SE8300736D0 - Novel pharmacologically active compounds - Google Patents
Novel pharmacologically active compoundsInfo
- Publication number
- SE8300736D0 SE8300736D0 SE8300736A SE8300736A SE8300736D0 SE 8300736 D0 SE8300736 D0 SE 8300736D0 SE 8300736 A SE8300736 A SE 8300736A SE 8300736 A SE8300736 A SE 8300736A SE 8300736 D0 SE8300736 D0 SE 8300736D0
- Authority
- SE
- Sweden
- Prior art keywords
- active compounds
- pharmacologically active
- novel pharmacologically
- novel
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8300736A SE8300736D0 (sv) | 1983-02-11 | 1983-02-11 | Novel pharmacologically active compounds |
DE3404610A DE3404610A1 (de) | 1983-02-11 | 1984-02-09 | Benzimidazolderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel |
SE8400688A SE8400688L (sv) | 1983-02-11 | 1984-02-09 | Nya farmakologiskt aktiva foreningar |
CH660/84A CH666892A5 (de) | 1983-02-11 | 1984-02-10 | Pharmakologisch aktive verbindungen, die zur verhuetung und behandlung von magengeschwueren verwendbar sind. |
NO840504A NO840504L (no) | 1983-02-11 | 1984-02-10 | Nye farmakologisk aktive forbindelser |
ZA841011A ZA841011B (en) | 1983-02-11 | 1984-02-10 | Novel pharmacologically active compounds |
NL8400446A NL8400446A (nl) | 1983-02-11 | 1984-02-10 | Farmaceutisch werkzame verbindingen, werkwijzen ter bereiding ervan alsmede samenstellingen, die deze verbindingen bevatten. |
BE0/212366A BE898880A (fr) | 1983-02-11 | 1984-02-10 | Nouveaux benzimidazoles, preparations pharmaceutiques qui les contiennent et leur preparation |
FI840547A FI840547A (fi) | 1983-02-11 | 1984-02-10 | Nya farmakologiskt aktiva foereningar. |
AT0043584A AT386825B (de) | 1983-02-11 | 1984-02-10 | Verfahren zur herstellung von neuen benzimidazolderivaten und von deren salzen |
FR8402093A FR2543551B1 (fr) | 1983-02-11 | 1984-02-10 | Benzimidapoles substitues, procede pour leur preparation et compositions pharmaceutiques les contenant, inhibant la secretion d'acide gastrique ou exercant un effet cytoprotecteur du tube digestif |
JP59022067A JPS59181277A (ja) | 1983-02-11 | 1984-02-10 | 新規な薬理学的に活性な化合物 |
GB08403540A GB2134523B (en) | 1983-02-11 | 1984-02-10 | Novel pharmacologically active compounds |
IT47675/84A IT1177553B (it) | 1983-02-11 | 1984-02-10 | Composti farmacologicamente attivi per il trattamento di affezioni gastrointestinali e procedimento di preparazione |
AU24456/84A AU578891B2 (en) | 1983-02-11 | 1984-02-10 | Substituted 2-pyridylobenzimidazole derivatives |
DK59184A DK59184A (da) | 1983-02-11 | 1984-02-10 | Farmakologisk virksomme forbindelser og terapeutisk acceptable salte deraf |
LU85209A LU85209A1 (de) | 1983-02-11 | 1984-02-10 | Benzimidazoles substitues,procede pour leur preparation et compositions pharmaceutiques les contenant,inhibant la secretion d'acide gastrique ou exercant un effet cytoprotecteur du tube digestif |
NZ207102A NZ207102A (en) | 1983-02-11 | 1984-02-10 | Benzimidazole derivatives and pharmaceutical compositions |
GB868610503A GB8610503D0 (en) | 1983-02-11 | 1986-04-29 | Pyridyl alkylthiobenzimidazole derivatives |
GB08610790A GB2174988B (en) | 1983-02-11 | 1986-05-02 | Intermediates for pyridyl alkylthio-benzimidazole derivatives |
SE8700498A SE8700498D0 (sv) | 1983-02-11 | 1987-02-10 | Novel pharmaceologically active compounds |
SE8700499A SE8700499L (sv) | 1983-02-11 | 1987-02-10 | Nya farmakologiskt aktiva foreningar |
NO882001A NO882001D0 (no) | 1983-02-11 | 1988-05-06 | Analogifremgangsmaate til fremstilling av farmakologisk aktive forbindelser. |
