SE1351433A1 - Copper-containing wound healing material - Google Patents
Copper-containing wound healing materialInfo
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- SE1351433A1 SE1351433A1 SE1351433A SE1351433A SE1351433A1 SE 1351433 A1 SE1351433 A1 SE 1351433A1 SE 1351433 A SE1351433 A SE 1351433A SE 1351433 A SE1351433 A SE 1351433A SE 1351433 A1 SE1351433 A1 SE 1351433A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
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- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Artificial Filaments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sårläkningsmaterial innefattande sårförband vilka innefattar material såsom textil, polymerfiber, polymerfilm, syntetfiber, cellulosafiber, ullfiber eller bomullsfiber, varvid sårläkningsmaterialet innefattar väsentligen rent koppar.Wound healing materials comprising wound dressings which comprise materials such as textile, polymer fiber, polymer film, synthetic fiber, cellulose fiber, wool fiber or cotton fiber, the wound healing material comprising substantially pure copper.
Description
AWAPATENT AB Kontor/HandlaggareAnsokningsnrVar. referens Linkoping/Sofia Willquist/SZJ11016009 1 KOPPARINNEHALLANDE SARLAKNINGSMATERIAL Tekniskt omrade Foreliggande uppfinning hanfor sig till ett sarlakningsmaterial innefattande kopparpulverhaltiga material, eller koppartradsinnehallande material. Uppfinningen hanfor sig vidare till anvandningen av dessa material for behandling av sar, brannskador och andra hudakommor. AWAPATENT AB Office / Administrator Application No. Where. reference Linkoping / Sofia Willquist / SZJ11016009 1 COPPER CONTAINING SCARFING MATERIAL Technical area The present invention relates to a slacking material comprising copper powder-containing materials, or containing copper wire material. The invention further relates to the use of these materials for the treatment of wounds, burns and other skin lesions.
Bakqrund !nom omradet f6r sarbehandling star man idag inf6r ett globalt problem med okad antibiotikaresistens, som inte bara forsvarar sarlakning, utan aven är potentiellt dodligt for personer med svarartade sar, t ex fran brannskador etc. Det är onskvart att hitta behandlingar som inte innefattar anvandandet av antibiotika. En farsk undersokning inom omradet for antiseptiska forband, dvs. fOrband som kan appliceras lokalt pa huden och fOrhindra forOkning av eller dodar mikroorganismer, av Lindholm (Antiseptiska preparat vid sarbehandling) ger en genomgang av de antiseptiska fOrband som idag anvands inom sjukvarden. Lindholm raknar upp ett flertal olika alternativ till antibiotika sasom nnedicinsk honung, jod, PHMB, hydrofoba fOrband som verkar genom att attrahera bakterier till f6rbandet och silver. Background In the area of special treatment, we are today facing a global problem increased antibiotic resistance, which not only defends scarring, but is also potentially fatal to people with blackheads, for example from burns, etc. It is unfortunate to find treatments that do not involve the use of antibiotics. A recent study in the field of antiseptic dressings, ie. Bandages that can be applied topically to the skin and prevent proliferation of or kills microorganisms, by Lindholm (Antiseptic preparations in wound treatment) gives an overview of the antiseptic dressings that are currently used in healthcare. Lindholm lists a number of different alternatives to antibiotics, such as medicinal honey, iodine, PHMB, hydrophobic dressings that work by attracting bacteria to the dressing and silver.
Ett problem med silver är dock lackage av silverjoner till t ex vattendrag, vilket inte är onskvart ur miljosynpunkt. A problem with silver, however, is the lacquering of silver ions to, for example, watercourses, which is not unfortunate from an environmental point of view.
Som ett alternativ beskrivs i Borkow (Copper Oxide...) anvandningen av kopparoxid i olika typer av forband, samt EP1809306, vilket aven detta dokument beskriver anvandningen av kopparoxid for olika typer av sarforband. As an alternative, Borkow (Copper Oxide ...) describes the use of copper oxide in different types of joints, and EP1809306, which also this document describes the use of copper oxide for different types of sarforband.
