SE9401706L - Process för framställning av cephemderivat - Google Patents

Process för framställning av cephemderivat

Info

Publication number: SE9401706L
Authority: SE; Sweden
Prior art keywords: methyl; thiomethyl; formula; image; represents hydrogen
Prior art date: 1991-11-18

Application number

SE9401706A

Other languages

English (en)

Other versions

SE505050C2 (sv

SE9401706D0 (sv

Inventor

Kwang Hyek Lee

Dong Hyun Ko

Young Jin Kim

Myung Xik Xiang

Myeong Sik Yoon

Original Assignee

Cheil Foods & Chem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-18

Filing date

1994-05-18

Publication date

1994-07-07

1994-05-18 Application filed by Cheil Foods & Chem filed Critical Cheil Foods & Chem

1994-05-18 Publication of SE9401706D0 publication Critical patent/SE9401706D0/sv

1994-07-07 Publication of SE9401706L publication Critical patent/SE9401706L/sv

1997-06-16 Publication of SE505050C2 publication Critical patent/SE505050C2/sv

Links

238000000034 method Methods 0.000 title abstract 2
150000001782 cephems Chemical class 0.000 title 1
-1 acetoxy methyl Chemical group 0.000 abstract 2
150000001805 chlorine compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 abstract 2
RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical class S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 abstract 1
VHHHONWQHHHLTI-UHFFFAOYSA-N hexachloroethane Chemical compound ClC(Cl)(Cl)C(Cl)(Cl)Cl VHHHONWQHHHLTI-UHFFFAOYSA-N 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000002184 metal Chemical class 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)

SE9401706A 1991-11-18 1994-05-18 Process för framställning av cephemderivat SE505050C2 (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR1019910020505A KR950014571B1 (ko)	1991-11-18	1991-11-18	세펨 유도체의 제조방법
PCT/KR1992/000041 WO1993010123A1 (en)	1991-11-18	1992-09-04	Process for the preparation of cephem derivatives

Publications (3)

Publication Number	Publication Date
SE9401706D0 SE9401706D0 (sv)	1994-05-18
SE9401706L true SE9401706L (sv)	1994-07-07
SE505050C2 SE505050C2 (sv)	1997-06-16

Family

ID=19322986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9401706A SE505050C2 (sv)	1991-11-18	1994-05-18	Process för framställning av cephemderivat

Country Status (13)

Country	Link
US (1)	US5317099A (sv)
EP (1)	EP0613480B1 (sv)
JP (1)	JPH0811755B2 (sv)
KR (1)	KR950014571B1 (sv)
AT (1)	AT403048B (sv)
CH (1)	CH684091A5 (sv)
DE (2)	DE4293959T1 (sv)
DK (1)	DK56694A (sv)
ES (1)	ES2070101B1 (sv)
GB (1)	GB2275927B (sv)
NL (1)	NL9220025A (sv)
SE (1)	SE505050C2 (sv)
WO (1)	WO1993010123A1 (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5402609A (en) *	1992-08-13	1995-04-04	Kelley, Jr.; Michael L.	Concrete building block system
TW369530B (en) *	1993-06-10	1999-09-11	Lucky Ltd	Process for preparing cephalosporin compounds from reactive organic acid derivatives
KR100197788B1 (ko) *	1995-06-30	1999-06-15	김충환	세펨 유도체의 제조방법
IN181459B (sv) *	1995-12-26	1998-06-20	Lupin Lab Ltd
EP1704153A2 (en) *	2004-01-16	2006-09-27	Wockhardt Limited	Improved process for the production of cefotaxime sodium
CN108383857B (zh) *	2018-05-04	2021-02-05	山东四环药业股份有限公司	一种盐酸头孢甲肟的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4196205A (en) *	1976-01-23	1980-04-01	Roussel Uclaf	3-Acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives
DE2760123C2 (de) *	1976-01-23	1986-04-30	Roussel-Uclaf, Paris	7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4166115A (en) *	1976-04-12	1979-08-28	Fujisawa Pharmaceutical Co., Ltd.	Syn 7-oxoimino substituted derivatives of cephalosporanic acid
US4304770A (en) *	1976-04-12	1981-12-08	Fujisawa Pharmaceutical Co., Ltd.	Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US4331664A (en) *	1976-04-12	1982-05-25	Fujisawa Pharmaceutical Co., Ltd.	Syn isomer of 7-[2-cyclo(lower) alkoxyimino-2-(2-amino-or substituted aminothiazol-4-yl)acetamido]-3-lower alkanoyloxymethyl or heterocyclicthiomethyl-3-cephem-4-carboxylic acid compounds
DE2760484C2 (sv) *	1976-04-14	1992-12-03	Takeda Chemical Industries, Ltd., Osaka, Jp
US4370326A (en) *	1977-09-13	1983-01-25	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds and composition
DE2758000A1 (de) *	1977-12-24	1979-07-05	Hoechst Ag	Verfahren zur herstellung von penicillinen und cephalosporinen
MC1259A1 (fr) *	1978-05-30	1980-01-14	Hoffmann La Roche	Derives acyles
CH641468A5 (de) *	1978-05-30	1984-02-29	Hoffmann La Roche	Cephemderivate.
GB2025933B (en) *	1978-06-13	1982-10-27	Fujisawa Pharmaceutical Co	Cephem and cepham compounds
FR2462439A1 (fr) *	1979-07-26	1981-02-13	Roussel Uclaf	Nouveau procede de preparation de produits derives de l'acide 7-/(2-aryl) 2-hydroxyimino acetamido/cephalosporanique
CY1365A (en) *	1980-03-28	1987-08-07	Biochemie Gmbh	New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
KR870001332B1 (ko) *	1984-09-27	1987-07-18	한미약품공업 주식회사	세펨 유도체의 간단한 제조방법
CN1022837C (zh) *	1988-03-16	1993-11-24	卫材株式会社	制备头孢烯衍生物的方法
IT1234385B (it) *	1989-05-23	1992-05-18	Sbd Synthetic And Biolog Devel	Procedimento migliorato per la produzione di una sostanza antibiotica appartenente al gruppo delle cefalosporine