US07/408,719 US5039806A (en) | 1983-02-11 | 1989-09-18 | Novel pharmacologically active compound pyridyl methylsulfinyl benzimidazole |
CY1555A CY1555A (en) | 1983-02-11 | 1991-03-22 | Pyridyl alkylthio-benzimidazole derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8300736A SE8300736D0 (sv) | 1983-02-11 | 1983-02-11 | Novel pharmacologically active compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SE8300736D0 true SE8300736D0 (sv) | 1983-02-11 |
Family
ID=20349994
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8300736A SE8300736D0 (sv) | 1983-02-11 | 1983-02-11 | Novel pharmacologically active compounds |
SE8700498A SE8700498D0 (sv) | 1983-02-11 | 1987-02-10 | Novel pharmaceologically active compounds |
SE8700499A SE8700499L (sv) | 1983-02-11 | 1987-02-10 | Nya farmakologiskt aktiva foreningar |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8700498A SE8700498D0 (sv) | 1983-02-11 | 1987-02-10 | Novel pharmaceologically active compounds |
SE8700499A SE8700499L (sv) | 1983-02-11 | 1987-02-10 | Nya farmakologiskt aktiva foreningar |
Country Status (19)
Country | Link |
---|---|
US (1) | US5039806A (sv) |
JP (1) | JPS59181277A (sv) |
AT (1) | AT386825B (sv) |
AU (1) | AU578891B2 (sv) |
BE (1) | BE898880A (sv) |
CH (1) | CH666892A5 (sv) |
CY (1) | CY1555A (sv) |
DE (1) | DE3404610A1 (sv) |
DK (1) | DK59184A (sv) |
FI (1) | FI840547A (sv) |
FR (1) | FR2543551B1 (sv) |
GB (3) | GB2134523B (sv) |
IT (1) | IT1177553B (sv) |
LU (1) | LU85209A1 (sv) |
NL (1) | NL8400446A (sv) |
NO (1) | NO840504L (sv) |
NZ (1) | NZ207102A (sv) |
SE (3) | SE8300736D0 (sv) |
ZA (1) | ZA841011B (sv) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
CA1259070A (en) * | 1983-07-01 | 1989-09-05 | Upjohn Company (The) | Substituted 2-¬monoannelated(3,4-,4,5-, and 5,6-)- pyridylalkylenesulfinyl|-benzimidazoles |
US5077407A (en) * | 1983-07-01 | 1991-12-31 | The Upjohn Company | Substituted 2-[monoannelated (3,4-,4,5-, and 5,6-) pyridylalkylenesulfinyl]benzimidazoles |
US4575554A (en) * | 1983-12-05 | 1986-03-11 | The Upjohn Company | Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents |
ZW4585A1 (en) * | 1984-04-19 | 1985-11-20 | Hoffmann La Roche | Imidazole derivatives |
CA1341314C (en) | 1984-07-06 | 2001-11-06 | David Cox | Derivatives of benzimidazole, benzothiazole and benzoxazole |
SE8404065D0 (sv) * | 1984-08-10 | 1984-08-10 | Haessle Ab | Novel biologically active compounds |
JPS6150979A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
JPS6150978A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
US4619997A (en) * | 1984-09-06 | 1986-10-28 | The Upjohn Company | Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents |
AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
KR890000387B1 (ko) * | 1984-09-24 | 1989-03-16 | 디 엎존 캄파니 | 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법 |
IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
DE3509333A1 (de) * | 1985-03-15 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Substituierte benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer |
AU5768886A (en) | 1985-05-24 | 1986-11-27 | G.D. Searle & Co. | 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines |
US5869513A (en) * | 1985-05-24 | 1999-02-09 | G. D. Searle & Co. | 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines |
US4738975A (en) * | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
DK337086A (da) * | 1985-08-12 | 1987-02-13 | Hoffmann La Roche | Benzimidazolderivater |
SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
US5433959A (en) | 1986-02-13 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
US6749864B2 (en) | 1986-02-13 | 2004-06-15 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
CA1327010C (en) * | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
EP0234485B1 (de) * | 1986-02-20 | 1992-04-01 | Hoechst Aktiengesellschaft | Substituierte Thienoimidazol-Derivate, Verfahren zu ihrer Herstellung, sie enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Magensäuresekretionshemmer |
JPS62201884A (ja) * | 1986-02-28 | 1987-09-05 | Tokyo Tanabe Co Ltd | ベンズイミダゾール誘導体及びその製造法 |
ATE56717T1 (de) * | 1986-07-01 | 1990-10-15 | Shionogi & Co | Substituierte isoquinolinderivate und antiulcusmittel. |
US4772619A (en) * | 1986-07-17 | 1988-09-20 | G. D. Searle & Co. | [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines |
US4687775A (en) * | 1986-07-17 | 1987-08-18 | G. D. Searle & Co. | 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles |
US4721718A (en) * | 1986-08-18 | 1988-01-26 | G. D. Searle & Co. | 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers |
SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
ATE103912T1 (de) * | 1986-11-13 | 1994-04-15 | Eisai Co Ltd | Pyridin-derivate, deren pharmazeutische zusammenstellungen, deren anwendung fuer die herstellung von arzneimitteln mit therapeutischem oder vorbeugendem wert und verfahren zu deren herstellung. |
FI90544C (sv) * | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Förfarande för framställning såsom läkemedel användbara 2-pyridin-2-yl-metyltio- och sulfinyl-1H-benzimidazolderivater |
NZ222495A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | Benzimidazole derivatives and pharmaceutical compositions |
US5026560A (en) * | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
US4942245A (en) * | 1987-04-20 | 1990-07-17 | Kyorin Pharmaceutical Co., Ltd. | Benzimidazole Derivatives |
US4839365A (en) * | 1987-05-19 | 1989-06-13 | Shinogi & Co., Ltd. | Thienopyridine derivatives useful in treating gastric ulcers |
JP2718945B2 (ja) * | 1987-06-17 | 1998-02-25 | エーザイ株式会社 | ピリジン誘導体及びそれを含有する潰瘍治療剤 |
FI96860C (sv) * | 1987-06-17 | 1996-09-10 | Eisai Co Ltd | Ett analogiförfarande för framställning av ett som läkemedel avsett pyridinderivat |
US4920230A (en) * | 1987-06-29 | 1990-04-24 | Takeda Chemical Industries, Ltd. | Method of producing nitrogen-containing heteroaromatic compounds having an alkoxy group |
WO1989000566A1 (en) * | 1987-07-21 | 1989-01-26 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridine compounds and medicinal use thereof |
WO1990003373A1 (en) * | 1988-09-20 | 1990-04-05 | Hisamitsu Pharmaceutical Co., Inc. | NOVEL DIBENZ[b,e]OXEPIN DERIVATIVES |
AT391693B (de) * | 1988-11-15 | 1990-11-12 | Cl Pharma | Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer |
EG19302A (en) * | 1988-12-22 | 1994-11-30 | Haessle Ab | Compound with gastric acid inhibitory effect and process for its preparation |
US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
SE9002206D0 (sv) | 1990-06-20 | 1990-06-20 | Haessle Ab | New compounds |
EP0567643A4 (en) * | 1991-01-16 | 1995-07-19 | Yoshitomi Pharmaceutical | PYRIDINE COMPOUND USED AS A SELECTIVE DRUG AND NEW PYRIDINE COMPOUND. |
ES2037609B1 (es) * | 1991-12-02 | 1994-04-01 | Techquin Etablissment | Procedimiento para la obtencion del 2-(((3-metil-4-(2,2,2-trifluroetoxi)-2-piridinil)-metil)sulfinil)-1h-benzimidazol. |