Sammanfattninq Ett syfte med foreliggande uppfinning är darfor att astadkomma ett forbattrat sarlakningsmaterial for t ex brannskador eller infekterade sar samt 30 anvandningen av detta sarlakningsmaterial vid olika applikationer. 2 Detta syfte astadkonns enligt en forsta aspekt av ett sarlakningsmaterial innefattande sarforband vilka innefattar material sasom polymerfiber, polymerfilm, syntetfiber, cellulosafiber, ullfiber eller bomullsfiber, varvid sarlakningsnnaterialet innefattar vasentligen rent koppar. Summary An object of the present invention is therefore to provide an improved slackening material for eg burns or infected wounds and the use of this slackening material in various applications. 2 This object is achieved according to a first aspect of a lacquer material comprising sarp dressings which comprise materials such as polymer fiber, polymer film, synthetic fiber, cellulose fiber, wool fiber or cotton fiber, the lacquer material comprising substantially pure copper.
Genom att huden har ett pH varde <7, vid vilket kopparjoner falls ut kommer kopparjoner att frisattas vid kontakt med hud, och avdodar harmed bakterier och virus. Koppar tas dock inte upp av kroppen och avger inte nagra joner vid pH over 7. Da huden har ett pH pa 4,5 — 5 sa avges kopparjonerna endast i kontakt med huden och far en lokalverkan. Eventuella kvarliggande joner pa kroppen skoljs bort i samband med tvatt. Nar kopparpulver kommer i kontakt med sur fuktig miljo frigors kopparjoner. Hur mycket joner som frigors beror pa pH och pa den yta som fuktexponeras. Ett fin malt pulver avger mer joner jamfort med ett grovt pulver. Mansklig hud har enligt litteratur normalt pH lagre an pH 6 vilket innebar att kopparjoner frigOrs vid kontakt med huden om huden är fuktig. Manniskan är mindre kanslig for intag av koppar eftersom kroppen reglerar upptaget i levern. Antic& Mgt kopparintag genom fodan irriterar mag- och tarmkanalen. Aven damm kan ursaka olagenhet. Nagra rapporterade effekter pa grund av kopparupptag genom huden har jag inte funnit. Bakterier och mikroorganismer är sarskilt kansliga for paverkan av kopparjoner. Kopparpulver klassas darfor som mycket giftiga for vattenlevande organismer. Avfall av kopparpulver i flagon form ska hanteras som farligt avfall. Because the skin has a pH value <7, at which copper ions precipitate copper ions will be released on skin contact, killing bacteria and viruses. However, copper is not absorbed by the body and does not emit any ions at pH above 7. As the skin has a pH of 4.5 - 5, the copper ions are only released in contact with the skin and have a local effect. Any remaining ions on the body are washed away in connection with washing. When copper powder comes in contact with acidic moist environment, copper ions are released. How much ions are released depends on the pH and the surface exposed to moisture. A fine ground powder emits more ions compared to a coarse powder. According to the literature, human skin normally has a pH lower than pH 6, which meant that copper ions were released upon contact with the skin. if the skin is moist. Man is less susceptible to copper intake because the body regulates uptake into the liver. Antic & Mgt copper intake through the food irritates the gastrointestinal tract. Dust can also cause malaise. I have not found any reported effects due to copper uptake through the skin. Bacteria and microorganisms are particularly susceptible to the effects of copper ions. Copper powder is therefore classified as highly toxic to aquatic organisms. Waste of copper powder in flake form must be treated as hazardous waste.
Genom att applicera koppar tillsammans med olika material kan detta anvandas kontrollerat i samman hang cla det är motiverat och i den utstrackning som är nodvandigt. By applying copper together with different materials, this can be used in a controlled context where it is justified and in it extent that is necessary.
Denna produkt kan ocksa i manga fall ersatta eller minska anvandandet av antibiotika. This product can also in many cases replace or reduce the use of antibiotics.
