SG11201401043SA - P53 activating peptides - Google Patents
P53 activating peptidesInfo
- Publication number
- SG11201401043SA SG11201401043SA SG11201401043SA SG11201401043SA SG11201401043SA SG 11201401043S A SG11201401043S A SG 11201401043SA SG 11201401043S A SG11201401043S A SG 11201401043SA SG 11201401043S A SG11201401043S A SG 11201401043SA SG 11201401043S A SG11201401043S A SG 11201401043SA
- Authority
- SG
- Singapore
- Prior art keywords
- activating peptides
- peptides
- activating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Ecology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG11201401043SA SG11201401043SA (en) | 2011-09-09 | 2012-09-10 | P53 activating peptides |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG2011065901 | 2011-09-09 | ||
| PCT/SG2012/000329 WO2013036208A1 (en) | 2011-09-09 | 2012-09-10 | P53 activating peptides |
| SG11201401043SA SG11201401043SA (en) | 2011-09-09 | 2012-09-10 | P53 activating peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201401043SA true SG11201401043SA (en) | 2014-08-28 |
Family
ID=54259020
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201401043SA SG11201401043SA (en) | 2011-09-09 | 2012-09-10 | P53 activating peptides |
| SG10201601840RA SG10201601840RA (en) | 2011-09-09 | 2012-09-10 | P53 activating peptides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201601840RA SG10201601840RA (en) | 2011-09-09 | 2012-09-10 | P53 activating peptides |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9517252B2 (en) |
| EP (2) | EP3444262A3 (en) |
| SG (2) | SG11201401043SA (en) |
| WO (1) | WO2013036208A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2558928T3 (en) | 2007-01-31 | 2016-02-09 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| KR101525754B1 (en) | 2007-03-28 | 2015-06-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Stitched polypeptides |
| MX355543B (en) | 2010-08-13 | 2018-04-20 | Aileron Therapeutics Inc Star | Peptidomimetic macrocycles. |
| SG11201401043SA (en) | 2011-09-09 | 2014-08-28 | Agency Science Tech & Res | P53 activating peptides |
| KR20140100937A (en) | 2011-10-18 | 2014-08-18 | 에일러론 테라퓨틱스 인코포레이티드 | Peptidomimetic macrocycles |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| WO2013123266A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| US9604919B2 (en) | 2012-11-01 | 2017-03-28 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| CN105636977A (en) * | 2013-05-08 | 2016-06-01 | 加利福尼亚大学董事会 | Structure-based peptide inhibitors of p53 aggregation as a new approach to cancer therapeutics |
| RU2693487C2 (en) | 2013-08-07 | 2019-07-03 | Йеда Ресеарч Энд Девелопмент Ко. Лтд. | Peptides capable of reactivating p53 mutants |
| WO2015145432A2 (en) * | 2014-03-24 | 2015-10-01 | Yeda Research And Development Co. Ltd. | Stabilization of mutant p53 in wild type conformation by proteins of embryonic stem cells |
| BR112017005736A2 (en) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | peptidomimetic macrocycles and formulations thereof |
| CN112245565A (en) | 2014-09-24 | 2021-01-22 | 艾瑞朗医疗公司 | Peptidomimetic macrocycles and uses thereof |
| BR112017019738A2 (en) | 2015-03-20 | 2018-05-29 | Aileron Therapeutics Inc | peptidomimetic macrocycles and their uses |
| EP3347372A4 (en) | 2015-09-10 | 2019-09-04 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
| EP3411390A1 (en) * | 2016-02-04 | 2018-12-12 | Yeda Research and Development Co. Ltd | Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53 |
| MX2018009947A (en) * | 2016-02-19 | 2019-01-21 | Pmv Pharmaceuticals Inc | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION. |
| GB201617564D0 (en) | 2016-10-17 | 2016-11-30 | Agency For Science Technology And Research And National University Of Singapore And Singapore Health | Anti-p53 antibodies |
| JP2021506814A (en) | 2017-12-15 | 2021-02-22 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Degradation of target proteins mediated by stabilizing peptides |
| EP3749678A1 (en) | 2018-02-07 | 2020-12-16 | Dana Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| WO2020023502A1 (en) | 2018-07-23 | 2020-01-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| BR112022005460A2 (en) | 2019-09-23 | 2022-08-16 | Pmv Pharmaceuticals Inc | METHODS AND COMPOUNDS FOR THE RESTORATION OF MUTANT P53 FUNCTION |
| WO2021207598A1 (en) * | 2020-04-10 | 2021-10-14 | Aprea Therapeutics, Inc. | Combination treatment with an agonist of p53 and a second therapeutic agent |
| JP2023533447A (en) | 2020-06-24 | 2023-08-03 | ピーエムブイ ファーマシューティカルズ， インコーポレイテッド | Combination therapies to treat cancer |
| CA3193261A1 (en) | 2020-10-14 | 2022-04-21 | Dana-Farber Cancer Institute, Inc. | Chimeric conjugates for degradation of viral and host proteins and methods of use |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7611713B2 (en) | 1993-03-05 | 2009-11-03 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide compositions |
| AU7238098A (en) | 1997-05-15 | 1998-12-08 | Kyowa Hakko Kogyo Co. Ltd. | Peptides having cyclic structures and exerting p53 protein activty-restoring effect on p53 protein mutants |
| CA2323632A1 (en) * | 1998-03-13 | 1999-09-16 | Epimmune Inc. | Hla-binding peptides and their uses |
| US20100293663A2 (en) | 1998-06-16 | 2010-11-18 | Thomas La Rosa | Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
| US20090087878A9 (en) | 1999-05-06 | 2009-04-02 | La Rosa Thomas J | Nucleic acid molecules associated with plants |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| WO2001092523A2 (en) | 2000-05-30 | 2001-12-06 | Curagen Corporation | Human polynucleotides and polypeptides encoded thereby |
| EP2197908A2 (en) | 2007-09-27 | 2010-06-23 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
| US20110214205A1 (en) | 2010-02-26 | 2011-09-01 | Monsanto Technology Llc. | Isolated Novel Nucleic Acid and Protein Molecules from Foxtail Millet and Methods of Using Those Molecules to Generate Transgenic Plants with Enhanced Agronomic Traits |
| SG11201401043SA (en) | 2011-09-09 | 2014-08-28 | Agency Science Tech & Res | P53 activating peptides |
-
2012
- 2012-09-10 SG SG11201401043SA patent/SG11201401043SA/en unknown
- 2012-09-10 EP EP18183238.7A patent/EP3444262A3/en not_active Withdrawn
- 2012-09-10 US US14/350,390 patent/US9517252B2/en active Active
- 2012-09-10 WO PCT/SG2012/000329 patent/WO2013036208A1/en active Application Filing
- 2012-09-10 EP EP12829288.5A patent/EP2753635A4/en not_active Withdrawn
- 2012-09-10 SG SG10201601840RA patent/SG10201601840RA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG10201601840RA (en) | 2016-04-28 |
| EP3444262A3 (en) | 2019-04-10 |
| EP2753635A4 (en) | 2015-08-12 |
| US9517252B2 (en) | 2016-12-13 |
| EP2753635A1 (en) | 2014-07-16 |
| EP3444262A2 (en) | 2019-02-20 |
| WO2013036208A1 (en) | 2013-03-14 |
| US20150359843A1 (en) | 2015-12-17 |
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