SG10202105768WA - Colonic organoids and methods of making and using same - Google Patents

Colonic organoids and methods of making and using same

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Publication number
SG10202105768WA
SG10202105768WA SG10202105768WA SG10202105768WA SG10202105768WA SG 10202105768W A SG10202105768W A SG 10202105768WA SG 10202105768W A SG10202105768W A SG 10202105768WA SG 10202105768W A SG10202105768W A SG 10202105768WA SG 10202105768W A SG10202105768W A SG 10202105768WA
Authority
SG
Singapore
Prior art keywords
making
methods
same
colonic organoids
organoids
Prior art date
Application number
SG10202105768WA
Inventor
James Wells
Jorge Munera
Original Assignee
Childrens Hospital Med Ct
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Childrens Hospital Med Ct filed Critical Childrens Hospital Med Ct
Publication of SG10202105768WA publication Critical patent/SG10202105768WA/en

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • GPHYSICS
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/90Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
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  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10202105768WA 2016-12-05 2017-12-05 Colonic organoids and methods of making and using same SG10202105768WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662429948P 2016-12-05 2016-12-05
US201762478962P 2017-03-30 2017-03-30

Publications (1)

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SG10202105768WA true SG10202105768WA (en) 2021-06-29

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US (2) US11767515B2 (en)
EP (1) EP3548507A4 (en)
JP (3) JP7068305B2 (en)
KR (2) KR102558606B1 (en)
CN (2) CN118909916A (en)
AU (3) AU2017373767B2 (en)
CA (1) CA3045145A1 (en)
IL (1) IL267109A (en)
NZ (1) NZ753873A (en)
SG (1) SG10202105768WA (en)
WO (1) WO2018106628A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
JP6963882B2 (en) 2016-05-05 2021-11-10 チルドレンズ ホスピタル メディカル センター Methods for the in vitro production of fundic tissue and compositions associated with such methods.
NZ753873A (en) 2016-12-05 2023-01-27 Children’S Hospital Medical Center Colonic organoids and methods of making and using same
WO2018213773A1 (en) 2017-05-19 2018-11-22 Cedars-Sinai Medical Center Systems and methods for growth of intestinal cells
CN112823012A (en) * 2018-09-12 2021-05-18 儿童医院医学中心 Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
EP3968767A4 (en) * 2019-05-15 2023-07-26 The Cleveland Clinic Foundation Induced human colitic organoids
EP4051782A4 (en) * 2019-10-31 2023-12-06 University Health Network Medium and methods for culturing organoids
CN111849860B (en) * 2020-06-01 2021-12-21 浙江大学 Method for regulating and controlling intestinal stem cell differentiation by using iron element and application
US20230303981A1 (en) * 2020-07-30 2023-09-28 Riken Bladder organoid and method for producing same
CN113009155B (en) * 2021-03-05 2022-03-25 温州医科大学慈溪生物医药研究院 Application of FGF20 in preparation of reagent for diagnosing ulcerative colitis
IL281561A (en) 2021-03-16 2022-10-01 Yeda Res & Dev Methods and devices for ex-utero mouse embryonic development
CN113388572B (en) * 2021-08-17 2021-11-19 天九再生医学(天津)科技有限公司 Method for inducing and differentiating high-efficiency human pluripotent stem cells into multi-lineage small intestine organoids in vitro
CN114107208A (en) * 2021-11-12 2022-03-01 复旦大学附属中山医院 Preparation method of human organoid library
KR20240109474A (en) * 2023-01-04 2024-07-11 연세대학교 산학협력단 Estimation of individual DNA damage response and prediction of the risk of cancer using colon organoids derived from patients with deficiency of DNA mismatch repair function
WO2024192567A1 (en) * 2023-03-17 2024-09-26 北京大学 Novel human intestinal tract and colorectal tumor organoid culture system
CN118240750B (en) * 2024-05-28 2024-08-13 淇嘉科技(苏州)有限公司 Method for constructing colon organoid with immune cells
CN118374446B (en) * 2024-06-26 2024-10-01 淇嘉科技(苏州)有限公司 Batch preparation method of macrophage-containing colon organoids
CN118374432B (en) * 2024-06-26 2024-10-01 淇嘉科技(苏州)有限公司 Method for preparing homogenized intestinal organoids

Family Cites Families (313)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007615A1 (en) 1990-10-29 1992-05-14 Regents Of The University Of Minnesota A bioartificial liver
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5912227A (en) 1995-01-27 1999-06-15 North Carolina State University Method of enhancing nutrient uptake
WO1998021312A1 (en) 1996-11-08 1998-05-22 Rpms Technology Limited Human hepatocytes in three-dimensional support systems
AU748044B2 (en) 1997-01-16 2002-05-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem A device and method for performing a biological modification of a fluid
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
US6647358B2 (en) 1998-09-14 2003-11-11 Lion Bioscience Ag Pharmacokinetic-based drug design tool and method
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US6607501B2 (en) 2001-05-14 2003-08-19 Reynolds G. Gorsuch Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications
US20030129751A1 (en) 2001-05-16 2003-07-10 Grikscheit Tracy C. Tissue-engineered organs
JP4666567B2 (en) 2001-12-07 2011-04-06 ジェロン・コーポレーション Islet cells derived from human embryonic stem cells
US20050170506A1 (en) 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US7160719B2 (en) 2002-06-07 2007-01-09 Mayo Foundation For Medical Education And Research Bioartificial liver system
JP4187167B2 (en) 2002-08-28 2008-11-26 和守 船津 Modified cross-section hollow fiber membrane cell-containing device
TW571101B (en) 2003-01-21 2004-01-11 Ind Tech Res Inst Fluid analysis apparatus
WO2004071573A2 (en) 2003-02-07 2004-08-26 The Johns Hopkins University Hypoxia induced mitogenic factor
WO2004069798A1 (en) 2003-02-10 2004-08-19 Banyu Pharmaceutical Co.,Ltd. Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient
DE10362002B4 (en) 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adult pluripotent stem cells
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
JP4819697B2 (en) 2003-12-23 2011-11-24 ヴィアサイト,インコーポレイテッド Definitive endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
WO2005081970A2 (en) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
DE102004017476B4 (en) 2004-04-08 2009-03-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Process for the preparation of a cell composition containing epithelial cells
JP4926946B2 (en) 2004-04-27 2012-05-09 ヴィアサイト,インコーポレイテッド PDX1-expressing endoderm
JP4650608B2 (en) 2004-05-18 2011-03-16 信越化学工業株式会社 Photomask blank and photomask manufacturing method
US9375514B2 (en) 2004-05-21 2016-06-28 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Multicellular tissue and organ culture systems
AU2005265098B2 (en) 2004-06-17 2012-02-23 Thrasos Innovation, Inc. TDF-related compounds and analogs thereof
WO2006016999A1 (en) 2004-07-09 2006-02-16 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
CA2573512C (en) 2004-07-12 2014-09-23 Emisphere Technologies, Inc. Compositions for delivering peptide yy and pyy agonists
BRPI0512396A (en) 2004-07-21 2008-03-11 Ambrx Inc biosynthetic polypeptides using non-naturally encoded amino acids
MX2007001772A (en) 2004-08-13 2007-07-11 Univ Georgia Res Found Compositions and methods for self-renewal and differentiation in human embryonic stem cells.