Med "vasentligen rent" koppar menas att sarlakningsmaterialet innefattar koppar (29Cu) i flagon form och inte koppar i jonform sasom kopparoxid etc.. Kopparoxid som är en oxiderad form av koppar slapper ocksa lattare ifran sig kopparjoner, med risk for att kopparjoner aven avges inte bara lokalt dar behandlingen behovs, vilket medfor en okad risk for negativ miljOpaverkan. 3 Genonn att anvanda rent koppar i olika former och inkorporera i olika material for att specifikt anvandas da behov foreligger att ta hand om t ex infekterade sar for att laka dessa sannt forebygga spridning av dessa. Detta kan aven anvandas i samband med operationer och saromlaggningar da risk foreligger vid spridning av svarbemastrade infektioner t ex i form av multiresistenta bakterier sannt pa infektionsavdelningar dar patienter vardas med olika grader av infektioner. By "substantially pure" copper is meant that the leaching material comprises copper (29Cu) in flake form and not copper in ionic form as copper oxide etc .. Copper oxide which is an oxidized form of copper also releases copper ions more easily, with the risk that copper ions are also emitted not only locally where the treatment is needed, which entails an increased risk of negative environmental impact. 3 By using pure copper in different forms and incorporating it into different materials to be used specifically when there is a need to take care of, for example, infected wounds in order to leach them, they truly prevent their spread. This can also be used in connection with operations and reorganizations at risk is present in the spread of response-mastered infections, for example in the form of multi-resistant bacteria, true in infection wards where patients are treated with different degrees of infections.
Enligt en utforingsform kan namnda koppar forekomma som kopparpulver, varvid kopparpulvret är inbaddat i fibern pa sa satt att det 10 atminstone delvis exponeras vid namnda fibers yta. According to one embodiment, said copper may be present as copper powder, the copper powder being embedded in the fiber in such a way that it is at least partially exposed at the surface of said fiber.
Med att kopparpulvret atminstone delvis exponeras pa ytan menas att kopparpulvret kan vad inbaddat i fibern t ex genom olika tillverkningsprocesser eller vara blandad med fibern pa sa satt att pulvret har fOrmagan att komma i kontakt med den hudyta som sarlakningsmaterialet har for avsikt att tacka. By the copper powder being at least partially exposed on the surface is meant that the copper powder can be embedded in the fiber, for example through various manufacturing processes or be mixed with the fiber in such a way that the powder has the ability to come into contact with the skin surface of the coating material. for intention to thank.
Enligt en annan utfOringsform kan namnda koppar forekomma som koppartrad, vilken tad är vavd eller spunnen in i sarlakningsmaterialet. According to another embodiment, said copper can occur as a copper wire, which is wound or spun into the leaching material.
Genom att vava eller spinna in koppartrad tillsammans med materialet som utgor sarlakningsmaterialet kan man pa ett enkelt satt inkorporera kopparn i materialet och det kommer ocksa all var exponerat for den hudyta som avses behandlas genom sarlakningsmaterialet. By weaving or spinning copper wire together with the material that makes up the leaching material, one can easily incorporate the copper in the material and it will also all be exposed to the skin surface intended to be treated by the sarlaking material.
Enligt en alternativ utforingsform innefattar materialet bade kopparpulver och koppartrad. According to an alternative embodiment, the material comprises both copper powder and copper wire.
Enligt en utforingsform av den forsta aspekten av uppfinningen kan 25 kopparpulvret vara fastlimmat pa materialet och pa sa satt direkt anbringas mot hud vid anvandning darav. According to an embodiment of the first aspect of the invention, the copper powder may be glued to the material and thus applied directly to the skin in use.
Enligt en andra aspekt tillhandahalls anvandning av ett sarlakningsmaterial enligt nagot av foregaende krav, f6r behandling av sar och vavnadsskador innefattade brannskador, infekterade sar. According to a second aspect, there is provided the use of a wound dressing material according to any one of the preceding claims, for the treatment of wounds and tissue injuries including burns, infected wounds.
Sarlakningsmaterialet kan aven anvandas for att behandla andra hudakomnnor. The dressing material can also be used to treat others hudakomnnor.
