SG11201407370QA - Humanized il-7 rodents - Google Patents
Humanized il-7 rodentsInfo
- Publication number
- SG11201407370QA SG11201407370QA SG11201407370QA SG11201407370QA SG11201407370QA SG 11201407370Q A SG11201407370Q A SG 11201407370QA SG 11201407370Q A SG11201407370Q A SG 11201407370QA SG 11201407370Q A SG11201407370Q A SG 11201407370QA SG 11201407370Q A SG11201407370Q A SG 11201407370QA
- Authority
- SG
- Singapore
- Prior art keywords
- human
- international
- humanized
- gene
- rodents
- Prior art date
Links
- 241000283984 Rodentia Species 0.000 title abstract 3
- 108010002586 Interleukin-7 Proteins 0.000 abstract 5
- 102000000704 Interleukin-7 Human genes 0.000 abstract 4
- 229940100994 interleukin-7 Drugs 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 101001043808 Mus musculus Interleukin-7 Proteins 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000004602 germ cell Anatomy 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0387—Animal model for diseases of the immune system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Catching Or Destruction (AREA)
Abstract
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2013 (27.12.2013) WIPOIPCT (10) International Publication Number WO 2013/192030 A1 (51) International Patent Classification: A01K 67/027 ( 2006.01) C07K14/54 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/045788 14 June 2013 (14.06.2013) English English (30) Priority Data: 61/660,976 18 June 2012 (18.06.2012) US 61/740,074 20 December 2012 (20.12.2012) US 13/795,765 12 March 2013 (12.03.2013) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). (72) Inventor: MURPHY, Andrew J.; 10 Newton Court, Cro- ton-on-Hudson, New York 10520 (US). (74) Agents: POBURSKY, Kevin J. et al.; Choate, Hall & Stewart LLP, Two International Place, Boston, Massachu setts 021 10 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) © o CJ o\ i-H o CJ (54) Title: HUMANIZED IL-7 RODENTS (57) Abstract: Genetically modified non-human animals comprising human a or humanized interleukin-7 (IL-7) gene. Cells, embry os, and non-human animals comprising human a or humanized IL-7 gene. Rodents that express human or humanized IL-7 protein. Genetically modified mice that comprise human a or humanized IL-7-encoding gene in their germline, wherein the human human or - ized IL-7-encoding gene is under control of endogenous mouse IL-7 regulatory sequences.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660976P | 2012-06-18 | 2012-06-18 | |
| US201261740074P | 2012-12-20 | 2012-12-20 | |
| US13/795,765 US8962913B2 (en) | 2012-06-18 | 2013-03-12 | Humanized IL-7 rodents |
| PCT/US2013/045788 WO2013192030A1 (en) | 2012-06-18 | 2013-06-14 | Humanized il-7 rodents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201407370QA true SG11201407370QA (en) | 2014-12-30 |
Family
ID=49757275
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201609569PA SG10201609569PA (en) | 2012-06-18 | 2013-06-14 | Humanized il-7 rodents |
| SG10201609576YA SG10201609576YA (en) | 2012-06-18 | 2013-06-14 | Humanized il-7 rodents |
| SG11201407370QA SG11201407370QA (en) | 2012-06-18 | 2013-06-14 | Humanized il-7 rodents |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201609569PA SG10201609569PA (en) | 2012-06-18 | 2013-06-14 | Humanized il-7 rodents |
| SG10201609576YA SG10201609576YA (en) | 2012-06-18 | 2013-06-14 | Humanized il-7 rodents |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US8962913B2 (en) |
| EP (2) | EP2861063A1 (en) |
| JP (1) | JP6174134B2 (en) |
| KR (1) | KR20150027752A (en) |
| CN (2) | CN105779467A (en) |
| AU (1) | AU2013277457B2 (en) |
| BR (1) | BR112014029892A2 (en) |
| CA (1) | CA2873134A1 (en) |
| CY (1) | CY1119071T1 (en) |
| DK (1) | DK2859793T3 (en) |
| ES (1) | ES2626965T3 (en) |
| HK (2) | HK1203302A1 (en) |
| HR (1) | HRP20170974T1 (en) |
| HU (1) | HUE034592T2 (en) |
| IL (3) | IL235773B (en) |
| IN (1) | IN2014DN10189A (en) |
| LT (1) | LT2859793T (en) |
| MX (1) | MX363540B (en) |
| NZ (1) | NZ702943A (en) |
| PL (1) | PL2859793T3 (en) |
| PT (1) | PT2859793T (en) |
| RS (1) | RS56039B1 (en) |
| RU (1) | RU2654565C2 (en) |
| SG (3) | SG10201609569PA (en) |
| SI (1) | SI2859793T1 (en) |
| WO (1) | WO2013192030A1 (en) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2792236B2 (en) | 2009-07-08 | 2023-03-22 | Kymab Limited | Animal models and therapeutic molecules |
| ES2612935T3 (en) | 2011-09-19 | 2017-05-19 | Kymab Limited | Antibodies, variable domains and chains adapted for use in humans |