US20060236415A1 (en) 2005-03-09 2006-10-19 Silversides David W Neural crest cells specific promoters; isolated neural crest cells; and methods of isolating and of using same
US7604929B2 (en) 2005-04-21 2009-10-20 In Vitro Technologies, Inc. Cellular compositions and methods for their preparation
WO2006122147A2 (en) 2005-05-10 2006-11-16 Rutgers, The State University Of New Jersey Alginate poly-l-lysine encapsulation as a technology for controlled differentiation of embryonic stem cells
WO2006126219A1 (en) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
GB0517382D0 (en) 2005-08-26 2005-10-05 Plasticell Ltd Cell culture
WO2007027905A2 (en) 2005-08-31 2007-03-08 Science And Technology Corporation @ Unm Human renal stem cells
US20070122905A1 (en) 2005-10-27 2007-05-31 D Amour Kevin A PDX1-expressing dorsal and ventral foregut endoderm
US7927869B2 (en) 2005-11-29 2011-04-19 Spencer Z Rosero System and method for supporting a biological chip device
US20070239083A1 (en) 2006-01-18 2007-10-11 Axel Voss Shock wave generators
US20070238169A1 (en) 2006-04-11 2007-10-11 The Board Of Trustees Of The Leland Stanford Junior University Cell sorter and culture system
US8685730B2 (en) 2006-05-02 2014-04-01 Wisconsin Alumni Research Foundation Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
WO2007136707A2 (en) 2006-05-17 2007-11-29 University Of Utah Research Foundation Methods and compositions related to eosinophil regulation
US7932244B2 (en) 2006-06-27 2011-04-26 Intercept Pharmaceuticals, Inc. Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions
CA2658768C (en) 2006-07-21 2016-05-17 Massachusetts Institute Of Technology End-modified poly(beta-amino esters) and uses thereof
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties
WO2008075339A2 (en) 2006-12-18 2008-06-26 Ben Gurion University Of The Negev Scaffolding for tissue regeneration or repair
FR2917425B1 (en) 2007-06-18 2010-11-19 Univ Nancy 1 Henri Poincare METHOD FOR THE PROLIFERATION OF CELLS ON POLYELECTROLYTE MULTILAYERS AND ITS APPLICATION, IN PARTICULAR TO THE PREPARATION OF CELLULARIZED BIOMATERIALS
GB2467645B (en) 2007-07-06 2011-12-21 Univ London A method of proliferating human hepatocyte cells
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
EP2631650B1 (en) * 2007-09-07 2015-04-22 Children's Hospital Medical Center Composition comprising alpha-1,2 fucosyl glycans for treating gastrointestinal disorders
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
CA2708780A1 (en) 2007-12-11 2009-06-18 Research Development Foundation Small molecules for neuronal differentiation of embryonic stem cells
WO2009086596A1 (en) 2008-01-08 2009-07-16 The University Of Queensland Method of producing a population of cells
EP2318031A4 (en) 2008-06-03 2012-09-12 Aethlon Medical Inc Enhanced antiviral therapy methods and devices
SG193829A1 (en) 2008-06-04 2013-10-30 Tissuse Gmbh Organ-on-a-chip-device
JP5624981B2 (en) 2008-06-24 2014-11-12 ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリThe Curators Ofthe University Of Missouri Self-assembling multicellular body and method for producing a three-dimensional biological structure using the multicellular body
ITRM20080342A1 (en) 2008-06-26 2009-12-27 Univ Degli Studi Udine DOLLS-SIMILAR PULP CELLS, INSULATION AND USE METHODS.
