SG10201901578UA - Processes for the preparation of pyrimidinylcyclopentane compounds - Google Patents

Processes for the preparation of pyrimidinylcyclopentane compounds

Info

Publication number
SG10201901578UA
SG10201901578UA SG10201901578UA SG10201901578UA SG10201901578UA SG 10201901578U A SG10201901578U A SG 10201901578UA SG 10201901578U A SG10201901578U A SG 10201901578UA SG 10201901578U A SG10201901578U A SG 10201901578UA SG 10201901578U A SG10201901578U A SG 10201901578UA
Authority
SG
Singapore
Prior art keywords
preparation
processes
pyrimidinylcyclopentane
compounds
pyrimidinylcyclopentane compounds
Prior art date
Application number
SG10201901578UA
Other languages
English (en)
Inventor
Hans Iding
Reinhard Reents
Michelangelo Scalone
Francis Gosselin
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Publication of SG10201901578UA publication Critical patent/SG10201901578UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/02Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165Heterorings having nitrogen atoms as the only ring heteroatoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
SG10201901578UA 2013-11-15 2014-11-13 Processes for the preparation of pyrimidinylcyclopentane compounds SG10201901578UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13193030 2013-11-15

Publications (1)

Publication Number Publication Date
SG10201901578UA true SG10201901578UA (en) 2019-03-28

Family

ID=49582648

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201901578UA SG10201901578UA (en) 2013-11-15 2014-11-13 Processes for the preparation of pyrimidinylcyclopentane compounds

Country Status (22)

Country Link
US (3) US9862689B2 (ko)
EP (3) EP4282973A3 (ko)
JP (4) JP6374503B2 (ko)
KR (2) KR102493603B1 (ko)
CN (3) CN105899492B (ko)
AR (1) AR098427A1 (ko)
AU (5) AU2014348570B2 (ko)
CA (2) CA3207199A1 (ko)
ES (2) ES2957314T3 (ko)
HK (1) HK1223102A1 (ko)
HR (2) HRP20231100T1 (ko)
HU (1) HUE063095T2 (ko)
IL (3) IL245636B (ko)
MX (3) MX367620B (ko)
MY (2) MY191759A (ko)
NZ (1) NZ720805A (ko)
PL (2) PL3656764T3 (ko)
RU (1) RU2702355C1 (ko)
SG (1) SG10201901578UA (ko)
SI (1) SI3068770T1 (ko)
WO (1) WO2015073739A1 (ko)
ZA (2) ZA201603434B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2957314T3 (es) * 2013-11-15 2024-01-17 Hoffmann La Roche Procesos para la preparación de compuestos de pirimidinilciclopentano
US10457648B2 (en) 2014-09-26 2019-10-29 Genentech Inc. Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds
TWI736660B (zh) 2016-08-10 2021-08-21 瑞士商赫孚孟拉羅股份公司 包含Akt蛋白質激酶抑制劑之醫藥組合物
GB201802383D0 (en) * 2018-02-14 2018-03-28 Givaudan Sa Process

Family Cites Families (22)

* Cited by examiner, † Cited by third party
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US6545165B1 (en) 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
KR100927910B1 (ko) * 2005-05-24 2009-11-19 에프. 호프만-라 로슈 아게 (s)-4-플루오로메틸-다이하이드로-퓨란-2-온의 제조
CN101198594A (zh) * 2005-06-22 2008-06-11 尼科梅德有限责任公司 用于制备生产三环苯并咪唑类的中间体的方法
UA95641C2 (en) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2049500B1 (en) * 2006-07-06 2011-09-07 Array Biopharma, Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
CN101784669B (zh) 2007-08-24 2015-02-18 科德克希思公司 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽
RU2504542C2 (ru) 2008-01-09 2014-01-20 Эррэй Биофарма Инк. Гидроксилированные пиримидилциклопентаны в качестве ингибиторов протеинкиназы (акт)
BRPI0907372A2 (pt) 2008-01-09 2015-07-14 Array Biopharma Inc Pirimidil ciclopentano hidroxilado como inibidor de proteína quinase akt
AR070176A1 (es) * 2008-01-17 2010-03-17 Novartis Ag Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis
SI2329013T1 (sl) 2008-08-27 2016-03-31 Codexis, Inc. Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina
WO2010025085A2 (en) 2008-08-29 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
US20110054174A1 (en) * 2009-08-28 2011-03-03 Stephan Bachmann Process for the preparation of a glucokinase activator compound
RU2012148699A (ru) * 2010-04-16 2014-05-27 Дженентек, Инк. Foxo3a как прогностический биомаркер для эффективности ингибитора пути киназы pi3k/акт
HUE036513T2 (hu) * 2011-04-01 2018-07-30 Genentech Inc AKT inhibitor vegyület és abirateron kombinációja terápiás kezelésekben való alkalmazásra
AU2013262548B2 (en) * 2012-05-17 2017-09-21 Genentech, Inc. Amorphous form of an AKT inhibiting pyrimidinyl - cyclopentane compound, compositions and methods thereof
SI2861582T1 (sl) 2012-05-17 2016-09-30 Array Biopharma, Inc. Postopek za izdelavo hidroksiliranih ciklopentilpirimidinskih spojin
MA37751B1 (fr) * 2012-05-17 2018-08-31 Genentech Inc Procédé de préparation de composés d'acides aminés
AU2013262521B2 (en) * 2012-05-17 2017-03-02 Genentech, Inc. Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
DK2861583T3 (en) 2012-05-17 2016-10-03 Array Biopharma Inc METHOD OF PRODUCING hydroxylated CYCLOPENTYLPYRIMIDINFORBINDELSER
ES2957314T3 (es) * 2013-11-15 2024-01-17 Hoffmann La Roche Procesos para la preparación de compuestos de pirimidinilciclopentano
US10457648B2 (en) 2014-09-26 2019-10-29 Genentech Inc. Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds

