SE7703223L - 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav - Google Patents

2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav

Info

Publication number
SE7703223L
SE7703223L SE7703223A SE7703223A SE7703223L SE 7703223 L SE7703223 L SE 7703223L SE 7703223 A SE7703223 A SE 7703223A SE 7703223 A SE7703223 A SE 7703223A SE 7703223 L SE7703223 L SE 7703223L
Authority
SE
Sweden
Prior art keywords
alkyl
hydrogen
pyrazino
quinoxalin
tetrahydro
Prior art date
Application number
SE7703223A
Other languages
English (en)
Inventor
M E Freed
J R Potoski
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of SE7703223L publication Critical patent/SE7703223L/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE7703223A 1976-03-22 1977-03-21 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav SE7703223L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/668,872 US4032639A (en) 1976-03-22 1976-03-22 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension

Publications (1)

Publication Number Publication Date
SE7703223L true SE7703223L (sv) 1977-09-23

Family

ID=24684079

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7703223A SE7703223L (sv) 1976-03-22 1977-03-21 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav

Country Status (13)

Country Link
US (1) US4032639A (sv)
JP (1) JPS52114000A (sv)
AT (1) AT357540B (sv)
AU (1) AU506308B2 (sv)
BE (1) BE852737A (sv)
CA (1) CA1093557A (sv)
DE (1) DE2712573A1 (sv)
DK (1) DK122377A (sv)
FR (1) FR2345450A1 (sv)
GB (3) GB1538987A (sv)
NL (1) NL7702920A (sv)
SE (1) SE7703223L (sv)
ZA (1) ZA771381B (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182872A (en) * 1976-03-22 1980-01-08 American Home Products Corporation 4-(Lower)alkyl-1-(o-nitrophenyl)piperazine-2-carboxylic acid chemical intermediates
US4182869A (en) * 1976-03-22 1980-01-08 American Home Products Corporation 4-Carbobenzoxypiperazine-2-carboxylic acid chemical intermediate
US4089958A (en) * 1976-12-20 1978-05-16 American Home Products Corporation 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof
US4225713A (en) * 1977-08-03 1980-09-30 Freed Meier E Tetrahydro(1H)pyrazino(1,2-A)azaquinoxalin-5(6H)-ones and derivatives thereof
US4203987A (en) * 1979-05-21 1980-05-20 American Home Products Corporation 3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-ones
US6369057B1 (en) 1991-04-15 2002-04-09 Aventis Pharma Deutschland Gmbh Quinoxalines, processes for their preparation and their use
EP0509398B1 (de) * 1991-04-15 2001-09-19 Aventis Pharma Deutschland GmbH Chinoxaline, Verfahren zu ihrer Herstellung und ihre Verwendung
US5753653A (en) 1995-12-08 1998-05-19 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
IL138027A (en) * 1995-12-08 2004-08-31 Agouron Pharma Intermediates for the preparation and preparation of metalloproteinase inhibitors
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6476032B2 (en) * 1998-12-17 2002-11-05 Wyeth 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives
US6372745B1 (en) * 1999-12-06 2002-04-16 American Home Products Corporation 2,3,4,4A-tetrahydro-1H-pyrazino[1,2-A]quinoxalin-5(6H)one derivatives
BR9916326A (pt) * 1998-12-17 2001-10-02 American Home Prod Derivados de 2,3,4,4a-tetrahidro-1h-pirazino(1,2-a)quinoxalin-5-(6h) ona sendo agonistas de 5ht2c
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US20060211700A1 (en) * 2005-03-21 2006-09-21 Alcon, Inc. (R)-8,9-dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoxalin-5-one for controlling IOP and treating glaucoma
HUE036407T2 (hu) 2011-12-14 2018-07-30 Kumiai Chemical Industry Co Difenilamin vegyület és eljárás elõállítására
JPWO2014208296A1 (ja) * 2013-06-25 2017-02-23 イハラケミカル工業株式会社 ニトロベンゼン化合物を製造する方法
CN114096533B (zh) * 2019-09-10 2024-03-08 四川科伦博泰生物医药股份有限公司 一种三并环类化合物，包含其的药物组合物，其制备方法及其用途

Also Published As

Publication number Publication date
GB1538987A (en) 1979-01-24
DK122377A (da) 1977-09-23
AU2304877A (en) 1978-09-14
DE2712573A1 (de) 1977-09-29
ATA189377A (de) 1979-12-15
FR2345450A1 (fr) 1977-10-21
CA1093557A (en) 1981-01-13
GB1538988A (en) 1979-01-24
BE852737A (fr) 1977-09-22
JPS52114000A (en) 1977-09-24
NL7702920A (nl) 1977-09-26
ZA771381B (en) 1978-10-25
FR2345450B1 (sv) 1980-05-09
US4032639A (en) 1977-06-28
GB1538986A (en) 1979-01-24
AU506308B2 (en) 1979-12-20
AT357540B (de) 1980-07-10

Similar Documents

Publication Publication Date Title
SE7703223L (sv) 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav
SE8601907L (sv) Antitrombogena och kardiotoniska imidazokinoliner
DK217184A (da) Fluoralkoxyforbindelser
GR69233B (sv)
SE7906722L (sv) Merkaptoacylderivat av substituerade proliner
ATE24001T1 (de) Substituierte 1-hydroxyethyl-triazolyl-derivate.
IE820401L (en) N-£4-(indolyl)-piperidino-alkyl|-benzimidazolines
IL66152A0 (en) Pyridinocarbinols,their preparation and their use as fungicides
ES477803A1 (es) Procedimiento para la obtencion de compuestos de fenilaceta-mida.
SE7901510L (sv) Halogensubstituerade merkaptoacylaminosyror
SE7906507L (sv) Fenyl-1-piperazinderivat
DK316589A (da) Substituerede azacyclohexylderivater af rifamyciner
ES480391A1 (es) Un procedimiento para la preparacion de derivados de difeni-lamina.
GB2128190B (en) Chemical compounds
FI791996A (fi) Nya imidazo/1,2-a/imidazoler deras syraadditionssalter dessa innehaollande laekemedel och foerfarande foer deras framstaellning
DE3464602D1 (en) 4-alkylimidazole derivatives, their preparation and their application
FI803887L (fi) Nya substituerade 2-fenylamino-imidazoliner-(2) deras syraadditionssalter dessa innehaollande laekemedel och deras framstaellningsfoerfarande
IE802690L (en) Substituted 2-phenylamino-imidazolines-(2)
SE7901316L (sv) Derivat av dehydrocykliciminsyror
ES458810A1 (es) Procedimiento para la preparacion de nuevos 2-(4-fenil-4- cianobutil)-1,2,3,4-tetrahidro-5(h)pirido(4,3-b)-indoles.
GB2001963A (en) Esters of mercaptopropanoic acids

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 7703223-3

Format of ref document f/p: F