ES2037608B1 (es) * | 1991-12-02 | 1994-04-01 | Techquin Etablissment | Procedimiento para la obtencion del 2 (((3-metil-4-(2,2,2,-trifluoroetoxi)-2-piridinil)-metil)sulfinil)-1h-benzimidazol". |
US5504082A (en) * | 1992-06-01 | 1996-04-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridine compound and pharmaceutical compostions |
KR950701921A (ko) * | 1992-06-01 | 1995-05-17 | 고야 다다시 | 피리딘 화합물 및 이의 제약학적 용도(pyridine compound and medicinal use thereof) |
KR0144793B1 (ko) * | 1992-07-08 | 1998-07-15 | 제임스 클리프튼 보올딩 | 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸 |
HU226778B1 (en) * | 1992-07-28 | 2009-10-28 | Astra Ab | Injection and injection kit containing omeprazole and its analogs |
TW280770B (sv) | 1993-10-15 | 1996-07-11 | Takeda Pharm Industry Co Ltd | |
CA2178000A1 (en) | 1993-12-01 | 1995-06-08 | Jorg Senn-Bilfinger | Substituted aminoalkylaminopyridines |
KR0142815B1 (ko) * | 1994-12-02 | 1998-07-15 | 정도언 | 신규한 5-피롤릴-6-할로게노-2피리딜메틸설피닐벤즈이미다졸 유도체 |
KR0179401B1 (ko) * | 1994-02-28 | 1999-03-20 | 송택선 | 신규한 5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸 유도체 |
WO1995029897A1 (en) * | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
HUT76054A (en) * | 1994-06-10 | 1997-06-30 | Byk Gulden Lomberg Chem Fab | Thiopyridines, pharmaceutical compositions containing them, process for producing them and their use in the control of helicobacter bacteria |
NZ318501A (en) * | 1995-09-21 | 1999-06-29 | Pharma Pass Llc | Novel composition containing an acid-labile omeprazole and process for its preparation |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US7230014B1 (en) | 1997-10-14 | 2007-06-12 | Eisai Co., Ltd. | Pharmaceutical formulation comprising glycine as a stabilizer |
JP3746167B2 (ja) | 1998-05-18 | 2006-02-15 | 武田薬品工業株式会社 | 医薬製剤 |
US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
ID28273A (id) * | 1998-08-10 | 2001-05-10 | Partnership Of Michael E Garst | Prodrug inhibitor pompa proton |
WO2000027841A1 (en) * | 1998-11-06 | 2000-05-18 | Dong-A Pharmaceutical Co., Ltd. | Method of preparing sulfide derivatives |
US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
US6262085B1 (en) * | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
EP1595879A3 (en) * | 1999-08-26 | 2010-01-27 | aaiPharma Inc. | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
RU2263673C2 (ru) * | 1999-08-26 | 2005-11-10 | ааиФАРМА ИНК. | Алкоксизамещенные бензимидазольные соединения, содержащие их фармацевтические препараты и способ их применения |
US6369087B1 (en) * | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
MXPA02008232A (es) | 2000-02-24 | 2004-04-05 | Kopran Res Lab Ltd | Derivados de benximidazol contra ulceras, estables al acido, administrables por via oral. |
US6544556B1 (en) * | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
AU2001296908A1 (en) * | 2000-09-29 | 2002-04-08 | Geneva Pharmaceuticals, Inc. | Proton pump inhibitor formulation |
KR20040029966A (ko) * | 2001-02-02 | 2004-04-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 치환된 2-(2-피리딜메틸)설피닐-1h-벤즈이미다졸 |
US6903126B2 (en) * | 2001-07-09 | 2005-06-07 | Schering Ag | 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives |
DE10135050A1 (de) * | 2001-07-09 | 2003-02-06 | Schering Ag | 1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
US20040248941A1 (en) * | 2001-09-25 | 2004-12-09 | Keiji Kamiyama | Benzimidazone compound, process for producing the same, and use thereof |
US20040006111A1 (en) * | 2002-01-25 | 2004-01-08 | Kenneth Widder | Transmucosal delivery of proton pump inhibitors |