| EP2637344B1 (en) * | 2012-03-05 | 2022-01-12 | Samsung Electronics Co., Ltd. | HARQ-ACK signal transmission in response to detection of control channel type in case of multiple control channel types |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| US8962913B2 (en) * | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| DK2922394T3 (en) | 2013-09-23 | 2017-05-15 | Regeneron Pharma | Non-human animals with a humanized signal regulatory protein gene |
| EP3794941B1 (en) | 2013-10-01 | 2024-09-25 | Kymab Limited | Animal models and therapeutic molecules |
| RS58465B1 (en) | 2013-10-15 | 2019-04-30 | Regeneron Pharma | Humanized il-15 animals |
| RU2713327C2 (en) | 2014-05-05 | 2020-02-04 | Регенерон Фармасьютикалз, Инк. | Humanised animals by c5 and c3 |
| NO2785538T3 (en) | 2014-05-07 | 2018-08-04 | ||
| KR102313073B1 (en) | 2014-12-05 | 2021-10-18 | 리제너론 파마슈티칼스 인코포레이티드 | Non-human animals having a humanized cluster of differentiation 47 gene |
| IL302370A (en) * | 2015-04-13 | 2023-06-01 | Regeneron Pharma | Humanized sirpa-il15 knockin mice and methods of use thereof |
| SG11201806176PA (en) | 2016-02-04 | 2018-08-30 | Regeneron Pharma | Non-human animals having an engineered angptl8 gene |
| EP3422845B1 (en) | 2016-02-29 | 2021-06-02 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| EP4276185A3 (en) | 2017-09-29 | 2024-02-21 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized ttr locus and methods of use |
| ES2983967T3 (en) | 2018-07-16 | 2024-10-28 | Regeneron Pharma | Rodent models of DITRA disease and their uses |
| CN114164177A (en) * | 2019-01-17 | 2022-03-11 | 百奥赛图(北京)医药科技股份有限公司 | Humanized transgenic animal |
| ES2966625T3 (en) | 2019-04-04 | 2024-04-23 | Regeneron Pharma | Rodents comprising a humanized coagulation factor 12 locus |
| CN113874510A (en) | 2019-06-04 | 2021-12-31 | 瑞泽恩制药公司 | Non-human animals including humanized TTR loci with beta glide mutations and methods of use |
| EP3796776A1 (en) | 2019-06-07 | 2021-03-31 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized albumin locus |
| WO2021027737A1 (en) * | 2019-08-09 | 2021-02-18 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric il2ra |
| JP2023511626A (en) * | 2020-01-28 | 2023-03-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Non-human animals containing a humanized PNPLA3 locus and methods of use |
| KR102316506B1 (en) | 2020-02-26 | 2021-10-22 | 차의과학대학교 산학협력단 | A method for promoting humanized activity of animal immune system |
| CN111926039B (en) * | 2020-09-23 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Construction method and application of IL-13 gene humanized non-human animal |
| KR20230124973A (en) * | 2020-12-21 | 2023-08-28 | 리제너론 파마슈티칼스 인코포레이티드 | Non-human animals having a humanized TSLP gene, a humanized TSLP receptor gene, and/or a humanized IL7RA gene |
| CN114835798B (en) * | 2021-05-28 | 2024-02-23 | 百奥赛图(北京)医药科技股份有限公司 | Construction method and application of CD36 gene humanized non-human animal |
| WO2024054904A1 (en) * | 2022-09-08 | 2024-03-14 | The Jackson Laboratory | Humanized immunodeficient mouse models |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA887773B (en) * | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
| WO2001015521A1 (en) | 1999-08-31 | 2001-03-08 | Genencor International, Inc. | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
| US7759541B2 (en) | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| GB2434578A (en) | 2006-01-26 | 2007-08-01 | Univ Basel | Transgenic animals |
| CN101302517B (en) * | 2008-02-03 | 2010-11-03 | 中国科学院广州生物医药与健康研究院 | Expressing method of human interleukin 7 in eucaryon host |
| EP4049535A1 (en) * | 2009-10-06 | 2022-08-31 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| PT2675271T (en) | 2011-02-15 | 2018-10-11 | Univ Yale | Humanized m-csf mice |
| SI2663575T1 (en) | 2011-10-28 | 2015-01-30 | Regeneron Pharmaceuticals, Inc. | Humanized il-6 and il-6 receptor |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
-
2013
- 2013-03-12 US US13/795,765 patent/US8962913B2/en not_active Expired - Fee Related
- 2013-06-14 LT LTEP14195502.1T patent/LT2859793T/en unknown
- 2013-06-14 PT PT141955021T patent/PT2859793T/en unknown
- 2013-06-14 CN CN201610168011.XA patent/CN105779467A/en active Pending
- 2013-06-14 EP EP13739875.6A patent/EP2861063A1/en not_active Withdrawn
- 2013-06-14 RU RU2014148107A patent/RU2654565C2/en not_active IP Right Cessation
- 2013-06-14 JP JP2015517447A patent/JP6174134B2/en not_active Expired - Fee Related