US20130115673A1 (en) 2008-07-16 2013-05-09 Biotime, Inc. Methods of Screening Embryonic Progenitor Cell Lines
US20110305672A1 (en) 2008-07-25 2011-12-15 University Of Georgia Research Foundation, Inc. COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
EP2352512A1 (en) 2008-11-05 2011-08-10 Merck Sharp & Dohme Corp. Mechanism of neuromedin u action and uses thereof
JP5351601B2 (en) 2008-12-26 2013-11-27 矢崎総業株式会社 Insulating cap manufacturing method and insulating cap manufacturing apparatus
GB201111244D0 (en) 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
KR101904224B1 (en) 2009-02-03 2018-10-04 코닌클리즈케 네덜란드세 아카데미 반 베텐샤펜 Culture medium for epithelial stem cells and organoids comprising said stem cells
WO2010094694A1 (en) 2009-02-23 2010-08-26 F. Hoffmann-La Roche Ag Assays to predict cardiotoxicity
US10130748B2 (en) 2009-03-13 2018-11-20 Mayo Foundation For Medical Education And Research Bioartificial liver
CA2755708A1 (en) 2009-03-17 2010-09-23 Axcan Pharma Inc. Method of treating nonalcoholic steatohepatitis with elevated doses of ursodeoxycholic acid
WO2010127399A1 (en) 2009-05-06 2010-11-11 Walter And Eliza Hall Institute Of Medical Research Gene expression profiles and uses thereof
MX2011012183A (en) 2009-05-20 2012-03-06 Cardio3 Biosciences Sa Parmaceutical composition for the treatment of heart diseases.
JP2012527880A (en) 2009-05-29 2012-11-12 ノヴォ ノルディスク アー/エス Derivation of specific endoderm from hPS cell-derived definitive endoderm
WO2010143747A1 (en) 2009-06-10 2010-12-16 公立大学法人奈良県立医科大学 Method for production of artificial intestinal tract
CN102459574B (en) 2009-06-18 2016-06-29 塞拉提斯股份公司 Growth and the 3D culture systems of differentiation for dry (hPS) cell of people's pluripotency
JP6096509B2 (en) 2009-07-16 2017-03-15 バイオタイム インク.Biotime Inc. Methods and compositions for in vitro and in vivo cartilage formation
EP2459251B1 (en) 2009-07-30 2014-03-12 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8501476B2 (en) 2009-10-07 2013-08-06 Brown University Assays and methods for fusing cell aggregates to form proto-tissues
CN101696396A (en) 2009-10-27 2010-04-21 中国人民解放军军事医学科学院卫生学环境医学研究所 Construction method and use of model of hepatitis B virus infection in vivo
US9724410B2 (en) 2009-11-24 2017-08-08 Alderbio Holdings Llc Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity
JP2013511969A (en) 2009-11-25 2013-04-11 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Methods for hepatic differentiation of definitive endoderm cells
RU2664864C1 (en) 2009-12-23 2018-08-23 Янссен Байотек, Инк. Ways to increase expression of ngn3 and nkx6.1 in pancreatic endocrine cells
US20110231942A1 (en) * 2010-03-17 2011-09-22 Xi He Tiki1 and tiki2, wnt inhibitors
EP2550355B1 (en) 2010-03-22 2016-11-16 Takara Bio Europe AB Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of wnt-signalling pathway
EP2380920A1 (en) 2010-04-22 2011-10-26 QGel SA Hydrogel precursor formulation and production process thereof
US9234170B2 (en) 2010-04-25 2016-01-12 Mount Sinai School Of Medicine Generation of anterior foregut endoderm from pluripotent cells
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
CN103003416B (en) 2010-06-15 2016-11-16 细胞动力学国际有限公司 Inductivity pluripotent stem cell is produced from the peripheral blood of small size
SG188280A1 (en) 2010-08-24 2013-04-30 Univ Minnesota Non-static suspension culture of cell aggregates
PL2611907T3 (en) 2010-08-31 2016-11-30 Differentiation of pluripotent stem cells
WO2012068170A2 (en) 2010-11-15 2012-05-24 Jau-Nan Lee Generation of neural stem cells from human trophoblast stem cells
US9926532B2 (en) 2010-12-31 2018-03-27 Guangzhou Institute Of Biomedicine And Health Method of generating induced pluripotent stem cells and differentiated cells
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US9200258B2 (en) 2011-01-27 2015-12-01 University Of Maryland, Baltimore Multicellular organotypic model of human intestinal mucosa
EP2484750A1 (en) 2011-02-07 2012-08-08 Ecole Polytechnique Fédérale de Lausanne (EPFL) Monitoring system for cell culture
KR102117921B1 (en) 2011-02-28 2020-06-03 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Cell culture system
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
US20140158233A1 (en) 2011-05-09 2014-06-12 President And Fellows Of Harvard College Aerosol delivery to a microfluidic device
WO2012155110A1 (en) 2011-05-11 2012-11-15 Massachusetts Institute Of Technology Microgels and microtissues for use in tissue engineering
KR20190042747A (en) 2011-06-02 2019-04-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Methods and uses for ex vivo tissue culture systems
CA2840192A1 (en) 2011-06-23 2012-12-27 The Children's Hospital Of Philadelphia Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof
WO2013040087A2 (en) 2011-09-12 2013-03-21 Organovo, Inc. Platform for engineered implantable tissues and organs and methods of making the same
JP2013066414A (en) 2011-09-22 2013-04-18 National Institute Of Advanced Industrial Science & Technology Surface marker of stomach precursor cell
US20190209690A9 (en) 2011-10-12 2019-07-11 The Johns Hopkins University Bioreducible Poly (Beta-Amino Ester)s For siRNA Delivery
WO2013063588A1 (en) 2011-10-28 2013-05-02 The Board Of Trustees Of The Leland Stanford Junior University Ex vivo culture, proliferation and expansion of primary tissue organoids