Genom att sarlakningsmaterialet innefattar koppar kan en effektiv lokal avdOdning eller begransning av bakterier som orsakar infektioner i sar 4 astadkonnnnas, vilket gynnar sarlakningsprocesser och f6rhindrar att livshotande tillstand sasom sepsis uppstar. Because the leaching material comprises copper, an effective local killing or control of bacteria that cause infections in wounds can 4 astadkonnnnas, which favors slackening processes and prevents life-threatening conditions such as sepsis from occurring.
Enligt en utf6ringsform av den andra aspekten kan materialet vara ett forband som innefattar fibrer som innefattar kopparpulver eller koppartrad. According to an embodiment of the second aspect, the material may be a dressing comprising fibers comprising copper powder or copper wire.
Enligt ytterligare en utforingsform kan namnda material vara utformat av ett gasvavsmaterial som innefattar kopparpulver eller koppartrad. According to a further embodiment, said material can be designed of a gauze material comprising copper powder or copper wire.
Enligt en alternativ utf6ringsform kan materialet vara utformat av stickad bomullstub som innefattar kopparpulver eller koppartrad. According to an alternative embodiment, the material may be formed of knitted cotton stub which comprises copper powder or copper wire.
Materialet kan vara utformat av ull eller merinoull som innefattar 10 kopparpulver eller koppartrad. The material may be formed of wool or merino wool comprising copper powder or copper wire.
Enligt en utf6ringsform av den andra aspekten kan materialet som anvands vara en textil med fibrer som innehaller kopparpulver eller koppartrad, for att bringas i kontakt med mindre eller storre delar av kroppsyta som är angripen av infektion. According to an embodiment of the second aspect, the material used may be a textile with fibers containing copper powder or copper wire, to be brought into contact with smaller or larger parts of body surface which are infested with infection.
Enligt ytterligare en utfOringsform kan materialet som anvands vara ett sjalvhaftande syntetiskt material med inbaddat kopparpulver eller koppartrad, vilket material vid anbringande kommer i kontakt med huden. According to a further embodiment, the material used may be one self-adhesive synthetic material with embedded copper powder or copper wire, which material comes into contact with the skin during application.
Materialet som innefattar kopparpulver eller koppartrad, och som anvands enligt den andra aspekten kan vara, enligt en utforingsform, nagot av bomull, merinoull, syntetfiber for: underbyxor, bysthallare, annningsinlagg, strumpor, forband till amputerade, troja. The material comprising copper powder or copper wire, and used according to the second aspect may be, according to one embodiment, somewhat of cotton, merino wool, synthetic fiber for: underpants, bras, other inserts, socks, bandages for amputees, trojas.
Genonn att anvanda material som innefattar kopparpulver eller koppartrad it ex ett amningsinlagg kan man behandla sarbildning i samband med amning, eller sa kan sarlakningsmaterialet inga i, utg6ra del av eller besta av t ex underbyxor vilka enkelt kan anbringas en patient i behov av sarlakande insatser. By using materials that include copper powder or copper wire in, for example, a breastfeeding insert, wound formation can be treated in connection with with breastfeeding, or so the slacking material can not in, form part of or consist of, for example, underpants which can easily be fitted to a patient in need of similar interventions.
Materialet som anvands kan vara en sarlakningstextil, extruderad sarlakningsfilm, filament eller holje som innehaller kopparpulver eller koppartrad. The material used may be a lacquer textile, extruded lacquer film, filament or casing containing copper powder or copper wire.
Enligt en alternativ utf6ringsform kan sarlakningsmaterialet som anvands vara ett kladesplagg och eller ett sanglinne. According to an alternative embodiment, the coating material can be used as used to be a clothing item and or a song linen.
Pa sa satt kan man inkorporera koppar i t ex patientplagg och sanglinnen fOr anvandning pa sjukhus och andra vardanlaggningar. In this way, copper can be incorporated into, for example, patient clothing and song linens for use in hospitals and other care facilities.
Darigenonn kan man fa en aktiv sarlakning utan att applicera tatslutande forband. Darigenonn you can get an active sarlakning without applying tight-fitting dressings.