- 2013-06-14 AU AU2013277457A patent/AU2013277457B2/en not_active Ceased
- 2013-06-14 WO PCT/US2013/045788 patent/WO2013192030A1/en active Application Filing
- 2013-06-14 CA CA2873134A patent/CA2873134A1/en not_active Abandoned
- 2013-06-14 PL PL14195502T patent/PL2859793T3/en unknown
- 2013-06-14 DK DK14195502.1T patent/DK2859793T3/en active
- 2013-06-14 ES ES14195502.1T patent/ES2626965T3/en active Active
- 2013-06-14 MX MX2014015679A patent/MX363540B/en unknown
- 2013-06-14 BR BR112014029892A patent/BR112014029892A2/en not_active Application Discontinuation
- 2013-06-14 CN CN201380031333.4A patent/CN104378976B/en not_active Expired - Fee Related
- 2013-06-14 EP EP14195502.1A patent/EP2859793B1/en active Active
- 2013-06-14 NZ NZ702943A patent/NZ702943A/en not_active IP Right Cessation
- 2013-06-14 SI SI201330664A patent/SI2859793T1/en unknown
- 2013-06-14 SG SG10201609569PA patent/SG10201609569PA/en unknown
- 2013-06-14 SG SG10201609576YA patent/SG10201609576YA/en unknown
- 2013-06-14 HU HUE14195502A patent/HUE034592T2/en unknown
- 2013-06-14 SG SG11201407370QA patent/SG11201407370QA/en unknown
- 2013-06-14 RS RS20170543A patent/RS56039B1/en unknown
- 2013-06-14 KR KR1020147035047A patent/KR20150027752A/en not_active Application Discontinuation
-
2014
- 2014-11-18 IL IL235773A patent/IL235773B/en active IP Right Grant
- 2014-11-24 US US14/551,538 patent/US9232776B2/en not_active Expired - Fee Related
- 2014-11-28 IN IN10189DEN2014 patent/IN2014DN10189A/en unknown
-
2015
- 2015-04-20 HK HK15103801.6A patent/HK1203302A1/en not_active IP Right Cessation
- 2015-05-06 HK HK15104315.3A patent/HK1203761A1/en unknown
- 2015-11-10 US US14/937,270 patent/US20160052986A1/en not_active Abandoned
-
2016
- 2016-11-21 US US15/357,021 patent/US9737059B2/en not_active Expired - Fee Related
-
2017
- 2017-05-31 CY CY20171100577T patent/CY1119071T1/en unknown
- 2017-06-27 HR HRP20170974TT patent/HRP20170974T1/en unknown
- 2017-07-14 US US15/649,797 patent/US9974291B2/en not_active Expired - Fee Related
-
2018
- 2018-04-24 US US15/960,642 patent/US10314298B2/en not_active Expired - Fee Related
- 2018-06-25 IL IL260250A patent/IL260250B/en not_active IP Right Cessation
-
2019
- 2019-05-01 US US16/400,074 patent/US20190343093A1/en not_active Abandoned
- 2019-08-13 IL IL26867419A patent/IL268674A/en unknown
Also Published As
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|---|---|---|
| SG11201407370QA (en) | Humanized il-7 rodents | |
| SG11201407789RA (en) | Humanized non-human animals with restricted immunoglobulin heavy chain loci | |
| SG11201804161VA (en) | Compositions comprising bacterial strains | |
| SG11201804162WA (en) | Compositions comprising bacterial strains | |
| SG11201804118VA (en) | Compositions comprising bacterial strains | |
| SG11201804211YA (en) | Compositions comprising bacterial strains | |
| SG11201407486PA (en) | Compositions and methods for modulating utrn expression | |
| SG11201407669QA (en) | Methods for improving safety of blood-brain barrier transport | |
| SG11201807279QA (en) | Binding proteins and methods of use thereof | |
| SG11201804375WA (en) | Compositions and methods for internalizing enzymes | |
| SG11201907867TA (en) | Use of anti-ctla-4 antibodies with enhanced adcc to enhance immune response to a vaccine | |
| SG11201408780XA (en) | Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof | |
| SG11201803905RA (en) | A hair styling appliance | |
| SG11201805157TA (en) | Targeted disruption of the mhc cell receptor | |
| SG11201403106SA (en) | Anti-phf-tau antibodies and their uses | |
| SG11201909203WA (en) | Tissue selective transgene expression | |
| SG11201407580YA (en) | Composition comprising two antibodies engineered to have reduced and increased effector function | |
| SG11201408051VA (en) | Cho expression system | |
| SG11201803703UA (en) | Anti-complement factor c1q fab fragments and uses thereof | |
| SG11201407381VA (en) | System and methods for coping with doppler effects in distributed-input distributed-output wireless systems | |
| SG11201408002TA (en) | Multi-parameter diabetes risk evaluations | |
| SG11201407644UA (en) | Methods for making fully human bispecific antibodies using a common light chain | |
| SG11201407655TA (en) | Therapeutic uses of fibroblast growth factor 21 proteins | |
| SG11201406903SA (en) | Cell culture compositions and methods for polypeptide production | |
| SG11201407702XA (en) | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |