SG10201901578UA - Processes for the preparation of pyrimidinylcyclopentane compounds - Google Patents
Processes for the preparation of pyrimidinylcyclopentane compoundsInfo
- Publication number
- SG10201901578UA SG10201901578UA SG10201901578UA SG10201901578UA SG10201901578UA SG 10201901578U A SG10201901578U A SG 10201901578UA SG 10201901578U A SG10201901578U A SG 10201901578UA SG 10201901578U A SG10201901578U A SG 10201901578UA SG 10201901578U A SG10201901578U A SG 10201901578UA
- Authority
- SG
- Singapore
- Prior art keywords
- preparation
- processes
- pyrimidinylcyclopentane
- compounds
- pyrimidinylcyclopentane compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13193030 | 2013-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201901578UA true SG10201901578UA (en) | 2019-03-28 |
Family
ID=49582648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201901578UA SG10201901578UA (en) | 2013-11-15 | 2014-11-13 | Processes for the preparation of pyrimidinylcyclopentane compounds |
Country Status (22)
Country | Link |
---|---|
US (3) | US9862689B2 (ko) |
EP (3) | EP4282973A3 (ko) |
JP (4) | JP6374503B2 (ko) |
KR (2) | KR102493603B1 (ko) |
CN (3) | CN105899492B (ko) |
AR (1) | AR098427A1 (ko) |
AU (5) | AU2014348570B2 (ko) |
CA (2) | CA3207199A1 (ko) |
ES (2) | ES2957314T3 (ko) |
HK (1) | HK1223102A1 (ko) |
HR (2) | HRP20231100T1 (ko) |
HU (1) | HUE063095T2 (ko) |
IL (3) | IL245636B (ko) |
MX (3) | MX367620B (ko) |
MY (2) | MY191759A (ko) |
NZ (1) | NZ720805A (ko) |
PL (2) | PL3656764T3 (ko) |
RU (1) | RU2702355C1 (ko) |
SG (1) | SG10201901578UA (ko) |
SI (1) | SI3068770T1 (ko) |
WO (1) | WO2015073739A1 (ko) |
ZA (2) | ZA201603434B (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2957314T3 (es) * | 2013-11-15 | 2024-01-17 | Hoffmann La Roche | Procesos para la preparación de compuestos de pirimidinilciclopentano |
US10457648B2 (en) | 2014-09-26 | 2019-10-29 | Genentech Inc. | Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds |
TWI736660B (zh) | 2016-08-10 | 2021-08-21 | 瑞士商赫孚孟拉羅股份公司 | 包含Akt蛋白質激酶抑制劑之醫藥組合物 |
GB201802383D0 (en) * | 2018-02-14 | 2018-03-28 | Givaudan Sa | Process |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6545165B1 (en) | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
KR100927910B1 (ko) * | 2005-05-24 | 2009-11-19 | 에프. 호프만-라 로슈 아게 | (s)-4-플루오로메틸-다이하이드로-퓨란-2-온의 제조 |
CN101198594A (zh) * | 2005-06-22 | 2008-06-11 | 尼科梅德有限责任公司 | 用于制备生产三环苯并咪唑类的中间体的方法 |
UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
EP2049500B1 (en) * | 2006-07-06 | 2011-09-07 | Array Biopharma, Inc. | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
CN101784669B (zh) | 2007-08-24 | 2015-02-18 | 科德克希思公司 | 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽 |
RU2504542C2 (ru) | 2008-01-09 | 2014-01-20 | Эррэй Биофарма Инк. | Гидроксилированные пиримидилциклопентаны в качестве ингибиторов протеинкиназы (акт) |
BRPI0907372A2 (pt) | 2008-01-09 | 2015-07-14 | Array Biopharma Inc | Pirimidil ciclopentano hidroxilado como inibidor de proteína quinase akt |
AR070176A1 (es) * | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
SI2329013T1 (sl) | 2008-08-27 | 2016-03-31 | Codexis, Inc. | Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina |
WO2010025085A2 (en) | 2008-08-29 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
US20110054174A1 (en) * | 2009-08-28 | 2011-03-03 | Stephan Bachmann | Process for the preparation of a glucokinase activator compound |
RU2012148699A (ru) * | 2010-04-16 | 2014-05-27 | Дженентек, Инк. | Foxo3a как прогностический биомаркер для эффективности ингибитора пути киназы pi3k/акт |
HUE036513T2 (hu) * | 2011-04-01 | 2018-07-30 | Genentech Inc | AKT inhibitor vegyület és abirateron kombinációja terápiás kezelésekben való alkalmazásra |
AU2013262548B2 (en) * | 2012-05-17 | 2017-09-21 | Genentech, Inc. | Amorphous form of an AKT inhibiting pyrimidinyl - cyclopentane compound, compositions and methods thereof |
SI2861582T1 (sl) | 2012-05-17 | 2016-09-30 | Array Biopharma, Inc. | Postopek za izdelavo hidroksiliranih ciklopentilpirimidinskih spojin |