WO2013067498A1 (en) 2011-11-04 2013-05-10 Tengion, Inc. Drug screening and potency assays
CA2858069C (en) 2011-12-08 2020-02-11 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
US10087422B2 (en) 2011-12-09 2018-10-02 President And Fellows Of Harvard College Organ chips and uses thereof
WO2013086486A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
AU2012356133B2 (en) 2011-12-19 2018-07-26 Koninklijke Nederlandse Akademie Van Wetenschappen A rapid quantitative assay to measure CFTR function in a primary intestinal culture model
CA2859714C (en) 2011-12-23 2023-10-17 Anthrogenesis Corporation Organoids comprising decellularized and repopulated placental vascular scaffold
EP2802647B1 (en) 2012-01-13 2020-10-28 The General Hospital Corporation Isolated human lung progenitor cells and uses thereof
CA2863310C (en) 2012-01-31 2018-11-13 Wake Forest University Health Sciences Innervation of engineered structures
US20150201588A1 (en) 2012-02-22 2015-07-23 Amgen Inc. Autologous Mammalian Models Derived from Induced Pluripotent Stem Cells and Related Methods
EP2634251A1 (en) 2012-02-29 2013-09-04 Technische Universität Berlin 3D in vitro bi-phasic cartilage-bone construct
EP2836585A4 (en) 2012-04-09 2015-12-23 Thomas J Goodwin Alternating ionic magnetic resonance (aimr) multiple-chambered culture apparatus and methods of use
WO2013174794A1 (en) 2012-05-23 2013-11-28 F. Hoffmann-La Roche Ag Compositions and methods of obtaining and using endoderm and hepatocyte cells
BR122016011808B1 (en) 2012-06-19 2021-09-21 Intercept Pharmaceuticals, Inc PROCESSES FOR PREPARING OBETICOLIC ACID FORM 1 AND CRYSTALLINE OBETICOLIC ACID
US20140099709A1 (en) 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
DE102012105540A1 (en) 2012-06-26 2014-04-24 Karlsruher Institut für Technologie Vascular model, process for its preparation and its use
EP2875360B1 (en) 2012-07-20 2018-08-08 Agency For Science, Technology And Research In vitro assay for predicting renal proximal tubular cell toxicity
US9988606B2 (en) 2012-07-24 2018-06-05 The Trustees Of Columbia University In The City Of New York Generation of airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres
GB201216796D0 (en) 2012-09-20 2012-11-07 Cambridge Entpr Ltd In vitro pancreatic differentiation
EP2712918B1 (en) 2012-09-28 2014-11-12 TissUse GmbH Multi-organ-chip with improved life time and homoeostasis
EP2716298A1 (en) 2012-10-03 2014-04-09 Institut Pasteur A nod2-dependant pathway of cytoprotection of stem cells
EP2909312A4 (en) 2012-10-19 2016-06-22 Agency Science Tech & Res Methods of differentiating stem cells into one or more cell lineages
WO2014082096A1 (en) 2012-11-26 2014-05-30 The Trustees Of Columbia University In The City Of New York Method for culture of human and mouse prostate organoids and uses thereof
EP2735326B1 (en) 2012-11-26 2017-03-08 Gambro Lundia AB Liver support system
JP2016501531A (en) 2012-12-12 2016-01-21 ザ・ブロード・インスティテュート・インコーポレイテッド Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
EP2743345A1 (en) 2012-12-13 2014-06-18 IMBA-Institut für Molekulare Biotechnologie GmbH Three dimensional heterogeneously differentiated tissue culture
US20150359849A1 (en) 2013-01-31 2015-12-17 President And Fellows Of Harvard College Methods of increasing neuronal connectivity and/or treating a neurodegenerative condition
WO2014127170A1 (en) 2013-02-13 2014-08-21 Wake Forest University Health Sciences Bioengineered liver constructs and methods relating thereto
GB201304245D0 (en) 2013-03-08 2013-04-24 Inst Quimic De Sarria Chemical compounds
WO2014165056A1 (en) 2013-03-12 2014-10-09 Board Of Regents, The University Of Texas System High throughput mechanical strain generating system for cell cultures and applications thereof
CA2905786C (en) 2013-03-13 2022-01-25 Wisconsin Alumni Research Foundation Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
EP3702443B1 (en) 2013-03-14 2022-01-19 The Brigham and Women's Hospital, Inc. Compositions and methods for epithelial stem cell expansion and culture
US20160022873A1 (en) 2013-03-14 2016-01-28 Research Institute At Nationwide Children's Hospital, Inc. Tissue engineered intestine
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
CN113564124A (en) 2013-03-14 2021-10-29 加利福尼亚大学董事会 In vitro generation of medial ganglionic eminence precursor cells
US20160237400A1 (en) 2013-03-15 2016-08-18 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
WO2014153294A1 (en) 2013-03-17 2014-09-25 The Regents Of The University Of California Method to expand and transduce cultured human small and large intestinal stem cells
US9677085B2 (en) 2013-03-18 2017-06-13 Massachusetts Institute Of Technology Engineering a heterogeneous tissue from pluripotent stem cells
EP2796873A1 (en) 2013-04-25 2014-10-29 QGel SA Method for a cell-based drug screening assay and the use thereof
US20160245653A1 (en) 2013-04-30 2016-08-25 Sangtae Park Cylindrical resonator gyroscope
KR102710014B1 (en) 2013-05-08 2024-09-26 인리젠 Organoids comprising isolated renal cells and uses thereof
US10545133B2 (en) 2013-05-13 2020-01-28 The Johns Hopkins University Molecular signatures of invasive cancer subpopulations