1991
- 1991-11-18 KR KR1019910020505A patent/KR950014571B1/ko not_active IP Right Cessation
1992
- 1992-09-04 NL NL9220025A patent/NL9220025A/nl not_active Application Discontinuation
- 1992-09-04 WO PCT/KR1992/000041 patent/WO1993010123A1/en active IP Right Grant
- 1992-09-04 AT AT0903092A patent/AT403048B/de not_active IP Right Cessation
- 1992-09-04 DE DE4293959T patent/DE4293959T1/de active Pending
- 1992-09-04 CH CH2208/93A patent/CH684091A5/de not_active IP Right Cessation
- 1992-09-04 EP EP92919241A patent/EP0613480B1/en not_active Expired - Lifetime
- 1992-09-04 GB GB9409758A patent/GB2275927B/en not_active Expired - Fee Related
- 1992-09-04 DE DE4293959A patent/DE4293959C2/de not_active Expired - Fee Related
- 1992-09-04 JP JP5509158A patent/JPH0811755B2/ja not_active Expired - Fee Related
- 1992-10-13 US US07/959,359 patent/US5317099A/en not_active Expired - Lifetime
1993
- 1993-07-16 ES ES09350013A patent/ES2070101B1/es not_active Expired - Fee Related
1994
- 1994-05-18 SE SE9401706A patent/SE505050C2/sv not_active IP Right Cessation
- 1994-05-18 DK DK056694A patent/DK56694A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1993010123A1 (en)	1993-05-27
JPH0811755B2 (ja)	1996-02-07
KR930010043A (ko)	1993-06-21
NL9220025A (nl)	1994-12-01
CH684091A5 (de)	1994-07-15
SE505050C2 (sv)	1997-06-16
ATA903092A (de)	1997-03-15
US5317099A (en)	1994-05-31
EP0613480A1 (en)	1994-09-07
JPH07501072A (ja)	1995-02-02
EP0613480B1 (en)	1999-03-31
ES2070101B1 (es)	1996-02-16
DK56694A (da)	1994-05-18
ES2070101A1 (es)	1995-05-16
GB2275927B (en)	1995-10-04
DE4293959C2 (de)	1996-08-29
GB2275927A (en)	1994-09-14
DE4293959T1 (de)	1995-01-26
AT403048B (de)	1997-10-27
GB9409758D0 (en)	1994-07-20
KR950014571B1 (ko)	1995-12-08
SE9401706D0 (sv)	1994-05-18

Legal Events

Date	Code	Title	Description
2010-05-05	NUG	Patent has lapsed

Publication	Publication Date	Title
US4410458A (en)	1983-10-18	Process for providing an oxidized penam
SE8403896L (sv)	1985-01-30	Antibiotika
NO844006L (no)	1985-04-09	Cefalosporinderivater og fremgangsmaate til deres fremstilling
KR870001986B1 (ko)	1987-10-24	세팔로스포린 유도체의 제조방법
SE9401706L (sv)	1994-07-07	Process för framställning av cephemderivat
KR850002992A (ko)	1985-05-28	3-비사이클릭피리디늄-메틸 세파로스포린의 제조방법
US4577014A (en)	1986-03-18	Thieno and furopyridinium-substituted cephalosporins
US4017488A (en)	1977-04-12	Process for preparing 7β-acylamino-7α-alkoxycephalosporins
CA1092096A (en)	1980-12-23	Oxygen analogs of cephalosporins
AU1866388A (en)	1989-01-12	New process for the preparation of cephem compounds and new cephalosporin derivatives
US4145540A (en)	1979-03-20	7β-Phosphoramido-7α-methoxycephalosporanic acid derivatives
US3799924A (en)	1974-03-26	Ester cleavage process
AU3029189A (en)	1989-09-07	Process for preparing 2 alpha-methyl-2 beta - (1,2,3- triazol-1-yl) methylpenam- 3 alpha - carboxylic acid derivatives
US4980464A (en)	1990-12-25	Method for production of cephalosporin compounds
KR860004861A (ko)	1986-07-14	아미노티아졸 아세트산 유도체의 제조방법
US4943631A (en)	1990-07-24	Process for cephem compounds
ES438429A1 (es)	1977-02-16	Procedimiento para la preparacion de compuestos cefalospori-nas.
ES8703401A1 (es)	1987-02-16	Procedimiento para la obtencion de esteres del acido 4-aci- loxi-3-oxo-butirico
US4267340A (en)	1981-05-12	Disulfide substituted oxazetidine derivatives
CA1067892A (en)	1979-12-11	Iodo compounds
GB2165245A (en)	1986-04-09	Chemical compounds
KR930016427A (ko)	1993-08-26	세프트리악손 디소디움염 헤미헵타하이드레이트의 제조방법
US3867378A (en)	1975-02-18	Preparation of 7-acylamido-7-methoxy-3-substituted methyl-3(or 2)-cephem-4-carboxylic acid and its s-oxides
ES2002912A6 (es)	1988-10-01	Procedimiento para la produccion de antibioticos de cefalosporina
CA1065852A (en)	1979-11-06	PROCESS FOR PREPARING 7.beta.-ACYLAMINO-7.alpha.-ALKOXYCEPHALOSPORINS OR 6.beta.-ACYLAMINO-6.alpha.-ALKOXYPENICILLINS