Enligt denna alternativa utforingsform kan sarlakningsmaterialet helt eller delvis innehaller koppar i form av kopparpulver eller koppartradar. According to this alternative embodiment, the coating material may wholly or partly contain copper in the form of copper powder or copper radar.
Materialet kan t ex utformas pa sa satt att det endast är forsett med kopparpulver eller koppartrad pa en begransad yta darav, t ex i en arm eller pa en ryggdel, beroende av vart patienten har sar som ska behandlas medelst sarlakningsmaterialet innefattande kopparpulver eller koppartrad. The material can, for example, be designed in such a way that it is only provided with copper powder or copper wire on a limited surface thereof, for example in an arm or on a back part, depending on where the patient has wounds to be treated by means of the leaching material comprising copper powder or copper wire.
Kort beskrivninq av ritninqar Uppfinningen kommer i fortsattningen att beskrivas ytterligare genom ett utforingsexempel med hanvisning till bifogade ritningar. Brief description of the drawings The invention will be further described in the following by means of an exemplary embodiment with reference to the accompanying drawings.
Fig. 1 är ett fotografi av en odlingsplatta palagda koppartradar. Fig. 1 is a photograph of a culture plate coated with copper radar.
Fig. 2 är ett fotografi av odlingsplattan i Fig. 1 dar koppartradarna avlagsnats. Fig. 3 är ett fotografi av tva odlingsplattor med palagt kopparinnehallande tyg. Fig. 4 är ett fotografi av odlingsplattorna i Fig.3 dar tyget avlagsnats. Fig. 2 is a photograph of the cultivation plate in Fig. 1 where the copper wires have been deposited. Fig. 3 is a photograph of two culture plates with padded copper-containing fabric. Fig. 4 is a photograph of the culture plates in Fig. 3 where the fabric has been removed.
Fig. 5 är ett fotografi av ett tatstickat koppartyg. Fig. 5 is a photograph of a tat-knitted copper cloth.
Detaljerad beskrivninq Enligt uppfinningen innefattar sarlakningsmaterial en mangd olika typer av sarforband utfornnade av material sasonn textil, polynnerfiber, polynnerfilnn, syntetfiber, cellulosafiber, ullfiber eller bomullsfiber. Detailed description According to the invention, lacquering materials comprise a variety of different types of lacquers formed from materials such as textile, polyner fiber, polyner film, synthetic fiber, cellulose fiber, wool fiber or cotton fiber.
Dessa sarforband är avsedda att anbringas pa hudytor som omfattas 25 av olika typer av sar, sarbildning, brannskador eller andra typer av hudakommor, t ex psoriasis, blasor, koppor etc. i syfte att bidra till lakningen av dessa sar och akommor. These wound dressings are intended to be applied to skin surfaces covered by various types of wounds, ulceration, burns or other types of skin grains, such as psoriasis, blisters, smallpox, etc. in order to contribute to the healing of these wounds and scars.
Sarlakningsmaterialet innefattar rent koppar29Cu i olika former eftersom uppfinning bygger pa en upptackt att rent koppar som infors i olika typer av sarlakningsmaterial har en antibakteriell och antiseptisk verkan mot en mangd olika mikroorganismer. Genom att inkludera eller inkorporera rent koppar i sarlakningmaterialet fas en lokal verkan av kopparjoner som dodar 6 eller begransar nnikroorganisnnernas utbredning och damned paverkar sarlakningen positivt. The leaching material comprises pure copper 29Cu in various forms since the invention is based on a discovery that pure copper which is introduced into various types of leaching material have an antibacterial and antiseptic effect against a variety of microorganisms. By including or incorporating pure copper into the leaching material, a local effect of copper ions killing 6 or limits the spread of the nikroorganisms and damned affects the leaching positively.
Enligt en utforingsform sa innefattar sarlakningsmaterialet koppar i pulverform. According to one embodiment, the leaching material comprises copper in powder form.
Kopparpulvret kan t ex vara av typen som tillverkas av Thermo Scie ATG BID GC, med CAS-nummer 7440-50-8, men aven andra typer av kopparpulver är nnojliga att anvanda. The copper powder can, for example, be of the type manufactured by Thermo Scie ATG BID GC, with CAS number 7440-50-8, but other types of copper powder are also suitable for use.