WO2014197622A2 (en) 2013-06-04 2014-12-11 The Regents Of The University Of California Liver-mimetic device and method for simulation of hepatic function using such device
JP6253265B2 (en) 2013-06-05 2017-12-27 学校法人関西医科大学 Method for isolating esophageal epithelial stem cells
CA2913559C (en) 2013-06-10 2024-05-28 Kuraray Co., Ltd. Tissue structure and preparation method thereof
US10900022B2 (en) 2013-06-14 2021-01-26 The University Of Queensland Renal progenitor cells
KR102184473B1 (en) 2013-07-23 2020-11-30 고리츠다이가쿠호진 요코하마시리츠다이가쿠 Method for providing vascular system in biological tissue
KR102456567B1 (en) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 Compounds and methods for inhibiting phosphate transport
KR20190022939A (en) 2013-08-28 2019-03-06 프로메테라 바이오사이언시즈 에스.에이./엔.브이. Method for producing adult liver progenitor cells
GB201317869D0 (en) 2013-10-09 2013-11-20 Cambridge Entpr Ltd In vitro production of foregut stem cells
US10087416B2 (en) 2013-10-25 2018-10-02 Agency For Science, Technology And Research Culturing pluripotent stem cells
US10357515B2 (en) 2013-11-22 2019-07-23 Cellectis Method for generating batches of allogeneic T-cells with averaged potency
MY188836A (en) 2013-11-22 2022-01-07 Sumitomo Chemical Co Method for manufacturing telencephalon or progenitor tissue thereof
EP2876441B1 (en) 2013-11-26 2017-10-25 Bergen Teknologioverforing AS Quantitative analysis of contact-depending cell-to-cell transfer and disease transmission
GB2584034B (en) 2013-12-20 2021-03-24 Harvard College Organomimetic devices and methods of use and manufacturing thereof
KR102443162B1 (en) 2014-01-14 2022-09-14 예일 유니버시티 Compositions and methods of preparing airway cells
US11648335B2 (en) 2014-01-31 2023-05-16 Wake Forest University Health Sciences Organ/tissue decellularization, framework maintenance and recellularization
CN106456669A (en) 2014-02-11 2017-02-22 人类起源公司 Micro-organoids, and methods of making and using the same
US10369254B2 (en) 2014-02-26 2019-08-06 The Regents Of The University Of California Method and apparatus for in vitro kidney organogenesis
US20170067014A1 (en) 2014-02-27 2017-03-09 Public University Corporation Yokohama City Univer sity Method for generating cell condensate for self-organization
DE102014003465A1 (en) 2014-03-11 2015-09-17 NeuroProof GmbH Obtaining brain region-specific neuronal cultures from three-dimensional tissue cultures of stem cells
WO2015140257A1 (en) 2014-03-19 2015-09-24 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for inducing human cholangiocyte differentiation
JP6556825B2 (en) 2014-03-21 2019-08-07 トビラ セラピューティクス, インコーポレイテッド Senicrivirok for treating fibrosis
US20170023550A1 (en) 2014-04-04 2017-01-26 Organovo, Inc. Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
WO2015156929A1 (en) 2014-04-07 2015-10-15 The Trustees Of Columbia University In The City Of New York Method for culture of human bladder cell lines and organoids and uses thereof
US10222370B2 (en) 2014-04-07 2019-03-05 Rush University Medical Center Screening assay for choice of prebiotic to prevent/treat gastrointestinal and systemic diseases
PT3129018T (en) 2014-04-11 2020-01-15 Cymabay Therapeutics Inc Treatment of nafld and nash
MX2016014099A (en) 2014-04-27 2017-07-28 Univ New York State Res Found Enamel products and methods of use.
WO2015173425A1 (en) * 2014-05-16 2015-11-19 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method for organoids
EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
CN106536707B (en) 2014-05-29 2018-12-25 西奈山伊坎医学院 The method and apparatus of heart organoid are manufactured in bioreactor system
US10426757B2 (en) 2014-05-29 2019-10-01 Whitehead Institute For Biomedical Research Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function
EP3152295B1 (en) 2014-06-05 2020-07-29 Cedars-Sinai Medical Center A novel and efficient method for reprogramming immortalized lymphoblastoid cell lines to induced pluripotent stem cells
WO2015185714A1 (en) 2014-06-06 2015-12-10 Vrije Universiteit Brussel Human hepatic 3d co-culture model and uses thereof
CA2953122A1 (en) 2014-06-20 2015-12-23 Rutgers, The State University Of New Jersey Single cell-derived organoids
WO2015200901A1 (en) 2014-06-26 2015-12-30 The Trustees Of Columbia University In The City Of New York Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
EP3169811A4 (en) 2014-07-17 2017-12-27 Celmatix Inc. Methods and systems for assessing infertility and related pathologies
BR112017001623B1 (en) 2014-07-29 2022-11-29 Shenzhen Hightide Biopharmaceutical, Ltd ACID-BASE ADDITION SALT IN SUBSTANTIALLY PURE FORM, PHARMACEUTICAL COMPOSITION COMPRISING AN AMOUNT OF SAID SALT AND ITS USES
WO2016015158A1 (en) 2014-07-30 2016-02-04 University Health Network Organoids for drug screening and personalized medicine
EP3183336B1 (en) 2014-08-22 2020-11-25 Cambridge Enterprise Limited Resetting pluripotent stem cells
CA2958851C (en) 2014-08-28 2023-05-09 Promethera Biosciences S.A./N.V. Method for producing adult liver progenitor cells
EP3186365A4 (en) 2014-08-29 2018-04-25 Immunomedics, Inc. Identification of cancer genes by in-vivo fusion of human cancer cells and animal cells
WO2016040860A1 (en) 2014-09-12 2016-03-17 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
MA40495A (en) 2014-10-06 2016-04-14 Organovo Inc Engineered renal tissues, arrays thereof, and methods of making the same