MA37751B1 (fr) * | 2012-05-17 | 2018-08-31 | Genentech Inc | Procédé de préparation de composés d'acides aminés |
AU2013262521B2 (en) * | 2012-05-17 | 2017-03-02 | Genentech, Inc. | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
DK2861583T3 (en) | 2012-05-17 | 2016-10-03 | Array Biopharma Inc | METHOD OF PRODUCING hydroxylated CYCLOPENTYLPYRIMIDINFORBINDELSER |
ES2957314T3 (es) * | 2013-11-15 | 2024-01-17 | Hoffmann La Roche | Procesos para la preparación de compuestos de pirimidinilciclopentano |
US10457648B2 (en) | 2014-09-26 | 2019-10-29 | Genentech Inc. | Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds |
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2014
- 2014-11-13 ES ES19204562T patent/ES2957314T3/es active Active
- 2014-11-13 MY MYPI2019002660A patent/MY191759A/en unknown
- 2014-11-13 CN CN201480072954.1A patent/CN105899492B/zh active Active
- 2014-11-13 US US15/036,741 patent/US9862689B2/en active Active
- 2014-11-13 AU AU2014348570A patent/AU2014348570B2/en active Active
- 2014-11-13 SI SI201431455T patent/SI3068770T1/sl unknown
- 2014-11-13 KR KR1020167015742A patent/KR102493603B1/ko active IP Right Grant
- 2014-11-13 EP EP23182382.4A patent/EP4282973A3/en active Pending
- 2014-11-13 EP EP14863015.5A patent/EP3068770B1/en active Active
- 2014-11-13 NZ NZ720805A patent/NZ720805A/en unknown
- 2014-11-13 WO PCT/US2014/065567 patent/WO2015073739A1/en active Application Filing
- 2014-11-13 CN CN201910735465.4A patent/CN110590606B/zh active Active
- 2014-11-13 HR HRP20231100TT patent/HRP20231100T1/hr unknown
- 2014-11-13 PL PL19204562.3T patent/PL3656764T3/pl unknown
- 2014-11-13 MX MX2016006299A patent/MX367620B/es active IP Right Grant
- 2014-11-13 PL PL14863015T patent/PL3068770T3/pl unknown
- 2014-11-13 HU HUE19204562A patent/HUE063095T2/hu unknown
- 2014-11-13 MY MYPI2016000911A patent/MY174153A/en unknown
- 2014-11-13 JP JP2016530862A patent/JP6374503B2/ja active Active
- 2014-11-13 MX MX2020009462A patent/MX2020009462A/es unknown
- 2014-11-13 KR KR1020227034215A patent/KR102698200B1/ko active IP Right Grant
- 2014-11-13 CN CN202110168758.6A patent/CN112898210A/zh active Pending
- 2014-11-13 RU RU2016123365A patent/RU2702355C1/ru active
- 2014-11-13 CA CA3207199A patent/CA3207199A1/en active Pending
- 2014-11-13 ES ES14863015T patent/ES2765511T3/es active Active
- 2014-11-13 SG SG10201901578UA patent/SG10201901578UA/en unknown
- 2014-11-13 CA CA2930870A patent/CA2930870C/en active Active
- 2014-11-13 EP EP19204562.3A patent/EP3656764B1/en active Active
- 2014-11-14 AR ARP140104291A patent/AR098427A1/es unknown
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2016
- 2016-05-13 MX MX2019006959A patent/MX2019006959A/es active IP Right Grant
- 2016-05-15 IL IL245636A patent/IL245636B/en active IP Right Grant
- 2016-05-19 ZA ZA2016/03434A patent/ZA201603434B/en unknown
- 2016-09-30 HK HK16111431.6A patent/HK1223102A1/zh unknown
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2017
- 2017-11-20 JP JP2017222867A patent/JP6634428B2/ja active Active
- 2017-11-30 US US15/827,985 patent/US10435378B2/en active Active
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2019
- 2019-04-09 AU AU2019202461A patent/AU2019202461B2/en active Active
- 2019-08-28 JP JP2019155667A patent/JP6857219B2/ja active Active
- 2019-08-29 US US16/555,842 patent/US10858324B2/en active Active
- 2019-12-11 IL IL271331A patent/IL271331B/en active IP Right Grant
- 2019-12-30 HR HRP20192340TT patent/HRP20192340T1/hr unknown
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2020
- 2020-05-11 ZA ZA2020/02611A patent/ZA202002611B/en unknown
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2021
- 2021-02-24 IL IL281072A patent/IL281072B/en unknown
- 2021-03-19 JP JP2021045573A patent/JP7377828B2/ja active Active
- 2021-04-12 AU AU2021202196A patent/AU2021202196A1/en not_active Abandoned
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2022
- 2022-11-24 AU AU2022275477A patent/AU2022275477A1/en not_active Abandoned
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2024
- 2024-08-16 AU AU2024205845A patent/AU2024205845A1/en active Pending
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