-06-09 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| KR20080047375A (en) | 2005-07-29 | 2008-05-28 | 콘서트 파마슈티컬즈, 인크. | Novel pharmaceutical compounds |
| US7514566B2 (en) * | 2006-01-18 | 2009-04-07 | Amgen, Inc. | Thiazole compounds and methods of use |
| CN101007801A (en) * | 2006-01-27 | 2007-08-01 | 上海恒瑞医药有限公司 | Pyrrole substituted 2-dihydromolindone derivative, its preparation method and medical uses |
| BRPI0717805A2 (en) * | 2006-10-06 | 2013-10-29 | Irm Llc | PROTEIN KINASE INHIBITORS AND METHODS OF USE |
| US8299106B2 (en) * | 2007-09-06 | 2012-10-30 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
| EP2300469B1 (en) * | 2008-05-13 | 2015-06-24 | Novartis AG | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors |
| EP2471787A1 (en) * | 2008-07-29 | 2012-07-04 | Boehringer Ingelheim International GmbH | New compounds |
| US9227962B2 (en) * | 2013-03-13 | 2016-01-05 | Boston Biomedical, Inc. | Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative |
| US9187454B2 (en) * | 2013-03-13 | 2015-11-17 | Boston Biomedical, Inc. | Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof |
| WO2015112941A1 (en) * | 2014-01-27 | 2015-07-30 | Boston Biomedical, Inc. | Novel methods for treating cancer |
-
2014
- 2014-03-13 SG SG11201507346PA patent/SG11201507346PA/en unknown
- 2014-03-13 RU RU2019104092A patent/RU2019104092A/en unknown
- 2014-03-13 MX MX2015011456A patent/MX2015011456A/en unknown
- 2014-03-13 KR KR1020157028817A patent/KR20150127249A/en not_active Application Discontinuation
- 2014-03-13 US US14/774,803 patent/US20160031888A1/en not_active Abandoned
- 2014-03-13 SG SG10201806965XA patent/SG10201806965XA/en unknown
- 2014-03-13 WO PCT/US2014/026498 patent/WO2014160401A1/en active Application Filing
- 2014-03-13 BR BR112015022431A patent/BR112015022431A2/en not_active Application Discontinuation
- 2014-03-13 RU RU2015143526A patent/RU2015143526A/en not_active Application Discontinuation
- 2014-03-13 AU AU2014243869A patent/AU2014243869A1/en not_active Abandoned
- 2014-03-13 JP JP2016502156A patent/JP6378308B2/en not_active Expired - Fee Related
- 2014-03-13 CN CN201480026333.XA patent/CN105408320B/en active Active
- 2014-03-13 EP EP14721620.4A patent/EP2970206A1/en not_active Withdrawn
- 2014-03-13 CA CA2904152A patent/CA2904152A1/en not_active Abandoned
-
2015
- 2015-08-31 IL IL240960A patent/IL240960A0/en unknown
-
2016
- 2016-07-12 HK HK16108180.5A patent/HK1220184A1/en unknown
-
2018
- 2018-07-06 JP JP2018129002A patent/JP2018168187A/en active Pending
- 2018-09-21 AU AU2018233033A patent/AU2018233033A1/en not_active Abandoned
- 2018-11-30 US US16/206,010 patent/US20190241569A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN105408320A (en) | 2016-03-16 |
| MX2015011456A (en) | 2016-05-31 |
| EP2970206A1 (en) | 2016-01-20 |
| JP2016513656A (en) | 2016-05-16 |
| BR112015022431A2 (en) | 2017-05-09 |
| HK1220184A1 (en) | 2017-04-28 |
| US20190241569A1 (en) | 2019-08-08 |
| US20160031888A1 (en) | 2016-02-04 |
| CN105408320B (en) | 2019-08-13 |
| IL240960A0 (en) | 2015-11-30 |
| JP6378308B2 (en) | 2018-08-22 |
| AU2018233033A1 (en) | 2018-10-11 |
| SG10201806965XA (en) | 2018-09-27 |
| RU2015143526A (en) | 2017-04-19 |
| AU2014243869A1 (en) | 2015-09-24 |
| RU2019104092A (en) | 2019-03-20 |
| JP2018168187A (en) | 2018-11-01 |
| WO2014160401A1 (en) | 2014-10-02 |
| KR20150127249A (en) | 2015-11-16 |
| CA2904152A1 (en) | 2014-10-02 |
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