US20170304369A1 (en) 2014-10-08 2017-10-26 Agency For Science, Technology And Research Methods of differentiating stem cells into liver cell lineages
EP3207122B1 (en) 2014-10-14 2019-05-08 FUJIFILM Cellular Dynamics, Inc. Generation of keratinocytes from pluripotent stem cells and maintenance of keratinocyte cultures
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
WO2016069897A1 (en) 2014-10-30 2016-05-06 Massachusetts Institute Of Technology Materials and methods for rescue of ischemic tissue and regeneration of tissue integrity during restriction, engraftment and transplantation
WO2016073989A2 (en) 2014-11-07 2016-05-12 The Trustees Of Columbia University In The City Of New York Osteochondroreticular stem cells for bone and cartilage regeneration
AU2015353853B2 (en) 2014-11-25 2020-10-15 President And Fellows Of Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
US20170260501A1 (en) 2014-11-25 2017-09-14 International Stem Cell Corporation Derivation of neural crest stem cells and uses thereof
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
AU2014277667B2 (en) 2014-12-15 2022-07-14 The University Of Queensland Differentiation of pluripotent stem cells to form renal organoids
CA2972057C (en) 2014-12-22 2023-06-13 Ecole Polytechnique Federale De Lausanne (Epfl) Microstructured thin hydrogel films
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
US20180021341A1 (en) 2015-01-09 2018-01-25 Gilead Apollo, Llc Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease
EP3252144A4 (en) 2015-01-28 2018-08-08 Public University Corporation Yokohama City University Method for preparing bone marrow cell aggregate
US20160256672A1 (en) 2015-02-10 2016-09-08 Cedars-Sinai Medical Center Induced pluripotent stem cell-derived hepatocyte based bioartificial liver device
CN105985395A (en) 2015-02-13 2016-10-05 江苏奥赛康药业股份有限公司 Obeticholic acid compound, and medicinal composition containing compound
WO2016140716A1 (en) 2015-03-02 2016-09-09 The Trustees Of Columbia University In The City Of New York Injectable microtissue systems, devices, and methods
US11214768B2 (en) 2015-03-03 2022-01-04 President And Fellows Of Harvard College Methods of generating functional human tissue
EP3265797B1 (en) 2015-03-06 2022-10-05 Micromass UK Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device
WO2016144769A1 (en) 2015-03-06 2016-09-15 University Of North Carolina At Chapel Hill HUMAN FIBROLAMELLAR HEPATOCELLULAR CARCINOMAS (hFL-HCCS)
MX2017011586A (en) 2015-03-09 2017-10-26 Intekrin Therapeutics Inc Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy.
WO2016154330A1 (en) 2015-03-23 2016-09-29 Whitehead Institute For Biomedical Research Reporter of genomic methylation and uses thereof
TN2017000426A1 (en) 2015-04-07 2019-04-12 Intercept Pharmaceuticals Inc Pharmaceutical compositions for combination therapy
US10557124B2 (en) 2015-04-22 2020-02-11 The Regents Of The University Of Michigan Compositions and methods for obtaining stem cell derived lung tissue, and related uses thereof
US10087417B2 (en) 2015-04-22 2018-10-02 William J. Freed Three-dimensional model of human cortex
CN104877964A (en) 2015-04-24 2015-09-02 赵振民 In vitro construction method for salivary glands organs and acinus
PE20180690A1 (en) 2015-04-27 2018-04-23 Intercept Pharmaceuticals Inc OBETICOLIC ACID COMPOSITIONS AND METHODS OF USE
EP3289072B1 (en) 2015-04-30 2023-08-16 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Means and methods for generation of breast stem cells
WO2016183143A1 (en) 2015-05-11 2016-11-17 The Trustees Of Columbia University Inthe City Of New York Engineered adult-like human heart tissue
US10913932B2 (en) 2015-06-03 2021-02-09 Takara Bio Europe Ab Maturation of mammalian hepatocytes
GB201510950D0 (en) 2015-06-22 2015-08-05 Cambridge Entpr Ltd In vitro Production of Cholangiocytes
WO2016210313A1 (en) 2015-06-24 2016-12-29 Whitehead Institute For Biomedical Research Culture medium for generating microglia from pluripotent stem cells and related methods
EP3313416A4 (en) 2015-06-26 2019-02-20 The Trustees of Columbia University in the City of New York Genetically modified ips cells that carry a marker to report expression of neurogenin3, tph2, foxo1 and/or insulin genes
WO2017009263A1 (en) 2015-07-10 2017-01-19 Etablissement Francais Du Sang Method for obtaining human brown/beige adipocytes
US10449221B2 (en) 2015-07-29 2019-10-22 Trustees Of Boston University Differentiation of stem cells into thyroid tissue
WO2017036533A1 (en) 2015-09-03 2017-03-09 Ecole Polytechnique Federale De Lausanne (Epfl) Three-dimensional hydrogels for culturing adult epithelial stem cells and organoids
WO2017041041A1 (en) 2015-09-03 2017-03-09 The Brigham And Women's Hospital, Inc. Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease
EP3350313A4 (en) 2015-09-15 2019-06-12 Agency For Science, Technology And Research (A*star) Derivation of liver organoids from human pluripotent stem cells
EP3349751A4 (en) 2015-09-16 2019-05-22 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
WO2017049243A1 (en) 2015-09-17 2017-03-23 Bonventre Joseph V Methods of generating nephrons from human pluripotent stem cells
WO2017059171A1 (en) 2015-10-02 2017-04-06 Wake Forest University Health Sciences Spontaneously beating cardiac organoid constructs and integrated body-on-chip apparatus containing the same