Nar kopparpulver kommer i kontakt med sur fuktig miljo frigors kopparjoner. Hur mycket joner som frig6rs beror pa pH och pa den yta som fuktexponeras. Ett finmalt pulver avger mer joner jamfort med ett grovt pulver. Mansklig hud har enligt litteratur normalt pH lagre an pH 6 vilket innebar att kopparjoner frigOrs vid kontakt med huden om huden är fuktig. Manniskan är mindre kanslig for intag av koppar eftersom kroppen reglerar upptaget i levem, dock finns det inte rapporterade effekter pa grund av kopparupptag genom huden. Bakterier och mikroorganismer är sarskilt kansliga fOr paverkan av kopparjoner, darfor är det viktigt att avgransa exponeringen av koppar till just det omrade av huden som är i behov av det och undvika att koppar och kopparjoner lacker ut i den omgivande miljOn. When copper powder comes in contact with acidic moist environment, copper ions are released. How much ions are released depends on the pH and on the surface moisture exposed. A finely ground powder emits more ions compared to a coarse powder. According to the literature, human skin normally has a pH lower than pH 6, which meant that copper ions are released on contact with the skin if the skin is moist. Humans are less likely to ingest copper because the body regulates uptake into the liver, however, there are no reported effects due to copper uptake through the skin. Bacteria and microorganisms are particularly susceptible to the effects of copper ions, which is why it is important to delimit the exposure of copper to the exact area of the skin that is in need of it and to avoid copper and copper ions leaching into the surrounding environment.
Kopparpulvret kan anbringas de angivna materialen pa olika satt. The copper powder can be applied to the specified materials in different ways.
Kopparpulvret bor dock anbringas pa sa satt att pulvret pa nagot satt projiceras ut ifran ytan av sarlakningsmaterialet for att kunna komma i kontakt med hudytan som det är avsett att behandla. However, the copper powder should be applied in such a way that the powder is in some way projected out of the surface of the coating material in order to be able to come into contact with the skin surface which it is intended to treat.
Enligt en utforingsform kan detta ske i samband med fargning dar kopparpulver blandas i fargen. According to one embodiment, this can take place in connection with dyeing where copper powder is mixed into the dye.
Enligt en alternativ utforingsform kan pulvret bestros pa en klisteryta, da klister lagts pa befintlig textil. According to an alternative embodiment, the powder can be sprayed on an adhesive surface. when glue is laid on existing textile.
Vidare, enligt ytterligare en utforingsform kan kopparpulver bearbetas in i materialet genom tryck och varme. Furthermore, according to a further embodiment, copper powder can be processed into the material by pressure and heat.
Kopparpulver kan aven enligt en alternativ utforingsform bearbetas in i 30 textilfibern i samband med att flera tradar spinns tillsammans. Copper powder can also, according to an alternative embodiment, be processed into the textile fiber in connection with several threads being spun together.
Enligt en utforingsform är forbandsmaterialet är en nonwowen-vav av syntetisk fiber varvid kopparpulver är inbaddat dari varvid en del namnda partiklar är exponerade och utskjutande ur dess ytor. 7 Enligt en alternativ utforingsforrn sa innefattar sarlakningsmaterialet tradar av koppar som inkorporerats i materialet antingen genom samextrudering av fiber eller genom att spinnas, stickas eller vavas in i materialet. Man kan saledes vava in, sticka in eller spinna ihop koppartraden med en textil. According to one embodiment, the dressing material is a nonwoven fabric synthetic fiber wherein copper powder is embedded therein wherein some said particles are exposed and protruding from its surfaces. 7 According to an alternative embodiment, the leaching material comprises threads of copper incorporated into the material either by co-extrusion of fiber or by spinning, knitting or weaving into the material. You can thus wade in, knit in or spin the copper wire together with a textile.