Also Published As

Publication number Publication date
CN105899492B (zh) 2021-08-24
IL281072A (en) 2021-04-29
ZA202002611B (en) 2023-10-25
HRP20192340T1 (hr) 2020-04-03
SI3068770T1 (sl) 2020-02-28
EP4282973A3 (en) 2024-03-27
AU2024205845A1 (en) 2024-09-05
KR20220139440A (ko) 2022-10-14
KR102493603B1 (ko) 2023-01-31
IL281072B (en) 2022-05-01
PL3656764T3 (pl) 2024-01-22
EP3656764A1 (en) 2020-05-27
IL245636B (en) 2019-12-31
CA2930870C (en) 2023-09-19
HUE063095T2 (hu) 2023-12-28
HK1223102A1 (zh) 2017-07-21
CN112898210A (zh) 2021-06-04
WO2015073739A1 (en) 2015-05-21
KR20160075816A (ko) 2016-06-29
MY191759A (en) 2022-07-14
KR102698200B1 (ko) 2024-08-26
IL271331A (en) 2020-01-30
RU2019130505A (ru) 2020-02-18
US10858324B2 (en) 2020-12-08
RU2702355C1 (ru) 2019-10-08
JP2021100953A (ja) 2021-07-08
CA2930870A1 (en) 2015-05-21
ZA201603434B (en) 2020-08-26
ES2957314T3 (es) 2024-01-17
ES2765511T3 (es) 2020-06-09
BR112016011048A8 (pt) 2020-04-22
EP3656764B1 (en) 2023-07-05
AU2014348570B2 (en) 2019-02-28
EP3656764C0 (en) 2023-07-05
EP3068770B1 (en) 2019-10-23
JP2019218384A (ja) 2019-12-26
MX2016006299A (es) 2017-02-22
IL271331B (en) 2021-03-25
MX2020009462A (es) 2021-08-31
US10435378B2 (en) 2019-10-08
US20180086722A1 (en) 2018-03-29
JP2018052966A (ja) 2018-04-05
AU2021202196A1 (en) 2021-05-06
PL3068770T3 (pl) 2020-04-30
AU2014348570A1 (en) 2016-06-09
JP6374503B2 (ja) 2018-08-15
CA3207199A1 (en) 2015-05-21
CN110590606A (zh) 2019-12-20
MX367620B (es) 2019-08-28
MX2019006959A (es) 2019-08-01
AU2019202461A1 (en) 2019-05-02
JP6634428B2 (ja) 2020-01-22
BR112016011048A2 (pt) 2017-08-08
CN110590606B (zh) 2023-02-17
MY174153A (en) 2020-03-11
RU2016123365A (ru) 2017-12-18
AR098427A1 (es) 2016-05-26
AU2022275477A1 (en) 2023-01-05
HRP20231100T1 (hr) 2023-12-22
IL245636A0 (en) 2016-06-30
JP6857219B2 (ja) 2021-04-14
AU2019202461B2 (en) 2021-01-14
EP4282973A2 (en) 2023-11-29
EP3068770A4 (en) 2017-04-19
CN105899492A (zh) 2016-08-24
US20200062717A1 (en) 2020-02-27
US20160297773A1 (en) 2016-10-13
NZ720805A (en) 2022-01-28
US9862689B2 (en) 2018-01-09
JP2016539939A (ja) 2016-12-22
JP7377828B2 (ja) 2023-11-10
EP3068770A1 (en) 2016-09-21

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