LU92845B1 (en) 2015-10-08 2017-05-02 Univ Du Luxembourg Campus Belval Means and methods for generating midbrain organoids
KR20180068997A (en) 2015-10-15 2018-06-22 웨이크 포리스트 유니버시티 헬스 사이언시즈 METHOD AND APPARATUS FOR THE PRODUCTION OF INTERBITROS STRUCTURE
US10993433B2 (en) 2015-10-15 2021-05-04 Wake Forest University Health Sciences Method of producing in vitro testicular constructs and uses thereof
US10801068B2 (en) 2015-10-16 2020-10-13 The Trustees Of Columbia University In The City Of New York JAG1 expression predicts therapeutic response in NASH
US11001811B2 (en) 2015-10-16 2021-05-11 Wake Forest University Health Sciences Multi-layer airway organoids and methods of making and using the same
GB2561312B (en) 2015-10-19 2021-03-24 Emulate Inc Microfluidic model of the blood brain barrier
US20180057788A1 (en) 2016-08-29 2018-03-01 EMULATE, Inc. Development of spinal cord on a microfluidic chip
US10865381B2 (en) 2015-10-20 2020-12-15 FUJIFILM Cellular Dynamics, Inc. Multi-lineage hematopoietic precursor cell production by genetic programming
WO2017070471A1 (en) 2015-10-21 2017-04-27 Indiana University Research And Technology Corporation Methods of generating human inner ear sensory epithelia and sensory neurons
JP7018875B2 (en) 2015-10-21 2022-02-14 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション Induction of human skin organoids from pluripotent stem cells
WO2017075389A1 (en) 2015-10-30 2017-05-04 The Regents Of The Universtiy Of California Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells
WO2017077535A1 (en) 2015-11-02 2017-05-11 Carmel-Haifa University Economic Corporation Ltd. Apoptosis related protein in the tgf-beta signaling pathway (arts) mimetic compounds, compositions, methods and uses thereof in induction of differentiation and/or apoptosis of premalignant and malignant cells, thereby restoring their normal-like phenotype
WO2017079632A1 (en) 2015-11-04 2017-05-11 Cedars-Sinai Medical Center Patient-derived ctc-xenograft models
MX2018005096A (en) 2015-11-06 2018-08-15 Gemphire Therapeutics Inc Gemcabene combinations for the treatment of cardiovascular disease.
CN114099058A (en) 2015-11-12 2022-03-01 博奥司时代有限责任公司 Systems and methods for producing gastrointestinal tract tissue
WO2017083705A1 (en) 2015-11-13 2017-05-18 The Johns Hopkins University Cell culture system and method of use thereof
CA3013309A1 (en) 2015-12-04 2017-06-08 President And Fellows Of Harvard College Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof
CN108699528A (en) 2015-12-23 2018-10-23 纪念斯隆-凯特琳癌症中心 Pass through people's enteric nervous ridge pedigree feasible treatment and drug development based on cell derived from multipotential stem cell in congenital megacolon
KR101733137B1 (en) 2015-12-30 2017-05-08 (주)엑셀세라퓨틱스 Method of production for 3D cartilage organoid block
JP6694512B2 (en) 2015-12-30 2020-05-13 フジフィルム セルラー ダイナミクス,インコーポレイテッド Microtissue formation using stem cell-derived human hepatocytes
US20190367868A1 (en) 2015-12-31 2019-12-05 President And Fellows Of Harvard College Neurons and compositions and methods for producing the same
US20190002835A1 (en) 2015-12-31 2019-01-03 President And Fellows Of Harvard College Methods for generating neural tissue and uses thereof
JP2019506153A (en) 2016-01-08 2019-03-07 マサチューセッツ インスティテュート オブ テクノロジー Production of differentiated enteroendocrine cells and insulin-producing cells
EP3190176A1 (en) 2016-01-11 2017-07-12 IMBA-Institut für Molekulare Biotechnologie GmbH Method for tissue culture development on scaffold and differentiated tissue culture
EP3402493A4 (en) 2016-01-14 2019-08-21 Ohio State Innovation Foundation A neural organoid composition and methods of use
US20170205396A1 (en) 2016-01-15 2017-07-20 Salk Institute For Biological Studies Systems and methods for culturing nephron progenitor cells
JP2019506861A (en) 2016-02-01 2019-03-14 シーダーズ−サイナイ メディカル センター System and method for enterocyte growth in a microfluidic device
CA3013630A1 (en) 2016-02-10 2017-08-17 Wake Forest University Health Sciences Model system of liver fibrosis and method of making and using the same
WO2017139638A1 (en) 2016-02-11 2017-08-17 The Johns Hopkins University Compositions and methods for neuralgenesis
WO2017143100A1 (en) 2016-02-16 2017-08-24 The Board Of Trustees Of The Leland Stanford Junior University Novel recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
US20190100724A1 (en) 2016-02-18 2019-04-04 Keio University Cell culture medium, culture method, and organoid
JP7097814B2 (en) 2016-02-19 2022-07-08 プロセラ セラピューティクス アーベー Genetic markers for engraftment of human ventricular progenitor cells
US20170267970A1 (en) 2016-02-29 2017-09-21 Whitehead Institute For Biomedical Research Three-Dimensional Hydrogels that Support Growth of Physiologically Relevant Tissue and Methods of Use Thereof
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
CN109153962A (en) 2016-03-08 2019-01-04 耶路撒冷希伯来大学的益生研究开发有限公司 The method and system of continuous biological sensing
EP3430132A4 (en) 2016-03-14 2019-12-25 Agency for Science, Technology and Research Generation of midbrain-specific organoids from human pluripotent stem cells
US10772863B2 (en) 2016-03-15 2020-09-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Methods of inducing metabolic maturation of human pluripotent stem cells— derived hepatocytes