Sarlakningsmaterialet kan besta av ett material dar koppartradarna stickats eller vavts samman pa sa satt att materialet endast bestar av koppartradar. Enligt en alternativ utforingsform vavs, stickas eller spinns koppartradarna samman med ett textilmaterial eller textiltradar eller flagon annan typ av fiber sa att sarlakningsmaterialet bestar av en kombination av koppartradar och tradar av nagot annat material. The coating material may consist of a material in which the copper wires are knitted or woven together in such a way that the material consists only of copper wires. According to an alternative embodiment, the copper wires are woven, knitted or spun together with a textile material or textile wires or flakes. another type of fiber said that the sarlaking material consists of a combination of copper threads and threads of some other material.
Materialet kan besta av koppartradar som anordnats pa sa satt att de ligger dikt an mot varandra, vilket illustreras av figur 5. The material may consist of copper radars arranged in such a way that they are close to each other, as illustrated by Figure 5.
Tradarna kan ha dimensionerna med diameter i ett intervall Than 0,005 15 till 0,20 mm. Enligt en utforingsform ar diametern 0,15 mm, enligt en alternativ utfOringsform är den 0,10 mm, och enligt ytterligare en utfOringsform 0,0 MM. The trades can have the dimensions with diameter in a range Than 0.005 15 to 0.20 mm. According to one embodiment, the diameter is 0.15 mm, according to an alternative embodiment is 0.10 mm, and according to another embodiment 0.0 MM.
Enligt ytterligare en utbringsform sa innefatta materialet en kombination av kopparpulver och koppartrad. According to a further form of application, the material comprises a combination of copper powder and copper wire.
Sarlakningsmaterial kan ocksa besta av operationstextilier i form av syntetfiber eller bomullstextil eller merinoull, varvid kopparpulver och/eller koppartrad ingar, for anvandning i sannband med operation och onnlaggningar av sar da risk foreligger eller vid dokumenterad smittorisk. Slack lacing materials can also consist of surgical textiles in the form of synthetic fibers or cotton textiles or merino wool, whereby copper powder and / or copper threads, for use in true bands with surgery and disposal of special risk or in case of documented risk of infection.
Vidare kan sarlakningsmaterialet besta av, utgora del av eller innefatta olika typer av textilier, vilka har forsetts med kopparpulver och/eller koppartrad. Dessa textilier kan vara i form av klader, skyddsklader, operationsklader for personal i sannband med omhandertagande av patienter med befarad eller dokumenterad bakteriesmitta. Furthermore, the leaching material may consist of, form part of or include various types of textiles, which have been fortified with copper powder and / or copper wire. These textiles can be in the form of clothes, protective clothes, surgical clothes for staff in true straps with care of patients with feared or documented bacterial infection.
Exempel Forsok har utforts med rent koppar i olika former for att sakerstalla den antibakteriella och antiseptiska verkan av kopparen. Example Experiments have been carried out with pure copper in various forms to secure it antibacterial and antiseptic effect of copper.
Tygproverna placerades pa utodlade bakterielosningar (pa blodagarplattor och inkuberades i varmeskap i ca 16 h 36-37 grader. 8 I forsok ett odlades S aureus pa blodagar vilket inkuberades i ca 16 h vid 36-37°C. Som visas i Fig. 1 lades darpa koppartradar med dimensionen 0,10 mm i diameter pa odlingsplattorna och dessa inkuberades i varmeskap. Efter en tid togs koppartraden bort och man kunde klart notera att en avdodning av mikroorganisnnerna skett, vilket ocksa visas i Fig. 2. The fabric samples were placed on cultured bacterial solutions (on blood agar plates and incubated in a refrigerator for about 16 hours at 36-37 degrees. 8 In Experiment One, S aureus was grown on blood agar which was incubated for about 16 hours at 36-37 ° C. As shown in Fig. 1, copper copper wires with the dimension 0.10 mm in diameter were placed on the culture plates and these were incubated in heating cabinets. After a while, the copper line was removed and it was clear that one killing of the microorganisms has taken place, which is also shown in Fig. 2.