US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
US7410981B2 (en) * | 2002-06-14 | 2008-08-12 | Takeda Pharmaceutical Company Limited | Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. peptic ulcers |
EP1572680A2 (en) | 2002-12-19 | 2005-09-14 | Eva Pharmaceutical Industries Ltd. | Solid states of pantoprazole sodium, known pantoprazole sodium hydrates, processes for their preparation. |
ES2324665T3 (es) * | 2003-01-15 | 2009-08-12 | Cipla Limited | Proceso farmaceutico y compuestos preparados a traves del mismo. |
CA2517005A1 (en) * | 2003-02-20 | 2004-09-02 | Santarus, Inc. | A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
MXPA05013316A (es) | 2003-06-10 | 2006-03-17 | Teva Pharma | Proceso para preparar bencimidazoles 2[-(piridinil)metil]sulfinil-sustituidos y derivados clorados novedosos de pantoprazol. |
PL379542A1 (pl) * | 2003-07-15 | 2006-10-02 | Allergan, Inc. | Sposób wytwarzania izomerycznie czystych proleków inhibitorów pompy protonowej |
US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
AR046893A1 (es) * | 2003-12-16 | 2005-12-28 | Altana Pharma Ag | Bencimidazoles triciclicos |
TW200606163A (en) | 2004-04-22 | 2006-02-16 | Eisai Co Ltd | Imidazopyridine compound |
US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
US8592598B2 (en) | 2004-09-13 | 2013-11-26 | Takeda Pharmaceutical Company Limited | Method of producing a crystal of an imidazole compound |
US20070015782A1 (en) * | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
MY151167A (en) * | 2005-04-15 | 2014-04-30 | Eisai R&D Man Co Ltd | Benzimidazole compound |
US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
JP5053865B2 (ja) | 2005-12-28 | 2012-10-24 | 武田薬品工業株式会社 | 口腔内崩壊性固形製剤の製造法 |
WO2007122686A1 (ja) * | 2006-04-14 | 2007-11-01 | Eisai R & D Management Co., Ltd. | ベンズイミダゾール化合物 |
US7786309B2 (en) * | 2006-06-09 | 2010-08-31 | Apotex Pharmachem Inc. | Process for the preparation of esomeprazole and salts thereof |
JP5492417B2 (ja) * | 2006-10-13 | 2014-05-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 胃酸分泌抑制作用を有するベンズイミダゾール化合物 |
AU2007335663B2 (en) | 2006-12-18 | 2011-12-15 | Link Genomics, Inc. | Helicobacter pylori eradicating agent having inhibitory activity on gastric acid secretion |
ZA200904573B (en) | 2006-12-22 | 2010-09-29 | Ironwood Pharmaceuticals Inc | Compositions comprising bile acid sequestrants for treating esophageal disorders |
CN102140099A (zh) * | 2010-02-02 | 2011-08-03 | 山东轩竹医药科技有限公司 | 新的吡啶衍生物 |
WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
CN105338958A (zh) | 2013-01-15 | 2016-02-17 | 铁木医药有限公司 | 胆汁酸螯合剂的胃内滞留缓释口服剂型 |
WO2016126625A1 (en) | 2015-02-03 | 2016-08-11 | Ironwood Pharmaceuticals, Inc. | Methods of treating upper gastrointestinal disorders in ppi refractory gerd |
IL265108B2 (en) * | 2016-09-14 | 2024-03-01 | Yufeng Jane Tseng | Novel mutated benzimidazoles as D-amino acid oxidase (DAAO) inhibitors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1013069B (it) * | 1973-03-29 | 1977-03-30 | Du Pont | Processo di preparazione di 2 benzimidazoltiolo |
US3857769A (en) * | 1973-11-08 | 1974-12-31 | Scm Corp | Photopolymerizable coating compositions and process for making same which contains a thioxanthone and an activated halogenated azine compound as sensitizers |
SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
US4045564A (en) * | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