US20190076482A1 (en) 2016-03-15 2019-03-14 The Johns Hopkins University Enhanced organoid formation and intestinal stem cell renewal
JP6960140B2 (en) 2016-03-16 2021-11-05 公立大学法人横浜市立大学 Tumor tissue reproduction method
JP7002530B2 (en) 2016-03-29 2022-02-04 エスエムエスバイオテック インコーポレイテッド Compositions and Methods Using Small Motility Stem Cells
US20210155895A1 (en) 2016-04-04 2021-05-27 Lineage Cell Therapeutics, Inc. Pluripotent Stem Cell-Derived 3D Retinal Tissue and Uses Thereof
EP3228306A1 (en) 2016-04-04 2017-10-11 ratiopharm GmbH Complex compound comprising obeticholic acid and cyclodextrin and pharmaceutical formulation comprising the complex compound
JP2019513418A (en) 2016-04-04 2019-05-30 フメルティス Diagnostic methods for patient-specific treatment decisions in cancer treatment
WO2017175876A1 (en) 2016-04-05 2017-10-12 学校法人自治医科大学 Method for reestablishing stem cells
WO2017184586A1 (en) 2016-04-18 2017-10-26 The Trustees Of Columbia University In The City Of New York Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (nash)
RU2717677C1 (en) 2016-04-22 2020-03-25 Тайваньж Фармасьютикалс Со., Лтд. Nalmefen, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease
US20170321188A1 (en) 2016-05-04 2017-11-09 The Research Foundation For The State University Of New York Methods of generating retinal progenitor cell preparations and uses thereof
JP6963882B2 (en) 2016-05-05 2021-11-10 チルドレンズ ホスピタル メディカル センター Methods for the in vitro production of fundic tissue and compositions associated with such methods.
CA3025344A1 (en) 2016-05-25 2017-11-30 Salk Institute For Biological Studies Compositions and methods for organoid generation and disease modeling
US20170349659A1 (en) 2016-06-03 2017-12-07 The Board Of Trustees Of The Leland Stanford Junior University Wnt signaling agonist molecules
BR112018076095A2 (en) 2016-06-14 2019-03-26 Cellply S.R.L. screening kit and method
US12129491B2 (en) 2016-06-15 2024-10-29 Children's Medical Center Corporation Methods and compositions relating to lung cell differentiation
US10221395B2 (en) 2016-06-16 2019-03-05 Cedars-Sinai Medical Center Efficient method for reprogramming blood to induced pluripotent stem cells
GB201610748D0 (en) 2016-06-20 2016-08-03 Koninklijke Nederlandse Akademie Van Wetenschappen Improved diffrentation method
GB201611982D0 (en) 2016-07-11 2016-08-24 Cellesce Ltd Cell culture
EP3275997A1 (en) 2016-07-28 2018-01-31 QGel SA Hydrogel precursor formulation and the use thereof
WO2018026947A1 (en) 2016-08-02 2018-02-08 Memorial Sloan-Kettering Cancer Center Treating metastatic cancer and model systems for metastatic disease
KR20230084308A (en) 2016-08-03 2023-06-12 웨이크 포리스트 유니버시티 헬스 사이언시즈 Cancer modeling platforms and methods of using the same
AU2017306698B2 (en) 2016-08-04 2023-03-30 Wake Forest University Health Sciences Blood brain barrier model and methods of making and using the same
KR102417262B1 (en) 2016-08-24 2022-07-07 각고호우징 게이오기주크 2D organoid for infection/proliferation culture of human diarrhea virus and its use
KR102634265B1 (en) 2016-08-26 2024-02-08 더 유니버서티 어브 퀸슬랜드 Cardiomyocyte maturation
EP3503902A4 (en) 2016-08-28 2020-04-22 Baylor College of Medicine A novel chicken egg-based metastasis model for cancer
US20210301349A1 (en) 2016-08-30 2021-09-30 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating a tumor suppressor deficient cancer
US20210277102A1 (en) 2016-08-30 2021-09-09 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating a tumor suppressor deficient cancer
EP3534907A4 (en) 2016-11-04 2020-06-24 Children's Hospital Medical Center Compositions and methods of treating liver disease
US11492595B2 (en) 2016-11-23 2022-11-08 Morphocell Technologies Inc. Encapsulated liver tissue
NZ753873A (en) * 2016-12-05 2023-01-27 Children’S Hospital Medical Center Colonic organoids and methods of making and using same
GB201622222D0 (en) 2016-12-23 2017-02-08 Cs Genetics Ltd Reagents and methods for molecular barcoding of nucleic acids of single cells
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
US20210115366A1 (en) 2017-04-24 2021-04-22 Children's Hospital Medical Center Methods of making improved human intestinal organoid compositions via application of strain and human intestinal organoid compositions thereof
EP3395942A1 (en) 2017-04-25 2018-10-31 IMBA-Institut für Molekulare Biotechnologie GmbH Bi- or multi-differentiated organoid
NZ759164A (en) 2017-06-09 2023-02-24 Children’S Hospital Medical Center Liver organoid compositions and methods of making and using same
US20210189349A1 (en) 2017-10-10 2021-06-24 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
WO2019126626A1 (en) 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
CA3106634A1 (en) 2018-07-26 2020-01-30 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CN112823012A (en) 2018-09-12 2021-05-18 儿童医院医学中心 Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
SG11202102999QA (en) 2018-09-27 2021-04-29 Childrens Hospital Med Ct Liver support system comprising liver organoids and methods of making and using same
US20220090011A1 (en) 2019-02-01 2022-03-24 The University Of Hong Kong Innervated organoid compositions and methods of making same

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