I ett andra forsok odlades S aureus pa blodagar. Som visas i Fig. 3 lades darpa en textil innefattande koppartradar med dimensionen 0,10 mm pa odlingsplattorna och dessa inkuberades i varmeskap. Efter en tid togs textilen bort och man kunde klart notera att en avdodning av mikroorganismerna skett, vilket ocksa visas i Fig. 4. In a second experiment, S aureus was grown on blood days. As shown in Fig. 3, a textile comprising copper radar with the dimension 0.10 mm was placed on the culture plates and these were incubated in a heating cabinet. After a while, the textile was removed and it could be clearly noted that a killing of the microorganisms happened, which is also shown in Fig. 4.
Forsok har aven gjorts med det koppartyg som visas i Fig. 5 samt kopparpulver som klistrats fast pa ett sarlakningsfOrband. Aven vid dessa f6rs6k odlades S aureus och efter inkubation med palagt koppartyg respektive "kopparpulvertejp" noterades tydligt att avdOdning av bakterier 15 skett. Attempts have also been made with the copper fabric shown in Fig. 5 as well copper powder glued to a lacquer dressing. Also in these experiments S aureus was grown and after incubation with coated copper cloth respectively "copper powder tape" was clearly noted that killing bacteria took place.
Fran dessa forsok är det klart att koppar har en avdodande och begransande effekt, aven dá koppar är inkorporerat i ett textilmaterial. From these experiments it is clear that copper has a killing and limiting effect, even though copper is incorporated into a textile material.
Claims (2)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1351433A SE1351433A1 (en) | 2013-12-02 | 2013-12-02 | Copper-containing wound healing material |
| PCT/SE2014/051361 WO2015084231A1 (en) | 2013-12-02 | 2014-11-17 | Wound healing material comprising copper |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1351433A SE1351433A1 (en) | 2013-12-02 | 2013-12-02 | Copper-containing wound healing material |
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| SE1351433A1 true SE1351433A1 (en) | 2015-06-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE1351433A SE1351433A1 (en) | 2013-12-02 | 2013-12-02 | Copper-containing wound healing material |
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| SE (1) | SE1351433A1 (en) |
| WO (1) | WO2015084231A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016210045A1 (en) * | 2015-06-25 | 2016-12-29 | Medicore Global Llc | Wound dressing comprising copper |
| CA3128905A1 (en) * | 2019-02-27 | 2020-09-03 | Lucas Hector Izard SMITH | Breathable adhesive bandages |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5238013A (en) * | 1975-09-20 | 1977-03-24 | Hitachi Cable Ltd | Sanitary treatment of materials used in contact with the skin |
| GB2092006A (en) * | 1981-02-04 | 1982-08-11 | Landstingens Inkopscentral | Germicidal dressing |
| GB9320407D0 (en) * | 1993-10-04 | 1993-11-24 | Large Allan V | Rheum-ease transdermal copper patch |
| US6171606B1 (en) * | 1999-12-06 | 2001-01-09 | Robert Lyons | Flexible therapeutic copper patch and brace |
| KR20140013078A (en) * | 2004-11-07 | 2014-02-04 | 쿠프론 인코포레이티드 | Copper containing materials for treating wounds, burns and other skin conditions |
| EP1904297B1 (en) * | 2005-06-03 | 2017-01-04 | Prezacor, Inc. | Compositions comprising elemental metals and uses therefor |
| GB201011801D0 (en) * | 2010-07-14 | 2010-08-25 | Luxion Holdings Ltd | Anti-microbial products |
| FI123878B (en) * | 2011-01-19 | 2013-11-29 | Silvergreen Oy Ltd | An antimicrobial wound dressing and method for its preparation |
| BR112014020692A2 (en) * | 2012-02-17 | 2019-09-24 | Riesinger Birgit | liquid-permeable primary dressing or plaster, wound care device and use of a primary plaster dressing |
| US20130226061A1 (en) * | 2012-02-29 | 2013-08-29 | Richard M. Dickson | Multi-layer bandages and methods for dressing a wound |
-
2013
- 2013-12-02 SE SE1351433A patent/SE1351433A1/en not_active Application Discontinuation
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- 2014-11-17 WO PCT/SE2014/051361 patent/WO2015084231A1/en active Application Filing
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