HU178454B (en) * | 1979-07-02 | 1982-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new isoquinoline derivatives containing sulphur |
NL8002540A (nl) * | 1979-05-09 | 1980-11-11 | Rhone Poulenc Ind | Nieuwe isochinoline derivaten, werkwijzen ter bereiding ervan en farmaceutische preparaten, die de nieuwe derivaten bevatten. |
US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
IL66340A (en) * | 1981-08-13 | 1986-08-31 | Haessle Ab | Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation |
US4472409A (en) * | 1981-11-05 | 1984-09-18 | Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung | 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects |
SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
JPS6150979A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
-
1983
- 1983-02-11 SE SE8300736A patent/SE8300736D0/sv unknown
-
1984
- 1984-02-09 DE DE3404610A patent/DE3404610A1/de not_active Withdrawn
- 1984-02-10 AT AT0043584A patent/AT386825B/de not_active IP Right Cessation
- 1984-02-10 NL NL8400446A patent/NL8400446A/nl not_active Application Discontinuation
- 1984-02-10 FR FR8402093A patent/FR2543551B1/fr not_active Expired
- 1984-02-10 FI FI840547A patent/FI840547A/fi not_active Application Discontinuation
- 1984-02-10 NO NO840504A patent/NO840504L/no unknown
- 1984-02-10 IT IT47675/84A patent/IT1177553B/it active
- 1984-02-10 GB GB08403540A patent/GB2134523B/en not_active Expired
- 1984-02-10 ZA ZA841011A patent/ZA841011B/xx unknown
- 1984-02-10 JP JP59022067A patent/JPS59181277A/ja active Pending
- 1984-02-10 CH CH660/84A patent/CH666892A5/de not_active IP Right Cessation
- 1984-02-10 BE BE0/212366A patent/BE898880A/fr unknown
- 1984-02-10 DK DK59184A patent/DK59184A/da not_active Application Discontinuation
- 1984-02-10 AU AU24456/84A patent/AU578891B2/en not_active Ceased
- 1984-02-10 LU LU85209A patent/LU85209A1/fr unknown
- 1984-02-10 NZ NZ207102A patent/NZ207102A/en unknown
-
1986
- 1986-04-29 GB GB868610503A patent/GB8610503D0/en active Pending
- 1986-05-02 GB GB08610790A patent/GB2174988B/en not_active Expired
-
1987
- 1987-02-10 SE SE8700498A patent/SE8700498D0/sv not_active Application Discontinuation
- 1987-02-10 SE SE8700499A patent/SE8700499L/sv not_active Application Discontinuation
-
1989
- 1989-09-18 US US07/408,719 patent/US5039806A/en not_active Expired - Fee Related
-
1991
- 1991-03-22 CY CY1555A patent/CY1555A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DK59184A (da) | 1984-08-12 |
SE8700498L (sv) | 1987-02-10 |
IT8447675A0 (it) | 1984-02-10 |
LU85209A1 (de) | 1985-09-12 |
CH666892A5 (de) | 1988-08-31 |
GB8403540D0 (en) | 1984-03-14 |
AU578891B2 (en) | 1988-11-10 |
DK59184D0 (da) | 1984-02-10 |
GB8610503D0 (en) | 1986-06-04 |
SE8700499D0 (sv) | 1987-02-10 |
AT386825B (de) | 1988-10-25 |
NL8400446A (nl) | 1984-09-03 |
GB2134523A (en) | 1984-08-15 |
NZ207102A (en) | 1987-09-30 |
US5039806A (en) | 1991-08-13 |
NO840504L (no) | 1984-08-13 |
FI840547A0 (fi) | 1984-02-10 |
DE3404610A1 (de) | 1984-08-16 |
GB2134523B (en) | 1987-08-12 |
JPS59181277A (ja) | 1984-10-15 |
SE8700498D0 (sv) | 1987-02-10 |
ATA43584A (de) | 1988-03-15 |
GB8610790D0 (en) | 1986-06-11 |
AU2445684A (en) | 1984-08-16 |
GB2174988A (en) | 1986-11-19 |
BE898880A (fr) | 1984-08-10 |
FR2543551A1 (fr) | 1984-10-05 |
GB2174988B (en) | 1987-08-26 |
FR2543551B1 (fr) | 1987-08-21 |
ZA841011B (en) | 1984-09-26 |
IT1177553B (it) | 1987-08-26 |
FI840547A (fi) | 1984-08-12 |
CY1555A (en) | 1991-03-22 |
SE8700499L (sv) | 1987-02-10 |
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